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Dina S Salem, Mahmoud A Sliem, Mohamed El-Sesy, Samia A Shouman, Yehia Badr
A green method was used for producing gold nanoparticles (Au NPs) using chitosan as a natural cationic, biodegradable and biocompatible polymer. In this method, chitosan acts as a reducing and stabilizing agent for the synthesis of Au NPs. Different concentrations of chitosan solutions (0.01%, 0.05%, 0.1%, 0.2%, 0.5% and 1%) were applied. In an attempt to mitigate the side effects of anti-cancer drug, 5-fluorouracil (5-FU), through reducing drug doses in photothermal therapy, the formed positively-charged chitosan-wrapped Au NPs were used as a drug delivery system for negatively charged 5-FU to hepatocellular carcinoma cells (HepG2)...
April 4, 2018: Journal of Photochemistry and Photobiology. B, Biology
Sadamoto Zenda
Chemotherapy concurrent with radiotherapy has been widely used in clinical practice because the additional benefit on radiotherapy alone had shown. Head and neck cancer: CDDP concurrent with radiotherapy has been a standard treatment for 15years both in definitive setting and postoperative setting. Esophageal cancer: 5-FU/CDDP is the best partner for radiotherapy and appropriate radiation dose has been discussed. Anal cancer: Radical concurrent chemoradiotherapy with 5-FU and mitomycin C(MMC)remains the standard of care for squamous cell carcinoma of the anus...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Shinji Tokuyama, Mutsumi Fukunaga, Ken Konishi, Shoko Honda, Ryohei Yukimoto, Aoi Okamoto, Akina Saito, Kazuyuki Okada, Hideo Ota, Shigekazu Yokoyama, Hirofumi Miki, Kenji Kobayashi
Systemic chemotherapy based on 5-fluorouracil(5-FU)is a standard treatment for unresectable or recurrent colon cancers. Here, we report a case of hyperammonemia induced by chemotherapy using 5-FU for metastatic colon cancer. An 84-yearold male patient with past histories of liver cirrhosis related to hepatitis C virus and renal dysfunction underwent an operation for the rectosigmoid colon cancer 8 years ago. Three years after that operation, a local recurrence of the colon cancer was diagnosed, and chemotherapy using sLV5FU2 was initiated...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Junji Kawada, Masaya Nishino, Tomoki Hata, Takayuki Ogino, Masateru Okawa, Hiromitsu Hoshino, Miho Okano, Kenichi Nagai, Naruyasu Kakita, Yongkook Kim, Masaki Okuyama, Toshimasa Tsujinaka
We report a case of advanced esophageal cancer that was successfully treated using chemotherapy, operation, and chemoradiotherapy. A 66-year-old man with advanced esophageal cancer(Mt, O-Is, T4[N0.7-stomach], N2, M0, Stage III)was administered chemotherapy(docetaxel[DOC], cisplatin[CDDP], and 5-fluorouracil[5-FU]: DCF). As the esophageal tumor achieved complete clinical response after 2 courses of chemotherapy, lymph node dissection and proximal gastrectomy were performed for the residual tumor. Abdominal CT 3 months after surgery revealed lymph node swelling...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Junji Kawada, Masaya Nishino, Tomoki Hata, Takayuki Ogino, Hiromitsu Hoshino, Miho Okano, Kenichi Nagai, Yongkook Kim, Masaki Okuyama, Toshimasa Tsujinaka
Refractory ascites associated with cancerous peritonitis causes abdominal tension and reduced oral intake. Frequent ascites drainage can cause rapid worsening ofa patient's general condition. Cell-free and concentrated ascites reinfusion therapy (CART)for refractory ascites was first covered in 1981, and the general conditions ofpatients and their symptoms could be improved after undergoing CART. Herein, we report a case of effective palliative care with CART for refractory ascites associated with cancerous peritonitis...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Soichiro Sasaki, Tomohisa Baba, Hayato Muranaka, Yamato Tanabe, Chiaki Takahashi, Seiichi Matsugo, Naofumi Mukaida
Adjuvant chemotherapy is used for human breast cancer patients, even after curative surgery of primary tumor, in order to prevent tumor recurrence primarily as a form of metastasis. However, anti-cancer drugs can accelerate metastasis in several mouse metastasis models. Hence, we examined the effects of post-surgical administration with 5-fluorouracil (5-FU), doxorubicin, and cyclophosphamide, on lung metastasis process, which developed after the resection of the primary tumor arising from the orthotopic injection of a mouse triple-negative breast cancer cell line, 4T1...
