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https://www.readbyqxmd.com/read/29904380/antiphospholipid-syndrome-nephropathy-from-pathogenesis-to-treatment
#1
REVIEW
Maria G Tektonidou
Kidney damage is a well-recognized complication of the antiphospholipid syndrome (APS), either primary or systemic lupus erythematosus (SLE)-associated APS. Kidney involvement in APS involves a variety of manifestations, such as renal artery thrombosis or stenosis, renal vein thrombosis, allograft loss due to thrombosis after kidney transplantation, and injury to the renal microvasculature, also known as APS nephropathy. Biopsy in patients with APS nephropathy includes acute thrombotic microangiopathy lesions and chronic intrarenal vascular lesions such as interlobular fibrous intimal hyperplasia, arterial and arteriolar recanalizing thrombosis, fibrous arterial occlusion, and focal cortical atrophy...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29895622/prothrombin-conversion-is-accelerated-in-the-antiphospholipid-syndrome-and-insensitive-to-thrombomodulin
#2
Romy M W Kremers, Stéphane Zuily, Hilde Kelchtermans, Tessa C Peters, Saartje Bloemen, Véronique Regnault, H Coenraad Hemker, Philip G de Groot, Denis Wahl, Bas de Laat
Antiphospholipid syndrome (APS) is a condition in which the presence of antibodies against phospholipid-binding proteins is associated with thrombophilia and/or pregnancy morbidity. Although antiphospholipid antibodies have anticoagulant characteristics in vitro, they are associated with thromboembolic complications. Thrombin generation (TG) is a sensitive global test of coagulation, and elevated TG is associated with thrombosis. Increased TG can be caused by increased prothrombin conversion, decreased thrombin inactivation, or a combination of both...
June 12, 2018: Blood Advances
https://www.readbyqxmd.com/read/29884138/the-complex-treatment-including-rituximab-in-the-management-of-catastrophic-antiphospholid-syndrome-with-renal-involvement
#3
Aleksandra Rymarz, Stanisław Niemczyk
BACKGROUND: Catastrophic antiphospholipid syndrome (CAPS) is a rare, life-threatening form of antiphospholipid syndrome (APS) involving many organs and leading to their insufficiency. The pathogenesis of CAPS is associated with the presence of antiphospholipid antibodies (aPL). Typical therapy includes anticoagulation, glucocorticoids, therapeutic plasma exchanges and/or intravenous immunoglobulin. Despite this aggressive treatment, the mortality rate of 37% is still high. Novel therapeutic agents are required...
June 8, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29883330/-systemic-lupus-erythematosus-and-antiphospholipid-syndrome-diagnostic-and-therapeutic-problems
#4
Zbigniew Zdrojewski
Recognizing the antiphospholipid syndrome (APS) in patients with lupus (SLE) can be difficult and therefore underestimated. Detection of antiphospholipid antibodies (aPL) in each patient with SLE should be done as a rule. Introduction of the new classification criteria of this syndrome will certainly improve the recognition of APS in the future. The Sapporo APS classification criteria (1998) were replaced by the Sydney criteria in 2006. Based on the most recent criteria, classification with APS requires one clinical and one laboratory manifestation...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29872283/pain-as-a-challenge-in-nursing-home-residents-with-behavioral-and-psychological-symptoms-of-dementia
#5
Tomasz Nowak, Agnieszka Neumann-Podczaska, Ewa Deskur-Śmielecka, Arkadiusz Styszyński, Katarzyna Wieczorowska-Tobis
Introduction: In patients with dementia, observational scales are recommended for use in the assessment of pain. Unfortunately, their application is rare, and as a consequence pain is frequently underdiagnosed and undertreated in these types of subjects. Thus, the aim of the study was to assess analgesic treatment in nursing home residents with cognitive impairment and to delineate the relationship between pain and behavioral and psychological symptoms of dementia. Patients and methods: The research was conducted in 2 nursing home facilities in Wielkopolska, Poland...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29861569/lupus-nephritis-with-coexistent-antiphospholipid-antibodies-associated-nephropathy-a-case-report-and-literature-review
#6
K Talari, U Anandh, A Patrick
Antiphospholipid syndrome (APS) associated nephropathy is a distinct clinical entity and can occur in patients with systemic lupus erythematosus (SLE) independent of or associated with lupus nephritis. Associated APS nephropathy in a patient with lupus predicts poor renal outcome, especially if left untreated. Recognizing a coexistent APS nephropathy in a patient with lupus nephritis is of utmost importance. Here, we present a patient with severe lupus nephritis with antiphospholipid antibodies (aPLs) who had no thrombotic manifestations of APS clinically...
