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https://www.readbyqxmd.com/read/29648652/arabidopsis-aspartic-protease-aspg1-affects-seed-dormancy-seed-longevity-and-seed-germination
#1
Wenzhong Shen, Xuan Yao, Tiantian Ye, Sheng Ma, Xiong Liu, Xiaoming Yin, Yan Wu
Seed storage proteins (SSPs) provide free amino acids and energy for the process of seed germination. Although degradation of SSPs by the aspartic proteases (APs) isolated from seeds have been documented in vitro, there is still no genetic evidence for involvement of APs in seed germination. Here we report that the aspartic protease ASPG1 (ASPARTIC PROTEASE IN GUARD CELL 1) plays an important role in the process of dormancy, viability and germination of Arabidopsis seeds. We show that aspg1-1 mutants have enhanced seed dormancy and reduced seed viability...
April 10, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29624847/use-of-direct-oral-anticoagulants-in-antiphospholipid-syndrome
#2
REVIEW
Hannah Cohen, Maria Efthymiou, David Isenberg
The direct oral anticoagulants (DOACs) are therapeutic alternatives to warfarin and other vitamin K antagonists (VKAs), and the standard of care for many indications. VKAs are conventional therapy for the treatment and secondary thromboprophylaxis of thrombotic antiphospholipid syndrome (APS), but are often problematic due to the variable sensitivity of thromboplastins to lupus anticoagulant. Thus, the International Normalised Ratio may not accurately reflect anticoagulation intensity, or be clinically effective...
April 6, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29620217/effect-and-mechanism-of-the-a%C3%AE-2%C3%A2-gp-i-rh%C3%AE-2%C3%A2-gp-i-complex-on-jeg%C3%A2-3-cell-proliferation-migration-and-invasion
#3
Xiumin Lu, Lei Ren, Wenjing Zhang, Yanhong Liu
Antiphospholipid antibody (aPL)‑mediated antiphospholipid syndrome (APS) is an autoimmune disease. Upon binding to aPL, the primary antigen of aPL, β2‑glycoprotein I (β2‑GP I), induces abnormal immune function, which further activates downstream signaling pathways in the cell and eventually leads to APS. The present study aimed to determine whether β2‑GP I antigen and anti‑β2‑glycoprotein I antibody (aβ2‑GP I), which belong to the aPL class of antibodies, may affect human chorionic epithelium cell (JEG‑3) proliferation, migration and invasion...
March 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29608758/neutrophil-extracellular-trap-release-is-associated-with-antinuclear-antibodies-in-systemic-lupus-erythematosus-and-anti-phospholipid-syndrome
#4
Maarten van der Linden, Lucas L van den Hoogen, Geertje H A Westerlaken, Ruth D E Fritsch-Stork, Joël A G van Roon, Timothy R D J Radstake, Linde Meyaard
Objectives: Increased release of neutrophil extracellular traps (NETs) is implicated in the activation of plasmacytoid dendritic cells, vascular disease and thrombosis in SLE and APS. However, studies comparing NET release between patients with SLE and APS are lacking. Here we evaluated plasma-induced NET release in a large cohort of patients with SLE, SLE + APS and primary APS in relation to clinical and serological parameters. Methods: Neutrophils from healthy controls were exposed to plasma of heterologous healthy controls (n = 27) or SLE (n = 55), SLE + APS (n = 38) or primary APS (PAPS) (n = 28) patients and NET release was quantified by immunofluorescence...
March 28, 2018: Rheumatology
https://www.readbyqxmd.com/read/29607431/evaluation-of-patients-with-gastric-polyps
#5
Sehmus Olmez, Suleyman Sayar, Bunyamin Saritas, Ayla Yildiz Savas, Ufuk Avcioglu, Ilyas Tenlik, Ersan Ozaslan, Hasan Tankut Koseoglu, Emin Altiparmak
OBJECTIVE: The incidence of gastric polyps (GPs) greatly differs according to study populations and was found to be 0.33%-6.7% in various studies. The majority of GPs are composed of hyperplastic polyps (HPs), fundic gland polyps (FGPs), and adenomatous polyps (APs). Although APs have a high risk of malignant potential, sporadic FGPs have no malignant potential. Conversely, HPs have a low risk of malignant potential. It is not sufficient to perform a biopsy to identify the polyp type and the presence of dysplasia; thus, some polyps may require multiple biopsies or total excision...
