Leilei Zhang, Xiaolin Huang, Xiaowei Zhu, Shengfang Ge, Eric Gilson, Renbing Jia, Jing Ye, Xianqun Fan
Meibomian gland carcinoma (MGC) and basal cell carcinoma (BCC) are common eyelid carcinomas that exhibit highly dissimilar degrees of proliferation and prognoses. We address here the question of the differential mechanisms between these two eyelid cancers that explain their different outcome. A total of 102 confirmed MGC and 175 diagnosed BCC cases were analyzed. Twenty confirmed MGC and twenty diagnosed BCC cases were collected to determine the telomere length, the presence of senescent cells, and the expression levels of the telomere capping shelterin complex, P53, and the E3 ubiquitin ligase Siah1...
March 15, 2016: International Journal of Cancer. Journal International du Cancer