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https://www.readbyqxmd.com/read/29051674/mediterranean-diet-and-prevention-of-chronic-diseases
#1
Donato F Romagnolo, Ornella I Selmin
A large body of research data suggests that traditional dietary habits and lifestyle unique to the Mediterranean region (Mediterranean diet, MD) lower the incidence of chronic diseases and improve longevity. These data contrast with troubling statistics in the United States and other high income countries pointing to an increase in the incidence of chronic diseases and the projected explosion in cost of medical care associated with an aging population. In 2013, the MD was inscribed by UNESCO in the "Representative List of the Intangible Cultural Heritage of Humanity...
September 2017: Nutrition Today
https://www.readbyqxmd.com/read/29050820/gabab-receptor-modulation-to-b-or-not-to-be-b-a-pro-cognitive-medicine
#2
REVIEW
Jordi Serrats, Mark Oliver Cunningham, Ceri Hywel Davies
Metabotropic GABAB receptors clearly modify cognitive performance in preclinical animal models, yet translation to treating human disease has been elusive. Compared to their ionotropic GABAA receptor counterpart GABAB receptors not only regulate postsynaptic excitability but also regulate diverse synaptic inputs by presynaptically inhibiting neurotransmitter release. As such, the choice of agonist, antagonist, -ve or +ve modulator as well as CNS exposure level, timing of delivery and longevity of action strongly influence the probability of unlocking the procognitive potential of GABAB receptors in human disease...
October 16, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29050686/gender-differences-in-cardiac-resynchronization-therapy-device-choice-and-outcome-in-patients-%C3%A2-75-years-of-age-with-heart-failure
#3
Yanting Wang, Michael S Sharbaugh, Mohammad Bilal Munir, Evan C Adelstein, Norman C Wang, Andrew D Althouse, Samir Saba
Cardiac resynchronization therapy (CRT) is an established therapy for heart failure and can be delivered through a CRT pacemaker (CRT-P) or a CRT defibrillator (CRT-D). CRT-P devices are smaller and less expensive, have better battery longevity, and have been subject to fewer recalls and advisories but cannot deliver high-energy shocks to terminate potentially lethal ventricular arrhythmias. As published guidelines do not distinguish between CRT-P and CRT-D indications, we examined the practice of prescribing these devices in older women and men with heart failure...
September 19, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29050682/effect-of-exceptional-parental-longevity-and-lifestyle-factors-on-prevalence-of-cardiovascular-disease-in-offspring
#4
Sriram Gubbi, Elianna Schwartz, Jill Crandall, Joe Verghese, Roee Holtzer, Gil Atzmon, Rebecca Braunstein, Nir Barzilai, Sofiya Milman
Offspring of parents with exceptional longevity (OPEL) manifest lower prevalence of cardiovascular disease (CVD), but the role of lifestyle factors in this unique cohort is not known. Our study tested whether OPEL have lesser prevalence of CVD independent of lifestyle factors. Prevalence of CVD and CVD risk factors was assessed in a population of community-dwelling Ashkenazi Jewish adults aged 65 to 94 years. Participants included OPEL (n = 395), defined as having at least 1 parent living past the age of 95 years, and offspring of parents with usual survival (OPUS, n = 450), defined as having neither parent survive to 95 years...
September 18, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29049509/prenatal-air-pollution-and-newborns-predisposition-to-accelerated-biological-aging
#5
Dries S Martens, Bianca Cox, Bram G Janssen, Diana B P Clemente, Antonio Gasparrini, Charlotte Vanpoucke, Wouter Lefebvre, Harry A Roels, Michelle Plusquin, Tim S Nawrot
Importance: Telomere length is a marker of biological aging that may provide a cellular memory of exposures to oxidative stress and inflammation. Telomere length at birth has been related to life expectancy. An association between prenatal air pollution exposure and telomere length at birth could provide new insights in the environmental influence on molecular longevity. Objective: To assess the association of prenatal exposure to particulate matter (PM) with newborn telomere length as reflected by cord blood and placental telomere length...