2018: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/29602862/safety-and-efficacy-of-mechanical-thrombectomy-in-acute-ischemic-stroke-of-anticoagulated-patients
#6
Vincent L'Allinec, Marielle Ernst, Mathieu Sevin-Allouet, Nathalie Testard, Béatrice Delasalle-Guyomarch, Benoit Guillon, Mikael Mazighi, Hubert Desal, Romain Bourcier
BACKGROUND: Anticoagulated patients (APs) are currently excluded from acute ischemic stroke reperfusion therapy with intravenous recombinant tissue plasminogen activator (IV-rtPA); however, these patients could benefit from mechanical thrombectomy (MT). Evidence for MT in this condition remains scarce. The aim of this study was to analyze the safety and efficacy of MT in APs. METHODS: We analyzed three patient groups from two prospective registries: APs with MT (AP-MT group), non-anticoagulated patients treated with MT (NAP-MT group), and non-anticoagulated patients treated with IV-rtPA and MT (NAP-IVTMT group)...
March 30, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29588359/antiphospholipid-syndrome-presenting-as-acute-mesenteric-venous-thrombosis-involving-a-variant-inferior-mesenteric-vein-and-successful-treatment-with-rivaroxaban
#7
Kevin Singh, Gulam Khan
Acute mesenteric venous thrombosis (MVT) is the rarest cause of acute mesenteric ischaemia, so thrombosis of a variant inferior mesenteric vein (IMV) is especially uncommon in the setting of antiphospholipid syndrome (APS). Here, we present such a case of seronegative APS initially manifesting as an anomalous IMV thrombosis in a 76-year-old woman. Although guidelines support anticoagulation with vitamin K antagonists in these patients, we anticoagulated with rivaroxaban (a direct oral anticoagulant (DOAC)) due to patient preference, which resulted in complete clinical and endoscopic resolution...
March 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29563327/inhibition-of-the-%C3%AE-subunit-of-phosphoinositide-3-kinase-pi3k-in-heart-increases-late-sodium-current-and-is-arrhythmogenic
#8
Tao Yang, David F Meoli, Javid Moslehi, Dan M Roden
While inhibition of phosphoinositide 3-kinase (PI3K) is an emerging strategy in cancer therapy, we and others have reported that this action can also contribute to drug-induced Q-T prolongation and arrhythmias by increasing cardiac late sodium current (INaL). Previous studies in mice implicate the PI3K-α isoform as the major effector of the INaL action. Here, we have determined the effects of new anticancer drugs targeting specific PI3K isoforms on INaL and action potentials (APs) in mouse cardiomyocytes and CHO cells...
March 21, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29558350/-systemic-lupus-erythematosus-and-antiphospholipid-syndrome-diagnostic-and-therapeutic-problems
#9
Zbigniew Zdrojewski
Recognizing the antiphospholipid syndrome (APS) in patients with lupus (SLE) can be difficult and therefore underestimated. Detection of antiphospholipid antibodies (aPL) in each patient with SLE should be done as a rule. Introduction of the new classification criteria of this syndrome will certainly improve the recognition of APS in the future. The Sapporo APS classification criteria (1998) were replaced by the Sydney criteria in 2006. Based on the most recent criteria, classification with APS requires one clinical and one laboratory manifestation...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29550831/a-polysaccharide-from-amusium-pleuronectes-combined-with-praziquantel-treatment-ameliorates-hepatic-fibrosis-in-schistosoma-japonicum-infected-mice
#10
Xiaoniu Tang, Wei Hu, Yechao Lv, Wenqi Zhang, Tian Sun, Yuxin Jiang, Xiaodong Zhan, Shulin Zhou
BACKGROUND Polysaccharides from bivalves have multiple bioactivities in various aspects of biology. However, the role of a polysaccharide derived from Amusium pleuronectes on potential hepatoprotective effects remains unclear. MATERIAL AND METHODS A water-soluble polysaccharide was isolated from Amusium pleuronectes (APS-1) using ultrasound-assisted hot-water extraction. The molecular weight of APS-1 was approximately 11.7 kDa and was determined by calibration with dextran. APS-1 was analyzed by high-performance liquid chromatography (HPLC), and mainly consisted of a uniform glucose polymer...
