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https://www.readbyqxmd.com/read/28634393/a-small-molecule-ds44170716-inhibits-ca-2-induced-mitochondrial-permeability-transition
#1
Naohiro Kon, Atsushi Satoh, Naoki Miyoshi
Mitochondria are involved in a variety of physiological and pathological processes. Ca(2+) uptake is one of the important functions of the organelle for maintenance of cellular Ca(2+) homeostasis. In pathological conditions such as ischemia reperfusion injury, Ca(2+) overload into mitochondria induces mitochondrial permeability transition (MPT), a critical step for cell death. Because inhibition of MPT is a promising approach to protecting cells and organs, it is important for drug discovery to identify novel chemicals or mechanisms to inhibit MPT...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634097/acetabular-reconstruction-with-the-medial-protrusio-technique-for-complex-primary-and-revision-total-hip-arthroplasties
#2
Scott M Eskildsen, Zenus J Wilson, David C McNabb, Christopher W Olcott, Daniel J Del Gaizo
BACKGROUND: In the setting of acetabular deficiency during total hip arthroplasty (THA), the medial protrusio technique (MPT) allows for increased component coverage while avoiding excessive component abduction or elevation of the hip center. The technique involves controlled reaming through the medial acetabular wall while maintaining the continuity of the anterior and posterior columns. The purpose of this study is to analyze the results of the largest reported series to date of primary and revision THAs using the MPT...
May 26, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28631679/-the-comparative-assessment-of-the-vocal-function-in-the-professional-voice-users-and-non-occupational-voice-users-in-the-late-adulthood
#3
O G Pavlikhin, S G Romanenko, D I Krasnikova, E V Lesogorova, V S Yakovlev
The objective of the present study was to evaluate the clinical and functional condition of the voice apparatus in the elderly patients and to elaborate recommendations for the prevention of disturbances of the vocal function in the professional voice users. This comprehensive study involved 95 patients including the active professional voice users (n=48) and 45 non-occupational voice users at the age from 61 to 82 years with the employment history varying from 32 to 51 years. The study was designed to obtain the voice characteristics by means of the subjective auditory assessment, microlaryngoscopy, video laryngostroboscopy, determination of maximum phonation time (MPT), and computer-assisted acoustic analysis of the voice with the use of the MDVP Kay Pentaxy system...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28631113/fast-determination-of-ingredients-in-solid-pharmaceuticals-by-microwave-enhanced-in-source-decay-of-microwave-plasma-torch-mass-spectrometry
#4
Rui Su, Xinchen Wang, Changming Hou, Meiling Yang, Keke Huang, Huanwen Chen
Rapid qualitative and quantitative analysis of solid samples (e.g., pharmaceutical preparations) by using a small and low-resolution mass spectrometer without MS/MS function is still a challenge in ambient pressure ionization mass spectrometric analysis. Herein, a practically efficient method termed microwave-enhanced in-source decay (MEISD) using microwave plasma torch desorption ionization coupled with time-of-flight mass spectrometry (MPTDI-TOF MS) was developed for fast analysis of pharmaceutical tablets using a miniature TOF mass spectrometer without tandem mass function...
June 19, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28630580/the-effect-of-upper-body-anaerobic-pre-loading-on-2000-m-ergometer-rowing-performance-in-college-level-male-rowers
#5
Priit Purge, Peter Hofmann, Rait Merisaar, Alexander Mueller, Gerhard Tschakert, Jarek Mäestu, Jaak Jürimäe
Elevated blood lactate has been shown to influence subsequent anaerobic exercise due to an inhibition of glycolysis. The aim of the present study was therefore to investigate the influence of a short and high-intensity anaerobic arm crank pre-load exercise (HIE) added to a low-intensity warm-up on cardio-respiratory and metabolic responses on a subsequent all out rowing exercise. Nine well-trained college level male rowers (24.6 ± 7.1 yrs; 1.87 ± 0.07 m; 88.9 ± 9.8 kg; 18.5 ± 3.7% body fat) volunteered to participate in the study...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28628730/comparative-study-on-ambient-ionization-methods-for-direct-analysis-of-navel-orange-tissues-by-mass-spectrometry
#6
H Zhang, A Bibi, H Lu, J Han, H Chen
It is of sustainable interest to improve the sensitivity and selectivity of the ionization process, especially for direct analysis of complex samples without matrix separation. Herein, four ambient ionization methods including desorption atmospheric pressure chemical ionization (DAPCI), heat-assisted desorption atmospheric pressure chemical ionization (heat-assisted DAPCI), microwave plasma torch (MPT), and internal extractive electrospray ionization (iEESI) were employed for comparative analysis of the navel orange tissue samples by mass spectrometry...
