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https://www.readbyqxmd.com/read/28550119/francisella-novicida-inhibits-spontaneous-apoptosis-and-extends-human-neutrophil-lifespan
#1
Lauren C Kinkead, Drew C Fayram, Lee-Ann H Allen
Francisella novicida is a Gram-negative bacterium that is closely related to the highly virulent facultative intracellular pathogen, Francisella tularensis Data published by us and others demonstrate that F. tularensis virulence correlates directly with its ability to impair constitutive apoptosis and extend human neutrophil lifespan. In contrast, F. novicida is attenuated in humans, and the mechanisms that account for this are incompletely defined. Our published data demonstrate that F. novicida binds natural IgG that is present in normal human serum, which in turn, elicits NADPH oxidase activation that does not occur in response to F...
May 26, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28549745/-anti-ageing-therapies-in-alzheimer-s-disease
#2
Gara S Alonso Abreu, José M Brito Armas, Rafael Castro Fuentes
Alzheimer's disease is the most common cause of dementia in the elderly population. Currently, there are no effective treatments to prevent or delay the natural course of the disease. Numerous studies have provided information about the molecular processes underlying biological ageing and, perhaps more importantly, potential interventions to slow ageing and promote healthy longevity in laboratory model systems. The main issue addressed in this review is whether an intervention that has anti-ageing properties can alter the appearance and/or progression of Alzheimer's disease, a disease in which age is the biggest risk factor...
May 23, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28546854/sirt1-inhibits-oxidative-stress-in-vascular-endothelial-cells
#3
REVIEW
Weijin Zhang, Qiaobing Huang, Zhenhua Zeng, Jie Wu, Yaoyuan Zhang, Zhongqing Chen
The vascular endothelium is a layer of cells lining the inner surface of vessels, serving as a barrier that mediates microenvironment homeostasis. Deterioration of either the structure or function of endothelial cells (ECs) results in a variety of cardiovascular diseases. Previous studies have shown that reactive oxygen species (ROS) is a key factor that contributes to the impairment of ECs and the subsequent endothelial dysfunction. The longevity regulator Sirt1 is a NAD(+)-dependent deacetylase that has a potential antioxidative stress activity in vascular ECs...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28546851/monoamine-oxidases-oxidative-stress-and-altered-mitochondrial-dynamics-in-cardiac-ageing
#4
REVIEW
Damien Maggiorani, Nicola Manzella, Dale E Edmondson, Andrea Mattevi, Angelo Parini, Claudia Binda, Jeanne Mialet-Perez
The advances in healthcare over the past several decades have resulted in populations now living longer. With this increase in longevity, a wider prevalence of cardiovascular diseases is more common and known to be a major factor in rising healthcare costs. A wealth of scientific evidence has implicated cell senescence as an important component in the etiology of these age-dependent pathologies. A number of studies indicate that an excess of reactive oxygen species (ROS) contributes to trigger and accelerate the cardiac senescence processes, and a new role of monoamine oxidases, MAO-A and MAO-B, is emerging in this context...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28546703/histological-surprises-in-benign-cytologies-after-lymph-node-biopsy-surgeon-s-knife-improving-patient-care
#5
Mario Victor Newton, Rakesh S Ramesh, Suraj Manjunath, K ShivaKumar, Hemanth G Nanjappa, Ramu Damuluri, Elvis Peter Joseph, C Prasad
Lymphadenopathy can be due to multitude of causes. Owing to the high prevalence of infectious diseases in India, and malignancy being a life threatening cause for lymphadenopathy; accurate diagnosis is important in preventing delay or misdiagnosis and in improving patient care, thereby increasing longevity with quality. Fine needle aspiration cytology (FNAC) is the first line investigation commonly done. Should the doctor be contented with the benign FNAC or is a lymph node biopsy needed in this age? The aims of this study are the following: (1) to study the spectral pattern of lymph node biopsies done in a surgical oncology unit of tertiary care centre, (2) to assess the yield of malignant cases from lymph node biopsy and (3) to compare the reliability of benign FNAC with lymph node biopsy...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28546605/functionality-longevity-and-aesthetics
#6
(no author information available yet)
No abstract text is available yet for this article.
May 26, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28545464/c10orf10-depp-mediated-ros-accumulation-is-a-critical-modulator-of-foxo3-induced-autophagy
#7
S Salcher, M Hermann, U Kiechl-Kohlendorfer, M J Ausserlechner, P Obexer
BACKGROUND: Neuroblastoma is the most common solid tumor in childhood and develops from undifferentiated progenitor cells of the sympathetic nervous system. In neuronal tumor cells DNA-damaging chemotherapeutic agents activate the transcription factor FOXO3 which regulates the formation of reactive oxygen species (ROS) and cell death as well as a longevity program associated with therapy resistance. We demonstrated before that C10ORF10/DEPP, a transcriptional target of FOXO3, localizes to peroxisomes and mitochondria and impairs cellular ROS detoxification...
