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https://www.readbyqxmd.com/read/28073797/physical-and-cultural-determinants-of-postpartum-pelvic-floor-support-and-symptoms-following-vaginal-delivery-a-protocol-for-a-mixed-methods-prospective-cohort-study
#1
Ingrid E Nygaard, Erin Clark, Lauren Clark, Marlene J Egger, Robert Hitchcock, Yvonne Hsu, Peggy Norton, Ana Sanchez-Birkhead, Janet Shaw, Xiaoming Sheng, Michael Varner
INTRODUCTION: Pelvic floor disorders (PFDs), including pelvic organ prolapse (POP), stress and urgency urinary incontinence, and faecal incontinence, are common and arise from loss of pelvic support. Although severe disease often does not occur until women become older, pregnancy and childbirth are major risk factors for PFDs, especially POP. We understand little about modifiable factors that impact pelvic floor function recovery after vaginal birth. This National Institutes of Health (NIH)-funded Program Project, 'Bridging physical and cultural determinants of postpartum pelvic floor support and symptoms following vaginal delivery', uses mixed-methods research to study the influences of intra-abdominal pressure, physical activity, body habitus and muscle fitness on pelvic floor support and symptoms as well as the cultural context in which women experience those changes...
January 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28050782/colorectal-cancer-in-inflammatory-bowel-diseases-a-population-based-study-in-utah
#2
N Jewel Samadder, John F Valentine, Stephen Guthery, Harminder Singh, Charles N Bernstein, Yuan Wan, Jathine Wong, Kenneth Boucher, Lisa Pappas, Kerry Rowe, Mary Bronner, Cornelia M Ulrich, Randall W Burt, Karen Curtin, Ken R Smith
BACKGROUND AND AIMS: The molecular, endoscopic, and histological features of IBD-associated CRC differ from sporadic CRC. The objective of this study was to describe the prevalence, clinical features, and prognosis of IBD-associated CRC compared to patients with sporadic CRC in a US statewide population-based cohort. METHODS: All newly diagnosed cases of CRC between 1996 and 2011 were obtained from Utah Cancer Registry. IBD was identified using a previously validated algorithm, from statewide databases of Intermountain Healthcare, University of Utah Health Sciences, and the Utah Population Database...
January 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28018760/early-results-of-pilot-study-using-hepatitis-c-virus-hcv-positive-kidneys-to-transplant-hcv-infected-patients-with-end-stage-renal-disease-allowing-for-successful-interferon-free-direct-acting-antiviral-therapy-after-transplantation
#3
Juan F Gallegos-Orozco, Robin Kim, Heather F Thiesset, Jenny Hatch, Keisa Lynch, Thomas Chaly, Fuad Shihab, Faris Ahmed, Isaac Hall, Jeffrey Campsen
INTRODUCTION: Hepatitis C virus (HCV) infection in kidney transplant (KTX) patients reduces long-term patient and graft survival. Direct-acting antivirals (DAA) are > 90% effective in achieving sustained viral response (SVR); however, DAAs are not routinely available to patients with end-stage renal disease (ESRD). The University of Utah Transplant Program developed a protocol to allow HCV-positive potential KTX recipients to accept HCV-positive donors' kidneys. Three months after successful KTX, they were eligible for DAA therapy...
November 22, 2016: Curēus
https://www.readbyqxmd.com/read/28006979/dyslipidemia-screening-of-9-to-11-year-olds-at-well-child-visits-by-utah-pediatricians
#4
Carole Stipelman, Paul C Young, Joni Hemond, Laura L Brown, Nicole L Mihalopoulos
In 2011, an expert National Institutes of Health panel published the "Integrated Guidelines for CV Health and Risk Reduction in Children and Adolescents," which recommended screening all children aged 9 to 11 years for dyslipidemia. It is unknown if this guideline is being followed. We surveyed members of the Utah chapter of the American Academy of Pediatrics to determine whether they performed universal lipid screening at well-child visits (WCV) on their patients at 9,10, or 11 years and how comfortable they were with evaluating and/or managing children with dyslipidemia...
