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https://www.readbyqxmd.com/read/29346577/improved-success-rate-of-arterial-puncture-for-blood-gas-analysis-through-standardization
#1
Phillip R Jensen, Boaz A Markewitz
Background: Arterial puncture for blood gas analysis is a common procedure in hospitals. The aim of the study is to determine if standardizing technique elements of the arterial puncture process could improve the success rate of technicians through the full scope of an academic medical center. Methods: The study is conducted by the Blood Gas Laboratory at University of Utah Health's main campus. During the baseline period, technicians tallied whether arterial puncture attempts were successful or unsuccessful from December 2014 through February 2015...
January 13, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29344058/an-estimation-of-the-risk-of-pseudotumor-cerebri-among-users-of-the-levonorgestrel-intrauterine-device
#2
Reuben M Valenzuela, Ruju Rai, Brian H Kirk, Jessica N Sanders, Subhashree Sundar, Steffen Hamann, Judith E A Warner, Kathleen B Digre, Alison V Crum, Kirtly P Jones, Bradley J Katz
Because of a previous association of pseudotumor cerebri (PTC) with levonorgestrel, we wished to evaluate the use of levonorgestrel-eluting intrauterine devices ("levonorgestrel intrauterine systems", LNG-IUS) in our University of Utah and Rigshospitalet PTC patients. In our retrospective series, PTC prevalence was approximately 0.18% and 0.15% in the LNG-IUS population versus 0.02% and 0.04% in the non-LNG-IUS population (Utah and Rigshospitalet, respectively), with no significant differences in PTC signs and symptoms among the two groups...
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29335105/optimization-and-comparison-of-a-0-7%C3%A2-mm-tip-with-the-0-9%C3%A2-mm-tip-on-an-active-fluidics-phacoemulsification-platform
#3
Tyler Boulter, Michael D Christensen, Jason D Jensen, Mark Robinson, Brian Zaugg, Brian C Stagg, Jeff H Pettey, Ashlie Bernhisel, William R Barlow, Randall J Olson
PURPOSE: To assess the effect of varying levels of torsional power on phacoemulsification efficiency using an active-fluidics phacoemulsification platform with a 0.7 mm Sonata tip. SETTING: John A. Moran Eye Center Laboratories, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: A 0.7 mm tip was used to emulsify 2.0 mm porcine lenses that had been hardened in formalin. The torsional power was varied from 10% to 100% at intervals of 10%, and efficiency and chatter were recorded...
December 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29334519/the-most-common-causes-of-eye-pain-at-2-tertiary-ophthalmology-and-neurology-clinics
#4
Randy C Bowen, Jan N Koeppel, Chance D Christensen, Karisa B Snow, Junjie Ma, Bradley J Katz, Howard R Krauss, Klara Landau, Judith E A Warner, Alison V Crum, Dominik Straumann, Kathleen B Digre
BACKGROUND: Eye pain is a common complaint, but no previous studies have determined the most common causes of this presenting symptom. Our objective was to determine the most common causes of eye pain in 2 ophthalmology and neurology departments at academic medical centers. METHODS: This was a retrospective cross-sectional analysis and chart review at the departments of ophthalmology and neurology at the University Hospital Zurich (USZ), University of Zürich, Switzerland, and the University of Utah (UU), USA...
January 12, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29283085/outcomes-of-revision-surgery-for-difficult-to-catheterize-continent-channels-in-a-multi-institutional-cohort-of-adults
#5
Ronak Ambrish Gor
INTRODUCTION: We aimed to describe the strategies of surgical revision for catheterizable channel obstruction and their outcomes, including restenosis and new channel incontinence. METHODS: We retrospectively queried the charts of adults who underwent catheterizable channel revision or replacement from 2000-2014 for stomal stenosis, channel obstruction, or difficulty with catheterization at the Universities of Minnesota, Michigan, and Utah. The primary endpoint was channel patency as measured by freedom from repeat surgical intervention...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29223237/effect-of-chamber-stabilization-software-on-efficiency-and-chatter-in-a-porcine-lens-model
#6
Alex J Wright, Rhett S Thomson, Ashlie A Bernhisel, Brian Zaugg, William R Barlow, Jeff H Pettey, Randall J Olson
PURPOSE: To evaluate the effects of the use of programmable chamber stabilization software (Chamber Stabilization Environment) settings on efficiency and chatter in a porcine lens model. SETTING: John A. Moran Eye Center Laboratory, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Porcine eyes were dissected and the lenses extracted. The lenses were then hardened and processed for the experiment...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29218922/methods-for-examining-data-quality-in-healthcare-integrated-data-repositories
#7
Vojtech Huser, Michael G Kahn, Jeffrey S Brown, Ramkiran Gouripeddi
This paper summarizes content of the workshop focused on data quality. The first speaker (VH) described data quality infrastructure and data quality evaluation methods currently in place within the Observational Data Science and Informatics (OHDSI) consortium. The speaker described in detail a data quality tool called Achilles Heel and latest development for extending this tool. Interim results of an ongoing Data Quality study within the OHDSI consortium were also presented. The second speaker (MK) described lessons learned and new data quality checks developed by the PEDsNet pediatric research network...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29180296/universal-lipid-screening-in-9-11-year-olds-before-and-after-2011-guidelines
#8
Nicole L Mihalopoulos, Carole Stipelman, Joni Hemond, Laura L Brown, Paul C Young
OBJECTIVE: To determine whether the 2011 guidelines for universal routine screening for dyslipidemia in children aged 9 to 11 years, published by the Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents and National Heart, Lung, and Blood Institute, are being followed by pediatric primary care providers. STUDY DESIGN: Retrospective data were obtained for 63,951 well-child visits (WCV) in children aged 9 to 11 years from two health care systems and one insurance program from 2009 to 2015...