April 11, 2018: Molecular Cancer Therapeutics
Tatsuya Usui, Masashi Sakurai, Koji Umata, Mohamed Elbadawy, Takashi Ohama, Hideyuki Yamawaki, Shoichi Hazama, Hiroko Takenouchi, Masao Nakajima, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano, Koichi Sato, Masahiro Kaneda, Kazuaki Sasaki
Colorectal cancer is one of the most common causes of cancer death worldwide. In patients with metastatic colorectal cancer, combination treatment with several anti-cancer drugs is employed and improves overall survival in some patients. Nevertheless, most patients with metastatic disease are not cured owing to the drug resistance. Cancer stem cells are known to regulate resistance to chemotherapy. In the previous study, we established a novel three-dimensional organoid culture model from tumor colorectal tissues of human patients using an air-liquid interface (ALI) method, which contained numerous cancer stem cells and showed resistance to 5-fluorouracil (5-FU) and Irinotecan...
April 6, 2018: International Journal of Molecular Sciences
Xing Wei, Xuejun Mo, Faliang An, Xiang Ji, Yanhua Lu
2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC) is a major active constituent of the buds of Cleistocalyx operculatus (Roxb.) Merr. et Perry (Myrtaceae), a main ingredient of herbal tea in tropical zones. DMC has been reported to significantly reverse drug resistance in BEL-7402/5-FU cells. Glutathione (GSH) and glutathione S-transferase (GST) play important roles in an efflux system that protects the cells from anticancer drugs. In this study, DMC remarkably decreased the intracellular GSH content and GST activity...
April 4, 2018: Food and Chemical Toxicology
Leili Asadi, Sakine Shirvalilou, Sepideh Khoee, Samideh Khoei
Despite the development of conventional therapies, include surgery, radiotherapy, chemotherapy and hyperthermia, the prognosis remains very poor. Recently, integration of conventional therapy and multifunctional nanoparticles have attracted a lot of attention because it produces a synergistic effect and better diagnostic and therapeutic efficiency. OBJECTIVE: This study aimed to investigate the uptake and cytotoxic effects of polycaprolactone (PCL)/chitosan (CHI)-coated superparamagnetic iron oxide nano-graphene oxide (SPION-NGO) as a carrier of 5-fluorouracil (5-Fu) and radiofrequency (RF) hyperthermia using an alternate magnetic field (AMF) with 13...
April 4, 2018: Anti-cancer Agents in Medicinal Chemistry
Weixia Ren, Tingting Wang, Xiangjun He, Qi Zhang, Jianhua Zhou, Fangfang Liu, Fangfang Gao, Yujun Zhang, Yulan Liu
It has been demonstrated that β‑arrestin2 is involved in the initiation and development of many types of cancers. However, its role in colorectal cancer (CRC) remains poorly understood. The present study investigated the role of β‑arrestin2 in CRC using CRC patient tissues as well as the LoVo and HCT116 CRC cell lines. Briefly, significantly higher expression of β‑arrestin2 was observed in CRC tissues compared with normal colon tissues. In addition, the downregulation of β‑arrestin2 reduced 5‑FU‑induced apoptosis in the LoVo cells, while the overexpression of β‑arrestin2 increased the apoptosis of HCT116 cells in vitro...
