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Longevity

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https://www.readbyqxmd.com/read/28728083/sleep-disturbances-and-risk-of-falls-in-an-old-chinese-population-rugao-longevity-and-ageing-study
#1
Teng Ma, Guoping Shi, Yinsheng Zhu, Yong Wang, Xuefeng Chu, Xiaoyan Jiang, Zuyun Liu, Jian Cai, Hongfei Wang, Li Jin, Zhendong Wang, Xiaofeng Wang
BACKGROUND: To explore the relationship between sleep disturbances and falls in an elderly Chinese population. METHODS: Data from 1726 individuals aged 70-87 years from the Rugao Longevity and Ageing Study were used. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep variables. Outcomes were falls ≥1 time per year and falls ≥2 times per year. RESULTS: A total of 22.7% of the participants experienced ≥1 fall, and 9.8% experienced ≥2 falls per year...
July 12, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28727796/effects-of-health-risk-assessment-and-counselling-on-physical-activity-in-older-people-a-pragmatic-randomised-trial
#2
Anna Marie Herghelegiu, André Moser, Gabriel Ioan Prada, Stephan Born, Matthias Wilhelm, Andreas E Stuck
BACKGROUND: Interventions to increase physical activity (PA) among older community-dwelling adults may be enhanced by using multidimensional health risk assessment (HRA) as a basis for PA counselling. METHODS: The study was conducted among nondisabled but mostly frail persons 65 years of age and older at an ambulatory geriatric clinic in Bucharest, Romania. From May to July 2014, 200 participants were randomly allocated to intervention and control groups. Intervention group participants completed an initial HRA questionnaire and then had monthly counselling sessions with a geriatrician over a period of six months that were aimed at increasing low or maintaining higher PA...
2017: PloS One
https://www.readbyqxmd.com/read/28727758/longevity-effect-of-a-polysaccharide-from-chlorophytum-borivilianum-on-caenorhabditis-elegans-and-saccharomyces-cerevisiae
#3
Steve Thomas Pannakal, Sibylle Jäger, Albert Duranton, Amit Tewari, Subarna Saha, Aneesha Radhakrishnan, Nita Roy, Jean François Kuntz, Soraya Fermas, Darryl James, Jane Mellor, Namita Misra, Lionel Breton
The traditional Indian medicine, Ayurveda, provides insights and practical solutions towards a healthy life style. Rasayana is a branch of Ayurveda known for preserving and promoting health, enhancing the quality of life and delaying the aging process. In the traditional knowledge, the Rasayana herb, Chlorophytum borivilianum (C. borivilanum) is regarded as a general health promoting tonic that delays aging and increases lifespan, cognitive function and physical strength. Aging is a complex and multifactorial physiological phenomenon that manifests itself over a wide range of biological systems, tissues, and functions...
2017: PloS One
https://www.readbyqxmd.com/read/28727346/-doctor-physical-activity-at-my-age
#4
Martial Coutaz
Engaging in regular and appropriate physical activity confers health benefits at any age. For seniors, swapping the role of « sedentary » for « someone who's on the move » offers much more substantial benefits than any medication, and notably even starting at a dose of 10-15 minutes per day ! Any physician who cares for elderly patients must pursue the objective of encouraging physical activity that is integrated into daily life (e.g. walking, gardening, shopping). This article consists of a literature review concerning the evidence for the benefits of physical activity in seniors in terms of quality of life, longevity, maintenance of functional independence, and prevention of cognitive decline...