June 19, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28624490/bioenergetics-dysfunction-mitochondrial-permeability-transition-pore-opening-and-lipid-peroxidation-induced-by-hydrogen-sulfide-as-relevant-pathomechanisms-underlying-the-neurological-dysfunction-characteristic-of-ethylmalonic-encephalopathy
#7
Gabriela Miranda Fernandez Cardoso, Julia Tauana Pletsch, Belisa Parmeggiani, Mateus Grings, Nícolas Manzke Glanzel, Larissa Daniele Bobermin, Alexandre Umpierrez Amaral, Moacir Wajner, Guilhian Leipnitz
Hydrogen sulfide (sulfide) accumulates at high levels in the brains of patients with ethylmalonic encephalopathy (EE). In the present study, we evaluated whether sulfide could disturb energy and redox homeostasis, and induce mitochondrial permeability transition (mPT) pore opening in rat brain aiming to better clarify the neuropathophysiology of EE. Sulfide decreased the activities of citrate synthase and aconitase in rat cerebral cortex mitochondria, and of creatine kinase (CK) in rat cerebral cortex, striatum and hippocampus supernatants...
June 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28606663/changes-after-voice-therapy-in-acoustic-voice-analysis-of-chinese-patients-with-voice-disorders
#8
Dan Lu, Fei Chen, Hui Yang, Rong Yu, Qi Zhou, Xinyuan Zhang, Jia Ren, Yitao Zheng, Xiaoyan Zhang, Jian Zou, Haiyang Wang, Jun Liu
OBJECTIVES: This study aimed to evaluate the effects of voice therapy on patients with voice disorders by comparing the acoustic parameter changes before and after treatment. STUDY DESIGN: This is a retrospective study. METHODS: Forty-five female patients with early-stage vocal nodules or polyps, postoperative patients, and patients with chronic laryngitis were divided into three subgroups. Videostroboscopic, acoustic analysis (fundamental frequency, jitter, shimmer, mean harmonics-to-noise ratio), and maximum phonation time (MPT) were measured before and after treatment...
June 9, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28602826/an-alternative-didactic-functional-and-topographic-systematization-of-the-spinal-muscles
#9
Vivianne Izabelle de Araújo Baptista, William Paganini Mayer, Ricardo Eustáquio da Silva, Ricardo Bragança de Vasconcellos Fontes, Josemberg da Silva Baptista
Back muscles are commonly described in a topographically-oriented manner without necessarily following morphological criteria. In this manner, non-standard terms may be employed which convey incorrect morphological concepts and demanding more time from both faculty and students to transmit knowledge. We propose a classification system for spinal muscles incorporating morphological concepts with the goal of facilitating knowledge transfer and suggest the term "spinal muscles". Paraspinal muscles were systematically divided and classified in seven strata from anterior to posterior: vertebro-appendicular (VA), transversarium (Tr), deep post-transversarium (DPT), middle post-transversarium (MPT), superficial post-transversarium (SPT), deep spino-appendicular (DSA) and superficial spino-appendicular (SSA)...
June 7, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28600625/an-intravaginal-ring-that-releases-three-antiviral-agents-and-a-contraceptive-blocks-shiv-rt-infection-reduces-hsv-2-shedding-and-suppresses-hormonal-cycling-in-rhesus-macaques
#10
Nina Derby, Meropi Aravantinou, Jessica Kenney, Shweta R Ugaonkar, Asa Wesenberg, Jolanta Wilk, Larisa Kizima, Aixa Rodriguez, Shimin Zhang, Olga Mizenina, Keith Levendosky, Michael L Cooney, Samantha Seidor, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Michael Piatak, Jeffrey D Lifson, José Fernández-Romero, Thomas M Zydowsky, Melissa Robbiani
Women globally need access to multipurpose prevention technologies (MPTs) that prevent human immunodeficiency virus (HIV), sexually transmitted infections that increase HIV acquisition/transmission risk, and unintended pregnancy. Seeking an MPT with activity against HIV, herpes simplex virus-2 (HSV-2), and human papillomavirus (HPV), we developed a prototype intravaginal ring (IVR), the MZCL IVR, which released the antiviral agents MIV-150, zinc acetate, and carrageenan (MZC for short) and the contraceptive levonorgestrel (LNG)...
