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https://www.readbyqxmd.com/read/29208362/feminizing-effects-of-exposure-to-corexit-enhanced-water-accommodated-fraction-of-crude-oil-in-vitro-on-sex-determination-in-alligator-mississippiensis
#1
Cameron E Williams, Nicole A McNabb, Arnold Brunell, Russell H Lowers, Yoshinao Katsu, Demetri D Spyropoulos, Satomi Kohno
Deepwater Horizon spilled over 200 million gallons of oil into the waters of the Gulf of Mexico in 2010. In an effort to contain the spill, chemical dispersants were applied to minimize the amount of oil reaching coastal shorelines. However, the biological impacts of chemically-dispersed oil are not well characterized, and there is a particular lack of knowledge concerning sublethal long-term effects of exposure. This study examined potential estrogenic effects of CWAF, Corexit 9500-enhanced water-accommodated fraction of oil, by examining its effect on estrogen receptors and sex determination in the American alligator, Alligator mississippiensis...
December 2, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29180424/causes-of-ice-age-intensification-across-the-mid-pleistocene-transition
#2
Thomas B Chalk, Mathis P Hain, Gavin L Foster, Eelco J Rohling, Philip F Sexton, Marcus P S Badger, Soraya G Cherry, Adam P Hasenfratz, Gerald H Haug, Samuel L Jaccard, Alfredo Martínez-García, Heiko Pälike, Richard D Pancost, Paul A Wilson
During the Mid-Pleistocene Transition (MPT; 1,200-800 kya), Earth's orbitally paced ice age cycles intensified, lengthened from ∼40,000 (∼40 ky) to ∼100 ky, and became distinctly asymmetrical. Testing hypotheses that implicate changing atmospheric CO2 levels as a driver of the MPT has proven difficult with available observations. Here, we use orbitally resolved, boron isotope CO2 data to show that the glacial to interglacial CO2 difference increased from ∼43 to ∼75 μatm across the MPT, mainly because of lower glacial CO2 levels...
November 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29175222/temporal-lobe-asymmetry-in-fdg-pet-uptake-predicts-neuropsychological-and-seizure-outcomes-after-temporal-lobectomy
#3
Janina Kamm, Laura L Boles Ponto, Ken Manzel, Owen J Gaasedelen, Yasunori Nagahama, Taylor Abel, Daniel Tranel
OBJECTIVE: The objective of this study was to determine whether preoperative [18F]fludeoxyglucose (FDG)-positron emission tomography (PET) asymmetry in temporal lobe metabolism predicts neuropsychological and seizure outcomes after temporal lobectomy (TL). METHODS: An archival sample of 47 adults with unilateral temporal lobe epilepsy who underwent TL of their language-dominant (29 left, 1 right) or nondominant (17 right) hemisphere were administered neuropsychological measures pre- and postoperatively...
November 22, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29160142/structural-fat-grafting-to-improve-outcomes-of-vocal-folds-fat-augmentation-long-term-results
#4
Giovanna Cantarella, Riccardo F Mazzola, Michele Gaffuri, Elisabetta Iofrida, Pietro Biondetti, Laura V Forzenigo, Lorenzo Pignataro, Sara Torretta
Objective Evaluating the long-term outcomes of vocal fold structural fat grafting. Study Design Case series with chart review. Setting University hospital. Subjects and Methods Seventy-nine dysphonic patients (16-82 years; 55 with unilateral laryngeal paralysis and 24 with vocal fold scarring) underwent vocal fold fat injection. Fat was harvested by low-pressure liposuction and then processed by centrifugation. Refined fat aliquots were placed in the vocal fold and paraglottic space in multiple tunnels to enhance graft neovascularization...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29158931/atypical-distant-metastasis-of-breast-malignant-phyllodes-tumors-a-case-report-and-literature-review
#5
Tiphaine de Foucher, Hélène Roussel, Mikael Hivelin, Léa Rossi, Caroline Cornou, Anne-Sophie Bats, Myriam Deloménie, Fabrice Lécuru, Charlotte Ngô
Malignant phyllodes tumors (MPT) are rare breast neoplasms. Preoperative diagnosis is often challenging due to the unspecific clinical, radiological, and histological characteristics of the tumor. Dissemination pathways are local with chest wall invasion, regional with lymph nodes metastasis, and distant, hematogenous, mostly to the lungs, bones, and brain. Distant metastasis (DM) can be synchronous or appear months to years after the diagnosis and initial management. The current report describes the case of a 57-year-old woman presenting with a giant/neglected MPT of the breast, with no DM at initial staging, treated by radical modified mastectomy...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29150421/final-analysis-of-survival-outcomes-in-the-randomized-phase-3-first-trial
#6
Thierry Facon, Meletios A Dimopoulos, Angela Dispenzieri, John V Catalano, Andrew Belch, Michele Cavo, Antonello Pinto, Katja Weisel, Heinz Ludwig, Nizar J Bahlis, Anne Banos, Mourad Tiab, Michel Delforge, Jamie D Cavenagh, Catarina Geraldes, Je-Jung Lee, Christine Chen, Albert Oriol, Javier De La Rubia, Darell White, Daniel Binder, Jin Lu, Kenneth C Anderson, Philippe Moreau, Michel Attal, Aurore Perrot, Bertrand Arnulf, Lugui Qiu, Murielle Roussel, Eileen Boyle, Salomon Manier, Mohamad Mohty, Herve Avet-Loiseau, Xavier Leleu, Annette Ervin-Haynes, Guang Chen, Vanessa Houck, Lotfi Benboubker, Cyrille Hulin
This FIRST trial final analysis examined survival outcomes in patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM) treated with lenalidomide and low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks). The primary endpoint was progression-free survival (PFS; primary comparison: Rd continuous vs MPT). Overall survival (OS) was a key secondary endpoint (final analysis prespecified ≥ 60 months' follow-up)...
