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https://www.readbyqxmd.com/read/28527386/gait-patterns-of-children-and-adolescents-with-charcot-marie-tooth-disease
#1
Elizabeth Wojciechowski, Amy Sman, Kayla Cornett, Jacqueline Raymond, Kathryn Refshauge, Manoj P Menezes, Joshua Burns
Gait abnormalities reported in childhood Charcot-Marie-Tooth disease (CMT) include foot-drop, reduced ankle power at push-off and increased knee and hip flexion for swing clearance ('steppage-gait'). The purpose of this study was to describe the gait patterns of 60 children aged 6-17 years with CMT (CMTall) and distinguish differences based on functional weakness using the CMT Pediatric Scale (CMTPedS). Data were captured using Vicon Nexus system and compared to 50 healthy norms. Data were subdivided into three groups denoting increasing severity of dorsiflexion and plantarflexion weakness from the CMTPedS: no difficulty heel or toe walking (CMTND), difficulty heel walking (CMTDH), difficulty toe and heel walking (CMTDTH)...
May 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28524066/a-flight-phase-terrain-following-control-strategy-for-stable-and-robust-hopping-of-a-one-legged-robot-under-large-terrain-variations
#2
Natan Shemer, Amir Degani
This work demonstrates a simple, once per step, flight-phase control method for robots running on a planar unknown rough-terrain environment. The robot used to exemplify these control strategies is the ParkourBot, a Spring-Loaded Inverted Pendulum (SLIP)-based robot. The SLIP model is widely used for the description of humans and animals running motion and has been the basis for many robots. A known control scheme for increasing robustness of the conservative, SLIP model is the Swing Leg Retraction (SLR) method...
May 19, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28523258/sexual-self-concept-and-its-relationship-to-depression-stress-and-anxiety-in-postmenopausal-women
#3
Mohammad Heidari, Mansureh Ghodusi, Hossein Rafiei
OBJECTIVES: Women in menopause have the more mood swings than before menopause. At the same time seem to sexual self-concept and sexual aspects of self-knowledge has a great impact on their mental health. This study aimed to investigate the sexual self-concept and its relationship to depression, stress and anxiety in postmenopausal women's. METHODS: In this descriptive correlation research, 300 of postmenopausal women referred to healthcare and medical treatment centers in Abadeh city were selected by convenience sampling method...
April 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28512223/kinematics-of-the-lever-arm-swing-in-myosin-vi
#4
Mauro L Mugnai, D Thirumalai
Myosin VI (MVI) is the only known member of the myosin superfamily that, upon dimerization, walks processively toward the pointed end of the actin filament. The leading head of the dimer directs the trailing head forward with a power stroke, a conformational change of the motor domain exaggerated by the lever arm. Using a unique coarse-grained model for the power stroke of a single MVI, we provide the molecular basis for its motility. We show that the power stroke occurs in two major steps. First, the motor domain attains the poststroke conformation without directing the lever arm forward; and second, the lever arm reaches the poststroke orientation by undergoing a rotational diffusion...
May 16, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28509763/achilles-tendon-load-is-progressively-increased-with-reductions-in-walking-speed
#5
Torsten Brauner, Philippe Pourcelot, Nathalie Crevier-Denoix, Thomas Horstmann, Scott C Wearing
INTRODUCTION: Achilles tendon rehabilitation protocols commonly recommend a gradual increase in walking speed to progressively intensify tendon loading. This study used transmission-mode ultrasound to evaluate the influence of walking speed on loading of the human Achilles tendon in vivo. METHODS: Axial transmission speed of ultrasound was measured in the right Achilles tendon of 33 adults (mean ± SD; age, 29 ± 3 years; height, 1.725 ± 0.069 m; weight, 71.4 ± 19...
May 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28505991/lower-extremity-robotic-exoskeleton-training-case-studies-for-complete-spinal-cord-injury-walking
#6
Edward D Lemaire, Andrew J Smith, Andrew Herbert-Copley, Vidya Sreenivasan
BACKGROUND: Recent advances in exoskeleton technology has made lower extremity powered exoskeletons (LEPE) a viable treatment tool to restore upright walking mobility to persons with spinal cord injury (SCI). OBJECTIVE: Evaluate ARKE exoskeleton training within a rehabilitation centre environment. METHODS: Case studies are presented for two male participants, age 41 and 30, motor complete SCI at T6 (N01) and T12 (N02), respectively, as they progress from new LEPE users to independent walking...