June 9, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28580597/false-fmri-activation-after-motion-correction
#11
Renat Yakupov, Juan Lei, Michael Hoffmann, Oliver Speck
Motion correction of echo-planar imaging (EPI) data used in functional MRI (fMRI) is an essential preprocessing step performed prior to statistical analysis. At ultra-high resolution fMRI, current requirements regarding translational and rotational motion may no longer be acceptable. This prompts the need for a systematic investigation of the effects of motion correction procedures with in vivo fMRI data. Here we systematically evaluated the effect of retrospective motion correction with freely available fMRI analysis software packages (FSL, AFNI, and SPM) on activation maps using fMRI data acquired with prospective motion detection, to identify and quantify confounding effects of retrospective motion correction, and to evaluate its dependence on spatial resolution and motion correction algorithms...
June 5, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28566520/mitochondrial-permeability-transition-involves-dissociation-of-f1fo-atp-synthase-dimers-and-c-ring-conformation
#12
Massimo Bonora, Claudia Morganti, Giampaolo Morciano, Gaia Pedriali, Magdalena Lebiedzinska-Arciszewska, Giorgio Aquila, Carlotta Giorgi, Paola Rizzo, Gianluca Campo, Roberto Ferrari, Guido Kroemer, Mariusz R Wieckowski, Lorenzo Galluzzi, Paolo Pinton
The impact of the mitochondrial permeability transition (MPT) on cellular physiology is well characterized. In contrast, the composition and mode of action of the permeability transition pore complex (PTPC), the supramolecular entity that initiates MPT, remain to be elucidated. Specifically, the precise contribution of the mitochondrial F1FO ATP synthase (or subunits thereof) to MPT is a matter of debate. We demonstrate that F1FO ATP synthase dimers dissociate as the PTPC opens upon MPT induction. Stabilizing F1FO ATP synthase dimers by genetic approaches inhibits PTPC opening and MPT Specific mutations in the F1FO ATP synthase c subunit that alter C-ring conformation sensitize cells to MPT induction, which can be reverted by stabilizing F1FO ATP synthase dimers...
May 31, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28552641/pcramoll-and-rcramoll-lectins-induce-cell-death-in-human-prostate-adenocarcinoma-pc-3-cells-by-impairment-of-mitochondrial-homeostasis
#13
Evellyne de Oliveira Figueirôa, Mary Ângela Aranda-Souza, Nathalia Varejão, Franco Aparecido Rossato, Rute Alves Pereira Costa, Tiago Rezende Figueira, Luís Cláudio Nascimento da Silva, Roger Frigério Castilho, Aníbal Eugênio Vercesi, Maria Tereza Dos Santos Correia
Lectins from Cratylia mollis seed have shown potential in vivo antitumor actions, however the mechanism have not yet been addressed. Here we evaluated the antitumor effects of native (pCramoll) and recombinant (rCramoll) lectins from C. mollis against human prostate adenocarcinoma (PC-3) cells. The viability of PC-3 cells was analyzed with the MTT assay and ANNEXIN V/propidium iodide staining. The actions of pCramoll or rCramoll on mitochondrial superoxide production, free cytosolic calcium concentration and mitochondrial membrane potential were evaluated using fluorescent probes (MitoSox Red, Fura 2-AM and safranin O, respectively)...
May 25, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28551548/quantitative-evaluation-of-atherosclerotic-plaques-and-intraplaque-neovascularization-using-contrast-enhanced-ultrasound-after-treatment-with-atorvastatin-in-rabbits
#14
Hong-Yu Liu, Jia Zhou, Hai Tong, Yan Tang, Xiao-Fang Wang, Qi-Chang Zhou
INTRODUCTION: This study is supposed to investigate the value of contrast-enhanced ultrasound (CEUS) in quantitative evaluation of atherosclerotic plaques and intraplaque neovascularization after treatment with atorvastatin (ATV) in rabbits. MATERIAL AND METHODS: Forty-five New Zealand white rabbits were enrolled to construct the rabbit model of AS. All rabbits were assigned into the control, AS group and ATV groups (n=15 individually). The AS plaque formation and relative parameters were observed and calculated by CEUS respectively...
