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Toru Ishikawa, Michitaka Imai, Takashi Owaki, Hiroki Sato, Yujiro Nozawa, Tomoe Sano, Akito Iwanaga, Keiichi Seki, Terasu Honma, Toshiaki Yoshida, Masatoshi Kudo
BACKGROUND/AIM: Balloon-occluded transcatheter arterial chemoembolization (B-TACE) using miriplatin (MPT) is anticipated as a new strategy for hepatocellular carcinoma (HCC). This study was aimed at evaluating the hemodynamic changes with/without balloon occlusion of the hepatic artery, correlation of cone-beam CT (CBCT) pixels, and CT value after B-TACE for HCC. METHODS: A total of 52 patients with HCC, who underwent B-TACE using MPT in addition to the balloon-occluded CBCT hepatic arteriography, were studied...
2017: Digestive Diseases
Y Zhang, K Wang, L Arendt-Nielsen, B E Cairns
BACKGROUND: In burning mouth patients, analgesia after oral administration of clonazepam may result from modulation of peripheral γ-aminobutyric acid (GABA) receptors. METHODS: The effect of oral administration of test solutions (water, 0.5 mol/L or 0.05 mol/L GABA, 1% lidocaine) was investigated for the amelioration of pain and sensitivity induced by application of capsaicin (1%, 2 min) to the tongue of thirty healthy male and female subjects in this four-session, randomized, placebo-controlled, double-blinded, cross-over study...
October 11, 2017: European Journal of Pain: EJP
Lei Zhao, Xiaoqian Ge, Guihua Yan, Xiao Wang, Pengfei Hu, Liyi Shi, Otto S Wolfbeis, Hongjie Zhang, Lining Sun
A double-mesoporous nanosystem was synthesized for treating as well as imaging cancer cells by using a simple and mild method. The mesoporous platinum (Pt) nanoparticles acting as a core show excellent photothermal effect under illumination with an 808 nm near infrared (NIR) laser. The mesoporous silica linked with a lanthanide (Gd) complex acting as a shell displays potential applications as a contrast agent for magnetic resonance imaging (MRI). The final mPt@mSiO2-GdDTPA nanosystems exhibit good biocompatibility in vitro and in vivo, when investigated by methyl thiazolyl tetrazolium assay and histological and serum biochemistry analysis...
October 12, 2017: Nanoscale
He Xia, Liang Zhao, Weixing Wang
Autophagy is a self-protect cellular mechanism by which the unneeded cellular structure or impaired protein are targeted to degeneration. Acute pancreatitis (AP) is associated with autophagy tightly. This article is aimed to mainly elaborate the phenomenon that AP can be triggered by impaired autophagy and the mechanism of AP exacerbation by damaged autophagy. In AP, the reasons of impaired autophagy is dysfunction of cathepsins and lysosome associated membrane protein, which present as vacuoles accumulation in acinar cells and combination disorder of autophagolysosome, finally to activation of trypsin...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Hellen Veloso Rocha Marinho, Giovanna Mendes Amaral, Bruno de Souza Moreira, Vanessa Lara Araújo, Thales Rezende Souza, Juliana Melo Ocarino, Sérgio Teixeira da Fonseca
Study Design Controlled Laboratory Study; Cross-sectional. Background Deficits in ankle proprioceptive acuity have been reported in persons with functional instability of the ankle. Passive stiffness has been proposed as a possible mechanism underlying proprioceptive acuity. Objectives 1) to compare proprioceptive acuity and passive ankle stiffness between persons with and without functional ankle instability, and 2) to assess the influence of passive joint stiffness on the proprioceptive acuity in persons with functional ankle instability...
October 7, 2017: Journal of Orthopaedic and Sports Physical Therapy
Johannes Fleckenstein, Perikles Simon, Matthias König, Lutz Vogt, Winfried Banzer
BACKGROUND: Delayed-onset muscle soreness (DOMS) refers to dull pain and discomfort in people after participating in exercise, sport or recreational physical activities. The aim of this study was to detect underlying mechanical thresholds in an experimental model of DOMS. METHODS: Randomised study to detect mechanical pain thresholds in a randomised order following experimentally induced DOMS of the non-dominant arm in healthy participants. Main outcome was the detection of the pressure pain threshold (PPT), secondary thresholds included mechanical detection (MDT) and pain thresholds (MPT), pain intensity, pain perceptions and the maximum isometric voluntary force (MIVF)...
