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Prostate cancer and ultrasound

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https://www.readbyqxmd.com/read/28635568/additional-value-of-magnetic-resonance-targeted-biopsies-to-standard-transrectal-ultrasound-guided-biopsies-for-detection-of-clinically-significant-prostate-cancer
#1
Catrin von Below, Cecilia Wassberg, Mona Norberg, Anna Tolf, Joel Kullberg, Sam Ladjevardi, Michael Häggman, Anna Bill Axelson, Håkan Ahlström
OBJECTIVE: The aim of this study was to evaluate the additional value of magnetic resonance imaging-targeted biopsy (MRI-TB) to standard transrectal ultrasound-guided biopsy (SB) for detection of clinically significant prostate cancer (PCa). An additional aim was to compare the biopsy results to MRI evaluation using a Likert scale. MATERIALS AND METHODS: Patients with newly diagnosed localized PCa (n = 53) by clinical routine SB were prospectively included. The majority of the patients were scheduled for curative therapy before enrollment...
February 24, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28635336/new-advances-in-focal-therapy-for-early-stage-prostate-cancer
#2
Kae Jack Tay, Ariel A Schulman, Christina Sze, Efrat Tsivian, Thomas J Polascik
Prostate focal therapy offers men the opportunity to achieve oncological control while preserving sexual and urinary function. The prerequisites for successful focal therapy are to accurately identify, localize and completely ablate the clinically significant cancer(s) within the prostate. We aim to evaluate the evidence for current and upcoming technologies that could shape the future of prostate cancer focal therapy in the next five years. Areas Covered: Current literature on advances in patient selection using imaging, biopsy and biomarkers, ablation techniques and adjuvant treatments for focal therapy are summarized...
June 21, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28634789/detection-and-grading-of-prostate-cancer-using-temporal-enhanced-ultrasound-combining-deep-neural-networks-and-tissue-mimicking-simulations
#3
Shekoofeh Azizi, Sharareh Bayat, Pingkun Yan, Amir Tahmasebi, Guy Nir, Jin Tae Kwak, Sheng Xu, Storey Wilson, Kenneth A Iczkowski, M Scott Lucia, Larry Goldenberg, Septimiu E Salcudean, Peter A Pinto, Bradford Wood, Purang Abolmaesumi, Parvin Mousavi
PURPOSE  : Temporal Enhanced Ultrasound (TeUS) has been proposed as a new paradigm for tissue characterization based on a sequence of ultrasound radio frequency (RF) data. We previously used TeUS to successfully address the problem of prostate cancer detection in the fusion biopsies. METHODS  : In this paper, we use TeUS to address the problem of grading prostate cancer in a clinical study of 197 biopsy cores from 132 patients. Our method involves capturing high-level latent features of TeUS with a deep learning approach followed by distribution learning to cluster aggressive cancer in a biopsy core...
June 20, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28629785/-interest-using-3d-ultrasound-and-mri-fusion-biopsy-for-prostate-cancer-detection
#4
A Marien, A De Castro Abreu, I Gill, A Villers, O Ukimura
INTRODUCTION: The strategic therapy for prostate cancer depends on histo-pronostics data, which could be upgraded by obtaining targeted biopsies (TB) with MRI (magnetic resonance imagery) fusion 3D ultrasound. OBJECTIVES: To compare diagnostic yield of image fusion guided prostate biopsy using image fusion of multi-parametric MRI (mpMRI) with 3D-TRUS. MATERIALS AND METHODS: Between January 2010 and April 2013, 179 consecutive patients underwent outpatient TRUS biopsy using the real-time 3D TRUS tracking system (Urostation™)...
June 16, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28621672/the-predictive-efficacy-of-hypoechoic-lesion-in-ultrasound-for-prostate-cancer-in-chinese-people-five-year-experience-in-a-moderated-10-core-transperineal-prostate-biopsy-procedure
#5
Yang Tian, Zhang Limin, Chen Yixin, Cai Yehua, Jiang Haowen, Ding Qiang
We aim to investigate the predictive efficacy of hypoechoic lesion for prostate cancer at different levels of serum PSA in the procedure of transrectal ultrasound guided 10-core trans-perineal prostate biopsy (TP-PBx). In this study, we collected clinical parameters involving age, digital rectal examination (DRE), PSA, prostate volume, pathological diagnosis, Gleason score, novel Gleason group, and numbers of positive cores from 856 patients who had elevated level of PSA above 4 ng/ml or susceptible nodule of prostate gland in DRE received the moderated 10-core TP-PBx procedure...
