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Growth Hormone Releasing

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https://www.readbyqxmd.com/read/29684629/mid-luteal-phase-gonadotropin-releasing-hormone-agonist-support-in-frozen-thawed-embryo-transfers-during-artificial-cycles-a-prospective-interventional-pilot-study
#1
Jaana Seikkula, Katja Ahinko, Päivi Polo-Kantola, Leena Anttila, Saija Hurme, Helena Tinkanen, Varpu Jokimaa
OBJECTIVE: To assess the effect of an additional single mid-luteal dose of gonadotropin-releasing hormone agonist (GnRHa) on pregnancy and perinatal outcomes in hormonally substituted frozen embryo transfer (FET) cycles. STUDY DESIGN: A prospective interventional pilot study. Women scheduled for FET were randomly selected to receive standard hormonal replacement therapy (HRT) for endometrial preparation or HRT with a single additional subcutaneous dose of 0.1mg triptorelin at the time of implantation...
April 20, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29680244/dynamical-behavior-of-somatostatin-14-and-its-cyclic-analogues-as-analyzed-in-bulk-and-on-plasmonic-silver-nanoparticles
#2
Belén Hernández, Yves-Marie Coïc, Eduardo López-Tobar, Santiago Sanchez-Cortes, Bruno Baron, Fernando Pflüger, Sergei G Kruglik, Régis Cohen, Mahmoud Ghomi
Primarily known as the inhibitor of growth hormone release, the role of somatostatin in many other inhibiting activities upon binding to its five G-protein-coupled receptors has been elucidated. Because of the short half-life of somatostatin, a number of synthetic analogues were elaborated for this peptide hormone. Herein, after recalling the main somatostatin therapeutic interests, we present the dynamical behavior of somatostatin-14 and its two currently used synthetic cyclic analogues, octreotide and pasireotide...
2018: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/29678724/thyroid-hormone-actions-on-male-reproductive-system-of-teleost-fish
#3
REVIEW
Aldo Tovo-Neto, Maira da Silva Rodrigues, Hamid R Habibi, Rafael Henrique Nóbrega
Thyroid hormones (THs) play important roles in the regulation of many biological processes of vertebrates, such as growth, metabolism, morphogenesis and reproduction. An increasing number of studies have been focused on the involvement of THs in the male reproductive system of vertebrates, in particular of fish. Therefore, this mini-review aims to summarize the main findings on THs role in male reproductive system of fish, focusing on sex differentiation, testicular development and spermatogenesis. The existing data in the literature have demonstrated that THs exert their roles at the different levels of the hypothalamic-pituitary-gonadal (HPG) axis...
April 17, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29672153/p21-activated-kinase4-in-pancreatic-acini-is-activated-by-gi-hormones-growth-factors-by-novel-signaling-and-is-needed-to-stimulate-secretory-growth-cascades
#4
Irene Ramos-Alvarez, Robert T Jensen
p21-activated kinases(PAKs) are highly conserved serine/threonine protein kinases, which are divided into two groups:Group-I(PAKs1-3) and Group-II(PAKs4-6). In various tissues, Group-II PAKs play important roles in cytoskeletal dynamics, cell growth as well as neoplastic development/progression. However, little is known about Group-II PAKs role in a number of physiological events including their ability to be activated by gastrointestinal(GI) hormones/neurotransmitters/growth-factors(GFs). We used rat pancreatic acini to explore the ability of GI-hormones/neurotransmitters/GFs to activate Group-II-PAKs and the signaling cascades involved...
April 19, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29669803/growth-hormone-in-combination-with-leuprorelin-in-pubertal-children-with-idiopathic-short-stature
#5
Imane Benabbad, Myriam Rosilio, Maithe Tauber, Emmanuel Paris, Anne Fjellestad-Paulsen, Lovisa Berggren, Hiren Patel, Jean-Claude Carel
OBJECTIVE: There is a scarcity of data from randomised controlled trials on the association of growth hormone (GH) with gonadotrophin-releasing hormone (GnRH) agonists in idiopathic short stature (ISS), although this off-label use is common. We aimed to test whether delaying pubertal progression could increase near-adult height (NAH) in GH-treated patients with ISS. METHODS: Patients with ISS at puberty onset were randomised to GH with leuprorelin (combination, n=46) or GH alone (n=45)...
