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https://www.readbyqxmd.com/read/29909687/comparative-efficacy-of-autologous-stromal-vascular-fraction-and-autologous-adipose-derived-mesenchymal-stem-cells-combined-with-hyaluronic-acid-for-the-treatment-of-sheep-osteoarthritis
#1
Xiaoteng Lv, Jiyin He, Xue Zhang, Xuan Luo, Na He, Zhongwei Sun, Huitang Xia, Victor Liu, Li Zhang, Xiangming Lin, Liping Lin, Huabin Yin, Dong Jiang, Wei Cao, Richard Wang, Guangdong Zhou, Wen Wang
The current study explored whether intra-articular (IA) injection of autologous adipose mesenchymal stem cells (ASCs) combined with hyaluronic acid (HA) achieved better therapeutic efficacy than autologous stromal vascular fraction (SVF) combined with HA to prevent osteoarthritis (OA) progression and determined how long autologous ASCs combined with HA must remain in the joint to observe efficacy. OA models were established by performing anterior cruciate ligament transection (ACLT) and medial meniscectomy (MM)...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29905752/gga-let-7f-3p-promotes-apoptosis-in-selenium-deficiency-induced-skeletal-muscle-by-targeting-selenoprotein-k
#2
Rui-Feng Fan, Chang-Yu Cao, Meng-Hao Chen, Qun-Xiang Shi, Shi-Wen Xu
Selenoprotein K (SELENOK) is primarily observed in the endoplasmic reticulum, and serves to maintain the normal physiological functions of skeletal muscle. Skeletal muscle development and regeneration are associated with significant changes in the expression of specific microRNAs (miRNAs). Downregulated SELENOK expression is observed in chicken muscles deficient of Se. However, the mechanisms of miRNA regulation of SELENOK expression remain elusive. Here, deep sequencing was used to detect the miRNA profiles of muscle in Se deficient (-Se group) and normal (C group) chickens...
June 15, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29904285/sugammadex-appropriate-use-in-the-context-of-budgetary-constraints
#3
REVIEW
Guy Cammu
Purpose of Review: The purpose of this review is to assess how sugammadex impacts postoperative residual curarization using appropriate doses based on neuromuscular transmission monitoring and whether the advantages of sugammadex versus neostigmine outweigh its higher cost. Recent Findings: An accurate assessment of neuromuscular blockade with monitoring is necessary before selecting neostigmine versus sugammadex for reversal at the end of surgery to overcome incomplete neuromuscular recovery...
2018: Current Anesthesiology Reports
https://www.readbyqxmd.com/read/29891485/electrical-recordings-of-the-mitochondrial-calcium-uniporter-in-xenopus-oocytes
#4
Chen-Wei Tsai, Ming-Feng Tsai
The mitochondrial calcium uniporter is a multisubunit Ca2+ channel that mediates mitochondrial Ca2+ uptake, a cellular process crucial for the regulation of oxidative phosphorylation, intracellular Ca2+ signaling, and apoptosis. In the last few years, genes encoding uniporter proteins have been identified, but a lack of efficient tools for electrophysiological recordings has hindered quantitative analysis required to determine functional mechanisms of this channel complex. Here, we redirected Ca2+ -conducting subunits (MCU and EMRE) of the human uniporter to the plasma membrane of Xenopus oocytes...
June 11, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29890285/m-health-2-0-new-perspectives-on-mobile-health-machine-learning-and-big-data-analytics
#5
Robert S H Istepanian, Turki Al-Anzi
Mobile health (m-Health) has been repeatedly called the biggest technological breakthrough of our modern times. Similarly, the concept of big data in the context of healthcare is considered one of the transformative drivers for intelligent healthcare delivery systems. In recent years, big data has become increasingly synonymous with mobile health, however key challenges of 'Big Data and mobile health', remain largely untackled. This is becoming particularly important with the continued deluge of the structured and unstructured data sets generated on daily basis from the proliferation of mobile health applications within different healthcare systems and products globally...