June 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28616050/occult-cancer-in-patients-with-deep-vein-thrombosis-in-a-general-hospital-at-mexico-city-a-pilot-study
#6
Christian O Ramírez-Serrano Torres, Edgardo Román-Guzmán, Carlos-Manuel Ortiz-Mendoza
BACKGROUND: We aimed to explore the frequency of occult cancer in patients with deep-vein thrombosis (DVT) at a general hospital in Mexico City. MATERIALS AND METHODS: From March 2012 to February 2015, all patients with primary DVT of lower extremities attended in the emergency department of our hospital were studied. Initially, all patients were evaluated with clinical history, physical examination, basic laboratories, abdominal ultrasound, chest X-ray, and duplex venous ultrasonography...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28613202/-comparison-of-two-on-line-risk-calculators-versus-the-detection-of-circulating-prostate-cells-for-the-detection-of-high-risk-prostate-cancer-at-first-biopsy
#7
Nigel P Murray, Cynthia Fuentealba, Eduardo Reyes, Omar Jacob
OBJECTIVE: The limitations of total serum PSA values remains problematic; nomograms may improve the prediction of a positive prostate biopsy (PB). We compare in a prospective study of Chilean men with suspicion of prostate cancer due to an elevated total serum PSA and/or abnormal digital rectal examination, the use of two on-line nomograms with the detection of primary malignant circulating prostate cells (CPCs) to predict a positive PB for high risk prostate cancer. METHODS: Consecutive men with suspicion of prostate cancer underwent 12 core TRUS prostate biopsy...
June 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28609110/monitoring-tumor-volume-in-patients-with-prostate-cancer-undergoing-active-surveillance-is-mri-apparent-diffusion-coefficient-indicative-of-tumor-growth
#8
Veronica A Morgan, Christopher Parker, Alison MacDonald, Karen Thomas, Nandita M deSouza
OBJECTIVE: The purpose of this study was to measure longitudinal change in tumor volume of the dominant intraprostatic lesion and determine whether baseline apparent diffusion coefficient (ADC) and change in ADC are indicative of tumor growth in patients with prostate cancer undergoing active surveillance. SUBJECTS AND METHODS: The study group included 151 men (mean age, 68.1 ± 7.4 [SD] years; range, 50-83 years) undergoing active surveillance with 3D whole prostate, zonal, and tumor volumetric findings documented at endorectal MRI examinations performed at two time points (median interval, 1...
June 13, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28594074/testosterone-and-dihydrotestosterone-levels-in-the-transition-zone-correlate-with-prostate-volume
#9
Tomislav Pejčić, Tomislav Tosti, Živoslav Tešić, Borivoj Milković, Dejan Dragičević, Milutin Kozomara, Milica Čekerevac, Zoran Džamić
BACKGROUND: There is still no consensus regarding intraprostatic androgen levels and the accumulation of androgens in the hyperplastic prostatic tissue. The current opinion is that intraprostatic dihydrotestosterone (DHT) concentrations are maintained but not elevated in benign prostatic hyperplasia (BPH), while there is no similar data concerning intraprostatic testosterone (T). METHODS: Tissue T (tT) and tissue DHT (tDHT) concentration were determined in 93 patients scheduled for initial prostate biopsy...