March 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29541874/update-on-antiphospholipid-syndrome-ten-topics-in-2017
#11
REVIEW
Ilaria Cavazzana, Laura Andreoli, Maarteen Limper, Franco Franceschini, Angela Tincani
PURPOSE OF REVIEW: This review focuses on new clinical aspects of antiphospholipid syndrome (APS) in the last 5 years. RECENT FINDINGS: The pathogenesis of APS is related to endothelial activation by mechanisms other than autoantibody-mediated massive coagulation. These include Toll-like receptors, the m-TORC pathway, and neutrophil activation, inducing an uncontrolled inflammatory cascade. Given these new pathogenetic hypotheses, the treatment of APS could be directed towards a fine balance between anticoagulation and immunomodulation...
March 15, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29535204/interactions-between-the-hepatitis-c-virus-nonstructural-2-protein-and-host-adaptor-proteins-1-and-4-orchestrate-virus-release
#12
Fei Xiao, Stanley Wang, Rina Barouch-Bentov, Gregory Neveu, Szuyuan Pu, Melanie Beer, Stanford Schor, Sathish Kumar, Vlad Nicolaescu, Brett D Lindenbach, Glenn Randall, Shirit Einav
Hepatitis C virus (HCV) spreads via secreted cell-free particles or direct cell-to-cell transmission. Yet, virus-host determinants governing differential intracellular trafficking of cell-free- and cell-to-cell-transmitted virus remain unknown. The host adaptor proteins (APs) AP-1A, AP-1B, and AP-4 traffic in post-Golgi compartments, and the latter two are implicated in basolateral sorting. We reported that AP-1A mediates HCV trafficking during release, whereas the endocytic adaptor AP-2 mediates entry and assembly...
March 13, 2018: MBio
https://www.readbyqxmd.com/read/29510235/treatment-of-antiphospholipid-syndrome-beyond-anticoagulation
#13
Chrisanna Dobrowolski, Doruk Erkan
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder marked by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). At the present time, treatment is primarily focused on anticoagulation. However, there is increasing awareness of the mechanisms involved in APS pathogenesis, which has led to the trial of novel therapies targeting those mechanisms. Following a brief review of the etiopathogenesis of and current management strategies in APS, this paper focuses on the evidence for these potential, targeted APS treatments, e...
March 3, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29499349/recent-advances-in-aptamer-armed-multimodal-theranostic-nanosystems-for-imaging-and-targeted-therapy-of-cancer
#14
REVIEW
Somayeh Vandghanooni, Morteza Eskandani, Jaleh Barar, Yadollah Omidi
The side effects of chemotherapeutics during the course of cancer treatment limit their clinical outcomes. The most important mission of the modern cancer therapy modalities is the delivery of anticancer drugs specifically to the target cells/tissue in order to avoid/reduce any inadvertent non-specific impacts on the healthy normal cells. Nanocarriers decorated with a designated targeting ligand such as aptamers (Aps) and antibodies (Abs) are able to deliver cargo molecules to the target cells/tissue without affecting other neighboring cells, resulting in an improved treatment of cancer...
February 27, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29490425/aspidosperma-pyrifolium-mart-neuroprotective-antioxidant-and-anti-inflammatory-effects-in-a-parkinson-s-disease-model-in-rats
#15
Dayane P de Araújo, Patrícia C N Nogueira, Alan Diego C Santos, Roberta de Oliveira Costa, Jalles D de Lucena, Carlos Vinicius Jataí Gadelha-Filho, Francisco Arnaldo V Lima, Kelly Rose T Neves, Luzia Kalyne Almeida M Leal, Edilberto R Silveira, Glauce S B Viana
OBJECTIVES: Aspidosperma species are used for several diseases, especially for malaria in Brazil. Although the genus is object of pharmacological studies, almost none are found on Aspidosperma pyrifolium. We investigate neuroprotective, antioxidant and anti-inflammatory properties of the APSE-Aq fraction (benzoic acid glycosylated derivative) on Parkinson's disease model. METHODS: Male Wistar rats were subjected to a 6-hydroxydopamine injection into the right striatum and treated or not with APSE-Aq (100 or 200 mg/kg, p...
