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https://www.readbyqxmd.com/read/28103579/the-combination-of-early-treatment-response-and-ypt-stage-is-a-novel-metric-to-stage-rectal-cancer-patients-treated-with-neoadjuvant-chemoradiotherapy
#1
Jian Cui, Lin Yang, Lei Guo, Yongfu Shao, Dongfeng Tan, Ni Li, Haizeng Zhang
Rectal cancer patients receiving neoadjuvant chemoradiotherapy (NCRT) are currently classified using the same Tumor-Node-Metastasis staging system as those patients without NCRT. We determined whether the combination of tumor treatment response (TRG) and ypT stage more accurately assesses primary tumors in rectal cancer after NCRT. We analyzed data from 329 rectal cancer patients treated with NCRT followed by radical resection. Cox proportional hazards models were used to evaluate the effects of different staging parameters on disease-free survival (DFS)...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28103489/enhanced-degradation-of-organic-contaminants-in-water-by-peroxydisulfate-coupled-with-bisulfite
#2
Chengdu Qi, Xitao Liu, Yang Li, Chunye Lin, Jun Ma, Xiaowan Li, Huijuan Zhang
In this study, the bisulfite-peroxydisulfate system (S(IV)/PDS) widely used in polymerization was innovatively applied for organic contaminants degradation in water. The addition of S(IV) into PDS system remarkably enhanced the degradation efficiency of bisphenol A (BPA, a frequently detected endocrine disrupting chemical in the environments) from 17.0% to 84.7% within 360 min. The degradation efficiency of BPA in the S(IV)/PDS system followed pseudo-first-order kinetics, with rate constant values ranging from 0...
January 10, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28103270/cold-atmospheric-plasma-created-at-the-tip-of-an-elongated-flexible-capillary-using-low-electric-current-can-slow-the-progression-of-melanoma
#3
Y Binenbaum, G Ben-David, Z Gil, Ya Z Slutsker, M A Ryzhkov, J Felsteiner, Ya E Krasik, J T Cohen
INTRODUCTION: Cold Atmospheric Plasma Jet (CAPJ), with ion temperature close to room temperature, has tremendous potential in biomedical engineering, and can potentially offer a therapeutic option that allows cancer cell elimination without damaging healthy tissue. We developed a hand-held flexible device for the delivery of CAPJ to the treatment site, with a modified high-frequency pulse generator operating at a RMS voltage of <1.2 kV and gas flow in the range 0.3-3 l/min. The aims of our study were to characterize the CAPJ emitted from the device, and to evaluate its efficacy in elimination of cancer cells in-vitro and in-vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28103066/practice-based-evidence-in-community-guide-systematic-reviews
#4
Namita Vaidya, Anilkrishna B Thota, Krista K Proia, Sara Jamieson, Shawna L Mercer, Randy W Elder, Paula Yoon, Rachel Kaufmann, Stephanie Zaza
OBJECTIVES: To assess the relative contributions and quality of practice-based evidence (PBE) and research-based evidence (RBE) in The Guide to Community Preventive Services (The Community Guide). METHODS: We developed operational definitions for PBE and RBE in which the main distinguishing feature was whether allocation of participants to intervention and comparison conditions was under the control of researchers (RBE) or not (PBE). We conceptualized a continuum between RBE and PBE...
January 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28102994/at-a-glance-emergency-department-surveillance-of-thermal-burns-and-scalds-electronic-canadian-hospitals-injury-reporting-and-prevention-program-2013
#5
J Crain, S McFaull, D P Rao, M T Do, W Thompson
INTRODUCTION: Although fatality and hospitalization rates for burns in Canada have declined over time, less serious cases still commonly present to the emergency department (ED). METHODS: The Canadian Hospitals Injury Reporting and Prevention Program (CHIRPP) is an injury and poisoning surveillance system administered by the Public Health Agency of Canada, operating in emergency departments of 17 hospitals. RESULTS: Overall, cases reported in 2013 were scalds and contact burns from hot objects...
