Nadeev Wijesuriya, Vishal Mehta, Felicity De Vere, Sandra Howell, Steven A Niederer, Haran Burri, Johannes Sperzel, Leonardo Calo, Bernard Thibault, Wenjiao Lin, Kwangdeok Lee, Andrea Grammatico, Niraj Varma, Marianne Gwechenberger, Christophe Leclercq, Christopher A Rinaldi
BACKGROUND: Studies have reported that female sex predicts superior cardiac resynchronization therapy (CRT) response. One theory is that this association is related to smaller female heart size, thus increased "relative dyssynchrony" at given QRS durations (QRSd). OBJECTIVE: To investigate the mechanisms of sex-specific CRT response relating to heart size, relative dyssynchrony, cardiomyopathy type, QRS morphology, and other patient characteristics. METHODS: A post-hoc analysis of the MORE-CRT MPP trial (n=3739, 28% female), with a sub-group analysis of patients with non-ischaemic cardiomyopathy (NICM) and left bundle branch block (LBBB) (n=1308, 41% female) to control for confounding characteristics...
December 6, 2023: medRxiv