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https://www.readbyqxmd.com/read/29457593/characterization-study-and-optimization-of-swelling-behavior-for-p-hema-co-eudragit-l-100-hydrogels-by-using-taguchi-method
#1
Hediye Irem Ozgunduz, Abdullah Bilal Ozturk, Hava Gizem Kandilci, Nil Acarali
The aim of this study is to produce the smart hydrogel to use insulin release for human body. p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragait L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker. The structures of hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis. In this way, optimum synthesis conditions were determined for p(HEMA-co-Eudragit L-100) hydrogels by using Taguchi method as an optimization method...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29451664/update-on-antiphospholipid-antibody-syndrome
#2
Michelle Remião Ugolini Lopes, Adriana Danowski, Andreas Funke, Jozelia Rêgo, Roger Levy, Danieli Castro Oliveira de Andrade
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by antiphospholipid antibodies (aPL) associated with thrombosis and/or pregnancy morbidity. Most APS events are directly related to thrombotic events, which may affect small, medium or large vessels. Other clinical features like thrombocytopenia, nephropathy, cardiac valve disease, cognitive dysfunction and skin ulcers (called non-criteria manifestations) add significant morbidity to this syndrome and represent clinical situations that are challenging...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29451405/astragalus-polysaccharide-alleviates-lps-induced-inflammation-injury-by-regulating-mir-127-in-h9c2-cardiomyoblasts
#3
Qi Ren, Shaojun Zhao, Changjie Ren, Zhen Ma
Astragalus polysaccharide (APS) has been widely reported to play an important role in inflammatory response. In this study, we aimed to explore the effects and underlying mechanisms of APS on lipopolysaccharide (LPS)-induced inflammation injury in H9c2 cardiomyoblasts. H9c2 cells were treated with different concentrations of APS, and cell viability was detected by the Cell Counting Kit-8 (CCK-8) assay. Then, the effect of APS on cell viability and apoptosis induced by LPS was determined by CCK-8, flow cytometry, and western blot...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29449131/the-treatment-of-anti-phospholipid-syndrome-a-comprehensive-clinical-approach
#4
REVIEW
Cecilia Beatrice Chighizola, Laura Andreoli, Maria Gerosa, Angela Tincani, Amelia Ruffatti, Pier Luigi Meroni
Anti-phospholipid syndrome (APS) is an acquired pro-thrombotic autoimmune disease that predisposes to thrombotic events and/or obstetric complications, in the persistent presence of anti-phospholipid antibodies (aPL). Life long moderate-intensity anticoagulation is the option of choice for aPL-positive patients with a previous thrombosis; critical issues concern the management of those with a history of arterial event due to the high rate of recurrence. Alternatives comprise anti-platelet agents and high-intensity anticoagulation...
February 12, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29445837/alkaline-phosphatases-in-the-complex-chronic-kidney-disease-mineral-and-bone-disorders
#5
Jordi Bover, Pablo Ureña, Armando Aguilar, Sandro Mazzaferro, Silvia Benito, Víctor López-Báez, Alejandra Ramos, Iara daSilva, Mario Cozzolino
Alkaline phosphatases (APs) remove the phosphate (dephosphorylation) needed in multiple metabolic processes (from many molecules such as proteins, nucleotides, or pyrophosphate). Therefore, APs are important for bone mineralization but paradoxically they can also be deleterious for other processes, such as vascular calcification and the increasingly known cross-talk between bone and vessels. A proper balance between beneficial and harmful activities is further complicated in the context of chronic kidney disease (CKD)...
February 14, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29443561/building-bridges-to-a-brighter-tomorrow-a-systematic-evidence-review-of-interventions-that-prepare-adolescents-for-adulthood
#6
Barri B Burrus, Kathleen Krieger, Regina Rutledge, Alexander Rabre, Sarah Axelson, Audra Miller, LeBretia White, Christine Jackson
BACKGROUND: Data suggest that adverse social determinants during adolescence can set in motion a lifetime of poor social and health outcomes. Vulnerable youths are at particularly high risk in this regard. OBJECTIVES: To identify and assess the current evidence base for adolescent-focused interventions designed to influence adulthood preparation that could affect longer-term social determinants. SEARCH METHODS: Using a systematic review methodology, we conducted an initial assessment of intervention evaluations targeting 6 adulthood preparation subject (APS) areas to assess the quality and character of the evidence base...