January 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28102949/simultaneous-pet-mr-imaging-with-a-radio-frequency-penetrable-pet-insert
#6
Alexander M Grant, Brian J Lee, Chen-Ming Chang, Craig S Levin
PURPOSE: A brain sized radio frequency (RF)-penetrable PET insert has been designed for simultaneous operation with MRI systems. This system takes advantage of electro-optical coupling and battery power to electrically float the PET insert relative to the MRI ground, permitting RF signals to be transmitted through small gaps between the modules that form the PET ring. This design facilitates the use of the built-in body coil for RF transmission and thus could be inserted into any existing MR site wishing to achieve simultaneous PET/MR imaging...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102942/a-platform-independent-method-to-reduce-ct-truncation-artifacts-using-discriminative-dictionary-representations
#7
Yang Chen, Adam Budde, Ke Li, Yinsheng Li, Jiang Hsieh, Guang-Hong Chen
PURPOSE: When the scan field of view (SFOV) of a CT system is not large enough to enclose the entire cross-section of the patient, or the patient needs to be positioned partially outside the SFOV for certain clinical applications, truncation artifacts often appear in the reconstructed CT images. Many truncation artifact correction methods perform extrapolations of the truncated projection data based on certain a priori assumptions. The purpose of this work was to develop a novel CT truncation artifact reduction method that directly operates on DICOM images...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102858/luminescent-immunoprecipitation-system-lips-for-detection-of-autoantibodies-against-atp4a-and-atp4b-subunits-of-gastric-proton-pump-h-k-atpase-in-atrophic-body-gastritis-patients
#8
Edith Lahner, Cristina Brigatti, Ilaria Marzinotto, Marilia Carabotti, Giulia Scalese, Howard W Davidson, Janet M Wenzlau, Emanuele Bosi, Lorenzo Piemonti, Bruno Annibale, Vito Lampasona
OBJECTIVES: Circulating autoantibodies targeting the H+/K+-ATPase proton pump of gastric parietal cells are considered markers of autoimmune gastritis, whose diagnostic accuracy in atrophic body gastritis, the pathological lesion of autoimmune gastritis, remains unknown. This study aimed to assess autoantibodies against ATP4A and ATP4B subunits of parietal cells H+, K+-ATPase in atrophic body gastritis patients and controls. METHODS: One-hundred and four cases with atrophic body gastritis and 205 controls were assessed for serological autoantibodies specific for ATP4A or ATP4B subunits using luminescent immunoprecipitation system (LIPS)...
January 19, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28102533/hospital-incident-command-first-responders-or-receiving-centers
#9
Brian Fletcher, Amanda Knight, Brandy Pockrus, Matthew J Wain, Kathy Lehman-Huskamp
OBJECTIVES: (1) Propose a conceptual model of an alternative hospital incident management system (HIMS) that integrates concepts used by emergency operations centers (EOCs). (2) Compare HIMS to the standard hospital incident command system (HICS) model. DESIGN: A quasi-experimental study was performed. Two identical tabletop incident scenarios were presented, one utilizing HICS and one using HIMS. Participants completed postexercise surveys for each tabletop. Surveys contained both knowledge and satisfaction questions...
April 2016: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28102467/mypod-an-emr-based-tool-that-facilitates-quality-improvement-and-maintenance-of-certification
#10
Loren Berman, Brian Duffy, B Randall Brenn, Charles Vinocur
Maintenance of Certification (MOC) was designed to assess physician competencies including operative case volume and outcomes. This information, if collected consistently and systematically, can be used to facilitate quality improvement. Information automatically extracted from the electronic medical record (EMR) can be used as a prompt to compile these data. We developed an EMR-based program called MyPOD (My Personal Outcomes Data) to track surgical outcomes at our institution. We compared occurrences reported in the first 18 months to those captured in the American College of Surgeons National Surgical Quality Improvement Program-Pediatric (ACS NSQIP-P) over the same time period...
