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https://www.readbyqxmd.com/read/27932365/danish-register-based-study-on-the-association-between-specific-antipsychotic-drugs-and-fractures-in-elderly-individuals
#1
Maia Torstensson, Katja Leth-Møller, Charlotte Andersson, Christian Torp-Pedersen, Gunnar Hilmar Gislason, Ellen Astrid Holm
BACKGROUND: antipsychotic drugs (APs) have been associated with falls and fractures in elderly individuals but limited knowledge on specific drugs exist. OBJECTIVE: to investigate the association between individual APs and fractures in elderly persons. DESIGN AND SETTING: nationwide register-based cohort study. SUBJECTS: all Danish individuals aged ≥65 who had not been in treatment with any AP in the year before inclusion...
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27927881/brain-abscess-due-to-listeria-monocytogenes-after-hellp-syndrome-in-a-patient-with-antiphospholipid-syndrome
#2
A Fervienza, M Bodro, P Castro, S Hernández, I Teixidó, G Espinosa, R Cervera
OBJECTIVE: To illustrate an unusual case of Listeria cerebral abscess. MATERIAL AND METHODS: A 32-year-old pregnant woman with thrombotic antiphospholipid syndrome (APS) received corticotherapy for two weeks due to hemolysis, elevated liver enzymes, low platelet (HELLP) syndrome. After delivery she presented with neurological symptoms and fever. RESULTS: The MRI scan confirmed the presence of a brain abscess, and Listeria monocytogenes was isolated in blood cultures...
December 6, 2016: Lupus
https://www.readbyqxmd.com/read/27913227/assisted-partner-services-for-hiv-in-kenya-a-cluster-randomised-controlled-trial
#3
Peter Cherutich, Matthew R Golden, Beatrice Wamuti, Barbra A Richardson, Kristjana H Ásbjörnsdóttir, Felix A Otieno, Ann Ng'ang'a, Peter Maingi Mutiti, Paul Macharia, Betsy Sambai, Matt Dunbar, David Bukusi, Carey Farquhar
BACKGROUND: Assisted partner services for index patients with HIV infections involves elicitation of information about sex partners and contacting them to ensure that they test for HIV and link to care. Assisted partner services are not widely available in Africa. We aimed to establish whether or not assisted partner services increase HIV testing, diagnoses, and linkage to care among sex partners of people with HIV infections in Kenya. METHODS: In this cluster randomised controlled trial, we recruited non-pregnant adults aged at least 18 years with newly or recently diagnosed HIV without a recent history of intimate partner violence who had not yet or had only recently linked to HIV care from 18 HIV testing services clinics in Kenya...
November 29, 2016: Lancet HIV
https://www.readbyqxmd.com/read/27902889/the-complexities-of-doctor-patient-family-communication-in-an-asian-oncology-setting-concordance-and-discordance-among-patient-preferences-family-preferences-and-perceived-and-actual-communication
#4
Geok Ling Lee, Irene Teo, Ravindran Kanesvaran
This article reports on a pilot study that examined the complexities of doctor-patient-family communication in an oncology setting in Singapore. Twenty consultation visits were audio-recorded and a postconsultation questionnaire was administered to patients and their accompanying person (AP) to examine their communication preferences. Patients and APs rated physician expertise and message content as highly important; supportive elements of the communication were rated as less important. Patients preferred information concerning their condition, while APs preferred information regarding treatment options...
November 30, 2016: Health Communication
https://www.readbyqxmd.com/read/27902477/astragalus-polysaccharide-restores-autophagic-flux-and-improves-cardiomyocyte-function-in-doxorubicin-induced-cardiotoxicity
#5
Yuan Cao, Tao Shen, Xiuqing Huang, Yajun Lin, Beidong Chen, Jing Pang, Guoping Li, Que Wang, Sylvia Zohrabian, Chao Duan, Yang Ruan, Yong Man, Shu Wang, Jian Li
Doxorubicin (adriamycin), an anthracycline antibiotic, is commonly used to treat many types of solid and hematological malignancies. Unfortunately, clinical usage of doxorubicin is limited due to the associated acute and chronic cardiotoxicity. Previous studies demonstrated that Astragalus polysaccharide (APS), the extracts of Astragalus membranaceus, had strong anti-tumor activities and anti-inflammatory effects. However, whether APS could mitigate chemotherapy-induced cardiotoxicity is unclear thus far. We used a doxorubicin-induced neonatal rat cardiomyocyte injury model and a mouse heart failure model to explore the function of APS...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27897983/effects-of-polysaccharide-elicitors-from-endophytic-fusarium-oxysporum-fat9-on-the-growth-flavonoid-accumulation-and-antioxidant-property-of-fagopyrum-tataricum-sprout-cultures
#6
Lingyun Zhong, Bei Niu, Lin Tang, Fang Chen, Gang Zhao, Jianglin Zhao
The purpose of this study was to evaluate the effects of four different fungal polysaccharides, named water-extracted mycelia polysaccharide (WPS), sodium hydroxide-extracted mycelia polysaccharide (SPS), hydrochloric-extracted mycelia polysaccharide (APS), and exo-polysaccharide (EPS) obtained from the endophytic Fusarium oxysporum Fat9 on the sprout growth, flavonoid accumulation, and antioxidant capacity of tartary buckwheat. Without visible changes in the appearance of the sprouts, the exogenous polysaccharide elicitors strongly stimulated sprout growth and flavonoid production, and the stimulation effect was closely related with the polysaccharide (PS) species and its treatment dosage...
