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catechol-o-methyltransferase

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https://www.readbyqxmd.com/read/28640434/catechol-o-methyltransferase-genotype-and-gait-speed-changes-over-10-years-in-older-adults
#1
Andrea L Metti, Caterina Rosano, Robert Boudreau, Robyn Massa, Kristine Yaffe, Suzanne Satterfield, Tamara Harris, Andrea L Rosso
OBJECTIVES: To determine the association between catechol-O-methyltransferase (COMT) genotype and 6-m walk time and to determine whether these associations are quadratic in nature, similar to previously reported U-shaped associations between dopamine and gait and cognition. DESIGN: Prospective cohort study. SETTING: Health, Aging and Body Composition Study. PARTICIPANTS: Black (n = 850) and white (n = 1,352) men and women with a mean age of 73...
June 22, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28637770/analgesia-and-opioids-a-pharmacogenetics-shortlist-for-implementation-in-clinical-practice
#2
REVIEW
Maja Matic, Saskia N de Wildt, Dick Tibboel, Ron H N van Schaik
BACKGROUND: The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in dose requirements. Pharmacogenetics (PGx) could possibly be used to tailor pain medication based on an individual's genetic background. Many potential genetic markers have been described, and the importance of genetic predisposition in opioid efficacy and toxicity has been demonstrated in knockout mouse models and human twin studies. Such predictors are especially of value for neonates and young children, in whom the assessment of efficacy or side effects is complicated by the inability of the patient to communicate this properly...
June 21, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28635556/executive-control-in-schizophrenia-a-preliminary-study-on-the-moderating-role-of-comt-val158met-for-comorbid-alcohol-and-substance-use-disorders
#3
Giuseppe Carrà, Gabriella Nicolini, Cristina Crocamo, Annamaria Lax, Francesca Amidani, Francesco Bartoli, Filippo Castellano, Alessia Chiorazzi, Giulia Gamba, Costanza Papagno, Massimo Clerici
BACKGROUND: A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met) appears to influence cognition in people with alcohol/substance use disorders (AUD/SUD) and in those with psychosis. METHODS: To explore the potential moderating effect of these factors, a cross-sectional study was conducted, randomly recruiting subjects with DSM-IV diagnosis of schizophrenia. AUD/SUD was rigorously assessed, as well as COMT Val158Met polymorphism. Executive control functioning was measured using the Intra-Extra Dimensional Set Shift (IED)...
February 14, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28630452/remote-memories-are-enhanced-by-comt-activity-through-dysregulation-of-the-endocannabinoid-system-in-the-prefrontal-cortex
#4
D Scheggia, E Zamberletti, N Realini, M Mereu, G Contarini, V Ferretti, F Managò, G Margiani, R Brunoro, T Rubino, M A De Luca, D Piomelli, D Parolaro, F Papaleo
The prefrontal cortex (PFC) is a crucial hub for the flexible modulation of recent memories (executive functions) as well as for the stable organization of remote memories. Dopamine in the PFC is implicated in both these processes and genetic variants affecting its neurotransmission might control the unique balance between cognitive stability and flexibility present in each individual. Functional genetic variants in the catechol-O-methyltransferase (COMT) gene result in a different catabolism of dopamine in the PFC...
June 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28629779/are-dopaminergic-genotypes-risk-factors-for-eating-behavior-and-obesity-in-adults
#5
Orcun Avsar, Aysegul Kuskucu, Seda Sancak, Ece Genc
Dopamine (DA) is the main modulator of the brain reward system and significantly regulates food intake. The idea that obesity is a neurobiological disease rather than a metabolic disorder, is the basis of the study. Changes in dopamine neurotransmission affect the brain reward system in a direct way. Furthermore, changes in the reward system influence the eating behavior in human. The enzymes monoamine oxidase A (MAOA) and catechol-O-methyltransferase (COMT) terminate the DA function by metabolizing it. In our study, the control group which included 214 individuals and 234 subjects with obesity were investigated for MAOA-u VNTR and COMT (rs4680) polymorphisms...
