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https://www.readbyqxmd.com/read/29891250/effects-of-early-intracoronary-administration-of-nicorandil-during-percutaneous-coronary-intervention-in-patients-with-acute-myocardial-infarction
#1
Chunguang Feng, Yi Liu, Lulu Wang, Dongdong Niu, Bing Han
BACKGROUND: To determine whether nicorandil administration distal to the thrombus in the coronary artery during percutaneous coronary intervention (PCI) in acute ST-segment elevation myocardial infarction (STEMI) patients reduced the incidence of no-reflow phenomenon, reperfusion injury, and adverse events. METHODS: This randomised controlled trial involved 170 STEMI patients who underwent PCI. All patients underwent thrombectomy and tirofiban injection (10μg/kg) distal to the vascular lesion via a suction catheter, followed by nicorandil (84 patients; 2mg) or saline injection (86 patients; 2mL) at the same site...
May 22, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29874661/treatment-of-angina-where-are-we
#2
Cristina Balla, Rita Pavasini, Roberto Ferrari
Ischaemic heart disease is a major cause of death and disability worldwide, while angina represents its most common symptom. It is estimated that approximately 9 million patients in the USA suffer from angina and its treatment is challenging, thus the strategy to improve the management of chronic stable angina is a priority. Angina might be the result of different pathologies, ranging from the "classical" obstruction of a large coronary artery to alteration of the microcirculation or coronary artery spasm...
June 6, 2018: Cardiology
https://www.readbyqxmd.com/read/29858919/intravenous-nicorandil-versus-adenosine-for-fractional-flow-reserve-measurement-a-crossover-randomized-study
#3
Takeshi Nishi, Hideki Kitahara, Yoshihide Fujimoto, Takashi Nakayama, Kengo Nagashima, Hideki Hanaoka, Yoshio Kobayashi
Nicorandil has vasodilatory effects on both the epicardial coronary arteries and the coronary microvasculature, thereby increasing coronary blood flow. The objective of the present study was to investigate the effectiveness of intravenous (IV) nicorandil infusion for fractional flow reserve (FFR) measurement. In this crossover randomized study, 49 patients underwent FFR measurement with a consecutive randomized order of patient-blind infusions of continuous IV adenosine administration and a single bolus IV administration of nicorandil...
June 1, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29767853/nicorandil-induced-ulcerations-a-10-year-observational-study-of-all-cases-spontaneously-reported-to-the-french-pharmacovigilance-network
#4
Valérie Babic, Nadine Petitpain, Claire Guy, Philippe Trechot, Anne Claire Bursztejn, Jean Luc Faillie, Thierry Vial, Jean Luc Schmutz, Pierre Gillet
Nicorandil-induced ulcers remain often poorly recognised, with a late diagnosis and an inadequate management. We aimed to provide a clinical overview of the 148 spontaneously reported cases of nicorandil-induced ulcers to the French pharmacovigilance network between 2005 and 2014 and to complete this picture with worldwide published cases over the same period. Spontaneously reported nicorandil-induced ulcers were mainly mucosal (oral and anal) with a previous trauma in 23·0% of patients, revealed by a severe complication in 12·8% of cases...
May 16, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29748072/nicorandil-reduces-burn-wound-progression-by-enhancing-skin-blood-flow
#5
Jaehoon Choi, Ryeolwoo Kim, Junhyung Kim, Woonhyeok Jeong, Sang Woo Park, Hyoun Wook Lee, Ho Yun Chung
We assessed whether nicorandil, an adenosine triphosphate-sensitive K + channel opener, reduces burn wound progression in a rat comb burn model. A total of 24 rats were used. Following thermal injury, one dose of nicorandil (10 or 30 mg/kg) was administered intragastrically twice daily for 3 days. At days 1 and 3 after injury, skin was harvested for histopathological examination and protein isolation. Rats treated with the 10-mg/kg and 30-mg/kg doses of nicorandil exhibited significantly increased tissue survival in the zone of stasis at days 1 and 3 after injury...
April 12, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29743901/effect-of-nicorandil-administration-on-myocardial-microcirculation-during-primary-percutaneous-coronary-intervention-in-patients-with-acute-myocardial-infarction
#6
Chunguang Feng, Bing Han, Yi Liu, Lulu Wang, Dongdong Niu, Ming Lou, Cunzhi Lu
Introduction: Prevention of the no-reflow phenomenon has a crucial role in primary percutaneous coronary intervention (P-PCI) procedures. Aim: To assess the effects of early intracoronary administration of nicorandil (NIC) during P-PCI on myocardial microcirculation in patients with acute myocardial infarction (AMI). Material and methods: A total of 120 patients with first acute anterior wall ST segment elevation myocardial infarction who underwent P-PCI were randomly divided into two groups: the NIC group (A, n = 60) and the placebo group (B, n = 60)...