November 25, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27884691/aapt-diagnostic-criteria-for-chronic-cancer-pain-conditions
#7
REVIEW
Judith A Paice, Matt Mulvey, Michael Bennett, Patrick M Dougherty, John T Farrar, Patrick W Mantyh, Christine Miaskowski, Brian Schmidt, Thomas J Smith
: Chronic cancer pain is a serious complication of malignancy or its treatment. Currently, no comprehensive, universally accepted cancer pain classification system exists. Clarity in classification of common cancer pain syndromes would improve clinical assessment and management. Moreover, an evidence-based taxonomy would enhance cancer pain research efforts by providing consistent diagnostic criteria, ensuring comparability across clinical trials. As part of a collaborative effort between the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks (ACTTION) and the American Pain Society (APS), the ACTTION-APS Pain Taxonomy (AAPT) initiative worked to develop the characteristics of an optimal diagnostic system...
November 21, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27868072/the-role-of-tlr4-on-b-cell-activation-and-anti-%C3%AE-2gpi-antibody-production-in-the-antiphospholipid-syndrome
#8
REVIEW
Si Cheng, Haibo Wang, Hong Zhou
High titer of anti-β2-glycoprotein I antibodies (anti-β2GPI Ab) plays a pathogenic role in antiphospholipid syndrome (APS). Numerous studies have focused on the pathological mechanism in APS; however, little attention is paid to the immune mechanism of production of anti-β2GPI antibodies in APS. Our previous study demonstrated that Toll-like receptor 4 (TLR4) plays a vital role in the maturation of bone marrow-derived dendritic cells (BMDCs) from the mice immunized with human β2-glycoprotein I (β2GPI)...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27865435/-the-pulse-mass-index-as-a-predictor-of-cardiovascular-events-in-women-with-systemic-lupus-erythematosus
#9
Elsy Aidé García-Villegas, Horacio Márquez-González, Luis Felipe Flores-Suárez, Antonio Rafael Villa-Romero
BACKGROUND: Patients with systemic lupus erythematosus (SLE) have 3times the risk of death compared to the rest of the population, with cardiovascular events (CVD) being one of the main causes. Índices such as waist-height (W-Ht I), waist-hip (W-Hp I) and pulse-mass (PMI) predict CVD, though the behaviour is unknown in patients with SLE. The aim of this study was to determine the prognostic value of PMI in the development of CVD in premenopausal women with SLE. METHODOLOGY: Cohort study...
November 16, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27861383/living-donor-renal-transplantation-in-patients-with-antiphospholipid-syndrome-a-case-report
#10
Ji Yoon Choi, Joo Hee Jung, Sung Shin, Young Hoon Kim, Duck Jong Han
INTRODUCTION: Antiphospholipid syndrome (APS), autoantibodies directed against phospholipid-binding proteins are associated with cause vascular thrombosis. Patients with APS requiring renal transplantation are at risk of early graft loss due to arterial or venous thrombosis, or thrombotic microangiopathy (TMA). Here, we report 3 cases of successful renal transplantation in patients with APS. CLINICAL FINDINGS: A 53-year-old man with end-stage renal disease (ESRD) had experienced bilateral deep venous thrombosis (DVT) in the lower extremities 16 years ago and was administered warfarin...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27861123/tecrl-a-new-life-threatening-inherited-arrhythmia-gene-associated-with-overlapping-clinical-features-of-both-lqts-and-cpvt
#11
Harsha D Devalla, Roselle Gélinas, Elhadi H Aburawi, Abdelaziz Beqqali, Philippe Goyette, Christian Freund, Marie-A Chaix, Rafik Tadros, Hui Jiang, Antony Le Béchec, Jantine J Monshouwer-Kloots, Tom Zwetsloot, Georgios Kosmidis, Frédéric Latour, Azadeh Alikashani, Maaike Hoekstra, Jurg Schlaepfer, Christine L Mummery, Brian Stevenson, Zoltan Kutalik, Antoine Af de Vries, Léna Rivard, Arthur Am Wilde, Mario Talajic, Arie O Verkerk, Lihadh Al-Gazali, John D Rioux, Zahurul A Bhuiyan, Robert Passier
Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole-exome sequencing (WES) was carried out on patients from three different families that presented with life-threatening arrhythmias and high risk of sudden cardiac death (SCD). Two French Canadian probands carried identical homozygous rare variant in TECRL gene (p.Arg196Gln), which encodes the trans-2,3-enoyl-CoA reductase-like protein. Both patients had cardiac arrest, stress-induced atrial and ventricular tachycardia, and QT prolongation on adrenergic stimulation...
