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https://www.readbyqxmd.com/read/28791483/influence-of-season-age-and-management-on-scrotal-thermal-profile-in-murrah-bulls-using-scrotal-infrared-digital-thermography
#1
Maneesh Kumar Ahirwar, Mukund Amritrao Kataktalware, Kerekoppa Puttaiah Ramesha, Heartwin Amaladhas Pushpadass, Sakthivel Jeyakumar, Deginal Revanasiddu, Reen Jagish Kour, Sapna Nath, Anand Kumar Nagaleekar, Sayyad Nazar
The aim of the present study was to examine the effects of non-genetic factors on scrotal thermographic profile viz., proximal pole temperature (PPT °C), mid pole temperature (MPT °C), distal pole temperature (DPT °C) and ocular temperature (OcT) of Murrah (Bubalus bubalis) breeding bulls. A total of 109 buffalo bulls, maintained at three semen stations (SS), were monitored for scrotal surface and ocular temperatures using infrared thermography twice daily during rainy, winter and summer seasons using an FLIR i5 infrared camera and temperatures were measured...
August 9, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28791468/functional-outcomes-of-endoscopic-arytenoid-abduction-lateropexy-for-unilateral-vocal-cord-paralysis-with-dyspnea
#2
Vera Matievics, Adam Bach, Balazs Sztano, Zsofia Bere, Zoltan Tobias, Paul F Castellanos, Andreas H Mueller, Laszló Rovo
In unilateral vocal cord paralysis (UVCP), hoarseness is usually the leading symptom; however, the diminished airway might lead to breathing problems as well, especially with exertion. The application of the classic resection glottis enlarging or medialization procedures might shift the breathing and/or the voice to a worse condition. The non-destructive endoscopic arytenoid abduction lateropexy (EAAL) might be a solution for this problem. The aim of our study was to analyze the phonatory and respiratory outcomes of this treatment concept...
August 8, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28768445/single-walled-carbon-nanotube-multi-walled-carbon-nanotube-and-fe2o3-nanoparticles-induced-mitochondria-mediated-apoptosis-in-melanoma-cells
#3
Parvaneh Naserzadeh, Fatemeh Ansari Esfeh, Mahboubeh Kaviani, Khadigeh Ashtari, Raheleh Kheirbakhsh, Ahmad Salimi, Jalal Pourahmad
PURPOSE: Nanomaterials (NM) exhibit novel anticancer properties. MATERIALS AND METHODS: The toxicity of three nanoparticles that are currently being produced in high tonnage including single-walled carbon nanotube (SWCNT), multi-walled carbon nanotube (MWCNT) and Fe2O3 nanoparticles, were compared with normal and melanoma cells. RESULTS: All tested nanoparticles induced selective toxicity and caspase 3 activation through mitochondria pathway in melanoma cells and mitochondria cause the generating of reactive oxygen species (ROS), mitochondrial membrane potential decline (MMP collapse), mitochondria swelling and cytochrome c release...
August 2, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28761525/the-minipterional-approach-for-ruptured-and-unruptured-anterior-circulation-aneurysms-our-initial-experience
#4
Kenan A Alkhalili, Jack R Hannallah, Gasser H Alshyal, Mohab M Nageeb, Khaled M Abdel Aziz
OBJECTIVE: To report our experience with the minipterional (MPT) craniotomy approach for anterior circulation aneurysms and to discuss the clinical outcomes as well as to evaluate the advantages of this unique approach. MATERIALS AND METHODS: Single-center retrospective review of 57 cases involving anterior circulation aneurysms both ruptured and unruptured aneurysms treated with the MPT. We analyzed the clinical and patient demographic data, aneurysm characteristics, surgical outcomes, and complications in these individuals...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28758933/flexible-mixed-potential-type-mpt-no%C3%A2-sensor-based-on-an-ultra-thin-ceramic-film
#5
Rui You, Gaoshan Jing, Hongyan Yu, Tianhong Cui
A novel flexible mixed-potential-type (MPT) sensor was designed and fabricated for NO₂ detection from 0 to 500 ppm at 200 °C. An ultra-thin Y₂O₃-doped ZrO₂ (YSZ) ceramic film 20 µm thick was sandwiched between a heating electrode and reference/sensing electrodes. The heating electrode was fabricated by a conventional lift-off process, while the porous reference and the sensing electrodes were fabricated by a two-step patterning method using shadow masks. The sensor's sensitivity is achieved as 58...
