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https://www.readbyqxmd.com/read/27872119/efficacy-of-intravenous-nicorandil-for-fractional-flow-reserve-assessment-study-protocol-for-a-crossover-randomised-trial
#1
Takeshi Nishi, Hideki Kitahara, Yoshihide Fujimoto, Takashi Nakayama, Kazumasa Sugimoto, Kengo Nagashima, Hideki Hanaoka, Yoshio Kobayashi
INTRODUCTION: Nicorandil has vasodilatory effects on both the epicardial coronary arteries and the coronary microvasculature, thereby increasing coronary blood flow. Intravenous administration of nicorandil can be applicable for fractional flow reserve (FFR) measurement as a hyperaemic agent and a possible alternative to adenosine. However, the effectiveness of intravenous nicorandil infusion for FFR measurement is largely unclear. METHODS AND ANALYSIS: This crossover randomised study is being performed to investigate the efficacy of intravenous administration of nicorandil for FFR measurement...
November 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27815334/effect-of-long-term-administration-of-nicorandil-on-endothelial-function-of-the-radial-artery-in-patients-with-angina-undergoing-transradial-percutaneous-coronary-intervention
#2
Yanming Fan, Xianghua Fu, Yanbo Wang, Wei Li, Xile Bi, Liye Wei, Yuyang Xiao, Shiru Bai
We evaluated the effect of long-term administration of nicorandil on endothelial function of the radial artery in patients with angina undergoing elective transradial coronary intervention (TRI). A total of 127 patients were randomly assigned to nicorandil (standard medication plus nicorandil 5 mg twice daily, n = 64) or control group (standard medication except nicorandil, n = 63) immediately after TRI procedure. Radial artery diameter (RAD), flow-mediated dilation (FMD), and nitroglycerin-mediated dilation (NMD) of radial artery were measured 1 day before TRI as well as 1 day and 3 months after TRI by Ultrasound-Doppler...
November 4, 2016: Angiology
https://www.readbyqxmd.com/read/27815172/nicorandil-inhibits-osteoclast-differentiation-in-vitro
#3
Futoshi Iwaki, Hitoshi Amano, Kiyoshi Ohura
Nicorandil is a hybrid angina therapeutic agent that has nitric oxide (NO) action and the ability to open ATP-sensitive K(+) channels (KATP channels). A transient increase in NO and intracellular Ca(2+) has been demonstrated to be highly involved in the differentiation and activation of osteoclasts. The objective of this study was to verify that the pharmacological effect of nicorandil suppresses the differentiation process of osteoclasts in vitro. Although little authentic NO production was detected in the culture medium in osteoclast formation assays, NO production increased only in the presence of nicorandil...
December 15, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27784845/potassium-channelopathies-and-gastrointestinal-ulceration
#4
REVIEW
Jaeyong Han, Seung Hun Lee, Gerhard Giebisch, Tong Wang
Potassium channels and transporters maintain potassium homeostasis and play significant roles in several different biological actions via potassium ion regulation. In previous decades, the key revelations that potassium channels and transporters are involved in the production of gastric acid and the regulation of secretion in the stomach have been recognized. Drugs used to treat peptic ulceration are often potassium transporter inhibitors. It has also been reported that potassium channels are involved in ulcerative colitis...