November 24, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/29154806/crispr-cas9-licensing-the-unlicensable
#9
REVIEW
Ulrich Storz
A new gene engineering technology has recently made it through the media, not only because of its technical advantages, but also because it is in the focus of an epic patent battle between two academic institutions. The technology bears the cryptic name "CRISPR Cas9", and allows the manipulation of genes (so called "gene editing") with so far unseen simplicity and efficacy. Dana Carroll of the University of Utah said for this reason that CRISPR Cas9 has brought about the "democratization of gene targeting"...
November 14, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/29152493/a-pilot-study-evaluating-biomarker-development-for-drug-induced-chronic-eczematous-eruptions-of-aging-individuals
#10
Erika Mae Summers, Nicholas Ray Blickenstaff, Garrett Curtis Coman, Thomas Bernd Martins, Harry Raymond Hill, Richard Dennis Sontheimer
Background: Identifying the drug(s) responsible for drug-induced chronic eczematous eruptions of aging individuals (CEEA) is a clinical challenge in patients on multiple medications. Reliable in vitro testing methods and biomarkers are needed to identify the causative agent and allow simultaneous assessment of T-cell responses to multiple drugs being taken concurrently. This study examined the feasibility of using in vitro, drug-specific T cell activation responses as a biomarker for drug-induced CEEA...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29142086/shortage-of-generic-neurologic-therapeutics-an-escalating-threat-to-patient-care
#11
Jacklyn O Omorodion, Rami M Algahtani, Mark S Zocchi, Erin R Fox, Jesse M Pines, Henry J Kaminski
OBJECTIVE: To assess longitudinal trends in shortages of generic drugs used for neurologic conditions over a 15-year period in the United States. METHODS: Drug shortage data from the University of Utah Drug Information Service (UUDIS) from 2001 to 2015 were analyzed. Medications were included that were likely to be prescribed by a neurologist to treat a primary neurologic condition or critical for care of a patient with a neurologic condition. Trends in shortage length were assessed using standard descriptive statistics...
November 15, 2017: Neurology
https://www.readbyqxmd.com/read/29075017/assessment-of-a-novel-pinhole-supplementary-implant-for-sulcus-fixation-in-pseudophakic-cadaver-eyes
#12
K T Tsaousis, L Werner, C L C Trindade, J Guan, J Li, N Reiter
PurposeTo evaluate a novel small-aperture supplementary implant that applies the principle of pinholes for management of irregular astigmatism, in postmortem human eyes.MethodsPseudophakic human cadaver eyes were imaged by anterior segment optical coherence tomography (AS-OCT) to assess position of the in-the-bag intraocular lens (IOL). Eyes were prepared as per the Miyake-Apple technique. Two versions of the supplementary implant (open-loop and tripod designs) were then inserted into the sulcus of each eye...
October 27, 2017: Eye
https://www.readbyqxmd.com/read/29050658/addressing-health-disparities-from-within-the-community-community-based-participatory-research-and-community-health-worker-policy-initiatives-using-a-gender-based-approach
#13
Sara E Simonsen, Brenda Ralls, Anna Guymon, Teresa Garrett, Patricia Eisenman, Jeannette Villalta, O Fahina Tavake-Pasi, Valentine Mukundente, France A Davis, Kathleen Digre, Stephen Hayes, Stephanie Alexander
BACKGROUND: The Coalition for a Healthier Community for Utah Women and Girls (CHC-UWAG) focused on addressing obesity-related health disparities impacting Utah women of color using community-based participatory research, a gender-based approach, and culturally sensitive health promotion activities delivered through community health workers (CHWs). A randomized trial of low vs. high intensity wellness coaching by CHWs was initiated. During this process, numerous policy issues emerged and were tracked...
October 17, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29045274/recruiting-american-indian-alaska-native-students-to-medical-school-a-multi-institutional-alliance-in-the-u-s-southwest
#14
Marlene P Ballejos, Polly Olsen, Tanisha Price-Johnson, Cindy Garcia, Tassy Parker, Robert E Sapién, Valerie Romero-Leggott
PROBLEM: Despite national efforts to diversify the physician workforce, American Indian/Alaska Native (AI/AN) individuals have the least representation of all major racial and ethnic groups. Limited resources at state medical schools present institution-level recruitment challenges. Unified efforts to engage AI/AN students in premedical education activities are needed. APPROACH: The medical schools at the Universities of Arizona (Phoenix and Tucson), Colorado, New Mexico, and Utah identified a collective need to increase student diversity, particularly with regard to AI/AN students...
