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https://www.readbyqxmd.com/read/29679894/nicotinamide-riboside-attenuates-alcohol-induced-liver-injuries-via-activation-of-sirt1-pgc-1%C3%AE-mitochondrial-biosynthesis-pathway
#1
Sufan Wang, Ting Wan, Mingtong Ye, Yun Qiu, Lei Pei, Rui Jiang, Nengzhi Pang, Yuanling Huang, Baoxia Liang, Wenhua Ling, Xiaojun Lin, Zhenfeng Zhang, Lili Yang
BACKGROUND: Nicotinamide riboside (NR) is a nicotinamide adenine dinucleotide (NAD+ ) precursor which is present in foods such as milk and beer. It was reported that NR can prevent obesity, increase longevity, and promote liver regeneration. However, whether NR can prevent ethanol-induced liver injuries is not known. This study aimed to explore the effect of NR on ethanol induced liver injuries and the underlying mechanisms. METHODS: We fed C57BL/6 J mice with Lieber-DeCarli ethanol liquid diet with or without 400 mg/kg·bw NR for 16 days...
April 5, 2018: Redox Biology
https://www.readbyqxmd.com/read/29679428/estimating-sensitivity-of-seabed-habitats-to-disturbance-by-bottom-trawling-based-on-the-longevity-of-benthic-fauna
#2
Adriaan D Rijnsdorp, Stefan G Bolam, Clement Garcia, Jan Geert Hiddink, Niels T Hintzen, P Daniel van Denderen, Tobias van Kooten
Bottom fishing such as trawling and dredging may pose serious risks to the seabed and benthic habitats, calling for a quantitative assessment method to evaluate the impact and guide management to develop mitigation measures. We provide a method to estimate the sensitivity of benthic habitats based on the longevity composition of the invertebrate community. We hypothesize that long-lived species are more sensitive to trawling mortality due to their lower pace of life (i.e. slower growth, late maturation). We analyse data from box-core and grab samples taken from 401 stations in the English Channel and southern North Sea to estimate the habitat-specific longevity composition of the benthic invertebrate community and of specific functional groups (i...
April 20, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29679295/the-influence-of-participation-on-mortality-in-very-old-age-among-community-living-people-in-sweden
#3
Maria Haak, Charlotte Löfqvist, Susann Ullén, Vibeke Horstmann, Susanne Iwarsson
BACKGROUND: Participation in everyday life and society is generally seen as essential for health-related outcomes and acknowledged to affect older people's well-being. AIMS: To investigate if aspects of performance- and togetherness-related participation influence on mortality among very old single living people in Sweden. METHODS: ENABLE-AGE Survey Study data involving single-living participants in Sweden (N = 314, aged 81-91 years), followed over 10 years were used...
April 20, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29679203/a-window-into-extreme-longevity-the-circulating-metabolomic-signature-of-the-naked-mole-rat-a-mammal-that-shows-negligible-senescence
#4
Kaitlyn N Lewis, Nimrod D Rubinstein, Rochelle Buffenstein
Mouse-sized naked mole-rats (Heterocephalus glaber), unlike other mammals, do not conform to Gompertzian laws of age-related mortality; adults show no age-related change in mortality risk. Moreover, we observe negligible hallmarks of aging with well-maintained physiological and molecular functions, commonly altered with age in other species. We questioned whether naked mole-rats, living an order of magnitude longer than laboratory mice, exhibit different plasma metabolite profiles, which could then highlight novel mechanisms or targets involved in disease and longevity...
April 20, 2018: GeroScience
https://www.readbyqxmd.com/read/29677018/examining-the-efficacy-of-calcium-hydroxylapatite-filler-with-integral-lidocaine-in-correcting-volume-loss-of-the-jawline-a-pilot-study
#5
Margit L W Juhász, Ellen S Marmur
BACKGROUND: Patients seek 3-dimensional volume restoration of the jawline to obtain a "defined" line. Injection of filler into the jawline is not approved by the Food and Drug Administration; however, dermatologists have injected this area with positive results, minimal adverse events, and high patient satisfaction. OBJECTIVE: This study explores the efficacy of premixed calcium hydroxylapatite filler with integral lidocaine [CaHA(+)] to correct volume defects of the jawline...
