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https://www.readbyqxmd.com/read/29780615/feasibility-of-synthetic-mri-in-knee-imaging-in-routine-practice
#1
Sana Boudabbous, Angeliki Neroladaki, Ilias Bagetakos, Marion Hamard, Bénédicte Ma Delattre, Maria Isabel Vargas
Background: Synthetic magnetic resonance (MR) is a method allowing reduction of examination time and access to quantitative imaging. Purpose: This study sought to assess the image quality and diagnostic accuracy of synthetic magnetic resonance imaging (MRI) compared to standard MRI in patients with knee pain. Material and Methods: In total, 22 patients underwent standard 1.5 knee MRI with an added synthetic sequence. Quantitative T1, T2, and proton density (PD) images were generated synthetically; T1, PD, and short tau inversion recovery (STIR) weighted images were created with chosen echo time (TE), repetition time (TR), and inversion time (TI)...
May 2018: Acta Radiologica Open
https://www.readbyqxmd.com/read/29774597/assessment-of-the-generalization-of-learned-image-reconstruction-and-the-potential-for-transfer-learning
#2
Florian Knoll, Kerstin Hammernik, Erich Kobler, Thomas Pock, Michael P Recht, Daniel K Sodickson
PURPOSE: Although deep learning has shown great promise for MR image reconstruction, an open question regarding the success of this approach is the robustness in the case of deviations between training and test data. The goal of this study is to assess the influence of image contrast, SNR, and image content on the generalization of learned image reconstruction, and to demonstrate the potential for transfer learning. METHODS: Reconstructions were trained from undersampled data using data sets with varying SNR, sampling pattern, image contrast, and synthetic data generated from a public image database...
May 17, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29756411/hexarelin-treatment-preserves-myocardial-function-and-reduces-cardiac-fibrosis-in-a-mouse-model-of-acute-myocardial-infarction
#3
Hayley McDonald, Jason Peart, Nyoman Kurniawan, Graham Galloway, Simon Royce, Chrishan S Samuel, Chen Chen
Ischemic heart disease (IHD) is a leading cause of morbidity and mortality worldwide. Growth hormone secretagogues (GHS) have been shown to improve cardiac function in models of IHD. This study determined whether hexarelin (HEX), a synthetic GHS, preserves cardiac function and morphology in a mouse model of myocardial infarction (MI). MI was induced by ligation of the left descending coronary artery in C57BL/6J mice followed by vehicle (VEH; n = 10) or HEX (0.3 mg/kg/day; n = 11) administration for 21 days...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29743525/design-characterization-and-in-vivo-performance-of-synthetic-2-mm-diameter-vessel-grafts-made-of-pva-gelatin-blends
#4
M Atlan, T Simon-Yarza, J M Ino, V Hunsinger, L Corté, P Ou, R Aid-Launais, M Chaouat, D Letourneur
Since the development of the first vascular grafts, fabrication of vessel replacements with diameters smaller than 6 mm remains a challenge. The present work aimed to develop PVA (poly (vinyl alcohol))-gelatin hybrids as tubes suitable for replacement of very small vessels and to evaluate their performance using a rat abdominal aorta interposition model. PVA-gelatin hybrid tubes with internal and external diameters of 1.4 mm and 1.8 mm, respectively, composed of 4 different gelatin ratios were prepared using a one-step strategy with both chemical and physical crosslinking...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29733917/clinical-equivalence-assessment-of-t2-synthesized-pediatric-brain-magnetic-resonance-imaging
#5
Basile Kerleroux, Tobias Kober, Tom Hilbert, Maxence Serru, Dominique Sirinelli, Baptiste Morel
BACKGROUND AND PURPOSE: Automated synthetic magnetic resonance imaging (MRI) provides qualitative, weighted image contrasts as well as quantitative information from one scan and is well-suited for various applications such as analysis of white matter disorders. However, the synthesized contrasts have been poorly evaluated in pediatric applications. The purpose of this study was to compare the image quality of synthetic T2 to conventional turbo spin echo (TSE) T2 in pediatric brain MRI...
