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https://www.readbyqxmd.com/read/28220986/boron-complexes-of-glyoxal-derived-ugi-adducts-as-a-new-class-of-photoluminescent-materials-featuring-aggregation-induced-emission
#1
Huiping Wei, Gaigai Wang, Yingchun Wang, Binbin Li, Jianjun Huang, Stepan Kashtanov, Kristof Van Hecke, Olga P Pereshivko, Vsevolod A Peshkov
A series of new O,O-chelated boron complexes was prepared through four-component Ugi reaction followed by the complexation of the resulting 1,3-dicarbonyl compounds with boron trifluoride diethyl etherate. The optical properties of these novel luminophores were investigated by UV-visible spectroscopy and spectrofluorometry and their aggregation-induced emission (AIE) behavior was revealed.
February 21, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28220702/n-hydroxyimide-ugi-reaction-toward-%C3%AE-hydrazino-amides
#2
Ajay L Chandgude, Alexander Dömling
The Ugi four-component reaction (U-4CR) with N-hydroxyimides as a novel carboxylic acid isostere has been reported. This reaction provides straightforward access to α-hydrazino amides. A broad range of aldehydes, amines, isocyanides and N-hydroxyimides were employed to give products in moderate to high yields. This reaction displays N-N bond formation by cyclic imide migration in the Ugi reaction. Thus, N-hydroxyimide is added as a new acid component in the Ugi reaction and broadens the scaffold diversity.
February 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/28211208/one-pot-assembly-of-amino-acid-bridged-hybrid-macromulticyclic-cages-through-multiple-multicomponent-macrocyclizations
#3
Ludger A Wessjohann, Oliver Kreye, Daniel G Rivera
An important development in the field of macrocyclization strategies towards molecular cages is described. The approach comprises the utilization of a double Ugi four-component macrocyclization for the assembly of macromulticycles with up to four different tethers, that is, hybrid cages. The innovation of this method rests on setting up the macromulticycle connectivities not through the tethers but through the bridgeheads, which in this case involve N-substituted amino acids. Both dilution and metal-template-driven macrocyclization conditions were implemented with success, enabling the one-pot formation of cryptands and cages including steroidal, polyether, heterocyclic, peptidic, and aryl tethers...
February 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28197734/non-canonical-amino-acids-bearing-thiophene-and-bithiophene-synthesis-by-an-ugi-multicomponent-reaction-and-studies-on-ion-recognition-ability
#4
Cátia I C Esteves, M Manuela M Raposo, Susana P G Costa
Novel thienyl and bithienyl amino acids with different substituents were obtained by a multicomponent Ugi reaction between a heterocyclic aldehyde, an amine, an acid and an isocyanide. Due to the presence of the sulphur heterocycle at the side chain, these unnatural amino acids are highly emissive and bear extra electron donating atoms so they were tested for their ability to act as fluorescent probes and chemosensors in the recognition of biomedically relevant ions in acetonitrile and acetonitrile/water solutions...
February 14, 2017: Amino Acids
https://www.readbyqxmd.com/read/28181791/two-cycles-with-one-catch-hydrazine-in-ugi-4-cr-and-its-post-cyclizations
#5
Yuanze Wang, Pravin Patil, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, Alexander Dömling
Isocyanide-based Multicomponent reactions (IMCR) are by far the most versatile reactions which can construct relatively complex molecules by one-pot synthesis. More importantly, the development of the post IMCR modifications significantly improves the scaffolds diversity. Here, we describe the use of N-Boc protected hydrazine together with -amino acid derived isocyanides in the Ugi tetrazole reaction and its post cyclization under both acidic and basic conditions. The cyclization in acidic condition was conducted in a one pot fashion, which give 7-aminotetrazolopyrazinone (6) and tetrazolotriazepinone (7) cyclic products...
February 9, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28166338/value-in-the-step-2-clinical-skills-examination
#6
Arjun Gupta, Ugis Gruntmanis
No abstract text is available yet for this article.