June 8, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29884513/acquired-antibodies-to-%C3%AE-iib%C3%AE-3-in-glanzmann-thrombasthenia-from-transfusion-and-pregnancy-to-bone-marrow-transplants-and-beyond
#6
REVIEW
Alan T Nurden
Patients with the inherited bleeding disorder Glanzmann thrombasthenia (GT) possess platelets that lack αIIbβ3 integrin and fail to aggregate, and have moderate to severe mucocutaneous bleeding. Many become refractory to platelet transfusions due to the formation of isoantibodies to αIIbβ3 with the rapid elimination of donor platelets and/or a block of function. Epitope characterization has shown isoantibodies to be polyclonal and to recognize different epitopes on the integrin with β3 a major site and αvβ3 on endothelial and vascular cells a newly recognized target...
May 23, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29878472/sleep-disorders-in-the-elderly-a-growing-challenge
#7
REVIEW
Kamalesh K Gulia, Velayudhan Mohan Kumar
In contrast to newborns, who spend 16-20 h in sleep each day, adults need only about sleep daily. However, many elderly may struggle to obtain those 8 h in one block. In addition to changes in sleep duration, sleep patterns change as age progresses. Like the physical changes that occur during old age, an alteration in sleep pattern is also a part of the normal ageing process. As people age, they tend to have a harder time falling asleep and more trouble staying asleep. Older people spend more time in the lighter stages of sleep than in deep sleep...
May 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/29871734/lactoferrin-prevents-susceptibility-of-wehi-231-cells-to-anti-ig-induced-cell-death-promoting-cell-differentiation
#8
E Zaczyńska, I Kochanowska, M Kruzel, M Zimecki
Immature B cells are susceptible to apoptosis due to ligation of surface immunoglobulin receptors. The WEHI 231 cell line represents a useful model to study the mode of action of factors preventing apoptosis. In this work we investigated the protective effects of multi-species lactoferrins in anti-mouse Ig-induced WEHI 231 cell death. Bovine milk-derived lactoferrin (bLF), recombinant human lactoferrin expressed in Chinese hamster ovary cells - rhLF(CHO) or in human endothelial kidney cells - rhLF(HEK), and recombinant mouse lactoferrin expressed in Chinese hamster ovary cells - rmLF(CHO), were used...
2018: Folia Biologica (Praha)
https://www.readbyqxmd.com/read/29863600/clinical-evaluation-of-a-multiparametric-deep-learning-model-for-glioblastoma-segmentation-using-heterogeneous-magnetic-resonance-imaging-data-from-clinical-routine
#9
Michael Perkuhn, Pantelis Stavrinou, Frank Thiele, Georgy Shakirin, Manoj Mohan, Dionysios Garmpis, Christoph Kabbasch, Jan Borggrefe
OBJECTIVES: The aims of this study were, first, to evaluate a deep learning-based, automatic glioblastoma (GB) tumor segmentation algorithm on clinical routine data from multiple centers and compare the results to a ground truth, manual expert segmentation, and second, to evaluate the quality of the segmentation results across heterogeneous acquisition protocols of routinely acquired clinical magnetic resonance imaging (MRI) examinations from multiple centers. MATERIALS AND METHODS: The data consisted of preoperative MRI scans (T1, T2, FLAIR, and contrast-enhanced [CE] T1) of 64 patients with an initial diagnosis of primary GB, which were acquired in 15 institutions with varying protocols...
May 31, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29862290/are-janus-kinase-inhibitors-superior-over-classic-biologic-agents-in-ra-patients
#10
REVIEW
Przemyslaw J Kotyla
The Janus Kinases (JAKs) are a family of intracellular tyrosine kinases that provide transmission signals from cytokine, interferons, and many hormones receptors to the nucleus resulting in synthesis of many biologically active compounds and changing cell metabolism and function. That was theoretical background to synthetize the JAK inhibitors (Jakinibs). In recent years a substantial battery of evidence has been collected indicating the potential role of Jakinibs to interact with the specific elements of the immune system, therefore changing the inflammatory response...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29850760/hierarchically-organized-honeycomb-films-through-block-copolymer-directed-self-assembly-in-breath-figure-templating-and-soft-microwave-triggered-annealing
#11
Nicolas Benoot, Pierre Marcasuzaa, Laurence Pessoni, Sirikorn Chasvised, Stéphanie Reynaud, Antoine Bousquet, Laurent Billon
Hierarchically organized polymer films are produced with a high level of order from the combination of block copolymer nanophase segregation, "breath figure" methodology and microwave irradiation. A block copolymer based on poly(methyl methacrylate) and poly(n-butylacrylate) featuring cylindrical nanopatterns is involved in the "breath figure" process to create a microporous honeycomb structure. These films are submitted to microwave annealing to enhance the degree of ordering of the nano-segregation without the destruction of the honeycomb microstructure, which is not possible by classical thermal or solvent annealing...