February 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29428997/synthesis-of-zeolite-membranes-on-calcium-silicate-support-and-their-bioactive-response
#7
A Medina-Ramírez, A A Flores-Díaz, B Ruiz Camacho, G García-Ruiz
The synthesis of calcium silicate supported zeolite membrane was carried out by second growth method. The chemical nature of the functionalizing agent on the formation of homogenous zeolite membrane was evaluated. One monomer and two cationic polymers were used: 3-aminopropyltriethoxysilane (APS), polyethylenimine (PEI) and polydiallyldimethylammonium chloride (PDDA). The support was subjected to chemical functionalization and then it was rubbed with zeolite crystals. The W zeolite was used as zeolite seed in two different Si/Al ratios...
February 10, 2018: Progress in Biomaterials
https://www.readbyqxmd.com/read/29402471/direct-oral-anticoagulant-use-in-patients-with-thrombophilia-antiphospholipid-syndrome-or-venous-thrombosis-of-unusual-sites-a-narrative-review
#8
REVIEW
Laurent Bertoletti, Ygal Benhamou, Yannick Béjot, Sylvestre Marechaux, Saida Cheggour, Boris Aleil, Nicolas Lellouche, Jean-Guillaume Dillinger, Aurélien Delluc
Direct oral anticoagulants (DOACs) are indicated in the treatment and prevention of venous thromboembolism (VTE). However, the use of DOACs in unusual VTE, including cerebral venous thrombosis (CVT) and splanchnic venous thrombosis (SVT), and in patients with biological thrombophilia including minor thrombophilia (Factor V Leiden and prothrombin G20210A), major innate thrombophilia (protein C and S deficiency, and antithrombin) and major acquired thrombophilia (antiphospholipid syndrome [APS]), remains controversial due to the paucity of available data...
February 2, 2018: Blood Reviews
https://www.readbyqxmd.com/read/29390901/tricyclic-coumarin-sulphonate-derivatives-with-alkaline-phosphatase-inhibitory-effects-in-vitro-and-docking-studies
#9
Jamshed Iqbal, Mohammed I El-Gamal, Syeda Abida Ejaz, Joanna Lecka, Jean Sévigny, Chang-Hyun Oh
Tissue-nonspecific alkaline phosphatase (TNAP) is an important isozyme of alkaline phosphatases, which plays different pivotal roles within the human body. Most importantly, it is responsible for maintaining the balanced ratio of phosphate and inorganic pyrophosphate, thus regulates the extracellular matrix calcification during bone formation and growth. The elevated level of TNAP has been linked to vascular calcification and end-stage renal diseases. Consequently, there is a need to search for highly potent and selective inhibitors of alkaline phosphatases (APs) for treatment of disorders associated with the over-expression of APs...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29366630/an-advanced-uracil-dna-glycosylase-supplemented-loop-mediated-isothermal-amplification-udg-lamp-technique-used-in-the-sensitive-and-specific-detection-of-cryptosporidium-parvum-cryptosporidium-hominis-and-cryptosporidium-meleagridis-in-aids-patients
#10
Shirzad Fallahi, Seyedeh Fatemeh Moosavi, Azadeh Karimi, Ali Sharafi Chegeni, Mohammad Saki, Parsa Namdari, Mohammad Menati Rashno, Ali Mohamad Varzi, Mohammad Javad Tarrahi, Mohammad Almasian
The rapid and accurate detection of Cryptosporidium spp. is critically important for the prevention and timely treatment of cryptosporidiosis in AIDS patients (APs). This study was conducted to examine a UDG-LAMP technique for the first time to diagnose cryptosporidiosis in APs. After collecting demographic and clinical data, three stool samples were collected from the participants (120 volunteering APs). The microscopic examination of stained smears using the acid-fast method and the UDG-LAMP assay were performed for each sample...
