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https://www.readbyqxmd.com/read/29457495/effects-of-initial-body-mass-index-and-weight-change-on-all-cause-mortality-a-10-year-cohort-study-in-korea
#1
Susan Park, Sunmi Pi, Jinseub Hwang, Jae-Heon Kang, Jin-Won Kwon
We evaluated the effects of baseline body mass index (BMI) and its changes over 4 years on all-cause mortality in Korean population. We analyzed 351 735 participants whose BMI was measured in both 2002/2003 and 2006/2007. Mortality was assessed until 2013. Multivariate hazard ratios for all-cause mortality were estimated. Underweight and severe obesity with BMI >30 kg/m2 were significantly associated with higher mortality. Similarly, >5% decrease or >10% increase of BMI for 4 years was associated with the increased risk of death...
February 1, 2018: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29457329/the-companion-dog-as-a-model-for-human-aging-and-mortality
#2
Jessica M Hoffman, Kate E Creevy, Alexander Franks, Dan G O'Neill, Daniel E L Promislow
Around the world, human populations have experienced large increases in average lifespan over the last 150 years, and while individuals are living longer, they are spending more years of life with multiple chronic morbidities. Researchers have used numerous laboratory animal models to understand the biological and environmental factors that influence aging, morbidity, and longevity. However, the most commonly studied animal species, laboratory mice and rats, do not experience environmental conditions similar to those to which humans are exposed, nor do we often diagnose them with many of the naturally occurring pathologies seen in humans...
February 19, 2018: Aging Cell
https://www.readbyqxmd.com/read/29456987/effects-of-streptokinase-and-normal-saline-on-the-incidence-of-intra-abdominal-adhesion-1-week-and-1-month-after-laparotomy-in-rats
#3
Ali Hosseini, Sima Akhavan, Maziar Menshaei, Awat Feizi
Background: Intra-abdominal adhesions after surgery are usually in the form of bands and can annoy the patient throughout life causing repeated surgical procedures. Therefore, any action to prevent adhesions after surgery can increase longevity and quality of life. For this aim, this study investigates the effect of streptokinase and normal saline on the 7th day and 1 month after laparotomy. Materials and Methods: Experimental study was conducted on thirty healthy male Wistar rats weighing 200-250 g with age of 3 months divided into three groups of 10...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456543/no-interactions-of-stacked-bt-maize-with-the-non-target-aphid-rhopalosiphum-padi-and-the-spider-mite-tetranychus-urticae
#4
Yinghua Shu, Jörg Romeis, Michael Meissle
In the agroecosystem, genetically engineered plants producing insecticidal Cry proteins from Bacillus thuringiensis (Bt) interact with non-target herbivores and other elements of the food web. Stacked Bt crops expose herbivores to multiple Cry proteins simultaneously. In this study, the direct interactions between SmartStax® Bt maize producing six different Cry proteins and two herbivores with different feeding modes were investigated. Feeding on leaves of Bt maize had no effects on development time, fecundity, or longevity of the aphid Rhopalosiphum padi (Hemiptera: Aphididae), and no effects on the egg hatching time, development time, sex ratio, fecundity, and survival of the spider mite Tetranychus urticae (Acari: Tetranychidae)...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29456061/the-drosophila-cytokine-gbp-a-model-that-illuminates-the-yin-yang-of-inflammation-and-longevity-in-humans
#5
Stephen B Shears, Yoichi Hayakawa
Our laboratories have determined that the Drosophila cytokine, Growth-blocking peptide (GBP), mediates its biological effects through the Mthl10 G-protein coupled receptor. In this Cytokine Stimulus, we discuss the functional plasticity of the GBP/Mthl10 axis, and we propose that conserved components of this regulatory network may be relevant to human health.
February 15, 2018: Cytokine
https://www.readbyqxmd.com/read/29455295/is-extreme-climate-or-moderate-climate-more-conducive-to-longevity-in-china
#6
Yi Huang, Mark Rosenberg, Yingli Wang
Climate is closely related to human longevity. In China, there are many climate types. According to national population censuses from 1982 to 2000, most provinces with a high ratio of centenarians are located in western and northwestern China far from the sea; these areas are characterized by a dry, cold climate, very high altitude, very high daily temperature range, strong winds, and partial hypoxia. Meanwhile, provinces with a high ratio of nonagenarians from 1982 to 2000 are located in southern China near the sea...
