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Intracoronary imaging

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https://www.readbyqxmd.com/read/27904523/the-role-of-near-infrared-spectroscopy-in-the-detection-of-vulnerable-atherosclerotic-plaques
#1
Martin Horvath, Petr Hajek, Cyril Stechovsky, Jakub Honek, Miloslav Spacek, Josef Veselka
Coronary artery disease is the leading cause of mortality worldwide. Most acute coronary syndromes are caused by a rupture of a vulnerable atherosclerotic plaque which can be characterized by a lipid-rich necrotic core with an overlying thin fibrous cap. Many vulnerable plaques can cause angiographically mild stenoses due to positive remodelling, which is why the extent of coronary artery disease may be seriously underestimated. In recent years, we have witnessed a paradigm shift in interventional cardiology...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27904032/coronary-microvascular-dysfunction%C3%A3-epidemiology-pathogenesis-prognosis-diagnosis-risk-factors-and-therapy
#2
Cheng Chen, Janet Wei, Ahmed AlBadri, Parham Zarrini, C Noel Bairey Merz
Angina has traditionally been thought to be caused by obstructive coronary artery disease (CAD). However, a substantial number of patients with angina are found to not have obstructive CAD when undergoing coronary angiography. A significant proportion of these patients have coronary microvascular dysfunction (CMD), characterized by heightened sensitivity to vasoconstrictor stimuli and limited microvascular vasodilator capacity. With the advent of non-invasive and invasive techniques, the coronary microvasculature has been more extensively studied in the past 2 decades...
November 29, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27894949/intravascular-hemodynamics-and-coronary-artery-disease-new-insights-and-clinical-implications
#3
REVIEW
Marina Zaromytidou, Gerasimos Siasos, Ahmet U Coskun, Michelle Lucier, Antonios P Antoniadis, Michail I Papafaklis, Konstantinos C Koskinas, Yannis Andreou, Charles L Feldman, Peter H Stone
Understanding of the pathophysiological mechanisms is the cornerstone of preventive and treatment strategies in the battle against coronary artery disease. Hyperlipidemia, arterial hypertension, smoking and diabetes, are established risk factors affecting coronary vasculature. However, the focal formation of atherosclerotic lesions in certain arterial regions underscores that local factors are implicated in the initiation and progression of atherosclerosis. Introduction of novel imaging modalities and technological advances offered new insights and acknowledged intravascular hemodynamics, and particularly flow-derived endothelial shear stress as a critical factor in the natural history of coronary artery disease...
November 25, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27832796/antecedent-hypertension-and-myocardial-injury-in-patients-with-reperfused-st-elevation-myocardial-infarction
#4
Sebastian J Reinstadler, Thomas Stiermaier, Charlotte Eitel, Mohammed Saad, Bernhard Metzler, Suzanne de Waha, Georg Fuernau, Steffen Desch, Holger Thiele, Ingo Eitel
BACKGROUND: Antecedent hypertension is associated with poor outcome in patients with ST-elevation myocardial infarction (STEMI). Whether differences in myocardial salvage, infarct size and microvascular injury contribute to the adverse outcome is unknown. We investigated the association between antecedent hypertension and cardiovascular magnetic resonance (CMR) parameters of myocardial salvage and damage in a multicenter CMR substudy of the AIDA-STEMI trial (Abciximab Intracoronary versus intravenously Drug Application in ST-elevation myocardial infarction)...
November 11, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27830336/optical-coherence-tomography-influence-of-contrast-concentration-on-image-quality-and-diagnostic-confidence
#5
Florian Blachutzik, Stephan Achenbach, Holger Nef, Christian Hamm, Oliver Dörr, Niklas Boeder, Mohamed Marwan, Monique Tröbs, Reinhard Schneider, Jens Röther, Christian Schlundt
OCT requires intracoronary injection of contrast agent to remove blood from the coronary lumen during data acquisition, which is a possible limitation of this method. Aim of this study was to analyze the influence of iodine concentration on image quality and diagnostic certainty of optical coherence tomography (OCT). OCT sequences acquired using contrast agent with a reduced concentration of 150 mg iodine/ml and a standard concentration of 350 mg iodine/ml were analyzed. Cross-sectional images with a spacing of 10 mm were evaluated regarding image quality and diagnostic confidence...