October 16, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29048773/use-of-a-rho-kinase-inhibitor-to-increase-human-tonsil-keratinocyte-longevity-for-three-dimensional-tissue-engineered-tonsil-epithelium-equivalents
#6
Amy K Grayson, Vanessa Hearnden, Robert Bolt, Ala Jebreel, Helen E Colley, Craig Murdoch
The generation of tissue-engineered epithelial models is often hampered by the limited proliferative capacity of primary epithelial cells. This study aimed to isolate normal tonsillar keratinocytes (NTK) from human tonsils, increase the lifespan of these cells using the Rho kinase inhibitor Y-27632 and to develop tissue-engineered equivalents of healthy and infected tonsil epithelium. The proliferation rate of isolated NTK and expression of c-MYC and p16INK4A were measured in the absence or presence of the inhibitor...
October 19, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29048268/density-separation-of-quiescent-yeast-using-iodixanol
#7
Ishtiaque Quasem, Christopher J Luby, Charles R Mace, Stephen M Fuchs
As yeast are starved of nutrients, they enter G0, a quiescent state. Quiescent yeast (Q) cells retain viability for extended periods of time and resume growth following supplementation of missing nutrients. As such, Q cells have become a valuable model for studying longevity and self-renewal of chronologically aged cells. Traditional isolation of Q cells involves a relatively long centrifugation time through a continuous density gradient. Here, we describe a rapid and cost-effective Q-cell isolation technique that uses a single-density, one-step gradient prepared from media containing iodixanol...
October 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/29048212/living-too-long-exploring-attitudes-toward-reaching-100-years-old
#8
Oscar Ribeiro, Sofia Canedo, Margarida Cerqueira, Ana Nascimento, Laetitia Teixeira
Objective This study analyses the relationship between pro- and anti-longevity attitudes, attitudes toward centenarians, and the wish to reach 100 years of age in a sample of community dwelling older adults. Methods Participants ( N = 137) completed a questionnaire on attitudes toward life-extension and an aging semantic differential using centenarians as an attitudinal target. Sociodemographic information, perceived health status, and information on knowing a centenarian were also obtained. A cluster analysis was used to identify subgroups (leaning anti-longevity group vs...
January 1, 2017: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/29045833/intestinal-fork-head-regulates-nutrient-absorption-and-promotes-longevity
#9
Ekin Bolukbasi, Mobina Khericha, Jennifer C Regan, Dobril K Ivanov, Jennifer Adcott, Miranda C Dyson, Tobias Nespital, Janet M Thornton, Nazif Alic, Linda Partridge
Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet the underlying biology remains unclear. We show that the anti-aging effects of rapamycin and reduced intestinal insulin/insulin growth factor (IGF) signaling (IIS) require the Drosophila FoxA transcription factor homolog Fork Head (FKH). Intestinal FKH induction extends lifespan, highlighting a role for the gut. FKH binds to and is phosphorylated by AKT and Target of Rapamycin. Gut-specific FKH upregulation improves gut barrier function in aged flies...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29045571/zinc-induced-metallothionein-in-centenarian-offspring-from-a-large-european-population-the-mark-age-project
#10
Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Alexander Bürkle, Maria Moreno-Villanueva, Tilman Grune, Daniela Weber, Wolfgang Stuetz, Efstathios S Gonos, Christiane Schön, Beatrix Grubeck-Loebenstein, Ewa Sikora, Olivier Toussaint, Florence Debacq-Chainiaux, Claudio Franceschi, Antti Hervonen, Eline Slagboom, Fabio Ciccarone, Michele Zampieri, Paola Caiafa, Eugène Jansen, Martijn E T Dollé, Nicolle Breusing, Eugenio Mocchegiani, Marco Malavolta
Metallothionein (MT) family are cysteine-rich proteins that regulate zinc (Zn) homeostasis and protect against oxidative damage. Studies in transgenic mice have shown that MT favourably influence longevity, although their role in human aging is not completely understood.Within the European multicenter study MARK-AGE, we analysed MT induction after Zn treatment in peripheral blood mononuclear cells (PBMCs) and its relation with redox biomarkers in 2936 age-stratified subjects (35-75 years) including the general population (RASIG), centenarian offspring (GO) and their spouses (SGO)...
