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Vertebral maturation index

Hafiz Taha Mahmood, Attiya Shaikh, Mubassar Fida
INTRODUCTION: Various methods have been proposed to evaluate a patient's developmental status. However, most of them lacked precision and failed to give a reliable estimate of skeletal maturity. The aims of this study were to evaluate the association between frontal sinus morphology and cervical vertebral maturation for the assessment of skeletal maturity and to determine its validity in assessing the different stages of the adolescent growth spurt. METHODS: A cross-sectional study was performed on the pretreatment lateral cephalograms of 252 subjects aged 8 to 21 years...
October 2016: American Journal of Orthodontics and Dentofacial Orthopedics
Elizabeth A DuPlessis, Eustaquio A Araujo, Rolf G Behrents, Ki Beom Kim
INTRODUCTION: The purpose of this investigation was to determine whether a relationship exists between body mass and dental and skeletal development in children and adolescents. A sample of 197 orthodontic patients (82 boys, 115 girls) was selected. Ethnicity was recorded, and body mass index (BMI) was calculated according to the standard equation from the Centers for Disease Control and Prevention, and then a BMI percentile according to sex and age was obtained. The panoramic radiographs were used to calculate the dental ages with an index...
August 2016: American Journal of Orthodontics and Dentofacial Orthopedics
G Cossellu, G Farronato, O Nicotera, R Biagi
AIM: The aim of this study is to evaluate whether a transverse maxillary deficit can cause an alteration of vertebral development and therefore of the skeletal maturation comparing the cervical maturation stages index with the hand-wrist index. MATERIALS AND METHODS: For the study were selected 200 patients aged 7-14 years, equally distributed by gender and divided into 100 study subjects with maxillary deficit and 100 controls without maxillary deficit. The skeletal maturation index (SM according to Fishman) was evaluated and compared with the hand-wrist x-rays and the cervical vertebrae maturation (CVM according to Hassel and Farmann)...
June 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
Jamal Giri, Basanta Kumar Shrestha, Rajiv Yadav, Tika Ram Ghimire
BACKGROUND: Assessment of growth status of a patient is a key component in orthodontic diagnosis and treatment planning for growing patients with skeletal discrepancy. Skeletal maturation based on hand-wrist radiograph and cervical vertebral maturation (CVM) are commonly used methods of growth assessment. Studies have shown that stages of dental calcification can also be used to assess skeletal maturation status of an individual, whereas other studies have suggested that the relationship between dental calcification and skeletal maturation should be interpreted with caution owing to racial variation...
2016: Clinical, Cosmetic and Investigational Dentistry
Maria Antonietta Isgrò, Patrizia Bottoni, Roberto Scatena
Neuron-specific enolase (NSE) is known to be a cell specific isoenzyme of the glycolytic enzyme enolase. In vertebrate organisms three isozymes of enolase, expressed by different genes, are present: enolase α is ubiquitous; enolase β is muscle-specific and enolase γ is neuron-specific. The expression of NSE, which occurs as γγ- and αγ-dimer, is a late event in neural differentiation, thus making it a useful index of neural maturation.NSE is a highly specific marker for neurons and peripheral neuroendocrine cells...
2015: Advances in Experimental Medicine and Biology
Krzysztof Dudek, Piotr Skórka, Zofia Anna Sajkowska, Anna Ekner-Grzyb, Monika Dudek, Piotr Tryjanowski
The success of ectoparasites depends primarily on the site of attachment and body condition of their hosts. Ticks usually tend to aggregate on vertebrate hosts in specific areas, but the distribution pattern may depend on host body size and condition, sex, life stage or skin morphology. Here, we studied the distribution of ticks on lizards and tested the following hypothesis: occurrence or high abundance of ticks is confined with body parts with smaller scales and larger interscalar length because such sites should provide ticks with superior attachment conditions...
February 2016: Ticks and Tick-borne Diseases
Liana Tascau, Thomas Gardner, Hussein Anan, Charlie Yongpravat, Christopher P Cardozo, William A Bauman, Francis Y Lee, Daniel S Oh, Hesham A Tawfeek
Protein kinase A (PKA) regulates osteoblast cell function in vitro and is activated by important bone mass modulating agents. We determined whether PKA activation in osteoblasts is sufficient to mediate a bone anabolic response. Thus, a mouse model conditionally expressing a constitutively active PKA (CA-PKA) in osteoblasts (CA-PKA-OB mouse) was developed by crossing a 2.3-kb α1 (I)-collagen promoter-Cre mouse with a floxed-CA-PKA mouse. Primary osteoblasts from the CA-PKA-OB mice exhibited higher basal PKA activity than those from control mice...
