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https://www.readbyqxmd.com/read/28088773/epidemiology-and-outcome-of-acute-pancreatitis-in-end-stage-renal-disease-dialysis-patients-a-10-year-national-cohort-study
#1
Hung-Jui Chen, Jhi-Joung Wang, Wen-Ing Tsay, Shwu-Huey Her, Cheng-Heng Lin, Chih-Chiang Chien
BACKGROUND: The objective of this study is to determine the incidence and severity of acute pancreatitis (AP) in patients with end-stage renal disease (ESRD) on dialysis and whether the dialysis modality [hemodialysis (HD) versus peritoneal dialysis (PD)] confers a higher risk for AP as well as complications or mortality related to AP. METHODS: We analyzed national health insurance claims data of 67 078 ESRD patients initiating dialysis between 1999 and 2007 in Taiwan...
January 14, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28066847/an-efficient-ugi-3cr-aza-diels-alder-pomeranz-fritsch-protocol-towards-novel-aza-analogues-of-%C3%A2-nuevamine-%C3%A2-lennoxamine-and-magallanesine-a-diversity-oriented-synthesis-approach
#2
Óscar Vázquez-Vera, Jorge S Sánchez-Badillo, Alejandro Islas-Jácome, Manuel A Rentería-Gómez, Shrikant G Pharande, Carlos J Cortes-García, Mónica A Rincón-Guevara, Ilich A Ibarra, Rocío Gámez-Montaño, Eduardo González-Zamora
A rapid and efficient synthesis of a series of (±)-nuevamine, (±)-lennoxamine and magallanesine aza analogues is described. The synthetic strategy involves Ugi-3CR and two further condensation processes, aza-Diels-Alder cycloaddition and the Pomeranz-Fritsch reaction. The variation of the chain-size in aldehyde moieties provided structural diversity in only two operational reaction steps.
January 9, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28050248/management-of-achalasia-in-the-uk-do-we-need-new-guidelines
#3
REVIEW
Jihene El Kafsi, Antonio Foliaki, Thomas C B Dehn, Nicholas D Maynard
AIM: It is recommended that management of complex benign upper gastrointestinal pathology is discussed at multi disciplinary team (MDT) meetings. American College of Gastroenterology (ACG) guidelines further recommend that treatment delivery is provided by high volume centres, with objective post-procedural investigations, in order to improve patient outcomes. We aimed to survey the current UK practice in the management of achalasia. METHODS: 443 Upper gastrointestinal (UGI) specialist surgeons throughout the UK were sent a surveymonkey...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28032204/gastrointestinal-bleeding-due-to-gastrointestinal-tract-malignancy-natural-history-management-and-outcomes
#4
Richard A Schatz, Don C Rockey
BACKGROUND: Gastrointestinal (GI) tumor bleeding can vary from occult bleeding to massive hemorrhage and can be the presenting sign of malignancy. AIMS: Our primary aims were to: (1) characterize the natural history, treatment, and outcomes in patients with GI tumor bleeding and (2) compare and contrast bleeding in upper GI (UGI)/small bowel (SB) and lower GI malignancies. METHODS: Patients with endoscopically confirmed tumor bleeding were identified through search of consecutive electronic medical records: Bleeding was determined by the presence of melena, hematochezia, hematemesis, or fecal occult blood...
December 28, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28029601/hypothalamic-amp-activated-protein-kinase-regulates-biphasic-insulin-secretion-from-pancreatic-%C3%AE-cells-during-fasting-and-in-type-2-diabetes
#5
Shinji Kume, Motoyuki Kondo, Shiro Maeda, Yoshihiko Nishio, Tsuyoshi Yanagimachi, Yukihiro Fujita, Masakazu Haneda, Keiko Kondo, Akihiro Sekine, Shin-Ich Araki, Hisazumi Araki, Masami Chin-Kanasaki, Satoshi Ugi, Daisuke Koya, Sawako Kitahara, Kiyosumi Maeda, Atsunori Kashiwagi, Takashi Uzu, Hiroshi Maegawa
Glucose-stimulated insulin secretion (GSIS) by pancreatic β cells is biphasic. However, the physiological significance of biphasic GSIS and its relationship to diabetes are not yet fully understood. This study demonstrated that impaired first-phase GSIS follows fasting, leading to increased blood glucose levels and brain glucose distribution in humans. Animal experiments to determine a possible network between the brain and β cells revealed that fasting-dependent hyperactivation of AMP-activated protein kinase in the hypothalamus inhibited first-phase GSIS by stimulating the α-adrenergic pancreatic nerve...