April 18, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29663325/a-new-approach-to-the-treatment-of-acute-myeloid-leukaemia-targeting-the-receptor-for-growth-hormone-releasing-hormone
#6
Joaquin J Jimenez, Gina M DelCanto, Petra Popovics, Aymee Perez, Ailin Vila Granda, Irving Vidaurre, Ren-Zhi Cai, Ferenc G Rick, Ronan T Swords, Andrew V Schally
Growth hormone-releasing hormone (GHRH) is secreted by the hypothalamus and acts on the pituitary gland to stimulate the release of growth hormone (GH). GHRH can also be produced by human cancers, in which it functions as an autocrine/paracrine growth factor. We have previously shown that synthetic antagonistic analogues of GHRH are able to successfully suppress the growth of 60 different human cancer cell lines representing over 20 cancers. Nevertheless, the expression of GHRH and its receptors in leukaemias has never been examined...
April 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29624010/molecular-characterization-and-expression-patterns-of-ghrelin-in-the-reindeer-rangifer-tarandus
#7
M Zhang, X Zhu, X Xu, X Jin, H Bao, S Dugeer, C Du, G Cao, Y Yang
Ghrelin is a novel growth hormone (GH)-releasing peptide, which has been identified as an endogenous ligand for the GH-sretagogue receptor. The sequence and expression of ghrelin has been determined in many species. In this study, to reveal the molecular characterization and expression patterns of ghrelin in the reindeer (Rangifer tarandus), the full-length DNA and cDNA encoding ghrelin were cloned from reindeer stomach using genome walking and rapid amplification of complementary deoxyribonucleic acid ends (RACE)...
March 2018: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29618597/regulation-of-vascular-calcification-by-growth-hormone-releasing-hormone-and-its-agonists
#8
Jian Shen, Ning Zhang, Yi-Nuo Lin, PingPing Xiang, Xian-Bao Liu, Peng-Fei Shan, Xin-Yang Hu, Wei Zhu, Yao-Liang Tang, Keith A Webster, Ren-Zhi Cai, Andrew Schally, Jian'an Wang, Hong Yu
<u>Rationale:</u> Vascular calcification (VC) is a marker of the severity of atherosclerotic disease. Hormones play important roles in regulating calcification; estrogen and parathyroid hormones exert opposing effects, the former alleviating VC and the latter exacerbating it. So far no treatment strategies have been developed to regulate clinical VC. <u>Objective:</u> To investigate the effect of growth hormone-releasing hormone (GHRH) and its agonist (GHRH-A) on the blocking of VC in a mouse model...
April 4, 2018: Circulation Research
https://www.readbyqxmd.com/read/29616079/-stat6-pbx2-and-pbrm1-emerge-as-predicted-regulators-of-452-differentially-expressed-genes-associated-with-puberty-in-brahman-heifers
#9
Loan T Nguyen, Antonio Reverter, Angela Cánovas, Bronwyn Venus, Stephen T Anderson, Alma Islas-Trejo, Marina M Dias, Natalie F Crawford, Sigrid A Lehnert, Juan F Medrano, Milt G Thomas, Stephen S Moore, Marina R S Fortes
The liver plays a central role in metabolism and produces important hormones. Hepatic estrogen receptors and the release of insulin-like growth factor 1 (IGF1) are critical links between liver function and the reproductive system. However, the role of liver in pubertal development is not fully understood. To explore this question, we applied transcriptomic analyses to liver samples of pre- and post-pubertal Brahman heifers and identified differentially expressed (DE) genes and genes encoding transcription factors (TFs)...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29609446/near-final-height-in-korean-children-referred-for-evaluation-of-short-stature-clinical-utility-and-analytical-validity-of-height-prediction-methods
#10
Seung Woo Jeong, Ja Hyang Cho, Hae Woon Jung, Kye Shik Shim
PURPOSE: Predicted adult height (PAH) is often crucial to decision-making about treatment with human growth hormone (GH) or gonadotropin-releasing hormone agonist in children with short stature. This study compares final adult height (FAH) with different methods used to determine PAH and assesses the clinical utility and analytical validity of height prediction for children not treated with GH. METHODS: Clinical findings were retrospectively analyzed, and the heights of 44 children (22 males and 22 females) who visited our clinic between August 2006 and June 2017 and reached near final adult height (NFAH) were evaluated...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29603861/msc-cross-talk-with-cancer-cells-provides-therapeutic-potential
#11
REVIEW
Catharina Melzer, Juliane von der Ohe, Ralf Hass
Various direct and indirect cellular interactions between multi-functional mesenchymal stroma/stem-like cells (MSC) and cancer cells contribute to increasing plasticity within the tumor tissue and its microenvironment. Direct and tight communication between MSC and cancer cells is based on membrane protein interactions and the exchange of large plasma membrane fragments also known as trogocytosis. An ultimate but rare direct interaction resumes in fusion of these two cellular partners resulting in the formation of new cancer hybrid cell populations...
