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https://www.readbyqxmd.com/read/28213364/safety-and-antitumor-activity-of-apalutamide-arn-509-in-metastatic-castration-resistant-prostate-cancer-with-and-without-prior-abiraterone-acetate-and-prednisone
#1
Dana E Rathkopf, Emmanuel S Antonarakis, Neal D Shore, Ronald F Tutrone, Joshi J Alumkal, Charles J Ryan, Mansoor Saleh, Ralph J Hauke, Rajesh Bandekar, Edna Chow Maneval, Carla J de Boer, Margaret K Yu, Howard I Scher
PURPOSE: To evaluate the efficacy of apalutamide before or after treatment with abiraterone acetate and prednisone (AAP) in patients with progressive metastatic castration-resistant prostate cancer (mCRPC). EXPERIMENTAL DESIGN: Two cohorts were studied: AAP-naïve and post-AAP patients who had received ≥6 months of AAP. Patients had progressive mCRPC per rising prostate-specific antigen (PSA) and/or imaging, without prior chemotherapy exposure. All received apalutamide 240 mg/day...
February 17, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28212121/identification-and-evaluation-of-clinically-significant-prostate-cancer-a-step-towards-personalized-diagnosis
#2
Adnan Ali, Alexander Hoyle, Esther Baena, Noel W Clarke
PURPOSE OF REVIEW: Prostate cancer (PCa) diagnostics are evolving rapidly. The quest to differentiate 'clinically significant' from 'clinically insignificant' disease has gathered momentum, leading to substantial change in traditional diagnostic approaches. Herein, we review the relevant information on currently available biomarkers and assess their ability to help physicians and patients in making a shared and personalized decision based on their individual risk of harbouring clinically significant disease...
February 16, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28210997/3d-skeletal-uptake-of-18-f-sodium-fluoride-in-pet-ct-images-is-associated-with-overall-survival-in-patients-with-prostate-cancer
#3
Sarah Lindgren Belal, May Sadik, Reza Kaboteh, Nezar Hasani, Olof Enqvist, Linus Svärm, Fredrik Kahl, Jane Simonsen, Mads H Poulsen, Mattias Ohlsson, Poul F Høilund-Carlsen, Lars Edenbrandt, Elin Trägårdh
BACKGROUND: Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases in prostate cancer. We aimed to calculate a 3D index for NaF PET/CT and investigate its correlation to the bone scan index (BSI) and overall survival (OS) in a group of patients with prostate cancer. METHODS: NaF PET/CT and bone scans were studied in 48 patients with prostate cancer...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28209443/continued-benefit-to-rectal-separation-for-prostate-radiation-therapy-final-results-of%C3%A2-a%C3%A2-phase-iii-trial
#4
Daniel A Hamstra, Neil Mariados, John Sylvester, Dhiren Shah, Lawrence Karsh, Richard Hudes, David Beyer, Steven Kurtzman, Jeffrey Bogart, R Alex Hsi, Michael Kos, Rodney Ellis, Mark Logsdon, Shawn Zimberg, Kevin Forsythe, Hong Zhang, Edward Soffen, Patrick Francke, Constantine Mantz, Peter Rossi, Theodore DeWeese, Stephanie Daignault-Newton, Benjamin W Fischer-Valuck, Anupama Chundury, Hiram Gay, Walter Bosch, Jeff Michalski
PURPOSE: SpaceOAR, a Food and Drug Administration-approved hydrogel intended to create a rectal-prostate space, was evaluated in a single-blind phase III trial of image guided intensity modulated radiation therapy. A total of 222 men were randomized 2:1 to the spacer or control group and received 79.2 Gy in 1.8-Gy fractions to the prostate with or without the seminal vesicles. The present study reports the final results with a median follow-up period of 3 years. METHODS AND MATERIALS: Cumulative (Common Terminology Criteria for Adverse Events, version 4...