May 31, 2018: Soft Matter
https://www.readbyqxmd.com/read/29849062/calcium-sequestration-by-fungal-melanin-inhibits-calcium-calmodulin-signalling-to-prevent-lc3-associated-phagocytosis
#12
Irene Kyrmizi, Helena Ferreira, Agostinho Carvalho, Julio Alberto Landero Figueroa, Pavlos Zarmpas, Cristina Cunha, Tonia Akoumianaki, Kostas Stylianou, George S Deepe, George Samonis, João F Lacerda, António Campos, Dimitrios P Kontoyiannis, Nikolaos Mihalopoulos, Kyung J Kwon-Chung, Jamel El-Benna, Isabel Valsecchi, Anne Beauvais, Axel A Brakhage, Nuno M Neves, Jean-Paul Latge, Georgios Chamilos
LC3-associated phagocytosis (LAP) is a non-canonical autophagy pathway regulated by Rubicon, with an emerging role in immune homeostasis and antifungal host defence. Aspergillus cell wall melanin protects conidia (spores) from killing by phagocytes and promotes pathogenicity through blocking nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent activation of LAP. However, the signalling regulating LAP upstream of Rubicon and the mechanism of melanin-induced inhibition of this pathway remain incompletely understood...
May 30, 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29803933/progress-in-the-development-of-nanosensitizers-for-x-ray-induced-photodynamic-therapy
#13
Xu-Dong Ren, Xiu-Yun Hao, Hong-Cai Li, Mei-Rong Ke, Bi-Yuan Zheng, Jian-Dong Huang
In recent years, photodynamic therapy has been applied in cancer treatment because of its high selectivity and marginal invasion properties. However, the excitation light used has limited ability to penetrate tissue, which creates a stumbling block for its future development. To overcome this, X-rays have been introduced to transmit energy to deeper tissues. Given that a large number of X-ray-induced sensitizers have been designed to facilitate X-ray excitation and generate reactive oxygen species (ROS), this has led to the concept of X-ray-induced photodynamic therapy (X-PDT)...
May 24, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29803571/clipping-of-a-pediatric-pial-arteriovenous-fistula-located-at-basilar-artery-tip-using-a-hybrid-trapping-evacuation-technique
#14
Jingwei Li, Zeng Gao, Xinglong Zhi, Jianxin Du, Hongqi Zhang, Feng Ling
Intracranial pial arteriovenous fistulas (PAVFs) are rare cerebrovascular lesions causing high mortality rates. The authors report a rare case of pediatric PAVF presented at basilar artery tip and its treatment with surgical clipping aided by trapping-evacuation technique in a hybrid operation room. An 18 months old boy was admitted due to hypoevolutismus and weakness of left extremities for 4 months. Magnetic resonance imaging revealed a giant aneurysm-like malformation in the area of midbrain and pons...
May 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29802410/effect-of-multiple-cyclic-rgd-peptides-on-tumor-accumulation-and-intratumoral-distribution-of-irdye-700dx-conjugated-polymers
#15
Xuebo Dou, Takahiro Nomoto, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
Strategic delivery of IRDye 700DX (photosensitizer) is a key for improving its effect in photodynamic therapy. In this study, we have synthesized IRDye 700DX-conjugated polymers containing multiple cyclic RGD peptides to deliver IRDye 700DX selectively to tumor cells and tumor-associated blood vessels overexpressing αv β3 integrin. Our polymer has a backbone of hydrophilic poly(ethylene glycol)-poly(L-glutamic acid) block copolymer, and cyclic RGD peptides are conjugated to side chains of the poly(L-glutamic acid) while IRDye 700DX is conjugated to the terminal of poly(ethylene glycol)...
