Xianhan Jiang, Weide Zhong, Hai Huang, Huichan He, Funeng Jiang, Yanru Chen, Fei Yue, Jing Zou, Xun Li, Yongzhong He, Pan You, Weiqiang Yang, Yiming Lai, Fen Wang, Leyuan Liu
MAP1S (originally named C19ORF5) is a widely distributed homolog of neuronal-specific MAP1A and MAP1B, and bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation. Mitochondrion-associated protein LRPPRC functions as an inhibitor for autophagy initiation to protect mitochondria from autophagy degradation. MAP1S and LRPPRC interact with each other and may collaboratively regulate autophagy although the underlying mechanism is yet unknown. Previously, we have reported that LRPPRC levels serve as a prognosis marker of patients with prostate adenocarcinomas (PCA), and that patients with high LRPPRC levels survive a shorter period after surgery than those with low levels of LRPPRC...
October 2015: Molecular Carcinogenesis