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https://www.readbyqxmd.com/read/29222650/taxane-platinum-and-5-fu-prior-to-chemoradiotherapy-benefits-patients-with-stage-iv-neck-node-positive-head-and-neck-cancer-and-a-good-performance-status
#1
Natalie M Lowe, Jonathan M Bernstein, Kathleen Mais, Kate Garcez, Lip W Lee, Andrew Sykes, David J Thomson, Jarrod J Homer, Catharine M West, Nicholas J Slevin
PURPOSE: The benefit of adding docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy to chemoradiotherapy (CRT) in head and neck squamous cell carcinoma (HNSCC) remains uncertain. We aimed to investigate whether ICT is well tolerated when given with prophylactic treatment against predicted adverse effects and which patients benefit most. METHODS: A single-centre audit identified 132 HNSCC patients with stage IVa/b neck node-positive disease, prescribed TPF followed by CRT...
December 8, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29221990/molecular-and-cellular-mechanisms-of-chemoresistance-in-pancreatic-cancer
#2
REVIEW
Aleksandra Adamska, Omar Elaskalani, Aikaterini Emmanouilidi, Minkyoung Kim, Norbaini Binti Abdol Razak, Pat Metharom, Marco Falasca
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most chemoresistant cancers, and current therapies targeting cancer-associated molecular pathways have not given satisfactory results, owing in part to rapid upregulation of alternative compensatory pathways. Most of the available treatments are palliative, focussing on improving the quality of life. At present, available options are surgery, embolization, radiation, chemotherapy, immunotherapy and use of other more targeted drugs. In this review, we describe the cellular and molecular effects of current chemotherapy drugs such as gemcitabine, FOLFIRINOX (5-fluorouracil [5-FU], oxaliplatin, irinotecan, and leucovorin) and ABRAXANE (nab-Paclitaxel), which have shown a survival benefit, although modest, for pancreatic cancer patients...
November 22, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/29221215/dnmt1-overexpression-predicting-gastric-carcinogenesis-subsequent-progression-and-prognosis-a-meta-and-bioinformatic-analysis
#3
Tianmiao Ma, Hao Li, Mingjun Sun, Yuan Yuan, Li-Ping Sun
DNMT1 is important in maintaining DNA methylation, and participates in the oncogenesis via up- or down-regulation leading to hyper-methylation or hypo-methylation. In the meta and bioinformatic analysis, we found that DNMT1 expression was higher in gastric cancer, compared with normal (p < 0.00001), para-cancerous (p = 0.0004) and dysplasia (p < 0.00001) tissues. DNMT1 up-regulation was associated with gender (OR = 2.27, p = 0.006), differentiation (OR = 0.21, p = 0.01) and TNM stage (OR = 0.31, p = 0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220692/plag-alleviates-chemotherapy-induced-thrombocytopenia-via-promotion-of-megakaryocyte-erythrocyte-progenitor-differentiation-in-mice
#4
Ha-Reum Lee, Nina Yoo, Jinseon Jeong, Ki-Young Sohn, Sun Young Yoon, Jae Wha Kim
Previously, PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol, acetylated diglyceride) was reported to have an effect on the proliferation of hematopoietic stem cells (HSCs) or to contribute to the prevention of chemotherapy-induced neutropenia. In this study, we examined the role of PLAG in the differentiation of bone marrow cells from HSCs into progenitor cells in mice. After 15days, the lineage-negative cells, especially megakaryocyte/erythrocyte progenitors (MEP), were significantly increased in mice that received daily PLAG administration compared to those in the untreated mice...
October 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29218650/structural-characterization-and-in-vitro-antitumor-activity-of-a-novel-exopolysaccharide-from-lachnum-ym130
#5
Ping Xu, Ruyue Yuan, Guohua Hou, Jinglei Li, Ming Ye
Exopolysaccharide of Lachnum YM130 (LEP) was purified by diethylaminoethyl cellulose 52 and Sepharose CL-6B column chromatography. LEP-2a was identified to be a homogeneous component with an average molecular weight of 1.31 × 106 Da, which was consisted of mannose and galactose in a molar ratio of 3.8:1.0. The structure of LEP-2a was characterized by methylation analysis, FT-IR analysis, and NMR analysis. Results indicated that LEP-2a was a galactomannan with a backbone, composed of 1,2-linked-α-D-Manp, 1,2,6-linked-α-D-Manp, 1,3,4-linked-α-D-Manp, and 1,3-linked-β-D-Galp, which was substituted at O-2, O-3, O-4, and O-6 by branches...