November 9, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27806897/comparison-of-an-everolimus-eluting-bioresorbable-scaffold-with-an-everolimus-eluting-metallic-stent-for-the-treatment-of-coronary-artery-stenosis-absorb-ii-a-3-year-randomised-controlled-single-blind-multicentre-clinical-trial
#6
Patrick W Serruys, Bernard Chevalier, Yohei Sotomi, Angel Cequier, Didier Carrié, Jan J Piek, Ad J Van Boven, Marcello Dominici, Dariusz Dudek, Dougal McClean, Steffen Helqvist, Michael Haude, Sebastian Reith, Manuel de Sousa Almeida, Gianluca Campo, Andrés Iñiguez, Manel Sabaté, Stephan Windecker, Yoshinobu Onuma
BACKGROUND: No medium-term data are available on the random comparison between everolimus-eluting bioresorbable vascular scaffolds and everolimus-eluting metallic stents. The study aims to demonstrate two mechanistic properties of the bioresorbable scaffold: increase in luminal dimensions as a result of recovered vasomotion of the scaffolded vessel. METHODS: The ABSORB II trial is a prospective, randomised, active-controlled, single-blind, parallel two-group, multicentre clinical trial...
November 19, 2016: Lancet
https://www.readbyqxmd.com/read/27790824/an-exploratory-randomized-control-study-of-combination-cytokine-and-adult-autologous-bone-marrow-progenitor-cell-administration-in-patients-with-ischaemic-cardiomyopathy-the-regenerate-ihd-clinical-trial
#7
Tawfiq Choudhury, Abdul Mozid, Steve Hamshere, Chia Yeo, Cyril Pellaton, Samer Arnous, Natalie Saunders, Pat Brookman, Ajay Jain, Didier Locca, Andrew Archbold, Charles Knight, Andrew Wragg, Ceri Davies, Peter Mills, Mahesh Parmar, Martin Rothman, Fizzah Choudry, Daniel A Jones, Samir Agrawal, John Martin, Anthony Mathur
AIMS: The effect of combined cytokine and cell therapy in ischaemic cardiomyopathy is unknown. Meta-analyses suggest improved cardiac function with cell therapy. The optimal cell delivery route remains unclear. We investigated whether granulocyte colony-stimulating factor (G-CSF) alone or in combination with intracoronary (i.c.) or intramyocardial (i.m.) injection of autologous bone marrow-derived cells (BMCs) improves cardiac function. METHODS AND RESULTS: Ninety patients with symptomatic ischaemic cardiomyopathy and no further treatment options were enrolled in the randomized, placebo-controlled, single-centre REGENERATE-IHD study...
October 28, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27782708/computer-aided-detection-of-intracoronary-stent-in-intravascular-ultrasound-sequences
#8
Francesco Ciompi, Simone Balocco, Juan Rigla, Xavier Carrillo, Josepa Mauri, Petia Radeva
PURPOSE: An intraluminal coronary stent is a metal mesh tube deployed in a stenotic artery during percutaneous coronary intervention (PCI), in order to prevent acute vessel occlusion. The identification of struts location and the definition of the stent shape is relevant for PCI planning and for patient follow-up. The authors present a fully automatic framework for computer-aided detection (CAD) of intracoronary stents in intravascular ultrasound (IVUS) image sequences. The CAD system is able to detect stent struts and estimate the stent shape...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27773862/possible-mechanical-causes-of-scaffold-thrombosis-insights-from-case-reports-with-intracoronary-imaging
#9
Yohei Sotomi, Pannipa Suwannasom, Patrick W Serruys, Yoshinobu Onuma
The advent of intracoronary stents greatly increased the safety and applicability of percutaneous coronary interventions. One of the drawbacks of drug eluting stents (DES) is the increased risk of late and very late stent thrombosis (ST). The risk of ST after the DES implantation were anticipated to be solved with the advent of fully biodegradable scaffolds which offers the possibility of transient scaffolding of the vessel to prevent acute vessel closure and recoil while also transiently eluting an antiproliferative drug to counteract the constrictive remodeling and excessive neointimal hyperplasia...
October 25, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27764157/long-term-outcome-of-combined-percutaneous-intramyocardial-and-intracoronary-application-of-autologous-bone-marrow-mononuclear-cells-post-myocardial-infarction-the-5-year-mystar-study
#10
Mariann Gyöngyösi, Georgiana-Aura Giurgea, Bonni Syeda, Silvia Charwat, Beatrice Marzluf, Julia Mascherbauer, Andras Jakab, Abelina Zimba, Márta Sárközy, Noemi Pavo, Heinz Sochor, Senta Graf, Irene Lang, Gerald Maurer, Jutta Bergler-Klein
OBJECTIVE: The long-term (5-year) outcome of early (3-6 weeks after acute myocardial infarction [AMI], BM-MNC Early group) and late (3-4 months after AMI, BM-MNC Late group) combined (percutaneous intramyocardial and intracoronary) delivery of autologous bone marrow mononuclear cells (BM-MNCs) was evaluated in patients with ejection fractions (EF) between 30-45% post-AMI. METHODS: Major adverse cardiac and cerebrovascular events (MACCE) and hospitalization were recorded...