December 23, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28207981/a-multiparametric-magnetic-resonance-imaging-based-risk-model-to-determine-the-risk-of-significant-prostate-cancer-prior-to-biopsy
#5
Pim J van Leeuwen, Andrew Hayen, James E Thompson, Daniel Moses, Ron Shnier, Maret Böhm, Magdaline Abuodha, Anne-Maree Haynes, Francis Ting, Jelle Barentsz, Monique Roobol, Justin Vass, Krishan Rasiah, Warick Delprado, Phillip D Stricker
OBJECTIVES: To develop and externally validate a predictive model for detection of significant prostate cancer (PC). SUBJECTS AND METHODS: Development of the model was based on prospective cohort including 393 men who underwent mpMRI prior to biopsy. External validity of the model was then examined retrospectively in 198 men from a separate institution whom underwent a mpMRI followed by biopsy for abnormal PSA/DRE. A model was developed with age, PSA, DRE, prostate volume, previous biopsy and PIRADS score as predictors for significant PC (Gleason 7 with >5% grade 4, ≥ 20% cores positive or ≥ 7mm of PC in any core)...
February 16, 2017: BJU International
https://www.readbyqxmd.com/read/28207388/segmentation-of-pathological-structures-by-landmark-assisted-deformable-models
#6
Bulat Ibragimov, Robert Korez, Bostjan Likar, Franjo Pernus, Lei Xing, Tomaz Vrtovec
Computerized segmentation of pathological structures in medical images is challenging, as, in addition to unclear image boundaries, image artifacts and traces of surgical activities, the shape of pathological structures may be very different from the shape of normal structures. Even if a sufficient number of pathological training samples are collected, statistical shape modeling cannot always capture shape features of pathological samples as they may be suppressed by shape features of a considerably larger number of healthy samples...
February 13, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28199367/evaluation-of-different-mathematical-models-and-different-b-value-ranges-of-diffusion-weighted-imaging-in-peripheral-zone-prostate-cancer-detection-using-b-value-up-to-4500-s-mm2
#7
Zhaoyan Feng, Xiangde Min, Daniel J A Margolis, Caohui Duan, Yuping Chen, Vivek Kumar Sah, Nabin Chaudhary, Basen Li, Zan Ke, Peipei Zhang, Liang Wang
OBJECTIVES: To evaluate the diagnostic performance of different mathematical models and different b-value ranges of diffusion-weighted imaging (DWI) in peripheral zone prostate cancer (PZ PCa) detection. METHODS: Fifty-six patients with histologically proven PZ PCa who underwent DWI-magnetic resonance imaging (MRI) using 21 b-values (0-4500 s/mm2) were included. The mean signal intensities of the regions of interest (ROIs) placed in benign PZs and cancerous tissues on DWI images were fitted using mono-exponential, bi-exponential, stretched-exponential, and kurtosis models...
2017: PloS One
https://www.readbyqxmd.com/read/28199041/feasibility-of-accelerated-simultaneous-multislice-diffusion-weighted-mri-of-the-prostate
#8
Jakob Weiss, Petros Martirosian, Jana Taron, Ahmed E Othman, Thomas Kuestner, Michael Erb, Jens Bedke, Fabian Bamberg, Konstantin Nikolaou, Mike Notohamiprodjo
PURPOSE: To assess the feasibility of simultaneous multislice (SMS) single-shot echo-planar-imaging (EPI) for accelerated diffusion-weighted imaging (DWI) of the prostate. MATERIALS AND METHODS: For phantom measurements a dedicated DWI phantom with different sucrose concentrations was used. In addition, 10 volunteers and 16 patients with suspected prostate cancer were examined for in vivo measurements. All examinations were performed with a 3T magnetic resonance imaging (MRI) system...
February 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28197764/new-frontiers-in-prostate-cancer-imaging-clinical-utility-of-prostate-specific-membrane-antigen-positron-emission-tomography
#9
REVIEW
Asim Afaq, Deepak Batura, Jamshed Bomanji
Prostate-specific membrane antigen positron emission tomography (PSMA PET) is a relatively new method of imaging prostate cancer that increases diagnostic accuracy in detecting and guiding management in various stages of the disease pathway. Gallium-68-labelled PSMA PET has increased the sensitivity of detection of disease recurrence at low PSA levels, thus allowing an optimal window for salvage treatment. Apart from its use in disease recurrence, PSMA PET has the potential for increasing sensitivity and specificity for primary tumour localisation and in detecting lymph node disease, leading to a more accurate initial staging of the condition...
February 14, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28197655/prefraction-displacement-and-intrafraction-drift-of-the-prostate-due%C3%A2-to-perineal-ultrasound-probe-pressure
#10
Minglun Li, Nina-Sophie Hegemann, Farkhad Manapov, Anne Kolberg, Patrick Dominik Thum, Ute Ganswindt, Claus Belka, Hendrik Ballhausen
OBJECTIVE: In image-guided EBRT of the prostate, transperineal ultrasound (US) probes exert pressure on the perineum both during planning and treatment. Through tissue deformation and relaxation, this causes target and risk organ displacement and drift. In this study, prefraction shift and intrafraction drift of the prostate are quantified during robotic transperineal 4DUS. METHODS: The position of the prostate was recorded for different positions of the probe before treatment in 10 patients (16 series of measurements)...
