Hedmon Okella, Emmanuel Okello, Andrew Glory Mtewa, Hilda Ikiriza, Bruhan Kaggwa, Jacqueline Aber, Christian Ndekezi, Joseph Nkamwesiga, Clement Olusoji Ajayi, Ivan Mulongo Mugeni, Geofrey Ssentamu, Sylvester Ochwo, Steven Odongo, Casim Umba Tolo, Charles Drago Kato, Patrick Ogwang Engeu
Amidst rising cases of antimicrobial resistance, antimicrobial peptides (AMPs) are regarded as a promising alternative to traditional antibiotics. Even so, poor pharmacokinetic profiles of certain AMPs impede their utility necessitating, a careful assessment of potential AMPs' absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties during novel lead exploration. Accordingly, the present study utilized ADMET scores to profile seven previously isolated African catfish antimicrobial peptides (ACAPs)...
2022: Frontiers in Molecular Biosciences