November 17, 2017: Blood
https://www.readbyqxmd.com/read/29145046/genetic-and-clinical-characteristics-of-phyllodes-tumors-of-the-breast
#7
Ji-Yeon Kim, Jong Han Yu, Seok Jin Nam, Seok Won Kim, Se Kyung Lee, Woong-Yang Park, Dong-Young Noh, Do-Hyun Nam, Yeon Hee Park, Wonshik Han, Jeong Eon Lee
PURPOSE: Phyllodes tumors (PTs) of the breast are rare, accounting for less than 1% of all breast tumors. Among PTs, malignant PTs (MPTs) have malignant characteristics and distant metastases occur in about 20% to 30% of MPTs. However, there is no effective treatment for MPTs with distant metastasis, resulting in an abject prognosis. We performed targeted deep sequencing on PTs to identify the associations between genetic alterations and clinical prognosis. METHODS: We performed targeted deep sequencing to evaluate the genetic characteristics of PTs and analyzed the relationships between clinical and genetic characteristics...
November 12, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29120753/mitochondrial-oxphos-induced-by-rb1-deficiency-in-breast-cancer-implications-for-anabolic-metabolism-stemness-and-metastasis
#8
REVIEW
Eldad Zacksenhaus, Mariusz Shrestha, Jeff C Liu, Ioulia Vorobieva, Philip E D Chung, YoungJun Ju, Uri Nir, Zhe Jiang
A switch from catabolic to anabolic metabolism, a major hallmark of cancer, enables rapid cell duplication, and is driven by multiple oncogenic alterations, including PIK3CA mutation, MYC amplification, and TP53 loss. However, tumor growth requires active mitochondrial function and oxidative phosphorylation (OXPHOS). Recently, loss of the retinoblastoma (RB1) tumor suppressor in breast cancer was shown to induce mitochondrial protein translation (MPT) and OXPHOS. Here, we discuss how increased OXPHOS can enhance anabolic metabolism and cell proliferation, as well as cancer stemness and metastasis...
November 2017: Trends in Cancer
https://www.readbyqxmd.com/read/29119664/effects-of-body-condition-score-bcs-on-steroid-and-eicosanoid-metabolizing-enzyme-activity-in-various-mare-tissues-during-winter-anoestrus
#9
Mpt Owen, E N Ferjak, C A Cavinder, K J McCarty, K C Yankey, C G Hart, D D Burnett, Ttn Dinh, C O Lemley
The objective of this study was to determine the activity of steroid- and eicosanoid-metabolizing enzymes in horses with varying BCSs. The BCSs of twenty non-pregnant, anoestrous mares were determined prior to euthanasia, and tissue samples were collected from the liver, kidney, adrenal gland, ovary and endometrium. Cytochrome P450 1A (CYP1A), 2C (CYP2C), 3A (CYP3A) and uridine 5'-diphospho-glucuronosyltransferase (UGT) activities were determined using luminogenic substrates. The MIXED procedure of SAS was used to test the effect of BCS on enzyme activity and differences between tissues...
November 8, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29113755/early-developmental-trajectories-of-preterm-infants
#10
Maya Yaari, David Mankuta, Ayelet Harel-Gadassi, Edwa Friedlander, Benjamin Bar-Oz, Smadar Eventov-Friedman, Nimrod Maniv, David Zucker, Nurit Yirmiya
BACKGROUND AND OBJECTIVES: Preterm infants are at risk for neuro-developmental impairments and atypical developmental trajectories. The aims of this study were to delineate early developmental trajectories of preterm and full-term infants. METHODS: The cognitive, language, and motor development of 149 infants - 19 extremely preterm (EPT), 34 very preterm (VPT), 57 moderately preterm (MPT), and 39 full-term (FT) - was evaluated using Mullen Scales at 1, 4, 8, 12, and 18 months...
