keyword
MENU ▼
Read by QxMD icon Read
search

Growth Hormone Releasing

keyword
https://www.readbyqxmd.com/read/29454125/management-of-skull-base-tumors-in-the-obstetric-population-a-case-series
#1
Blake H Priddy, Bradley A Otto, Ricardo L Carrau, Daniel M Prevedello
BACKGROUND: Neoplasms rarely present during pregnancy. However, increase in plasma volume, hormone release induced growth, and tumor hypervascularity, can cause rapid symptoms. These range from not requiring intervention to necessitating emergent operations. OBJECTIVE: We describe an algorithm for the management of symptomatic neoplasm in the obstetric population, and provide recommendations regarding surgical indications and timing. METHODS: Patients who presented to a skull base clinic from 2010-2016 at large tertiary care hospital were reviewed to identify patients who presented with a skull base tumor during pregnancy...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29447956/pubertal-chlorocholine-chloride-exposure-inhibits-testicular-testosterone-synthesis-by-down-regulating-steroidogenic-enzymes-in-adult-rats
#2
Xiaohong Hou, Dan Huang, Qinghe Meng, Qi Zhang, Lixia Jia, Siqi Wang, Zhiyuan Cheng, Shuang Wu, Lanqin Shang, Jianjun Jiang, Weidong Hao
Chlorocholine chloride (CCC) is widely used to regulate plant growth. Considerable attention has been focused on its reproductive and developmental toxicities. In order to investigate the effects of pubertal CCC exposure on testicular testosterone (T) synthesis, male SD rats were exposed to CCC by oral gavage at doses of 0, 75, 150 and 300 mg/kg bw/day from postnatal day 23 to 70. We observed that pubertal CCC exposure lowered the body weight and the mean Johnsen's score. The percentage of seminiferous tubules with deciduous spermatogenic cells was increased in the 75 and 150 mg/kg bw/day groups...
February 12, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29438534/both-in-vivo-fsh-depletion-and-follicular-exposure-to-gonadotrophin-releasing-hormone-analogues-in-vitro-are-not-effective-to-prevent-follicular-depletion-during-chemotherapy-in-mice
#3
F Horicks, G Van Den Steen, C Gervy, H J Clarke, I Demeestere
STUDY QUESTION: Does fertility preservation using gonadotrophin-releasing hormone (GnRH) analogues during chemotherapy act through a direct effect on the ovary or through inhibition of FSH secretion? SUMMARY ANSWER: The absence of FSH in vivo and the direct exposition of ovarian follicles to GnRH analogues in vitro did not prevent chemotherapy-induced ovarian damage. WHAT IS KNOWN ALREADY: The potential mechanisms of action of GnRH analogues in protecting ovaries against chemotherapy damage remain poorly understood...
February 9, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29435973/inhibition-of-experimental-small-cell-and-non-small-cell-lung-cancers-by-novel-antagonists-of-growth-hormone-releasing-hormone
#4
Haibo Wang, Xianyang Zhang, Irving Vidaurre, Renzhi Cai, Wei Sha, Andrew V Schally
We investigated the effects of novel antagonists of growth hormone releasing hormone (GHRH), MIA602 and MIA690, on three human small cell lung cancer (SCLC) lines (H446, DMS53 and H69) and two non-SCLC (NSCLC) lines (HCC827 and H460). In vitro exposure of cancer cells to these GHRH antagonists significantly inhibited cell viability, increased cell apoptosis, decrease cellular levels of cAMP and reduced cell migration. In vivo, the antagonists strongly inhibited tumor growth in xenografted nude mice models. Subcutaneous administration of MIA602 at the dose of 5μg/day for 4-8 weeks reduced the growth of HCC827, H460 and H446 tumors by 69...
February 13, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29428703/the-contribution-of-total-and-free-iodothyronines-to-welfare-maintenance-and-management-stress-coping-in-ruminants-and-equines-physiological-ranges-and-reference-values
#5
REVIEW
Adriana Ferlazzo, Cristina Cravana, Esterina Fazio, Pietro Medica
In order to acquire a pattern of thyroid involvement in welfare maintenance in Ruminants and Equines, this review summarizes data concerning the reference values of total and free iodothyronines and their modifications in physiological conditions and in different management conditions (pregnancy, lactation, weaning, growth, isolation, restraint, shearing, confinement and transportation). Thyroidal and extrathyroidal tissues efficiently respond to management practices, giving a differentiated contribution to circulating iodothyronine changes...
