Xueying Jin, Xueling Yue, Zhe Huang, Xiangkun Meng, Shengnan Xu, Yuna Wu, Ying Wan, Aiko Inoue, Megumi Narisawa, Lina Hu, Guo-Ping Shi, Hiroyuki Umegaki, Toyoaki Murohara, Yanna Lei, Masafumi Kuzuya, Xian Wu Cheng
BACKGROUND: Exposure to chronic psychological stress (CPS) is a risk factor for thrombotic cardiocerebrovascular diseases (CCVDs). The expression and activity of the cysteine cathepsin K (CTSK) are upregulated in stressed cardiovascular tissues, and we investigated whether CTSK is involved in chronic stress-related thrombosis, focusing on stress serum-induced endothelial apoptosis. METHODS AND RESULTS: Eight-week-old wild-type male mice (CTSK+/+ ) randomly divided to non-stress and 3-week restraint stress groups received a left carotid artery iron chloride3 (FeCl3 )-induced thrombosis injury for biological and morphological evaluations at specific timepoints...
May 4, 2024: Cellular and Molecular Life Sciences: CMLS