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https://www.readbyqxmd.com/read/29679071/determinants-of-treatment-response-in-first-episode-psychosis-an-18-f-dopa-pet-study
#1
Sameer Jauhar, Mattia Veronese, Matthew M Nour, Maria Rogdaki, Pamela Hathway, Federico E Turkheimer, James Stone, Alice Egerton, Philip McGuire, Shitij Kapur, Oliver D Howes
Psychotic illnesses show variable responses to treatment. Determining the neurobiology underlying this is important for precision medicine and the development of better treatments. It has been proposed that dopaminergic differences underlie variation in response, with striatal dopamine synthesis capacity (DSC) elevated in responders and unaltered in non-responders. We therefore aimed to test this in a prospective cohort, with a nested case-control comparison. 40 volunteers (26 patients with first-episode psychosis and 14 controls) received an 18 F-DOPA Positron Emission Tomography scan to measure DSC (Kicer ) prior to antipsychotic treatment...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29677472/translating-immunology-into-therapeutic-concepts-for-inflammatory-bowel-disease
#2
Holm H Uhlig, Fiona Powrie
Inflammatory bowel disease (IBD) defines a spectrum of complex disorders. Understanding how environmental risk factors, alterations of the intestinal microbiota, and polygenetic and epigenetic susceptibility impact on immune pathways is key for developing targeted therapies. Mechanistic understanding of polygenic IBD is complemented by Mendelian disorders that present with IBD, pharmacological interventions that cause colitis, autoimmunity, and multiple animal models. Collectively, this multifactorial pathogenesis supports a concept of immune checkpoints that control microbial-host interactions in the gut by modulating innate and adaptive immunity, as well as epithelial and mesenchymal cell responses...
April 26, 2018: Annual Review of Immunology
https://www.readbyqxmd.com/read/29669821/recognition-of-recurrent-protein-expression-patterns-in-pediatric-acute-myeloid-leukemia-identified-new-therapeutic-targets
#3
Fieke W Hoff, Chenyue W Hu, Yihua Qiu, Andrew Ligeralde, Suk-Young Yoo, Hasan Mahmud, Eveline Sjm De Bont, Amina A Qutub, Terzah M Horton, Steven M Kornblau
Heterogeneity in the genetic landscape of pediatric acute myeloid leukemia (AML) makes personalized medicine challenging. As genetic events are mediated by the expression and function of proteins, recognition of recurrent protein patterns could enable classification of pediatric AML patients and could reveal crucial protein dependencies. This could help to rationally select combinations of therapeutic targets. To determine if protein expression levels could be clustered into functionally relevant groups, custom Reverse Phase Protein Arrays (RPPA) were performed on pediatric AML (n=95) and CD34+ normal bone marrow (n=10) clinical specimens using 194 validated antibodies...
April 18, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29668600/chilean-gastric-cancer-task-force-a-study-protocol-to-obtain-a-clinical-and-molecular-classification-of-a-cohort-of-gastric-cancer-patients
#4
Gareth I Owen, Mauricio P Pinto, Ignacio N Retamal, María F Fernádez, Betzabe Cisternas, Sebastian Mondaca, Cesar Sanchez, Hector Galindo, Bruno Nervi, Carolina Ibañez, Francisco Acevedo, Jorge Madrid, José Peña, Maria Loreto Bravo, Maria Jose Maturana, Miguel Cordova-Delgado, Diego Romero, Nathaly de la Jara, Javiera Torres, Maria Rodriguez-Fernandez, Manuel Espinoza, Carlos Balmaceda, Matías Freire, Valentina Gárate-Calderón, Fernando Crovari, Paula Jimenez-Fonseca, Alberto Carmona-Bayonas, Ariel Zwenger, Ricardo Armisen, Alejandro H Corvalan, Marcelo Garrido
Gastric cancer (GC) is the world's second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to "one size fits all" therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29661504/stress-induced-hyperglycemia-on-complications-in-non-critically-elderly-hospitalized-patients
#5
F J Carrasco-Sánchez, J Carretero-Gómez, R Gómez-Huelgas, M A Garcia-Ordoñez, M V Pardo-Ortega, B de Escalante-Yanguela, L Mateos-Polo, F Formiga, J Ena
AIMS: Hospital complications and hyperglycemia are common in elderly patients during hospitalization. Our aim was to analyze the relationship between hyperglycemia and hospital complications in an ageing population. METHODS: We conducted an observational study to evaluate the association between maximum blood glucose (MBG) levels and hospital complications. Patients were stratified according to the quartiles of MBG levels. Diabetes mellitus (DM) was determined by patient history and/or admission glycated hemoglobin (HbA1c) level ≥6...
