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https://www.readbyqxmd.com/read/29667686/rheological-characterization-of-dynamic-remodeling-of-the-pericellular-region-by-human-mesenchymal-stem-cell-secreted-enzymes-in-well-defined-synthetic-hydrogel-scaffolds
#1
Maryam Daviran, Sarah M Longwill, Jonah F Casella, Kelly M Schultz
Human mesenchymal stem cells (hMSCs) dynamically remodel their microenvironment during basic processes, such as migration and differentiation. Migration requires extracellular matrix invasion, necessitating dynamic cell-material interactions. Understanding these interactions is critical to advancing materials designs that harness and manipulate these processes for applications including wound healing and tissue regeneration. In this work, we encapsulate hMSCs in a cell-degradable poly(ethylene glycol)-peptide hydrogel to determine how cell-secreted enzymes, specifically matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), create unique pericellular microenvironments...
April 18, 2018: Soft Matter
https://www.readbyqxmd.com/read/29653247/somatosensory-changes-at-forearm-donor-sites-following-three-different-surgical-flap-techniques
#2
Fang Wang, Xu Ding, Jinglu Zhang, Xiaomeng Song, Yunong Wu, Peter Svensson, Kelun Wang
BACKGROUND: The aim of this study was to investigate the somatosensory changes at the forearm donor region after using different types of modified flap surgical techniques. METHODS: Thirty-one patients, who underwent oral and maxillofacial reconstructive surgery involving the use of a traditional radial forearm flap (TRFF) or two modified radial forearm flap techniques (MRFF-I; MRFF-II), participated in the study. Cold detection threshold (CDT), warm detection threshold (WDT), cold pain threshold (CPT), heat pain threshold (HPT), pressure pain threshold (PPT), mechanical detection threshold (MDT), and mechanical pain threshold (MPT) were assessed at four sites of the forearms corresponding to the middle of the vascular pedicle (VP) area, the middle of the forearm flap area, and the corresponding contralateral sites (cVP and cFF) at about 5...
April 10, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29618684/-successful-treatment-with-thalidomide-combined-therapy-in-an-amyloidosis-complicated-multiple-myeloma-patient-refractory-to-bortezomib-lenalidomide-and-pomalidomide
#3
Yuka Aoki, Toshiaki Hayashi, Hiroshi Ikeda, Tadao Ishida
A 77-year-old man suffering from back and arm pain was referred for anemia to the hospital by an orthopedic clinic. Serum examination of the patient revealed monoclonal IgA, and he consulted the Sapporo Medical University Hospital, where he was diagnosed with multiple myeloma complicated with AL amyloidosis. He was then enrolled for a randomized double-blind study aimed to compare between melphalan-prednisone (MP) and thalidomide-melphalan-prednisone (MPT) treatments, which revealed the patient to be in the MP arm...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29615099/multimodal-label-free-imaging-of-living-dermal-equivalents-including-dermal-papilla-cells
#4
Aleksandra V Meleshina, Olga S Rogovaya, Varvara V Dudenkova, Marina A Sirotkina, Maria M Lukina, Alena S Bystrova, Victoria G Krut, Daria S Kuznetsova, Ekaterina P Kalabusheva, Andrey V Vasiliev, Ekaterina A Vorotelyak, Elena V Zagaynova
BACKGROUND: Despite the significant progress in the development of skin equivalents (SEs), the problem of noninvasively assessing the quality of the cell components and the collagen structure of living SEs both before and after transplantation remains. Undoubted preference is given to in vivo methods of noninvasive, label-free monitoring of the state of the SEs. Optical bioimaging methods, such as cross-polarization optical coherence tomography (CP OCT), multiphoton tomography (MPT), and fluorescence lifetime imaging microscopy (FLIM), present particular advantages for the visualization of such SEs...
April 3, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29614887/vocal-function-exercises-for-normal-voice-with-and-without-semi-occlusion
#5
Maria Bane, Megan Brown, Vrushali Angadi, Daniel J Croake, Richard D Andreatta, Joseph C Stemple
PURPOSE: This study examined the effect of varying degrees of vocal tract (VT) occlusion used during Vocal Function Exercises (VFEs) on attainment of maximum phonation time (MPT) goals in normal voice. Greater VT occlusion was expected to result in increased MPT. The overarching goal was to determine whether the semi-occluded vocal tract (SOVT) posture used during VFEs could be modified while preserving efficacy. METHOD: Twenty-six females ages 18-30 participated in this pre-post longitudinal group study...
