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catechol-o-methyltransferase

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https://www.readbyqxmd.com/read/29760667/a-drd2-annk1-comt-interaction-consisting-of-functional-variants-confers-risk-of-post-traumatic-stress-disorder-in-traumatized-chinese
#1
Kunlin Zhang, Li Wang, Chengqi Cao, Gen Li, Ruojiao Fang, Ping Liu, Shu Luo, Xiangyang Zhang, Israel Liberzon
Objective: Post-traumatic stress disorder (PTSD) is a trauma- and stress-related psychiatric syndrome that occurs after exposure to extraordinary stressors. The neurotransmitter dopamine (DA) plays important roles in neurobiological processes like reward and stress, and a link between PTSD and the dopaminergic system has been reported. Thus, the investigation of an association between PTSD and gene-gene interaction (epistasis) within dopaminergic genes could uncover the genetic basis of dopamine-related PTSD symptomatology and contribute to precision medicine...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29730044/association-between-catechol-o-methyltransferase-genetic-variation-and-functional-connectivity-in-patients-with-first-episode-schizophrenia
#2
Hongyan Wang, Bin Zhang, Botao Zeng, Yingying Tang, Tianhong Zhang, Shanshan Zhao, Chunbo Li, Jijun Wang, Donald C Goff
Dopamine in the prefrontal cortex (PFC) plays an important role in cognitive performance and regulates by catechol-O-methyltransferase (COMT) expression. To clarify the effect of COMT genotype on cognitive function in patients with schizophrenia, we performed DNA genotyping, cognitive evaluations, and functional magnetic resonance imaging (fMRI) in antipsychotic-naïve patients with first-episode schizophrenia (FES) and matched healthy control subjects. We found that all cognitive domains were impaired in patients with FES compared with healthy subjects...
May 3, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29707715/effects-of-bovine-lactoferrin-on-l-dopa-absorption-and-metabolism-in-mice
#3
Masayuki Ikeda, Hiroshi Iijima, Ichizo Shinoda, Hiroshi Iwamoto, Yasuhiro Takeda
Bioactive natural products, habitually ingested with milk or its derivative nutrients, have been studied for their bioavailability. In this study, we investigated the effects of the co-administration of bovine milk-derived lactoferrin (bLF) and bioactive products, with a focus on catechol-O-methyltransferase (COMT), an enzyme in the catechol metabolism. bLF showed inhibitory activity on COMT in vitro, and acidic pretreatment of bLF enhanced its inhibitory activity. Moreover, partially digested products of bLF by pepsin retained inhibitory activity...
April 30, 2018: Food & Function
https://www.readbyqxmd.com/read/29703646/striatal-dopamine-release-and-impaired-reinforcement-learning-in-adults-with-22q11-2-deletion-syndrome
#4
Esther D A van Duin, Zuzana Kasanova, Dennis Hernaus, Jenny Ceccarini, Alexander Heinzel, Felix Mottaghy, Siamak Mohammadkhani-Shali, Oliver Winz, Michael Frank, Merrit C H Beck, Jan Booij, Inez Myin-Germeys, Thérèse van Amelsvoort
22q11.2 deletion syndrome (22q11DS) is a genetic disorder caused by a microdeletion on chromosome 22q11.2 and associated with an increased risk for developing psychosis. The catechol-O-methyltransferase (COMT) gene is located in the deleted region and involved in dopamine (DA) breakdown. Impaired reinforcement learning (RL) is a recurrent feature in psychosis and thought to be related to abnormal striatal DA function. This study aims to examine RL and the potential association with striatal DA-ergic neuromodulation in 22q11DS...
April 24, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29697034/nitrocatechol-derivatives-of-chalcone-as-inhibitors-of-monoamine-oxidase-and-catechol-o-methyltransferase
#5
Idalet Engelbrecht, Jacobus P Petzer, Anel Petzer
The efficacy of L-dopa in the treatment of Parkinson's disease depends on its metabolic conversion to dopamine in the brain, however extensive peripheral metabolism of L-dopa diminishes its availability for uptake into the brain. L-Dopa is extensively decarboxylated in the gastrointestinal tract and peripheral tissues by aromatic L-amino acid decarboxylase (AADC), and AADC inhibitors are thus frequently combined with L-dopa therapy. When AADC is inhibited, 3-O-methylation catalysed by catechol-O-methyltransferase (COMT) becomes a dominant metabolic pathway for L-dopa, and COMT inhibitors may thus also be used as adjuncts to L-dopa in Parkinson's disease...