November 15, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27753906/os-02-06-physiological-regulation-of-vasomotion-by-intracellular-atp-mediated-system-in-human-artery
#5
Young Chul Kim, Dae Hoon Kim, Sang Eok Lee, Chan Hyung Kim, Woong Choi, Sang Jin Lee, Hyo-Yung Yun
OBJECTIVE: Spontaneous oscillation of tone of blood vessel called vasomotion cause vessel to flow blood which is an oscillation of flow into an organ. Microcirculation is sensitive to hypoxic condition and metabolism but mechanism of vasomotion is still poorly understood. DESIGN AND METHOD: Purpose: We studied involvement of metabolism-mediated regulation by intracellular ATP level of vasomotion in human gastric artery. METHODS: Conventional contractile measuring system and Western blot were used...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27713157/delayed-reendothelialization-with-rapamycin-is-rescued-by-the-addition-of-nicorandil-in-balloon-injured-rat-carotid-arteries
#6
Ying Qian Zhang, Feng Tian, Jin Song Chen, Yun Dai Chen, Ying Zhou, Bo Li, Qiang Ma, Ying Zhang
Rapamycin is an immunosuppressive agent that is added to drug eluting stents. It prevents restenosis, but it also impairs reendothelialization. Nicorandil is a hybrid agent with adenosine triphosphated (ATP)-sensitive K+ (KATP) channel opener and nitrate properties. It prevents oxidative stress and cell apoptosis induced by rapamycin in endothelial cells in vitro. However, whether nicorandil promotes reendothelialization after angioplasty delayed by rapamycin remains to be determined. Balloon injury model was established in SD rats...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27709781/activation-of-atp-sensitive-potassium-channels-facilitates-the-function-of-human-endothelial-colony-forming-cells-via-ca-2-akt-enos-pathway
#7
Yan Wu, Meng-Yu He, Jian-Kui Ye, Shu-Ying Ma, Wen Huang, Yong-Yue Wei, Hui Kong, Hong Wang, Xiao-Ning Zeng, Wei-Ping Xie
Accumulating data, including those from our laboratory, have shown that the opening of ATP-sensitive potassium channels (KATP ) plays a protective role in pulmonary vascular diseases (PVD). As maintainers of the endothelial framework, endothelial colony-forming cells (ECFCs) are considered excellent candidates for vascular regeneration in cases of PVD. Although KATP openers (KCOs) have been demonstrated to have beneficial effects on endothelial cells, the impact of KATP on ECFC function remains unclear. Herein, this study investigated whether there is a distribution of KATP in ECFCs and what role KATP play in ECFC modulation...
October 6, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27704082/evaluation-of-drug-mediated-arrhythmic-changes-in-spontaneous-beating-cardiomyocytes-by-afm
#8
A T Chen, S Zou
Arrhythmia caused by drug-induced cardiotoxicity is among the leading reasons for late-stage drug attrition and is therefore a core subject in safety testing of new compounds. Alternative methods such as surface and interface characterization approaches for assessing the drug-mediated cardiotoxicity should be promoted, in order to reduce, refine and replace the use of laboratory animals. Here, we investigate the possibility of using known human Ether-à-go-go-Related Gene (hERG) channel blockers to induce irregular beating patterns in the mouse and human induced pluripotent stem cell-derived (miPSC and hiPSC) cardiomyocyte (CM) model systems...
September 29, 2016: Analyst
https://www.readbyqxmd.com/read/27686005/emerging-drugs-for-the-treatment-of-angina-pectoris
#9
Cher-Rin Chong, Gao J Ong, John D Horowitz
Angina pectoris, or symptomatic myocardial ischaemia, reflects an impairment of coronary blood flow, and usually a deficiency of available myocardial energetics. Treatment options vary with the precise cause, which may vary with regards to the roles of increased myocardial oxygen demand versus reduced supply. Traditionally, organic nitrates, β-adrenoceptor antagonists, and non-dihydropyridine calcium antagonists were the only commonly used prophylactic anti-anginal agents. However, many patients failed to respond adequately to such therapy, and/or were unsuitable for their use...