July 29, 2017: Sensors
https://www.readbyqxmd.com/read/28755383/solid-bone-tumors-of-the-spine-diagnostic-performance-of-apparent-diffusion-coefficient-measured-using-diffusion-weighted-mri-using-histology-as-a-reference-standard
#6
Grazia Pozzi, Domenico Albano, Carmelo Messina, Salvatore Alessio Angileri, Asma'a Al-Mnayyis, Fabio Galbusera, Alessandro Luzzati, Giuseppe Perrucchini, Gennaro Scotto, Antonina Parafioriti, Alberto Zerbi, Luca Maria Sconfienza
PURPOSE: To assess the diagnostic performance of mean apparent diffusion coefficient (mADC) in differentiating benign from malignant bone spine tumors, using histology as a reference standard. Conventional magnetic resonance imaging (MRI) sequences have good reliability in evaluating spinal bone tumors, although some features of benign and malignant cancers may overlap, making the differential diagnosis challenging. MATERIALS AND METHODS: In all, 116 patients (62 males, 54 females; mean age 59...
July 29, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28748471/evaluation-of-mitochondrial-respiration-in-cultured-rat-hepatocytes
#7
Jean-Pierre Marchandeau, Gilles Labbe
Mitochondrial dysfunction is a major mechanism whereby drugs can induce liver injury and other serious side effects, such as lactic acidosis and rhabdomyolysis, in some patients. Several in vitro and in vivo investigations can be performed in order to determine if drugs can disturb mitochondrial fatty acid oxidation (FAO) and the oxidative phosphorylation (OXPHOS) process, deplete hepatic mitochondrial DNA (mtDNA), or trigger the opening of the mitochondrial permeability transition pore (MPT). Among these investigations, mitochondrial respiration is a relatively easy test to measure the potential toxicity of a drug...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28745019/identifying-cancer-drug-regimens-in-french-health-insurance-database-an-application-in-multiple-myeloma-patients
#8
Aurore Palmaro, Martin Gauthier, Fabien Despas, Maryse Lapeyre-Mestre
PURPOSE: There is no consensus on how to handle complex drug combinations of cancer drugs through medico-administrative databases. Our objective was to develop an algorithm for identifying the nature and patterns of treatment lines in a cohort of newly treated multiple myeloma patients. METHODS: A cohort of multiple myeloma patients starting a first treatment line was built using both ambulatory and hospital data from regional data of the French national healthcare system database (SNIIRAM)...
July 25, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28739332/effects-of-voice-therapy-on-muscle-tension-dysphonia-a-systematic-literature-review
#9
REVIEW
Gabriela da Cunha Pereira, Isadora de Oliveira Lemos, Camila Dalbosco Gadenz, Mauriceia Cassol
The present study aimed to carry out a systematic review of the effects of voice therapy on individuals diagnosed with muscle tension dysphonia (MTD) or hyperfunctional dysphonia. This is a systematic literature review on the databases Medline (via PubMed), Cochrane Library, Scopus, and Lilacs using a search strategy related to the theme of the study. The selection included clinical trials that assessed the effects of speech therapy intervention on patients diagnosed with MTD or hyperfunctional dysphonia published over the last 10 years in Portuguese, English, or Spanish...
July 21, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28733813/individual-and-combined-effects-of-cannabis-and-tobacco-on-drug-reward-processing-in-non-dependent-users
#10
Chandni Hindocha, Will Lawn, Tom P Freeman, H Valerie Curran
RATIONALE: Cannabis and tobacco are often smoked simultaneously in joints, and this practice may increase the risks of developing tobacco and/or cannabis use disorders. Currently, there is no human experimental research on how these drugs interact on addiction-related measures. OBJECTIVES: This study aimed to investigate how cannabis and tobacco, each alone and combined together in joints, affected individuals' demand for cannabis puffs and cigarettes, explicit liking of drug and non-drug-related stimuli and craving...