December 1, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27960602/use-of-immunosuppressive-medications-for-treatment-of-pediatric-intermediate-uveitis
#5
Aimee O Hersh, Spencer Cope, John F Bohnsack, Akbar Shakoor, Albert T Vitale
PURPOSE: To describe the treatment and outcomes of a cohort of pediatric intermediate uveitis (IU) patients, with a particular focus on the use of immunomodulatory therapy (IMT). METHODS: The disease course, treatment, and outcomes of 39 pediatric IU patients treated in the Uveitis Clinic at the University of Utah from 1999 to 2012 were reviewed, retrospectively. RESULTS: Mean age at presentation was 7.7 years (SD 3.1). In total, 95% had bilateral involvement...
December 14, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27927843/risk-of-childhood-mortality-in-family-members-of-men-with-poor-semen-quality
#6
Heidi A Hanson, Erik N Mayer, Ross E Anderson, Kenneth I Aston, Douglas T Carrell, Justin Berger, William T Lowrance, Ken R Smith, James M Hotaling
STUDY QUESTION: What is the familial childhood mortality in first-degree (FDR) and second-degree relatives (SDR) of patients undergoing semen analysis (SA)? SUMMARY ANSWER: The relationship between infertility and congenital malformations (CM) in offspring is complex, with an increased risk of death due to CM in FDR, but not SDR, of men with lower semen parameters. WHAT IS KNOWN ALREADY: Semen quality is an established predictor of men's somatic health...
January 2017: Human Reproduction
https://www.readbyqxmd.com/read/27891635/potential-association-between-drug-shortages-and-high-cost-medications
#7
Erin R Fox, Linda S Tyler
Shortages and sudden price increases of certain drugs may both occur emergently, with little to no warning, and they can have a dramatic impact on patient care. Little data are available linking drug shortages and price increases. Many of the same characteristics that may make medications susceptible to shortages can also place them at risk for sudden price increases. These characteristics include unapproved drugs, off-patent sole-source medications, and infrequently used medications. We reviewed drug shortage data from the University of Utah Drug Information Service to demonstrate how frequently these characteristics occurred and resulted in higher drug prices...
January 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/27795338/clinical-microbiology-laboratories-adoption-of-culture-independent-diagnostic-tests-is-a-threat-to-foodborne-disease-surveillance-in-the-united-states
#8
Shari Shea, Kristy A Kubota, Hugh Maguire, Stephen Gladbach, Amy Woron, Robyn Atkinson-Dunn, Marc Roger Couturier, Melissa B Miller
INTRODUCTIONIn November 2015, the Centers for Disease Control and Prevention (CDC) sent a letter to state and territorial epidemiologists, state and territorial public health laboratory directors, and state and territorial health officials. In this letter, culture-independent diagnostic tests (CIDTs) for detection of enteric pathogens were characterized as "a serious and current threat to public health surveillance, particularly for Shiga toxin-producing Escherichia coli (STEC) and Salmonella" The document says CDC and its public health partners are approaching this issue, in part, by "reviewing regulatory authority in public health agencies to require culture isolates or specimen submission if CIDTs are used...
January 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27757040/same-day-physical-therapy-consults-in-an-outpatient-neuromuscular-disease-physician-clinic
#9
Evan M Pucillo, Nancy Christensen-Mayer, Shelly D Poole, Denise M Whitten, Danielle Freeman, Blake R Bohe, Brandon R Swensen, A Gordon Smith, Nicholas E Johnson
BACKGROUND: Team-based care has been shown to offer more comprehensive benefits to patients when compared to standard physician-based care alone in clinics for chronic conditions. However, apart from grant-funded multidisciplinary clinics, there are no reports on the usage of same-day physical therapy (PT) consults within a daily outpatient neuromuscular disease (NMD) physician clinic. OBJECTIVE: To determine the impact of same-day PT consults at the University of Utah's outpatient Clinical Neurosciences Center...