May 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28548150/using-%C3%AE-2-rheology-to-quantify-rheological-properties-during-repeated-reversible-phase-transitions-of-soft-matter
#15
Matthew D Wehrman, Melissa J Milstrey, Seth Lindberg, Kelly M Schultz
A microfluidic device is designed to measure repeated phase transitions, gelation and degradation, on a single sample by exchanging the surrounding fluid while minimizing shear stress. This device enables quantitative microrheological characterization of material properties over multiple phase transitions, determining whether the material returns to the same equilibrium state. Fluid exchange is accomplished by using a two layer design, the sample is trapped in the first layer and the second layer is a well for the exchanging fluid...
June 13, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28545946/body-mass-index-and-acoustic-voice-parameters-is-there-a-relationship
#16
Lourdes Bernadete Rocha de Souza, Marquiony Marques Dos Santos
INTRODUCTION: Specific elements such as weight and body volume can interfere in voice production and consequently in its acoustic parameters, which is why it is important for the clinician to be aware of these relationships. OBJECTIVE: To investigate the relationship between body mass index (BMI) and the average acoustic voice parameters. METHODS: Observational, cross-sectional descriptive study. The sample consisted of 84 women, aged between 18 and 40years, an average of 26...
May 6, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28539339/mif-2-d-dt-enhances-proximal-tubular-cell-regeneration-through-slpi-and-atf4-dependent-mechanisms
#17
Akinobu Ochi, Dong Chen, Wibke Schulte, Lin Leng, Nickolas Gilbert Moeckel, Marta Piecychna, Luisa Averdunk, Christian Stoppe, Richard Bucala, Gilbert W Moeckel
Macrophage migration inhibitory factor (MIF) is a cytokine with pleiotropic actions that is produced by several organs and cell types. Depending on the target cell and the inflammatory context, MIF can engage its two component receptor complex CD74 and CD44, and the chemokine receptors CXCR2/4. MIF is constitutively expressed in renal proximal tubular cells, stored in intracellular preformed pools and is released at a low rate. Recently a second MIF-like protein (i.e. MIF-2/D-DT) has been characterized in mammals...
May 24, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28536722/apixaban-pharmacodynamic-activity-in-umbilical-cord-paediatric-and-adult-plasma
#18
Robert J Yetman, Yu Chen Barrett, Zhaoqing Wang, Robert Adamczyk, Jessie Wang, Eduardo Ramacciotti, Charles Frost
The objective was to characterise apixaban pharmacodynamic (PD) activity in umbilical cord (UC), paediatric, and adult plasma. Plasma was obtained from blood samples from six UC donors, 70 paediatric (neonates [birth-≤1 month], infants [>1-≤6 months], toddlers [>6 months-≤2 years], young children [>2-≤6 years], children [>6-≤12 years], adolescents [>12-≤18 years]), and six adult (19-45 years) subjects. Plasma spiked with apixaban 0 (baseline), 30, or 110 ng/ml was analysed for anti-factor Xa activity, factor X levels, prothrombin time (PT), and modified PT (mPT)...
May 24, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28530217/-phonosurgical-methods-of-treatment-in-unilateral-vocal-folds-paralysis
#19
REVIEW
Bozena Kosztyła-Hojna, Greta Berger, Maciej Zdrojkowski
Glottal insufficiency (GI) is a cause of breathy voice that can profoundly affect quality of voice. Main causes are unilateral vocal fold paralysis or endoscopic cordectomy for the early treatment of laryngeal cancer of the glottis. The main strategy in surgical treatment is type I medialization thyroplasty according to Isshiki with the use of implants e.g. silastic, hydroxyapatite, titanium, Gore-Tex or Montgomery. Other procedures are arytenoid adduction, the injection laryngoplasty via thyrohyoid and cricothyroid approach and laryngeal reinnervation...
April 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28526197/towards-a-quantitative-indicator-of-feather-disruption-following-the-cleansing-of-oiled-birds
#20
Stephen W Bigger, Lawrence N Ngeh, Peter Dann, John D Orbell
A computer-based imaging method for determining feather microstructure coherency following a cleansing treatment, was developed, calibrated and trialled on Mallard Duck (Anas platyrhyhchos) feathers. The feathers were initially contaminated with a light crude oil and then cleansed by either detergent (Deacon 90) treatment or, alternatively, by magnetic particle technology (MPT) using iron powder. The imaging method provides a single quantitative parameter for the coherence of feather microstructure and the results confirm that MPT treatment imparts less disruption to the feather microstructure than detergent treatment...
May 16, 2017: Marine Pollution Bulletin
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