March 31, 2018: Stem Cells
https://www.readbyqxmd.com/read/29599723/brain-transcriptome-profiling-analysis-of-nile-tilapia-oreochromis-niloticus-under-long-term-hypersaline-stress
#12
Yan Liu, Erchao Li, Chang Xu, Yujie Su, Jian G Qin, Liqiao Chen, Xiaodan Wang
The fish brain plays an important role in controlling growth, development, reproduction, and adaptation to environmental change. However, few studies stem from the perspective of whole transcriptome change in a fish brain and its response to long-term hypersaline stress. This study compares the differential transcriptomic responses of juvenile Nile tilapia ( Oreochromis niloticus ) maintained for 8 weeks in brackish water (16 practical salinity units, psu) and in freshwater. Fish brains from each treatment were collected for RNA-seq analysis to identify potential genes and pathways responding to hypersaline stress...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29597231/physiology-of-the-calcium-parathyroid-hormone-vitamin-d-axis
#13
David Goltzman, Michael Mannstadt, Claudio Marcocci
Classic endocrine feedback loops ensure the regulation of blood calcium. Calcium in the extracellular fluid (ECF) binds and activates the calcium sensing receptor (CaSR) on the parathyroid cells, leading to an increase in intracellular calcium. This in turn leads to a reduced parathyroid hormone (PTH) release. Hypocalcemia leads to the opposite sequence of events, namely, lowered intracellular calcium and increased PTH production and secretion. PTH rapidly increases renal calcium reabsorption and, over hours to days, enhances osteoclastic bone resorption and liberates both calcium and phosphate from the skeleton...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29596439/expression-of-progenitor-markers-is-associated-with-the-functionality-of-a-bioartificial-adrenal-cortex
#14
Mariya Balyura, Evgeny Gelfgat, Charlotte Steenblock, Andreas Androutsellis-Theotokis, Gerard Ruiz-Babot, Leonardo Guasti, Martin Werdermann, Barbara Ludwig, Tobias Bornstein, Andrew V Schally, Ana Brennand, Stefan R Bornstein
Encapsulation of primary bovine adrenocortical cells in alginate is an efficacious model of a bioartificial adrenal cortex. Such a bioartificial adrenal cortex can be used for the restoration of lost adrenal function in vivo as well as for in vitro modeling of the adrenal microenvironment and for investigation of cell-cell interactions in the adrenals. The aim of this work was the optimization of a bioartificial adrenal cortex, that is the generation of a highly productive, self-regenerating, long-term functioning and immune tolerant bioartificial organ...
2018: PloS One
https://www.readbyqxmd.com/read/29594256/from-consternation-to-revelation-discovery-of-a-role-for-igsf1-in-pituitary-control-of-thyroid-function
#15
REVIEW
Daniel J Bernard, Emilie Brûlé, Courtney L Smith, Sjoerd D Joustra, Jan M Wit
Immunoglobulin superfamily, member 1 (IGSF1) is a transmembrane glycoprotein highly expressed in the mammalian pituitary gland. Shortly after its discovery in 1998, the protein was proposed to function as a coreceptor for inhibins (and was even temporarily renamed inhibin binding protein). However, subsequent investigations, both in vitro and in vivo , failed to support a role for IGSF1 in inhibin action. Research on IGSF1 nearly ground to a halt until 2011, when next-generation sequencing identified mutations in the X-linked IGSF1 gene in boys and men with congenital central hypothyroidism...