February 17, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29455101/does-pedicle-screw-fixation-of-the-subaxial-cervical-spine-provide-adequate-stabilization-in-a-multilevel-vertebral-body-fracture-model-an-in-vitro-biomechanical-study
#7
John Duff, Mir M Hussain, Noelle Klocke, Jonathan A Harris, Soumya S Yandamuri, Lukas Bobinski, Roy T Daniel, Brandon S Bucklen
BACKGROUND: Cervical vertebral body fractures generally are treated through an anterior-posterior approach. Cervical pedicle screws offer an alternative to circumferential fixation. This biomechanical study quantifies whether cervical pedicle screws alone can restore the stability of a three-column vertebral body fracture, making standard 360° reconstruction unnecessary. METHODS: Range of motion (2.0 Nm) in flexion-extension, lateral bending, and axial rotation was tested on 10 cadaveric specimens (five/group) at C2-T1 with a spine kinematics simulator...
February 14, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29455009/protecting-an-adult-identity-a-grounded-theory-of-supportive-care-for-young-adults-recently-diagnosed-with-cancer
#8
Louise Soanes, Faith Gibson
BACKGROUND: For adolescents and young adults living in high-income countries cancer remains the most common disease-related death. Increasing survival rates and projected longevity are positive outcomes, although long-term consequences of cancer and/or its treatment will likely increase the global burden of cancer. In low and middle-income countries the impact and needs of young adults with cancer are largely unknown and require further attention. However, universal studies have revealed that cancer-related needs for this group are multifactorial, complex and largely unmet...
January 31, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29454226/dysphagia-and-laryngeal-pathology-in-post-surgical-cardiothoracic-patients
#9
Anna Miles, Naomi McLellan, Rochelle Machan, David Vokes, Alexandra Hunting, Mary McFarlane, Jennifer Holmes, Kelly Lynn
PURPOSE: Cardiothoracic surgery is known to result in dysphagia and laryngeal injury. While prevalence has been explored, extent, trajectory and longevity of symptoms are poorly understood. This retrospective, observational study explored dysphagia and laryngeal injury in patients following cardiothoracic surgery referred for instrumental swallowing assessment. METHODS: Clinical notes and endoscopic recordings of 106 patients (age range 18-87yrs; mean 63yrs; SD 15yrs) (including 190 endoscopes) at one large tertiary centre were reviewed by two speech-language pathologists and a laryngologist...
February 9, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29453882/early-kidney-allograft-loss-is-there-scope-for-improvement
#10
Paolo Ferrari
Increased longevity matching using Kidney Donor Profile Index (KDPI) to optimize long-term kidney allograft survival has been central to the effort of appropriate allocation of deceased donor kidneys. The data by Helenterä and co-workers in this issue, who looked at predictors of early allograft loss, should prompt an analysis of whether predictors of short-term graft survival can improve KDPI-based decisions when considering whether to accept or decline a deceased donor kidney offer. This article is protected by copyright...
February 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29453826/protein-turnover-in-aging-and-longevity
#11
REVIEW
Nathan Basisty, Jesse G Meyer, Birgit Schilling
Progressive loss of proteostasis is a hallmark of aging that is marked by declines in various components of proteostasis machinery, including: autophagy, ubiquitin-mediated degradation, protein synthesis, and others. While declines in proteostasis have historically been observed as changes in these processes, or as bulk changes in the proteome, recent advances in proteomic methodologies have enabled the comprehensive measurement of turnover directly at the level of individual proteins in vivo. These methods, which utilize a combination of stable-isotope labeling, mass spectrometry, and specialized software analysis, have now been applied to various studies of aging and longevity...