May 25, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28544365/anti-aging-drugs-reduce-hypothalamic-inflammation-in-a-sex-specific-manner
#8
Marianna Sadagurski, Gillian Cady, Richard A Miller
Aging leads to hypothalamic inflammation, but does so more slowly in mice whose lifespan has been extended by mutations that affect GH/IGF-1 signals. Early-life exposure to GH by injection, or to nutrient restriction in the first 3 weeks of life, also modulate both lifespan and the pace of hypothalamic inflammation. Three drugs extend lifespan of UM-HET3 mice in a sex-specific way: acarbose (ACA), 17-α-estradiol (17αE2), and nordihydroguaiaretic acid (NDGA), with more dramatic longevity increases in males in each case...
May 20, 2017: Aging Cell
https://www.readbyqxmd.com/read/28543428/health-workforce-characteristics-quality-of-life-and-intention-to-leave-the-fit-for-the-future-survey-of-australian-nurses-and-midwives
#9
Lin Perry, Xiaoyue Xu, Christine Duffield, Robyn Gallagher, Rachel Nicholls, David Sibbritt
AIM: To examine the quality of life of nurses and midwives in New South Wales, Australia and compare values with those of the Australian general population; to determine the influence of workforce, health and work life characteristics on quality of life and its effect on workforce intention to leave. BACKGROUND: Few studies have examined nurses' and midwives' quality of life and little is known of its effects on workforce longevity. DESIGN: This was a cross-sectional survey conducted in 2014-2015...
May 24, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28543134/-real-life-longevity-of-implantable-cardioverter-defibrillator-devices
#10
Antonis S Manolis, Themistoklis Maounis, Spyridon Koulouris, Vassilios Vassilikos
BACKGROUND: Manufacturers of implantable cardioverter-defibrillators (ICDs) promise a 5- to 9-year projected longevity; however, real-life data indicate otherwise. The aim of the present study was to assess ICD longevity among 685 consecutive patients over the last 20 years. HYPOTHESIS: Real-life longevity of ICDs may differ from that stated by the manufacturers. METHODS: The study included 601 men and 84 women (mean age, 63.1 ± 13.3 years)...
May 22, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28542630/dose-dependent-effect-of-silver-nanoparticles-agnps-on-fertility-and-survival-of-drosophila-an-in-vivo-study
#11
Akanksha Raj, Prasanna Shah, Namita Agrawal
Silver nanoparticles (AgNPs) containing consumer products have been proliferating in the market due to its unique antimicrobial property, however, lack of in-depth knowledge about their potential effect on human health in a longer run is of great concern. Therefore, we investigated dose-dependent in vivo effect of AgNPs using Drosophila as a model system. Drosophila, a genetically tractable organism with distinct developmental stages, short life cycle and significant homology with human serves as an ideal organism to study nanomaterial-mediated toxicity...
2017: PloS One
https://www.readbyqxmd.com/read/28542504/level-of-surgical-experience-is-associated-with-change-in-hip-center-of-rotation-following-cementless-total-hip-arthroplasty-a-radiographic-assessment
#12
Seung-Chan Kim, Young-Wook Lim, Soon-Yong Kwon, Woo-Lam Jo, Sung-Hun Ju, Chan-Joo Park, Choong-Woo Lee, Yong-Sik Kim
OBJECTIVES: After total hip arthroplasty (THA), restoration of hip center of rotation (COR) is essential to ensure stability of the prosthetic hip and longevity of the prosthesis. Our aim was to determine whether, and how, the COR changed postoperatively compared to the native COR following implantation of a cementless acetabular component in anatomical position and to compare the accuracy of cup placement between two surgeons with different levels of surgical experience. MATERIALS AND METHODS: We evaluated 145 patients (145 hips) who underwent unilateral primary THA, who had no distorted acetabulum on the affected hip and a normal contralateral hip...
2017: PloS One
https://www.readbyqxmd.com/read/28541434/rapid-cold-hardening-capacity-and-its-impact-on-performance-of-russian-wheat-aphid-hemiptera-aphididae
#13
Fatemeh Saeidi, Saeid Moharramipour, Azam Mikani
The Russian wheat aphid, Diuraphis noxia (Kurdjumov), is one of the most important pests of wheat and barley in most wheat-producing countries. Rapid cold hardiness (RCH) is a capacity of insects to develop, within hours, protection against subfreezing temperatures that plays an important role in aphid survival in response to sudden decreases in air temperature. In this research, we investigated the duration and rate of cooling on the induction of RCH of D. noxia and the costs of RCH on aphid development and fecundity...
May 25, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28541063/getting-together-social-contact-frequency-across-the-life-span
#14
Julia Sander, Jürgen Schupp, David Richter
Frequent social interactions are strongly linked to positive affect, longevity, and good health. Although there has been extensive research on changes in the size of social networks over time, little attention has been given to the development of contact frequency across the life span. In this cohort-sequential longitudinal study, we examined intraindividual changes in the frequency of social contact with family and nonfamily members, and potential moderators of these changes. The data come from the 1998, 2003, 2008, and 2013 waves of the German Socio-Economic Panel (SOEP) study (N = 36,716; age range: 17-85 years)...