December 1, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27847230/fate-of-emerging-and-priority-micropollutants-during-the-sewage-sludge-treatment-case-study-of-paris-conurbation-part-1-contamination-of-the-different-types-of-sewage-sludge
#12
R Mailler, J Gasperi, D Patureau, E Vulliet, N Delgenes, A Danel, S Deshayes, V Eudes, S Guerin, R Moilleron, G Chebbo, V Rocher
This article provides data on the contamination of different kinds of sludge (raw, centrifuged, digested, thermally dried sludge and sludge cake) from Paris conurbation by 71 various pollutants including pharmaceutical products (PHPs), hormones, perfluorinated acids (PFAs), linear alkylbenzene sulfonate (LAS), alkylphenols (APs), phthalates (PAEs), polycyclic aromatic hydrocarbons (PAHs) and polychlorobiphenyls (PCBs). Very high contents of LAS (0.1-10g/kg dry matter - DM) compared to other compounds were found in all types of sludge followed by DEHP (10-100mg/kg DM) and fluoroquinolones (1-100mg/kg DM)...
November 12, 2016: Waste Management
https://www.readbyqxmd.com/read/27844290/potentiation-of-paclitaxel-induced-pain-syndrome-in-mice-by-angiotensin-i-converting-enzyme-inhibition-and-involvement-of-kinins
#13
Indiara Brusco, Cássia Regina Silva, Gabriela Trevisan, Camila de Campos Velho Gewehr, Flávia Karine Rigo, Lidia La Rocca Tamiozzo, Mateus Fortes Rossato, Raquel Tonello, Gerusa Duarte Dalmolin, Daniela de Almeida Cabrini, Marcus Vinícius Gomez, Juliano Ferreira, Sara Marchesan Oliveira
Paclitaxel is a chemotherapeutic agent used to treat solid tumours. However, it causes an acute and neuropathic pain syndrome that limits its use. Among the mechanisms involved in neuropathic pain caused by paclitaxel is activation of kinin receptors. Angiotensin converting enzyme (ACE) inhibitors can enhance kinin receptor signalling. The goal of this study was to evaluate the role of kinins on paclitaxel-associated acute pain syndromes (P-APS) and the effect of ACE inhibition on P-APS and paclitaxel-associated chronic peripheral neuropathy (P-CPN) in mice...
November 14, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27829889/cross-linked-cyclodextrin-based-material-for-treatment-of-metals-and-organic-substances-present-in-industrial-discharge-waters
#14
Élise Euvrard, Nadia Morin-Crini, Coline Druart, Justine Bugnet, Bernard Martel, Cesare Cosentino, Virginie Moutarlier, Grégorio Crini
In this study, a polymer, prepared by crosslinking cyclodextrin (CD) by means of a polycarboxylic acid, was used for the removal of pollutants from spiked solutions and discharge waters from the surface treatment industry. In spiked solutions containing five metals, sixteen polycyclic aromatic hydrocarbons (PAH) and three alkylphenols (AP), the material exhibited high adsorption capacities: >99% of Co(2+), Ni(2+) and Zn(2+) were removed, between 65 and 82% of the PAHs, as well as 69 to 90% of the APs. Due to the structure of the polymer and its specific characteristics, such as the presence of carboxylic groups and CD cavities, the adsorption mechanism involves four main interactions: ion exchange, electrostatic interactions and precipitation for metal removal, and inclusion complexes for organics removal...