April 26, 2018: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29692704/left-parietal-functional-connectivity-mediates-the-association-between-comt-rs4633-and-verbal-intelligence-in-healthy-adults
#6
Qiang Xu, Jilian Fu, Feng Liu, Wen Qin, Bing Liu, Tianzi Jiang, Chunshui Yu
In Chinese Han population, Catechol-O-methyltransferase gene ( COMT) rs4633 is found to be associated with impaired cognitive process. We aimed to investigate the association between COMT rs4633 and verbal intelligence and the underlying neural mechanisms in Chinese Han healthy young adults. In 256 Chinese Han healthy young adults, we explored the modulatory effects of COMT rs4633 on verbal intelligence quotient (VIQ) and functional connectivity density (FCD) of the brain and the mediation effect of FCD on the association between COMT and VIQ...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29688484/effect-of-the-catechol-o-methyltransferase-inhibitors-tolcapone-and-entacapone-on-fatty-acid-metabolism-in-heparg-cells
#7
David Grünig, Andrea Felser, Urs Duthaler, Jamal Bouitbir, Stephan Krähenbühl
Tolcapone and entacapone are catechol-O-methyltransferase (COMT) inhibitors used in patients with Parkinson's disease. For tolcapone, patients with liver failure have been reported with microvesicular steatosis observed in the liver biopsy of one patient. We therefore investigated the impact of tolcapone and entacapone on fatty acid metabolism in HepaRG cells exposed for 24 hours and on acutely exposed mouse liver mitochondria. In HepaRG cells, tolcapone induced lipid accumulation starting at 100µM, whereas entacapone was ineffective up to 200µM...
April 23, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29680514/brain-blood-cerebrospinal-fluid-and-serum-biomarkers-in-schizophrenia
#8
REVIEW
Alireza Mohammadi, Ehsan Rashidi, Vahid Ghasem Amooeian
Over the last decade, finding a reliable biomarker for the early detection of schizophrenia (Scz) has been a topic of interest. The main goal of the current review is to provide a comprehensive view of the brain, blood, cerebrospinal fluid (CSF), and serum biomarkers of Scz disease. Imaging studies have demonstrated that the volumes of the corpus callosum, thalamus, hippocampal formation, subiculum, parahippocampal gyrus, superior temporal gyrus, prefrontal and orbitofrontal cortices, and amygdala-hippocampal complex were reduced in patients diagnosed with Scz...
April 13, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29677196/catechol-o-methyltransferase-moderates-effect-of-stress-mindset-on-affect-and-cognition
#9
Alia J Crum, Modupe Akinola, Bradley P Turnwald, Ted J Kaptchuk, Kathryn T Hall
There is evidence that altering stress mindset-the belief that stress is enhancing vs. debilitating-can change cognitive, affective and physiological responses to stress. However individual differences in responsiveness to stress mindset manipulations have not been explored. Given the previously established role of catecholamines in both placebo effects and stress, we hypothesized that genetic variation in catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, would moderate responses to an intervention intended to alter participants' mindsets about stress...
2018: PloS One
https://www.readbyqxmd.com/read/29670409/safinamide-an-add-on-treatment-for-managing-parkinson-s-disease
#10
REVIEW
Thomas Müller
Heterogeneous expression of neurotransmitter deficits results from onset and progression of Parkinson's disease. Intervals, characterized by reappearance of motor and associated certain nonmotor symptoms, determine the end of good tolerability and efficacy of oral levodopa therapy. These "OFF" states result from levodopa pharmacokinetics and disease progression-related deterioration of the central buffering capacity for fluctuations of dopamine levels. This review discusses safinamide as an add-on therapeutic agent in orally levodopa-treated patients with "OFF" phenomena...