May 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29800050/swallowing-kinematic-differences-across-frozen-mixed-and-ultrathin-liquid-boluses-in-healthy-adults-age-sex-and-normal-variability
#16
Ianessa A Humbert, Kirstyn L Sunday, Eleni Karagiorgos, Alicia K Vose, Francois Gould, Lindsey Greene, Ara Tolar, Alycia Rivet
Purpose: The aim of this study was to examine the effects of frozen and mixed-consistency boluses on the swallowing physiology of younger and older adults. We also aimed to quantify factors that lead to increased variability in swallowing outcomes (i.e., age, sex, bolus type). Method: Forty-one healthy adults (18-85 years old) swallowed 5 blocks of 5 different boluses: 10-ml ultrathin liquid, a teaspoon of iced barium, a teaspoon of room-temperature pudding, a teaspoon of frozen pudding, and ultrathin barium with chocolate chips...
May 23, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29794801/combined-superficial-and-deep-serratus-plane-block-with-bupivacaine-dexamethasone-and-clonidine-in-the-treatment-of-a-patient-with-postmastectomy-pain-syndrome-a-case-report
#17
Christopher J Maranto, Natalie R Strickland, Johnathan H Goree
Postmastectomy pain syndrome poses a significant treatment challenge. We present the case of a 42-year-old woman who presented to our pain clinic with a 16-month history of postmastectomy pain. We performed a combined superficial and deep serratus plane block using bupivacaine, dexamethasone, and clonidine. At 1-month follow-up, the patient had 100% pain relief. At 2-month follow-up, her pain was 5/10. The block was repeated with the same drugs at 3 months with similar pain relief. This case illustrates the utility of a combined superficial and deep serratus plane block in postmastectomy pain syndrome with a possible benefit from added dexamethasone and clonidine...
May 23, 2018: A&A practice
https://www.readbyqxmd.com/read/29793153/effects-of-mg-2-on-recovery-of-nmda-receptors-from-inhibition-by-memantine-and-ketamine-reveal-properties-of-a-second-site
#18
Nathan G Glasgow, Madeleine R Wilcox, Jon W Johnson
Memantine and ketamine are NMDA receptor (NMDAR) open channel blockers that are thought to act via similar mechanisms at NMDARs, but exhibit divergent clinical effects. Both drugs act by entering open NMDARs and binding at a site deep within the ion channel (the deep site) at which the endogenous NMDAR channel blocker Mg2+ also binds. Under physiological conditions, Mg2+ increases the IC50 s of memantine and ketamine through competition for binding at the deep site. Memantine also can inhibit NMDARs after associating with a second site accessible in the absence of agonist, a process termed second site inhibition (SSI) that is not observed with ketamine...
May 12, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29793013/may-thurner-syndrome-presenting-as-acute-unexplained-dvt
#19
Zulfiqar Qutrio Baloch, Muhammad Hussain, Muhammad Ayyaz, Nishant Dagli, Shabber Agha Abbas
May-Thurner syndrome (MTS) is a rare cause of deep venous thrombosis (DVT) and occurs due to an anatomic anomaly which produces chronic compression of the left common iliac vein by the overlying right common iliac artery when it passes between the right common iliac artery and the spine. Prolonged compression on the vein potentiates thrombus formation by impairing the intima and by leading to the development of membranes within the lumen that may decrease and/or block venous flow. In this case presentation, we elaborate upon a case of a 43-year-old woman who presented with worsening left leg swelling and pain...
May 21, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29792848/subthalamic-nucleus-deep-brain-stimulation-protects-neurons-by-activating-autophagy-via-pp2a-inactivation-in-a-rat-model-of-parkinson-s-disease
#20
Ting-Ting Du, Ying-Chuan Chen, Yong-Quan Lu, Fan-Gang Meng, Hui Yang, Jian-Guo Zhang
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapeutic strategy for alleviating disability in patients with moderate to severe Parkinson's disease (PD). Preclinical studies have shown that stimulation of the rat STN can protect against nigral dopaminergic neuron loss. However, the underlying mechanism is unclear. To investigate the molecular basis of the neuroprotective effects of STN stimulation, a rat model of PD was established by unilaterally injecting 6-hydroxydopamine (6-OHDA) into the striatum...
May 21, 2018: Experimental Neurology
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