March 2018: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29850957/thrombosis-and-anti-phospholipid-syndrome-a-5-year-update-on-treatment
#7
REVIEW
Cecilia Beatrice Chighizola, Pier Luigi Meroni
PURPOSE OF REVIEW: The aim of this review is to provide an update of the therapeutic tools for thrombotic anti-phospholipid syndrome (APS), focusing on the last 5 years. RECENT FINDINGS: Early studies appointed anticoagulation at moderate intensity as the mainstay of treatment of thrombotic APS; in the last 5 years, the strategy has not much mutated. Some uncertainties regarding the role of direct oral anticoagulants and the optimal regimen for arterial thrombotic APS still persist: high-intensity anticoagulation, anticoagulation plus anti-platelet agent, and double anti-platelet agents being the possible alternatives...
May 31, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29808136/clinical-report-of-probable-catastrophic-antiphospholipid-syndrome-in-pregnancy
#8
Eryk Hakman, Sasha Mikhael
Background: Catastrophic APS (CAPS) is a rare but life-threatening form of APS defined as multiorgan thrombosis affecting a minimum of three organs with confirmation by histopathology of small vessel occlusions in at least one organ or tissue. The development of CAPS in pregnancy poses many diagnostic challenges as a result of its broad range of clinical presentations and its overlap with other obstetric complications and microangiopathic diseases. Because of the high associated mortality rate, prompt recognition and treatment are paramount...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29801596/-as-needed-range-orders-for-opioid-analgesics-in-the-management-of-pain-a-consensus-statement-of-the-american-society-for-pain-management-nursing-and-the-american-pain-society
#9
Debra J Drew, Debra B Gordon, Bonnie Morgan, Renee C B Manworren
Effective pain management requires careful titration of analgesics and evaluation of individual patient's responses to treatment using valid and reliable pain and pain relief assessment tools, and evidence-based patient monitoring for adverse treatment effects. A registered nurse, competent in pain assessment and analgesic administration, can safely interpret and implement properly written ''as-needed'' or ''PRN'' range orders for analgesic medications. The American Society for Pain Management Nursing (ASPMN) and the American Pain Society (APS) support safe medication practices and the appropriate use of PRN range orders for opioid analgesics in the management of pain...
June 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29779963/action-potential-initiation-propagation-and-cortical-invasion-in-the-hyperdirect-pathway-during-subthalamic-deep-brain-stimulation
#10
Ross W Anderson, AmirAli Farokhniaee, Kabilar Gunalan, Bryan Howell, Cameron C McIntyre
BACKGROUND: High frequency (∼130 Hz) deep brain stimulation (DBS) of the subthalamic region is an established clinical therapy for the treatment of late stage Parkinson's disease (PD). Direct modulation of the hyperdirect pathway, defined as cortical layer V pyramidal neurons that send an axon collateral to the subthalamic nucleus (STN), has emerged as a possible component of the therapeutic mechanisms. However, numerous questions remain to be addressed on the basic biophysics of hyperdirect pathway stimulation...