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29740934/preventive-effect-of-nicorandil-on-contrast-induced-nephropathy-a-meta-analysis-of-randomized-controlled-trials
#7
Shuang Li, Lin Wang, Yucai Liu, Qiang Hu
BACKGROUNDS: Contrast-induced nephropathy (CIN) is a common and serious side effect in patients undergoing angiocardiography or radiological procedures. We aimed to comprehensively assess the impact of nicorandil on CIN, by gathering currently available data. METHODS AND RESULTS: We searched three main electric databases (Medline/PubMed, EMBASE and Cochrane Central Register of Controlled Trials) from inception through April, 2017. Four randomized controlled trials involving 730 participants were included...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29735436/-nicorandil-improves-cognitive-dysfunction-in-mice-with-streptozotocin-induced-diabetes
#8
Wen-Hui Yan, Chun-Xi Zhang, Tong Xing, Xue Gong, Yu-Xuan Yang, Yi-Nuo Li, Xuan Liu, Jiamaliding Ayijiang, Ye Yu, Meng Zhang, Li-Na Chen
OBJECTIVE: To observe the protective effects of potassium channel opener nicorandil against cognitive dysfunction in mice with streptozotocin (STZ)-induced diabetes. METHODS: C57BL/6J mouse models of type 1 diabetes mellitus (T1DM) were established by intraperitoneal injection of STZ and received daily treatment with intragastric administration of nicorandil or saline (model group) for 4 consecutive weeks, with normal C57BL/6J mice serving as control. Fasting blood glucose level was recorded every week and Morris water maze was used to evaluate the cognitive behavior of the mice in the 4th week...
April 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29726480/intracoronary-nicorandil-and-the-prevention-of-the-no-reflow-phenomenon-during-primary-percutaneous-coronary-intervention-in-patients-with-acute-st-segment-elevation-myocardial-infarction
#9
Qi Qi, Jinghui Niu, Tao Chen, Hongshan Yin, Tao Wang, Zhian Jiang
BACKGROUND This study aimed to investigate intracoronary nicorandil treatment on the no-reflow phenomenon (NRP) during primary percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) and to compare nicorandil with sodium nitroprusside. MATERIAL AND METHODS Patients with sustained acute STEMI who underwent primary PCI (N=120) were randomly assigned to three groups: the nicorandil-treated group (N=40) had 2 mg of nicorandil injected into the coronary artery at 2 mm beyond the occlusion with balloon pre-dilation; the sodium nitroprusside-treated group (N=40) underwent the same procedure, but with 200 μg of sodium nitroprusside; the control group (N=40) received PCI and balloon pre-dilation only...
May 4, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29669963/protective-effect-of-remote-ischemic-preconditioning-on-myocardial-damage-after-percutaneous-coronary-intervention-in-stable-angina-patients-with-complex-coronary-lesions-subanalysis-of-a-randomized-controlled-trial
#10
Kentaro Ejiri, Toru Miyoshi, Kunihisa Kohno, Makoto Nakahama, Masayuki Doi, Mitsuru Munemasa, Masaaki Murakami, Atsushi Takaishi, Kazufumi Nakamura, Hiroshi Ito
BACKGROUND: The effect of remote ischemic preconditioning (RIPC) on periprocedural myocardial damage (pMD) in patients undergoing percutaneous coronary intervention (PCI) is controversial. The aim of this study was to investigate the effect of RIPC or intravenous nicorandil on pMD following elective PCI in a subgroup of patients with complex coronary lesions from a multicenter randomized controlled trial.Methods and Results:Patients with stable angina who underwent elective PCI were assigned to 3 groups: control, upper-limb RIPC or intravenous nicorandil...
