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https://www.readbyqxmd.com/read/28548150/using-%C3%AE-2-rheology-to-quantify-rheological-properties-during-repeated-reversible-phase-transitions-of-soft-matter
#1
Matthew D Wehrman, Melissa J Milstrey, Seth Lindberg, Kelly M Schultz
A microfluidic device is designed to measure repeated phase transitions, gelation and degradation, on a single sample by exchanging the surrounding fluid while minimizing shear stress. This device enables quantitative microrheological characterization of material properties over multiple phase transitions, determining whether the material returns to the same equilibrium state. Fluid exchange is accomplished by using a two layer design, the sample is trapped in the first layer and the second layer is a well for the exchanging fluid...
May 26, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28545946/body-mass-index-and-acoustic-voice-parameters-is-there-a-relationship
#2
Lourdes Bernadete Rocha de Souza, Marquiony Marques Dos Santos
INTRODUCTION: Specific elements such as weight and body volume can interfere in voice production and consequently in its acoustic parameters, which is why it is important for the clinician to be aware of these relationships. OBJECTIVE: To investigate the relationship between body mass index (BMI) and the average acoustic voice parameters. METHODS: Observational, cross-sectional descriptive study. The sample consisted of 84 women, aged between 18 and 40years, an average of 26...
May 6, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28539339/mif-2-d-dt-enhances-proximal-tubular-cell-regeneration-through-slpi-and-atf4-dependent-mechanisms
#3
Akinobu Ochi, Dong Chen, Wibke Schulte, Lin Leng, Nickolas Gilbert Moeckel, Marta Piecychna, Luisa Averdunk, Christian Stoppe, Richard Bucala, Gilbert W Moeckel
Macrophage migration inhibitory factor (MIF) is a cytokine with pleiotropic actions that is produced by several organs and cell types. Depending on the target cell and the inflammatory context, MIF can engage its two component receptor complex CD74 and CD44, and the chemokine receptors CXCR2/4. MIF is constitutively expressed in renal proximal tubular cells, stored in intracellular preformed pools and is released at a low rate. Recently a second MIF-like protein (i.e. MIF-2/D-DT) has been characterized in mammals...
May 24, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28536722/apixaban-pharmacodynamic-activity-in-umbilical-cord-paediatric-and-adult-plasma
#4
Robert J Yetman, Yu Chen Barrett, Zhaoqing Wang, Robert Adamczyk, Jessie Wang, Eduardo Ramacciotti, Charles Frost
The objective was to characterise apixaban pharmacodynamic (PD) activity in umbilical cord (UC), paediatric, and adult plasma. Plasma was obtained from blood samples from six UC donors, 70 paediatric (neonates [birth-≤1 month], infants [>1-≤6 months], toddlers [>6 months-≤2 years], young children [>2-≤6 years], children [>6-≤12 years], adolescents [>12-≤18 years]), and six adult (19-45 years) subjects. Plasma spiked with apixaban 0 (baseline), 30, or 110 ng/ml was analysed for anti-factor Xa activity, factor X levels, prothrombin time (PT), and modified PT (mPT)...
May 24, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28530217/-phonosurgical-methods-of-treatment-in-unilateral-vocal-folds-paralysis
#5
REVIEW
Bozena Kosztyła-Hojna, Greta Berger, Maciej Zdrojkowski
Glottal insufficiency (GI) is a cause of breathy voice that can profoundly affect quality of voice. Main causes are unilateral vocal fold paralysis or endoscopic cordectomy for the early treatment of laryngeal cancer of the glottis. The main strategy in surgical treatment is type I medialization thyroplasty according to Isshiki with the use of implants e.g. silastic, hydroxyapatite, titanium, Gore-Tex or Montgomery. Other procedures are arytenoid adduction, the injection laryngoplasty via thyrohyoid and cricothyroid approach and laryngeal reinnervation...