December 24, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29355626/transgenerational-endotoxin-tolerance-like-effect-caused-by-paternal-dietary-astragalus-polysaccharides-in-broilers-jejunum
#11
Yulong Li, Xinyu Lei, Wei Guo, Shengru Wu, Yulan Duan, Xin Yang, Xiaojun Yang
To learn the nutri-epigenetics role of Astragalus polysaccharides (APS), we designed and studied the transgenerational effect of paternal dietary APS supplementation in chickens. 160 Avein breeder cocks were randomly allocated into 5 groups and fed with 0, 0.01, 0.1, 1, and 10 g/kg APS supplement, respectively. Sperm of breeder cocks was collected and used for hatching experiment to get broiler chickens when the cocks at 40-weeks-old. It showed that the paternal dietary 10 g/kg APS could transgenerational promote growth performance and jejunal tissue morphology of chickens...
January 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29351467/from-ionic-to-cellular-variability-in-human-atrial-myocytes-an-integrative-computational-and-experimental-study
#12
Anna Muszkiewicz, Xing Liu, Alfonso Bueno-Orovio, Brodie A J Lawson, Kevin Burrage, Barbara Casadei, Blanca Rodriguez
Variability refers to differences in physiological function between individuals, which may translate into different disease susceptibility and treatment efficacy. Experiments in human cardiomyocytes face wide variability and restricted tissue access; under these conditions computational models are a useful complementary tool. We conducted a computational and experimental investigation in cardiomyocytes isolated from samples of the right atrial appendage of patients undergoing cardiac surgery to evaluate the impact of variability in action potentials (APs) and sub-cellular ionic densities on calcium transient dynamics...
December 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29321641/antiphospholipid-syndrome
#13
REVIEW
Karen Schreiber, Savino Sciascia, Philip G de Groot, Katrien Devreese, Soren Jacobsen, Guillermo Ruiz-Irastroza, Jane E Salmon, Yehuda Shoenfeld, Ora Shovman, Beverley J Hunt
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and anti-β2-glycoprotein 1 antibodies. APS can present with a variety of clinical phenotypes, including thrombosis in the veins, arteries and microvasculature as well as obstetrical complications. The pathophysiological hallmark is thrombosis, but other factors such as complement activation might be important. Prevention of thrombotic manifestations associated with APS includes lifestyle changes and, in individuals at high risk, low-dose aspirin...
January 11, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29303800/prescribing-trends-of-atypical-antipsychotic-drugs-in-an-outpatient-unit-of-a-child-and-adolescent-clinic-in-turkey
#14
Çiğdem Yektaş, Ali Evren Tufan
OBJECTIVE: Use of antipsychotic agents in the management of various psychopathologies in Child and Adolescent Psychiatric practice is gradually increasing. This study aimed to evaluate the sociodemographic and clinical features of children and adolescents who applied to an outpatient clinic of child and adolescent psychiatry department in Turkey and were prescribed atypical antipsychotics. METHOD: Patients with prescription codes of ATC N05A (except N05AN lithium) were accepted to denote those with atypical antipsychotic treatment...
January 5, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29300536/autoimmune-polyendocrine-syndrome-type-2-in-patient-with-severe-allergic-asthma-treated-with-omalizumab
#15
Anna Rams, Marek Żółciński, Weronika Zastrzeżyńska, Stanisław Polański, Agnieszka Serafin, Joanna Wilańska, Jacek Musiał, Stanisława Bazan-Socha
Asthma therapy with monoclonal antibodies is a promising and effective approach for those with a severe and refractory type of disease. Although such a targeted therapy is considered to be safe, unusual complications may occur. We present a case of a 45 year-old female patient with severe allergic asthma and chronic spontaneous urticaria, who developed autoimmune polyendocrine syndrome type 2 (APS-2) after 26 months of omalizumab administration. The patient was diagnosed with primary adrenal insufficiency (Addison's disease) and Hashimoto's thyroiditis accompanied by autoimmune atrophic gastritis...