April 18, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29659585/protective-effect-of-nicorandil-on-myocardial-injury-following-percutaneous-coronary-intervention-in-older-patients-with-stable-coronary-artery-disease-secondary-analysis-of-a-randomized-controlled-trial-rinc
#11
Norifumi Kawakita, Kentaro Ejiri, Toru Miyoshi, Kunihisa Kohno, Makoto Nakahama, Masayuki Doi, Mitsuru Munemasa, Masaaki Murakami, Kazufumi Nakamura, Hiroshi Ito
BACKGROUND: Our previous study examined an effect of remote ischemic preconditioning (RIPC) or intravenous nicorandil on reduction of periprocedural myocardial injury (pMI) following percutaneous coronary intervention (PCI) in patients with stable coronary artery disease (CAD). We further investigated the effect of RIPC or nicorandil on pMI in older patients. METHODS: Patients with stable CAD who planned to undergo PCI were assigned to a 1:1:1 ratio to control, intravenous nicorandil, or upper-limb RIPC groups...
2018: PloS One
https://www.readbyqxmd.com/read/29618446/effects-of-qibaipingfei-capsules-on-pulmonary-vascular-relaxation-through-katp-channel-activation-by-the-no-cgmp-signaling-pathway
#12
Jie Zhu, Baoqin Wang, Mei Lu, Jiabing Tong, Cheng Yang, Zegeng Li
This research explores the effects of Qibaipingfei (QBPF) capsules on pulmonary vascular relaxation in vitro and the relationship of the ATP-sensitive K+ (KATP) channel and nitric oxide (NO) pathway. Vasodilator effects of QBPF (0.125-2 g/kg) on rat pulmonary artery rings were observed using a multi-wire myograph system. The maximum relaxation (Emax ) of QBPF was detected following treatment involving endothelial denudation, Nω-nitro-L-arginine methyl ester (L-NAME), 1H-[1,2,4] oxadiazolo[4,3-α]quinoxalin-1-one (ODQ), or glyburide (GLYB)...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29579542/nicorandil-alleviates-ovalbumin-induced-airway-inflammation-in-a-mouse-model-of-asthma
#13
Dalia H El-Kashef
Nicorandil is an antianginal drug that has anti-inflammatory property. This study aimed to investigate the effects of nicorandil on allergic asthma induced by ovalbumin (OVA) in mice in comparison with dexamethasone. Mice were sensitized to OVA (on days 0 and 7) and challenged with OVA three times (on days 14, 15 and 16). Nicorandil was given orally for 5 days 1 h before OVA treatment in days of challenge. Progression of asthma was accompanied by significant elevation in the lung/body weight index, LDH, total protein, IL-13 and NF-κB levels besides inflammatory cell counts in BALF; Also pulmonary MDA and NO contents were significantly increased but GSH and SOD levels were decreased...
April 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29545940/renoprotective-effect-of-nicorandil-in-patients-undergoing-percutaneous-coronary-intervention-a-meta-analysis-of-4-randomized-controlled-trials
#14
Xiaobing Wang, Jin Geng, Hong Zhu, Changying Xing
Many studies have evaluated the renoprotective effect of nicorandil in patients undergoing percutaneous coronary intervention (PCI), but the results are inconsistent. We therefore conducted this meta-analysis to evaluate the protective effect of nicorandil against contrast-induced nephropathy (CIN). We searched PubMed, Embase, the Cochrane Library, Web of Science, and clinical trials database. Studies compared the nicorandil (plus hydration) with hydration alone in patients receiving PCI were eligible. The primary outcome was the incidence of CIN...
February 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29522711/role-of-nitric-oxide-and-katp-channel-in-the-protective-effect-mediated-by-nicorandil-in-bile-duct-ligation-induced-liver-fibrosis-in-rats
#15
Yasmin S Mohamed, Lamiaa A Ahmed, Hesham A Salem, Azza M Agha
Liver fibrosis is one of the most serious conditions affecting patients worldwide. In the present study, the role of nitric oxide and KATP channel was investigated for the first time in the possible protection mediated by nicorandil in bile duct ligation-induced liver fibrosis in rats. Nicorandil (3 mg/kg/day) was given orally 24 h after bile duct ligation for 14 days till the end of the experiment. Nicorandil group showed marked improvement in liver function tests, hepatic oxidative stress and inflammatory markers as well as inducible and endothelial nitric oxide synthase protein expressions...