March 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29590401/noradrenergic-activity-in-the-human-brain-a-mechanism-supporting-the-defense-against-hypoglycemia
#16
Renata D Belfort-DeAguiar, Jean-Dominique Gallezot, Janice J Hwang, Ahmed Elshafie, Catherine W Yeckel, Owen Chan, Richard E Carson, Yu-Shin Ding, Robert S Sherwin
Context: Hypoglycemia, one of the major factors limiting optimal glycemic control in insulin-treated diabetic patients, elicits a brain response to restore normoglycemia by activating counterregulation. Animal data indicate that local release of norepinephrine in the hypothalamus is important for triggering hypoglycemia-induced counterregulatory (CR) hormonal responses. Objective: To examine the potential role of brain noradrenergic activation in humans during hypoglycemia...
March 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29582717/maternal-protein-malnutrition-effects-on-prostate-development-and-adult-disease
#17
J C Rinaldi, S A A Santos, K T Colombelli, L Birch, G S Prins, L A Justulin, S L Felisbino
Well-controlled intrauterine development is an essential condition for many aspects of normal adult physiology and health. This process is disrupted by poor maternal nutrition status during pregnancy. Indeed, physiological adaptations occur in the fetus to ensure nutrient supply to the most vital organs at the expense of the others, leading to irreversible consequences in tissue formation and differentiation. Evidence indicates that maternal undernutrition in early life promotes changes in key hormones, such as glucocorticoids, growth hormones, insulin-like growth factors, estrogens and androgens, during fetal development...
March 27, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29580912/usefulness-of-pharmacokinetic-efficacy-analysis-of-an-investigational-kisspeptin-analog-tak-448-in-quantitatively-evaluating-anti-tumor-growth-effect-in-the-rat-vcap-androgen-sensitive-prostate-cancer-model
#18
Kaori Ishikawa, Akira Tanaka, Akifumi Kogame, Tatsuya Watanabe, Yoshihiko Tagawa, Hisanori Matsui
TAK-448 is a kisspeptin analog with improved in vivo potency. In our previous studies in the rat JDCaP prostate cancer model, TAK-448 showed more rapid and profound reductions in plasma testosterone (T) and prostate-specific antigen (PSA, a biomarker of prostate tumor growth) levels than the gonadotropin releasing hormone (GnRH) analog leuprolide (TAP-144); however, its effects on tumor volume and subsequent tumor recurrence have not been elucidated fully. To overcome these challenges, we established the rat VCaP subcutaneous xenograft model replicating both the androgen-sensitive and castration-resistant phases of prostate cancer, and we performed pharmacokinetic/efficacy (PK/E) correlation analyses to compare the overall anti-tumor growth effects of TAK-448 to those of TAP-144...
March 23, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29577601/the-effects-of-cobalt-and-chromium-ions-on-tgf-%C3%AE-patterns-and-mineralization-in-human-osteoblast-like-mg63-and-saos-2-cells
#19
Susanne Drynda, Andreas Drynda, Bernd Feuerstein, Jörn Kekow, Christoph H Lohmann, Jessica Bertrand
Bone homeostasis, the balance of bone formation and resorption is affected by numerous influences, such as, hormones, inflammation, mechanical load, and external stimuli. The Transforming Growth Factor-beta (TGF-β), which exists in three isoforms in humans, is a major factor in the maintenance of this balance by regulating osteoblast and osteoclast maturation, development, and function. In artificial joint replacements, release of particles or ions from arthroplasties may exert local effects on the periprosthetic tissue and modulate the expression of bone specific genes and functions...
March 25, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29572446/transcriptome-profiles-reveal-the-crucial-roles-of-hormone-and-sugar-in-the-bud-dormancy-of-prunus-mume
#20
Zhiyong Zhang, XiaoKang Zhuo, Kai Zhao, Tangchun Zheng, Yu Han, Cunquan Yuan, Qixiang Zhang
Bud dormancy transition is a vital developmental process for perennial plant survival. The process is precisely regulated by diverse endogenous genetic factors and environmental cues, but the mechanisms are not yet fully understood. Prunus mume is an ideal crop for bud dormancy analysis because of its early spring-flowering characteristics and small sequenced genome. Here, we analyzed the transcriptome profiles at the three endodormancy stages and natural flush stage using RNA sequencing combined with phytohormone and sugar content measurements...
March 23, 2018: Scientific Reports
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