February 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28161949/one-pot-synthesis-of-indoles-by-sequential-ugi-3cr-wittig-reaction-starting-from-smellless-isocyanide-substituted-phosphonium-salts
#7
Yan-Mei Yan, Yong Rao, Ming-Wu Ding
A new one-pot preparation of indoles by a Ugi-3CR/Wittig sequence has been developed. The reaction of smellless isocyanide substituted phosphonium salt 5, aldehyde 6 and amine 7 produced the indoles 9 in 45-82% yields via sequential Ugi-3CR/Wittig reaction in the presence of H3PO4 and solid K2CO3 respectively.
February 6, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28153488/eliminating-routine-upper-gastrointestinal-contrast-studies-after-sleeve-gastrectomy-decreases-length-of-stay-and-hospitalization-costs
#8
Lionel Rebibo, Cyril Cosse, Brice Robert, Cyril Chivot, Thierry Yzet, Abdennaceur Dhahri, Jean-Marc Regimbeau
BACKGROUND: Recent series have shown the lack of value of routine upper gastrointestinal (UGI) contrast studies on postoperative day 1 or 2 for the detection of gastric leak (GL) after sleeve gastrectomy (SG). Despite this finding, many centers still perform routine early UGI contrast studies after SG. No series has evaluated the impact of eliminating this examination on the overall management of patients undergoing SG. OBJECTIVES: To evaluate the impact of UGI contrast studies on SG management...
October 19, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28147224/effectiveness-of-the-korean-national-cancer-screening-program-in-reducing-gastric-cancer-mortality
#9
Jae Kwan Jun, Kui Son Choi, Hoo-Yeon Lee, Mina Suh, Boyoung Park, Seung Hoon Song, Kyu Won Jung, Chan Wha Lee, Il Ju Choi, Eun-Cheol Park, Dukhyoung Lee
BACKGROUND & AIMS: It is not clear whether screening for gastric cancer by upper endoscopy or upper gastrointestinal (UGI) series examinations (looking at the upper and middle sections of the gastrointestinal tract by imaging techniques) reduces mortality. Nevertheless, the Korean National Cancer Screening Program for gastric cancer was launched in 1999 to screen individuals 40 years and older for gastric cancer using these techniques. We evaluated the effectiveness of these techniques in gastric cancer detection and compared their effects on mortality in the Korean population...
January 29, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28135059/multicomponent-assembly-of-the-kinesin-spindle-protein-ksp-inhibitor-cpuyj039-and-analogs-as-antimitotic-agents
#10
Carlos Carbajales, Junichi Sawada, Giovanni Marzaro, Eddy Sotelo, Luz Escalante, Antonio Sánchez-D Marta, Xerardo García-Mera, Akira Asai, Alberto Coelho
The potent KSP-inhibitor CPUYJ039 and a set of analogs were prepared by a target-oriented approach, based on a Ugi reaction that uses 2-nitrophenyl isocyanides as key building blocks. The herein documented strategy provides a straightforward and atom economical access to potent benzimidazole-based antimitotic agents by exploting the versatility and exploratory power of the Ugi reaction. The results of docking studies and biological activity evaluations of the benzimidazole compounds are also reported.
January 30, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28133657/n-n-bond-formation-in-ugi-processes-from-nitric-acid-to-libraries-of-nitramines
#11
Valentina Mercalli, Aude Nyadanu, Marie Cordier, Gian Cesare Tron, Laurence Grimaud, Laurent El Kaim
The Ugi reaction has drawn considerable attention over the years leading to numerous libraries of heterocycles and various extensions changing the nature of the components of the coupling. We report here the use of nitric acid as carboxylic acids surrogates, displaying the first aminative Ugi-type reaction leading to nitramines.
