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Growth Hormone Releasing

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https://www.readbyqxmd.com/read/27932410/anthropometric-factors-have-significant-influence-on-the-outcome-of-the-ghrh-arginine-test-establishment-of-normative-data-for-an-automated-immunoassay-specifically-measuring-22kd-human-growth-hormone
#1
Timo Deutschbein, Martin Bidlingmaier, Jochen Schopohl, Christian J Strasburger, Stephan Petersenn
CONTEXT: Adult growth hormone (GH) deficiency (GHD) is diagnosed by provocative testing of GH secretion. OBJECTIVE: To improve diagnostic accuracy of GH releasing hormone (GHRH) plus arginine (GARG) testing, we evaluated the influence of age, BMI, and sex, and established normative data for an automatic immunoassay specifically measuring 22kD human GH. DESIGN/SETTING: Prospective multicenter study. PARTICIPANTS: Eighty-seven patients with hypothalamic-pituitary disease and 200 healthy controls...
December 8, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27930339/growth-hormone-releasing-hormone-receptor-antagonists-inhibit-human-gastric-cancer-through-downregulation-of-pak1-stat3-nf-%C3%AE%C2%BAb-signaling
#2
Jinfeng Gan, Xiurong Ke, Jiali Jiang, Hongmei Dong, Zhimeng Yao, Yusheng Lin, Wan Lin, Xiao Wu, Shumei Yan, Yixuan Zhuang, Wai Kit Chu, Renzhi Cai, Xianyang Zhang, Herman S Cheung, Norman L Block, Chi Pui Pang, Andrew V Schally, Hao Zhang
Gastric cancer (GC) ranks as the fourth most frequent in incidence and second in mortality among all cancers worldwide. The development of effective treatment approaches is an urgent requirement. Growth hormone-releasing hormone (GHRH) and GHRH receptor (GHRH-R) have been found to be present in a variety of tumoral tissues and cell lines. Therefore the inhibition of GHRH-R was proposed as a promising approach for the treatment of these cancers. However, little is known about GHRH-R and the relevant therapy in human GC...
December 7, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27930095/multi-omics-data-integration-and-mapping-of-altered-kinases-to-pathways-reveal-gonadotropin-hormone-signaling-in-glioblastoma
#3
Savita Jayaram, Manoj Kumar Gupta, Rajesh Raju, Poonam Gautam, Ravi Sirdeshmukh
Glioblastoma multiforme (GBM) is one of the most lethal brain tumors with an inadequately understood pathophysiology. Biomarkers that guide accurate diagnosis and treatment decisions would greatly support precision medicine for GBM. Previous studies of GBM have focused on signaling pathways such as epidermal growth factor receptor (EGFR), platelet-derived growth factor receptors (PDGFRs), notch, wnt, and others, identified with single omics technology platforms (genomics, transcriptomics, or proteomics), but not with their integrated use...
December 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27929465/using-multi-fluorinated-bile-acids-and-in-vivo-magnetic-resonance-imaging-to-measure-bile-acid-transport
#4
Jessica Felton, Kunrong Cheng, Anan Said, Aaron C Shang, Su Xu, Diana Vivian, Melissa Metry, James E Polli, Jean-Pierre Raufman
Along with their traditional role as detergents that facilitate fat absorption, emerging literature indicates that bile acids are potent signaling molecules that affect multiple organs; they modulate gut motility and hormone production, and alter vascular tone, glucose metabolism, lipid metabolism, and energy utilization. Changes in fecal bile acids may alter the gut microbiome and promote colon pathology including cholerrheic diarrhea and colon cancer. Key regulators of fecal bile acid composition are the small intestinal Apical Sodium-dependent Bile Acid Transporter (ASBT) and fibroblast growth factor-19 (FGF19)...
