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https://www.readbyqxmd.com/read/29142336/multi-atlas-based-ct-synthesis-from-conventional-mri-with-patch-based-refinement-for-mri-based-radiotherapy-planning
#1
Junghoon Lee, Aaron Carass, Amod Jog, Can Zhao, Jerry L Prince
Accurate CT synthesis, sometimes called electron density estimation, from MRI is crucial for successful MRI-based radiotherapy planning and dose computation. Existing CT synthesis methods are able to synthesize normal tissues but are unable to accurately synthesize abnormal tissues (i.e., tumor), thus providing a suboptimal solution. We propose a multi-atlas-based hybrid synthesis approach that combines multi-atlas registration and patch-based synthesis to accurately synthesize both normal and abnormal tissues...
February 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29138536/spotlight-on-siponimod-and-its-potential-in-the-treatment-of-secondary-progressive-multiple-sclerosis-the-evidence-to-date
#2
REVIEW
Alberto Gajofatto
Siponimod (BAF312) is a synthetic molecule belonging to the sphingosine-1-phosphate (S1P) modulator family, which has putative neuroprotective properties and well-characterized immunomodulating effects mediated by sequestration of B and T cells in secondary lymphoid organs. Compared to fingolimod (ie, precursor of the S1P modulators commercially available for the treatment of relapsing-remitting [RR] multiple sclerosis [MS]), siponimod exhibits selective affinity for types 1 and 5 S1P receptor, leading to a lower risk of adverse events that are mainly induced by S1P3 receptor activation, such as bradycardia and vasoconstriction...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29137497/optimization-of-t2-weighted-imaging-for-shoulder-magnetic-resonance-arthrography-by-synthetic-magnetic-resonance-imaging
#3
Seung Hyun Lee, Young Han Lee, Seok Hahn, Jaemoon Yang, Ho-Taek Song, Jin-Suck Suh
Background Synthetic magnetic resonance imaging (MRI) allows reformatting of various synthetic images by adjustment of scanning parameters such as repetition time (TR) and echo time (TE). Optimized MR images can be reformatted from T1, T2, and proton density (PD) values to achieve maximum tissue contrast between joint fluid and adjacent soft tissue. Purpose To demonstrate the method for optimization of TR and TE by synthetic MRI and to validate the optimized images by comparison with conventional shoulder MR arthrography (MRA) images...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29135073/prostate-cancer-detection-using-quantitative-t2-and-t2-weighted-imaging-the-effects-of-5-alpha-reductase-inhibitors-in-men-on-active-surveillance
#4
Francesco Giganti, Giulio Gambarota, Caroline M Moore, Nicola L Robertson, Neil McCartan, Charles Jameson, Simon R J Bott, Mathias Winkler, Brandon Whitcher, Ramiro Castro-Santamaria, Mark Emberton, Clare Allen, Alex Kirkham
BACKGROUND: T2 -weighted imaging (T2 -WI) information has been used in a qualitative manner in the assessment of prostate cancer. Quantitative derivatives (T2 relaxation time) can be generated from T2 -WI. These outputs may be useful in helping to discriminate clinically significant prostate cancer from background signal. PURPOSE/HYPOTHESIS: To investigate changes in quantitative T2 parameters in lesions and noncancerous tissue of men on active surveillance for prostate cancer taking dutasteride 0...
November 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29134354/conventional-and-synthetic-mri-in-multiple-sclerosis-a-comparative-study
#5
Wolfgang Krauss, Martin Gunnarsson, Margareta Nilsson, Per Thunberg
OBJECTIVES: To compare the assessment of patients with multiple sclerosis (MS) using synthetic and conventional MRI. MATERIALS AND METHODS: Synthetic and conventional axial images were prospectively acquired for 52 patients with diagnosed MS. Quantitative MRI (qMRI) was used for measuring proton density and relaxation times (T1, T2) and then, based on these parameters, synthetic T1W, T2W and FLAIR images were calculated. Image stacks were reviewed blindly, independently and in random order by two radiologists...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29126043/biphasic-bioresorbable-scaffold-trufit-plug-%C3%A2-for-the-treatment-of-osteochondral-lesions-of-talus-6-to-8-year-follow-up
#6
Elvira Di Cave, Pierluigi Versari, Fabio Sciarretta, David Luzon, Lorenzo Marcellini
BACKGROUND: The ideal treatment of osteochondral lesions of the talus (OLT) is debatable. The TruFit plug has been investigated as a potential treatment method for osteochondral defects. This is a biphasic scaffold designed to stimulate cartilage and subchondral bone formation. The purpose of this retrospective study was to investigate the long-term functional and MRI outcomes of the TruFit Plug for the treatment of OLT. METHODS: Twelve consecutive patients treated from March 2007 to April 2009 for OLT were evaluated...