2017: PloS One
James M Smith, John A Moss, Priya Srinivasan, Irina Butkyavichene, Manjula Gunawardana, Rob Fanter, Christine S Miller, Debbie Sanchez, Flora Yang, Shanon Ellis, Jining Zhang, Mark A Marzinke, Craig W Hendrix, Amita Kapoor, Marc M Baum
Globally, women bear an uneven burden for sexual HIV acquisition. Results from two clinical trials evaluating intravaginal rings (IVRs) delivering the antiretroviral agent dapivirine have shown that protection from HIV infection can be achieved with this modality, but high adherence is essential. Multipurpose prevention technologies (MPTs) can potentially increase product adherence by offering protection against multiple vaginally transmitted infections and unintended pregnancy. Here we describe a coitally independent, long-acting pod-IVR MPT that could potentially prevent HIV and HSV infection as well as unintended pregnancy...
2017: PloS One
Hideo Yagi
In Japan, the latest trends in induction therapy for patients newly diagnosed with multiple myeloma are multi-drug combinations, including bortezomib, lenalidomide, and thalidomide. Patients <65 years old and those <70 years old who have normal cardiac and lung functions without any serious complications are good candidates for high-dose L-PAM with autologous stem cell transplantation. For successful stem cell collection, anti-cancer drugs that have a negative impact on stem cell mobilization are usually excluded from induction therapies...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Nicole Eichhorn, Rolf-Detlef Treede, Sigrid Schuh-Hofer
Sex matters both in the clinical field of pain and sleep medicine. Sleep disturbances are highly prevalent in chronic pain patients and have been shown to deteriorate the pain condition. The pathomechanisms by which insomnia aggravates pain are currently unknown. Descending pain control may be compromised by disturbed sleep, but respective studies are few, inconsistent and largely imbalanced with respect to sex. We studied the role of sex on the effect of sleep deprivation on endogenous pain modulation and on nociceptive thresholds in a highly homogenous study population of 18 female (23...
October 1, 2017: Neuroscience
Joe E Springer, Nishant Visavadiya, Patrick G Sullivan, Edward D Hall
Mitochondrial homeostasis is essential for maintaining cellular function and survival in the central nervous system (CNS). Mitochondrial function is significantly compromised following spinal cord injury (SCI) and is associated with accumulation of high levels of calcium, increased production of free radicals, oxidative damage, and eventually mitochondrial permeability transition (mPT). The formation of the mPT pore (mPTP) and subsequent mPT state are considered to be end stage events in the decline of mitochondrial integrity, and strategies that inhibit mPT can limit mitochondrial demise...
October 1, 2017: Journal of Neurotrauma
Lies Depestele, Laurence Claes, Eva Dierckx, Roos Colman, Katrien Schoevaerts, Gilbert M D Lemmens
This study reports on a pilot study of a family group intervention with or without patient participation adjunctive to a specialized inpatient treatment for eating disorders (EDs). Participants were 112 female adolescent ED inpatients and one or both of their parents. The parents were invited to participate in an adjunctive multi-family group with patient (MFT) or in a similar multi-parent group without patient participation (MPT). Questionnaires assessing ED symptoms, family functioning and caregiving experiences were administered before and after intervention...
September 29, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
Yanting Wang, Xueyin Mo, Jinglu Zhang, Yuan Fan, Kelun Wang, Svensson Peter
OBJECTIVE: To establish a preliminary thermal and mechanical somatosensory profile using a standardized quantitative sensory testing (QST) to investigate site, gender and age differences in healthy Chinese. MATERIALS AND METHODS: Twenty younger (age: 20-40 years, 10 men, 10 women) and twenty older (age: 41-61 years, 10 men, 10 women) healthy participants completed the study. Cold detection threshold (CDT), warm detection threshold (WDT), cold pain threshold (CPT), heat pain threshold (HPT), mechanical detection threshold (MDT) and mechanical pain threshold (MPT) were measured at five sites: Left hand, bilaterally at the mental area, tip of tongue and the lower lip mucosa...
September 28, 2017: Acta Odontologica Scandinavica
Waqar K Saeed, Dae Won Jun, Kiseok Jang, Yeon Ji Chae, Jai Sun Lee, Hyeon Tae Kang
BACKGROUND: Previous studies have demonstrated protective effects of anti-receptor interacting protein kinase 1 (RIP1), a key necroptosis molecule. However, it is uncertain whether necroptosis has a crucial role in hepatic IR injury. Therefore, we evaluated the role of necroptosis in hepatic IR injury. METHOD: The IR mice underwent 70% segmental IR injury induced by the clamping of the hepatic artery and portal vein for 1 hr followed by reperfusion for 4 hr. The key necroptosis molecules (RIP1, RIP3, and MLKL) and other key molecules of regulated necrosis (PGAM5 and caspase-1) were evaluated in the warm IR injury model...