October 28, 2016: EBioMedicine
https://www.readbyqxmd.com/read/28012332/laparoscopic-management-of-severe-reflux-after-sleeve-gastrectomy-using-the-linx-%C3%A2-system-technique-and-one-year-follow-up-case-report
#6
Abdelkader Hawasli, Mark Tarakji, Moayad Tarboush
INTRODUCTION: Management of severe reflux after sleeve gastrectomy (SG) usually requires converting to Roux-en-y gastric bypass (RYGB). We present a case of managing this problem using the LINX(®) system. PRESENTATION OF CASE: In February 2015, we performed a laparoscopic placement of LINX(®) system to treat severe reflux after sleeve gastrectomy on a 25-year-old female. The operative time was 47min. There were no intra or postoperative complications. The hospital stay was one day...
November 29, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28005533/hypothalamic-amp-activated-protein-kinase-regulates-biphasic-insulin-secretion-from-pancreatic-cells-during-fasting-and-in-type-2-diabetes
#7
Shinji Kume, Motoyuki Kondo, Shiro Maeda, Yoshihiko Nishio, Tsuyoshi Yanagimachi, Yukihiro Fujita, Masakazu Haneda, Keiko Kondo, Akihiro Sekine, Shin-Ich Araki, Hisazumi Araki, Masami Chin-Kanasaki, Satoshi Ugi, Daisuke Koya, Sawako Kitahara, Kiyosumi Maeda, Atsunori Kashiwagi, Takashi Uzu, Hiroshi Maegawa
Glucose-stimulated insulin secretion (GSIS) by pancreatic ? cells is biphasic. However, the physiological significance of biphasic GSIS and its relationship to diabetes are not yet fully understood. This study demonstrated that impaired first-phase GSIS follows fasting, leading to increased blood glucose levels and brain glucose distribution in humans. Animal experiments to determine a possible network between the brain and ? cells revealed that fasting-dependent hyperactivation of AMP-activated protein kinase in the hypothalamus inhibited first-phase GSIS by stimulating the ?-adrenergic pancreatic nerve...
November 2016: EBioMedicine
https://www.readbyqxmd.com/read/27994697/acute-reversible-duodenitis-following-non-therapeutic-upper-gastrointestinal-endoscopy-is-duodenal-diverticulum-a-predisposing-factor
#8
Emre Unal, Elif Nurbegum Ayan, Sibel Yazgan
BACKGROUND: Diagnostic upper gastrointestinal (UGI) endoscopy has been regarded as a safe procedure. CASE REPORT: We report of a 67-year-old woman who developed epigastric pain and dyspeptic complaints following an uneventful upper gastrointestinal endoscopy. The diagnosis of an acute reversible duodenitis was made on the basis of imaging studies. A duodenal diverticulum was also found on CT images, which raised the suspicion that duodenal diverticulum could be a predisposing factor for duodenitis...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27935911/giant-left-atrium-a-rare-case-of-acute-upper-gastrointestinal-bleeding
#9
K R Dewan, B S Patowary, S Bhattarai
Acute upper GI bleeding is a common medical emergency with a hospital mortality of approximately 10%. Non variceal UGI bleeding is the most common cause followed by oesophageal varices. Various rare causes have been described in the literature but there are very few cases of giant left atrium leading to oesophageal erosion and causing upper GI bleeding. We are presenting a case of rheumatic valvular heart disease with giant left atrium who presented in our department with acute upper GI bleeding.
January 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27921386/cytotoxicity-of-a-series-of-norcantharidin-inspired-tetrahydroepoxyisoindole-carboxamides
#10
Lawson K Spare, Pasquale Falsetta, Jayne Gilbert, David G Harman, Mark A Baker, Feng Li, Adam McCluskey, Jack K Clegg, Jennette A Sakoff, Janice R Aldrich-Wright, Christopher P Gordon
A series of 28 norcantharidin (NorC)-inspired analogues were accessed via a robust two-step Ugi intramolecular Diels-Alder (IMDA) sequence. Four analogues displayed whole-cell cytotoxicity equipotent to that of NorC and cisplatin against a number of cancer cell lines and a normal breast cell line (MCF10A). Notably, (3S,3aS,6R)-2-benzyl-7-methyl-N-(naphthalen-2-yl)-1-oxo-1,2,3,6-tetrahydro-3a,6-epoxyisoindole-3-carboxamide (trans-27) displayed superior whole-cell activity against breast (MCF-7, GI50 =2.9 μm) and colon (HT29, GI50 =6...