May 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29508065/nicorandil-increased-the-cerebral-blood-flow-via-nitric-oxide-pathway-and-atp-sensitive-potassium-channel-opening-in-mice
#16
Masakazu Kotoda, Tadahiko Ishiyama, Kazuha Mitsui, Sohei Hishiyama, Takashi Matsukawa
PURPOSE: Nicorandil has dual properties and acts as a nitric oxide donor and an ATP-sensitive potassium (KATP ) channel opener. Considering its pharmacological profile, nicorandil might exert protective effects on the brain as well as on the heart. The purpose of this study was to directly evaluate the effect of nicorandil on cerebral blood flow (CBF) in mice using a transcranial Doppler method. METHODS: Under general anesthesia, the nicorandil groups received a single-bolus intraperitoneal injection of the respective doses of nicorandil (1, 5, or 10 mg/kg), while the control group received vehicle only...
April 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29475566/nicorandil-and-cutaneous-ulcerations-their-misdiagnosis-and-consequences-illustration-by-five-cases-reports-and-a-review-of-the-french-pharmacovigilance-database
#17
Johana Béné, Olivier Carpentier, Sonia Sabanowski, Marie-Laure Laroche, Marie-Noëlle Beyens, Marc Lambert, Sophie Gautier
While physicians increasingly recognize nicorandil-related mucocutaneous ulcerations, there are still misdiagnoses, particularly in the case of unusual location and late onset ulceration after nicorandil introduction. The goal of our study was to remind clinicians about the link between nicorandil use and the development of cutaneous ulcerations and to highlight the risk of misdiagnosis. We describe five reports diagnosed by the same dermatologist, complemented by an analysis of the French pharmacovigilance database (FPVD) from 1 January 1994 to 5 January 2017...
January 31, 2018: Thérapie
https://www.readbyqxmd.com/read/29438704/nicorandil-inhibits-mechanical-allodynia-induced-by-paclitaxel-by-activating-opioidergic-and-serotonergic-mechanisms
#18
Marcela I Morais, Felipe F Rodrigues, Sarah O A M Costa, Franciele A Goulart, Fábio C Costa, Ivo S F Melo, Paulo S A Augusto, Marcela M G B Dutra, Ângelo de Fátima, Márcio M Coelho, Renes R Machado
Recently, we demonstrated that nicorandil exhibits activities in models of inflammatory and nociceptive pain. In the present study, we extended this investigation by evaluating the effects of nicorandil in models of neuropathic pain induced by paclitaxel or nerve injury in mice. Four intraperitoneal (i.p.) injections of paclitaxel (2 mg/kg.day, cumulative dose 8 mg/kg) or chronic constriction injury (CCI) of the sciatic nerve induced a long lasting mechanical allodynia. Per os (p.o.) administration of two doses of nicorandil (50, 100 and 150 mg/kg) on the 14th day after the first paclitaxel injection attenuated the mechanical allodynia...
April 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29420355/inotropic-effects-of-nicorandil-on-cardiac-contractility-assessed-by-left-ventricular-pressure-volume-relationship-analyses-in-anesthetized-monkeys
#19
Tomomichi Ishizaka, Yu Yoshimatsu, Yu Maeda, Katsuyoshi Chiba, Kazuhiko Mori
Nicorandil is a representative antianginal drug that has dual properties of a nitrate and adenosine triphosphate-sensitive potassium (KATP) channel agonist; however, its effects on integrated cardiac function have not been fully understood. This study was conducted to clarify the functional, hemodynamic, and electrophysiological effects of nicorandil using ventricular pressure-volume loop analysis in isoflurane-anesthetized monkeys. Nicorandil was given intravenously at therapeutic doses of 0.2 and 2 mg/kg over 10 minutes to cynomolgus monkeys (n = 5) with a pause of 10 minutes between the 2 doses...
February 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29412163/the-protective-effect-of-nicorandil-on-cardiomyocyte-apoptosis-after-coronary-microembolization-by-activating-nrf2-ho-1-signaling-pathway-in-rats
#20
Wenkai He, Qiang Su, Jiabao Liang, Yuhan Sun, Xiantao Wang, Lang Li
BACKGROUND: Myocardial apoptosis is considered to be the chief cause of progressive cardiac dysfunction induced by coronary microembolization (CME), and the Nrf2/HO-1 signaling pathway is involved in CME-induced myocardial apoptosis. Nicorandil (NIC) has multiple beneficial cardiovascular effects on myocardial injury. Therefore, this study was undertaken to analyze the role of NIC pretreatment in the inhibiting myocardial apoptosis after CME in rats. METHODS: Forty rats were divided into Sham group, CME group, CME plus NIC (NIC) group, and CME plus AAV9-Nrf2 (AAV9-Nrf2) group (n = 10 per group)...
February 19, 2018: Biochemical and Biophysical Research Communications
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