November 27, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27914250/chitosan-nanoparticles-as-carrier-systems-for-the-plant-growth-hormone-gibberellic-acid
#5
Anderson Espirito Santo Pereira, Paula Mayara Silva, Jhones Luis Oliveira, Halley Caixeta Oliveira, Leonardo Fernandes Fraceto
This work concerns the development of nanocarriers composed of alginate/chitosan (ALG/CS) and chitosan/tripolyphosphate (CS/TPP) for the plant growth regulator gibberellic acid (GA3). ALG/CS nanoparticles with and without GA3 presented mean size of 450±10nm, polydispersity index (PDI) of 0.3, zeta potential of -29±0.5mV, concentrations of 1.52×10(11) and 1.92×10(11) nanoparticles mL(-1), respectively, and 100% encapsulation efficiency. CS/TPP nanoparticles with and without GA3 presented mean size of 195±1nm, PDI of 0...
November 23, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27911838/antagonists-of-growth-hormone-releasing-hormone-receptor-induce-apoptosis-specifically-in-retinoblastoma-cells
#6
Wai Kit Chu, Ka Sin Law, Sun On Chan, Jason Cheuk Sing Yam, Li Jia Chen, Hao Zhang, Herman S Cheung, Norman L Block, Andrew V Schally, Chi Pui Pang
Retinoblastoma (RB) is the most common intraocular cancer in children worldwide. Current treatments mainly involve combinations of chemotherapies, cryotherapies, and laser-based therapies. Severe or late-stage disease may require enucleation or lead to fatality. Recently, RB has been shown to arise from cone precursor cells, which have high MDM2 levels to suppress p53-mediated apoptosis. This finding leads to the hypothesis that restoring apoptosis mechanisms in RBs could specifically kill the cancer cells without affecting other retinal cells...
November 23, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27911591/type-b-insulin-resistance-masquerading-as-ovarian-hyperthecosis
#7
Rebecca J Brown, Jalaja Joseph, Elaine Cochran, Cornelia Gewert, Robert Semple, Phillip Gorden
CONTEXT: Hyperinsulinemia can lead to pathologic ovarian growth and androgen production. CASE DESCRIPTION: A 29 year old woman developed an autoantibody to the insulin receptor (Type B insulin resistance), causing extreme insulin resistance and hyperinsulinemia. Testosterone levels were elevated to the adult male range. Treatment with gonadotropin releasing hormone (GnRH) analog led to normalization of testosterone, despite persistent extreme insulin resistance...
December 2, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27908212/are-crh-ngf-as-psychoneuroimmune-regulators-in-women-with-polycystic-ovary-syndrome
#8
F Z Zangeneh, M M Naghizadeh, M Bagheri, M Jafarabadi
PURPOSE: Polycystic ovary syndrome (PCOS) affects quality of life and can worsen anxiety and depression either due to the features of PCOS or due to the diagnosis of a chronic disease. Corticotrophin-releasing hormone (CRH) and nerves growth factor (NGF) are the modulator for the actions of the sympathetic nervous and immune systems. METHODS: In total, 171 women divided into two groups: study and control groups. Serum CRH, NGF, and interleukins: IL-1α. IL-1β, 17A, and TNFα were determined by ELISA Kits in both groups...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27902988/smell-and-taste-to-improve-nutrition-in-very-preterm-infants-a-randomized-controlled-pilot-trial
#9
Friederike Beker, Gillian Opie, Elizabeth Noble, Yannan Jiang, Frank H Bloomfield
BACKGROUND: The perception of smell and taste, though present early in development, is not routinely considered in the care of preterm infants. Smell and taste are known to increase gut motility, insulin secretion, and the release of appetite, digestive and metabolic hormones. OBJECTIVE: We aimed to investigate the effect of regular smell and taste on the time from birth to full enteral feeds, and the feasibility of the study protocol in very preterm infants. METHODS: In a randomized controlled trial, infants <29 weeks' postmenstrual age (PA) were assigned to receive either the smell and taste of milk before each feed or to have no exposure to the smell and taste of milk (control)...