April 19, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28727105/analysis-of-the-gut-bacterial-communities-in-beef-cattle-and-their-association-with-feed-intake-growth-and-efficiency
#5
P R Myer, H C Freetly, J E Wells, T P L Smith, L A Kuehn
The impetus behind the global food security challenge is direct, with the necessity to feed almost 10 billion people by 2050. Developing a food-secure world, where people have access to a safe and sustainable food supply, is the principal goal of this challenge. To achieve this end, beef production enterprises must develop methods to produce more pounds of animal protein with less. Selection for feed-efficient beef cattle using genetic improvement technologies has helped to understand and improve the stayability and longevity of such traits within the herd...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28725900/luminescence-properties-and-warm-white-led-application-of-a-ternary-alkaline-fluoride-red-phosphor-k2naalf6-mn-4-%C3%A2
#6
L Y Wang, E H Song, T T Deng, Y Y Zhou, Z F Liao, W R Zhao, B Zhou, Q Y Zhang
Herein, a Mn(4+) ion doped complex ternary-alkaline fluoride red phosphor K2NaAlF6:Mn(4+) has been synthesized through a facile two-step co-precipitation method at room temperature. The crystal structure, morphological properties and influence of the dopant concentration, temperature and humidity on luminescence properties as well as the performance of the as-synthesized phosphor used in white light emitting diodes (WLEDs) were investigated carefully. Intense absorption in the blue region (∼460 nm) and bright narrow-band red emission (∼630 nm) with high color purity were observed from this resultant powder...
July 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28724922/hd-66051-an-eclipsing-binary-hosting-a-highly-peculiar-hgmn-related-star
#7
Ewa Niemczura, Stefan Hümmerich, Fiorella Castelli, Ernst Paunzen, Klaus Bernhard, Franz-Josef Hambsch, Krzysztof Hełminiak
HD 66051 is an eclipsing system with an orbital period of about 4.75 d that exhibits out-of-eclipse variability with the same period. New multicolour photometric observations confirm the longevity of the secondary variations, which we interpret as a signature of surface inhomogeneities on one of the components. Using archival and newly acquired high-resolution spectra, we have performed a detailed abundance analysis. The primary component is a slowly rotating late B-type star (T eff = 12500 ± 200 K; log g = 4...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28722347/foxo3-longevity-interactome-on-chromosome-6
#8
Timothy A Donlon, Brian J Morris, Randi Chen, Kamal H Masaki, Richard C Allsopp, D Craig Willcox, Ayako Elliott, Bradley J Willcox
FOXO3 has been implicated in longevity in multiple populations. By DNA sequencing in long-lived individuals, we identified all single nucleotide polymorphisms (SNPs) in FOXO3 and showed 41 were associated with longevity. Thirteen of these had predicted alterations in transcription factor binding sites. Those SNPs appeared to be in physical contact, via RNA polymerase II binding chromatin looping, with sites in the FOXO3 promoter, and likely function together as a cis-regulatory unit. The SNPs exhibited a high degree of LD in the Asian population, in which they define a specific longevity haplotype that is relatively common...
July 19, 2017: Aging Cell
https://www.readbyqxmd.com/read/28721126/the-thyroid-gland-in-postmenopausal-women-physiology-and-diseases
#9
REVIEW
Małgorzata Gietka-Czernel
The incidence of most thyroid diseases: hypothyroidism, nodular goitre, and cancer is highest among postmenopausal and elderly women. The diagnosis of thyroid dysfunction in this group of patients is difficult because the symptoms can be nonspecific or common with menopausal and ageing complaints. In the interpretation of thyroid function tests the physiological changes in secretion and metabolism of thyrotropin (TSH) and thyroid hormones must be considered, as well as the influence of comorbidities. Unrecognised thyroid dysfunction leads to increased: cardiovascular risk, bone fractures, cognitive impairment, depression, and mortality...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28719283/american-aedes-vexans-mosquitoes-are-competent-vectors-of-zika-virus
#10
Alex Gendernalik, James Weger-Lucarelli, Selene M Garcia Luna, Joseph R Fauver, Claudia Rückert, Reyes A Murrieta, Nicholas Bergren, Demitrios Samaras, Chilinh Nguyen, Rebekah C Kading, Gregory D Ebel
AbstractStarting in 2013-2014, the Americas have experienced a massive outbreak of Zika virus (ZIKV) which has now reached at least 49 countries. Although most cases have occurred in South America and the Caribbean, imported and autochthonous cases have occurred in the United States. Aedes aegypti and Aedes albopictus mosquitoes are known vectors of ZIKV. Little is known about the potential for temperate Aedes mosquitoes to transmit ZIKV. Aedes vexans has a worldwide distribution, is highly abundant in particular localities, aggressively bites humans, and is a competent vector of several arboviruses...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28718514/aldehyde-dehydrogenase-1-a1-regulates-energy-metabolism-in-adipocytes-from-different-species
#11
Kefeng Yang, Christopher Adin, Qiwen Shen, Ly James Lee, Lianbo Yu, Paolo Fadda, Arpad Samogyi, Kathleen Ham, Lu Xu, Chen Gilor, Ouliana Ziouzenkova
BACKGROUND: Survival and longevity of xenotransplants depend on immune function and ability to integrate energy metabolism between cells from different species. However, mechanisms for interspecies cross talk in energy metabolism are not well understood. White adipose tissue stores energy and is capable of mobilization and dissipation of energy as heat (thermogenesis) by adipocytes expressing uncoupling protein 1 (Ucp1). Both pathways are under the control of vitamin A metabolizing enzymes...