February 17, 2018: Proteomics
https://www.readbyqxmd.com/read/29453205/co-deficiency-of-lysosomal-mucolipins-3-and-1-in-cochlear-hair-cells-diminishes-outer-hair-cell-longevity-and-accelerates-age-related-hearing-loss
#12
Teerawat Wiwatpanit, Natalie N Remis, Aisha Ahmad, Yingjie Zhou, John C Clancy, Mary Ann Cheatham, Jaime García-Añoveros
Acquired hearing loss is the predominant neurodegenerative condition associated with aging in humans. Although mutations on several genes are known to cause congenital deafness in newborns, few genes have been implicated in age-related hearing loss (ARHL), perhaps because its cause is likely polygenic. Here, we generated mice lacking lysosomal calcium channel mucolipins 3 and 1 and discovered that both male and female mice suffered a polygenic form of hearing loss. While mucolipin 1 is ubiquitously expressed in all cells, mucolipin 3 is expressed in a small subset of cochlear cells -hair cells (HCs) and marginal cells of the stria vascularis- and very few other cell types...
February 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29452173/energy-intake-functions-and-energy-budgets-of-ectotherms-and-endotherms-derived-from-their-ontogenetic-growth-in-body-mass-and-timing-of-sexual-maturation
#13
Jan Werner, Nikolaos Sfakianakis, Alan D Rendall, Eva Maria Griebeler
Ectothermic and endothermic vertebrates differ not only in their source of body temperature (environment vs. metabolism), but also in growth patterns, in timing of sexual maturation within life, and energy intake functions. Here, we present a mathematical model applicable to ectothermic and endothermic vertebrates. It is designed to test whether differences in the timing of sexual maturation within an animal's life (age at which sexual maturity is reached vs. longevity) together with its ontogenetic gain in body mass (growth curve) can predict the energy intake throughout the animal's life (food intake curve) and can explain differences in energy partitioning (between growth, reproduction, heat production and maintenance, with the latter subsuming any other additional task requiring energy) between ectothermic and endothermic vertebrates...
February 13, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29452081/chronic-nosema-ceranae-infection-inflicts-comprehensive-and-persistent-immunosuppression-and-accelerated-lipid-loss-in-host-apis-mellifera-honey-bees
#14
Wenfeng Li, Yanping Chen, Steven C Cook
Nosema ceranae is an intracellular microsporidian parasite of the Asian honey bee Apis cerana and the European honey bee Apis mellifera. Until relatively recently, A. mellifera honey bees were naïve to N. ceranae infection. Symptoms of nosemosis, or Nosema disease, in the infected hosts include immunosuppression, damage to gut epithelium, nutrient and energetic stress, precocious foraging and reduced longevity of infected bees. Links remain unclear between immunosuppression, the symptoms of nutrient and energetic stress, and precocious foraging behavior of hosts...
February 13, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29451493/er%C3%AE-promotes-murine-hematopoietic-regeneration-through-the-ire1%C3%AE-mediated-unfolded-protein-response
#15
Richard H Chapple, Tianyuan Hu, Yu-Jung Tseng, Lu Liu, Ayumi Kitano, Victor Luu, Kevin A Hoegenauer, Takao Iwawaki, Qing Li, Daisuke Nakada
Activation of the unfolded protein response (UPR) sustains protein homeostasis (proteostasis) and plays a fundamental role in tissue maintenance and longevity of organisms. Long-range control of UPR activation has been demonstrated in invertebrates, but such mechanisms in mammals remain elusive. Here, we show that the female sex hormone estrogen regulates the UPR in hematopoietic stem cells (HSCs). Estrogen treatment increases the capacity of HSCs to regenerate the hematopoietic system upon transplantation and accelerates regeneration after irradiation...
February 16, 2018: ELife
https://www.readbyqxmd.com/read/29450683/common-adverse-effects-of-novel-therapies-for-multiple-myeloma-mm-and-their-management-strategies
#16
REVIEW
Kristen B McCullough, Miriam A Hobbs, Jithma P Abeykoon, Prashant Kapoor
PURPOSE OF REVIEW: The purpose of this review was to evaluate management strategies for common adverse effects of novel therapies in multiple myeloma (MM), including immunomodulatory drugs, proteasome inhibitors, monoclonal antibodies, and a histone deacetylase inhibitor. RECENT FINDINGS: There are several adverse effects that occur across multiple classes of antimyeloma drugs, including rash, peripheral neuropathy, infusion reactions, and cardiotoxicity, but most can be managed without complete discontinuation of the agent or abandonment of the class...