July 22, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28710466/dramatic-increases-in-blood-glutamate-concentrations-are-closely-related-to-traumatic-brain-injury-induced-acute-lung-injury
#11
Wei Bai, Wan-Li Zhu, Ya-Lei Ning, Ping Li, Yan Zhao, Nan Yang, Xing Chen, Yu-Lin Jiang, Wen-Qun Yang, Dong-Po Jiang, Li-Yong Chen, Yuan-Guo Zhou
Traumatic brain injury-induced acute lung injury (TBI-ALI) is a serious complication after brain injury for which predictive factors are lacking. In this study, we found significantly elevated blood glutamate concentrations in patients with TBI or multiple peripheral trauma (MPT), and patients with more severe injuries showed higher blood glutamate concentrations and longer durations of elevated levels. Although the increase in amplitude was similar between the two groups, the duration was longer in the patients with TBI...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28702111/innate-function-of-house-dust-mite-allergens-robust-enzymatic-degradation-of-extracellular-matrix-at-elevated-ph
#12
Kumiko Oida, Lukas Einhorn, Ina Herrmann, Lucia Panakova, Yvonne Resch, Susanne Vrtala, Gerlinde Hofstetter, Akane Tanaka, Hiroshi Matsuda, Erika Jensen-Jarolim
BACKGROUND: Exposure to the house dust mite Dermatophagoides pteronyssinus (D.p.) increases the risk for developing allergic diseases in humans and their best friends, the dogs. Here, we explored whether this allergenic mite via its enzymes may impact the cutaneous extracellular matrix (ECM), which critically determines epithelial barrier integrity both structurally and functionally. METHODS: Two extracts obtained from either dust-purified or cultured D.p. bodies were used in the present study...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28686664/somatosensory-function-in-patients-with-secondary-adrenal-insufficiency-treated-with-two-different-doses-of-hydrocortisone-results-from-a-randomized-controlled-trial
#13
Jorien Werumeus Buning, Karl-Heinz Konopka, Pauline Brummelman, Janneke Koerts, Robin P F Dullaart, Gerrit van den Berg, Melanie M van der Klauw, Oliver Tucha, Bruce H R Wolffenbuttel, André P van Beek
BACKGROUND: Low cortisol levels are associated with several functional pain syndromes. In patients with secondary adrenal insufficiency (SAI), the lack in endogenous cortisol production is substituted by the administration of oral hydrocortisone (HC). Our previous study showed that a lower dose of HC led to an increase in reported subjective pain symptoms. Whether different doses of HC substitution alter somatosensory functioning in SAI patients has not been established yet. METHODS: In this randomized double blind cross-over trial, forty-six patients with SAI participated...
2017: PloS One
https://www.readbyqxmd.com/read/28681824/levels-of-circulating-immune-complexes-containing-mycobacterium-tuberculosis-specific-antigens-in-pulmonary-tuberculosis-and-sarcoidosis-patients
#14
B Goyal, J A Sheikh, R Agarwal, I Verma
The present study was conducted to understand the aetiological link between tuberculosis (TB) and sarcoidosis. Sera from smear-positive TB subjects (n = 24), smear-negative TB subjects (n = 24), sarcoidosis patients (n = 24) and healthy controls (n = 24) were collected and circulating immune complexes were isolated. Sandwich ELISA was performed for detecting four highly specific mycobacterial regions of difference (RD) proteins (early secretory antigenic target 6 [ESAT6], 10 KDa culture filtrate protein [CFP10], 21 KDa CFP [CFP21] and mycobacterial protein from species TB [MPT 64])...