April 13, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29658620/impact-of-economic-sanctions-on-access-to-noncommunicable-diseases-medicines-in-the-islamic-republic-of-iran
#6
Mehrnaz Kheirandish, Vida Varahrami, Abbas Kebriaeezade, Abdol Majid Cheraghali
Background: It has been argued that economic sanctions and the economic crisis have adversely affected access to drugs. Aim: To assess the impact of economic sanctions on the Iranian banking system in 2011 and Central Bank in 2012 on access to and use of drugs for noncommunicable diseases (NCDs). Methods: An interrupted time series study assessed the effects of sanctions on drugs for diabetes (5 drug groups), asthma (5 drug groups), cancer (14 drugs) and multiple sclerosis (2 drugs)...
April 5, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29648644/management-of-patients-with-coronary-heart-disease-in-family-medicine-correlates-of-quality-of-care
#7
Ksenija Tušek-Bunc, Davorina Petek
Objectives: Family medicine plays an important role in quality of care (QoC) of coronary heart disease (CHD) patients. This study's aim was to determine the quality of secondary cardiovascular disease prevention in the everyday practice of family physicians. Design: This study was observational cross-sectional. Setting: About 36 randomly selected family medicine practices stratified by size and location in Slovenia. Participants: CHD patients randomly selected from a patient register available in family medicine practices...
April 10, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29627770/essential-medicines-for-emergency-care-in-africa
#8
Morgan C Broccoli, Jennifer L Pigoga, Mulinda Nyirenda, Lee Wallis, Emilie J Calvello Hynes
OBJECTIVES: Essential medicines lists (EMLs) are efficient means to ensure access to safe and effective medications. The WHO has led this initiative, generating a biannual EML since 1977. Nearly all countries have implemented national EMLs based on the WHO EML. Although EMLs have given careful consideration to many public health priorities, they have yet to comprehensively address the importance of medicines for treating acute illness and injury. METHODS: We undertook a multistep consensus process to establish an EML for emergency care in Africa...
April 7, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29626587/metabolite-changes-in-risk-of-type-2-diabetes-mellitus-in-cohort-studies-a-systematic-review-and-meta-analysis
#9
Jeong-Eun Park, HyeRin Lim, Jun Woo Kim, Kwang-Hee Shin
AIMS: Fasting plasma glucose, oral glucose tolerance test, and glycated hemoglobin are diagnostic markers for type 2 diabetes mellitus (T2DM). However, it is necessary to detect physiological changes in T2DM rapidly and stratify diabetic stage using other biomarkers. We performed a systematic review and meta-analysis to contribute to the development of objective and sensitive diagnostic indicators by integrating metabolite biomarkers derived from large-scale cohort studies. METHODS: We searched for metabolomics studies of T2DM cohort in PubMed, Scopus, and Web of Science for studies published within the last 10 years from January 2008 to February 2017...
April 4, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29622982/cardiovascular-disease-and-abo-blood-groups-in-africans-are-blood-group-a-individuals-at-higher-risk-of-ischemic-disease-a-pilot-study
#10
Djibril Marie Ba, Mamadou Saidou Sow, Aminata Diack, Khadidiatou Dia, Mouhamed Cherif Mboup, Pape Diadie Fall, Moussa Daouda Fall
Background: Since the discovery of the ABO blood group system by Karl Landsteiner in 1901, several reports have suggested an important involvement of the ABO blood group system in the susceptibility to thrombosis. Assessing that non-O blood groups in particular A blood group confer a higher risk of venous and arterial thrombosis than group O.Epidemiologic data are typically not available for all racial and ethnics groups.The purpose of this pilot study was to identify a link between ABO blood group and ischemic disease (ID) in Africans, and to analyze whether A blood group individuals were at higher risk of ischemic disease or not...