March 30, 2018: Oncology Reports
Qi Han, Rui Chen, Fangjie Wang, Sha Chen, Xiongshan Sun, Xiao Guan, Yao Yang, Bingjie Peng, Xiaodong Pan, Jinfang Li, Weijing Yi, Peng Li, Hongwei Zhang, Dongfang Feng, An Chen, Xiaohui Li, Shuhui Li, Zuoming Yin
Resistance to 5-fluorouracil (5-FU) and its induced immune suppression have prevented its extensive application in the clinical treatment of breast cancer. In this study, the combined effect of 50 Hz-EMFs and 5-FU in the treatment of breast cancer was explored. MCF-7 and MCF10A cells were pre-exposed to 50 Hz-EMFs for 0, 2, 4, 8 and 12 h and then treated with different concentrations of 5-FU for 24 h; cell viability was analyzed by MTT assay and flow cytometry. After pre-exposure to 50 Hz-EMFs for 12 h, apoptosis and cell cycle distribution in MCF-7 and MCF10A cells were detected via flow cytometry and DNA synthesis was measured by EdU incorporation assay...
2018: PloS One
Yoon Suk Jung, Dong-Hoe Koo, Jeong-Yoon Yang, Hee-Young Lee, Jung-Hwan Park, Jung Ho Park
The aim of this study was to investigate the effectiveness of treating gastric cancer by injecting a pluronic F-127 sol-gel formulation of 5-fluorouracil (5-FU) into normal tissue surrounding the tumor using a hollow microneedle. The MTS tetrazolium assay was performed to assess the cytotoxicity of 5-FU after application to gastric cancer cells at different concentrations for 1, 5 and 10 h. Gastric cancer cells were inoculated subcutaneously into 30 male nude mice (CrjBALB/c-nu/nu mice, male); the inoculated mouse were divided into three groups...
November 2018: Drug Delivery
Hande Güçlü, Zeynep Banu Doganlar, Vuslat Pelitli Gürlü, Altan Özal, Ayten Dogan, Meryem Aysenur Turhan, Oguzhan Doganlar
Combination therapies of cisplatin with 5-FU (PF) are an effective solution and have been widely used for the treatment of various categories of cancer. including anal, gastrointestinal and oral cancer, as well as head and neck tumours. The effects of combined PF treatment on vital intracellular signalling pathways in nontargeted cells remain unclear. The aim of this study is to explain the possible mechanisms by which combined PF treatment results in retinal toxicity and to investigate the effects of PF on important vital signalling pathways in ARPE 19 retinal pigmented epithelial cells...
April 2, 2018: Cutaneous and Ocular Toxicology
Shushu Wang, Yueyang Liang, Wenxiao Chang, Baoquan Hu, Yi Zhang
BACKGROUND Triple negative breast cancer (TNBC) has a more aggressive recurrence. Previous reports have demonstrated that sphingosine kinase 1 (SphK1) is a crucial regulator of breast cancer progression. However, the correlation of SphK1 with clinical prognosis has been poorly investigated. Thus, we aimed to elaborate the role of SphK1 in TNBC metastasis. MATERIAL AND METHODS We first determined the level of SphK1 in breast cancer tissue samples and breast cancer cells. Furthermore, the expression of HER2 and phosphor-SphK1 (pSphK1) in human breast cancer tissue samples was determined by immunohistochemical analysis...
April 1, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Zhonghua Wu, Dehao Yu, Shan Zhao, Peng Gao, Yongxi Song, Yu Sun, Xiaowan Chen, Zhenning Wang
BACKGROUND: Colorectal neuroendocrine carcinoma (CRNEC) is a rare type of malignancy and is quite aggressive with dismal prognosis. Neither large-scale retrospective studies nor prospective studies have been performed to evaluate the prognostic value of adjuvant chemotherapy in patients with CRNEC. METHODS: Using the Surveillance, Epidemiology, and End Results-Medicare database, 318 elderly patients who were diagnosed with high-grade colorectal neuroendocrine tumors were included...