June 3, 2017: Foot
https://www.readbyqxmd.com/read/29104968/a-sparse-bayesian-learning-algorithm-for-white-matter-parameter-estimation-from-compressed-multi-shell-diffusion-mri
#7
Pramod Kumar Pisharady, Stamatios N Sotiropoulos, Guillermo Sapiro, Christophe Lenglet
We propose a sparse Bayesian learning algorithm for improved estimation of white matter fiber parameters from compressed (under-sampled q-space) multi-shell diffusion MRI data. The multi-shell data is represented in a dictionary form using a non-monoexponential decay model of diffusion, based on continuous gamma distribution of diffusivities. The fiber volume fractions with predefined orientations, which are the unknown parameters, form the dictionary weights. These unknown parameters are estimated with a linear un-mixing framework, using a sparse Bayesian learning algorithm...
September 2017: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/29101783/one-pot-preparation-of-hydrophilic-manganese-oxide-nanoparticles-as-t1-nano-contrast-agent-for-molecular-magnetic-resonance-imaging-of-renal-carcinoma-in-vitro-and-in-vivo
#8
Jingjing Li, Chen Wu, Pingfu Hou, Min Zhang, Kai Xu
Magnetic resonance imaging (MRI) contrast agents have become a necessary part for clinical practice to improve the sensitivity for the diagnosis of small lesions and injuries. Among them, manganese oxide nanoparticle (MnO NPs)-based MRI contrast agent attracts more and more attention because of their better performance in the detection of brain disease and positive enhancement in T1-weighted image. However, the relatively low r1 relaxivity and complex synthetic route hampered their wider applications. In this work, we proposed a one-pot approach to prepare hydrophilic MnO NPs via a polyol-like method with poly (ethylene glycol) (PEG) as both a solvent and surfactant...
October 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29100938/generative-diffeomorphic-modelling-of-large-mri-data-sets-for-probabilistic-template-construction
#9
Claudia Blaiotta, Patrick Freund, M Jorge Cardoso, John Ashburner
In this paper we present a hierarchical generative model of medical image data, which can capture simultaneously the variability of both signal intensity and anatomical shapes across large populations. Such a model has a direct application for learning average-shaped probabilistic tissue templates in a fully automated manner. While in principle the generality of the proposed Bayesian approach makes it suitable to address a wide range of medical image computing problems, our work focuses primarily on neuroimaging applications...
October 31, 2017: NeuroImage
https://www.readbyqxmd.com/read/29077399/last-step-pd-mediated-11-c-co-labeling-of-a-moxestrol-conjugated-o-iodobenzyl-alcohol-from-model-experiments-to-in-vivo-positron-emission-tomography-studies
#10
Thomas Cornilleau, Mette Simonsen, Maylou Vang, Nada Taib-Maamar, Jean Dessolin, Hélène Audrain, Philippe Hermange, Eric Fouquet
The fast, efficient, and functional group tolerant last-step radiolabeling of bioconjugates is crucial for positron emission tomography (PET) applications. In this context, o-iodobenzyl alcohol based structures were identified as ideal tags for an easy Pd-catalyzed carbonylation after bioconjugation, and a moxestrol-conjugated precursor was chosen as the model compound for the further studies. Despite scale and time constraints, conditions developed with [(12)C]CO and [(13)C]CO were easily transferred to the (11)C isotope, and the desired radioactive product was obtained in amounts up to 740 MBq with radiochemical purities higher than 99%...