February 9, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28088773/epidemiology-and-outcome-of-acute-pancreatitis-in-end-stage-renal-disease-dialysis-patients-a-10-year-national-cohort-study
#12
Hung-Jui Chen, Jhi-Joung Wang, Wen-Ing Tsay, Shwu-Huey Her, Cheng-Heng Lin, Chih-Chiang Chien
BACKGROUND: The objective of this study is to determine the incidence and severity of acute pancreatitis (AP) in patients with end-stage renal disease (ESRD) on dialysis and whether the dialysis modality [hemodialysis (HD) versus peritoneal dialysis (PD)] confers a higher risk for AP as well as complications or mortality related to AP. METHODS: We analyzed national health insurance claims data of 67 078 ESRD patients initiating dialysis between 1999 and 2007 in Taiwan...
January 14, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28066847/an-efficient-ugi-3cr-aza-diels-alder-pomeranz-fritsch-protocol-towards-novel-aza-analogues-of-%C3%A2-nuevamine-%C3%A2-lennoxamine-and-magallanesine-a-diversity-oriented-synthesis-approach
#13
Óscar Vázquez-Vera, Jorge S Sánchez-Badillo, Alejandro Islas-Jácome, Manuel A Rentería-Gómez, Shrikant G Pharande, Carlos J Cortes-García, Mónica A Rincón-Guevara, Ilich A Ibarra, Rocío Gámez-Montaño, Eduardo González-Zamora
A rapid and efficient synthesis of a series of (±)-nuevamine, (±)-lennoxamine and magallanesine aza analogues is described. The synthetic strategy involves Ugi-3CR and two further condensation processes, aza-Diels-Alder cycloaddition and the Pomeranz-Fritsch reaction. The variation of the chain-size in aldehyde moieties provided structural diversity in only two operational reaction steps.
January 9, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28050248/management-of-achalasia-in-the-uk-do-we-need-new-guidelines
#14
REVIEW
Jihene El Kafsi, Antonio Foliaki, Thomas C B Dehn, Nicholas D Maynard
AIM: It is recommended that management of complex benign upper gastrointestinal pathology is discussed at multi disciplinary team (MDT) meetings. American College of Gastroenterology (ACG) guidelines further recommend that treatment delivery is provided by high volume centres, with objective post-procedural investigations, in order to improve patient outcomes. We aimed to survey the current UK practice in the management of achalasia. METHODS: 443 Upper gastrointestinal (UGI) specialist surgeons throughout the UK were sent a surveymonkey...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28032204/gastrointestinal-bleeding-due-to-gastrointestinal-tract-malignancy-natural-history-management-and-outcomes
#15
Richard A Schatz, Don C Rockey
BACKGROUND: Gastrointestinal (GI) tumor bleeding can vary from occult bleeding to massive hemorrhage and can be the presenting sign of malignancy. AIMS: Our primary aims were to: (1) characterize the natural history, treatment, and outcomes in patients with GI tumor bleeding and (2) compare and contrast bleeding in upper GI (UGI)/small bowel (SB) and lower GI malignancies. METHODS: Patients with endoscopically confirmed tumor bleeding were identified through search of consecutive electronic medical records: Bleeding was determined by the presence of melena, hematochezia, hematemesis, or fecal occult blood...
February 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28029601/hypothalamic-amp-activated-protein-kinase-regulates-biphasic-insulin-secretion-from-pancreatic-%C3%AE-cells-during-fasting-and-in-type-2-diabetes
#16
Shinji Kume, Motoyuki Kondo, Shiro Maeda, Yoshihiko Nishio, Tsuyoshi Yanagimachi, Yukihiro Fujita, Masakazu Haneda, Keiko Kondo, Akihiro Sekine, Shin-Ich Araki, Hisazumi Araki, Masami Chin-Kanasaki, Satoshi Ugi, Daisuke Koya, Sawako Kitahara, Kiyosumi Maeda, Atsunori Kashiwagi, Takashi Uzu, Hiroshi Maegawa
Glucose-stimulated insulin secretion (GSIS) by pancreatic β cells is biphasic. However, the physiological significance of biphasic GSIS and its relationship to diabetes are not yet fully understood. This study demonstrated that impaired first-phase GSIS follows fasting, leading to increased blood glucose levels and brain glucose distribution in humans. Animal experiments to determine a possible network between the brain and β cells revealed that fasting-dependent hyperactivation of AMP-activated protein kinase in the hypothalamus inhibited first-phase GSIS by stimulating the α-adrenergic pancreatic nerve...
