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https://www.readbyqxmd.com/read/28098827/shared-sulfur-mobilization-routes-for-trna-thiolation-and-molybdenum-cofactor-biosynthesis-in-prokaryotes-and-eukaryotes
#1
REVIEW
Silke Leimkühler, Martin Bühning, Lena Beilschmidt
Modifications of transfer RNA (tRNA) have been shown to play critical roles in the biogenesis, metabolism, structural stability and function of RNA molecules, and the specific modifications of nucleobases with sulfur atoms in tRNA are present in pro- and eukaryotes. Here, especially the thiomodifications xm⁵s²U at the wobble position 34 in tRNAs for Lys, Gln and Glu, were suggested to have an important role during the translation process by ensuring accurate deciphering of the genetic code and by stabilization of the tRNA structure...
January 14, 2017: Biomolecules
https://www.readbyqxmd.com/read/28093616/rare-germline-alterations-in-cancer-related-genes-associated-with-the-risk-of-multiple-primary-tumor-development
#2
Rolando A R Villacis, Tatiane R Basso, Luisa M Canto, Maísa Pinheiro, Karina M Santiago, Juliana Giacomazzi, Cláudia A A de Paula, Dirce M Carraro, Patrícia Ashton-Prolla, Maria I Achatz, Silvia R Rogatto
: Multiple primary tumors (MPT) have been described in carriers of inherited cancer predisposition genes. However, the genetic etiology of a large proportion of MPT cases remains unclear. We reviewed 267 patients with hereditary cancer predisposition syndromes (HCPS) that underwent genetic counseling and selected 22 patients with MPT to perform genomic analysis (CytoScan HD Array, Affymetrix) aiming to identify new alterations related to a high risk of developing MPT. Twenty patients had a positive family history of cancer and 11 met phenotypic criteria for HCPS...
January 16, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28092530/feasibility-of-multi-plane-transmit-beamforming-for-real-time-volumetric-cardiac-imaging-a-simulation-study
#3
Yinran Chen, Ling Tong, Alejandra Ortega, Jianwen Luo, Jan D'hooge
Today's three-dimensional (3-D) cardiac ultrasound imaging systems suffer from relatively low spatial and temporal resolution, limiting their applicability in daily clinical practice. To address this problem, 3-D diverging wave imaging with spatial coherent compounding (DWC) as well as 3-D multi-line-transmit (MLT) imaging have recently been proposed. Currently, the former improves the temporal resolution significantly at the expense of image quality and the risk of introducing motion artifacts whereas the latter only provides a moderate gain in volume rate but mostly preserves quality...
January 10, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28079362/intensive-study-on-catalytical-behavior-of-n-methylphenothiazine-as-a-soluble-mediator-to-oxidize-li2o2-cathode-of-li-o2-battery
#4
Ningning Feng, Xiaowei Mu, Xueping Zhang, Ping He, Haoshen Zhou
Aprotic Li-O2 batteries have attracted worldwide interest owing to their ultra-high theoretical energy density. However, the practical Li-O2 batteries still suffer from high charge overpotential and low energy efficiency resulting from the sluggish kinetics in electrochemically oxidizing the insulating lithium peroxide (Li2O2). Recently, dissolved redox mediators in the electrolyte have enabled the effective catalytic oxidation of Li2O2 at the liquid-solid interface. Here, we report that the incorporation of N-methylphenothiazine (MPT), as a redox shuttle in Li-O2 batteries, provides a dramatic reduction in charge overpotential to 0...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28078995/sphingolipids-in-genetic-and-acquired-forms-of-chronic-kidney-diseases
#5
Norishi Ueda
Sphingolipids (SLs) regulate apoptosis, proliferation, and stress response. SLs, including ceramide, glycosphingolipids (glucosylceramide, lactosylceramide, and gangliosides) and sphingosine-1-phosphate (S1P), play a role in the pathogenesis and progression of genetic (lysosomal storage disease, congenital nephrotic syndrome and polycystic kidney disease) and non-genetic forms of chronic kidney diseases (CKDs). SLs metabolism defects promote complications (cardiovascular events, etc.) via oxidant stress in CKDs...