2018: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/29627597/genetic-pathways-to-posttraumatic-stress-disorder-and-depression-in-children-investigation-of-catechol-o-methyltransferase-comt-val158met-using-different-ptsd-diagnostic-models
#11
BreAnne A Danzi, Annette M La Greca
The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been linked to PTSD, although findings have been inconsistent. Recently, different diagnostic criteria for PTSD have been introduced by ICD-11 and DSM-5, including separate criteria for adults and for young children (i.e., the preschool criteria). The preschool criteria may be applicable to older children as well. This study is the first to examine COMT associations with depression and PTSD, using new diagnostic models, in school-age children (7-11 years) exposed to a natural disaster...
March 27, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29623060/perceived-stress-in-adults-aged-65-to-90-relations-to-facets-of-time-perspective-and-comt-val-158-met-polymorphism
#12
Michael Rönnlund, Elisabeth Åström, Rolf Adolfsson, Maria G Carelli
This study examined the relation between perceived stress and time perspective (views of past, present, future) in a population-based sample of older adults (65-90 years, N = 340). The Perceived Questionnaire (PSQ index) was used to measure stress and the Swedish version of the Zimbardo Time Perspective Inventory (S-ZTPI) was used to operationalize time perspective. Unlike the original inventory, S-ZTPI separates positive and negative aspects of a future time perspective and we hypothesized that the Future Negative (FN) scale would be important to account for variations in stress...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29614697/are-there-benefits-in-adding-catechol-o-methyltransferase-inhibitors-in-the-pharmacotherapy-of-parkinson-s-disease-patients-a-systematic-review
#13
Irene Katsaiti, John Nixon
BACKGROUND: A qualified consensus suggests that a combination of levodopa with a peripherally acting dopa decarboxylase inhibitor continues to present the gold standard treatment of Parkinson's disease (PD). However, as the disease progresses the therapeutic window of levodopa becomes narrowed. Pharmacological strategies for motor fluctuations are focused on providing less pulsatile and more continuous dopaminergic stimulation. Peripheral catechol-O-methyltransferase (COMT) inhibition improves the bioavailability of levodopa and results in a prolonged response...
March 26, 2018: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29594134/the-comt-val158met-polymorphism-and-exploratory-behavior-in-bipolar-mania
#14
Arpi Minassian, Jared W Young, Mark A Geyer, John R Kelsoe, William Perry
Background: The catechol-O-methyltransferase (COMT) Val158Met gene influences cognition and behavior in psychiatric illnesses; its low-activity allele, methionine (Met), may be associated with behavior reflecting catecholamine overactivity. Heightened motor activity and increased positive valence are central features of bipolar disorder (BD) and have been quantified in the human Behavioral Pattern Monitor (hBPM), an exploration paradigm based upon the rodent open field. We examined whether hBPM behavior was related to the COMT gene in a small sample of manic BD patients...
February 2018: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/29575277/association-study-of-functional-polymorphisms-of-dopaminergic-pathway-in-epilepsy-related-factors-of-temporal-lobe-epilepsy-in-brazilian-population
#15
Juliana A Alcantara, Silvia Vincentiisa, Daniel S Kerr, Bernardo Dos Santos, Ruda Alessi, Helio van der Linden, Tiffany Chaim, Maurício H Serpa, Geraldo Busatto, Wagner F Gattaz, Renata Demarque, Kette Dr Valente
BACKGROUND: There is scarce data about the role of neurotransmission modulated by dopamine (DA) in epilepsy, especially temporal lobe epilepsy. This is the first study that aimed to analyze the dopaminergic polymorphisms in an etiologically homogeneous group of patients with temporal lobe epilepsy determined by hippocampal sclerosis (TLE-HS). Selected polymorphisms were: (i) the most expressed receptors in the limbic system D2-like (DRD2/ANKK1 TAQ-1A, D4_VNTR, and D4_rs1800955); (ii) the dopamine transporter DAT - 3 'untranslated region (3'UTR) and Intron 8; (iii) two degrading enzymes regulating the synaptic activity - the main metabolizer of dopamine Catechol-O-methyltransferase (COMT) and monoamine oxidase A (MAOA)...