December 8, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29215740/the-stat3-nfil3-signaling-axis-mediated-chemotherapy-resistance-is-reversed-by-raddeanin-a-via-inducing-apoptosis-in-choriocarcinoma-cells
#6
Zheng Peng, Chun Zhang, Wenjun Zhou, Chenchun Wu, Yi Zhang
OBJECTIVE: Chemotherapy resistance is the major issue of choriocarcinoma. Apoptosis always is the ultimate outcome of chemotherapeutic drugs, which considered one of the reasons of resistance. We investigated the role of STAT3/NFIL3 signaling-inhibited apoptosis in chemotherapy resistance and whether Raddeanin A (RA) could be a new drug to reverse resistance. METHODS: Established three drug-resistant cell lines as JEG-3/MTX, JEG-3/5-FU and JEG-3/VP16. NFIL3 and STAT3 expression was evaluated in the cells...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29212821/trabeculectomy-bleb-needling-and-antimetabolite-administration-practices-in-the-uk-a-glaucoma-specialist-national-survey
#7
Karl Mercieca, Brett Drury, Archana Bhargava, Cecilia Fenerty
AIMS: To evaluate, describe and quantify the diversity in postoperative antimetabolite administration and bleb needling practices among glaucoma specialists performing trabeculectomy surgery within the UK and Ireland. METHODS: A cross-sectional online survey was distributed to all consultant glaucoma specialists who are on the United Kingdom and Eire Glaucoma Society (UKEGS) contact list. Participants were asked specific questions about their current practices for post-trabeculectomy antimetabolite administration followed by questions directly related to bleb needling procedures...
December 6, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29210057/a-functional-polymorphism-in-tff1-promoter-is-associated-with-the-risk-and-prognosis-of-gastric-cancer
#8
Weizhi Wang, Zheng Li, Jiwei Wang, Mulong Du, Bowen Li, Lei Zhang, Qing Li, Jianghao Xu, Linjun Wang, Fengyuan Li, Diancai Zhang, Hao Xu, Li Yang, Weida Gong, Fulin Qiang, Zhengdong Zhang, Zekuan Xu
Trefoil Factor 1 (TFF1, also named pS2), which serves as the gastrointestinal mucosal protector, is known as gastric-specific tumor suppressor gene. However, the genetic variants of TFF1 are still not well studied. In this study, we aim to explore the effects of tagging single nucleotide polymorphisms (tagSNPs) of TFF1 on risk and prognosis of gastric cancer. Seven tagSNPs of TFF1 gene were first analyzed in the test set, which was consisted of 753 cases and 950 cancer-free controls. Then, the validation set (940 cases and 1,042 controls) was used for further evaluation...
December 6, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29209657/hitting-the-snooze-button-inducing-quiescence-with-the-flt3-inhibitor-quizartinib-protects-hematopoietic-progenitors-from-chemotherapy
#9
Samuel J Taylor, Wallace Y Langdon
Myelosuppression is one of the most severe and limiting side effects of chemotherapy. Our recent work outlines a strategy to prevent chemotherapy-induced myelosuppression by administering a priming dose of the FMS-Like Tyrosine kinase 3 (FLT3) inhibitor quizartinib. Furthermore, by administering sequential quizartinib primed injections of fluorouracil (5-FU), we demonstrated a novel and effective strategy to eliminate disease in two mouse models of quizartinib resistant acute myeloid leukemia (AML).
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/29207609/reciprocal-regulation-of-dgcr5-and-mir-320a-affects-the-cellular-malignant-phenotype-and-5-fu-response-in-pancreatic-ductal-adenocarcinoma
#10
Sun Yong, Yu Yabin, Zhou Bing, Zhu Chuanrong, Gu Dianhua, Zhang Jianhuai, Yuan Weidong, Wang Shuming, Liu Ling
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies. Long non-coding microRNAs (lncRNAs) are a newly discovered type of regulatory molecule with both diagnostic and prognostic value, but the role of lncRNA in PDAC has not been well investigated until now. Here, we present evidence that shows that the lncRNA DGCR5 is significantly reduced in PDAC tissues as well as in PDAC cell lines and that the downregulation of DGCR5 predicts poor prognosis. Ectopic expression of DGCR5 inhibits the proliferation and migration, and promotes 5-FU resistances of PDAC cells...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207336/cytotoxicity-molecular-modeling-cell-cycle-arrest-and-apoptotic-induction-induced-by-novel-tetrahydro-1-2-4-triazolo-3-4-a-isoquinoline-chalcones
#11
Magda F Mohamed, Hamdi M Hassaneen, Ismail A Abdelhamid
Novel tetrahydro-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)-3-arylprop-2-en-1-one derivatives were synthesized and their structures were confirmed by different spectral tools. Cytotoxicity test revealed that some compounds exhibited strong to moderate effect, while others showed weak action against different cancer cell lines (MCF7, A549, HCT116, and Hepg2). Breast carcinoma revealed higher sensitivity toward all derivatives especially compounds 5 and 8 which offered the lowest IC50 values (50.05, and 27.15 μg/ml) respectively, relative to the positive control 5-fluorouracil (5-FU) (IC50 = 178 μg/ml)...