April 3, 2018: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29604498/oxidative-stress-and-mitochondrial-dysfunction-mediated-cd-induced-hepatic-lipid-accumulation-in-zebrafish-danio-rerio
#6
Ya-Xiong Pan, Zhi Luo, Mei-Qing Zhuo, Chuan-Chuan Wei, Guang-Hui Chen, Yu-Feng Song
The present study was performed to determine the effect of waterborne CdCl2 exposure influencing lipid deposition and metabolism, oxidative stress and mitochondrial dysfunction, and explore the underlying molecular mechanism of cadmium (Cd)-induced disorder of hepatic lipid metabolism in fish. To this end, adult zebrafish were exposed to three waterborne CdCl2 concentrations (0(control), 5 and 25 μg Cd/l, respectively) for 30 days. Lipid accumulation, the activities of enzymes related to lipid metabolism and oxidative stress, as well as the expression level of genes involved in lipid metabolism and mitophagy were determined in the liver of zebrafish...
March 17, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29603199/indirubin-and-nad-prevent-mitochondrial-ischemia-reperfusion-damage-in-fatty-livers
#7
João Soeiro Teodoro, Ana Teresa Varela, Filipe Valente Duarte, Ana Patrícia Gomes, Carlos Marques Palmeira, Anabela Pinto Rolo
BACKGROUND: Fatty livers are considerably more susceptible to acute stressors, such as ischemia/reperfusion (I/R). Since the incidence of I/R is high due to surgical events and some pathologies, there is an urgent need to find strategies against I/R injury (I/RI) in fatty livers. We postulate that an acute pre-treatment with Indirubin-3'-oxime (Ind) or NAD+ prevents mitochondrial dysfunction associated with warm I/RI in fatty livers. MATERIALS AND METHODS: Zucker fatty rats were subjected to warm ischemia and 12 hrs of reperfusion...
March 30, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29600595/the-tablets-ring-injections-as-options-trio-study-what-young-african-women-chose-and-used-for-future-hiv-and-pregnancy-prevention
#8
Ariane van der Straten, Kawango Agot, Khatija Ahmed, Rachel Weinrib, Erica N Browne, Kgahlisho Manenzhe, Fredrick Owino, Jill Schwartz, Alexandra Minnis
INTRODUCTION: Preventing HIV and unintended pregnancies are key global health priorities. To inform product rollout and to understand attributes of future multipurpose prevention technologies (MPT) associated with preference and use, we evaluated three placebo delivery forms: daily oral tablets, a monthly vaginal ring, and two monthly intramuscular injections in TRIO, a five-month study among young Kenyan and South African women. METHODS: HIV-negative, sexually active, non-pregnant women aged 18 to 30 were enrolled and randomized to use each placebo delivery form for one month (stage 1)...
March 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29597046/omnidirectional-shear-horizontal-wave-based-tomography-for-damage-detection-in-a-metallic-plate-with-the-compensation-for-the-transfer-functions-of-transducer
#9
Dong Kyun Kim, Jun Kyu Lee, Hong Min Seung, Chung Il Park, Yoon Young Kim
Guided-wave based damage detection for plates has been widely studied for structural health monitoring. Because most of the earlier studies used dispersive Lamb waves, substantial efforts had to be made to alleviate the dispersive and multi-modal nature of Lamb waves and the effect of surface conditions. In contrast, shear-horizontal (SH) waves have better propagation characteristics suitable for the detection of damages in plates, but SH waves have not been widely used due to the lack of efficient methods to generate and sense omnidirectional SH waves...
March 17, 2018: Ultrasonics
https://www.readbyqxmd.com/read/29582254/2-4-dinitrophenol-attenuates-mitochondrial-dysfunction-and-improves-neurobehavioral-outcomes-postanoxia-in-neonatal-rats
#10
Puneet K Samaiya, Gopeshwar Narayan, Ashok Kumar, Sairam Krishnamurthy
Following anoxia, a rapid and marked mitochondrial-linked cell death occurs in the cerebral cortex of newborn rats which leads to insult advancement within a couple of days and causes lifelong neurobehavioral abnormalities. The present study investigated the role of 2,4 dinitrophenol (2,4 DNP) in three doses, i.e.,1, 2.5, and 5 mg/kg on anoxia-induced time-dependent mitochondrial dysfunction and associated neurobehavioral outcome using a well-established global model of anoxia. Briefly, rat pups of 30-h age (P2) were subjected to two episodes of anoxia (10 min each) at 24 h of the time interval in an enclosed chamber supplied with 100% N2 and immersed in a water bath (35-37 °C) to avoid hypothermia...