February 2, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29426577/common-variants-at-somatostatin-are-significantly-associated-with-hypertension-incidence-in-smoking-and-drinking-populations
#6
Hui Zhu, Lijun Zhu, Zhengmei Fang, Song Yang, Yanchun Chen, Yuelong Jin, Xianghai Zhao, Chong Shen, Yingshui Yao
Somatostatin (SST) and growth hormone-releasing hormone (GHRH) are involved in the development of hypertension. This study aimed to evaluate whether SST and GHRH contribute to genetic susceptibility to hypertension. A case-control study consisting of 2012 hypertensive patients and 2210 matched control individuals was performed, and three tagging single-nucleotide polymorphisms were genotyped. The association of these single-nucleotide polymorphisms with hypertension and ischemic stroke was further evaluated among 4098 participants in a follow-up study...
December 28, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29423542/evaluation-of-growth-hormone-response-to-ghrh-plus-arginine-test-in-children-with-idiopathic-short-stature-role-of-peak-time
#7
M Castagno, A Monzani, S Zanetta, G Genoni, E Giglione, R Ricotti, G Bona, F Prodam, S Bellone
PURPOSE: To describe the course of growth hormone response to growth hormone releasing hormone (GHRH) plus arginine provocative test in children with idiopathic short stature (ISS) and to evaluate the role of peak time. METHODS: A retrospective study was performed analyzing 344 GHRH plus arginine provocative tests performed in children and adolescents with short stature. Serum GH levels were measured at four-time points (T0', T30', T45' and T60') and GH peak was defined as the maximum value at any time point...
February 8, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29422312/altered-expression-of-anti-m%C3%A3-llerian-hormone-during-the-early-stage-of-bovine-persistent-ovarian-follicles
#8
P U Díaz, F Rey, N C Gareis, U S Notaro, V Matiller, E M Belotti, A F Stassi, N R Salvetti, H H Ortega
Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein expressed exclusively in the gonads. This hormone is an important regulator of the early growth of follicles through inhibitory effects on the recruitment of primordial follicles into the pool of growing follicles and on granulosa cell proliferation. Cystic ovarian disease (COD) is an important disorder affecting the fertility of dairy cattle. In the present study, we evaluated the expression of AMH in granulosa cells and AMH secretion into follicular fluid in pre-ovulatory follicles from control cows, animals with spontaneously arising COD and during the development of the disease, at 5, 10 and 15 days of follicular persistence...
January 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29421580/ghrelin-attenuates-ultraviolet-b-radiation-induced-impairment-in-capacities-of-epidermal-stem-cells
#9
Yue-Hui Wang, Cheng-Kuan Sun, Xiang-Lan Li, Yan Huang, Jing Sun
Persistent exposure to solar ultraviolet radiation (UVR) causes continuous damages to skin, including progressive impairment of epidermal stem cells (ESCs) capacities. Ghrelin is the only known endogenous orexigenic hormone, which has displayed its various pharmacological functions. In the current study, we found that the specific receptor of ghrelin, growth hormone secretagogue receptor (GHS-R), is expressed in ESCs. Interestingly, GHS-R expression is significantly upregulated in response to ultraviolet B (UVB) radiation...
February 5, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29412824/ghrelin-regulation-of-glucose-metabolism
#10
Anne-Laure Poher, Matthias H Tschöp, Timo D Müller
The a 28-amino acid peptide ghrelin was discovered in 1999 as a growth hormone (GH) releasing peptide. Soon after its discovery, ghrelin was found to increase body weight and adiposity by acting on the hypothalamic melanocortinergic system. Subsequently, ghrelin was found to exert a series of metabolic effects, overall testifying ghrelin a pleiotropic nature of broad pharmacological interest. Ghrelin acts through the growth hormone secretagogue-receptor (GHS-R), a seven transmembrane G protein-coupled receptor with high expression in the anterior pituitary, pancreatic islets, thyroid gland, heart and various regions of the brain...