December 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29621253/a-correlation-comparison-between-altmetric-attention-scores-and-citations-for-six-plos-journals
#11
Wenya Huang, Peiling Wang, Qiang Wu
This study considered all articles published in six Public Library of Science (PLOS) journals in 2012 and Web of Science citations for these articles as of May 2015. A total of 2,406 articles were analyzed to examine the relationships between Altmetric Attention Scores (AAS) and Web of Science citations. The AAS for an article, provided by Altmetric aggregates activities surrounding research outputs in social media (news outlet mentions, tweets, blogs, Wikipedia, etc.). Spearman correlation testing was done on all articles and articles with AAS...
2018: PloS One
https://www.readbyqxmd.com/read/29610289/e-cadherin-ros1-inhibitor-synthetic-lethality-in-breast-cancer
#12
Ilirjana Bajrami, Rebecca Marlow, Marieke van de Ven, Rachel Brough, Helen N Pemberton, Jessica Frankum, Feifei Song, Rumana Rafiq, Asha Konde, Dragomir B Krastev, Malini Menon, James Campbell, Aditi Gulati, Rahul Kumar, Stephen J Pettitt, Mark D Gurden, Marta Llorca Cardenosa, Irene Chong, Patrycja Gazinska, Fredrik Wallberg, Elinor J Sawyer, Lesley-Ann Martin, Mitch Dowsett, Spiros Linardopoulos, Rachael Natrajan, Colm J Ryan, Patrick W B Derksen, Jos Jonkers, Andrew N J Tutt, Alan Ashworth, Christopher J Lord
The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit this characteristic are not available. Using perturbation screens in breast tumor cells with CRISPR/Cas9-engineered CDH1 mutations, we identified synthetic lethality between E-cadherin deficiency and inhibition of the tyrosine kinase ROS1. Data from large-scale genetic screens in molecularly diverse breast tumor cell lines established that the E-cadherin/ROS1 synthetic lethality was not only robust in the face of considerable molecular heterogeneity but was also elicited with clinical ROS1 inhibitors, including foretinib and crizotinib...
April 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29608433/effects-of-education-and-health-literacy-on-postoperative-hospital-visits-in-bariatric-surgery
#13
Stephen T Mahoney, Dahlia Tawfik-Sexton, Paula D Strassle, Timothy M Farrell, Meredith C Duke
BACKGROUND: Hospital readmissions following bariatric surgery are high and it is necessary to identify modifiable risk factors to minimize this postoperative cost. We hypothesize that lower levels of education and health literacy are associated with increased risks of nonadherence, thus leading to increased emergency department (ED) visits and preventable readmissions postoperatively. METHODS: Bariatric surgery patients presenting between October 2015 and December 2016 were administered a preoperative questionnaire that measured education level and the Rapid Estimate of Adult Literacy in Medicine-Short Form (REALM-SF) health literacy test...
April 2, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29600410/butyrylcholinesterase-level-as-an-independent-factor-of-erythropoiesis-stimulating-agent-resistance-in-patients-on-maintenance-hemodialysis-a-single-center-cross-sectional-study
#14
Teppei Okamoto, Shingo Hatakeyama, Yoshimi Tanaka, Kengo Imanishi, Tooru Takashima, Fumitada Saitoh, Takuya Koie, Tadashi Suzuki, Chikara Ohyama
BACKGROUND: Erythropoiesis-stimulating agent (ESA) responsiveness is related to the nutritional status of patients on hemodialysis (HD). Serum butyrylcholinesterase (BChE), an alpha-glycoprotein, may decrease in case of malnutrition. We investigated whether BChE was independently related to ESA resistance in patients on HD. METHODS: The laboratory data and ESA resistance index (ERI), defined as ESA dosage per week divided by dry weight and hemoglobin, were investigated in 215 patients on HD between July and September 2017...