April 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28526197/towards-a-quantitative-indicator-of-feather-disruption-following-the-cleansing-of-oiled-birds
#6
Stephen W Bigger, Lawrence N Ngeh, Peter Dann, John D Orbell
A computer-based imaging method for determining feather microstructure coherency following a cleansing treatment, was developed, calibrated and trialled on Mallard Duck (Anas platyrhyhchos) feathers. The feathers were initially contaminated with a light crude oil and then cleansed by either detergent (Deacon 90) treatment or, alternatively, by magnetic particle technology (MPT) using iron powder. The imaging method provides a single quantitative parameter for the coherence of feather microstructure and the results confirm that MPT treatment imparts less disruption to the feather microstructure than detergent treatment...
May 16, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28508921/latent-factor-structure-of-a-behavioral-economic-marijuana-demand-curve
#7
Elizabeth R Aston, Samantha G Farris, James MacKillop, Jane Metrik
RATIONALE: Drug demand, or relative value, can be assessed via analysis of behavioral economic purchase task performance. Five demand indices are typically obtained from drug purchase tasks. OBJECTIVES: The goal of this research was to determine whether metrics of marijuana reinforcement from a marijuana purchase task (MPT) exhibit a latent factor structure that efficiently characterizes marijuana demand. METHODS: Participants were regular marijuana users (n = 99; 37...
May 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28502878/the-relationship-between-sensory-loss-and-persistent-pain-1-year-after-breast-cancer-surgery
#8
Kenneth Geving Andersen, Helle Molter Duriaud, Henrik Kehlet, Eske Kvanner Aasvang
Moderate-to-severe persistent pain after breast cancer surgery (PPBCS) affects 10-20% of the patients. Sensory dysfunction is often concomitantly present suggesting a neuropathic pain state. The relationship between various postoperative pain states and sensory dysfunction has been examined by quantitative sensory testing (QST), but only 2 smaller studies have examined PPBCS and sensory dysfunction in the surgical area. The purpose of this prospective study was to assess the relative importance of sensory function and PPBCS...
May 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28496338/the-voice-quality-after-laser-surgery-versus-radiotherapy-of-t1a-glottic-carcinoma-systematic-review-and-meta-analysis
#9
Guanjiang Huang, Mengsi Luo, Jingxuan Zhang, Hongbing Liu
BACKGROUND AND OBJECTIVES: The voice quality assessment of laser surgery (LS) in comparison with radiotherapy (RT) remains uncertain in T1a glottic carcinoma treatment. This systematic review and meta-analysis were conducted to compare the voice quality of the two treatments. METHODS: Searches were conducted in PubMed, EMBASE, and Cochrane with the following index words: glotti*, layn*, vocal cord, vocal, surgery, cordectomy, laser, radiation, irradiation, radiotherapy, cancer, and carcinoma for relative studies that compared the voice quality between LS and RT...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28494457/resveratrol-protects-against-pulmonary-arterial-hypertension-in-rats-via-activation-of-silent-information-regulator-1
#10
Lei Yu, Yingfeng Tu, Xueling Jia, Kun Fang, Li Liu, Lin Wan, Chuanying Xiang, Yanan Wang, Xiangju Sun, Tianyou Liu, Dejun Yu, Weiwei Cao, Yinli Song, Yuhua Fan
BACKGROUND/OBJECTIVES: The polyphenol resveratrol (Rev) has been found to exhibit various beneficial effects including prevention of pulmonary arterial hypertension (PAH). The present study was designed to investigate the action and potential mechanism of Rev on PAH, focusing on the role of SIRT1 (Silent Information Regulator 1) in apoptosis of pulmonary artery smooth muscle cells (PASMCs). METHODS: PAH rats were established by exposure to hypoxia for 21 days. Rev and SRT1720 (a selective SIRT1 activator) were used to reverse PAH by gavaging rats...
May 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28485294/medialization-thyroplasty-in-glottis-insufficiency-due-to-unilateral-vocal-fold-paralysis-and-after-laser-cordectomies-preliminary-report
#11
Anna Rzepakowska, Ewa Osuch-Wójcikiewicz, Ewelina Sielska-Badurek, Kazimierz Niemczyk
Medialization thyroplasty (type I) is surgical procedure performed on the thyroid cartilage. The major indication for this surgery is significant glottis insufficiency due to unilateral vocal fold paresis. However the proce¬dure is also performed after vocal fold resections during cordectomy. THE AIM: The evaluation of voice results in patients after medialisation throplasty. MATERIAL AND METHODS: In Otolaryngology Department of Medical University of Warsaw there were performed so far 8 thyroplasty procedures under local anaesthesia with implantation of medical silicon protesis...