July 17, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28718225/proteostasis-and-ageing-insights-from-long-lived-mutant-mice
#12
William A Sands, Melissa M Page, Colin Selman
The global increase in life expectancy is creating significant medical, social and economic challenges to current and future generations. Consequently, there is a need to identify the fundamental mechanisms underlying the ageing process. This knowledge should help develop realistic interventions capable of combatting age-related disease, and thus improving late-life health and vitality. While several mechanisms have been proposed as conserved lifespan determinants, the loss of proteostasis- where proteostasis is defined here as the maintenance of the proteome- appears highly relevant to both ageing and disease...
July 17, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28717644/optimization-of-a-functionally-graded-material-stem-in-the-femoral-component-of-a-cemented-hip-arthroplasty-influence-of-dimensionality-of-fgm
#13
Abdellah Ait Moussa, Rohan Yadav
The longevity of hip prostheses is contingent on the stability of the implant within the cavity of the femur bone. The cemented fixation was mostly adopted owing to offering the immediate stability from cement-stem and cement-bone bonding interfaces after implant surgery. Yet cement damage and stress shielding of the bone were proven to adversely affect the lifelong stability of the implant, especially among younger subjects who tend to have an active lifestyle. The geometry and material distribution of the implant can be optimized more efficiently with a three-dimensional realistic design of a functionally graded material (FGM)...
2017: Journal of Medical Engineering
https://www.readbyqxmd.com/read/28717408/sirt3-enhances-mesenchymal-stem-cell-longevity-and-differentiation
#14
Ryan A Denu
Mesenchymal stem cells (MSCs) are multipotent cells that are currently being investigated in a wide variety of clinical trials for their anti-inflammatory and immunomodulatory properties as well as their osteogenic and chondrogenic capabilities. However, there are considerable interdonor variability and heterogeneity of MSC populations, making it challenging to compare different products. Furthermore, proliferation, differentiation, and immunomodulation of MSCs decrease with aging and ex vivo expansion. The sirtuins have emerged as a class of protein deacylases involved in aging, oxidative stress, and metabolism...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28714880/upregulation-of-phosphatidylinositol-3-kinase-pi3k-enhances-ethylene-biosynthesis-and-accelerates-flower-senescence-in-transgenic-nicotiana-tabacum-l
#15
Mohd Sabri Pak Dek, Priya Padmanabhan, Sherif Sherif, Jayasankar Subramanian, And Gopinadhan Paliyath
Phosphatidylinositol 3-kinase (PI3K) is a key enzyme that phosphorylates phosphatidylinositol at 3'-hydroxyl position of the inositol head group initiating the generation of several phosphorylated phosphatidylinositols, collectively referred to as phosphoinositides. The function of PI3K in plant senescence and ethylene signal transduction process was studied by expression of Solanum lycopersicum PI3K in transgenic Nicotiana tabacum, and delineating its effect on flower senescence. Detached flowers of transgenic tobacco plants with overexpressed Sl-PI3K (OX) displayed accelerated senescence and reduced longevity, when compared to the flowers of wild type plants...