May 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28503144/rigid-ankle-foot-orthosis-deteriorates-mediolateral-balance-control-and-vertical-braking-during-gait-initiation
#7
Arnaud Delafontaine, Olivier Gagey, Silvia Colnaghi, Manh-Cuong Do, Jean-Louis Honeine
Rigid ankle-foot orthoses (AFO) are commonly used for impeding foot drop during the swing phase of gait. They also reduce pain and improve gait kinematics in patients with weakness or loss of integrity of ankle-foot complex structures due to various pathological conditions. However, this comes at the price of constraining ankle joint mobility, which might affect propulsive force generation and balance control. The present study examined the effects of wearing an AFO on biomechanical variables and electromyographic activity of tibialis anterior (TA) and soleus muscles during gait initiation (GI)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28501788/dynamic-femoral-head-translations-in-dysplastic-hips
#8
Tatsuya Sato, Hiromasa Tanino, Yasuhiro Nishida, Hiroshi Ito, Takeo Matsuno, Scott A Banks
BACKGROUND: Developmental dysplasia of the hip is an important disease leading to osteoarthritis. Recently, researchers have focused on hip instability as a potentially important dynamic factor for osteoarthritis, but the detailed kinematics of dysplastic hips during weight-bearing gait have not been reported. The purpose of this research is to contrast femoral translation in contralateral healthy hips and dysplastic hips during weight-bearing stepping. METHODS: Twelve dysplastic hips and eight healthy hips were investigated...
May 5, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28501732/asymmetrical-stabilization-and-mobilization-exploited-during-static-single-leg-stance-and-goal-directed-kicking
#9
Adam C King, Zheng Wang
The motor control properties of the right and left legs are dependent on the stabilization and mobilization features of the motor tasks. The current investigation examined the right and left leg control differences - interlateral asymmetries - during static single leg stance and dynamic goal directed kicking with an emphasis of the asymmetrical stabilization and mobilization components of movements. Ten young, healthy, right-leg preferred individuals with minimal kicking experience completed both tests on each limb...
May 11, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28499196/binding-induced-dna-walker-for-signal-amplification-in-highly-selective-electrochemical-detection-of-protein
#10
Yuhang Ji, Lei Zhang, Longyi Zhu, Jianping Lei, Jie Wu, Huangxian Ju
A binding-induced DNA walker-assisted signal amplification was developed for highly selective electrochemical detection of protein. Firstly, the track of DNA walker was constructed by self-assembly of the high density ferrocene (Fc)-labeled anchor DNA and aptamer 1 on the gold electrode surface. Sequentially, a long swing-arm chain containing aptamer 2 and walking strand DNA was introduced onto gold electrode through aptamers-target specific recognition, and thus initiated walker strand sequences to hybridize with anchor DNA...
May 4, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28499087/identification-of-intra-helical-bifurcated-h-bonds-as-a-new-type-of-gate-in-k-channels
#11
Oliver Rauh, Martin Urban, Leonhard M Henkes, Tobias Winterstein, Timo Greiner, James L Van Etten, Anna Moroni, Stefan M M Kast, Gerhard Thiel, Indra Schroeder
Gating of ion channels is based on structural transitions between open and closed states. To uncover the chemical basis of individual gates, we performed a comparative experimental and computational analysis between two K+ channels, KcvS and KcvNTS. These small viral encoded K+ channel proteins, with a monomer size of only 82 amino acids, resemble the pore module of all complex K+ channels in terms of structure and function. Even though both proteins share about 90% amino acid sequence identi-ty they exhibit different open probabilities with ca...
May 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28496403/hysteresis-in-center-of-mass-velocity-control-during-the-stance-phase-of-treadmill-walking
#12
Kyoung-Hyun Lee, Raymond K Chong
Achieving a soft landing during walking can be quantified by analyzing changes in the vertical velocity of the body center of mass (CoM) just prior to the landing of the swing limb. Previous research suggests that walking speed and step length may predictably influence the extent of this CoM control. Here we ask how stable this control is. We altered treadmill walking speed by systematically increasing or decreasing it at fixed intervals. We then reversed direction. We hypothesized that the control of the CoM vertical velocity during the late stance of the walking gait may serve as an order parameter which has an attribute of hysteresis...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28495224/a-solid-swing-and-%C3%A2-contact-or-miss-commentary-on-towards-a-grand-unified-theory-of-sports-performance
#13
Stephen Cobley, Ross Sanders, Mark Halaki, Nicholas O'Dwyer
No abstract text is available yet for this article.