March 29, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29600351/a-digital-language-divide-the-relationship-between-internet-medication-refills-and-medication-adherence-among-limited-english-proficient-lep-patients
#15
Alejandra Casillas, Gerardo Moreno, Jonathan Grotts, Chi-Hong Tseng, Leo S Morales
BACKGROUND: Use of an Internet portal to refill medicines positively affects medication adherence among English-speakers. No prior studies, however, have specifically examined the relationship between Internet refills and medication adherence among patients who are limited English proficient (LEP). OBJECTIVES: (1) Examine the relationship between Internet medication refill system use and medication adherence among linguistically diverse patients with chronic conditions and (2) compare this relationship between LEP and English-proficient (EP) patients...
March 29, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29587861/pretreatment-with-coenzyme-q10-improves-ovarian-response-and-embryo-quality-in-low-prognosis-young-women-with-decreased-ovarian-reserve-a-randomized-controlled-trial
#16
Yangying Xu, Victoria Nisenblat, Cuiling Lu, Rong Li, Jie Qiao, Xiumei Zhen, Shuyu Wang
BACKGROUND: Management of women with reduced ovarian reserve or poor ovarian response (POR) to stimulation is one of the major challenges in reproductive medicine. The primary causes of POR remain elusive and oxidative stress was proposed as one of the important contributors. It has been suggested that focus on the specific subpopulations within heterogeneous group of poor responders could assist in evaluating optimal management strategies for these patients. This study investigated the effect of anti-oxidant treatment with coenzyme Q10 (CoQ10) on ovarian response and embryo quality in young low-prognosis patients with POR...
March 27, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29565109/white-book-on-physical-and-rehabilitation-medicine-prm-in-europe-chapter-8-the-prm-specialty-in-the-healthcare-system-and-society
#17
(no author information available yet)
In the context of the White Book of Physical and Rehabilitation Medicine (PRM) in Europe, this paper deals with a global overview of the role of PRM in healthcare systems in Europe. Several documents and reports by WHO and the UN call for the worldwide strengthening of rehabilitation as a key health strategy of the 21st century. Therefore, further implementation of PRM in healthcare systems is crucial. Many aspects need to be considered when implementing PRM in a health system. Since PRM should be provided along the whole continuum of care, a specific phase model has been developed...
April 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29561691/dual-autonomies-divergent-approaches-how-stratification-in-medical-education-shapes-approaches-to-patient-care
#18
Tania M Jenkins
The United States relies on international and osteopathic medical graduates ("non-USMDs") to fill one third of residency positions because of a shortage of American MD graduates ("USMDs"). Non-USMDs are often informally excluded from top residency positions, while USMDs tend to fill the most prestigious residencies. Little is known, however, about whether the training in these different settings is comparable or how it impacts patients. Drawing on 23 months of ethnographic fieldwork and 123 interviews, I compare training at two internal medicine programs: a community hospital staffing 90% non-USMDs and a university hospital staffing 99% USMDs...
March 1, 2018: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/29561354/endotypes-in-allergic-diseases
#19
Ioana Agache, Liliana Rogozea
PURPOSE OF REVIEW: The precision medicine concept is both appealing and challenging. We review here the recent findings in the endotype-driven approach for major allergic diseases. RECENT FINDINGS: Stratified medicine for different allergic diseases can identify patients who are more likely to benefit or experience an adverse reaction in response to a given therapy and anticipate their long-term outcome and vital risk. In addition, this approach potentially facilitates drug development and prevention strategies...
March 20, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29557872/increasing-industry-support-is-associated-with-higher-research-productivity-in-orthopaedic-surgery
#20
Venkat Boddapati, Ridhi Sachdev, Michael C Fu, Christopher L Camp, Robert G Marx, Joshua S Dines
BACKGROUND: Orthopaedic surgeons receive a disproportionately small share of funding from the National Institutes of Health, but they receive the largest amount of funding from industry sources. The purpose of this study was to examine the association between payments from industry partners and research productivity among orthopaedic research authors, as well as to identify predictors of high research productivity. METHODS: United States-based physicians who published an article in 2016 in The Journal of Bone & Joint Surgery or The American Journal of Sports Medicine were included in this study...
March 21, 2018: Journal of Bone and Joint Surgery. American Volume
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