December 1, 2016: Neonatology
https://www.readbyqxmd.com/read/27898886/effect-of-feed-restriction-and-initial-body-weight-on-growth-performance-body-composition-and-hormones-in-male-pigs-immunized-against-gonadotropin-releasing-factor
#10
K L Moore, B P Mullan, J C Kim, H G Payne, F R Dunshea
Pigs immunized against gonadotropin-releasing factor (GnRF) have increased carcass fatness compared to entire males; however, the timing of this increase in fatness after the second immunization against GnRF has not been determined. An experiment was conducted to identify and compare the growth performance, body composition, and physiological changes in immunocastrated males (IC males) at different BW and feeding levels. A total of 64 pigs were used in a 2 × 2 × 2 factorial experiment with the treatments being 1) sex (entire males or IC males), 2) initial BW (45...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27896546/jmv2894-a-novel-growth-hormone-secretagogue-accelerates-body-mass-recovery-in-an-experimental-model-of-cachexia
#11
Elena Bresciani, Laura Rizzi, Laura Molteni, Monica Ravelli, Antonella Liantonio, Khoubaib Ben Haj Salah, Jean-Alain Fehrentz, Jean Martinez, Robert J Omeljaniuk, Giuseppe Biagini, Vittorio Locatelli, Antonio Torsello
Oncologic patients subjected to chemotherapy frequently present aphagia, malnutrition, and cachexia. The purpose of this study was to investigate whether selected growth hormone secretagogues including hexarelin, JMV2894 and JMV2951 could antagonize body weight loss and wasting induced by cisplatin administration in rats. The three growth hormone secretagogues behaved as full agonists of the growth hormone secretagogues receptor both in terms of ability to stimulate calcium mobilization in Chinese hamster ovary cells and stimulation of growth hormone release in neonatal rats...
November 28, 2016: Endocrine
https://www.readbyqxmd.com/read/27895088/hormonal-alterations-in-pcos-and-its-influence-on-bone-metabolism
#12
Abhaya Krishnan, Sridhar Muthusami
According to the World Health Organization (WHO) polycystic ovary syndrome (PCOS) occurs in 4-8% of women worldwide. The prevalence of PCOS in Indian adolescents is 12.2% according to ICMR (Indian Council of Medical Research) report. National Institute of Health documented that it affects approximately 5 million women of reproductive age in the United States . Hormonal imbalance is the characteristic of many women with polycystic ovarian syndrome. The impact of various endocrine changes in PCOS women and their relevance to bone remains to be documented...
November 28, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27893850/a-convenient-in-vivo-model-using-small-interfering-rna-silencing-to-rapidly-assess-skeletal-gene-function
#13
Wen Zhang, Can Liu, Bao Hai, Guohong Du, Hong Wang, Huijie Leng, Yingsheng Xu, Chunli Song
It is difficult to study bone in vitro because it contains various cell types that engage in cross-talk. Bone biologically links various organs, and it has thus become increasingly evident that skeletal physiology must be studied in an integrative manner in an intact animal. We developed a model using local intraosseous small interfering RNA (siRNA) injection to rapidly assess the effects of a target gene on the local skeletal environment. In this model, 160-g male Sprague-Dawley rats were treated for 1-2 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27884859/isolated-gnrh-deficiency-genotypic-and-phenotypic-characteristics-of-the-genetically-heterogeneous-greek-population
#14
Maria I Stamou, Petros Varnavas, Machi Kentrou, Fotini Adamidou, Antonis Voutetakis, Jenny Jing, Lacey Plummer, Vasiliki Koika, Neoklis A Georgopoulos
OBJECTIVE: Isolated GnRH Deficiency (IGD) is a rare heritable disorder characterized by phenotypic and genetic heterogeneity. The genetic complexity of IGD has been surfaced by analyzing clinically complex cases, structural genetic variation as well as endogamous familial cases and isolated populations, revealing an enrichment for particular genes/ pathways that reflects the homogeneous genetic background of such populations. DESIGN AND METHODS: We analyzed a cohort of 81 Greek IGD patients by performing detailed phenotyping, followed by Sanger Sequencing of 14 causative IGD genes...
