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https://www.readbyqxmd.com/read/28226185/p53-protein-accumulation-predicts-malignant-progression-in-barrett-s-metaplasia-a-prospective-study-of-275-patients
#1
Mamoun Younes, Keith Brown, Gregory Y Lauwers, Gulchin Ergun, Frank Meriano, A Carl Schmulen, Alberto Barroso, Atilla Ertan
AIMS: The purpose of this study was to determine prospectively whether p53 protein accumulation in biopsies of Barrett's metaplasia (BM) is a predictor of malignant progression, without relying on dysplasia grading. METHODS AND RESULTS: Sections of formalin fixed paraffin embedded tissue from the initial biopsies of 275 patients with BM, who had no high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC), were stained for p53 by immunohistochemistry. Mean follow up was 41 months...
February 22, 2017: Histopathology
https://www.readbyqxmd.com/read/28225735/evaluating-the-precision-of-auditory-sensory-memory-as-an-index-of-intrusion-in-tinnitus
#2
Doug J K Barrett, Michael Pilling
OBJECTIVES: The purpose of this study was to investigate the potential of measures of auditory short-term memory (ASTM) to provide a clinical measure of intrusion in tinnitus. DESIGN: Response functions for six normal listeners on a delayed pitch discrimination task were contrasted in three conditions designed to manipulate attention in the presence and absence of simulated tinnitus: (1) no-tinnitus, (2) ignore-tinnitus, and (3) attend-tinnitus. RESULTS: Delayed pitch discrimination functions were more variable in the presence of simulated tinnitus when listeners were asked to divide attention between the primary task and the amplitude of the tinnitus tone...
March 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28225709/the-relationship-between-trunk-rotation-upper-quarter-dynamic-stability-and-pitch-velocity
#3
Garrett S Bullock, Abigail C Schmitt, Patrick Chasse, Barrett A Little, Lee H Diehl, Robert J Butler
Understanding the relationship between upper quarter mobility, dynamic stability and pitching velocity may be beneficial in elucidating underlying factors that affect pitching performance. The purpose of this study was to investigate upper trunk rotation mobility and upper quarter dynamic stability and their correlation to pitch velocity in NCAA Division I collegiate pitchers. We hypothesized that collegiate pitchers with greater upper trunk rotation mobility and upper extremity dynamic stability would exhibit higher pitching velocity...
February 21, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28225509/psychometric-properties-of-the-reconstructed-hamilton-depression-and-anxiety-scales
#4
Eliora Porter, Dianne L Chambless, Kevin S McCarthy, Robert J DeRubeis, Brian A Sharpless, Marna S Barrett, Barbara Milrod, Steven D Hollon, Jacques P Barber
Although widely used, the Hamilton Rating Scale for Depression (HRSD) and Hamilton Anxiety Rating Scale (HARS) discriminate poorly between depression and anxiety. To address this problem, Riskind, Beck, Brown, and Steer (J Nerv Ment Dis. 175:474-479, 1987) created the Reconstructed Hamilton Scales by reconfiguring HRSD and HARS items into modified scales. To further analyze the reconstructed scales, we examined their factor structure and criterion-related validity in a sample of patients with major depressive disorder and no comorbid anxiety disorders (n = 215) or with panic disorder and no comorbid mood disorders (n = 149)...
February 20, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28223996/untargeted-metabotyping-lolium-perenne-reveals-population-level-variation-in-plant-flavonoids-and-alkaloids
#5
Mingshu Cao, Karl Fraser, Chris Jones, Alan Stewart, Thomas Lyons, Marty Faville, Brent Barrett
Metabolomics provides a powerful platform to characterize plants at the biochemical level, allowing a search for underlying genes and associations with higher level complex traits such as yield and nutritional value. Efficient and reliable methods to characterize metabolic variation in economically important species are considered of high value to the evaluation and prioritization of germplasm and breeding lines. In this investigation, a large-scale metabolomic survey was performed on a collection of diverse perennial ryegrass (Lolium perenne L...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28223834/bile-salt-receptor-tgr5-is-highly-expressed-in-esophageal-adenocarcinoma-and-precancerous-lesions-with-significantly-worse-overall-survival-and-gender-differences
#6
Chunhong Pang, Amy LaLonde, Tony E Godfrey, Jianwen Que, Jun Sun, Tong Tong Wu, Zhongren Zhou
Bile acid reflux in the esophagus plays an important role in the carcinogenesis of esophageal adenocarcinoma (EAC). The G-protein coupled bile acid receptor (TGR5) has been associated with the development of gastrointestinal cancer. However, little is known regarding the role of TGR5 in esophageal carcinoma and precancerous lesions. We analyzed genomic DNA from 116 EACs for copy number aberrations via Affymetrix SNP6.0 microarrays. The TGR5 gene locus was amplified in 12.7% (14/116) of the EACs. The TGR5 protein expression was also assessed using immunohistochemistry from tissue microarrays, including Barrett's esophagus (BE), low-(LGD) and high-grade dysplasia (HGD), columnar cell metaplasia (CM), squamous epithelium (SE), EAC and squamous cell carcinoma...