May 12, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29770151/research-on-establishment-of-abnormal-phlegmatic-syndrome-with-premature-ovarian-failure-rat-model-and-effects-of-balgham-munziq-treatment
#11
Muladili Yuemaier, Mayire Tuerhong, Abulizi Keremu, Nafeisha Kadeer, Ayiguzhali Aimaiti, Xilinguli Wushouer, Adilijiang Yiming, Xiamixinuer Yilike
This study aimed to establish and explore the biological basis of abnormal phlegmatic syndrome with premature ovarian failure (POF) model in rats based on the Uighur medicine (UM) in the first place and investigate the effects of unique herbal medicine, Balgham Munziq (BMq). Mature female Wistar rats were fed with spinach and coriander in cold and humid condition for approximately 20 weeks until abnormal phlegmatic syndrome (APS) model was established. When APS model was confirmed by Uighur medical experts, APS with POF disease rats were subdivided into APS with POF disease model group and APS with POF disease treated with BMq group; the rest of them were subdivided into APS model group and APS treated with BMq group...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29768038/use-and-characteristics-of-antipsychotic-methylphenidate-combination-therapy-in-children-and-adolescents-with-a-diagnosis-of-attention-deficit-hyperactivity-disorder
#12
Oliver Scholle, Tobias Banaschewski, Dirk Enders, Edeltraut Garbe, Oliver Riedel
OBJECTIVE: Children and adolescents with attention-deficit/hyperactivity disorder (ADHD) frequently have comorbidities that are potential indications for antipsychotics (APs). Some studies have suggested that the combined use of methylphenidate (MPH) and APs is increasing in this population group. Longitudinal analyses and in-depth investigations on the substance level are lacking. This study aimed to estimate the cumulative proportion of concomitant AP/MPH use in children and adolescents with ADHD over a follow-up of up to 9 years and to describe patient characteristics stratified by specific AP drug...
May 16, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29767567/impact-of-ntrk2-drd2-and-ace-polymorphisms-on-prolactin-levels-in-antipsychotic-treated-patients-with-first-episode-psychosis
#13
Patricia Gassó, Sergi Mas, Miquel Bioque, Bibiana Cabrera, Antonio Lobo, Ana González-Pinto, Covadonga M Díaz-Caneja, Iluminada Corripio, Eduard Vieta, Josefina Castro-Fornieles, Salvador Sarró, Anna Mané, Julio Sanjuan, Adrián Llerena, Amalia Lafuente, Jerónimo Saiz-Ruiz, Miguel Bernardo
BACKGROUND: Hyperprolactinemia is a common side-effect of antipsychotics (APs), which may trigger serious secondary problems and compromise the adherence to treatment which is crucial for prognosis, especially in patients presenting with a first-episode of psychosis (FEP). AIMS: We evaluated, in some cases for the first time, the effect of polymorphisms in multiple candidate genes on serum prolactin (PRL) levels in an AP-treated FEP cohort recruited in the multicenter PEPs study (Phenotype - genotype and environmental interaction; Application of a predictive model in first psychotic episodes)...
May 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29767138/effects-of-essential-oils-on-performance-egg-quality-nutrient-digestibility-and-yolk-fatty-acid-profile-in-laying-hens
#14
Xuemei Ding, Yang Yu, Zhuowei Su, Keying Zhang
The study was conducted to investigate the effect of essential oils on performance, egg quality, nutrient digestibility and yolk fatty acid profile in laying hens. A total of 960 Lohmann laying hens aged 53 weeks were enrolled, under 4 different treatment diets supplemented with 0, 50, 100 and 150 mg/kg essential oils (Enviva EO, Dupont Nutrition Biosciences ApS, Denmark), respectively. Each treatment was replicated 8 times with 30 birds each. Birds were fed dietary treatment diets for 12 weeks (54 to 65 weeks)...
June 2017: Animal nutrition
https://www.readbyqxmd.com/read/29766600/effect-of-childhood-adversities-on-alcohol-problems-is-mainly-mediated-by-depression
#15
Raimo K R Salokangas, Tiina From, Sinikka Luutonen, Henri R W Salokangas, Jarmo Hietala
BACKGROUND AND OBJECTIVES: We aimed to study how five childhood adversities and trauma (CAT) core domains: emotional abuse (EmoAb), physical abuse (PhyAb), sexual abuse (SexAb), emotional neglect (EmoNeg), physical neglect (PhyNeg), associate with alcohol problems (APs), and whether there are any gender differences in these associations. METHODS: Altogether, 690 adult participants drawn from the general population completed a mailed questionnaire, including the trauma and distress scale, as an indicator of CAT, and questions concerning sociodemographic background, depressive symptoms, and APs...