April 19, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29677000/stress-resistance-and-lifespan-enhanced-by-downregulation-of-antimicrobial-peptide-genes-in-the-imd-pathway
#6
Yuh-Ru Lin, Hardik Parikh, Yongkyu Park
Biological behaviors and longevity of ectothermic animals are remarkably influenced by ambient temperature. Development at 18°C significantly enhances the stress resistance of adult flies with more accumulation of nutrients (especially fat) in the body than development at 25°C. Gene expression analysis between the flies developed at 18°C and 25°C revealed that the Immune deficiency (Imd) pathway, including the downstream antimicrobial peptides (AMPs), is downregulated in the flies developed at 18°C. When hypomorphic imd mutant flies with reduced AMP expressions were developed at 25°C, they showed induced stress resistance with higher fat content in the body similar to the wild-type flies developed at 18°C...
April 19, 2018: Aging
https://www.readbyqxmd.com/read/29676996/involvement-of-spata31-copy-number-variable-genes-in-human-lifespan
#7
Cemalettin Bekpen, Chen Xie, Almut Nebel, Diethard Tautz
The SPATA31 ( alias FAM75A) gene family belongs to the core duplicon families that are thought to have contributed significantly to hominoid evolution. It is also among the gene families with the strongest signal of positive selection in hominoids. It has acquired new protein domains in the primate lineage and a previous study has suggested that the gene family has expanded its function into UV response and DNA repair. Here we show that over-expression of SPATA31A1 in fibroblast cells leads to premature senescence due to interference with aging-related transcription pathways...
April 19, 2018: Aging
https://www.readbyqxmd.com/read/29676995/physical-decline-and-survival-in-the-elderly-are-affected-by-the-genetic-variability-of-amino-acid-transporter-genes
#8
Paolina Crocco, Eneida Hoxha, Serena Dato, Francesco De Rango, Alberto Montesanto, Giuseppina Rose, Giuseppe Passarino
Amino acid (AA) availability is a rate-limiting factor in the regulation of muscle protein metabolism and, consequently, a risk factor for age-related decline in muscle performance. AA transporters are emerging as sensors of AA availability and activators of mTORC1 signalling, acting as transceptors. Here, we evaluated the association of 58 single nucleotide polymorphisms (SNPs) in 10 selected AA transporter genes with parameters of physical performance (Hand Grip, Activity of Daily Living, Walking time). By analysing a sample of 475 subjects aged 50-89 years, we found significant associations with SLC7A5 /LAT1, SLC7A8 /LAT2, SLC36A1 /PAT1, SLC38A2 /SNAT2, SLC3A2 /CD98, SLC38A7 /SNAT7 genes...
April 18, 2018: Aging
https://www.readbyqxmd.com/read/29676634/impact-of-seasonal-winter-air-pollution-on-health-across-the-lifespan-in-mongolia-and-some-putative-solutions
#9
David Warburton, Nicole Warburton, Clarence Wigfall, Ochir Chimedsuren, Delgerzul Lodoisamba, Sereeter Lodoysamba, Badarch Jargalsaikhan
Environmental pollution of the air, water, and soil comprise an increasingly urgent challenge to global health, well-being, and productivity. The impact of environmental pollution arguably has its greatest impact across the lifespan on children, women of childbearing age, and pregnant women and their unborn children, not only because of their vulnerability during development, but also because of their subsequent longevity. Ulaanbaatar, Mongolia, is a highly instructive, perhaps extreme, example of what happens with recent, rapid urbanization...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676497/longevity-of-ceramic-onlays-a-systematic-review
#10
REVIEW
Jaafar Abduo, Raelene Jo Sambrook
OBJECTIVE: This systematic review aimed to evaluate the longevity of ceramic onlays and identify the factors that influence their survival. MATERIALS AND METHODS: An electronic search was conducted through PubMed (MEDLINE), Google Scholar and Cochrane Library, up to August 2017. The literature search aimed to retrieve all the clinical studies on the longevity of ceramic onlays. Ceramic onlay was defined as any partial ceramic restoration that covers at least one cusp...