2017: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/28223355/glial-fibrillary-acidic-protein-exhibits-altered-turnover-kinetics-in-a-mouse-model-of-alexander-disease
#7
Laura R Moody, Gregory A Barrett-Wilt, Michael R Sussman, Albee Messing
Mutations in the astrocyte-specific intermediate filament, glial fibrillary acidic protein (GFAP), lead to the rare and fatal disorder, Alexander disease (AxD). A prominent feature of the disease is aberrant accumulation of GFAP. It has been proposed that this accumulation occurs due to an increase in gene transcription coupled with impaired proteasomal degradation, yet this hypothesis remains untested. We therefore sought to directly investigate GFAP turnover in a mouse model of AxD that is heterozygous for a disease-causing point mutation (GfapR236H/+) (and thus expresses both wild-type and mutant protein)...
February 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28223289/when-all-you-have-is-a-hammer-the-need-for-tools-to-define-and-apply-patient-centered-outcomes-in-hemodialysis
#8
EDITORIAL
C Barrett Bowling, Laura C Plantinga
No abstract text is available yet for this article.
February 21, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28223274/long-term-responders-on-olaparib-maintenance-in-high-grade-serous-ovarian-cancer-clinical-and-molecular-characterization
#9
Stephanie Lheureux, Zhongwu Lai, Brian A Dougherty, Sarah Runswick, Darren Hodgson, Kirsten M Timms, Jerry S Lanchbury, Stanley B Kaye, Charlie Gourley, David D L Bowtell, Elise C Kohn, Clare L Scott, Ursula A Matulonis, Tony Panzarella, Katherine Karakasis, Julia V Burnier, Blake Gilks, Mark J O'Connor, Jane D Robertson, Jonathan Ledermann, J Carl Barrett, Tony W Ho, Amit M Oza
PURPOSE: Maintenance therapy with olaparib has improved progression-free survival in women with high-grade serous ovarian cancer (HGSOC), particularly those harboring BRCA1/2 mutations. The objective of this study was to characterize long-term (LT) versus short-term (ST) responders to olaparib. EXPERIMENTAL DESIGN: A comparative molecular analysis of Study 19 (NCT00753545), a randomized Phase II trial assessing olaparib maintenance after response to platinum-based chemotherapy in HGSOC, was conducted...
February 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28222825/combined-universal-and-selective-prevention-for-adolescent-alcohol-use-a-cluster-randomized-controlled-trial
#10
M Teesson, N C Newton, T Slade, N Carragher, E L Barrett, K E Champion, E V Kelly, N K Nair, L A Stapinski, P J Conrod
BACKGROUND: No existing models of alcohol prevention concurrently adopt universal and selective approaches. This study aims to evaluate the first combined universal and selective approach to alcohol prevention. METHOD: A total of 26 Australian schools with 2190 students (mean age: 13.3 years) were randomized to receive: universal prevention (Climate Schools); selective prevention (Preventure); combined prevention (Climate Schools and Preventure; CAP); or health education as usual (control)...