February 2018: Peptides
https://www.readbyqxmd.com/read/29411194/sarcopenia
#11
REVIEW
Karsten Keller
Sarcopenia is a very common, but frequently overlooked and undertreated geriatric syndrome comprising pronounced muscle mass and strength/performance loss. Estimated prevalence is between 5 and 40% in the general population, accompanied by an exponential incline with increasing age. Sarcopenia is connected to atrophy and loss of muscle fibers and motor units, affecting primarily the fast-twitch muscle fibers und their motor units. Fast-twitch muscle fibers seem to be more prone to failure of function and loss over time...
February 6, 2018: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29407222/expression-of-growth-hormone-in-the-baboon-eye
#12
Diana Cristina Pérez-Ibave, Irám Pablo Rodríguez-Sánchez, María Lourdes Garza-Rodríguez, Antonio Alí Pérez-Maya, Maricela Luna, Carlos Arámburo, Andrew Tsin, George Perry, Karim Mohamed-Noriega, Jibran Mohamed-Noriega, Humberto Cavazos Adame, Jesús Mohamed Hamsho, Hugo Alberto Barrera-Saldaña
The human growth hormone (GH) locus is comprised by two GH (GH1 and GH2) genes and three chorionic somatomammotropin (CSH1, CSH2 and CSH-L) genes. While GH1 is expressed in the pituitary gland, the rest are expressed in the placenta. However, GH1 is also expressed in several extrapituitary tissues, including the eye. So to understand the role of this hormone in the eye we used the baboon (Papio hamadryas), that like humans has a multigenic GH locus; we set up to investigate the expression and regulation of GH locus in adult and fetal baboon ocular tissues...
January 30, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29396285/uterine-artery-flow-velocity-waveform-arterial-flow-indices-follicular-dynamics-and-sex-hormones-during-preovulatory-period-in-synchronized-ovulatory-cycle-of-bos-indicus-beef-cows
#13
T Moonmanee, C Navanukraw, P Yama, J Jitjumnong
A greater understanding of the uterine artery's (UtA) biology is essential to the increase in female reproductive abilities. The UtA flow velocity waveform, blood flow volume (BFV), pulsatility and resistance indices (PI and RI), blood flow velocities, dynamics of the dominant follicle (DF), and estradiol (E2) and progesterone (P4) levels in an induced ovulatory cycle were evaluated in Thai native cattle. Twenty cows were induced with synchronized ovulation through a P4-releasing device, from Day -9 to Day -4, concurrent with the administration of two doses of a gonadotropin-releasing hormone on Day -9 and Day -1, and two doses of prostaglandin F2α on Day -4 and 8 h later...
January 25, 2018: Reproductive Biology
https://www.readbyqxmd.com/read/29396042/cow-body-condition-affects-the-hormonal-release-of-ovarian-cells-and-their-responses-to-gonadotropic-and-metabolic-hormones
#14
A V Sirotkin, A V Makarevich, E Kubovicova, J Laurincik, S Alwasel, A H Harrath
The body condition score (BCS) of cows affects their reproductive efficiency, but the underlying mechanism is unclear. We examined the effect of BCS on the basic ovarian cell functions and their responses to gonadotropic and metabolic hormones. We isolated ovarian cells from cows with a tendency toward emaciation (BCS2) and those with an average body condition (BCS3), and we compared their hormonal release and responses to FSH, leptin, ghrelin, and neuropeptide Y (NPY) added at doses of 0, 1, 10, or 100 ng/mL...
January 19, 2018: Theriogenology
https://www.readbyqxmd.com/read/29392925/biological-effect-of-neoadjuvant-androgen-deprivation-therapy-assessed-on-specimens-from-radical-prostatectomy-a-systematic-review
#15
Alessandro Antonelli, Carlotta Palumbo, Alessandro Veccia, Salvatore Grisanti, Luca Triggiani, Stefania Zamboni, Maria Furlan, Claudio Simeone, Stefano Magrini, Alfredo Berruti
INTRODUCTION: Androgen-deprivation therapy (ADT) administered in neoadjuvant setting before radical prostatectomy (RP) represents an ideal in vivo human model to test the efficacy of hormonal treatments in prostate cancer (PCa). This review summarizes the findings from published studies specifically focused on the biological effects of ADT assessed on specimens from RP. The aim is to provide a base of knowledge that might be used to design future studies on neoadjuvant therapy for PCa...
