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Vertebral maturation index

Masayuki Ohashi, Kei Watanabe, Toru Hirano, Kazuhiro Hasegawa, Keiichi Katsumi, Hirokazu Shoji, Mizouchi Tatsuki, Naoto Endo
STUDY DESIGN: A retrospective, long-term follow-up study. OBJECTIVE: We aimed to clarify the predicting factors at skeletal maturity for future curve progression and low back pain (LBP) in adolescent idiopathic scoliosis (AIS) with thoracolumbar/lumbar (TL/L) curve. SUMMARY OF BACKGROUND DATA: TL/L curves are likely to progress after skeletal maturity and cause LBP. METHODS: Of 147 patients treated non-operatively for AIS with TL/L curve, 56 (55 females; average age at the time of survey, 39...
May 10, 2018: Spine
Tulika Tripathi, Prateek Gupta, Jitender Sharma, Priyank Rai, Vinod Kumar Gupta, Navneet Singh
OBJECTIVE: The present study was aimed to assess levels of serum Bone-specific alkaline phosphatase (BALP) and serum Insulin-like growth factor-1 (IGF-1) and comparing with cervical vertebral maturation index (CVMI) stages. DESIGN: Cross-sectional study. SETTING: Maulana Azad Institute of Dental Sciences, New Delhi, India. PARTICIPANTS: 150 subjects (75 males and 75 females) in the age group of 8-20 years. METHODS: Subjects were divided into six CVMI stages...
March 2018: Journal of Orthodontics
Lian Hollander-Cohen, Matan Golan, Joseph Aizen, Michal Shpilman, Berta Levavi-Sivan
Two gonadotropins, follicle stimulating hormone (FSH) and luteinizing hormone (LH), are important players in the hypothalamic-pituitary-gonadal axis of vertebrates. In the present work, we describe the construction of recombinant (r) common carp (Cyprinus carpio; c) FSH (rcFSH) and LH (rcLH) using the Pichia pastoris system, the generation of specific antibodies against their respective β subunits, and their use in the development and validation of specific ELISAs. We produced carp rLH and rFSH as single-chain polypeptides, wherein the GTH subunit α was joined with either cLHβ or cFSHβ mature protein-coding sequences to form a fusion gene that encodes a yoked polypeptide, in which the GTH β-subunit forms the N-terminal part and the α-subunit forms the C-terminal part...
November 26, 2017: General and Comparative Endocrinology
Tulika Tripathi, Prateek Gupta, Priyank Rai, Jitender Sharma, Vinod Kumar Gupta, Navneet Singh
BACKGROUND: With change in concepts of growth determination methods, there is a surge in the measurement of biomarkers for appraisal of growth status. Osteocalcin is a bone-specific protein and was observed to parallel the normal growth curve. Hence, the present study was intended to assess the levels of serum osteocalcin and serum insulin-like growth factor-1 (IGF-1) and compare them with cervical vertebral maturation index (CVMI) stages. METHODS: The cross-sectional study was performed on 150 subjects (75 males and 75 females) in the age group of 8-20 years and segregated into six CVMI stages...
October 2, 2017: Progress in Orthodontics
Saibin Wang, Qian Ye, Junwei Tu, Mingying Zhang, Bin Ji
The pathogenesis of visual dysfunction in stroke remains unclear. The objective of this study was to explore retinal damage in stroke spontaneously hypertensive rats (SHR) and evaluate the role of curcumin in the retinal injury after stroke. Mature male SHR were used as the animal model for hypertension and age-matched male Wistar-Kyoto (WKY) rats as the normotensive controls. The rat model of stroke was made by bilateral vertebral artery electrocoagulation combined with transient bilateral common carotid artery ligation...
July 5, 2017: Clinical and Experimental Hypertension: CHE
V I Tsymbalyuk, V V Medvedyev, V M Semenova, N Ya Grydina, Yu Ya Yaminskyi, Yu Yu Senchyk, N G Draguntsova, O A Rybachuk, S M Dychko, T I Petriv
Simulation model of open penetrating wound of a spinal cord (SC) with its durable com- pression by biocompatible foreign body, was tasted. Experimental animals - mature male rats (inbred line, descendent from a Wistar breed); the trauma simulation model - a left- sided transsection of the SC half on the Txi level; experimental groups: the main (a SC trau- ma + homotopic implantation of microporous hydrogel fragment - foreign body [n=10]), groups of comparison (the SC trauma [n=16]; the SC trauma + homotopic implantation of chemically identical analogue of hydrogel - NeuroGelTM [n=20])...
