Dana M Klug, Edwin G Tse, Daniel G Silva, Yafeng Cao, Susan A Charman, Jyoti Chauhan, Elly Crighton, Maria Dichiara, Chris Drake, David Drewry, Flavio da Silva Emery, Lori Ferrins, Lee Graves, Emily Hopkins, Thomas A C Kresina, Álvaro Lorente-Macías, Benjamin Perry, Richard Phipps, Bruno Quiroga, Antonio Quotadamo, Giada N Sabatino, Anthony Sama, Andreas Schätzlein, Quillon J Simpson, Jonathan Steele, Julia Shanu-Wilson, Peter Sjö, Paul Stapleton, Christopher J Swain, Alexandra Vaideanu, Huanxu Xie, William Zuercher, Matthew H Todd
Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing the world, yet the private sector finds it challenging to generate much-needed medicines. As an alternative discovery approach, a small array of diarylimidazoles was screened against the ESKAPE pathogens, and the results were made publicly available through the Open Source Antibiotics (OSA) consortium (https://github.com/opensourceantibiotics). Of the 18 compounds tested (at 32 μg/mL), 15 showed >90% growth inhibition activity against methicillin-resistant Staphylococcus aureus (MRSA) alone...
November 22, 2023: ACS Infectious Diseases