June 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28625321/catechol-o-methyltransferase-gene-polymorphism-val158met-and-development-of-pre-eclampsia
#6
Ali Taravati, Fatemeh Tohidi, Mehrnaz Moniri, Kasra Kamali
OBJECTIVES: Catechol-O-methyltransferase (COMT) is a key enzyme in degradation pathways of estrogens and catecholamines. The present meta-analysis was done to elucidate the association of COMT Val158Met polymorphism with pre-eclampsia among pregnant women. METHODS: A literature search was conducted in electronic databases including PubMed, Scopus, Elsevier, Springer and Google Scholar to find eligible studies. The pooled odds ratios (ORs) with 95% confidence intervals were calculated under dominant, recessive, co-dominant, and allelic models...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28616971/lack-of-cell-proliferative-and-tumorigenic-effects-of-4-hydroxyestradiol-in-the-anterior-pituitary-of-rats-role-of-ultrarapid-o-methylation-catalyzed-by-pituitary-membrane-bound-catechol-o-methyltransferase
#7
Pan Wang, Laura H Mills, Ji-Hoon Song, Jina Yu, Bao-Ting Zhu
In animal models, estrogens are complete carcinogens in certain target sites. 4-Hydroxyestradiol (4-OH-E2), an endogenous metabolite of 17β-estradiol (E2), is known to have prominent estrogenic activity plus potential genotoxicity and mutagenicity. We report here our finding that 4-OH-E2 does not induce pituitary tumors in ACI female rats, whereas E2 produces 100% pituitary tumor incidence. To probe the mechanism, we conducted a short-term animal experiment to compare the proliferative effect of 4-OH-E2 in several organs...
June 15, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28614354/maternal-prenatal-anxiety-and-child-comt-genotype-predict-working-memory-and-symptoms-of-adhd
#8
Kieran J O'Donnell, Vivette Glover, Jari Lahti, Marius Lahti, Rachel D Edgar, Katri Räikkönen, Thomas G O'Connor
Maternal prenatal anxiety is an important risk factor for altered child neurodevelopment but there is uncertainty concerning the biological mechanisms involved and sources of individual differences in children's responses. We sought to determine the role of functional genetic variation in COMT, which encodes catechol-O-methyltransferase, in the association between maternal prenatal anxiety and child symptoms of ADHD and working memory. We used the prospectively-designed ALSPAC cohort (n = 6,969) for our primary data analyses followed by replication analyses in the PREDO cohort (n = 425)...
2017: PloS One
https://www.readbyqxmd.com/read/28610409/impact-of-catechol-o-methyltransferase-val-158met-rs4680-polymorphism-on-breast-cancer-susceptibility-in-asian-population
#9
Vandana Rai, Upendra Yadav, Pradeep Kumar
Background: Catechol-O-methyltransferase (COMT) is an important estrogen-metabolizing enzyme. Numerous case-control studies have evaluated the role COMT Val 158Met (rs4680;472G->A) polymorphism in the risk of breast cancer and provided inconclusive results, hence present meta-analysis was designed to get a more reliable assessment in Asian population. Methods: A total of 26 articles were identified through a search of four electronic databases- PubMed, Google Scholar, Science Direct and Springer link, up to March, 2016...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28608575/association-between-comt-val158met-and-psychiatric-disorders-a-comprehensive-meta-analysis
#10
Steven Taylor
Catechol-O-methyltransferase (COMT) Val158Met is widely regarded as potentially important for understanding the genetic etiology of many different psychiatric disorders. The present study appears to be the first comprehensive meta-analysis of COMT genetic association studies to cover all psychiatric disorders for which there were available data, published in any language, and with an emphasis on investigating disorder subtypes (defined clinically or by demographic or other variables). Studies were included if they reported one or more datasets (i...