May 25, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28540339/leukocyte-telomere-length-and-serum-levels-of-high-molecular-weight-adiponectin-and-dehydroepiandrosterone-sulfate-could-reflect-distinct-aspects-of-longevity-in-japanese-centenarians
#15
Yuji Aoki, Masato Aoki, Kazuya Yamada
Leukocyte telomere length and serum levels of high-molecular-weight adiponectin and dehydroepiandrosterone-sulfate (DHEA-S) were assessed in association with nutrition and performance status (PS) in Japanese centenarians. Twenty-three centenarians (five men, 18 women) were classified according to their PS 1 (nearly fully ambulatory, n = 2), 2 (in bed less than 50% of daytime, n = 10), 3 (in bed greater than 50%, n = 6), and 4 (completely bedridden, n = 5). Leukocyte telomere length was determined by the hybridization protection assay, and the adiponectin and DHEA-S levels were measured by chemiluminescent enzyme immunoassay...
January 2017: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/28539178/gender-marital-status-and-longevity
#16
REVIEW
Gemma Tatangelo, Marita McCabe, Stephen Campbell, Cassandra Szoeke
Most studies report a positive relationship between marital status and health, with findings consistent across cultures and countries. Gender effects are significant, with men demonstrating greater health benefit than women. The vast majority of the research has examined heterosexual marriages, yet there has been rapid evolution in society of cohabitation patterns, who can marry, and roles in marriage. In this review, we summarise research findings and discuss important future challenges. Broader work looking at the impact of social connectedness, loneliness and support on survival should be supported...
June 2017: Maturitas
https://www.readbyqxmd.com/read/28539162/longevity-klotho-gene-polymorphism-and-the-risk-of-dementia-in-older-men
#17
Osvaldo P Almeida, Bharti Morar, Graeme J Hankey, Bu B Yeap, Jonathan Golledge, Assen Jablensky, Leon Flicker
INTRODUCTION: Klotho variants (KL-VS) have been associated with increased longevity and better cognitive function. It is unclear whether they modulate dementia risk. METHODS: We recruited 527 men aged 71-87 years who were free of cognitive impairment. We used data linkage to track the onset of dementia over 10 years. KL-VS genotyping (rs9536314 T/G) followed standard procedures. RESULTS: The annual rate of dementia was 17.2‰ (95%CI=14.0-21...
July 2017: Maturitas
https://www.readbyqxmd.com/read/28539121/network-mirroring-for-drug-repositioning
#18
Sunghong Park, Dong-Gi Lee, Hyunjung Shin
BACKGROUND: Although drug discoveries can provide meaningful insights and significant enhancements in pharmaceutical field, the longevity and cost that it takes can be extensive where the success rate is low. In order to circumvent the problem, there has been increased interest in 'Drug Repositioning' where one searches for already approved drugs that have high potential of efficacy when applied to other diseases. To increase the success rate for drug repositioning, one considers stepwise screening and experiments based on biological reactions...
May 18, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28537769/the-ksr2-rs7973260-polymorphism-is-associated-with-metabolic-phenotypes-but-not-psychological-phenotypes-in-chinese-elders
#19
Yong Wang, Teng Ma, Yin-Sheng Zhu, Xue-Feng Chu, Shun Yao, Hong-Fei Wang, Jian Cai, Xiao-Feng Wang, Xiao-Yan Jiang
OBJECTIVE: To examine the associations between genetic variants KSR2 (kinase suppressor of RAS)-rs7973260, RAPGEF6 (guanine nucleotide exchange factor 6)-rs3756290, LOC105377703-rs4481363, and subjective well-being (SWB) and depressive symptoms (DSs) in Chinese elders, which were recently associated in a genome-wide association study conducted in Caucasians. The pleiotropic effects of KSR2-rs7973260 on metabolic phenotypes were also explored. MATERIALS AND METHODS: We used data of 1788 older individuals aged 70-84 years from the aging arm of the Rugao Longevity and Aging Study, a population-based cohort study conducted in the Jiangsu province of China...
May 24, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28535283/retirement-saving-and-mental-health-in-china
#20
Dong Chen, Dennis Petrie, Kam Tang, Dongjie Wu
The Chinese population is aging rapidly while both the pension system is underdeveloped and the traditional family care arrangement is in retreat. This article's objective is to assess the relationship between concerns over retirement saving sufficiency and the mental health status of middle-aged and older Chinese adults, and identify the socioeconomic and demographic profile of those with insufficient retirement savings. A survey from about 2000 respondents collected information on self-assessed physical and mental health status based on the EQ-5D-5L framework, self-assessed longevity, retirement plans and financial preparedness and socioeconomic status...
May 23, 2017: Health Promotion International
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