January 4, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29295822/runx2-overexpression-compromises-bone-quality-in-acromegalic-patients
#16
Maria Teresa Valenti, Monica Mottes, Samuele Cheri, Michela Deiana, Valentina Micheletti, Elisa Cosaro, Maria Vittoria Davì, Giuseppe Francia, Luca Dalle Carbonare
Acromegalic patients, characterized by excessive secretion of GH and IGF-1, show a high fracture risk but Bone Mineral Density is a poor predictor for bone fractures in these patients. The effects of an excess of GH/IGF1 on skeleton as well as on osteogenic progenitors, i.e. mesenchymal stem cells, have not been investigated in these patients. We aimed to elucidate the skeletal conditions of acromegalic patients by means of bone microarchitecture analysis and evaluation of MSCs osteogenic commitment. In particular, we performed histomorphometric analyses and we quantified the expression levels of the osteogenic transcription factor RUNX2 in circulating MSCs...
January 2, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29279807/an-autologous-anti-inflammatory-protein-solution-yielded-a-favorable-safety-profile-and-significant-pain-relief-in-an-open-label-pilot-study-of-patients-with-osteoarthritis
#17
Jason Hix, Mark Klaassen, Ryan Foreman, Edith Cullen, Krista Toler, William King, Jennifer Woodell-May
Osteoarthritis (OA) is a progressive and degenerative disease, which may result in significant pain and decreased quality of life. Recent updates in our understanding of OA have demonstrated that it is a whole joint disease that has many similarities to an unhealed wound containing inflammatory cytokines. The nSTRIDE Autologous Protein Solution (APS) Kit is a medical device under development for the treatment of OA. The APS Kit processes a patient's own blood at the point of care to contain high concentrations of anti-inflammatory cytokines and anabolic growth factors...
2017: BioResearch Open Access
https://www.readbyqxmd.com/read/29241089/association-of-psychosis-with-antiphospholipid-antibody-syndrome-a-systematic-review-of-clinical-studies
#18
Asma Hallab, Sadiq Naveed, Ahmed Altibi, Mariam Abdelkhalek, Huyen Thi Ngo, Thao Phuong Le, Kenji Hirayama, Nguyen Tien Huy
OBJECTIVE: In this systematic review, we reviewed the association between Antiphospholipid antibody syndrome (APS) and psychosis and focused on the prevalence, clinical presentation, immunologic and neurological workup, treatment options, and clinical outcomes. METHODOLOGY: We performed this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)'s guidelines. We searched eight databases for potential articles and manually searched references and relevant articles of included studies...
January 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29225515/anticancer-activity-of-astragalus-polysaccharide-in-human-non-small-cell-lung-cancer-cells
#19
Chao-Yan Wu, Yuan Ke, Yi-Fei Zeng, Ying-Wen Zhang, Hai-Jun Yu
Background: We have reported that Chinese herbs Astragalus polysaccharide (APS) can inhibit nuclear factor kappaB (NF-κB) activity during the development of diabetic nephropathy in mice. NF-κB plays important roles in genesis, growth, development and metastasis of cancer. NF-κB is also involved in the development of treatment resistance in tumors. Here we investigated the antitumor activity of APS in human non-small cell lung cells (A549 and NCI-H358) and the related mechanisms of action...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29214126/pharmacologic-complement-inhibition-in-clinical-transplantation
#20
REVIEW
Vasishta S Tatapudi, Robert A Montgomery
Purpose of Review: Over the past two decades, significant strides made in our understanding of the etiology of antibody-mediated rejection (AMR) in transplantation have put the complement system in the spotlight. Here, we review recent progress made in the field of pharmacologic complement inhibition in clinical transplantation and aim to understand the impact of this therapeutic approach on outcomes in transplant recipients. Recent Findings: Encouraged by the success of agents targeting the complement cascade in disorders of unrestrained complement activation like paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), investigators are testing the safety and efficacy of pharmacologic complement blockade in mitigating allograft injury in conditions ranging from AMR to recurrent post-transplant aHUS, C3 glomerulopathies and antiphospholipid anti-body syndrome (APS)...
2017: Current Transplantation Reports
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