February 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28222261/enhanced-release-of-molecules-upon-uv-light-irradiation-from-photoresponsive-hydrogels-prepared-from-bifunctional-azobenzene-and-four-arm-poly-ethylene-glycol
#11
Shiva Kumar Rastogi, Hailee E Anderson, Joseph Lamas, Scott L Barrett, Travis Cantu, Stefan Zauscher, William J Brittain, Tania Betancourt
Advances in biosensors and drug delivery depend on hydrogels that respond to external stimuli. In this work we de-scribe the preparation and characterization of photoresponsive hydrogels prepared by crosslinking of di-NHS ester of azobenzoic acid and four-armed, amine-terminated poly(ethylene glycol). The porous structure and composition of the hydrogels were confirmed by scanning electron microscopy and Fourier transform infrared (FTIR) spectroscopy. The reversible photoisomerization of the azobenzene-containing hydrogel crosslinkers in the gels was confirmed by ab-sorption spectroscopy...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28220892/epigenetic-determinants-of-space-radiation-induced-cognitive-dysfunction
#12
Munjal M Acharya, Al Anoud D Baddour, Takumi Kawashita, Barrett D Allen, Amber R Syage, Thuan H Nguyen, Nicole Yoon, Erich Giedzinski, Liping Yu, Vipan K Parihar, Janet E Baulch
Among the dangers to astronauts engaging in deep space missions such as a Mars expedition is exposure to radiations that put them at risk for severe cognitive dysfunction. These radiation-induced cognitive impairments are accompanied by functional and structural changes including oxidative stress, neuroinflammation, and degradation of neuronal architecture. The molecular mechanisms that dictate CNS function are multifaceted and it is unclear how irradiation induces persistent alterations in the brain. Among those determinants of cognitive function are neuroepigenetic mechanisms that translate radiation responses into altered gene expression and cellular phenotype...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216798/herbivorous-dinosaur-jaw-disparity-and-its-relationship-to-extrinsic-evolutionary-drivers
#13
Jamie A MacLaren, Philip S L Anderson, Paul M Barrett, Emily J Rayfield
Morphological responses of nonmammalian herbivores to external ecological drivers have not been quantified over extended timescales. Herbivorous nonavian dinosaurs are an ideal group to test for such responses, because they dominated terrestrial ecosystems for more than 155 Myr and included the largest herbivores that ever existed. The radiation of dinosaurs was punctuated by several ecologically important events, including extinctions at the Triassic/Jurassic (Tr/J) and Jurassic/Cretaceous (J/K) boundaries, the decline of cycadophytes, and the origin of angiosperms, all of which may have had profound consequences for herbivore communities...
February 2017: Paleobiology
https://www.readbyqxmd.com/read/28216140/expression-profiles-of-cancer-stem-cell-markers-cd133-cd44-musashi-1-and-epcam-in-the-cardiac-mucosa-barrett-s-esophagus-early-esophageal-adenocarcinoma-advanced-esophageal-adenocarcinoma-sequence
#14
Anna Mokrowiecka, Lothar Veits, Christina Falkeis, Jacek Musial, Radzislaw Kordek, Mariusz Lochowski, Jozef Kozak, Agnieszka Wierzchniewska-Lawska, Michael Vieth, Ewa Malecka-Panas
INTRODUCTION: Barrett's esophagus (BE), which develops as a result of gastroesophageal reflux disease, is a preneoplastic condition for esophageal adenocarcinoma (EAC). A new hypothesis suggests that cancer is a disease of stem cells, however, their expression and pathways in BE - EAC sequence are not fully elucidated yet. AIMS: We used a panel of putative cancer stem cells markers to identify stem cells in consecutive steps of BE-related cancer progression. METHODS: Immunohistochemistry was performed on formalin-fixed, paraffin-embedded blocks from 58 patients with normal cardiac mucosa (n=5), BE (n=14), early EAC (pT1) from mucosal resection (n=17) and advanced EAC (pT1-T4) from postoperative specimens (n=22)...
December 30, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28215067/epidemiology-and-natural-history-of-gastro-esophageal-reflux-disease
#15
Edoardo Savarino, Elisa Marabotto, Giorgia Bodini, Gaia Pellegatta, Claudia Coppo, Elisa Giambruno, Matteo Brunacci, Patrizia Zentilin, Vincenzo Savarino
Gastroesophageal reflux disease (GERD) is highly prevalent in Western countries, particularly when considering its most classic symptom, that is heartburn. This symptom is very frequent in the community and ranges from 10% to more than 30%, according to the various population-based studies. This disease is much more represented in Europe and US than in Asiatic countries. It has been shown that GERD prevalence increases in parallel with the remarkable growth of obesity, as this condition is able to favor all the pathogenetic mechanisms leading to it...