May 4, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29730814/a-novel-synthetic-route-for-high-index-faceted-iron-oxide-concave-nanocubes-with-high-t-2-relaxivity-for-in-vivo-mri-applications
#6
Shu F Situ-Loewenstein, Sameera Wickramasinghe, Eric C Abenojar, Bernadette O Erokwu, Chris A Flask, Zhenghong Lee, Anna Cristina S Samia
Iron oxide nanoparticles (IONPs) with high-index facets have shown great potential as high performance T2 contrast agents for MRI. Previous synthetic approaches focused mainly on ion-directed or oxidative etching methods. Herein, we report a new synthetic route for preparing high-index faceted iron oxide concave nanocubes using a bulky coordinating solvent. Through the systematic replacement of a non-coordinating solvent, 1-octadecene, with trioctylamine, the solvent interaction with the nanoparticle surface is modified, thereby, promoting the growth evolution of the IONPs from spherical to concave cubic morphology...
May 5, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29728885/gadopentatic-acid-affects-in-vitro-proliferation-and-doxorubicin-response-in-human-breast-adenocarcinoma-cells
#7
Abdel Rahman Abdel Fattah, Sarah Mishriki, Tobias Kammann, Rakesh P Sahu, Fei Geng, Ishwar K Puri
Contrasting agents (CAs) that are administered to patients during magnetic resonance imaging to facilitate tumor identification are generally considered harmless. However, gadolinium (Gd) based contrast agents can be retained in the body, inflicting specific cell line cytotoxicity. We investigate the effect of Gadopentatic acid (Gd-DTPA) on human breast adenocarcinoma MCF-7 cells. These cells exhibit a toggle switch response: exposure to 0.1 and 1 mM concentrations of Gd-DTPA enhances proliferation, which is hindered at a higher 10 mM concentration...
May 5, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29724180/joint-sparse-reconstruction-of-multi-contrast-mri-images-with-graph-based-redundant-wavelet-transform
#8
Zongying Lai, Xinlin Zhang, Di Guo, Xiaofeng Du, Yonggui Yang, Gang Guo, Zhong Chen, Xiaobo Qu
BACKGROUND: Multi-contrast images in magnetic resonance imaging (MRI) provide abundant contrast information reflecting the characteristics of the internal tissues of human bodies, and thus have been widely utilized in clinical diagnosis. However, long acquisition time limits the application of multi-contrast MRI. One efficient way to accelerate data acquisition is to under-sample the k-space data and then reconstruct images with sparsity constraint. However, images are compromised at high acceleration factor if images are reconstructed individually...
May 3, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29722063/a-discrete-polar-stockwell-transform-for-enhanced-characterization-of-tissue-structure-using-mri
#9
Glen Pridham, Martijn D Steenwijk, Jeroen J G Geurts, Yunyan Zhang
PURPOSE: The purpose of this study was to present an effective algorithm for computing the discrete polar Stockwell transform (PST), investigate its unique multiscale and multi-orientation features, and explore potentially new applications including denoising and tissue segmentation. THEORY AND METHODS: We investigated PST responses using both synthetic and MR images. Moreover, we compared the features of PST with both Gabor and Morlet wavelet transforms, and compared the PST with two wavelet approaches for denoising using MRI...
May 2, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29719854/intravoxel-incoherent-motion-ivim-and-non-gaussian-diffusion-mri-of-the-lactating-breast
#10
Mami Iima, Masako Kataoka, Rena Sakaguchi, Shotaro Kanao, Natsuko Onishi, Makiko Kawai, Akane Ohashi, Katsutoshi Murata, Kaori Togashi
Purpose: To investigate the effect of breastfeeding on IVIM and non-Gaussian diffusion MRI in the breast. Materials and methods: An IRB approved prospective study enrolled seventeen volunteers (12 in lactation and 5 with post-weaning, range 31-43 years; mean 35.4 years). IVIM (fIVIM and D*) and non-Gaussian diffusion (ADC0 and K) parameters using 16 b values, plus synthetic apparent diffusion coefficients (sADCs) from 2 key b values (b = 200 and 1500 s/mm2 ) were calculated using regions of interest...