January 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28068367/cell-surface-integrins-and-car-are-both-essential-for-adenovirus-type-5-transduction-of-canine-cells-of-lymphocytic-origin
#6
Payal Agarwal, Elizabeth A Gammon, Abdul Mohin Sajib, Maninder Sandey, Bruce F Smith
Adenoviruses are the most widely used vectors in cancer gene therapy. Adenoviruses vectors are well characterized and are easily manipulated. Adenovirus serotype 5 (Ad5) is the most commonly used human serotype. Ad5 internalization into host cells is a combined effect of binding of Ad5 fiber knob with the coxsackie virus and adenovirus receptor (CAR) and binding of RGD motifs in viral penton to cell surface integrins (αvβ3, αvβ5). Ad5's wide range of host-cell transduction and lack of integration into the host genome have made it an excellent choice for cancer therapeutics...
2017: PloS One
https://www.readbyqxmd.com/read/28060335/identification-of-intracellular-signaling-events-induced-in-viable-cells-by-interaction-with-neighboring-cells-undergoing-apoptotic-cell-death
#7
Snezana Vujicic, Lanfei Feng, Angelika Antoni, Joyce Rauch, Jerrold S Levine
Cells dying by apoptosis, also referred to as regulated cell death, acquire multiple new activities that enable them to influence the function of adjacent live cells. Vital activities, such as survival, proliferation, growth, and differentiation, are among the many cellular functions modulated by apoptotic cells. The ability to recognize and respond to apoptotic cells appears to be a universal feature of all cells, regardless of lineage or organ of origination. However, the diversity and complexity of the response to apoptotic cells mandates that great care be taken in dissecting the signaling events and pathways responsible for any particular outcome...
December 27, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28043587/cloning-expression-and-purification-of-recombinant-protein-mpt-64-from-a-virulent-strain-of-mycobacterium-bovis-in-a-prokaryotic-system
#8
Maryam Mohammadi Tashakkori, Majid Tebianian, Mohammad Tabatabaei, Nader Mosavari
OBJECTIVE: Tuberculosis (TB) is a zoonotic infectious disease common to humans and animals that is caused by the rod-shaped acid-fast bacterium Mycobacterium bovis. Rapid and sensitive detection of TB is promoted by specific antigens. Virulent strains of the TB complex from M. bovis contain 16 regions of difference (RD) in their genome that encode important proteins, including major protein of Mycobacterium Tuberculosis 64 (MBT-64, which is a primary immune-stimulating antigen encoded by RD-2...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28025692/age-related-differences-in-inhibitory-control-and-memory-updating-in-boys-with-asperger-syndrome
#9
Elisabeth M Weiss, Bianca Gschaidbauer, Liane Kaufmann, Andreas Fink, Günter Schulter, Erich Mittenecker, Ilona Papousek
Deficits in specific executive domains are highly prevalent in autism spectrum disorder; however, age-related improvements in executive functions (reflecting prefrontal maturational changes) have been reported even in individuals diagnosed with autism. The current study examined two components of cognitive flexibility (inhibition of prepotent responses and memory monitoring/updating) by using a random-motor-generation task (MPT) in a group of 23 boys with Asperger syndrome (AS) and 23 matched healthy controls...
December 26, 2016: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28017706/effect-of-unmodulated-5-khz-alternating-currents-versus-transcutaneous-electrical-nerve-stimulation-on-mechanical-and-thermal-pain-tactile-threshold-and-peripheral-nerve-conduction-a-double-blind-placebo-controlled-crossover-trial
#10
Juan Avendaño-Coy, Julio Gómez-Soriano, Carlos Goicoechea-García, Julian Angel Basco-López, Julian Taylor
OBJECTIVE: To investigate the effect of unmodulated 5-KHz alternating current on mechanical pain threshold (MPT), heat pain threshold (HPT), tactile threshold (TT), and peripheral nerve conduction (PNC) compared to TENS and sham stimulation SETTING: National referral center DESIGN: Randomised double-blind placebo controlled crossover trial. PARTICIPANTS: Thirty-eight healthy volunteers. No dropouts or adverse events were reported. INTERVENTION: TENS, unmodulated 5-KHz currents, and sham stimulation were applied on the radial nerve for 20 minutes with a 24-hour washout period between them and concealed intervention allocation...