October 17, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29016990/age-and-sex-differences-in-atrial-fibrosis-among-patients-with-atrial-fibrillation
#15
Nazem Akoum, Christian Mahnkopf, Eugene G Kholmovski, Johannes Brachmann, Nassir F Marrouche
Aim: Age and female sex are associated with a higher risk of stroke in atrial fibrillation (AF). We sought to determine whether advancing age and female sex are associated with higher atrial fibrosis. Methods and results: We conducted an observational cohort study of patients with AF enrolled in the University of Utah AF Database and a non-AF control group who underwent late-gadolinium enhancement magnetic resonance imaging (LGE-MRI) for atrial fibrosis quantification...
August 9, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28991618/optimization-of-transversal-phacoemulsification-settings-in-peristaltic-mode-using-a-new-transversal-ultrasound-machine
#16
Dannen D Wright, Alex J Wright, Tyler D Boulter, Ashlie A Bernhisel, Brian C Stagg, Brian Zaugg, Jeff H Pettey, Larry Ha, Brian T Ta, Randall J Olson
PURPOSE: To determine the optimum bottle height, vacuum, aspiration rate, and power settings in the peristaltic mode of the Whitestar Signature Pro machine with Ellips FX tip action (transversal). SETTING: John A. Moran Eye Center Laboratories, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Porcine lens nuclei were hardened with formalin and cut into 2.0 mm cubes. Lens cubes were emulsified using transversal and fragment removal time (efficiency), and fragment bounces off the tip (chatter) were measured to determine optimum aspiration rate, bottle height, vacuum, and power settings in the peristaltic mode...
September 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28973094/effect-of-3-commercially-available-botulinum-toxin-neuromodulators-on-facial-synkinesis-a-randomized-clinical-trial
#17
Andrew J Thomas, Michael O Larson, Samuel Braden, Richard B Cannon, P Daniel Ward
Importance: Botulinum toxin neuromodulators are an important treatment for facial synkinesis. Whether a difference in efficacy exists among the 3 different botulinum neuromodulators used in treating this condition remains unknown. Objective: To evaluate the effectiveness of 3 commercially available botulinum toxin neuromodulators in the treatment of facial synkinesis. Design, Setting, and Participants: In this single-blind, 3-arm comparison randomized clinical trial, 28 patients at the Facial Nerve Center, University of Utah, Salt Lake City, were randomized to onabotulinumtoxinA, abobotulinumtoxinA, or incobotulinumtoxinA treatment...
September 28, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28970246/u-s-vaccine-and-immune-globulin-product-shortages-2001-15
#18
Victoria C Ziesenitz, Maryann Mazer-Amirshahi, Mark S Zocchi, Erin R Fox, Larissa S May
PURPOSE: Trends in shortages of vaccines and immune globulin products from 2001 through 2015 in the United States are described. METHODS: Drug shortage data from January 2001 through December 2015 were obtained from the University of Utah Drug Information Service. Shortage data for vaccines and immune globulins were analyzed, focusing on the type of product, reason for shortage, shortage duration, shortages requiring vaccine deferral, and whether the drug was a single-source product...
November 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28944731/the-fda-unapproved-drugs-initiative-an-observational-study-of-the-consequences-for-drug-prices-and-shortages-in-the-united-states
#19
Ravi Gupta, Sanket S Dhruva, Erin R Fox, Joseph S Ross
BACKGROUND: Hundreds of drug products are currently marketed in the United States without approval from the FDA. The 2006 Unapproved Drugs Initiative (UDI) requires manufacturers to remove these drug products from the market or obtain FDA approval by demonstrating evidence of safety and efficacy. Once the FDA acts against an unapproved drug, fewer manufacturers remain in the market, potentially enabling drug price increases and greater susceptibility to drug shortages. There is a need for systematic study of the UDI's effect on prices and shortages of all targeted drugs...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28917413/biocompatibility-of-intraocular-lens-power-adjustment-using-a-femtosecond-laser-in-a-rabbit-model
#20
Liliana Werner, Jason Ludlow, Jason Nguyen, Joah Aliancy, Larry Ha, Bryan Masino, Sean Enright, Ray K Alley, Ruth Sahler, Nick Mamalis
PURPOSE: To evaluate the biocompatibility (uveal and capsular) of intraocular lens (IOL) power adjustment by a femtosecond laser obtained through increased hydrophilicity of targeted areas within the optic, creating the ability to build a refractive-index shaping lens within an existing IOL. SETTING: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA. DESIGN: Experimental study. METHODS: Six rabbits had phacoemulsification with bilateral implantation of a commercially available hydrophobic acrylic IOL...
August 2017: Journal of Cataract and Refractive Surgery
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