August 2016: Klinichna Khirurhiia
John T Wilkinson, Chad E Songy, David B Bumpass, Francis L McCullough, Richard E McCarthy
BACKGROUND: The Shilla procedure was designed to correct and control early-onset spinal deformity while harnessing a child's remaining spinal growth. It allows for controlled axial skeletal growth within the construct, avoiding the need for frequent surgeries to lengthen implants. We hypothesized that curve characteristics evolve over time after initial apex fusion and placement of the Shilla implants. The purpose of this study was to identify trends in curve evolution after Shilla implantation and understand how these changes influence ultimate outcome...
April 3, 2017: Journal of Pediatric Orthopedics
Vildana Džemidžić, Alisa Tiro, Amila Zukanović, Ismeta Redžić, Enita Nakaš
OBJECTIVE: The aims of this study were: to investigate the relationship between mandibular canine calcification stages and skeletal maturity; and to evaluate whether the mandibular canine calcification stages may be used as a reliable diagnostic tool for skeletal maturity assessment. MATERIALS AND METHODS: This study included 151 subjects: 81 females and 70 males, with ages ranging from 9 to 16 years (mean age: 12.29±1.86 years). The inclusion criteria for subjects were as follows: age between 9 and 16 years; good general health without any hormonal, nutritional, growth or dental development problems...
November 2016: Acta Medica Academica
A Bellodi, C Porcu, R Cannas, Al Cau, M F Marongiu, A Mulas, S Vittori, M C Follesa
This work investigates life-history traits of the long-nosed skate Dipturus oxyrinchus, which is a common by-catch in Sardinian waters. The reproductive variables were analysed from 979 specimens sampled during scientific and commercial hauls. Females (10·4-117·5 cm total length, LT ) attained larger sizes than males (14·5-99·5 cm LT ). To evaluate age and growth, a sub-sample of 130 individuals (76 females and 54 males) were used. The age was estimated by annuli counts of sectioned vertebral centra...
March 2017: Journal of Fish Biology
Siamak Hemmatpour, Ali Mokhtar, Vahid Rakhshan
OBJECTIVE: The aim of this study was to evaluate the therapeutic effects of the Sabbagh Universal Spring 2 (SUS 2) fixed functional appliance compared to the premolar extraction method in correcting class II/1 malocclusion in patients who had passed their peak of postpubertal growth (stages 4-6 of Cervical Vertebral Maturation Index). METHODS: In all, 40 class II/1 patients were randomized to receive SUS 2 application (7 males, 13 females, age 15.75 ± 1.02 years) or maxillary premolar extraction (8 males, 12 females, age 15...
January 2017: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
Mohammadhashem Hoseini, Sara Zamaheni, Hourieh Bashizadeh Fakhar, Forough Akbari, Javad Chalipa, Afsaneh Rahmati
BACKGROUND: Prediction of skeletal growth is necessary for growth modification and surgical orthodontic treatments and is usually done by assessing skeletal maturity indicators in hand-wrist radiographs. The use of growth stages of cervical vertebrae in lateral cephalograms has been suggested to avoid overexposure. OBJECTIVES: This study seeks to assess the degree of agreement between hand-wrist and cervical vertebrae maturation stages for skeletal age determination and prediction of the peak growth spurt (PGS)...
July 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
Hafiz Taha Mahmood, Attiya Shaikh, Mubassar Fida
INTRODUCTION: Various methods have been proposed to evaluate a patient's developmental status. However, most of them lacked precision and failed to give a reliable estimate of skeletal maturity. The aims of this study were to evaluate the association between frontal sinus morphology and cervical vertebral maturation for the assessment of skeletal maturity and to determine its validity in assessing the different stages of the adolescent growth spurt. METHODS: A cross-sectional study was performed on the pretreatment lateral cephalograms of 252 subjects aged 8 to 21 years...
October 2016: American Journal of Orthodontics and Dentofacial Orthopedics
Elizabeth A DuPlessis, Eustaquio A Araujo, Rolf G Behrents, Ki Beom Kim
INTRODUCTION: The purpose of this investigation was to determine whether a relationship exists between body mass and dental and skeletal development in children and adolescents. A sample of 197 orthodontic patients (82 boys, 115 girls) was selected. Ethnicity was recorded, and body mass index (BMI) was calculated according to the standard equation from the Centers for Disease Control and Prevention, and then a BMI percentile according to sex and age was obtained. The panoramic radiographs were used to calculate the dental ages with an index...