February 28, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28472867/effects-of-whey-and-soy-protein-addition-on-bread-rheological-property-of-wheat-flour
#12
Jianmin Zhou, Junfei Liu, Xiaozhi Tang
The development of wheat-based foods that are enriched with proteins is increasingly popular due to consumer demand regarding food nutritional content and quality. This study was performed to compare the effect of whey and soy protein on the rheological properties of wheat dough and bread-making quality in a relatively wide range of protein addition (0-30%). We found that the incorporation of whey protein (WP) decreased dough stability time (MST), minimum torque (MMT), G' and G", but increased dough peak torque (MPT), stickiness, G' and G" in temperature sweep...
May 4, 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28445711/the-short-term-behavioural-response-of-sows-but-not-gilts-to-a-social-stimulus-is-related-to-sow-aggressiveness-in-groups
#13
M Verdon, R S Morrison, M Rice, K L Butler, P H Hemsworth
This study examined relationships between the behavioural response of pregnant gilts (n=200, gestation 1) and sows (n=200, gestation 2) to a live, similarly-aged female pig (unfamiliar pig test, UPT) and to a fibre-glass model pig (model pig test, MPT), and aggressive behaviour on the day after mixing (day 2). Sows with a short latency to make contact with an unfamiliar sow in the UPT were more likely to deliver high levels of aggression at day 2 of gestation 2 (P=0.005), but this relationship was stronger when a model pig was used (P<0...
April 23, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28439206/is-operavox-a-clinically-useful-tool-for-the-assessment-of-voice-in-a-general-ent-clinic
#14
Richard Teck Kee Siau, Jay Goswamy, Sue Jones, Sadie Khwaja
BACKGROUND: Objective acoustic analysis is a key component of multidimensional voice assessment. OperaVOX is an iOS app which has been shown to be comparable to Multi Dimensional Voice Program for most principal measures of vocal function. As a relatively cheap, portable and easily accessible form of acoustic analysis, OperaVOX may be more clinically useful than laboratory-based software in many situations. This study aims to determine whether correlation exists between acoustic measurements obtained using OperaVOX, and perceptual evaluation of voice...
2017: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/28437507/effects-of-experimental-pain-and-lidocaine-on-mechanical-somatosensory-profile-and-face-perception
#15
Yuri Martins Costa, Eduardo E Castrillon, Leonardo Rigoldi Bonjardim, Paulo César Rodrigues Conti, Lene Baad-Hansen, Peter Svensson
AIMS: To assess the effects of experimental muscle pain and topical lidocaine applied to the skin overlying the masseter muscle on the mechanical somatosensory profile and face perception of the masseter muscle in healthy participants. METHODS: A total of 28 healthy participants received a 45-minute application of a lidocaine or placebo patch to the skin overlying the masseter muscle followed by one injection of 0.2 mL sterile solution of monosodium glutamate. Measurements were taken four times during each session of quantitative sensory testing (QST) (T0 = baseline, T1 = 45 minutes after patch application, T2 = immediately after glutamate injection, and T3 = 25 minutes after the glutamate injection), and the following variables were measured: mechanical detection threshold (MDT), mechanical pain threshold (MPT), pressure pain threshold (PPT), pain report (pain on palpation, pain spreading on palpation, and pain intensity), pain drawing, and perceptual distortion...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28427269/spatially-selective-binding-of-green-fluorescent-protein-on-designed-organosilane-nanopatterns-prepared-with-particle-lithography
#16
Zachary L Highland, Jayne C Garno
A practical approach for preparing protein nanopatterns has been to design surface templates of nanopatterns of alkanethiols or organosilanes that will selectively bind and localize the placement of biomolecules. Particle lithography provides a way to prepare millions of protein nanopatterns with a few basic steps. For our nanopatterning strategy, organosilanes with methoxy and sulfhydryl groups were chosen as a surface template. Green fluorescent protein (GFP) was selected as a model for patterning. Areas of 2-[methoxy (polyethyleneoxy)6-9propyl]trichlorosilane (MPT-silane) are effective as a matrix for resisting the attachment of proteins, whereas nanopatterns with sulfur groups provide reactive sites for binding linker groups to connect proteins...