2016: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/27729941/conditional-survival-of-metastatic-renal-cell-carcinoma-patients-treated-with-high-dose-interleukin-2
#10
David M Gill, David D Stenehjem, Kinjal Parikh, Joseph Merriman, Arun Sendilnathan, Archana M Agarwal, Andrew W Hahn, Sumati Gupta, Srinivas Kiran Tantravahi, Wolfram E Samlowski, Neeraj Agarwal
Conditional survival (CS) is a clinically useful prediction measure which adjusts a patient's prognosis based on their duration of survival since initiation of therapy. CS has been described in numerous malignancies, and recently described in patients with metastatic renal cell carcinoma (mRCC) who received vascular endothelial growth factor tyrosine kinase inhibitor (VEGFTKI) therapy. However, CS has been not reported in the context of mRCC treated with high-dose interleukin-2 therapy (HDIL-2). A total of 176 patients with histologically confirmed metastatic clear cell RCC (mccRCC) treated with HDIL-2 at the University of Utah Huntsman Cancer Institute from 1988-2012 were evaluated...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27723541/prevalence-and-correlates-of-bipolar-spectrum-disorder-comorbid-with-adhd-features-in-nonclinical-young-adults
#11
Hee Ryung Wang, Young-Eun Jung, Sang-Keun Chung, Jeongwan Hong, Na Ri Kang, Moon-Doo Kim, Won-Myong Bahk
BACKGROUND: We investigate the rate of bipolar spectrum disorder comorbid with ADHD features using two screening instruments, the Mood Disorder Questionnaire (MDQ) and the Wender Utah Rating Scale (WURS), in a nonclinical young adult population. METHODS: College and graduate students aged 18 years or older from four universities in Korea were selected. Comorbidity was defined as both MDQ positivity and WURS positivity. To look for a trend in clinical characteristics according to the severity of the comorbid condition, we used the Jonckheere-Terpstra test and the linear-by-linear association test...
September 28, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27697254/comparison-of-different-types-of-phacoemulsification-tips-i-quantitative-analysis-of-elemental-composition-and-tip-surface-microroughness
#12
Konstantinos T Tsaousis, Liliana Werner, Jesus Paulo Perez, He J Li, Nicholas Reiter, Jia J Guan, Nick Mamalis
PURPOSE: To evaluate the elemental composition of phacoemulsification tips and their surface roughness in the microscale. SETTING: John A. Moran Eye Center and Utah Nanofab, College of Engineering, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Seven types of phacoemulsification tips were studied. The phaco tips were examined through energy-dispersive x-ray spectroscopy (EDS) and x-ray photoelectron spectroscopy (XPS) for elemental composition...
September 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27697251/late-postoperative-opacification-of-a%C3%A2-hydrophilic-hydrophobic-acrylic-intraocular-lens
#13
Paula Bompastor-Ramos, João Póvoa, Conceição Lobo, Alejandra E Rodriguez, Jorge L Alió, Liliana Werner, Joaquim N Murta
PURPOSE: To report late postoperative opacification of a model of hydrophilic-hydrophobic acrylic intraocular lens (IOL) as well as the clinical consequences and laboratory characteristics. SETTING: Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. DESIGN: Retrospective case series. METHODS: Medical records were reviewed of patients with Lentis LS-502-1 IOL opacification reporting visual loss who had IOL explantation between November 2013 and March 2015...
September 2016: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/27681531/hyperfocusing-as-a-dimension-of-adult-attention-deficit-hyperactivity-disorder
#14
Erguvan Tugba Ozel-Kizil, Ahmet Kokurcan, Umut Mert Aksoy, Bilgen Bicer Kanat, Direnc Sakarya, Gulbahar Bastug, Burcin Colak, Umut Altunoz, Sevinc Kirici, Hatice Demirbas, Bedriye Oncu
Patients with Attention Deficit Hyperactivity Disorder (ADHD) suffer not only from inability to focus but also from inability to shift attention for events that trigger their interests. This phenomenon is called "hyperfocusing". Previous literature about hyperfocusing is scarce and relies mainly on case reports. The study aimed to investigate and compare the severity of hyperfocusing in adult ADHD with and without psycho-stimulant use. ADHD (DSM-IV-TR) patients either psycho-stimulant naive (n=53) or on psycho-stimulants (n=79) from two ADHD clinics were recruited...
December 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27681089/a-novel-qtl-associated-with-dwarf-bunt-resistance-in-idaho-444-winter-wheat
#15
Jianli Chen, Mary J Guttieri, Junli Zhang, David Hole, Edward Souza, Blair Goates
A novel QTL, Q.DB.ui-7DS, and the PCR-based markers identified in the current study will accelerate variety development for resistance to dwarf and common bunt of wheat. Dwarf bunt [Tilletia controversa J.G. Kühn [as 'contraversa'], in Rabenhorst, Hedwigia 13: 188 (1874)] is a destructive disease of wheat (Triticum aestivum L.) that reduces grain yield and quality. A number of distinct genes conferring resistance to dwarf bunt have been used by breeding programs for nearly 100 years. However, few markers were identified that can be used in selection of dwarf bunt resistance...