February 17, 2017: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/28214947/the-redistribution-of-non-breeding-dunlins-in-response-to-the-post-ddt-recovery-of-falcons
#16
Ronald C Ydenberg, Jennifer Barrett, David B Lank, Cailin Xu, Michiel Faber
Large-scale changes in predator populations are occurring worldwide due to (re-)introductions, over-exploitation, or recovery after decimation by pesticides and persecution. These widespread changes may affect the distribution of their prey. We studied the continental-scale distributions of non-breeding Calidris alpina pacifica and C. a. hudsonia (Pacific and Atlantic dunlins, respectively), as numbers of their major predators-peregrines (Falco peregrinus) and merlins (F. columbarius; together 'falcons')-increased after DDT was banned in 1973...
February 18, 2017: Oecologia
https://www.readbyqxmd.com/read/28214656/risk-of-oesophageal-adenocarcinoma-in-individuals-with-barrett-s-oesophagus
#17
Dag Holmberg, Eivind Ness-Jensen, Fredrik Mattsson, Hashem B El-Serag, Jesper Lagergren
INTRODUCTION: Recent studies have indicated a lower incidence rate of oesophageal adenocarcinoma (OAC) in individuals with Barrett's oesophagus (BO) than most earlier studies. Our objective was to assess the risk of OAC in a Swedish unselected cohort of individuals with BO. METHODS: This population-based cohort study included all Swedish residents diagnosed with BO in 2006-2013, identified through the Swedish Patient Registry. The cohort members were followed from the date of first BO diagnosis until the first occurrence of OAC, high-grade dysplasia (HGD), death, emigration or end of study period...
February 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28213358/fields-of-nursing-do-we-need-them-what-should-they-be-and-when-should-nurses-choose-theirs
#18
David Barrett
No abstract text is available yet for this article.
February 17, 2017: Evidence-based Nursing
https://www.readbyqxmd.com/read/28212604/high-expression-of-claudin-2-in-esophageal-carcinoma-and-precancerous-lesions-is-significantly-associated-with-the-bile-salt-receptors-vdr-and-tgr5
#19
Sohaib Abu-Farsakh, Tongtong Wu, Amy Lalonde, Jun Sun, Zhongren Zhou
BACKGROUND: Claudins are a family of integral membrane proteins and are components of tight junctions (TJs). Many TJ proteins are known to tighten the cell structure and maintain a barrier. Claudin-2 forms gated paracellular channels and allows sodium ions and other small positively charged ions to cross between adjacent cells. Recently, we found that vitamin D receptor (VDR) enhanced Claudin-2 expression in colon and that bile salt receptors VDR and Takeda G-protein coupled receptor5 (TGR5) were highly expressed in esophageal adenocarcinoma (EAC) and precancerous lesions...
February 17, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28212575/upregulation-of-mucin-glycoprotein-muc1-in-the-progression-to-esophageal-adenocarcinoma-and-therapeutic-potential-with-a-targeted-photoactive-antibody-drug-conjugate
#20
Mohammed Adil Butt, Hayley Pye, Rehan J Haidry, Dahmane Oukrif, Saif-U-Rehman Khan, Ignazio Puccio, Michael Gandy, Halla W Reinert, Ellie Bloom, Mohammed Rashid, Gokhan Yahioglu, Mahendra P Deonarain, Rifat Hamoudi, Manuel Rodriguez-Justo, Marco R Novelli, Laurence B Lovat
BACKGROUND: Mucin glycoprotein 1 (MUC1) is a glycosylated transmembrane protein on epithelial cells. We investigate MUC1 as a therapeutic target in Barrett's epithelium (BE) and esophageal adenocarcinoma (EA) and provide proof of concept for a light based therapy targeting MUC1. RESULTS: MUC1 was present in 21% and 30% of significantly enriched pathways comparing BE and EA to squamous epithelium respectively. MUC1 gene expression was x2.3 and x2.2 higher in BE (p=<0...
February 15, 2017: Oncotarget
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