October 17, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29045147/facile-fabrication-of-durable-copper-based-superhydrophobic-surfaces-via-electrodeposition
#11
Rahul Jain, Ranga Pitchumani
Superhydrophobic surfaces have myriad industrial applications, yet their practical utilization has been limited by their poor mechanical durability and longevity. We present a low cost, facile process to develop superhydrophobic copper based coatings via electrodeposition route, that addresses this limitation. Through electrodeposition, a stable, multiscale, cauliflower shaped fractal morphology was obtained and upon modification by stearic acid, the prepared coatings show extreme water repellency with contact angle of 162 ± 2(o) and roll-off angle of about 3(o)...
October 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29044222/rapid-generation-and-detection-of-biomimetic-oxygen-concentration-gradients-in-vitro
#12
Daud H Khan, Steven A Roberts, John Robert Cressman, Nitin Agrawal
Hypoxic regions exist within most solid tumors and often lead to altered cellular metabolism, metastasis, and drug resistance. Reliable generation and detection of biomimetic gaseous gradients in vitro is challenging due to low spatiotemporal resolution and poor longevity of gradients utilizing microfluidic techniques. Here, we present a novel and simplistic approach for producing gradients of dissolved oxygen (DO) within a lab-on-a-chip platform. Linear and stable DO gradients with high spatial resolution are established by introducing pre-gassed media into the gradient generating network...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044043/nutrient-availability-modulates-both-host-and-parasite-life-histories-in-a-snail-trematode-interaction
#13
Gregory J Sandland, Katherine A Josephson
Host nutrient availability can have important life history consequences for hosts and their parasites. The responses of each participant within the association can vary extensively across host-parasite systems. In this paper, we outline the life history responses of the aquatic snail Biomphalaria glabrata and its trematode parasite Echinostoma caproni during host nutrient restriction. The onset of host starvation had rapid and strong effects on snail reproduction, significantly reducing egg output in control snails and eliminating egg production in infected individuals...
October 18, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29043971/-what-are-the-treatment-needs-in-adults-an-evaluation-of-258-cases-by-the-iotn
#14
Sarah Gebeile-Chauty, William Birraux
INTRODUCTION: The aim of this epidemiological study was to evaluate the need for orthodontic treatment in a sample of adults living in France. MATERIALS AND METHODS: The indicator selected was the dental component, IOTN (index of orthodontic treatment need). RESULTS: Among the 258 adults evaluated, 37% of patients had a strong need and 21% had a moderate need; 29% of those aged 35 and under were in strong need for treatment compared with 47% of those over 35 years, with the need for treatment increasing with age...
September 2017: L' Orthodontie Française
https://www.readbyqxmd.com/read/29043775/a-double-sided-electrochromic-device-based-on-metal-organic-frameworks
#15
Issam Mjejri, Cara M Doherty, Marta Rubio-Martínez, Glenna L Drisko, Aline Rougier
Devices displaying controllably tunable optical properties through an applied voltage are attractive for smart glass, mirrors and displays. Electrochromic material development aims to decrease power consumption while increasing the variety of attainable colors, their brilliance and their longevity. We report the first electrochromic device constructed from metal organic frameworks (MOFs). Two MOF films, HKUST-1 and ZnMOF74, are assembled so that the oxidation of one corresponds to the reduction of the other, allowing the two sides of the device to simultaneously change color...