March 26, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29579559/attainment-of-gross-motor-milestones-by-preterm-children-with-normal-development-upon-school-entry
#11
Nienke H van Dokkum, Marlou L A de Kroon, Arend F Bos, Sijmen A Reijneveld, Jorien M Kerstjens
BACKGROUND: Little is known on the motor development of moderately preterm born (MPT) children, in comparison with early preterm born (EPT) children and fullterm born (FT), for children with normal motor outcomes at school entry. AIMS: To compare attainment rates of gross motor milestones reached between ages 1-24 months for MPT, EPT, and FT children, all with normal development upon school entry. STUDY DESIGN: Prospective cohort study. SUBJECTS: We included 1247 preterm (PT) children (gestational age [GA] 24...
March 23, 2018: Early Human Development
https://www.readbyqxmd.com/read/29568686/transthyretin-familial-amyloid-polyneuropathy-ttr-fap-parameters-for-early-diagnosis
#12
Fabiola Escolano-Lozano, Ana Paula Barreiros, Frank Birklein, Christian Geber
Background: Familial transthyretin amyloidosis is a life-threatening disease presenting with sensorimotor and autonomic polyneuropathy. Delayed diagnosis has a detrimental effect on treatment and prognosis. To facilitate diagnosis, we analyzed data patterns of patients with transthyretin familial amyloid polyneuropathy (TTR-FAP) and compared them to polyneuropathies of different etiology for clinical and electrophysiological discriminators. Methods: Twenty-four patients with TTR-FAP and 48 patients with diabetic polyneuropathy (dPNP) were investigated (neurological impairment score NIS; neurological disability score NDS) in a cross-sectional design...
January 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29560570/young-women-s-ratings-of-three-placebo-multipurpose-prevention-technologies-for-hiv-and-pregnancy-prevention-in-a-randomized-cross-over-study-in-kenya-and-south-africa
#13
Alexandra M Minnis, Sarah T Roberts, Kawango Agot, Rachel Weinrib, Khatija Ahmed, Kgahlisho Manenzhe, Fredrick Owino, Ariane van der Straten
End-user input is critical to inform development of multipurpose prevention technology (MPT) products that prevent HIV and pregnancy. The TRIO Study, conducted in Kenya and South Africa, enrolled 277 HIV-negative women aged 18-30 in a randomized cross-over study to use each placebo MPT (daily oral tablets, monthly injections, and monthly vaginal ring) for one month. At the end of each month, participants rated how much they liked using the product on a 5-point Likert scale (5 = liked very much). We compared mean ratings using paired t-tests and examined sociodemographic-, attribute-, and behavior-related characteristics associated with ratings using multivariable linear regression and data from in-depth interviews...
March 20, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29552717/occurrence-and-health-risk-assessment-of-organotins-in-waterworks-and-the-source-water-of-the-three-gorges-reservoir-region-china
#14
Ting Deng, Lei Wu, Jun-Min Gao, Bin Zhou, Ya-Li Zhang, Wen-Nan Wu, Zhuo-Heng Tang, Wen-Chao Jiang, Wei-Lin Huang
The occurrence and health risks of organotins (OTs) in the waterworks and source water in the Three Gorges Reservoir Region (TGRR), China were assessed in this study. Water samples were collected at four waterworks (A, B, C, and D) in March and July 2012 to analyze butyltins (BTs) and phenyltins (PTs) using a gas chromatography-mass spectrometry (GC-MS) system. Our results showed that both the waterworks and their nearby water sources were polluted by OTs, with PTs being the most dominant species. Monobutyltin (MBT), monophenyltin (MPT), diphenyltin (DPT), and triphenyltin (TPT) were detected in most of the analyzed water samples...
March 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29550215/estrogen-receptor-beta-modulates-permeability-transition-in-brain-mitochondria
#15
Suzanne R Burstein, Hyun Jeong Kim, Jasmine A Fels, Liping Qian, Sheng Zhang, Ping Zhou, Anatoly A Starkov, Costantino Iadecola, Giovanni Manfredi
Recent evidence highlights a role for sex and hormonal status in regulating cellular responses to ischemic brain injury and neurodegeneration. A key pathological event in ischemic brain injury is the opening of a mitochondrial permeability transition pore (MPT) induced by excitotoxic calcium levels, which can trigger irreversible damage to mitochondria accompanied by the release of pro-apoptotic factors. However, sex differences in brain MPT modulation have not yet been explored. Here, we show that mitochondria isolated from female mouse forebrain have a lower calcium threshold for MPT than male mitochondria, and that this sex difference depends on the MPT regulator cyclophilin D (CypD)...