October 6, 2016: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/27643252/os-02-06-physiological-regulation-of-vasomotion-by-intracellular-atp-mediated-system-in-human-artery
#10
Young Chul Kim, Dae Hoon Kim, Sang Eok Lee, Chan Hyung Kim, Woong Choi, Sang Jin Lee, Hyo-Yung Yun
OBJECTIVE: Spontaneous oscillation of tone of blood vessel called vasomotion cause vessel to flow blood which is an oscillation of flow into an organ. Microcirculation is sensitive to hypoxic condition and metabolism but mechanism of vasomotion is still poorly understood. DESIGN AND METHOD: HASH(0x40eb478) PURPOSE: We studied involvement of metabolism-mediated regulation by intracellular ATP level of vasomotion in human gastric artery. METHODS: Conventional contractile measuring system and Western blot were used...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27629960/intractable-coronary-spastic-angina-improvement-after-continuous-combined-estrogen-progestin-hormonal-contraception-use-in-a-premenopausal-woman
#11
Yusuke Adachi, Nahoko Ikeda, Kenichi Sakakura, Sachiho Netsu, Tatsuro Ibe, Hiroshi Wada, Shin-Ichi Momomura, Hideo Fujita
A 44-year-old woman, who had been previously diagnosed with coronary spastic angina and treated with standard medical therapy including calcium channel blockers, was admitted to our hospital due to chest pain at rest. Her chest pain attacks were concentrated just before and during menstruation. Despite the administration of an intravenous infusion of nitroglycerin and nicorandil, strong heart attacks with ST elevation occurred frequently after this admission. However, following continuous combined estrogen-progestin hormonal contraception use (estradiol plus dienogest), her attacks disappeared completely...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27622862/neuroprotective-effects-of-nicorandil-in-chronic-cerebral-hypoperfusion-induced-vascular-dementia
#12
Surbhi Gupta, Prabhat Singh, Bhupesh Sharma
BACKGROUND: Ischemia-induced chronic cerebral hypoperfusion (CCH) is associated with reduced cerebral blood flow and vascular dementia (VaD). Brain mitochondrial potassium (adenosine triphosphate-sensitive potassium [KATP]) channels have a beneficial role in various brain conditions. The utility of KATP channels in CCH-induced VaD is still unknown. The aim of this study is to investigate the role of nicorandil, a selective KATP channel opener, in CCH-induced VaD. METHODS: The method of 2-vessel occlusion (2VO) was used to induce CCH in mice...
September 9, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27613386/effects-of-intravenous-bolus-injection-of-nicorandil-on-renal-artery-flow-velocity-assessed-by-color-doppler-ultrasound
#13
Yukiko Shimamoto, Takashi Kubo, Kazumi Tanabe, Hiroki Emori, Yosuke Katayama, Tsuyoshi Nishiguchi, Akira Taruya, Takeyoshi Kameyama, Makoto Orii, Takashi Yamano, Akio Kuroi, Tomoyuki Yamaguchi, Kazushi Takemoto, Yoshiki Matsuo, Yasushi Ino, Atsushi Tanaka, Takeshi Hozumi, Masaki Terada, Takashi Akasaka
BACKGROUND: Previous animal studies have shown that a potassium channel opener, nicorandil, provokes vasodilation in renal microvasculature and increases renal blood flow. We conducted a clinical study that aimed to evaluate the effect of nicorandil on renal artery blood flow in comparison with nitroglycerin by using color Doppler ultrasound. METHODS: The present study enrolled 40 patients with stable coronary artery disease who had no renal arterial stenosis and renal parenchymal disease...
September 6, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27611876/additive-value-of-nicorandil-on-atp-for-further-inducing-hyperemia-in-patients-with-an-intermediate-coronary-artery-stenosis
#14
Yuhei Kobayashi, Hiroyuki Okura, Yoji Neishi, Tomitaka Higa, Yukari Kobayashi, Shiro Uemura, Kiyoshi Yoshida
BACKGROUND: The induction of hyperemia is of importance to precisely assess the functional significance of coronary artery lesions with fractional flow reserve (FFR). Adenosine or ATP alone is used widely in this setting; however, little is known about the additive value of nicorandil, which acts as a nitrate and a K-ATP channel opener, to induce further hyperemia. PATIENTS AND METHODS: A total of 183 intermediate native coronary artery lesions from 112 patients were prospectively enrolled into this study...
September 8, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27593840/comparison-of-the-effects-and-mechanism-of-the-curcumin-with-different-acting-drugs-in-experimental-vasospasm-after-subarachnoid-hemorrhage
#15
Hasan Emre Aydin, Nuriye Ezgi Bektur, Zuhtu Ozbek, Setenay Oner, Cengiz Baycu, Fatma Sultan Kiliç
AIM: Cerebral vasospasm following subarachnoid hemorrhage (SAH) is the most important complication which effects mortality and morbidity of patients with intracranial aneurysm although effective treatment. Today, the mechanisms of vasospasm is not understood in spite of experimetal and clinical researches. The aim of our study to investigate the effect of curcumin which used in medical treatment of some illness and known antioxidant drug on vasospasm following SAH. MATERIAL AND METHODS: In this study, 200-250 gr weight and 64 rats were divided into 7 groups...