April 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28672691/the-relationship-between-the-length-of-surface-ligand-and-effects-of-cdte-quantum-dots-on-the-physiological-functions-of-isolated-mitochondria
#15
Xun Xiang, Can Wu, Bo-Rui Zhang, Tao Gao, Jie Zhao, Long Ma, Feng-Lei Jiang, Yi Liu
The potential toxicity of Quantum dots (QDs) should be assessed comprehensively for their fast spreading applications. Many studies have shown the toxicity of QDs is associated with their surface ligands. In this work, two analog ligands with one carbon difference, 2-mercaptoacetic acid (TGA) and 3-mercaptopropionic acid (MPA) were used as coating materials in the syntheses of two types of CdTe QDs with similar physicochemical properties. Then the biological effects of QDs on isolated mitochondria were studied...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28670625/mechanisms-of-acetaminophen-hepatotoxicity-and-their-translation-to-the-human-pathophysiology
#16
Anup Ramachandran, Hartmut Jaeschke
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States and mechanisms of liver injury induced by APAP overdose have been the focus of extensive investigation. Studies in the mouse model, which closely reproduces the human condition, have shown that hepatotoxicity is initiated by formation of a reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI), which depletes cellular glutathione and forms protein adducts on mitochondrial proteins. This leads to mitochondrial oxidative and nitrosative stress, accompanied by activation of c-jun N-terminal kinase (JNK) and its translocation to the mitochondria...
February 2017: Journal of Clinical and Translational Research
https://www.readbyqxmd.com/read/28668862/clinicopathological-characteristics-of-metaplastic-papillary-tumor-of-the-fallopian-tube
#17
M I Jang, Ji-Youn Sung, Ji-Ye Kim, Hyun-Soo Kim
Metaplastic papillary tumor (MPT) of the fallopian tube is a very uncommon lesion, displaying papillary growth of bland-appearing cells with abundant, eosinophilic cytoplasm and mucinous metaplasia. It is difficult for pathologists to determine whether to categorize this lesion as a metaplastic proliferative lesion or a true neoplasm. We recently experienced a case of tubal MPT and initiated a comprehensive review of previously published cases with thorough analysis of clinicopathological characteristics. MPT is typically related to pregnancy, but we describe the first case of pregnancy-unrelated, incidentally detected tubal MPT in a 51-year-old woman who underwent surgery for endometrial cancer...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28664577/the-medial-pterygoid-muscle-a-stabiliser-of-horizontal-jaw-movement
#18
H Chen, T Whittle, J A Gal, G M Murray, I J Klineberg
There is limited information of the normal function of the human medial pterygoid muscle (MPt). The aims were to determine whether (i) the MPt is active throughout horizontal jaw movements with the teeth apart and (ii) whether single motor units (SMUs) are active during horizontal and opening-closing jaw movements. Intramuscular electrodes were placed in the right MPt of 18 participants who performed five teeth-apart tasks: (i) postural position, (ii) ipsilateral (i.e. right) jaw movement, (iii) contralateral movement, (iv) protrusive movement and (v) opening-closing movement...
June 29, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28647376/mitochondrial-permeability-transition-pore-back-to-the-drawing-board
#19
Christos Chinopoulos
Current models theorizing on what the mitochondrial permeability transition (mPT) pore is made of, implicate the c-subunit rings of ATP synthase complex. However, two very recent studies, one on atomistic simulations and in the other disrupting all genes coding for the c subunit disproved those models. As a consequence of this, the structural elements of the pore remain unknown. The purpose of the present short-review is to (i) briefly review the latest findings, (ii) serve as an index for more comprehensive reviews regarding mPT specifics, (iii) reiterate on the potential pitfalls while investigating mPT in conjunction to bioenergetics, and most importantly (iv) suggest to those in search of mPT pore identity, to also look elsewhere...
June 21, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28634393/a-small-molecule-ds44170716-inhibits-ca-2-induced-mitochondrial-permeability-transition
#20
Naohiro Kon, Atsushi Satoh, Naoki Miyoshi
Mitochondria are involved in a variety of physiological and pathological processes. Ca(2+) uptake is one of the important functions of the organelle for maintenance of cellular Ca(2+) homeostasis. In pathological conditions such as ischemia reperfusion injury, Ca(2+) overload into mitochondria induces mitochondrial permeability transition (MPT), a critical step for cell death. Because inhibition of MPT is a promising approach to protecting cells and organs, it is important for drug discovery to identify novel chemicals or mechanisms to inhibit MPT...
June 20, 2017: Scientific Reports
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