February 1, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29387897/-endocrine-paraneoplastic-syndromes
#16
REVIEW
N Reisch, M Reincke
Endocrine paraneoplastic syndromes result from the production of bioactive substances from neoplastic cells, of endocrine or neuroendocrine origin. Typically these are located in the lungs, the gastrointestinal tract, pancreas, thyroid gland, adrenal medulla, skin, prostate or breast. In endocrine paraneoplastic syndromes the secretion of peptides, amines or other bioactive substances is always ectopic and not related to the anatomical source. The clinical presentation, however, is indistinguishable from a suspected eutopic endocrine tumor posing a diagnostic challenge...
January 31, 2018: Der Internist
https://www.readbyqxmd.com/read/29383334/effects-of-toremifene-a-selective-estrogen-receptor-modulator-on-spontaneous-and-stimulated-gh-secretion-igf-i-and-igf-binding-proteins-in-healthy-elderly-subjects
#17
Ferdinand Roelfsema, Rebecca J Yang, Paul Y Takahashi, Dana Erickson, Cyril Y Bowers, Johannes D Veldhuis
Context: Estrogens amplify spontaneous and stimulated growth hormone (GH) secretion, whereas they diminish GH-dependent insulin-like growth factor (IGF)-I in a dose-dependent manner. Selective estrogen receptor modulators (SERMs), including tamoxifen and toremifene, are widely adjunctively used in breast and prostate cancer. Although some endocrine effects of tamoxifen are known, few data are available for toremifene. Objective: To explore sex-dependent effects of toremifene on spontaneous 10-hour overnight GH secretion, followed by GH-releasing hormone-ghrelin stimulation...
February 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29383116/overexpression-of-hsd17b4-exerts-tumor-suppressive-function-in-adrenocortical-carcinoma-and-is-not-associated-with-hormone-excess
#18
Guanxiong Ding, Shenghua Liu, Qiang Ding, Chenchen Feng
Aim: Adrenocortical carcinoma (ACC) is characterized with excessive hormone production. We therefore investigated expression of hormone-related genes in ACC. Results: We queried status of 14 key genes directly involved in adrenal hormone production and found HSD17B4 expression was upregulated in 39% of ACC cases on top of all queried genes. Overexpression of HSD17B4 was significantly associate with a normo-hormonal phenotype. Constitutive HSD17B4 expression was higher in ACC cell line NCI-H295R than in adrenocortical small cell carcinoma cell line SW13...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29379897/effect-of-growth-hormone-on-uterine-receptivity-in-women-with-repeated-implantation-failure-in-an-oocyte-donation-program-a-randomized-controlled-trial
#19
Signe Altmäe, Raquel Mendoza-Tesarik, Carmen Mendoza, Nicolas Mendoza, Francesco Cucinelli, Jan Tesarik
Background and Objective: Administration of growth hormone (GH) during ovarian stimulation has been shown to improve success rates of in vitro fertilization. GH beneficial effect on oocyte quality is shown in several studies, but GH effect on uterine receptivity is not clear. To assess it, we studied whether GH administration can improve the chance of pregnancy and birth in women who experienced repeated implantation failure (RIF) using donated oocyte programs. Design and Study Population: A total of 105 infertile women were enrolled in the randomized controlled trial: 70 women were with a history of RIF with donated oocytes, and 35 infertile women underwent the first oocyte donation attempt...
January 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29374378/protective-effect-of-melatonin-on-cadmium-induced-changes-in-some-maturation-and-reproductive-parameters-of-female-prussian-carp-carassius-gibelio-b
#20
Ewa Drąg-Kozak, Magdalena Socha, Grzegorz Gosiewski, Ewa Łuszczek-Trojnar, Jarosław Chyb, Włodzimierz Popek
The aim of this study was to determine whether melatonin (Mel), which is a known antioxidant and free radical scavenger, could perform the role of a preventive agent against the toxic effects of cadmium (Cd2+) on mortality, fish growth, gonadosomatic index (GSI), luteinizing hormone (LH) secretion, the response to hormonal stimulation of spawning, and also tissue accumulation of Cd in Prussian carp females. These females received melatonin implants and were exposed to 0.4 or 4.0 mg/L of Cd (as CdCl2·2.5H2O) over either a 5- or 3-month period, followed by further 2 months of purification in clear water...
January 26, 2018: Environmental Science and Pollution Research International
keyword
keyword
73557
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"