June 13, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28608189/effect-of-catechol-o-methyltransferase-val158met-polymorphism-on-resting-state-brain-default-mode-network-after-acupuncture-stimulation
#11
Xuejuan Yang, Jie Gong, Lingmin Jin, Lin Liu, Jinbo Sun, Wei Qin
The effects of acupuncture can be characterized by clear individual differences. Several revealing studies suggest an underlying role of inherited genetic factor in interindividual variability in response to acupuncture treatment. It remains unclear, however, if the modulation of acupuncture on resting brain function is influenced by genetic factors. Catechol-o-methyltransferase (COMT) Val158Met polymorphism has been shown to regulate the resting brain network, especially in the default mode network (DMN), which is a target area that responds to acupuncture stimulation...
June 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28580819/opicapone-for-the-management-of-end-of-dose-motor-fluctuations-in-patients-with-parkinson-s-disease-treated-with-l-dopa
#12
Andrew J Lees, Joaquim Ferreira, Olivier Rascol, Heinz Reichmann, Fabrizio Stocchi, Eduardo Tolosa, Werner Poewe
Opicapone is a third generation, highly potent and effective catechol O‑methyltransferase (COMT) inhibitor that optimizes the pharmacokinetics and bioavailability of L-DOPA therapy. Areas covered: In this review, the authors describe the preclinical and clinical development of opicapone. In PD patients with motor fluctuations, once daily opicapone administration was well-tolerated and consistently reduced OFF-time and increased ON-time without increasing the frequency of troublesome dyskinesia, and these benefits were maintained over at least a year of continued open-label therapy...
June 5, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28556887/comt-val158met-and-mthfr-c677t-moderate-risk-of-schizophrenia-in-response-to-childhood-adversity
#13
J-C Debost, M Debost, J Grove, O Mors, D M Hougaard, A D Børglum, P B Mortensen, L Petersen
OBJECTIVE: Mesolimbic dopamine sensitization has been hypothesized to be a mediating factor of childhood adversity (CA) on schizophrenia risk. Activity of catechol-O-methyltransferase (COMT) Val158Met increases mesolimbic dopamine signaling and may be further regulated by methylenetetrahydrofolate reductase (MTHFR) C677T. This study investigates the three-way interaction between CA, COMT, and MTHFR. METHODS: We conducted a nested case-control study on individuals born after 1981, linking population-based registers to study the three-way interaction...
May 29, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28556830/adolescence-is-the-starting-point-of-sex-dichotomous-comt-genetic-effects
#14
S Sannino, M C Padula, F Managò, M Schaer, M Schneider, M Armando, E Scariati, F Sloan-Bena, M Mereu, M Pontillo, S Vicari, G Contarini, C Chiabrera, M Pagani, A Gozzi, S Eliez, F Papaleo
The catechol-o-methyltransferase (COMT) genetic variations produce pleiotropic behavioral/neuroanatomical effects. Some of these effects may vary among sexes. However, the developmental trajectories of COMT-by-sex interactions are unclear. Here we found that extreme COMT reduction, in both humans (22q11.2 deletion syndrome COMT Met) and mice (COMT-/-), was associated to cortical thinning only after puberty and only in females. Molecular biomarkers, such as tyrosine hydroxylase, Akt and neuronal/cellular counting, confirmed that COMT-by-sex divergent effects started to appear at the cortical level during puberty...
May 30, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28554414/treatment-strategies-in-early-parkinson-s-disease
#15
Luca Marsili, Roberto Marconi, Carlo Colosimo
The clinicians' approach to the treatment of early Parkinson's disease (PD) should take into account numerous aspects, including how to inform a patient upon diagnosis and the critical decision of what therapy to adopt and when to start it. The treatment of the motor disorder associated with early PD needs to consider several crucial factors, such as age at onset, comorbidities, and the patient's functional requirements, and cannot be summarized in a simple formula. In younger patients (i.e., before the age of 70) and in those without high functional requirements, treatment is usually initiated with dopamine agonists and/or monoamine oxidase-B enzyme inhibitors (MAO-B I)...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28545007/catechol-o-methyltransferase-gene-promoter-methylation-as-a-peripheral-biomarker-in-male-schizophrenia
#16
S Gao, J Cheng, G Li, T Sun, Y Xu, Y Wang, X Du, G Xu, S Duan
As an epigenetic modification, DNA methylation may reflect the interaction between genetic and environmental factors in the development of schizophrenia (SCZ). Catechol-O-methyltransferase (COMT) gene is a promising candidate gene of SCZ. In the present study, we investigate the association of COMT methylation with the risk of SCZ using bisulfite pyrosequencing technology. Significant association between DNA methylation of COMT and the risk of SCZ is identified (P=1.618e-007). A breakdown analysis by gender shows that the significance is driven by males (P=3...