October 27, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29072503/a-segmentation-of-brain-mri-images-utilizing-intensity-and-contextual-information-by-markov-random-field
#11
Mingsheng Chen, Qingguang Yan, Mingxin Qin
BACKGROUND AND OBJECTIVE: Image segmentation is a preliminary and fundamental step in computer aided magnetic resonance imaging (MRI) images analysis. But the performance of most current image segmentation methods is easily depreciated by noise in MRI images. A precise and anti-noise segmentation of MRI images is desired in modern medical image diagnosis. METHODS: This paper presents a segmentation of MRI images which combines fuzzy clustering and Markov random field (MRF)...
October 26, 2017: Computer Assisted Surgery (Abingdon, England)
https://www.readbyqxmd.com/read/29072345/rational-design-of-branched-au-fe3o4-janus-nanoparticles-for-simultaneous-trimodal-imaging-and-photothermal-therapy-of-cancer-cells
#12
Xiangjun Chen, Guilan Li, Qinghe Han, Xiliang Li, Lu Li, Tingting Wang, Chungang Wang
We report a facile and simple hydrogen reduction method to fabricate PEGylated branched gold (Au)-iron oxide (Fe3O4) Janus nanoparticles (JNPs). Note that, the hydrogen induces the formation of Fe3O4 during the synthesis process. Due to the strong absorption in the near-infrared range, branched Au-Fe3O4 JNPs showed a significant photothermal effect with a 40% calculated photothermal transduction efficiency under a laser irradiation of 808 nm in vitro. Owing to their excellent optical and magnetic properties, branched Au-Fe3O4 JNPs were demonstrated to be advantageous agents for triple-modal magnetic resonance imaging (MRI)/photoacoustic imaging (PAI)/computed tomography (CT) in vitro...
October 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29060865/simultaneous-estimation-of-the-in-mean-and-in-variance-causal-connectomes-of-the-human-brain
#13
A Duggento, L Passamonti, M Guerrisi, N Toschi
In recent years, the study of the human connectome (i.e. of statistical relationships between non spatially contiguous neurophysiological events in the human brain) has been enormously fuelled by technological advances in high-field functional magnetic resonance imaging (fMRI) as well as by coordinated world wide data-collection efforts like the Human Connectome Project (HCP). In this context, Granger Causality (GC) approaches have recently been employed to incorporate information about the directionality of the influence exerted by a brain region on another...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29060548/low-grade-glioma-growth-modeling-considering-chemotherapy-and-radiotherapy-effects-from-magnetic-resonance-images
#14
Ahmed Elazab, Hongmin Bai, Xiaodong Zhang, Qingmao Hu
Studying tumor growth using mathematical models from magnetic resonance (MR) images is an important application that is believed to play a major role in cancer treatment by predicting tumor evolution, quantifying the response to therapy, and treatment planning. Reaction diffusion is the most popular model because of its simplicity and consistency with the biological growth process. However, most of the current growth models focus on presurgical images and likely without treatment. In this paper, we propose a new reaction diffusion model to consider the chemotherapy and radiotherapy effects on the tumor growth modelling for patients with low grade glioma...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29053451/spatially-resolved-mr-compatible-doppler-ultrasound-proof-of-concept-for-triggering-of-diagnostic-quality-cardiovascular-mri-for-function-and-flow-quantification-at-3t
#15
Lindsey A Crowe, Gibran Manasseh, Aneta Chmielewski, Anne-Lise Hachulla, Daniel Speicher, Andreas Greiser, Hajo Muller, Thomas De Perrot, Jean-Paul Vallee, Rares Salomir
OBJECTIVES: We demonstrate the use of a Magnetic-Resonance (MR)-compatible ultrasound (US) imaging probe using spatially-resolved Doppler for diagnostic quality cardiovascular MR imaging as an initial step towards hybrid US/MR fetal imaging. METHODS: A newly developed technology for a dedicated MR-compatible phased array ultrasound-imaging probe acquired pulsed color Doppler carotid images, which were converted in near-real time to a trigger signal for cardiac cine and flow quantification MRI...
