Dimitris Anastasios Palamidas, Ourania D Argyropoulou, Natalia Georgantzoglou, Elli Karatza, Evangelia Xingi, Efstathia K Kapsogeorgou, Constantinos D Anagnostopoulos, Andreas C Lazaris, Konstantinos Ritis, Andreas V Goules, Konstantinos Kambas, Athanasios G Tzioufas
OBJECTIVES: To explore the presence of neutrophil extracellular traps (NETs) in inflamed temporal artery biopsies (TABs) of patients with giant cell arteritis (GCA). METHODS: Ten patients with GCA [5 with limited and 5 with associated generalized vascular involvement, as defined by 18F-fluorodeoxyglucose (FDG) positron-emission tomography with computed tomography (PET/CT)] and 8 with polymyalgia rheumatica (PMR) were studied. The presence, location, quantitation, and decoration of NETs with IL-6, IL-1β, and IL-17A were assessed in TABs at the time of disease diagnosis by tissue immunofluorescence and confocal microscopy...
July 14, 2021: Rheumatology