May 25, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27562702/in%C3%A2-vitro-effect-of-nicorandil-on-the-carbachol-induced-contraction-of-the-lower-esophageal-sphincter-of-the-rat
#16
Tomonori Shimbo, Takeshi Adachi, Susumu Fujisawa, Mai Hongoh, Takayoshi Ohba, Kyoichi Ono
The lower esophageal sphincter (LES) is a specialized region of the esophageal smooth muscle that allows the passage of a swallowed bolus into the stomach. Nitric oxide (NO) plays a major role in LES relaxation. Nicorandil possesses dual properties of a NO donor and an ATP-sensitive potassium channel (KATP channel) agonist, and is expected to reduce LES tone. This study investigated the mechanisms underlying the effects of nicorandil on the LES. Rat LES tissues were placed in an organ bath, and activities were recorded using an isometric force transducer...
August 2016: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/27488764/nitrates-for-the-prevention-of-cardiac-morbidity-and-mortality-in-patients-undergoing-non-cardiac-surgery
#17
REVIEW
Na Zhao, Jin Xu, Balwinder Singh, Xuerong Yu, Taixiang Wu, Yuguang Huang
BACKGROUND: Cardiac complications are not uncommon in patients undergoing non-cardiac surgery, especially in patients with coronary artery disease (CAD) or at high risk of CAD. Perioperative cardiac complications can lead to mortality and morbidity, as well as higher costs for patient care. Nitrates, which are among the most commonly used cardiovascular drugs, perform the function of decreasing cardiac preload while improving cardiac blood perfusion. Sometimes, nitrates are administered to patients undergoing non-cardiac surgery to reduce the incidence of cardiac complications, especially for patients with CAD...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27439628/cardioprotection-by-conditioning-mimetic-drugs
#18
Elpidio Santillo, Monica Migale, Demetrio Postacchini, Fabrizio Balestrini, Raffaele Antonelli Incalzi
BACKGROUND: At present, ischemic heart disease (IHD) is one of the main causes of morbidity and mortality world-wide. An important insight into both IHD pathophysiology and cardioprotection was achieved in 1986 when Murry et al. described for the first time the ischemic preconditioning (IP). IP can be defined as an innate phenomenon by which brief episodes of ischemia confer protection to a tissue from a subsequent more protracted ischemic insult. Suggested mechanisms explaining IP comprise the action of circulating substances (e...
July 19, 2016: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27423333/nicorandil-induced-penile-ulceration-a-case-report
#19
Darren Yap, Omar Aboumarzouk, Christopher Bates
BACKGROUND: Penile ulceration in older patients is commonly neoplastic or infective. However, there are rarer causes of these ulcerations that we have to exclude. We present a rare complication of penile ulceration secondary to nicorandil, a nicotinamide ester. CASE PRESENTATION: An 86-year-old white British man was referred with a bloody discharge from under his phimotic foreskin and a lump on the shaft of his penis for the past year. He had angina which has been controlled with nicorandil for the past 5 years...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27358172/treatment-of-angina-pectoris-associated-with-coronary-microvascular-dysfunction
#20
Peter Ong, Anastasios Athanasiadis, Udo Sechtem
Treatment of angina pectoris associated with coronary microvascular dysfunction is challenging as the underlying mechanisms are often diverse and overlapping. Patients with type 1 coronary microvascular dysfunction (i.e. absence of epicardial coronary artery disease and myocardial disease) should receive strict control of their cardiovascular risk factors and thus receive statins and ACE-inhibitors in most cases. Antianginal medication consists of ß-blockers and/or calcium channel blockers. Second line drugs are ranolazine and nicorandil with limited evidence...
August 2016: Cardiovascular Drugs and Therapy
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