February 28, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29481521/proliferation-and-committed-differentiation-into-dopamine-neurons-of-neural-stem-cells-induced-by-the-active-ingredients-of-radix-astragali
#16
Han Gao, Lianrong Dou, Liang Shan, Yan Sun, Wentao Li
Neural stem cells (NSCs) are important cellular sources of transplantation therapies for Parkinson's disease. This study aimed to determine the effects of extracts of radix astragali on the proliferation and differentiation into dopamine (DA) neurons in NSCs. NSCs were dealt with astragaloside IV (ASI), astragalus polysaccharide (APS), and astraisoflavan (ASF), the main active ingredients of radix astragali. First, the results from cell-count kit-8 (CCK-8) assay showed that ASI, ASF, and APS had positive effects on the proliferation of NSCs...
February 23, 2018: Neuroreport
https://www.readbyqxmd.com/read/29474817/activation-of-the-unfolded-protein-response-downregulates-cardiac-ion-channels-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#17
Man Liu, Guangbin Shi, Anyu Zhou, Cassady E Rupert, Kareen L K Coulombe, Samuel C Dudley
RATIONALE: Heart failure is characterized by electrical remodeling that contributes to arrhythmic risk. The unfolded protein response (UPR) is active in heart failure and can decrease protein levels by increasing mRNA decay, accelerating protein degradation, and inhibiting protein translation. OBJECTIVE: Therefore, we investigated whether the UPR downregulated cardiac ion channels that may contribute to arrhythmogenic electrical remodeling. METHODS: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were used to study cardiac ion channels...
February 21, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29457593/characterization-study-and-optimization-of-swelling-behavior-for-p-hema-co-eudragit-l-100-hydrogels-by-using-taguchi-method
#18
Hediye Irem Ozgunduz, Abdullah Bilal Ozturk, Hava Gizem Kandilci, Nil Acarali
The aim of this study is to produce the smart hydrogel to use insulin release for human body. p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragait L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker. The structures of hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis. In this way, optimum synthesis conditions were determined for p(HEMA-co-Eudragit L-100) hydrogels by using Taguchi method as an optimization method...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29451664/update-on-antiphospholipid-antibody-syndrome
#19
Michelle Remião Ugolini Lopes, Adriana Danowski, Andreas Funke, Jozelia Rêgo, Roger Levy, Danieli Castro Oliveira de Andrade
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by antiphospholipid antibodies (aPL) associated with thrombosis and/or pregnancy morbidity. Most APS events are directly related to thrombotic events, which may affect small, medium or large vessels. Other clinical features like thrombocytopenia, nephropathy, cardiac valve disease, cognitive dysfunction and skin ulcers (called non-criteria manifestations) add significant morbidity to this syndrome and represent clinical situations that are challenging...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29451405/astragalus-polysaccharide-alleviates-lps-induced-inflammation-injury-by-regulating-mir-127-in-h9c2-cardiomyoblasts
#20
Qi Ren, Shaojun Zhao, Changjie Ren, Zhen Ma
Astragalus polysaccharide (APS) has been widely reported to play an important role in inflammatory response. In this study, we aimed to explore the effects and underlying mechanisms of APS on lipopolysaccharide (LPS)-induced inflammation injury in H9c2 cardiomyoblasts. H9c2 cells were treated with different concentrations of APS, and cell viability was detected by the Cell Counting Kit-8 (CCK-8) assay. Then, the effect of APS on cell viability and apoptosis induced by LPS was determined by CCK-8, flow cytometry, and western blot...
January 2018: International Journal of Immunopathology and Pharmacology
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