November 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29202398/synthesis-and-biological-characterization-of-ubenimex-fluorouracil-conjugates-for-anti-cancer-therapy
#12
Yuqi Jiang, Xiaoyang Li, Jinning Hou, Yongxue Huang, Xuejian Wang, Yuping Jia, Qingwei Wang, Wenfang Xu, Jian Zhang, Yingjie Zhang
Previously a novel ubenimex-fluorouracil (5-FU) conjugate, BC-01 was identified and validated as a potent CD13 inhibitor with marked in vitro and in vivo antitumor potency. Herein, further structural modifications of the linker part of BC-01 was carried out to get more potent and stable ubenimex-fluorouracil conjugates. It was striking that most of these conjugates showed even more potent CD13 inhibitory activities than BC-01 and the approved CD13 inhibitor ubenimex. One representative compound 12a displayed significant in vitro anti-proliferation, pro-apoptosis, anti-metastasis, anti-angiogenesis and CD13+ cell elimination effects...
November 30, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29200967/pharmacological-inhibition-of-bmi1-by-ptc-209-impaired-tumor-growth-in-head-neck-squamous-cell-carcinoma
#13
Qiong Wang, Zhongwu Li, Yaping Wu, Rong Huang, Yumin Zhu, Wei Zhang, Yanling Wang, Jie Cheng
Background: Bmi1 (B lymphoma Mo-MLV insertion region 1 homolog) contributes to human tumorigenesis via epigenetic transcriptional silencing and represents a novel therapeutic target with great potentials. Here we sought to determine the therapeutic efficiency of PTC-209, a potent and selective Bmi1 inhibitor, in head neck squamous cell carcinoma (HNSCC) cells and a HNSCC xenograft model. Methods: The mutation pattern, mRNA level of Bmi1 in HNSCC and its associations with clinicopathological parameters were determined through comprehensive data mining and interrogation using publicly available databases GENT, cBioPortal, Oncomine and TCGA...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29200845/solid-lipid-nanoparticles-for-thermoresponsive-targeting-evidence-from-spectrophotometry-electrochemical-and-cytotoxicity-studies
#14
Mubashar Rehman, Ayesha Ihsan, Asadullah Madni, Sadia Zafar Bajwa, Di Shi, Thomas J Webster, Waheed S Khan
Thermoresponsive drug delivery systems are designed for the controlled and targeted release of therapeutic payload. These systems exploit hyperthermic temperatures (>39°C), which may be applied by some external means or due to an encountered symptom in inflammatory diseases such as cancer and arthritis. The objective of this paper was to provide some solid evidence in support of the hypothesis that solid lipid nanoparticles (SLNs) can be used for thermoresponsive targeting by undergoing solid-liquid phase transition at their melting point (MP)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29200829/andrographolide-enhanced-5-fluorouracil-induced-antitumor-effect-in-colorectal-cancer-via-inhibition-of-c-met-pathway
#15
Meng Su, Baoli Qin, Fang Liu, Yuze Chen, Rui Zhang
Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. 5-Fluorouracil (5-Fu) is the most important chemotherapeutic drug used for the treatment of CRC. However, resistance to 5-Fu therapies is a growing concern in CRC clinical practice recently. Andrographolide (Andro) is a main bioactive constituent of the herb Andrographis paniculata, which has various biological effects including anti-inflammation and antitumor activities. In the present study, we investigated the effects of combined Andro with 5-Fu against CRC HCT-116 cells...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29199720/a-prospective-randomized-trial-comparing-capecitabine-based-chemoradiotherapy-with-5-fu-based-chemoradiotherapy-in-neoadjuvant-setting-in-locally-advanced-carcinoma-rectum
#16
K Singh, M K Gupta, R K Seam, M Gupta
