Zhangwei Chen, Su Li, Muyin Liu, Ming Yin, Jinxiang Chen, Youran Li, Qiyu Li, You Zhou, Yan Xia, Ao Chen, Danbo Lu, Chenguang Li, Yuqiong Chen, Juying Qian, Junbo Ge
Mitochondria-associated ferroptosis exacerbates cardiac microvascular dysfunction in diabetic cardiomyopathy (DCM). Nicorandil, an ATP-sensitive K+ channel opener, protects against endothelial dysfunction, mitochondrial dysfunction, and DCM; however, its effects on ferroptosis and mitophagy remain unexplored. The present study aimed to assess the beneficial effects of nicorandil against endothelial ferroptosis in DCM and the underlying mechanisms. Cardiac microvascular perfusion was assessed using a lectin perfusion assay, while mitophagy was assessed via mt-Keima transfection and transmission electron microscopy...
January 11, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society