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One-pot Ugi-azide and Heck reactions for the synthesis of heterocyclic systems containing tetrazole and 1,2,3,4-tetrahydroisoquinoline.

Jiawei Niu, Yuhui Wang, Shenghu Yan, Yue Zhang, Xiaoming Ma, Qiang Zhang, Wei Zhang
Beilstein Journal of Organic Chemistry 2024
A new method for the synthesis of heterocyclic systems containing tetrazole and tetrahydroisoquinoline is developed via the performance of one-pot Ugi-azide and Heck cyclization reactions. The integration of the multicomponent and post-condensation reactions in one-pot maximizes the pot-, atom-, and step-economy (PASE).

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