July 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28714795/analysis-of-physical-activity-among-free-living-nonagenarians-from-a-sardinian-longevous-population
#16
Giovanni Mario Pes, Maria Pina Dore, Alessandra Errigo, Michel Poulain
Physical activity was identified as a major determinant of longevity. Using wearable accelerometers, we evaluated energy expenditure (EE), including resting- (REE) and total-energy expenditure, (TEE), physical activity level (PAL), percentage of PAL ≥ 3 metabolic equivalent tasks (METs), number of steps, resting index (RI%) and sleeping patterns in 44 free-living nonagenarians (27 men) residing in a Sardinian village famous for its longevous population. The average REE and TEE recorded were: men 1278 ± 161 kcal/day and 957 ± 110, and women: 2286 ± 541kcal/day and 1811 ± 308 in the women, respectively...
July 17, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28714416/application-of-kinase-inhibitors-for-anti-aging-intervention
#17
Mercedes Cano, Antonio Ayala, Francesco Marotta, Sandro Argüelles
Protein phosphorylation, mediated by protein kinases, has important physiological and pathological implications in our lives . Targeting kinase is one of the most interesting of the emerging topics in the pharmaceutical industry, especially since there is a focus on cancer therapy. Given that kinases may be involved in the aging process the focus will be on using the kinase inhibitor for anti-aging intervention to enhance healthspan and increase longevity. In this review , we will summarize: (i) the impact of the phosphoproteomic approach to elucidate molecular mechanisms of diseases; (ii) importance of the drug discovery approach for targeting kinases; (iii) the dysregulation of Janus kinase (JAK) / signal-transducing adapter molecules (STAT) and p70 ribosomal protein S6 kinase (S6Ks) pathway in aging and the age-related process; (iv) the epidemiological studies available in order to see whether a correlation between JAK/STAT and S6Ks mRNA expression levels exist in cancer and in patient outcome; (v) finally, we will show selected inhibitors of these kinases approved by the US Food and Drug Administration (FDA)...
July 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28713422/computational-analysis-of-lifespan-experiment-reproducibility
#18
Michael Petrascheck, Dana L Miller
Independent reproducibility is essential to the generation of scientific knowledge. Optimizing experimental protocols to ensure reproducibility is an important aspect of scientific work. Genetic or pharmacological lifespan extensions are generally small compared to the inherent variability in mean lifespan even in isogenic populations housed under identical conditions. This variability makes reproducible detection of small but real effects experimentally challenging. In this study, we aimed to determine the reproducibility of C...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28713397/fitness-outcomes-related-to-glyphosate-resistance-in-kochia-kochia-scoparia-what-life-history-stage-to-examine
#19
Omobolanle Adewale Osipitan, Johanna Anita Dille
A fast-spreading weed, kochia (Kochia scoparia), has developed resistance to the widely-used herbicide, glyphosate. Understanding the relationship between the occurrence of glyphosate resistance caused by multiple EPSPS gene copies and kochia fitness may suggest a more effective way of controlling kochia. A study was conducted to assess fitness cost of glyphosate resistance compared to susceptibility in kochia populations at different life history stages, that is rate of seed germination, increase in plant height, days to flowering, biomass accumulation at maturity, and fecundity...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28712152/teeth-bleaching-with-low-concentrations-of-hydrogen-peroxide-6-and-catalyzed-by-led-blue-450%C3%A2-%C3%A2-%C3%A2-10-nm-and-laser-infrared-808%C3%A2-%C3%A2-%C3%A2-10-nm-light-for-in-office-treatment-randomized-clinical-trial-1-year-follow-up
#20
Patricio Vildósola, Jessica Bottner, Francisca Avalos, Isidora Godoy, Javier Martín, Eduardo Fernández
OBJECTIVES: The aim of this study was to evaluate color longevity after a year of in-office bleaching with gel (6% hydrogen peroxide HP, LED blue/laser infrared activation system) compared to a 35% control concentration in a split-mouth study model. MATERIALS AND METHODS: Thirty-one patients were initially treated. The bleaching procedure with 6% or 35% gel HP was performed randomly in the upper half arcade of each patient. The color was measured at baseline and at 1 week, 1 month, and 1 year using the spectrophotometer Vita Easyshade, Vita Bleached, and Vita classical Shade guide organized by value...
July 16, 2017: Journal of Esthetic and Restorative Dentistry
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