March 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28102239/subcycle-quantum-electrodynamics
#11
C Riek, P Sulzer, M Seeger, A S Moskalenko, G Burkard, D V Seletskiy, A Leitenstorfer
Squeezed states of electromagnetic radiation have quantum fluctuations below those of the vacuum field. They offer a unique resource for quantum information systems and precision metrology, including gravitational wave detectors, which require unprecedented sensitivity. Since the first experiments on this non-classical form of light, quantum analysis has been based on homodyning techniques and photon correlation measurements. These methods currently function in the visible to near-infrared and microwave spectral ranges...
January 18, 2017: Nature
https://www.readbyqxmd.com/read/28101937/methods-of-anorectal-manometry-vary-widely-in-clinical-practice-results-from-an-international-survey
#12
E V Carrington, H Heinrich, C H Knowles, S S Rao, M Fox, S M Scott
BACKGROUND: Ano-rectal manometry (ARM) is the most commonly performed investigation for assessment of anorectal dysfunction. Its use is supported by expert consensus documents and international guidelines. Variation in technology, data acquisition, and analysis affect results and clinical interpretation. This study examined variation in ARM between institutions to establish the status of current practice. METHODS: A 50-item web-based questionnaire assessing analysis and interpretation of ARM was distributed by the International Anorectal Physiology Working Group via societies representing practitioners that perform ARM...
January 18, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28101881/using-a-novel-technology-for-disaster-staff-notification
#13
Stephen C Morris, Janice K Pelley, Steven H Mitchell
Notification of backup staff and determining their ability to augment frontline staff is a major component of any disaster plan. However, the communication and organization of this effort has many challenges. These include communication system overload, the disaster setting, disrupted transportation, and staffing impacts on normal operations. An optimal disaster notification system must have the ability to be modified to include all hazards and the unique environment in which the plan is being made. This article highlights a unique disaster staff notification system using a novel technology, an outside administrator, and a multilayer system of redundant communication...
November 2016: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28101832/serum-uric-acid-levels-contribute-to-new-renal-damage-in-systemic-lupus-erythematosus-patients
#14
C Reátegui-Sokolova, Manuel F Ugarte-Gil, Rocío V Gamboa-Cárdenas, Francisco Zevallos, Jorge M Cucho-Venegas, José L Alfaro-Lozano, Mariela Medina, Zoila Rodriguez-Bellido, Cesar A Pastor-Asurza, Graciela S Alarcón, Risto A Perich-Campos
This study aims to determine whether uric acid levels contribute to new renal damage in systemic lupus erythematosus (SLE) patients. This prospective study was conducted in consecutive patients seen since 2012. Patients had a baseline visit and follow-up visits every 6 months. Patients with ≥2 visits were included; those with end-stage renal disease (regardless of dialysis or transplantation) were excluded. Renal damage was ascertained using the SLICC/ACR damage index (SDI). Univariable and multivariable Cox-regression models were performed to determine the risk of new renal damage...
January 18, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28101725/sustained-release-delivery-system-of-a-slow-hydrogen-sulfide-donor-gyy-4137-for-potential-application-in-glaucoma
#15
A Patil, S Singh, C Opere, A Dash
Hydrogen sulfide (H2S) targets both underlying factors in glaucoma pathogenesis by reducing elevated intraocular pressure (IOP) and providing retinal neuroprotection, whereas the current clinical approaches targets only reducing IOP. Therefore, H2S could be a potential superior candidate for glaucoma pharmacotherapy. However, H2S could be toxic in a concentration greater than 200 μM and its donors are unstable in water. Therefore, this study investigated the preparation and characterization of a non-aqueous in situ gelling sustained-release delivery system for H2S donors...