March 14, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29548270/reduced-hip-adduction-is-associated-with-improved-function-after-movement-pattern-training-in-young-people-with-chronic-hip-joint-pain
#16
Marcie Harris-Hayes, Karen Steger-May, Linda R Van Dillen, Mario Schootman, Gretchen B Salsich, Sylvia Czuppon, John C Clohisy, Paul K Commean, Travis J Hillen, Shirley A Sahrmann, Michael J Mueller
Study Design Ancillary analysis, time-controlled randomized clinical trial. Background Movement pattern training (MPT) has been shown to improve function among patients with chronic hip joint pain (CHJP). Objective Determine the association among treatment outcomes and mechanical factors associated with CHJP. Methods Twenty-eight patients with CHJP, 18-40 years, participated in MPT, either immediately after assessment or after a wait-list period. MPT included task-specific training to reduce hip adduction motion during functional tasks and hip muscle strengthening...
March 16, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29535401/100-kyr-cyclicity-in-volcanic-ash-emplacement-evidence-from-a-1-1-myr-tephra-record-from-the-nw-pacific
#17
Julie C Schindlbeck, Marion Jegen, Armin Freundt, Steffen Kutterolf, Susanne M Straub, Maryline J Mleneck-Vautravers, Jerry F McManus
It is a longstanding observation that the frequency of volcanism periodically changes at times of global climate change. The existence of causal links between volcanism and Earth's climate remains highly controversial, partly because most related studies only cover one glacial cycle. Longer records are available from marine sediment profiles in which the distribution of tephras records frequency changes of explosive arc volcanism with high resolution and time precision. Here we show that tephras of IODP Hole U1437B (northwest Pacific) record a cyclicity of explosive volcanism within the last 1...
March 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29531827/-mycobacterium-fortuitum-induced-er-mitochondrial-calcium-dynamics-promotes-calpain-caspase-12-caspase-9-mediated-apoptosis-in-fish-macrophages
#18
Debika Datta, Preeti Khatri, Ambika Singh, Dhira Rani Saha, Gaurav Verma, Rajagopal Raman, Shibnath Mazumder
Mycobacterium fortuitum is a natural fish pathogen. It induces apoptosis in headkidney macrophages (HKM) of catfish, Clarias sp though the mechanism remains largely unknown. We observed M. fortuitum triggers calcium (Ca2+ ) insult in the sub-cellular compartments which elicits pro-apototic ER-stress factor CHOP. Alleviating ER-stress inhibited CHOP and attenuated HKM apoptosis implicating ER-stress in the pathogenesis of M. fortuitum . ER-stress promoted calpain activation and silencing the protease inhibited caspase-12 activation...
December 2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29526526/the-dual-role-of-mitochondrial-superoxide-in-arsenite-toxicity-signaling-at-the-boundary-between-apoptotic-commitment-and-cytoprotection
#19
Mara Fiorani, Andrea Guidarelli, Valentina Capellacci, Liana Cerioni, Rita Crinelli, Orazio Cantoni
Arsenite toxicity is in numerous cellular systems dependent on the formation of reactive oxygen and or nitrogen species. This is also true in U937 cells in which the metalloid selectively promotes the formation of mitochondrial superoxide (mitoO2 - ) rapidly converted to diffusible H2 O2 . We tested the hypothesis that, under the same conditions, mitoO2 - also mediates the triggering of a parallel survival signaling. We found that a low concentration of the metalloid causes an early activation of nuclear factor erythroid 2 p45-related factor 2 (Nrf2), and a downstream signaling leading to enhanced GSH biosynthesis, via a mechanism sensitive to various treatments/strategies selectively preventing mitoO2 - formation...
March 8, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29507286/sea-ice-dynamics-across-the-mid-pleistocene-transition-in-the-bering-sea
#20
H Detlef, S T Belt, S M Sosdian, L Smik, C H Lear, I R Hall, P Cabedo-Sanz, K Husum, S Kender
Sea ice and associated feedback mechanisms play an important role for both long- and short-term climate change. Our ability to predict future sea ice extent, however, hinges on a greater understanding of past sea ice dynamics. Here we investigate sea ice changes in the eastern Bering Sea prior to, across, and after the Mid-Pleistocene transition (MPT). The sea ice record, based on the Arctic sea ice biomarker IP25 and related open water proxies from the International Ocean Discovery Program Site U1343, shows a substantial increase in sea ice extent across the MPT...
March 5, 2018: Nature Communications
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