2016: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27823895/impact-of-residual-mitral-regurgitation-after-mitraclip-implantation
#15
Hidehiro Kaneko, Michael Neuss, Jens Weissenborn, Christian Butter
BACKGROUND: MitraClip (MC) is an alternative treatment for mitral regurgitation (MR). Although residual MR is common after MC, little was known about the impact of residual MR after MC. METHODS: We examined 255 consecutive patients who underwent MC. The primary endpoint was the composite endpoint including all-cause death, left ventricular (LV) assist device, and mitral valve surgery. RESULTS: Procedure failure defined as unsuccessful MC implantation (n=6) and residual MR ≥3+ (n=19) was associated with worse outcomes including the primary endpoint and all-cause death than those with acute procedure success (APS) defined as residual MR 2+ (n=125) or 1+ (n=105)...
October 24, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27821204/cannabis-induced-attenuated-psychotic-symptoms-implications-for-prognosis-in-young-people-at-ultra-high-risk-for-psychosis
#16
M J McHugh, P D McGorry, A R Yung, A Lin, S J Wood, J A Hartmann, B Nelson
BACKGROUND: Cannabis use shows a robust dose-dependent relationship with psychosis risk among the general population. Despite this, it has been difficult to link cannabis use with risk for transitioning to a psychotic disorder among individuals at ultra-high risk (UHR) for psychosis. The present study examined UHR transition risk as a function of cannabis use characteristics which vary substantially between individuals including age of first use, cannabis abuse severity and a history of cannabis-induced attenuated psychotic symptoms (APS)...
November 8, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27815005/valuing-investments-in-sustainable-land-management-in-the-upper-tana-river-basin-kenya
#17
Adrian L Vogl, Benjamin P Bryant, Johannes E Hunink, Stacie Wolny, Colin Apse, Peter Droogers
We analyze the impacts of investments in sustainable land use practices on ecosystem services in the Upper Tana basin, Kenya. This work supports implementation of the Upper Tana-Nairobi Water Fund, a public-private partnership to safeguard ecosystem service provision and food security. We apply an integrated modelling framework, building on local knowledge and previous field- and model-based studies, to link biophysical landscape changes at high temporal and spatial resolution to economic benefits for key actors in the basin...
November 1, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27807306/efficacy-of-dabigatran-versus-warfarin-in-patients-with-acute-venous-thromboembolism-in-the-presence-of-thrombophilia-findings-from-re-cover%C3%A2-re-cover%C3%A2-ii-and-re-medy%C3%A2
#18
Samuel Z Goldhaber, Henry Eriksson, Ajay Kakkar, Sebastian Schellong, Martin Feuring, Mandy Fraessdorf, Joerg Kreuzer, Elke Schueler, Sam Schulman
It is unclear whether thrombophilia causes resistance to anticoagulant therapy. Post hoc analyses of data from RE-COVER(®), RE-COVER(™) II, and RE-MEDY(™) were performed to compare dabigatran etexilate with warfarin for the treatment and prevention of venous thromboembolism (VTE) in patients with thrombophilia or antiphospholipid antibody syndrome (APS). There were no significant differences in symptomatic VTE/VTE-related deaths between dabigatran etexilate and warfarin in patients with or without thrombophilia...
December 2016: Vascular Medicine
https://www.readbyqxmd.com/read/27803789/prednison-provokes-serum-and-vasoactive-substances-in-a-mice-model-of-immune-thrombocytopenia
#19
Ling Zhang, Ke Chen, Tiantian Li, Hao He, Li Hou, Xiaoyong Wu, Yanping Sun, Lei Zheng, Zhixiong Chen, Bei Qin, Xinyi Chen, Shaodan Tian
OBJECTIVES: The main objective of this study was to investigate the variations of β-endorphin (β-EP), vasoactive intestinal peptide (VIP), serotonin (5-HT) and norepinephrine (NE) of immune thrombocytopenia (ITP) mice as well as the regulatory mechanism of prednison. MATERIALS AND METHODS: Sixty BALB/c mice were randomly divided into control group, model group and prednison intervention group. ITP mice model was duplicated by injecting with glycoprotein-antiplatelet serum (GP-APS) except in control group...
September 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27803506/role-of-novel-oral-anticoagulants-in-the-treatment-of-antiphospholipid-syndrome
#20
C Whitney White, Angela R Thomason, Katie Boyd
Background: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by thrombosis or pregnancy loss with persistent positive antibodies. Standard treatment for APS with history of thromboembolism is heparin or low-molecular-weight heparin followed by a vitamin K antagonist (VKA). Novel oral anticoagulants (NOACs) could be effective in patients with APS, but none carry indications for treatment related to APS. Clinical Evidence: Five case reports or series with rivaroxaban and dabigatran suggest thrombotic events occur most often in the higher risk population (arterial thrombosis and/or triple positive antibodies) or in patients who had recurrent VTEs on warfarin therapy...
October 2016: Hospital Pharmacy
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