January 18, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28101675/operative-planning-aid-for-optimal-endoscopic-third-ventriculostomy-entry-points-in-pediatric-cases
#16
Zsolt Zador, David J Coope, Abteen Mostofi, Ian D Kamaly-Asl
OBJECT: Endoscopic third ventriculostomy (ETV) uses anatomical spaces of the ventricular system to reach the third ventricle floor and create an alternative pathway for cerebrospinal fluid flow. Optimal ETV trajectories have been previously proposed in the literature, designed to grant access to the third ventricle floor without a displacement of eloquent periventricular structures. However, in hydrocephalus, there is a significant variability to the configuration of the ventricular system, implying that the optimal ETV trajectory and cranial entry point needs to be planned on a case-by-case basis...
January 18, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28101655/percutaneous-vertebral-augmentation-in-fragility-fractures-indications-and-limitations
#17
O Gonschorek, S Hauck, T Weiß, V Bühren
INTRODUCTION: There is still no general consensus about the management of osteoporotic vertebral fractures. Recommendations depend on type of fracture, grade of instability, bone quality, and general conditions of the patient. Spontaneous fractures may be considered to be treated different compared to cases with high-velocity trauma. METHODS: According to the DVO, patients without trauma should first be treated conservatively. However, there is no more strict time protocol of 3 or 6 week conservative treatment before operations may be indicated...
January 18, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28101421/structural-and-functional-human-retinal-imaging-with-a-fiber-based-visible-light-oct-ophthalmoscope
#18
Shau Poh Chong, Marcel Bernucci, Harsha Radhakrishnan, Vivek J Srinivasan
The design of a multi-functional fiber-based Optical Coherence Tomography (OCT) system for human retinal imaging with < 2 micron axial resolution in tissue is described. A detailed noise characterization of two supercontinuum light sources with different pulse repetition rates is presented. The higher repetition rate and lower noise source is found to enable a sensitivity of 96 dB with 0.15 mW light power at the cornea and a 98 microsecond exposure time. Using a broadband (560 ± 50 nm), 90/10, fused single-mode fiber coupler designed for visible wavelengths, the sample arm is integrated into an ophthalmoscope platform, similar to current clinical OCT systems...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28101405/deep-tissue-photoacoustic-computed-tomography-with-a-fast-and-compact-laser-system
#19
Depeng Wang, Yuehang Wang, Weiran Wang, Dandan Luo, Upendra Chitgupi, Jumin Geng, Yang Zhou, Lidai Wang, Jonathan F Lovell, Jun Xia
Photoacoustic computed tomography (PACT) holds great promise for biomedical imaging, but wide-spread implementation is impeded by the bulkiness of flash-lamp-pumped laser systems, which typically weigh between 50 - 200 kg, require continuous water cooling, and operate at a low repetition rate. Here, we demonstrate that compact lasers based on emerging diode technologies are well-suited for preclinical and clinical PACT. The diode-pumped laser used in this study had a miniature footprint (13 × 14 × 7 cm(3)), weighed only 1...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28101403/quantitative-assessment-of-hemodynamic-and-structural-characteristics-of-in-vivo-brain-tissue-using-total-diffuse-reflectance-spectrum-measured-in-a-non-contact-fashion
#20
Yinchen Song, Sarahy Garcia, Yisel Frometa, Jessica C Ramella-Roman, Mohammad Soltani, Mohamed Almadi, Jorge J Riera, Wei-Chiang Lin
Here we present a new methodology that investigates the intrinsic structural and hemodynamic characteristics of in vivo brain tissue, in a non-contact fashion, and can be easily incorporated in an intra-operative environment. Within this methodology, relative total diffuse reflectance spectra (RTD(λ)) were acquired from targets using a hybrid spectroscopy imaging system. A spectral interpretation algorithm was subsequently applied to RTD(λ) to retrieve optical properties related to the compositional and structural characteristics of each target...
January 1, 2017: Biomedical Optics Express
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