Di Lang, Haibo Ni, Roman Y Medvedev, Fang Liu, Claudia P Alvarez-Baron, Leonid Tyan, Daniel G P Turner, Aleah Warden, Stefano Morotti, Thomas A Schrauth, Christian Rickert, Catherine Proenza, Baron Chanda, Timothy J Kamp, Gail A Robertson, Eleonora Grandi, Alexey V Glukhov
BACKGROUND: Heart rhythm relies on complex interactions between the electrogenic membrane proteins and intracellular Ca 2+ signaling in sinoatrial node (SAN) myocytes; however, the mechanisms underlying the functional organization of the proteins involved in SAN pacemaking and its structural foundation remain elusive. Caveolae are nanoscale, plasma membrane pits that compartmentalize various ion channels and transporters, including those involved in SAN pacemaking, via binding with the caveolin-3 scaffolding protein, however the precise role of caveolae in cardiac pacemaker function is unknown...
April 17, 2024: bioRxiv