March 30, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28544426/the-catechol-o-methyltransferase-comt-val158met-genotype-modulates-working-memory-related-dorsolateral-prefrontal-response-and-performance-in-bipolar-disorder
#17
K W Miskowiak, H L Kjaerstad, M M Støttrup, A M Svendsen, K M Demant, L K Hoeffding, T M Werge, K E Burdick, K Domschke, A F Carvalho, E Vieta, M Vinberg, L V Kessing, H R Siebner, J Macoveanu
OBJECTIVES: Cognitive dysfunction affects a substantial proportion of patients with bipolar disorder (BD), and genetic-imaging paradigms may aid in the elucidation of mechanisms implicated in this symptomatic domain. The Val allele of the functional Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene is associated with reduced prefrontal cortex dopamine and exaggerated working memory-related prefrontal activity. This functional magnetic resonance imaging (fMRI) study investigated for the first time whether the COMT Val158Met genotype modulates prefrontal activity during spatial working memory in BD...
May 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28536775/catechol-o-methyltransferase-and-udp-glucuronosyltransferases-in-the-metabolism-of-baicalein-in-different-species
#18
Ruiya Zhang, Yonglei Cui, Yan Wang, Xiangge Tian, Lu Zheng, HaiJian Cong, Bin Wu, Xiaokui Huo, Chao Wang, BaoJing Zhang, Xiaobo Wang, Zhonghui Yu
BACKGROUND: Baicalein is the major bioactive flavonoid in some herb medicines and dietary plants; however, the detailed metabolism pathway of its major metabolite oroxylin A-7-O-β-D-glucuronide in human was not clear. It was important to illustrate the major metabolic enzymes that participate in its elimination for the clinic use of baicalein. OBJECTIVES: We first revealed a two-step metabolism profile for baicalein and illustrated the combination of catechol-O-methyltransferase (COMT) and uridine diphosphate-glucuronosyltransferases (UGTs) in drug metabolism, further evaluated its bioactivity variation during drug metabolism...
May 23, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28526448/the-catechol-o-methyltransferase-inhibitors-tolcapone-and-entacapone-uncouple-and-inhibit-the-mitochondrial-respiratory-chain-in-heparg-cells
#19
David Grünig, Andrea Felser, Jamal Bouitbir, Stephan Krähenbühl
The catechol-O-methyltransferase inhibitor tolcapone causes hepatotoxicity and mitochondrial damage in animal models. We studied the interaction of tolcapone with mitochondrial respiration in comparison to entacapone in different experimental models. In HepaRG cells (human cell-line), tolcapone decreased the ATP content (estimated IC50 100±15μM) and was cytotoxic (estimated IC50 333±45μM), whereas entacapone caused no cytotoxicity and no ATP depletion up to 200μM. Cytochrome P450 induction did not increase the toxicity of the compounds...
May 16, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28523234/the-effect-of-comt-val158met-and-drd2-c957t-polymorphisms-on-executive-function-and-the-impact-of-early-life-stress
#20
Kristel Klaus, Kevin Butler, Simon J Durrant, Manir Ali, Chris F Inglehearn, Timothy L Hodgson, Humberto Gutierrez, Kyla Pennington
INTRODUCTION: Previous research has indicated that variation in genes encoding catechol-O-methyltransferase (COMT) and dopamine receptor D2 (DRD2) may influence cognitive function and that this may confer vulnerability to the development of mental health disorders such as schizophrenia. However, increasing evidence suggests environmental factors such as early life stress may interact with genetic variants in affecting these cognitive outcomes. This study investigated the effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress in healthy adults...
May 2017: Brain and Behavior
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