Matthias Lüke, Margit Henry, Thea Lingohr, Mehran Maghsoodian, Jürgen Hescheler, Marco Weiergräber, Werner Sickel, Toni Schneider
BACKGROUND: Voltage-dependent Ca(2+) channels trigger and control important cellular processes like neurotransmitter release and secretion, long-term potentiation, and gene expression in excitable cells. During retinal signal perception and processing, presynaptic Ca(2+) channels facilitate neurotransmitter release in photoreceptors and bipolar neurons, at nonspiking synapses which generate graded potentials. METHODS: The nature of voltage-gated Ca(2+) channels involved in retinal signal transduction is investigated in the present report by recording the electroretinogram (ERG) from the isolated and perfused bovine retina...
September 2005: Graefe's Archive for Clinical and Experimental Ophthalmology