May 15, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29765084/hepatoprotective-effects-of-auricularia-cornea-var-li-polysaccharides-against-the-alcoholic-liver-diseases-through-different-metabolic-pathways
#16
Xiuxiu Wang, Yufei Lan, Yongfa Zhu, Shangshang Li, Min Liu, Xinling Song, Huajie Zhao, Weiru Liu, Jianjun Zhang, Shouxian Wang, Le Jia
The present work was designed to evaluate the antioxidation and hepatoprotective effects of Auricularia cornea var. Li. polysaccharides (APS) and enzymatic-extractable APS (EAPS) on the acute alcohol-induced alcoholic liver diseases (ALD). The in vitro antioxidant activities demonstrated that both APS and EAPS had strong reducing power and potential effects on scavenging reactive oxygen species. The in vivo mice experiments showed that the pretreatment with APS or EAPS showed potential hepatoprotective effects on the ALD possibly by increasing the antioxidant activities, reducing the lipid peroxidation, improving the alcohol metabolism, inhibiting the expression levels of inflammatory mediators and preventing the alcohol-induced histopathological alterations...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29755633/coronary-artery-thromboses-stent-thrombosis-and-antiphospholipid-antibody-syndrome-case-report
#17
Augusto Ferreira Correia, Dinaldo Cavalcanti Oliveira, Marcio Sanctos
The antiphospholipid antibody syndrome (APS) is defined by a state of hypercoagulability secondary to an autoimmune disorder. There are evidences that approximately 2.8-5.5% of cases of acute myocardial infarction (AMI) in young individuals are secondary to APS. In this case report, three coronary artery thromboses occurring within a short period are described. Initially, there was an ST-segment elevation (STEMI) in the presence of coronary artery disease (CAD), with the vessel being treated with stent implantation...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29755341/plasma-biomarkers-differentiate-parkinson-s-disease-from-atypical-parkinsonism-syndromes
#18
Chin-Hsien Lin, Shieh-Yueh Yang, Herng-Er Horng, Che-Chuan Yang, Jen-Jie Chieh, Hsin-Hsien Chen, Bing-Hsien Liu, Ming-Jang Chiu
Objective: Parkinson's disease (PD) has significant clinical overlaps with atypical parkinsonism syndromes (APS), which have a poorer treatment response and a more aggressive course than PD. We aimed to identify plasma biomarkers to differentiate PD from APS. Methods: Plasma samples ( n = 204) were obtained from healthy controls and from patients with PD, dementia with Lewy bodies (DLB), multiple system atrophy, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), or frontotemporal dementia (FTD) with parkinsonism (FTD-P) or without parkinsonism...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29748101/results-from-the-study-to-assess-outcomes-after-endovascular-repair-for-multiple-thoracic-aortic-diseases-summit
#19
Nikolaos Tsilimparis, Sebastian Debus, Min Chen, Qing Zhou, Mary-Margaret Seale, Tilo Kölbel
OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) is currently the treatment of choice for most diseases of the descending thoracic aorta. Using data from the Study to Assess Outcomes After Endovascular Repair for Multiple Thoracic Aortic Diseases (SUMMIT) study we investigated the outcomes of TEVAR for different aortic diseases and risk factors associated with the outcomes. METHODS: The SUMMIT study included aggregated data of 521 TEVAR patients from five Cook-sponsored multicenter trials evaluating thoracic endografts of the Zenith platform (William Cook Europe, ApS, Bjaeverskov, Denmark)...
May 7, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29730854/renal-involvement-in-antiphospholipid-syndrome
#20
REVIEW
Francisco Vileimar Andrade de Azevedo, Diego Germano Maia, Jozelio Freire de Carvalho, Carlos Ewerton Maia Rodrigues
This is a review of scientific publications on renal involvement in antiphospholipid syndrome (APS), with focus on clinical and histopathological findings and treatment. A search for English-language articles on renal involvement in APS covering the period 1980-2017 was conducted in Medline/PubMed and Scopus databases using the MeSH terms "antiphospholipid syndrome", "antiphospholipid antibodies", "glomerulonephritis" and "thrombotic microangiopathy" (TMA). APS nephropathy is primarily the result of thromboses in renal arteries or veins, intraparenchymatous arteries and glomerular capillaries...
May 5, 2018: Rheumatology International
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