2017: PloS One
Abdul Mannan, Shagufta Iram, Adeel Ahmad, Shahida Hussain, Bilal Munir Ahmad
Tuberculosis (TB) is an airborne infectious disease caused by Mycobacterium tuberculosis. The genus Mycobacterium comprises over 150 species. Non-tuberculosis Mycobacteria are the cause of opportunistic infections and frequently presents with similar clinical features like tuberculosis so species identification is important for management. The current study was designed for presumptive diagnosis of MTB by detecting MPT 64 and Cord formation and the sensitivity and specificity of Cord Formation in MGIT positive samples...
October 2017: JPMA. the Journal of the Pakistan Medical Association
Junqing Yang, Mei Zheng, Qiuju Liu, Meiling Zhu Chushan Yang, Yan Zhang, Zhiqiang Zhu
Microwave plasma torches (MPTs) can be used as simple and low power-consumption ambient ion sources. When MPT-mass spectrometry (MPT-MS) is applied in the detection of some metal elements, the metallic ions exhibit some novel features which are significantly different with those obtained by the traditional inductively coupled plasma (ICP)-mass spectrometry (ICP-MS) and may be helpful for metal element analysis. As the representative elements of group IVA, titanium and zirconium are both of importance and value in modern industry, and they have impacts on human health...
September 26, 2017: International Journal of Environmental Research and Public Health
Min Su Kim, Soon Ho Kweon, Seongyeon Cho, Seong Soo A An, Moon Il Kim, Junsang Doh, Jinwoo Lee
Development of facile and sensitive bioassays is important for many point-of-care applications. In this study, we fulfilled such demand by synthesizing Pt-decorated magnetic nanozymes and developing a bioassay based on unique properties of the newly synthesized nanozymes. Fe3O4-Pt/core-shell nanoparticles (MPt/CS NPs) with various compositions were synthesized and characterized. Fe3O4 NP itself is a good nanozyme with catalytic activity superior to that of natural enzymes, but catalytic activity can be further improved by incorporating Pt to the outer layers of the Fe3O4 NPs and building heterogeneous nanostructures...
October 11, 2017: ACS Applied Materials & Interfaces
Mamita Nayak, Susama Patra, Pritinanda Mishra, Nibedita Sahoo, Prakash Kumar Sasmal, Tushar Subhadarshan Mishra
Phyllodes tumors are uncommon fibroepithelial neoplasms of breast. Heterologous sarcomatous differentiation of malignant phyllodes tumor (MPT) is a rare phenomenon as shown in the literature. Herein we report a series of nine cases from a tertiary care centre in Eastern India. Patients demographic data and clinical details were obtained from the medical records. Histopathology and immunohistochemical studies were analysed and diagnosed accordingly. Out of 38 cases of PT, 13 were found to be MPT, of which 9 cases showed heterologous differentiation in the form of angiosarcoma, fibrosarcoma, undifferentiated sarcoma, extensive squamous differentiation and with lipomatous metaplasia...
July 2017: Indian Journal of Pathology & Microbiology
Shi-Xia Yang, Michael D Petraglia, Ya-Mei Hou, Jian-Ping Yue, Cheng-Long Deng, Ri-Xiang Zhu
Donggutuo (DGT) is one of the richest archaeological localities in the Nihewan Basin of North China, thereby providing key information about the technological behaviours of early hominins in eastern Asia. Although DGT has been subject of multiple excavations and technological studies over the past several decades, few detailed studies on the lithic assemblages have been published. Here we summarize and describe the DGT lithic assemblages, examining stone tool reduction methods and technological skills. DGT dates to ca...
2017: PloS One
Silvia Ambite-Quesada, José L Arías-Buría, Carol A Courtney, Lars Arendt-Nielsen, César Fernández-de-Las-Peñas
OBJECTIVE: To investigate somato-sensory nerve fibre function by applying different quantitative sensory testing including thermal, mechanical and vibration thresholds over latent trigger points (TrP) and in its associated referred pain area. METHODS: A total of 20 subjects with unilateral latent TrPs in the extensor carpi radialis brevis were included. Warmth detection threshold (WDT), cold detection threshold CDT) and heat/cold pain thresholds (HPT, CPT), mechanical detection (MDT) and pain (MPT) thresholds, vibration threshold (VT), and pressure pain thresholds (PPT) were blinded assessed over the TrP, in the referred pain area, and in the respective contra-lateral mirror areas...
September 29, 2017: Clinical Journal of Pain
Maria Bane, Vrushali Angadi, Emily Dressler, Richard Andreatta, Joseph Stemple
PURPOSE: This study examined the effect of varying dosage of vocal function exercise (VFE) home practice on attainment of pre-established maximum phonation time (MPT) goals in individuals with normal voice. High dosage VFE practice was expected to result in greatest MPT. The overarching goal of this study was to contribute to a VFE dosage-response curve, potentially including a point of observable toxicity. METHOD: Twenty-eight females ages 18-25 with normal voice participated in this pre-post longitudinal group study...
September 19, 2017: International Journal of Speech-language Pathology
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