May 8, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28494322/constituent-lower-extremity-work-clew-approach-a-novel-tool-to-visualize-joint-and-segment-work
#14
Anahid Ebrahimi, Saryn R Goldberg, Jason M Wilken, Steven J Stanhope
Work can reveal the mechanism by which movements occur. However, work is less physically intuitive than more common clinical variables such as joint angles, and are scalar quantities which do not have a direction. Therefore, there is a need for a clearly reported and comprehensively calculated approach to easily visualize and facilitate the interpretation of work variables in a clinical setting. We propose the Constituent Lower Extremity Work (CLEW) approach, a general methodology to visualize and interpret cyclic tasks performed by the lower limbs...
April 24, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28493868/vertical-ground-reaction-force-marker-for-parkinson-s-disease
#15
Md Nafiul Alam, Amanmeet Garg, Tamanna Tabassum Khan Munia, Reza Fazel-Rezai, Kouhyar Tavakolian
Parkinson's disease (PD) patients regularly exhibit abnormal gait patterns. Automated differentiation of abnormal gait from normal gait can serve as a potential tool for early diagnosis as well as monitoring the effect of PD treatment. The aim of current study is to differentiate PD patients from healthy controls, on the basis of features derived from plantar vertical ground reaction force (VGRF) data during walking at normal pace. The current work presents a comprehensive study highlighting the efficacy of different machine learning classifiers towards devising an accurate prediction system...
2017: PloS One
https://www.readbyqxmd.com/read/28492919/striving-for-clarity-about-the-best-approach-to-thyroid-cancer-screening-and-treatment-is-the-pendulum-swinging-too-far
#16
Julie Ann Sosa, Quan-Yang Duh, Gerard Doherty
No abstract text is available yet for this article.
May 9, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28490642/split-arm-swinging-the-effect-of-arm-swinging-manipulation-on-inter-limb-coordination-during-walking
#17
Moshe Bondi, Gabi Zeilig, Ayala Bloch, Alfonso Fasano, Meir Plotnik
Human locomotion is defined by bilateral coordination of gait (BCG) and shared features with the fore-hind limb coordination of quadrupeds. The objective of the present study is to explore the influence of arm swinging (AS) on BCG. Sixteen young healthy individuals (eight females; eight right motor-dominant, eight left-motor dominant) participated. Participants performed 10 walking trials (2 min). In each of the trials AS was unilaterally manipulated (e.g., arm restriction, weight on the wrist) bilaterally manipulated, or not manipulated...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28490249/novel-single-marker-approach-to-estimation-of-lower-extremity-movement
#18
Fateme Navvab Motlagh, Ahmad Reza Arshi
Sacrum motion is used extensively in studying the biomechanical characteristics of walking. This study aimed at investigating the potential of sacrum motion to provide an estimation of important gait events in conjunction with predicting the motion of lower extremity segments. Three-dimensional trajectories of 37 reflective markers placed on anatomical landmarks of 14 healthy subjects were recorded while walking at self-selected normal walking speed on treadmill. Elevation angles of lower extremity segments in sagittal plane were estimated using the lower extremity markers...
May 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28490211/aav-vectors-and-stem-cells-friends-or-foes
#19
Nolan Brown, Liujiang Song, Nageswara Rao Kollu, Matt Hirsch
The infusion of healthy stem cells into a patient, termed stem cell therapy, has shown great promise for the treatment of genetic and non-genetic diseases including mucopolysaccharidosis type 1, Parkinson's disease, multiple sclerosis, numerous immunodeficiency disorders, and aplastic anemia. Stem cells for cell therapy can be collected from the patient (autologous) or collected from another "healthy" individual (allogeneic). The use of allogenic stem cells is accompanied with the potentially fatal risk that the transplanted donor T cells will reject the patient's cells, a process termed graft-versus-host disease...
May 10, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28489103/triethanolamine-doped-multilayer-mos2-field-effect-transistors
#20
Min-Yeul Ryu, Ho-Kyun Jang, Kook Jin Lee, Mingxing Piao, Seung-Pil Ko, Minju Shin, Junghwan Huh, Gyu-Tae Kim
Chemical doping has been investigated as an alternative method of conventional ion implantation for two-dimensional materials. We herein report chemically doped multilayer molybdenum disulfide (MoS2) field effect transistors (FETs) through n-type channel doping, wherein triethanolamine (TEOA) is used as an n-type dopant. As a result of the TEOA doping process, the electrical performances of multilayer MoS2 FETs were enhanced at room temperature. Extracted field effect mobility was estimated to be ∼30 cm(2) V(-1) s(-1) after the surface doping process, which is 10 times higher than that of the pristine device...
May 10, 2017: Physical Chemistry Chemical Physics: PCCP
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