2016: PloS One
https://www.readbyqxmd.com/read/27743950/coronary-atherosclerosis-t1-weighed-characterization-with-integrated-anatomical-reference-comparison-with-high-risk-plaque%C3%A2-features-detected-by-invasive-coronary-imaging
#11
Yibin Xie, Young-Jin Kim, Jianing Pang, Jung-Sun Kim, Qi Yang, Janet Wei, Christopher T Nguyen, Zixin Deng, Byoung Wook Choi, Zhaoyang Fan, C Noel Bairey Merz, Prediman K Shah, Daniel S Berman, Hyuk-Jae Chang, Debiao Li
OBJECTIVES: The aim of this work is the development of coronary atherosclerosis T1-weighted characterization with integrated anatomical reference (CATCH) technique and the validation by comparison with high-risk plaque features (HRPF) observed on intracoronary optical coherence tomography (OCT) and invasive coronary angiography. BACKGROUND: T1-weighted cardiac magnetic resonance with or without contrast media has been used for characterizing coronary atherosclerosis showing promising prognostic value...
October 6, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27743816/neoatherosclerosis-causing-occlusive-in-stent-restenosis-impact-of-intracoronary-imaging-in-the-intensity-of-lipid-lowering-therapy
#12
David Martí, Edurne López, Salvador Álvarez, Jorge Palazuelos, Ignacio Rada, Fernando Alfonso
The unique physical properties of optical coherence tomography (OCT) make it a useful technique in the study of restenosis mechanisms. In fact, OCT is able to differentiate between neointimal proliferation and neoatherosclerosis within the stent. We report a rare case of occlusive neoatherosclerosis presenting beyond one year after a successful drug-eluting stent implantation. The impact of OCT findings in the clinical decision making process is emphasized.
September 30, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27736028/effect-of-intravenous-and-intracoronary-melatonin-as-an-adjunct-to-primary-percutaneous-coronary-intervention-for-acute-st-elevation-myocardial-infarction-results-of-the-melatonin-adjunct-in-the-acute-myocardial-infarction-treated-with-angioplasty-maria-trial
#13
Alberto Dominguez-Rodriguez, Pedro Abreu-Gonzalez, Jose M de la Torre-Hernandez, Julia Gonzalez-Gonzalez, Tamara Garcia-Camarero, Luciano Consuegra-Sanchez, Maria Del Mar Garcia-Saiz, Ana Aldea-Perona, Tirso Virgos-Aller, Agueda Azpeitia, Russel J Reiter
The MARIA randomized trial evaluated the efficacy and safety of melatonin for the reduction of reperfusion injury in patients undergoing revascularization for ST-elevation myocardial infarction (STEMI). This was a prespecified interim analysis. A total of 146 patients presenting with STEMI within 6 hours of chest pain onset were randomized to receive intravenous and intracoronary melatonin (n=73) or placebo (n=73) during primary pecutaneous coronary intervention (PPCI). Primary endpoint was myocardial infarct size as assessed by magnetic resonance imaging (MRI) at 6±2 days...
October 13, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27724910/hemodynamic-numerical-simulations-of-the-disturbance-due-to-intracoronary-flow-measurements-by-a-doppler-guide-wire
#14
Kamil J Chodzyński, Simone Gremmo, Omer F Eker, Jacques Lalmand, Adel Aminian, Daniel Ribeiro de Sousa, Karim Zouaoui Boudjeltia, Grégory Coussement
BACKGROUND: Since hemodynamics plays a key role in the development and evolution of cardiovascular pathologies, physician's decision must be based on proper monitoring of relevant physiological flow quantities. METHODS: A numerical analysis of the error introduced by an intravascular Doppler guide wire on the peak velocity measurements has been carried out. The effect of probe misalignment (±10°) with respect to the vessel axis was investigated. Numerical simulations were performed on a realistic 3D geometry, reconstructed from coronary angiography images...
October 10, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/27717579/ivus-and-oct-guided-primary-percutaneous-coronary-intervention-for-spontaneous-coronary-artery-dissection-with-bioresorbable-vascular-scaffolds
#15
Muhammad Muzaffar Mahmood, David Austin
Spontaneous coronary artery dissection (SCAD) is an uncommon but important cause of acute coronary syndrome. The diagnosis of SCAD by an angiogram alone can be challenging and the increasing use of intracoronary imaging has proven an invaluable diagnostic adjunct in this regard. The appropriate initial management of SCAD has been a matter of significant debate. Owing to frequent spontaneous healing of coronary dissection and a higher risk of complications with percutaneous coronary intervention (PCI) in the setting of SCAD, a default approach of mechanical revascularization is not recommended...