April 20, 2018: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29675265/tissue-specific-transcriptome-profiling-of-drosophila-reveals-roles-for-gata-transcription-factors-in-longevity-by-dietary-restriction
#11
Adam J Dobson, Xiaoli He, Eric Blanc, Ekin Bolukbasi, Yodit Feseha, Mingyao Yang, Matthew D W Piper
Dietary restriction (DR) extends animal lifespan, but imposes fitness costs. This phenomenon depends on dietary essential amino acids (EAAs) and TOR signalling, which exert systemic effects. However, the roles of specific tissues and cell-autonomous transcriptional regulators in diverse aspects of the DR phenotype are unknown. Manipulating relevant transcription factors (TFs) specifically in lifespan-limiting tissues may separate the lifespan benefits of DR from the early-life fitness costs. Here, we systematically analyse transcription across organs of Drosophila subjected to DR or low TOR and predict regulatory TFs...
2018: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/29674824/effect-of-acid-etching-on-the-micro-shear-bond-strength-of-resin-composite-calcium-silicate-interface-evaluated-over-different-time-intervals-of-bond-aging
#12
Neha Sultana, Ruchika Roongta Nawal, Sarika Chaudhry, Malavika Sivakumar, Sangeeta Talwar
Introduction: With the introduction of calcium silicate materials, pulp capping procedure has been simplified due to their therapeutic pulp capping capabilities and ability to be used as a provisional bulk restorative material simultaneously. The quality of the adhesive bond between these cements and composite is of clinical significance with regard to the longevity of the final laminate restoration. Thus, this study aims to compare the in vitro microtensile bond strengths of resin composite to different calcium silicate cements versus glass ionomer cement (GIC)...
March 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29672532/the-effects-of-increasing-longevity-and-changing-incidence-on-lifetime-risk-differentials-a-decomposition-approach
#13
Marcus Ebeling, Karin Modig, Anders Ahlbom, Roland Rau
Increasing longevity can distort time trends in summary measures of health and mortality, such as the lifetime risk of getting diseased. If not observing a cohort, this lifetime risk is calculated with cross-sectional data on age-specific incidence and survival. In those instances, incidence and survival may work in opposite directions resulting in lifetime risk estimates where, reductions in incidence might be offset by a simultaneous longevity increase. The proposed method decomposes the difference between two lifetime risks into contributions of changing incidence and changing survival...
2018: PloS One
https://www.readbyqxmd.com/read/29671950/comparative-transcriptomics-across-14-drosophila-species-reveals-signatures-of-longevity
#14
Siming Ma, Andrei S Avanesov, Emily Porter, Byung Cheon Lee, Marco Mariotti, Nadezhda Zemskaya, Roderic Guigo, Alexey A Moskalev, Vadim N Gladyshev
Lifespan varies dramatically among species, but the biological basis is not well understood. Previous studies in model organisms revealed the importance of nutrient sensing, mTOR, NAD/sirtuins, and insulin/IGF1 signaling in lifespan control. By studying life-history traits and transcriptomes of 14 Drosophila species differing more than sixfold in lifespan, we explored expression divergence and identified genes and processes that correlate with longevity. These longevity signatures suggested that longer-lived flies upregulate fatty acid metabolism, downregulate neuronal system development and activin signaling, and alter dynamics of RNA splicing...