December 22, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28009310/-the-early-diagnostics-of-multiple-primary-tumors-of-male-urogenital-tract-review-of-clinical-cases
#11
A Khachatryan
Multiple primary tumors (MPT) or polyneoplasias significance is very important. MTP are met rarely in male urogenital system; only single cases are described in the literature. Nevertheless, during the last years there has been an increase of their frequency. So, in order to understand are urogenital MPT popular in men, what is the connection between their appearance and whether there is a trend of increase or not, we have decided to investigate the cases histories of 272 oncourological patients between 18-84 years old have been studied in the period of 2013 - 2015...
November 2016: Georgian Medical News
https://www.readbyqxmd.com/read/28008644/test-retest-reliability-of-quantitative-sensory-testing-for-mechanical-somatosensory-and-pain-modulation-assessment-of-masticatory-structures
#12
Yuri M Costa, Orlando Morita-Neto, Everardo N S de Araújo-Júnior, Fernanda A Sampaio, Paulo César R Conti, Leonardo R Bonjardim
BACKGROUND: Assessing the reliability of medical measurements is a crucial step toward the elaboration of an applicable clinical instrument. There are few studies that evaluate the reliability of somatosensory assessment and pain modulation of masticatory structures. OBJECTIVES: To estimate the test-retest reliability, i.e., over time, of the mechanical somatosensory assessment of anterior temporalis, masseter and temporomandibular joint (TMJ) and the conditioned pain modulation (CPM) using the anterior temporalis as the test site...
December 23, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28007508/functional-assessment-of-glottal-insufficiency-treated-by-hyaluronic-acid-injection-retrospective-20-case-series
#13
C Dorbeau, F Marmouset, E Lescanne, D Bakhos, S Morinière
OBJECTIVES: The objectives of the present study were to describe hyaluronic acid injection to the vocal folds as treatment for glottal insufficiency, assess indications and report vocal results at 1 month and later than 6 months postoperatively. PATIENTS AND METHODS: A single-center retrospective study was performed for the period March 2012 to August 2015. Inclusion criteria comprised: unilateral recurrent nerve palsy or vocal fold closure defect with conserved mobility...
December 19, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27951424/the-effects-of-perceived-quality-on-behavioral-economic-demand-for-marijuana-a-web-based-experiment
#14
Paula C Vincent, R Lorraine Collins, Liu Liu, Jihnhee Yu, Joseph A De Leo, Mitch Earleywine
BACKGROUND: Given the growing legalization of recreational marijuana use and related increase in its prevalence in the United States, it is important to understand marijuana's appeal. We used a behavioral economic (BE) approach to examine whether the reinforcing properties of marijuana, including "demand" for marijuana, varied as a function of its perceived quality. METHODS: Using an innovative, Web-based marijuana purchase task (MPT), a sample of 683 young-adult recreational marijuana users made hypothetical purchases of marijuana across three qualities (low, mid and high grade) at nine escalating prices per joint, ranging from $0/free to $20...
January 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27941166/study-of-commonly-used-organophosphate-pesticides-that-induced-oxidative-stress-and-apoptosis-in-peripheral-blood-lymphocytes-of-rats
#15
A Ojha, Y K Gupta
In a previous study, we have found that organophosphate (OP) pesticides such as chlorpyrifos (CPF), methyl parathion (MPT), and malathion (MLT) significantly induced genotoxicity in peripheral blood lymphocytes of rats. To explore the mechanism of OP-induced genotoxicity, we measured the formation of DNA interstrand cross-links (DICs) and apoptosis in peripheral blood lymphocytes of rats. Peripheral blood lymphocytes of rats were treated with CPF, MPT, and MLT individually and in combination at concentrations of 0...