December 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27623461/implementation-of-a-value-driven-outcomes-program-to-identify-high-variability-in-clinical-costs-and-outcomes-and-association-with-reduced-cost-and-improved-quality
#16
Vivian S Lee, Kensaku Kawamoto, Rachel Hess, Charlton Park, Jeffrey Young, Cheri Hunter, Steven Johnson, Sandi Gulbransen, Christopher E Pelt, Devin J Horton, Kencee K Graves, Tom H Greene, Yoshimi Anzai, Robert C Pendleton
IMPORTANCE: Transformation of US health care from volume to value requires meaningful quantification of costs and outcomes at the level of individual patients. OBJECTIVE: To measure the association of a value-driven outcomes tool that allocates costs of care and quality measures to individual patient encounters with cost reduction and health outcome optimization. DESIGN, SETTING, AND PARTICIPANTS: Uncontrolled, pre-post, longitudinal, observational study measuring quality and outcomes relative to cost from 2012 to 2016 at University of Utah Health Care...
September 13, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27621024/industry-academic-partnerships-an-approach-to-accelerate-innovation
#17
Jennwood Chen, Timothy Pickett, Ashley Langell, Ashley Trane, Brian Charlesworth, Kris Loken, Sarah Lombardo, John T Langell
BACKGROUND: Biotechnology companies are process-driven organizations and often struggle with their ability to innovate. Universities, on the other hand, thrive on discovery and variation as a source of innovation. As such, properly structured academic-industry partnerships in medical technology development may enhance and accelerate innovation. Through joint industry-academic efforts, our objective was to develop a technology aimed at global cervical cancer prevention. METHODS: Our Center for Medical Innovation assembled a multidisciplinary team of students, surgical residents, and clinical faculty to enter in the University of Utah's annual Bench-to-Bedside competition...
September 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27618586/a-validated-open-source-multi-solver-fourth-generation-composite-femur-model
#18
Alisdair R MacLeod, Hannah Rose, Harinderjit S Gill
For the first time, an experimentally validated finite element model of a composite femur is presented for use in the three solvers: ABAQUS (Simulia); ANSYS (ANSYS, Inc.) and FEBio (University of Utah). This model is freely available online [web address tbc] along with all supporting validation data. Synthetic biomechanical test specimens are frequently used for pre-clinical evaluation of implant performance, often in combination with numerical modelling such as Finite Element (FE) analysis. The primary aim of the study to conduct a comparison of mesh convergence and strain prediction between three solvers (ABAQUS, ANSYS and FEBio) and to provide validated open-source models of a fourth generation composite femur for use all three FE packages...
September 12, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27611201/adjuvant-radiotherapy-for-atypical-meningiomas
#19
Hilary P Bagshaw, Lindsay M Burt, Randy L Jensen, Gita Suneja, Cheryl A Palmer, William T Couldwell, Dennis C Shrieve
OBJECTIVE The aim of this paper was to evaluate outcomes in patients with atypical meningiomas (AMs) treated with surgery alone compared with surgery and radiotherapy at initial diagnosis, or at the time of first recurrence. METHODS Patients with pathologically confirmed AMs treated at the University of Utah from 1991 to 2014 were retrospectively reviewed. Local control (LC), overall survival (OS), Karnofsky Performance Status (KPS), and toxicity were assessed. Outcomes for patients receiving adjuvant radiotherapy were compared with those for patients treated with surgery alone...
September 9, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27559830/update-interim-guidance-for-the-evaluation-and-management-of-infants-with-possible-congenital-zika-virus-infection-united-states-august-2016
#20
Kate Russell, Sara E Oliver, Lillianne Lewis, Wanda D Barfield, Janet Cragan, Dana Meaney-Delman, J Erin Staples, Marc Fischer, Georgina Peacock, Titilope Oduyebo, Emily E Petersen, Sherif Zaki, Cynthia A Moore, Sonja A Rasmussen
CDC has updated its interim guidance for U.S. health care providers caring for infants born to mothers with possible Zika virus infection during pregnancy (1). Laboratory testing is recommended for 1) infants born to mothers with laboratory evidence of Zika virus infection during pregnancy and 2) infants who have abnormal clinical or neuroimaging findings suggestive of congenital Zika syndrome and a maternal epidemiologic link suggesting possible transmission, regardless of maternal Zika virus test results...
August 26, 2016: MMWR. Morbidity and Mortality Weekly Report
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