February 14, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28197024/nanotechnology-in-urology
#11
REVIEW
Sudhindra Jayasimha
INTRODUCTION: Nanotechnology has revolutionized our approach to medical diagnostics as well as therapeutics and has spanned an entirely new branch of research. This review addresses the potential applications of Nanotechnology in Urology. This article is based on the Dr. Sitharaman Best Essay award of the Urological Society of India for 2016. METHODS: A PubMed search was performed for all relevant articles using the terms, "nanotechnology, nanoparticles, nanoshells, nanoscaffolds, and nanofibers...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28196759/follow-up-mr-imaging-of-pi-rads-3-and-pi-rads-4-prostate-lesions
#12
Elke Hauth, Horst Jaeger, Horst Hohmuth, Meinrad Beer
OBJECTIVE: To determine the rate of malignancy after follow-up MR imaging of the prostate in PI-RADS 3 lesions without core biopsy and PI-RADS 4 lesions after negative initial core biopsy. MATERIALS AND METHODS: We performed follow-up MRI in 46/72 (64%) patients with PI-RADS 3 lesions and 26/72 (36%) patients with PI-RADS 4 lesions in baseline MRI. RESULTS: The rate of malignancy in PI-RADS 3 lesions was 4% (2/46) and in PI-RADS 4 lesions 69% (18/26)...
January 30, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28196723/diagnostic-performance-of-prostate-imaging-reporting-and-data-system-version-2-for-detection-of-prostate-cancer-a-systematic-review-and-diagnostic-meta-analysis
#13
REVIEW
Sungmin Woo, Chong Hyun Suh, Sang Youn Kim, Jeong Yeon Cho, Seung Hyup Kim
CONTEXT: In 2015, the updated Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) for the detection of prostate cancer (PCa) was established. Since then, several studies assessing the value of PI-RADSv2 have been published. OBJECTIVE: To review the diagnostic performance of PI-RADSv2 for the detection of PCa. EVIDENCE ACQUISITION: MEDLINE and EMBASE databases were searched up to December 7, 2016. We included diagnostic accuracy studies that used PI-RADSv2 for PCa detection, using prostatectomy or biopsy as the reference standard...
February 11, 2017: European Urology
https://www.readbyqxmd.com/read/28196288/clinical-adequacy-assessment-of-auto-contours-for-prostate-imrt-with-meaningful-endpoints
#14
Hamidreza Nourzadeh, William T Watkins, Mahmoud Ahmad, Cheukkai Hui, David Schlesinger, Jeffrey V Siebers
PURPOSE: To determine if radiation treatment plans created based on auto-segmented (AS) regions-of-interest (ROI)s are clinically equivalent to plans created based on manually segmented ROIs, where equivalence is evaluated using probabilistic dosimetric metrics and probabilistic biological endpoints for prostate IMRT. METHOD AND MATERIALS: Manually drawn contours and auto-segmented ROIs were created for 167 CT image sets acquired from 19 prostate patients. Auto-segmentation was performed utilizing Pinnacle's Smart Probabilistic Image Contouring Engine...
February 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/28193503/clinical-translation-of-a-psma-inhibitor-for-99m-tc-based-spect
#15
Guillermina Ferro-Flores, Myrna Luna-Gutiérrez, Blanca Ocampo-García, Clara Santos-Cuevas, Erika Azorín-Vega, Nallely Jiménez-Mancilla, Emmanuel Orocio-Rodríguez, Jenny Davanzo, Francisco O García-Pérez
BACKGROUND: Prostate-specific membrane antigen (PSMA) is highly over-expressed in advanced prostate cancers. (68)Ga-labeled PSMA inhibitors (iPSMA) are currently used for prostate cancer detection by PET imaging. The availability of simple, efficient and reproducible radiolabeling procedures is essential for developing new SPECT radiopharmaceuticals for clinical translation. The aim of this research was to prepare (99m)Tc-EDDA/HYNIC-Lys(Nal)-Urea-Glu ((99m)Tc-EDDA/HYNIC-iPSMA) obtained from lyophilized kit formulations and evaluate the in vitro and in vivo radiopharmaceutical binding to prostate cancer cells over-expressing PSMA, as well as the (99m)Tc-EDDA/HYNIC-iPSMA normal biodistribution in humans and the preliminary uptake in patients with prostate cancer...