October 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29043534/male-produced-aggregation-pheromone-of-coffee-bean-weevil-araecerus-fasciculatus
#16
Shuai Yang, Xiao-Fang Zhang, Yu-Lin Gao, Dan Chen, Dong-Mei She, Tao Zhang, Jun Ning
The coffee bean weevil (CBW), Araecerus fasciculatus (De Geer, 1775), is a cosmopolitan stored-product pest, especially in tropical and subtropical areas. Previous reports showed evidence for aggregation behavior of CBW and this study aimed to identify and evaluate the aggregation pheromone of this pest. Whole-body solvent extractions were analyzed by coupled gas chromatography-mass spectrometry and comparison of male and female extracts showed a male-specific compound which was identified as squalene, 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene...
October 17, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/29043361/ion-transport-in-gel-and-gel-liquid-systems-for-liclo4-doped-pmma-at-the-meso-and-nanoscales
#17
Timothy Plett, Mya Le Thai, Josslyn Cai, Ivan Vlassiouk, Reginald M Penner, Zuzanna S Siwy
Solid and gel electrolytes offer significant advantages for cycle stability and longevity in energy storage technologies. These advantages come with trade-offs such as reduced conductivity and ion mobility, which can impact power density in storage devices even at the nanoscale. Here we propose experiments aimed at exploring the ion transport properties of a hybrid electrolyte system of liquid and gel electrolytes with meso and nanoscale components. We focus on single pore systems featuring LiClO4-propylene carbonate and LiClO4-PMMA gel, which are model electrolytes for energy storage devices...
October 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/29042724/evaluation-of-bond-strength-between-grooved-titanium-alloy-implant-abutments-and-provisional-veneering-materials-after-surface-treatment-of-the-abutments-an-in-vitro-study
#18
Gowtham Venkat, Murugesan Krishnan, Suganya Srinivasan, Muthukumar Balasubramanian
INTRODUCTION: Titanium has become the material of choice with greater applications in dental implants. The success of the dental implant does not only depend on the integration of the implant to the bone but also on the function and longevity of the superstructure. The clinical condition that demands long-term interim prosthesis is challenging owing to the decreased bond between the abutment and the veneering material. Hence, various surface treatments are done on the abutments to increase the bond strength...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29042590/effects-of-short-term-heat-shock-and-physiological-responses-to-heat-stress-in-two-bradysia-adults-bradysia-odoriphaga-and-bradysia-difformis
#19
Guodong Zhu, Ming Xue, Yin Luo, Guixia Ji, Fang Liu, Haipeng Zhao, Xia Sun
Bradysia odoriphaga and Bradysia difformis are devastating pests of vegetable, ornamental crops and edible mushrooms causing significant losses. Temperature may be an important factor restricting their population abundance in the summer. To determine the effects of short-term heat shock on adults, their survival, longevity and fecundity data were collected, and antioxidant responses and heat shock protein expression levels were examined. Our results indicated that the survival rates of Bradysia adults decreased rapidly after heat shock ≥36 °C, and the longevity and reproductive capacities were significantly inhibited, indicating that short-term heat shock had lethal and sub-lethal effects...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042144/a-comparative-surface-topographical-analysis-of-explanted-total-knee-replacement-prostheses-oxidised-zirconium-vs-cobalt-chromium-femoral-components
#20
Emma Kennard, Susan C Scholes, Raghavendra Sidaginamale, Rajkumar Gangadharan, David J Weir, James Holland, David Deehan, Thomas J Joyce
It has been proposed that an increased surface roughness of the femoral components of Total Knee Replacements (TKRs) may be a contributing factor to the accelerated wear of the polyethylene (PE) bearing and ultimately prosthesis failure. Oxidised Zirconium was introduced to the orthopaedic market in an attempt to reduce PE wear associated failures and increase the longevity of the prosthesis. In this study, non-contacting profilometry was used to measure the surface roughness of the femoral components of 6 retrieved TKRs (3 Oxidised Zirconium (OxZr) and 3 Cobalt Chromium alloy (CoCr) femoral components) and 2 as-manufactured femoral components (1 OxZr and 1 CoCr)...
October 14, 2017: Medical Engineering & Physics
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