November 24, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27878771/growth-hormone-deficiency-and-hypopituitarism-in-adults-after-complicated-mild-traumatic-brain-injury
#15
Stefania Giuliano, Serafina Talarico, Lucia Bruno, Francesco Beniamino Nicoletti, Claudio Ceccotti, Antonino Belfiore
PURPOSE: Traumatic brain injury is considered the main cause of hypopituitarism in adults, and GH deficiency appears to be the most frequent pituitary deficit. Most of the available studies have included all degrees of severity of trauma. We aimed to assess pituitary function and GH deficiency in adult patients at different time lengths after complicated mild TBI according to Glasgow Coma Scale. We also aimed to evaluate whether mild TBI patients with GH deficiency had developed alterations in the glycolipid profile...
November 23, 2016: Endocrine
https://www.readbyqxmd.com/read/27872195/estrogen-receptors-and-signaling-in-fibroids-role-in-pathobiology-and-therapeutic-implications
#16
Mostafa A Borahay, Mehmet R Asoglu, Aymara Mas, Sarah Adam, Gokhan S Kilic, Ayman Al-Hendy
Uterine fibroids are the most common gynecologic tumors with a significant medical and financial burden. Several genetic, hormonal, and biological factors have been shown to contribute to the development and growth of fibroid tumors. Of these factors, estrogen is particularly critical since fibroids are considered estrogen dependent because no prepubertal cases have been described in the literature and tumors tend to regress after menopause. Understanding the role of estrogen in fibroids is not only important for understanding the pathobiology of fibroids but also for the development of successful therapeutics...
November 20, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27862518/an-automated-method-to-evaluate-the-enzyme-kinetics-of-%C3%AE-glucosidases
#17
Pavel Klimeš, Pavel Mazura, Dušan Turek, Břetislav Brzobohatý
Enzyme kinetic measurements are important for the characterization and engineering of biocatalysts, with applications in a wide range of research fields. The measurement of initial reaction velocity is usually slow and laborious, which motivated us to explore the possibilities for automating this process. Our model enzyme is the maize β-glucosidase Zm-p60.1. Zm-p60.1 plays a significant role in plant growth and development by regulating levels of the active plant hormone cytokinin. Zm-p60.1 belongs to a wide group of hydrolytic enzymes...
November 12, 2016: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/27856715/highlighted-topics-recovery-from-exercise-recovery-responses-of-testosterone-growth-hormone-and-igf-1-after-resistance-exercise
#18
William J Kraemer, Nicholas A Ratamess, Bradley J Nindl
The complexity of the endocrine pathways during recovery related to anabolic function belie an over simplistic approach to its study. This review is to examines the role of resistance exercise (RE) on the recovery responses of three major anabolic hormones testosterone, growth hormone(s) and insulin-like growth factor-I. Each hormone has a complexity related to differential pathways of action as well as interactions with binding proteins and receptor interactions. Testosterone is the primary anabolic hormone and its concentration changes during the recovery period depending upon the up- or down-regulation of the androgen receptor...
November 17, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27853416/neuropeptide-control-of-feeding-behavior-in-birds-and-its-difference-with-mammals
#19
REVIEW
Tetsuya Tachibana, Kazuyoshi Tsutsui
Feeding is an essential behavior for animals to sustain their lives. Over the past several decades, many neuropeptides that regulate feeding behavior have been identified in vertebrates. These neuropeptides are called "feeding regulatory neuropeptides." There have been numerous studies on the role of feeding regulatory neuropeptides in vertebrates including birds. Some feeding regulatory neuropeptides show different effects on feeding behavior between birds and other vertebrates, particularly mammals. The difference is marked with orexigenic neuropeptides...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27849327/-determination-of-subacute-and-chronic-period-sleep-quality-in-burn-patients
#20
Berrin Pazar, Emine İyigün, İsmail Şahin
BACKGROUND: The aim of this study was to determine the sleep quality of patients treated at burn center. METHODS: The present study is descriptive research conducted between January 2014 and July 2015 at a university hospital. The study included 36 patients (32 male, 4 female; mean age 26.69±9.63; range 19 to 60 years). Patient information form and Pittsburgh Sleep Quality Index (PSQI) were used to collect data. SPSS software (version 22.0; SPSS Inc., Chicago, IL, USA) was used for the analysis of the data, and statistical significance was regarded as p<0...
September 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
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