February 3, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28192761/a-comparison-of-bayesian-and-non-linear-regression-methods-for-robust-estimation-of-pharmacokinetics-in-dce-mri-and-how-it-affects-cancer-diagnosis
#16
Nikolaos Dikaios, David Atkinson, Chiara Tudisca, Pierpaolo Purpura, Martin Forster, Hashim Ahmed, Timothy Beale, Mark Emberton, Shonit Punwani
The aim of this work is to compare Bayesian Inference for nonlinear models with commonly used traditional non-linear regression (NR) algorithms for estimating tracer kinetics in Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI). The algorithms are compared in terms of accuracy, and reproducibility under different initialization settings. Further it is investigated how a more robust estimation of tracer kinetics affects cancer diagnosis. The derived tracer kinetics from the Bayesian algorithm were validated against traditional NR algorithms (i...
February 5, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/28192614/cone-beam-ct-based-adaptive-planning-improves-permanent-prostate-brachytherapy-dosimetry-an-analysis-of-1266-patients
#17
Hendrik Westendorp, Carel J Hoekstra, Jos J Immerzeel, Sandrine M G van de Pol, Charles G H J Niël, Robert A J Kattevilder, Tonnis T Nuver, André W Minken, Marinus A Moerland
PURPOSE: To evaluate adaptive planning for permanent prostate brachytherapy and to identify the prostate regions that needed adaptation. METHODS AND MATERIALS: After the implantation of stranded seeds, using real-time intraoperative planning, a transrectal ultrasound (TRUS)-scan was obtained and contoured. The positions of seeds were determined on a C-arm cone-beam Computed Tomography (CBCT)-scan. The CBCT-scan was registered to the TRUS-scan using fiducial gold markers...
February 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28192308/fluorescence-lifetime-imaging-with-time-gated-detection-of-hyaluronidase-using-a-long-lifetime-azadioxatriangulenium-adota-fluorophore
#18
Rahul Chib, Sebastian Requena, Mark Mummert, Yuri M Strzhemechny, Ignacy Gryczynski, Julian Borejdo, Zygmunt Gryczynski, Rafal Fudala
A fluorescence lifetime imaging probe with a long lifetime was used in combination with time-gating for the detection of hyaluronidase using hyaluronic acid as the probe template. This probe was developed by heavily labeling hyaluronic acid with long lifetime azadioxatriangulenium fluorophores (ADOTA). We used this probe to image hyaluronidase produced by DU-145 prostate cancer cells.
November 17, 2016: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28190784/intraoperative-factors-associated-with-stranded-source-placement-accuracy-in-low-dose-rate-prostate-brachytherapy
#19
M F Jamaluddin, S Ghosh, M P Waine, M Tavakoli, J Amanie, A D Murtha, D Yee, N Usmani
PURPOSE: The quality of a low-dose rate prostate brachytherapy implant depends on the accurate placement of sources in their planned locations. This study investigates intraoperative factors that potentially contribute to stranded source placement inaccuracy in prostate brachytherapy. METHODS AND MATERIALS: Intraoperative video images of the brachytherapist's hand motions and needle insertions during the implant procedure were acquired for analysis. Using video analysis software, maximum and average needle insertion velocities were determined...
February 10, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28187994/defining-the-value-of-magnetic-resonance-imaging-in-prostate-brachytherapy-using-time-driven-activity-based-costing
#20
Nikhil G Thaker, Peter F Orio, Louis Potters
Magnetic resonance imaging (MRI) simulation and planning for prostate brachytherapy (PBT) may deliver potential clinical benefits but at an unknown cost to the provider and healthcare system. Time-driven activity-based costing (TDABC) is an innovative bottom-up costing tool in healthcare that can be used to measure the actual consumption of resources required over the full cycle of care. TDABC analysis was conducted to compare patient-level costs for an MRI-based versus traditional PBT workflow. TDABC cost was only 1% higher for the MRI-based workflow, and utilization of MRI allowed for cost shifting from other imaging modalities, such as CT and ultrasound, to MRI during the PBT process...
February 7, 2017: Brachytherapy
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