November 4, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29084372/a-phase-i-ii-exploratory-clinical-trial-for-intracordal-injection-of-recombinant-hepatocyte-growth-factor-for-vocal-fold-scar-and-sulcus
#11
Shigeru Hirano, Atsuhiko Kawamoto, Ichiro Tateya, Masanobu Mizuta, Yo Kishimoto, Nao Hiwatashi, Yoshitaka Kawai, Takuya Tsuji, Ryo Suzuki, Mami Kaneko, Yasushi Naito, Tatsuo Kagimura, Tatsuo Nakamura, Shin-Ichi Kanemaru
BACKGROUND: Vocal fold scar and sulcus are intractable diseases with no effective established treatments. Hepatocyte growth factor (HGF) has preclinically proven to have potent anti-fibrotic and regenerative effects on vocal fold scar. The current phase I/II clinical trial aims to examine the safety and effectiveness of intracordal injection of a recombinant human HGF drug for patients with vocal fold scar or sulcus. STUDY DESIGN: Phase I/II, open-label, dose-escalating, first-in-human clinical trial...
October 30, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29055782/interest-in-multipurpose-prevention-technologies-to-prevent-hiv-stis-and-unintended-pregnancy-among-young-women-in-the-united-states
#12
Jenna S Hynes, Jessica M Sales, Anandi N Sheth, Eva Lathrop, Lisa B Haddad
OBJECTIVE: High rates of sexually transmitted infections (STIs) and unintended pregnancy suggest a role for multipurpose prevention technologies (MPTs) designed to combine contraception and infection prophylaxis into one unified method. This study aims to determine factors associated with interest in MPTs among U.S. women. STUDY DESIGN: We administered a national cross-sectional survey via MTurk. Eligibility criteria included female gender, age 18-29years, residence in the U...
October 18, 2017: Contraception
https://www.readbyqxmd.com/read/29052018/end-users-product-preference-across-three-multipurpose-prevention-technology-delivery-forms-baseline-results-from-young-women-in-kenya-and-south-africa
#13
Rachel Weinrib, Alexandra Minnis, Kawango Agot, Khatija Ahmed, Fred Owino, Kgahlisho Manenzhe, Helen Cheng, Ariane van der Straten
A multipurpose prevention technology (MPT) that combines HIV and pregnancy prevention is a promising women's health intervention, particularly for young women. However, little is known about the drivers of acceptability and product choice for MPTs in this population. This paper explores approval ratings and stated choice across three different MPT delivery forms among potential end-users. The Trio Study was a mixed-methods study in women ages 18-30 that examined acceptability of three MPT delivery forms: oral tablets, injections, and vaginal ring...
October 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29040993/hemodynamic-changes-on-cone-beam-computed-tomography-during-balloon-occluded-transcatheter-arterial-chemoembolization-using-miriplatin-for-hepatocellular-carcinoma-a-preliminary-study
#14
Toru Ishikawa, Michitaka Imai, Takashi Owaki, Hiroki Sato, Yujiro Nozawa, Tomoe Sano, Akito Iwanaga, Keiichi Seki, Terasu Honma, Toshiaki Yoshida, Masatoshi Kudo
BACKGROUND/AIM: Balloon-occluded transcatheter arterial chemoembolization (B-TACE) using miriplatin (MPT) is anticipated as a new strategy for hepatocellular carcinoma (HCC). This study was aimed at evaluating the hemodynamic changes with/without balloon occlusion of the hepatic artery, correlation of cone-beam CT (CBCT) pixels, and CT value after B-TACE for HCC. METHODS: A total of 52 patients with HCC, who underwent B-TACE using MPT in addition to the balloon-occluded CBCT hepatic arteriography, were studied...
2017: Digestive Diseases
https://www.readbyqxmd.com/read/29024230/%C3%AE-aminobutyric-acid-gaba-oral-rinse-reduces-capsaicin-induced-burning-mouth-pain-sensation-an-experimental-quantitative-sensory-testing-study-in-healthy-subjects
#15
Y Zhang, K Wang, L Arendt-Nielsen, B E Cairns
BACKGROUND: In burning mouth patients, analgesia after oral administration of clonazepam may result from modulation of peripheral γ-aminobutyric acid (GABA) receptors. METHODS: The effect of oral administration of test solutions (water, 0.5 mol/L or 0.05 mol/L GABA, 1% lidocaine) was investigated for the amelioration of pain and sensitivity induced by application of capsaicin (1%, 2 min) to the tongue of thirty healthy male and female subjects in this four-session, randomized, placebo-controlled, double-blinded, cross-over study...