April 19, 2017: Biointerphases
https://www.readbyqxmd.com/read/28424622/pravastatin-chronic-treatment-sensitizes-hypercholesterolemic-mice-muscle-to-mitochondrial-permeability-transition-protection-by-creatine-or-coenzyme-q10
#17
Estela N B Busanello, Ana C Marques, Noelia Lander, Diogo N de Oliveira, Rodrigo R Catharino, Helena C F Oliveira, Anibal E Vercesi
Statins are efficient cholesterol-lowering medicines utilized worldwide. However, 10% of patients suffer from adverse effects specially related to skeletal muscle function. Pro- or anti-oxidant effects of statins have been reported. Here we hypothesized that statins induce muscle mitochondrial oxidative stress leading to mitochondrial permeability transition (MPT) which may explain statin muscle toxicity. Thus, our aims were to investigate the effects of statin chronic treatment on muscle mitochondrial respiration rates, MPT and redox state indicators in the context of hypercholesterolemia...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28419085/neonatal-outcomes-of-moderatelyly-preterm-infants-compared-to-extremely-preterm-infants
#18
Michele C Walsh, Edward F Bell, Sarah Kandefer, Shampa Saha, Waldemar A Carlo, Carl T D'Angio, Abbot R Laptook, Pablo J Sanchez, Barbara J Stoll, Seetha Shankaran, Krisa P Van Meurs, Noah Cook, Rosemary D Higgins, Abhik Das, Nancy S Newman, Kurt Schibler, Barbara Schmidt, C Michael Cotten, Brenda B Poindexter, Kristi L Watterberg, William E Truog
BACKGROUND: Extremely preterm infants (EPT, <29 weeks' gestation) represent only 0.9% of births in the U.S., yet these infants are focus of most published research. Moderately preterm neonates (MPT, 29-33(6/7) weeks), are an understudied group of high-risk infants. METHODS: Objective: To determine the neonatal outcomes of MPT across the gestational age spectrum, and to compare these to EPT. A prospective observational cohort was formed in 18 Level 3-4 NICUs in the Eunice Kennedy Shriver NICHD Neonatal Research Network...
April 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28417285/alcohol-and-thiamine-deficiency-trigger-differential-mitochondrial-transition-pore-opening-mediating-cellular-death
#19
REVIEW
Abdoulaye Bâ
Accumulating evidence has shown that binge-type alcohol intake in mothers interferes with thiamine deficiency (TD) to promote the fetal alcohol syndrome (FAS). Developmental alcohol or TD exposures act either synergistically or separately to reproduce FAS features e.g. intrauterine growth retardation and related microcephaly characterized by extensive cellular death induced by one another neurotoxicant. However molecular and cellular mechanisms underlying apoptosis in both alcohol and TD toxicities are unknown...
June 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28402088/the-mozart-study-a-relation-between-dynamic-hyperinflation-and-physical-activity-in-patients-with-chronic-obstructive-pulmonary-disease
#20
R W van Leuteren, S Dijkhuis, F H C de Jongh, P D L P M van der Valk, M Tabak, M G J Brusse-Keizer
BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) experience dyspnoea during exercise, resulting in a reduction of physical activity (PA). Dynamic hyperinflation (DH) is seen as a major cause of dyspnoea in COPD. OBJECTIVE: The objective of the current study was to investigate the relationship between DH, in terms of the amount of DH and the development and recovery rate of DH in patients with COPD, and PA. METHODS: Thirty-five patients with stable COPD were included from an outpatient clinic (14 GOLD II and 21 GOLD III, median age 65)...
April 12, 2017: Clinical Physiology and Functional Imaging
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