September 18, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27677883/exosomes-secreted-by-cardiosphere-derived-cells-reduce-scarring-attenuate-adverse-remodelling-and-improve-function-in-acute-and-chronic-porcine-myocardial-infarction
#16
Romain Gallet, James Dawkins, Jackelyn Valle, Eli Simsolo, Geoffrey de Couto, Ryan Middleton, Eleni Tseliou, Daniel Luthringer, Michelle Kreke, Rachel R Smith, Linda Marbán, Bijan Ghaleh, Eduardo Marbán
AIMS: Naturally secreted nanovesicles known as exosomes are required for the regenerative effects of cardiosphere-derived cells (CDCs), and exosomes mimic the benefits of CDCs in rodents. Nevertheless, exosomes have not been studied in a translationally realistic large-animal model. We sought to optimize delivery and assess the efficacy of CDC-secreted exosomes in pig models of acute (AMI) and convalescent myocardial infarction (CMI). METHODS AND RESULTS: In AMI, pigs received human CDC exosomes (or vehicle) by intracoronary (IC) or open-chest intramyocardial (IM) delivery 30 min after reperfusion...
September 27, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27667384/forty-years-of-chest-pain-a-case-report-and-contemporary-review-of-the-diagnostic-and-therapeutic-options-for-myocardial-bridging
#17
Emily Tat, Richard Cheng, Jeffrey S Helfenstein
A 48-year-old woman with 40 years of intermittent squeezing chest pain presented with worsening symptoms. Results of an ambulatory electrocardiogram, echocardiogram, and exercise treadmill were unremarkable. Persistent symptoms prompted a computed tomography coronary angiogram (CTCA) that revealed mid-left anterior descending artery myocardial bridging (MB) that was not physiologically significant by exercise single-photon emission CT. Conservative treatment was pursued. Anatomic MB is prevalent in a large proportion of the general population and are increasingly identified by CTCA...
2016: Reviews in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27639737/the-optis-integrated-system-real-time-co-registration-of-angiography-and-optical-coherence-tomography
#18
Johannes N van der Sijde, Giulio Guagliumi, Vasile Sirbu, Kunihiro Shimamura, Marco Borghesi, Antonios Karanasos, Evelyn Regar
The efficacy of an IVUS-guided stent implantation strategy to improve acute results and clinical outcome has been described previously. OCT is another technique which allows high-resolution intracoronary imaging. However, the use of invasive imaging modalities to guide PCI has, as yet, played a limited role in current clinical practice. This may be partly explained by the expertise required for interpretation and clinical decision making. We present a novel technology which enables real-time co-registration of OCT images with angiography...
September 18, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27626971/association-between-coronary-microvascular-function-and-the-vasa-vasorum-in-patients-with-early-coronary-artery-disease
#19
Kyoung-Ha Park, Tao Sun, Felipe Diez-Delhoyo, Zhi Liu, Shi-Wei Yang, Ryan J Lennon, Joerg Herrmann, Rajiv Gulati, Martin Rodriguez-Porcel, Lilach O Lerman, Amir Lerman
BACKGROUND AND AIMS: The vasa vasorum (VV) plays a role in the initial phase of atherosclerosis, and abnormalities in microvascular function may be sensitive measures of the early development of atherosclerosis. The current study was designed to access the association between coronary microvascular function and VV density in patients undergoing cardiac catheterization. METHODS: Twenty-four patients with early coronary artery disease underwent endothelium-dependent (coronary blood flow, CBF) and endothelium-independent (coronary flow velocity reserve, CFVR) coronary microvascular function testing, and optical coherence tomography (OCT) imaging of the left anterior descending coronary artery (LAD)...
October 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27592277/accuracy-of-area-at-risk-quantification-by-cardiac-magnetic-resonance-according-to-the-myocardial-infarction-territory
#20
Leticia Fernández-Friera, José Manuel García-Ruiz, Ana García-Álvarez, Rodrigo Fernández-Jiménez, Javier Sánchez-González, Xavier Rossello, Sandra Gómez-Talavera, Gonzalo J López-Martín, Gonzalo Pizarro, Valentín Fuster, Borja Ibáñez
INTRODUCTION AND OBJECTIVES: Area at risk (AAR) quantification is important to evaluate the efficacy of cardioprotective therapies. However, postinfarction AAR assessment could be influenced by the infarcted coronary territory. Our aim was to determine the accuracy of T2-weighted short tau triple-inversion recovery (T2W-STIR) cardiac magnetic resonance (CMR) imaging for accurate AAR quantification in anterior, lateral, and inferior myocardial infarctions. METHODS: Acute reperfused myocardial infarction was experimentally induced in 12 pigs, with 40-minute occlusion of the left anterior descending (n = 4), left circumflex (n = 4), and right coronary arteries (n = 4)...
August 31, 2016: Revista Española de Cardiología
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