INTRODUCTION: Fluorouracil (FU)based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. Capecitabine is an oral fluoropyrimidine that generates 5FU preferentially at the tumor site by exploiting the higher activity of the enzyme thymidine phosphorylase in tumor tissue compared with healthy tissue. As an oral agent, capecitabine can be administered in the outpatient setting, potentially providing FU exposure similar to a lowdose continuous infusion of 5FU...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199237/active-ingredients-of-hange-shashin-to-baicalelin-and-6-gingerol-inhibit-5-fluorouracil-induced-upregulation-of-cxcl1-in-the-colon-to-attenuate-diarrhea-development
#17
Hiroyasu Sakai, Shoko Tabata, Minami Kimura, Saori Yabe, Yosuke Isa, Yuki Kai, Fumiaki Sato, Tetsuro Yumoto, Kanako Miyano, Minoru Narita, Yasuhito Uezono
5-Fluorouracil (5-FU) is widely used as an anti cancer drug and is known to cause severe diarrhea. Recently we suggested that levels of chemokine (C-X-C motif) ligand 1 (CXCL1) and neutrophil recruitment in the colonic mucosa were drastically increased by the 5-FU administration in mice. Hange-shashin-to (HST) is prescribed in Japan for treat gastritis, stomatitis, and inflammatory diarrhea. We therefore examined the effects of HST and its active ingredients on 5-FU-induced CXCL1 upregulation in cultured colon tissue, and also examined the effects of HST on 5-FU-induced diarrhea development in the mouse...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29196676/efficiency-of-novel-nanocombinations-of-bovine-milk-proteins-lactoperoxidase-and-lactoferrin-for-combating-different-human-cancer-cell-lines
#18
Marwa M Abu-Serie, Esmail M El-Fakharany
Bovine lactoperoxidase (LPO) and lactoferrin (LF) are suitable proteins to be loaded or adsorbed to chitosan nanoparticles (NPs) for preparing stable nanoformulations with potent anticancer activity. In the present study, nanocombinations of LPO and LF revealed improvement in their stability and activity compared to single (free or nanoformulated) bovine proteins. The coating or loading of LPO-loaded NPs with LF resulted in the highest synergistic cytotoxicity effect against Caco-2, HepG-2, MCF-7 and PC-3 cells in comparison with other NPs and free proteins without causing toxicity toward normal cells...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29190948/enhanced-antitumor-efficacy-and-reduced-toxicity-of-abnormal-savda-munziq-on-tumor-bearing-mice-treated-with-chemotherapy
#19
Tao Yang, Wenhui Shi, Zukereguli Wumaierniyazi, Lianlian Shan, Weiwei Miao, Guizhen Wu, Bin Zhou, Abdryim Yusup, Halmurat Upur, Ainiwaer Aikemu
Previous research has demonstrated the anti-tumor properties of Abnormal Savda Munziq (ASMq), a traditional Uyghur compound herbal medicine. The effects of ASMq on cervical carcinomas in U27 tumor-bearing mice is investigated, the effect of adding Fluorouracil (5-FU) is also assessed in this paper. The results demonstrate that ASMq and 5-FU significantly inhibited the proliferation of U27 cells in a time-dependent and dose-dependent manner. Evaluating the interactions between ASMq and 5-FU on U27 cell growth yields a combination index (CI) < 1 in different time periods, suggesting a synergistic effect between the two drugs in vitro...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29190391/radiotherapy-for-locally-advanced-resectable-t3-t4-laryngeal-cancer-does-laryngeal-preservation-strategy-compromise-survival
#20
Hideya Yamazaki, Gen Suzuki, Satoaki Nakamura, Shigeru Hirano, Ken Yoshida, Koji Konishi, Teruki Teshima, Kazuhiko Ogawa
With the advancement of chemotherapy, a laryngeal preservation (LP) strategy was explored with the aim of improving maintenance of quality of life. Induction chemotherapy (ICT) following radiotherapy (RT) was considered a viable option because of its high initial response rate without hampering of overall survival (OS). Subsequently, concurrent chemoradiotherapy (CCRT) using CDDP became the standard of care for LP, showing the best LP ratio. For enhancing treatment intensity, ICT with taxan + CDDP + 5-FU (TPF-ICT) followed by RT showed superiority over ICT with CDDP + 5-FU (PF-ICT) followed by RT...
November 28, 2017: Journal of Radiation Research
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