December 6, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27914800/discovery-of-a-new-isomannide-based-peptidomimetic-synthetized-by-ugi-multicomponent-reaction-as-human-tissue-kallikrein-1-inhibitor
#11
Thalita G Barros, Jorge A N Santos, Bruno E G de Souza, Ana Carolina R Sodero, Alessandra M T de Souza, Dayane P da Silva, Carlos Rangel Rodrigues, Sergio Pinheiro, Luiza R S Dias, Bárbara Abrahim-Vieira, Luciano Puzer, Estela M F Muri
Human kallikrein 1 (KLK1) is the most extensively studied member of this family and plays a major role in inflammation processes. From Ugi multicomponent reactions, isomannide-based peptidomimetic 10 and 13 where synthesized and showed low micromolar values of IC50 for KLK1 The most active compound (10) presented competitive mechanism, with three structural modifications important to interact with active site residues which corroborates its KLK1 inhibition. Finally, the most active compound also showed good ADMET profile, which indicates compound 10 as a potential hit in the search for new KLK1 inhibitors with low side effects...
January 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27910982/synthesis-of-6-methyl-3-4-dihydropyrazinones-using-an-ugi-4-cr-allenamide-cycloisomerization-protocol
#12
Estefanía Icelo-Ávila, Yoarhy A Amador-Sánchez, Luis A Polindara-García, Luis D Miranda
A synthetic approach to the 6-methyl-3,4-dihydropyrazinone core from Ugi adducts is described. This methodology relies on the regioselective C-N bond formation between an allenamide moiety at C-β and an amide anion formed under base-mediated conditions. This protocol allows easy access to tricyclic systems such as pyrazino[2,1-a]isoindole and pyrazino[2,1-a]isoquinoline nuclei.
December 2, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27898350/cronkhite-canada-syndrome-complicated-by-pulmonary-embolism-a-case-report
#13
Neha L Nemade, Urvi B Shukla, Gajanan D Wagholikar
INTRODUCTION: Cronkhite Canada Syndrome (CCS) is a rare syndrome, described in 1955 by Americans, Leonard Wolsey Cronkhite and Wilma Jeanne Canada in the New England Journal of Medicine [1]. About 450 cases have been reported. Complications, like malignant transformation, unprovoked thromboembolism is known. Since there is wide variability in medical presentation, no definitive diagnostic and treatment protocol s have been set. The mortality remains at 55%. CASE PRESENTATION: We report a case of a 50 year old male patient presenting with diarrhea, weight loss, abdominal pain, ectodermal features...
November 17, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27878155/spin-labelled-diketopiperazines-and-peptide-peptoid-chimera-by-ugi-multi-component-reactions
#14
Haider N Sultani, Haleh H Haeri, Dariush Hinderberger, Bernhard Westermann
For the first time, spin-labelled coumpounds have been obtained by isonitrile-based multi component reactions (IMCRs). The typical IMCR Ugi-protocols offer a simple experimental setup allowing structural variety by which labelled diketopiperazines (DKPs) and peptide-peptoid chimera have been synthesized. The reaction keeps the paramagnetic spin label intact and offers a simple and versatile route to a large variety of new and chemically diverse spin labels.
December 28, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27869255/metal-catalyzed-c-h-functionalization-involving-isocyanides
#15
REVIEW
Bingrui Song, Bin Xu
Isocyanides have a broad range of applications in multicomponent reactions such as Passerini and Ugi processes. Recent advances in metal catalysis have tremendously increased the versatility of isocyanides in organic chemistry. Suitable metal catalysts could selectively activate various C-H bonds to allow direct functionalization under mild conditions, which represents a chemical process with broad synthetic potential. The synergy from the combination of isocyanide insertion and C-H bond activation offers an efficient and powerful tool to establish complicated reactions and to construct useful substances, from which the high potential of such strategy has been convincingly demonstrated in drug discovery, organic synthesis, and materials science...