October 17, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29053447/multimodal-mr-synthesis-via-modality-invariant-latent-representation
#16
Agisilaos Chartsias, Thomas Joyce, Mario Valerio Giuffrida, Sotirios A Tsaftaris
We propose a multi-input multi-output fully convolutional neural network model for MRI synthesis. The model is robust to missing data, as it benefits from, but does not require, additional input modalities. The model is trained end-to-end, and learns to embed all input modalities into a shared modalityinvariant latent space. These latent representations are then combined into a single fused representation, which is transformed into the target output modality with a learnt decoder. We avoid the need for curriculum learning by exploiting the fact that the various input modalities are highly correlated...
October 17, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29051552/auditory-evoked-bold-responses-in-awake-compared-to-lightly-anaesthetized-zebra-finches
#17
L Van Ruijssevelt, J Hamaide, M T Van Gurp, M Verhoye, A Van der Linden
Functional magnetic resonance imaging (fMRI) is increasingly used in cognitive neuroscience and has become a valuable tool in the study of auditory processing in zebra finches, a well-established model of learned vocal communication. Due to its sensitivity to head motion, most fMRI studies in animals are performed in anaesthetized conditions, which might significantly impact neural activity evoked by stimuli and cognitive tasks. In this study, we (1) demonstrate the feasibility of fMRI in awake zebra finches and (2) explore how light anaesthesia regimes affect auditory-evoked BOLD responses to biologically relevant songs...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29048157/paramagnetic-19-f-relaxation-enhancement-in-nickel-ii-complexes-of-n-trifluoroethyl-cyclam-derivatives-and-cell-labeling-for-19-f-mri
#18
Jan Blahut, Karel Bernášek, Andrea Gálisová, Vít Herynek, Ivana Císařová, Jan Kotek, Jan Lang, Stanislava Matějková, Petr Hermann
1,8-Bis(2,2,2-trifluoroethyl)cyclam (te2f) derivatives with two coordinating pendant arms involving methylenecarboxylic acid (H2te2f2a), methylenephosphonic acid (H4te2f2p), (2-pyridyl)methyl (te2f2py), and 2-aminoethyl arms (te2f2ae) in 4,11-positions were prepared, and their nickel(II) complexes were investigated as possible (19)F MR tracers. The solid-state structures of several synthetic intermediates, ligands, and all complexes were confirmed by X-ray diffraction analysis. The average Ni···F distances were determined to be about 5...
November 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29047975/breast-density-quantification-using-structured-light-based-diffuse-optical-tomography-simulations
#19
Jessica Ruiz, Farouk Nouizi, Jaedu Cho, Jie Zheng, Yifan Li, Jeon-Hor Chen, Min-Ying Su, Gultekin Gulsen
We present the feasibility of structured-light-based diffuse optical tomography (DOT) to quantify the breast density with an extensive simulation study. This study is performed on multiple numerical breast phantoms built from magnetic resonance imaging (MRI) images. These phantoms represent realistic tissue morphologies and are given typical breast optical properties. First, synthetic data are simulated at five wavelengths using our structured-light-based DOT forward problem. Afterwards, the inverse problem is solved to obtain the absorption images and subsequently the chromophore concentration maps...
September 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29035039/synthesis-of-water-dispersible-mn-2-functionalized-silicon-nanoparticles-under-room-temperature-and-atmospheric-pressure-for-fluorescence-and-magnetic-resonance-dual-modality-imaging
#20
Ya-Kun Dou, Yang Chen, Xi-Wen He, Wen-You Li, Yu-Hao Li, Yu-Kui Zhang
Silicon nanoparticles (Si NPs) have been widely used in fluorescence imaging. However, rigorous synthesis conditions and the single modality imaging limit the further development of Si NPs in the field of biomedical imaging. Here, we reported a method for synthesizing water-dispersible Mn(2+) functionalized Si NPs (Mn-Si NPs) under mild experimental conditions for fluorescence and magnetic resonance dual-modality imaging. The whole synthesis process was completed under room temperature and atmospheric pressure, and no special and expensive equipment was required...
November 7, 2017: Analytical Chemistry
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