2018: European Journal of Radiology Open
https://www.readbyqxmd.com/read/29700795/changes-in-the-adc-of-diffusion-weighted-mri-with-the-oscillating-gradient-spin-echo-ogse-sequence-due-to-differences-in-substrate-viscosities
#11
Tomoko Maekawa, Masaaki Hori, Katsutoshi Murata, Thorsten Feiweier, Issei Fukunaga, Christina Andica, Akifumi Hagiwara, Koji Kamagata, Saori Koshino, Osamu Abe, Shigeki Aoki
PURPOSE: Compared with the conventional pulsed gradient spin-echo (PGSE) sequence, diffusion-weighted imaging (DWI) with the oscillating gradient spin-echo (OGSE) sequence can shorten the diffusion time by changing the frequency. The purpose was to investigate whether n-alkanes are suitable as isotropic phantoms for estimating the diffusion coefficient with the OGSE sequence. MATERIALS AND METHODS: We investigated changes in the apparent diffusion coefficient (ADC) due to differences in the viscosities of nine n-alkane phantoms with different numbers of carbon atoms from C8 H18 to C16 H34 using OGSE and PGSE sequences at 21 °C...
April 26, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29696555/desmopressin-induced-severe-hyponatremia-with-central-pontine-myelinolysis-a-case-report
#12
Tanzib Hossain, Marya Ghazipura, Vineet Reddy, Pedro J Rivera, Vikramjit Mukherjee
Desmopressin, a synthetic vasopressin analog, is used to treat central diabetes insipidus, hemostatic disorders such as von Willebrand's disease, and nocturnal enuresis. We present the case of a 69-year-old man who developed severe hyponatremia during treatment with intranasal desmopressin at 10 µg twice daily for chronic polyuria and nocturia thought to be due to central diabetes insipidus. After 5 months of therapy, the patient noticed progressive fatigue, anorexia, dizziness, weakness, light-headedness, decreased concentration, and new-onset falls...
April 25, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29689381/on-the-use-of-superparamagnetic-hydroxyapatite-nanoparticles-as-an-agent-for-magnetic-and-nuclear-in-vivo-imaging
#13
Alessio Adamiano, Michele Iafisco, Monica Sandri, Martina Basini, Paolo Arosio, Tamara Canu, Giovanni Sitia, Antonio Esposito, Vincenzo Iannotti, Giovanni Ausanio, Eirini Fragogeorgi, Maritina Rouchota, George Loudos, Alessandro Lascialfari, Anna Tampieri
The identification of alternative biocompatible magnetic NPs for advanced clinical application is becoming an important need due to raising concerns about iron accumulation in soft issues associated to the administration of superparamagnetic iron oxide nanoparticles (NPs). Here, we report on the performance of previously synthetized iron-doped hydroxyapatite (FeHA) NPs as contrast agent for magnetic resonance imaging (MRI). The MRI contrast abilities of FeHA and Endorem® (dextran coated iron oxide NPs) were assessed by 1 H nuclear magnetic resonance relaxometry and their performance in healthy mice was monitored by a 7 Tesla scanner...
April 21, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29682610/the-empirical-effect-of-gaussian-noise-in-undersampled-mri-reconstruction
#14
Patrick Virtue, Michael Lustig
In Fourier-based medical imaging, sampling below the Nyquist rate results in an underdetermined system, in which a linear reconstruction will exhibit artifacts. Another consequence is lower signal-to-noise ratio (SNR) because of fewer acquired measurements. Even if one could obtain information to perfectly disambiguate the underdetermined system, the reconstructed image could still have lower image quality than a corresponding fully sampled acquisition because of reduced measurement time. The coupled effects of low SNR and underdetermined system during reconstruction makes it difficult to isolate the impact of low SNR on image quality...