December 9, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27931522/effectiveness-of-fibrin-coating-in-the-management-of-web-formation-after-laryngomicrosurgery
#16
REVIEW
K Adachi, T Umezaki
PURPOSE: To explore the effectiveness of fibrin coating in reducing web formation after endoscopic management of the anterior commissure of the larynx. MATERIALS AND METHODS: Using a spray device that is generally used for laparoscopic operations, we covered the wound with fibrin glue (Bolheal®) to avoid web formation. This technique was employed in cases wherein the anterior commissure was mainly managed by laser operation; the glue was sprayed after vaporization...
January 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27913929/-inpatient-multimodal-pain-therapy-additive-value-of-neuromuscular-core-stability-exercises-for-chronic-back-pain
#17
F Giesche, H Streicher, M Maiwald, P Wagner
INTRODUCTION: The medical and healthcare economic burden caused by chronic lumbar back pain (CLBP) requires the use of interdisciplinary treatment approaches. The present study aimed to evaluate whether the effectiveness of inpatient multimodal pain therapy (MPT, operations and procedures (OPS) coding 8-918.02), can be increased by implementing additional neuromuscular core stability exercises (NCSE). MATERIAL AND METHODS: As part of a prospective controlled study, subjects with CLBP (n = 48, 17 males, 58...
December 2, 2016: Der Schmerz
https://www.readbyqxmd.com/read/27907136/immune-activation-and-bacterial-translocation-a-link-between-impaired-immune-recovery-and-frequent-visceral-leishmaniasis-relapses-in-hiv-infected-patients
#18
Maria Luciana Silva-Freitas, Glaucia Fernandes Cota, Talia S Machado-de-Assis, Carmem Giacoia-Gripp, Ana Rabello, Alda M Da-Cruz, Joanna R Santos-Oliveira
The maintenance of chronic immune activation due to leishmaniasis or even due to microbial translocation is associated with immunosenescence and may contribute to frequent relapses. Our aim was to investigate whether patients with HIV-associated visceral leishmaniasis (VL/HIV) who experience a single episode of VL have different immunological behaviors in comparison to those who experience frequent relapses. VL/HIV patients were allocated to non-relapsing (NR, n = 6) and relapsing (R, n = 11) groups and were followed from the active phase of VL up to 12 months post-treatment (mpt)...
2016: PloS One
https://www.readbyqxmd.com/read/27906465/repeated-famotidine-administration-results-in-a-diminished-effect-on-intragastric-ph-in-dogs
#19
M K Tolbert, A Graham, A Odunayo, J Price, J M Steiner, K Newkirk, S Hecht
BACKGROUND: Famotidine is an acid suppressant commonly administered to dogs. Prolonged famotidine use in people results in decreased efficacy, but the effect in dogs is unknown. HYPOTHESIS/OBJECTIVES: To compare the effect of repeated oral administration of famotidine or placebo on intragastric pH and serum gastrin in dogs. We hypothesized that famotidine would have a diminished effect on intragastric pH on day 13 compared to day 1. ANIMALS: Six healthy adult colony Beagles...
December 1, 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27902763/temperature-shift-alters-dna-methylation-and-histone-modification-patterns-in-gonadal-aromatase-cyp19a1-gene-in-species-with-temperature-dependent-sex-determination
#20
Yuiko Matsumoto, Brette Hannigan, David Crews
The environment surrounding the embryos has a profound impact on the developmental process and phenotypic outcomes of the organism. In species with temperature-dependent sex determination, gonadal sex is determined by the incubation temperature of the eggs. A mechanistic link between temperature and transcriptional regulation of developmental genes, however, remains elusive. In this study, we examine the changes in DNA methylation and histone modification patterns of the aromatase (cyp19a1) gene in embryonic gonads of red-eared slider turtles (Trachemys scripta) subjected to a temperature shift during development...
2016: PloS One
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