March 25, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29574383/interplay-between-comt-val158met-childhood-adversities-and-sex-in-predicting-panic-pathology-findings-from-a-general-population-sample
#16
Eva Asselmann, Johannes Hertel, Katja Beesdo-Baum, Carsten-Oliver Schmidt, Georg Homuth, Matthias Nauck, Hans-Jörgen Grabe, Christiane A Pané-Farré
BACKGROUND: The single nucleotide polymorphism rs4680 of the catechol-O-methyltransferase (COMT) gene has been implicated to be involved in the etiopathogenesis of panic. However, it remains unresolved whether rs4680 modifies the risk-association between early life stress and subsequent development of panic pathology. METHODS: The genotype of rs4680 was determined for n = 2242 adults with European ancestry from the Study of Health in Pomerania (SHIP, a regional longitudinal cohort study from northeastern Germany)...
March 8, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29559808/association-of-genetic-variation-in-comt-gene-with-pain-related-to-sickle-cell-disease-in-patients-from-the-walk-phasst-study
#17
Yingze Zhang, Inna Belfer, Mehdi Nouraie, Qilu Zeng, Ruchika Goel, Yanxia Chu, Inna Krasiy, Lakshmanan Krishnamurti
Background: Vaso-occlusive pain episodes (VOEs) are the hallmark of sickle cell disease (SCD), and our current understanding of disease biology, treatment, and psychological covariates does not adequately explain the variability of pain in SCD. Functional variants in catechol- O -methyltransferase ( COMT ) gene contribute to variability in pain perception, but their impact on pain perception in African American SCD patients is not well known. Methods: We studied COMT single-nucleotide polymorphisms (SNPs) rs6269, rs4633, rs4818, rs4680, and rs165599 to determine their relationship to patient self-reported pain, the number of acute VOEs, and their impact on daily life and health care utilization in 438 hemoglobin SS patients who participated in the walk-PHaSST study...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29550002/pulp-sensitivity-influence-of-sex-psychosocial-variables-comt-gene-and-chronic-facial-pain
#18
Irena Mladenovic, Jelena Krunic, Gordana Supic, Ruzica Kozomara, Dejan Bokonjic, Nikola Stojanovic, Zvonko Magic
INTRODUCTION: The purpose of this study was to evaluate the associations of variability in pulp sensitivity with sex, psychosocial variables, the gene that encodes for the enzyme catechol-O-methyltransferase (COMT), and chronic painful conditions (temporomandibular disorders [TMDs]). METHODS: The study was composed of 97 subjects (68 women and 29 men aged 20-44 years). The electric (electric pulp tester) and cold (refrigerant spray) stimuli were performed on mandibular lateral incisors...
March 14, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29514826/-n-methylation-of-bi-187004-by-thiol-s-methyltransferase
#19
Hlaing H Maw, Xingzhong Zeng, Scot Campbell, Mitchell E Taub, Aaron M Teitelbaum
BI 187004, an 11 β -hydroxysteroid dehydrogenase 1 inhibitor, was administered once daily for 14 days to eight patients with type 2 diabetes mellitus. N -methylation was identified as a major biotransformation pathway. In four patients treated with BI 187004, the plasma exposure of an N -methylbenzimidazole metabolite [ N -methylbenzimidazole regioisomer 1 (M1)] was 7-fold higher than the remaining four patients, indicating a substantial degree of metabolic variation. To identify the methyltransferase enzymes responsible for N -methylation, BI 187004 was incubated with human liver microsomes (HLM), human kidney microsomes (HKM), and their respective cytosolic preparations in the presence and absence of isoform-selective chemical inhibitors...
June 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29496635/quantitative-analysis-of-catecholamines-in-the-pink1-rat-model-of-early-onset-parkinson-s-disease
#20
Cynthia A Kelm-Nelson, Michael A Trevino, Michelle R Ciucci
Parkinson's disease (PD) related to homozygous mutations in the Pink1 gene is associated with nigrostriatal dopamine depletion and a wide range of sensorimotor deficits. In humans and animal models of PD, not all sensorimotor deficits are levodopa-responsive. We hypothesized that the underlying mechanisms of locomotion, limb control, and vocal communication behavior include other pathologies. Here, Pink1 -/- rats were treated with an oral dose of levodopa and limb motor and vocal communication behaviors were measured...
May 21, 2018: Neuroscience
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