December 2017: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/29682499/paracest-agents-encapsulated-in-reverse-nano-assembled-capsules-racs-how-slow-molecular-tumbling-can-quench-cest-contrast
#15
Annah Farashishiko, Jacqueline R Slack, Mauro Botta, Mark Woods
Although paraCEST is a method with immense scope for generating image contrast in MRI, it suffers from the serious drawback of high detection limits. For a typical discrete paraCEST agent the detection limit is roughly an order of magnitude higher than that of a clinically used relaxation agent. One solution to this problem may be the incorporation of a large payload of paraCEST agents into a single macromolecular agent. Here we report a new synthetic method for accomplishing this goal: incorporating a large payload of the paraCEST agent DyDOTAM3+ into a Reverse Assembled nano-Capsule...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29679804/cytotoxicity-of-paramagnetic-cations-loaded-polydopamine-nanoparticles
#16
Milena A Vega, Celia Nieto, Gema Marcelo, Eva M Martín Del Valle
Polydopamine (PD) is a synthetic melanin pigment of great importance in biomedicine, where its affinity for metallic cations, especially paramagnetic ions, has sparked interest in its use in the development of magnetic resonance imaging (MRI) contrast agents. In this work, we report the cytotoxicity of metal-enriched PD nanoparticles on NIH3T3, a healthy cell line and BT474, a breast cancer cell line. Remarkably, it was found that the metal- enriched PD particles (Mn+  = Fe3+ , Fe2+ and Cu2+ ) were highly cytotoxic to the breast cancer cells, even after 24 h of treatment...
April 12, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29677161/fast-gpu-pcc-a-gpu-based-technique-to-compute-pairwise-pearson-s-correlation-coefficients-for-time-series-data-fmri-study
#17
Taban Eslami, Fahad Saeed
Functional magnetic resonance imaging (fMRI) is a non-invasive brain imaging technique, which has been regularly used for studying brain’s functional activities in the past few years. A very well-used measure for capturing functional associations in brain is Pearson’s correlation coefficient. Pearson’s correlation is widely used for constructing functional network and studying dynamic functional connectivity of the brain. These are useful measures for understanding the effects of brain disorders on connectivities among brain regions...
April 20, 2018: High-throughput
https://www.readbyqxmd.com/read/29673893/a-new-discrete-dipole-kernel-for-quantitative-susceptibility-mapping
#18
Carlos Milovic, Julio Acosta-Cabronero, José Miguel Pinto, Hendrik Mattern, Marcelo Andia, Sergio Uribe, Cristian Tejos
PURPOSE: Most approaches for quantitative susceptibility mapping (QSM) are based on a forward model approximation that employs a continuous Fourier transform operator to solve a differential equation system. Such formulation, however, is prone to high-frequency aliasing. The aim of this study was to reduce such errors using an alternative dipole kernel formulation based on the discrete Fourier transform and discrete operators. METHODS: The impact of such an approach on forward model calculation and susceptibility inversion was evaluated in contrast to the continuous formulation both with synthetic phantoms and in vivo MRI data...
April 16, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29665440/mri-compatible-ms2-nanoparticles-designed-to-cross-the-blood-brain-barrier-providing-a-path-towards-tinnitus-treatment
#19
Aaron K Apawu, Stephanie M Curley, Angela R Dixon, Mirabela Hali, Moaz Sinan, Rod D Braun, James Castracane, Anthony T Cacace, Magnus Bergkvist, Avril Genene Holt
Fundamental challenges of targeting specific brain regions for treatment using pharmacotherapeutic nanoparticle (NP) carriers include circumventing the blood-brain-barrier (BBB) and tracking delivery. Angiopep-2 (AP2) has been shown to facilitate the transport of large macromolecules and synthetic nanoparticles across the BBB. Thus, conjugation of AP2 to an MS2 bacteriophage based NP should also permit transport across the BBB. We have fabricated and tested a novel MS2 capsid-based NP conjugated to the ligand AP2...
April 14, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29615790/multivariate-granger-causality-unveils-directed-parietal-to-prefrontal-cortex-connectivity-during-task-free-mri
#20
Andrea Duggento, Luca Passamonti, Gaetano Valenza, Riccardo Barbieri, Maria Guerrisi, Nicola Toschi
While a large body of research has focused on the study of functional brain "connectivity", few investigators have focused on directionality of brain-brain interactions which, in spite of the mostly bidirectional anatomical substrates, cannot be assumed to be symmetrical. We employ a multivariate Granger Causality-based approach to estimating directed in-network interactions and quantify its advantages using extensive realistic synthetic BOLD data simulations to match Human Connectome Project (HCP) data specification...
April 3, 2018: Scientific Reports
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