May 2018: Journal of Surgical Research
Yuesheng Zhu, Yongdong Yi, Binglong Bai, Liyi Li, Tao You, Weijian Sun, Yaojun Yu
AIMS: Gastrointestinal cancers are a kind of deadly malignancy afflicting close to a million peoples worldwide. 5-Fluorouracil (5-Fu) is a main chemotherapeutic agent for cancer treatment. However, prolonged exposure of 5-Fu to cancer cells may cause chemoresistance and decrease the therapeutic potential of 5-Fu. MAIN METHODS: Replication protein A (RPA) is a component of the origin recognition complex. In our study, we explored the role of RPA1 in hepatocellular carcinoma cell SMMC-7721, gastric cancer cell SGC-7901 and colorectal cancer HT-29 via lentiviral particles infection...
March 27, 2018: Life Sciences
Manal M Anwar, Yasmin M Syam, Eman R Kotb, Samia A Elseginy
New hybrids of thiopyrimidine-five/six heterocyclic rings were synthesized and in vitro evaluated for their antiproliferative activity against three human cancer cell lines, namely HCT116 (human colorectal carcinoma), PC-3 (human prostate adenocarcinoma) and HepG2 (human liver carcinoma) cell lines. The most potency was elicited by the target candidates against the viability of HCT116 cell lines, higher than the positive control 5-Fluorouracil (IC50 range; 0.11-0.49 µM, IC50, 5-FU; 1.10 µM). Cell cycle analysis and apoptosis activation revealed that compound 20 induced G2/M phase arrest and apoptosis in HCT116 cells...
March 29, 2018: Mini Reviews in Medicinal Chemistry
Milad Hashemzehi, Reihane Behnam-Rassouli, Seyed Mahdi Hassanian, Maryam Moradi-Binabaj, Reyhaneh Moradi-Marjaneh, Farzad Rahmani, Hamid Fiuji, Mahdi Jamili, Mahdi Mirahmadi, Nadia Boromand, Mehran Piran, Mohieddin Jafari, Amirhossein Sahebkar, Amir Avan, Majid Khazaei
Here we explored the antitumor-activity of novel-formulated-form of curcumin (phytosomal-encapsulated-curcumin) or in combination with 5-FU in breast cancer. The antiproliferative activity was assessed in 2D and 3-dimensional cell-culture-model. The migratory-behaviors of the cells were determined by migration assay. The expression levels of CyclinD1,GSK3a/b, P-AMPK, MMP9, and E-cadherin were studied by qRT-PCR and/or Western blotting. The anti-inflammatory of nano-curcumin was assessed, while antioxidant activity was evaluated by malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and total thiols (T-SH)...
March 30, 2018: Journal of Cellular Biochemistry
K Govind Babu, Tamojit Chaudhuri, K C Lakshmaiah, Lokanatha Dasappa, Linu Abraham Jacob, M C Suresh Babu, A H Rudresha, K N Lokesh, L K Rajeev
Background: Health-related quality of life (HRQOL) is an important oncologic end point for upper gastrointestinal malignancies. Unfortunately, till date, there is no published prospective data from India, comparing the HRQOL parameters between first-line chemotherapy regimens in advanced/metastatic gastric cancer. Materials and Methods: The present study aimed to compare the HRQOL of first-line systemic chemotherapy with epirubicin, cisplatin plus 5-FU (ECF) and docetaxel, cisplatin plus 5-FU (DCF) regimens in patients with locally advanced inoperable or metastatic gastric or gastro-esophageal junction adenocarcinoma...
January 2018: South Asian Journal of Cancer
Andrey V Panchenko, Elena I Fedoros, Sergey E Pigarev, Mikhail A Maydin, Ekaterina A Gubareva, Maria N Yurova, Galina S Kireeva, Galina P Lanskikh, Margarita L Tyndyk, Vladimir N Anisimov
BP-C3 is a formulation, which comprises lignin-derived polyphenolic composition of benzenepolycarboxylic acids (BP-Cx-1) with iron complex, selenium, ascorbic acid and retinol, and possesses geroprotective activity. The present study examined the effect of BP-C3 (80 mg/kg, administered 18 times in total by gavage) on the development of haematological and intestinal manifestations of toxicity following 5-fluorouracil (5-FU; 150 mg/kg, administered once via intravenous injection) administration in outbred male Swiss-H Rappolovo (SHR) mice...
March 2018: Experimental and Therapeutic Medicine
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