August 2016: American Journal of Orthodontics and Dentofacial Orthopedics
G Cossellu, G Farronato, O Nicotera, R Biagi
AIM: The aim of this study is to evaluate whether a transverse maxillary deficit can cause an alteration of vertebral development and therefore of the skeletal maturation comparing the cervical maturation stages index with the hand-wrist index. MATERIALS AND METHODS: For the study were selected 200 patients aged 7-14 years, equally distributed by gender and divided into 100 study subjects with maxillary deficit and 100 controls without maxillary deficit. The skeletal maturation index (SM according to Fishman) was evaluated and compared with the hand-wrist x-rays and the cervical vertebrae maturation (CVM according to Hassel and Farmann)...
June 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
Jamal Giri, Basanta Kumar Shrestha, Rajiv Yadav, Tika Ram Ghimire
BACKGROUND: Assessment of growth status of a patient is a key component in orthodontic diagnosis and treatment planning for growing patients with skeletal discrepancy. Skeletal maturation based on hand-wrist radiograph and cervical vertebral maturation (CVM) are commonly used methods of growth assessment. Studies have shown that stages of dental calcification can also be used to assess skeletal maturation status of an individual, whereas other studies have suggested that the relationship between dental calcification and skeletal maturation should be interpreted with caution owing to racial variation...
2016: Clinical, Cosmetic and Investigational Dentistry
Maria Antonietta Isgrò, Patrizia Bottoni, Roberto Scatena
Neuron-specific enolase (NSE) is known to be a cell specific isoenzyme of the glycolytic enzyme enolase. In vertebrate organisms three isozymes of enolase, expressed by different genes, are present: enolase α is ubiquitous; enolase β is muscle-specific and enolase γ is neuron-specific. The expression of NSE, which occurs as γγ- and αγ-dimer, is a late event in neural differentiation, thus making it a useful index of neural maturation.NSE is a highly specific marker for neurons and peripheral neuroendocrine cells...
2015: Advances in Experimental Medicine and Biology
Krzysztof Dudek, Piotr Skórka, Zofia Anna Sajkowska, Anna Ekner-Grzyb, Monika Dudek, Piotr Tryjanowski
The success of ectoparasites depends primarily on the site of attachment and body condition of their hosts. Ticks usually tend to aggregate on vertebrate hosts in specific areas, but the distribution pattern may depend on host body size and condition, sex, life stage or skin morphology. Here, we studied the distribution of ticks on lizards and tested the following hypothesis: occurrence or high abundance of ticks is confined with body parts with smaller scales and larger interscalar length because such sites should provide ticks with superior attachment conditions...
February 2016: Ticks and Tick-borne Diseases
Liana Tascau, Thomas Gardner, Hussein Anan, Charlie Yongpravat, Christopher P Cardozo, William A Bauman, Francis Y Lee, Daniel S Oh, Hesham A Tawfeek
Protein kinase A (PKA) regulates osteoblast cell function in vitro and is activated by important bone mass modulating agents. We determined whether PKA activation in osteoblasts is sufficient to mediate a bone anabolic response. Thus, a mouse model conditionally expressing a constitutively active PKA (CA-PKA) in osteoblasts (CA-PKA-OB mouse) was developed by crossing a 2.3-kb α1 (I)-collagen promoter-Cre mouse with a floxed-CA-PKA mouse. Primary osteoblasts from the CA-PKA-OB mice exhibited higher basal PKA activity than those from control mice...
January 2016: Endocrinology
Mitsuru Saito, Yoshikuni Kida, Tetsuro Nishizawa, Shotaro Arakawa, Hinako Okabe, Azusa Seki, Keishi Marumo
Bazedoxifene (BZA) is used for the treatment of post-menopausal osteoporosis. To elucidate changes in collagen, mineralization, and structural properties and their relationship to bone strength after treatment with BZA in ovariectomized (OVX) monkeys, the levels of collagen and enzymatic immature, mature, and non-enzymatic cross-links were simultaneously examined, as well as trabecular architecture and mineralization of vertebrae. Adult female cynomolgus monkeys were divided into 4 groups (n=18 each) as follows: Sham group, OVX group, and OVX monkeys given either 0...
December 2015: Bone
Kiran Ghodke, Tanuja Shet, Sridhar Epari, Manju Sengar, Hari Menon, Sumeet Gujral
Plasmacytoma classified into solitary plasmacytoma of bone (SPB) and extramedullary plasmacytoma (EMP) is characterized by infiltrate of plasma cells of diverse maturity and by their monoclonal immunoglobulin products. Both SPB and EMP represent different groups of neoplasm in terms of location, tumor progression, and overall survival rate. There is a need for features that indicate likelihood of myeloma in patients with plasmacytoma without other manifestations. This study was an attempt to study the morphologic patterns of plasmacytoma (SPB and EMP), MIB1 proliferation index, and correlation of these with clinicopathologic features and survival of the patients...
June 2015: Annals of Diagnostic Pathology
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