January 2016: Endocrinology
Mitsuru Saito, Yoshikuni Kida, Tetsuro Nishizawa, Shotaro Arakawa, Hinako Okabe, Azusa Seki, Keishi Marumo
Bazedoxifene (BZA) is used for the treatment of post-menopausal osteoporosis. To elucidate changes in collagen, mineralization, and structural properties and their relationship to bone strength after treatment with BZA in ovariectomized (OVX) monkeys, the levels of collagen and enzymatic immature, mature, and non-enzymatic cross-links were simultaneously examined, as well as trabecular architecture and mineralization of vertebrae. Adult female cynomolgus monkeys were divided into 4 groups (n=18 each) as follows: Sham group, OVX group, and OVX monkeys given either 0...
December 2015: Bone
Kiran Ghodke, Tanuja Shet, Sridhar Epari, Manju Sengar, Hari Menon, Sumeet Gujral
Plasmacytoma classified into solitary plasmacytoma of bone (SPB) and extramedullary plasmacytoma (EMP) is characterized by infiltrate of plasma cells of diverse maturity and by their monoclonal immunoglobulin products. Both SPB and EMP represent different groups of neoplasm in terms of location, tumor progression, and overall survival rate. There is a need for features that indicate likelihood of myeloma in patients with plasmacytoma without other manifestations. This study was an attempt to study the morphologic patterns of plasmacytoma (SPB and EMP), MIB1 proliferation index, and correlation of these with clinicopathologic features and survival of the patients...
June 2015: Annals of Diagnostic Pathology
Sandra Leibold, Matthias Hammerschmidt
In recent years, the zebrafish (Danio rerio) has emerged as an alternative vertebrate model for energy homeostasis and metabolic diseases, including obesity and anorexia. It has been shown that diet-induced obesity (DIO) in zebrafish shares multiple pathophysiological features with obesity in mammals. However, a systematic and comprehensive analysis of the different pathways of energy expenditure in obese and starved fish had been missing thus far. Here, we carry out long-term ad libitum feeding (hyperphagia) and caloric restriction studies induced by low- or high-density husbandry, respectively, to investigate the impact of caloric intake on the timing of scale formation, a crucial step of postembryonic development and metamorphosis, and on somatic growth, body weight, fat storage and female reproduction...
2015: PloS One
Eric Londin, Phillipe Loher, Aristeidis G Telonis, Kevin Quann, Peter Clark, Yi Jing, Eleftheria Hatzimichael, Yohei Kirino, Shozo Honda, Michelle Lally, Bharat Ramratnam, Clay E S Comstock, Karen E Knudsen, Leonard Gomella, George L Spaeth, Lisa Hark, L Jay Katz, Agnieszka Witkiewicz, Abdolmohamad Rostami, Sergio A Jimenez, Michael A Hollingsworth, Jen Jen Yeh, Chad A Shaw, Steven E McKenzie, Paul Bray, Peter T Nelson, Simona Zupo, Katrien Van Roosbroeck, Michael J Keating, George A Calin, Charles Yeo, Masaya Jimbo, Joseph Cozzitorto, Jonathan R Brody, Kathleen Delgrosso, John S Mattick, Paolo Fortina, Isidore Rigoutsos
Two decades after the discovery of the first animal microRNA (miRNA), the number of miRNAs in animal genomes remains a vexing question. Here, we report findings from analyzing 1,323 short RNA sequencing samples (RNA-seq) from 13 different human tissue types. Using stringent thresholding criteria, we identified 3,707 statistically significant novel mature miRNAs at a false discovery rate of ≤ 0.05 arising from 3,494 novel precursors; 91.5% of these novel miRNAs were identified independently in 10 or more of the processed samples...
March 10, 2015: Proceedings of the National Academy of Sciences of the United States of America
Christos Karampalis, Nikolaos Bounakis, Athanasios I Tsirikos
INTRODUCTION: Treacher Collins syndrome is an autosomal dominant disorder resulting in congenital craniofacial deformities. Scoliosis has not been previously reported as one of the extracranial manifestations of this syndromic condition. CASE PRESENTATION: We present a 15-year-old British Caucasian girl with Treacher Collins syndrome who developed a severe double thoracic scoliosis measuring 102° and 63° respectively. The deformity was noted at age 14 years by the local general practitioner and gradually progressed until she was referred to our service and subsequently was scheduled for surgical correction...
2014: Journal of Medical Case Reports
G O Cericato, M A V Bittencourt, L R Paranhos
OBJECTIVES: To perform a systematic review with meta-analysis to answer the question: is the cervical vertebrae maturation index (CVMI) effective to replace hand-wrist radiograph (gold standard) in determining the pubertal growth spurt in patients undergoing bone growth? METHODS: A search in three databases was performed, in which studies were selected that compared one of the two main assessment methods for cervical vertebrae (Hassel B, Farman AG. Skeletal maturation evaluation using cervical vertebrae...