October 28, 2016: EBioMedicine
https://www.readbyqxmd.com/read/28012332/laparoscopic-management-of-severe-reflux-after-sleeve-gastrectomy-using-the-linx-%C3%A2-system-technique-and-one-year-follow-up-case-report
#17
Abdelkader Hawasli, Mark Tarakji, Moayad Tarboush
INTRODUCTION: Management of severe reflux after sleeve gastrectomy (SG) usually requires converting to Roux-en-y gastric bypass (RYGB). We present a case of managing this problem using the LINX(®) system. PRESENTATION OF CASE: In February 2015, we performed a laparoscopic placement of LINX(®) system to treat severe reflux after sleeve gastrectomy on a 25-year-old female. The operative time was 47min. There were no intra or postoperative complications. The hospital stay was one day...
November 29, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28005533/hypothalamic-amp-activated-protein-kinase-regulates-biphasic-insulin-secretion-from-pancreatic-cells-during-fasting-and-in-type-2-diabetes
#18
Shinji Kume, Motoyuki Kondo, Shiro Maeda, Yoshihiko Nishio, Tsuyoshi Yanagimachi, Yukihiro Fujita, Masakazu Haneda, Keiko Kondo, Akihiro Sekine, Shin-Ich Araki, Hisazumi Araki, Masami Chin-Kanasaki, Satoshi Ugi, Daisuke Koya, Sawako Kitahara, Kiyosumi Maeda, Atsunori Kashiwagi, Takashi Uzu, Hiroshi Maegawa
Glucose-stimulated insulin secretion (GSIS) by pancreatic ? cells is biphasic. However, the physiological significance of biphasic GSIS and its relationship to diabetes are not yet fully understood. This study demonstrated that impaired first-phase GSIS follows fasting, leading to increased blood glucose levels and brain glucose distribution in humans. Animal experiments to determine a possible network between the brain and ? cells revealed that fasting-dependent hyperactivation of AMP-activated protein kinase in the hypothalamus inhibited first-phase GSIS by stimulating the ?-adrenergic pancreatic nerve...
November 2016: EBioMedicine
https://www.readbyqxmd.com/read/27994697/acute-reversible-duodenitis-following-non-therapeutic-upper-gastrointestinal-endoscopy-is-duodenal-diverticulum-a-predisposing-factor
#19
Emre Unal, Elif Nurbegum Ayan, Sibel Yazgan
BACKGROUND: Diagnostic upper gastrointestinal (UGI) endoscopy has been regarded as a safe procedure. CASE REPORT: We report of a 67-year-old woman who developed epigastric pain and dyspeptic complaints following an uneventful upper gastrointestinal endoscopy. The diagnosis of an acute reversible duodenitis was made on the basis of imaging studies. A duodenal diverticulum was also found on CT images, which raised the suspicion that duodenal diverticulum could be a predisposing factor for duodenitis...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27935911/giant-left-atrium-a-rare-case-of-acute-upper-gastrointestinal-bleeding
#20
K R Dewan, B S Patowary, S Bhattarai
Acute upper GI bleeding is a common medical emergency with a hospital mortality of approximately 10%. Non variceal UGI bleeding is the most common cause followed by oesophageal varices. Various rare causes have been described in the literature but there are very few cases of giant left atrium leading to oesophageal erosion and causing upper GI bleeding. We are presenting a case of rheumatic valvular heart disease with giant left atrium who presented in our department with acute upper GI bleeding.
January 2016: JNMA; Journal of the Nepal Medical Association
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