February 15, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29449021/effect-of-matrix-metalloproteinase-8-inhibitor-on-resin-dentin-bonds
#17
Qianmin Ou, Ya Hu, Siqi Yao, Yan Wang, Xuefeng Lin
OBJECTIVES: This study investigated the effect of matrix metalloproteinase 8 (MMP-8) on resin-dentin bonds, assessed the mechanical properties of the interfaces over time, and discussed the potential application of MMP-8 inhibitor I (MMP8-I) as a specific MMP-8 inhibitor to be incorporated into dental adhesives. METHODS: The activation and inhibition of MMP-8 was detected by colorimetric assay. After 1 day, 6 months and 1 year of storage of Control, MMP8-I, and chlorhexidine (CHX) groups, the microtensile bond strengths (μTBS) were used to evaluate the bond strength and failure mode distributions, and nanoleakage analysis was used to evaluate the minor scattered silver particles...
February 12, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29448880/migration-and-clinical-outcome-of-mobile-bearing-versus-fixed-bearing-single-radius-total-knee-arthroplasty
#18
Koen T Van Hamersveld, Perla J Marang-Van De Mheen, Huub J L Van Der Heide, Henrica M J Van Der Linden-Van Der Zwaag, Edward R Valstar, Rob G H H Nelissen
Background and purpose - Mobile-bearing total knee prostheses (TKPs) were developed in the 1970s in an attempt to increase function and improve implant longevity. However, modern fixed-bearing designs like the single-radius TKP may provide similar advantages. We compared tibial component migration measured with radiostereometric analysis (RSA) and clinical outcome of otherwise similarly designed cemented fixed-bearing and mobile-bearing single-radius TKPs. Patients and methods - RSA measurements and clinical scores were assessed in 46 randomized patients at baseline, 6 months, 1 year, and annually thereafter up to 6 years postoperatively...
February 16, 2018: Acta Orthopaedica
https://www.readbyqxmd.com/read/29447380/sirtuins-in-gamete-biology-and-reproductive-physiology-emerging-roles-and-therapeutic-potential-in-female-and-male-infertility
#19
Carla Tatone, Giovanna Di Emidio, Arcangelo Barbonetti, Gaspare Carta, Alberto M Luciano, Stefano Falone, Fernanda Amicarelli
BACKGROUND: Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases that catalyze post-translational modifications of proteins. Together, they respond to metabolic challenges, inflammatory signals or hypoxic/oxidative stress, and are associated with aging and longevity. The role of Sirtuins in the regulation of fertility emerged in 2003 when a defective reproductive phenotype was observed in SIRT1-null mice. Although studies on Sirtuins in reproductive biology have been increasing in the last years, a recent comprehensive update on this issue is still lacking...
February 13, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29447359/actn3-genotype-and-physical-function-and-frailty-in-an-elderly-chinese-population-the-rugao-longevity-and-ageing-study
#20
Teng Ma, Deyi Lu, Yin-Sheng Zhu, Xue-Feng Chu, Yong Wang, Guo-Ping Shi, Zheng-Dong Wang, Li Yu, Xiao-Yan Jiang, Xiao-Feng Wang
Objective: To examine the associations of the actinin alpha 3 gene (ACTN3) R577X polymorphism with physical performance and frailty in an older Chinese population. Methods: Data from 1,463 individuals (57.8% female) aged 70-87 years from the Rugao Longevity and Ageing Study were used. The associations between R577X and timed 5-m walk, grip strength, timed Up and Go test, and frailty index (FI) based on deficits of 23 laboratory tests (FI-Lab) were examined. Analysis of variance and linear regression models were used to evaluate the genetic effects of ACTN3 R577X on physical performance and FI-Lab...
February 13, 2018: Age and Ageing
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