April 19, 2018: Aging Cell
https://www.readbyqxmd.com/read/29670721/the-importance-of-correct-implants-positioning-and-masticatory-load-direction-on-a-fixed-prosthesis
#15
João-Paulo-Mendes Tribst, Vinicius-Aneas Rodrigues, Amanda-Maria-de Oliveira Dal Piva, Alexandre-Luiz-Souto Borges, Renato-Sussumu Nishioka
Background: Through the biomechanical study of dental implants, it is possible to understand the dissipation effects of masticatory loads in different situations and prevent the longevity of osseointegration. Aims: To evaluate the microstrains generated around external hexagon implants, using axial and non-axial loads in a fixed four-element prosthesis with straight implants and implants inclined at 17°. Material and Methods: Three implants were modeled using CAD software following the manufacturer's measurements...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29670680/gengnianchun-extends-the-lifespan-of-caenorhabditis-elegans-via-the-insulin-igf-1-signalling-pathway
#16
Fanhui Meng, Jun Li, Yanqiu Rao, Wenjun Wang, Yan Fu
Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against A β -induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis elegans . However, the mechanism underlying this effect was unclear. In this study, we further explored the mechanisms of GNC using a C. elegans model. GNC significantly increased the lifespan of C. elegans and enhanced oxidative and thermal stress resistance...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29669100/the-impact-of-changes-in-population-health-and-mortality-on-future-prevalence-of-alzheimer-s-disease-and-other-dementias-in-the-united-states
#17
Julie M Zissimopoulos, Bryan C Tysinger, Patricia A St Clair, Eileen M Crimmins
Objectives: We assessed potential benefits for older Americans of reducing risk factors associated with dementia. Methods: A dynamic simulation model tracked a national cohort of persons 51 and 52 years of age to project dementia onset and mortality in risk reduction scenarios for diabetes, hypertension, and dementia. Results: We found reducing incidence of diabetes by 50% did not reduce number of years a person ages 51 or 52 lived with dementia and increased the population ages 65 and older in 2040 with dementia by about 115,000...
April 16, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29668591/prevalence-and-correlates-of-chronic-kidney-disease-ckd-among-art-naive-hiv-patients-in-the-niger-delta-region-of-nigeria
#18
Udeme E Ekrikpo, Andre P Kengne, Effiong E Akpan, Emmanuel E Effa, Aminu K Bello, John U Ekott, Cindy George, Babatunde L Salako, Ikechi G Okpechi
Widespread use of antiretroviral therapy (ART) in human immunodeficiency virus (HIV) patients has led to improved longevity with the attendant increase in noncommunicable disease prevalence including chronic kidney disease (CKD). This study documents the prevalence of CKD in a large HIV population in Southern Nigeria.This is a single center, 15-year analysis in ART-naïve patients. CKD was defined as the occurrence of estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m on 2 consecutive occasions 3 to 12 months apart using the chronic kidney disease epidemiology collaboration (CKD-EPI) equation...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29667524/optimization-of-the-extraction-of-bioactive-molecules-from-lycium-barbarum-fruits-and-evaluation-of-the-antioxidant-activity-a-combined-study
#19
Chiara Povolo, Alberto Foschini, Giovanni Ribaudo
Novel food, super food, wolfberry, the Himalayan longevity fruit. Several different and, even more, colourful names define the fruits of Lycium barbarum L., one of the most popular food supplements and anti-aging remedies of the recent years. Goji derivatives find application at the interface between food and medicine thanks to the claimed antioxidant and immunomodulatory properties. Aiming at identifying the most effective extraction protocol for processing different goji berries samples (fresh and dried, commercial and from an Italian cultivar), combinations of extractive and analytical techniques were attempted...
April 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29666616/stem-cell-transcription-factor-foxo-controls-microbiome-resilience-in-hydra
#20
Benedikt M Mortzfeld, Jan Taubenheim, Sebastian Fraune, Alexander V Klimovich, Thomas C G Bosch
The aging process is considered to be the result of accumulating cellular deterioration in an individual organism over time. It can be affected by the combined influence of genetic, epigenetic, and environmental factors including life-style-associated events. In the non-senescent freshwater polyp Hydra , one of the classical model systems for evolutionary developmental biology and regeneration, transcription factor FoxO modulates both stem cell proliferation and innate immunity. This provides strong support for the role of FoxO as a critical rate-of-aging regulator...
2018: Frontiers in Microbiology
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