2015: Dento Maxillo Facial Radiology
Zohreh Hedayati, Fatemeh Khalafinejad
STATEMENT OF THE PROBLEM: The prevalence of overweight and obesity has been increasing markedly in recent years. It may influence growth in pre pubertal children. PURPOSE: The purpose of this study was to determine whether increased Body Mass Index (BMI) is associated with accelerated skeletal maturation and dental maturation in six to fifteen years old orthodontic patients in Shiraz, Iran. MATERIALS AND METHOD: Skeletal maturation and dental development of 95 orthodontic patients (65 females and 30 males), aged 6 to 15 years, were determined...
December 2014: Journal of Dentistry
S M Shin, Y-I Kim, Y-S Choi, T Yamaguchi, K Maki, B-H Cho, S-B Park
OBJECTIVES: To evaluate axial cervical vertebral (ACV) shape quantitatively and to build a prediction model for skeletal maturation level using statistical shape analysis for Japanese individuals. METHODS: The sample included 24 female and 19 male patients with hand-wrist radiographs and CBCT images. Through generalized Procrustes analysis and principal components (PCs) analysis, the meaningful PCs were extracted from each ACV shape and analysed for the estimation regression model...
2015: Dento Maxillo Facial Radiology
Saravanan Pichai, M Rajesh, Naveen Reddy, Gopinath Adusumilli, Jayaprakash Reddy, Bhavana Joshi
BACKGROUND: Skeletal maturation is an integral part of individual pattern of growth and development and is a continuous process. Peak growth velocity in standing height is the most valid representation of the rate of overall skeletal growth. Ossification changes of hand wrist and cervical vertebrae are the reliable indicators of growth status of individual. The objective of this study was to compare skeletal maturation as measured by hand wrist bone analysis and cervical vertebral analysis...
September 2014: Journal of International Oral Health: JIOH
N T Hua, H Ako
Gonadotropin releasing hormone (GnRH) is a neuropeptide hormone whic plays an important role in control of the reproduction among vertebrates and some work is showing that it is active in invertebrate species. We matured and spawned the Hawaiian opihi Cellana spp. by using salmon GnRH analogue. In the first experiment on maturation, twelve adult opihi (3.18+/-0.23cm, shell length) were injected weekly with salmon GnRHa at dose of 250ng.g-1 body weight (BW) for a 6-week period. Gonad development was assessed using gonadosomatic index (GSI) and histological techniques...
2013: Communications in Agricultural and Applied Biological Sciences
Athina Lani, Nikolaos Kourkoumelis, Gerasimos Baliouskas, Margaret Tzaphlidou
Fourier transform infrared spectroscopy is utilized to examine the effects of increased calcium, vitamin D, and combined calcium-vitamin D supplementation on osteoporotic rabbit bones with induced inflammation. The study includes different bone sites (femur, tibia, humerus, vertebral rib) in an effort to explore possible differences among the sites. We evaluate the following parameters: mineral-to-matrix ratio, carbonate content, and non-apatitic species (labile acid phosphate and labile carbonate) contribution to bone mineral...
September 2014: Journal of Biological Physics
Francesca Silvestrini-Biavati, Alessandro Ugolini, Nicola Laffi, Carola Canevello, Armando Silvestrini-Biavati
AIMS: The aim of this research was to complete Habets's method on orthopantomogram, in order to measure mandibular symmetry horizontally and diagonally in mixed dentition as the first diagnostic evaluation. SETTINGS AND DESIGN: Mixed dentition subjects were consecutively selected according to skeletal maturity. MATERIALS AND METHODS: Inclusion criteria were: Mixed dentition, cervical vertebral stages 1-2, Class II or Class III malocclusions, with or without unilateral posterior cross-bite...
March 2014: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
Diana M Papoulias, Donald E Tillitt, Melaniya G Talykina, Jeffrey J Whyte, Catherine A Richter
Atrazine is an effective broadleaf herbicide and the second most heavily used herbicide in the United States. Effects along the hypothalamus-pituitary-gonad axis in a number of vertebrate taxa have been demonstrated. Seasonally elevated concentrations of atrazine in surface waters may adversely affect fishes, but only a few studies have examined reproductive effects of this chemical. The present study was designed to evaluate a population endpoint (egg production) in conjunction with histological (reproductive stage, gonad pathology) and biochemical (aromatase activity, sex hormone production) phenotypes associated with atrazine exposure in Japanese medaka...
September 2014: Aquatic Toxicology
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