October 11, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29022987/double-mesoporous-core-shell-nanosystems-based-on-platinum-nanoparticles-functionalized-with-lanthanide-complexes-for-in-vivo-magnetic-resonance-imaging-and-photothermal-therapy
#16
Lei Zhao, Xiaoqian Ge, Guihua Yan, Xiao Wang, Pengfei Hu, Liyi Shi, Otto S Wolfbeis, Hongjie Zhang, Lining Sun
A double-mesoporous nanosystem was synthesized for treating as well as imaging cancer cells by using a simple and mild method. The mesoporous platinum (Pt) nanoparticles acting as a core show excellent photothermal effect under illumination with an 808 nm near infrared (NIR) laser. The mesoporous silica linked with a lanthanide (Gd) complex acting as a shell displays potential applications as a contrast agent for magnetic resonance imaging (MRI). The final mPt@mSiO2-GdDTPA nanosystems exhibit good biocompatibility in vitro and in vivo, when investigated by methyl thiazolyl tetrazolium assay and histological and serum biochemistry analysis...
October 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/29017661/-advances-in-the-role-of-autophagy-in-acute-pancreatitis
#17
He Xia, Liang Zhao, Weixing Wang
Autophagy is a self-protect cellular mechanism by which the unneeded cellular structure or impaired protein are targeted to degeneration. Acute pancreatitis (AP) is associated with autophagy tightly. This article is aimed to mainly elaborate the phenomenon that AP can be triggered by impaired autophagy and the mechanism of AP exacerbation by damaged autophagy. In AP, the reasons of impaired autophagy is dysfunction of cathepsins and lysosome associated membrane protein, which present as vacuoles accumulation in acinar cells and combination disorder of autophagolysosome, finally to activation of trypsin...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28990440/influence-of-passive-joint-stiffness-on-proprioceptive-acuity-in-individuals-with-functional-ankle-instability
#18
Hellen Veloso Rocha Marinho, Giovanna Mendes Amaral, Bruno de Souza Moreira, Vanessa Lara Araújo, Thales Rezende Souza, Juliana Melo Ocarino, Sérgio Teixeira da Fonseca
Study Design Controlled Laboratory Study; Cross-sectional. Background Deficits in ankle proprioceptive acuity have been reported in persons with functional instability of the ankle. Passive stiffness has been proposed as a possible mechanism underlying proprioceptive acuity. Objectives 1) to compare proprioceptive acuity and passive ankle stiffness between persons with and without functional ankle instability, and 2) to assess the influence of passive joint stiffness on the proprioceptive acuity in persons with functional ankle instability...
October 7, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28985238/the-pain-threshold-of-high-threshold-mechanosensitive-receptors-subsequent-to-maximal-eccentric-exercise-is-a-potential-marker-in-the-prediction-of-doms-associated-impairment
#19
Johannes Fleckenstein, Perikles Simon, Matthias König, Lutz Vogt, Winfried Banzer
BACKGROUND: Delayed-onset muscle soreness (DOMS) refers to dull pain and discomfort in people after participating in exercise, sport or recreational physical activities. The aim of this study was to detect underlying mechanical thresholds in an experimental model of DOMS. METHODS: Randomised study to detect mechanical pain thresholds in a randomised order following experimentally induced DOMS of the non-dominant arm in healthy participants. Main outcome was the detection of the pressure pain threshold (PPT), secondary thresholds included mechanical detection (MDT) and pain thresholds (MPT), pain intensity, pain perceptions and the maximum isometric voluntary force (MIVF)...
2017: PloS One
https://www.readbyqxmd.com/read/28982161/novel-multipurpose-pod-intravaginal-ring-for-the-prevention-of-hiv-hsv-and-unintended-pregnancy-pharmacokinetic-evaluation-in-a-macaque-model
#20
James M Smith, John A Moss, Priya Srinivasan, Irina Butkyavichene, Manjula Gunawardana, Rob Fanter, Christine S Miller, Debbie Sanchez, Flora Yang, Shanon Ellis, Jining Zhang, Mark A Marzinke, Craig W Hendrix, Amita Kapoor, Marc M Baum
Globally, women bear an uneven burden for sexual HIV acquisition. Results from two clinical trials evaluating intravaginal rings (IVRs) delivering the antiretroviral agent dapivirine have shown that protection from HIV infection can be achieved with this modality, but high adherence is essential. Multipurpose prevention technologies (MPTs) can potentially increase product adherence by offering protection against multiple vaginally transmitted infections and unintended pregnancy. Here we describe a coitally independent, long-acting pod-IVR MPT that could potentially prevent HIV and HSV infection as well as unintended pregnancy...
2017: PloS One
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