November 21, 2016: Chemical Society Reviews
https://www.readbyqxmd.com/read/27848201/the-role-of-hemoglobin-laboratory-test-results-for-the-detection-of-upper-gastrointestinal-bleeding-outcomes-resulting-from-the-use-of-medications-in-observational-studies
#16
Elisabetta Patorno, Joshua J Gagne, Christine Y Lu, Kevin Haynes, Andrew T Sterrett, Jason Roy, Xingmei Wang, Marsha A Raebel
INTRODUCTION: The identification of upper gastrointestinal (UGI) bleeding and perforated ulcers in claims data typically relies on inpatient diagnoses. The use of hemoglobin laboratory results might increase the detection of UGI events that do not lead to hospitalization. OBJECTIVES: Our objective was to evaluate whether hemoglobin results increase UGI outcome identification in electronic databases, using non-steroidal anti-inflammatory drugs (NSAIDs) as a test case...
November 15, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27833405/efficacy-of-retrievable-metallic-stent-with-fixation-string-for-benign-stricture-after-upper-gastrointestinal-surgery
#17
Jeong-Eun Kim, Hyo-Cheol Kim, Myungsu Lee, Saebeom Hur, Minuk Kim, Sang Hwan Lee, Soo Buem Cho, Chan Sun Kim, Joon Koo Han
OBJECTIVE: To determine the efficacy of retrievable metallic stent with fixation string for benign anastomotic stricture after upper gastrointestinal (UGI) surgery. MATERIALS AND METHODS: From June 2009 to May 2015, a total of 56 retrievable metallic stents with fixation string were placed under fluoroscopy guidance in 42 patients who were diagnosed with benign anastomotic stricture after UGI surgery. Clinical success was defined as achieving normal regular diet (NRD)...
November 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/27829908/application-of-heterocyclic-aldehydes-as-components-in-ugi-smiles-couplings
#18
Katelynn M Mason, Michael S Meyers, Abbie M Fox, Sarah B Luesse
Efficient one-pot Ugi-Smiles couplings are reported for the use of furyl-substituted aldehyde components. In the presence of these heterocyclic aldehydes, reactions tolerated variations in amine components and led to either isolated N-arylamide Ugi-Smiles adducts or N-arylepoxyisoindolines, products of tandem Ugi-Smiles Diels-Alder cyclizations, in moderate yields. A thienyl-substituted aldehyde was also a competent component for Ugi-Smiles adduct formation.
2016: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27812289/concentrations-of-water-soluble-vitamins-in-blood-and-urinary-excretion-in-patients-with-diabetes-mellitus
#19
Hiromi Iwakawa, Yasuyuki Nakamura, Tomiho Fukui, Tsutomu Fukuwatari, Satoshi Ugi, Hiroshi Maegawa, Yukio Doi, Katsumi Shibata
We examined the concentrations of water-soluble vitamins in blood and urinary excretion of 22 patients with type 2 diabetes mellitus (type 2DM) and 20 healthy control participants. Macronutrient and vitamin intakes of type 2DM subjects were measured using a weighed food record method. Control participants consumed a semipurified diet for eight days. Multiple linear regression models were used to determine whether significant differences existed in vitamin concentrations in blood independent of age, sex, and other confounding factors...
2016: Nutrition and Metabolic Insights
https://www.readbyqxmd.com/read/27811012/her2-status-in-advanced-or-metastatic-gastric-esophageal-or-gastroesophageal-adenocarcinoma-for-entry-to-the-trio-013-logic-trial-of-lapatinib
#20
Michael F Press, Catherine E Ellis, Robert C Gagnon, Tobias J Grob, Marc Buyse, Ivonne Villalobos, Zhiyong Liang, Shafei Wu, Yung-Jue Bang, Shu-Kui Qin, Hyun Cheol Chung, Jianming Xu, Joon Oh Park, Krzysztof Jeziorski, Karen Afenjar, Yanling Ma, Monica C Estrada, Douglas M Robinson, Stefan J Scherer, Guido Sauter, J Randolph Hecht, Dennis J Slamon
HER2/ERBB2 status is used to select patients for HER2-targeted therapy. HER2/ERBB2 amplification/overexpression of upper gastrointestinal (UGI) adenocarcinomas was determined locally or in two central laboratories to select patients for the TRIO-013/LOGiC trial of chemotherapy with or without lapatinib. Patients selected locally had central laboratory confirmation of HER2 amplification for inclusion in the primary efficacy population. HER2 was assessed with PathVysion or IQ PharmDx FISH and HercepTest immunohistochemistry assays...
January 2017: Molecular Cancer Therapeutics
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