June 8, 2017: Prostate
https://www.readbyqxmd.com/read/28588732/trus-guided-transperineal-prostate-12-x-core-biopsy-with-template-for-the-diagnosis-of-prostate-cancer
#10
Gang Guo, Yong Xu, Xu Zhang
The objective of the present study was to explore the clinical value and safety of trans-rectal ultrasound (TRUS)-guided transperineal prostate 12+X core biopsy in the diagnosis of prostate cancer. Patients who received a TRUS-guided transperineal prostate biopsy for suspected prostate cancer at the General Hospital of The People's Liberation Army between September 2009 and May 2014 were retrospectively analyzed, this consisted of 1,300 patients. These patients were randomly divided into the 12+X core group or the standard 12-core group...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28582803/a-random-walk-based-segmentation-framework-for-3d-ultrasound-images-of-the-prostate
#11
Ling Ma, Rongrong Guo, Zhiqiang Tian, Baowei Fei
PURPOSE: Accurate segmentation of the prostate on ultrasound images has many applications in prostate cancer diagnosis and therapy. Transrectal ultrasound (TRUS) has been routinely used to guide prostate biopsy. This manuscript proposes a semiautomatic segmentation method for the prostate on three-dimensional (3D) TRUS images. METHODS: The proposed segmentation method uses a context-classification based, random walk algorithm. Because context information reflects patient-specific characteristics and prostate changes in the adjacent slices, and classification information reflects population-based prior knowledge, we combine the context and classification information at the same time in order to define the applicable population and patient-specific knowledge so as to more accurately determine the seed points for the random walk algorithm...
June 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/28579687/therapeutic-ultrasound-and-prostate-cancer
#12
REVIEW
Karthik M Sundaram, Sam S Chang, David F Penson, Sandeep Arora
Therapeutic ultrasound approaches including high-intensity focused ultrasound (HIFU) are emerging as popular minimally invasive alternative treatments for localized, low-to-intermediate risk prostate cancer. FDA approval was recently granted for two ultrasound-guided HIFU devices. Clinical trials for devices using MRI guidance are ongoing. The current level of evidence for whole-gland ultrasound ablation suggests that its clinical efficacy and adverse event rates including erectile dysfunction and urinary incontinence are similar to current definitive therapies such as radical prostatectomy and external-beam radiotherapy...
June 2017: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/28579419/the-effect-of-catheter-displacement-and-anatomical-variations-on-the-dose-distribution-in-mri-guided-focal-hdr-brachytherapy-for-prostate-cancer
#13
Metha Maenhout, Jochem R N van der Voort van Zyp, Maxence Borot de Battisti, Max Peters, Marco van Vulpen, Maurice van den Bosch, Marinus A Moerland
PURPOSE: The aim of this study was to analyze the effect of catheter displacement and anatomical variations of prostate and organs at risk on dose distribution in MRI-guided 19 Gy single fraction focal high-dose-rate brachytherapy (HDR-BT) of the prostate. METHODS AND MATERIALS: Seventeen patients with localized prostate cancer were enrolled in a prospective trial investigating focal HDR-BT in a 1.5 T MRI-HDR-BT facility. The diagnostic MRI delineations were registered with intraoperative MR scan, and a single fraction of 19 Gy was applied to the visible tumor...
June 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28570099/accuracy-and-interobserver-agreement-for-prostate-imaging-reporting-and-data-system-version-2-for-the-characterization-of-lesions-identified-on-multiparametric-mri-of-the-prostate
#14
Andrei S Purysko, Leonardo K Bittencourt, Jennifer A Bullen, Thomaz R Mostardeiro, Brian R Herts, Eric A Klein
OBJECTIVE: The objective of this study was to measure the accuracy and interobserver agreement of the Prostate Imaging Reporting and Data System, version 2 (PI-RADSv2), for the characterization of prostate lesions on multiparametric MRI. MATERIALS AND METHODS: This retrospective study included 170 men examined at a single institution between August 2014 and February 2015 on a 3-T MRI scanner. Study patients were found to have lesions concerning for prostate cancer that were targeted for MRI/transrectal ultrasound fusion biopsy...
June 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28567329/carcinosarcoma-of-the-tunica-vaginalis-following-radiation-therapy-for-localized-prostate-cancer
#15
Charles D Viers, Subodh M Lele, Tara Kirkpatrick, Chad A LaGrange
Spermatic cord tumors (SCTs) are rare neoplasms with 80% exhibiting benign pathology. Of the malignant SCTs, 90% are sarcomas. To date there has only been one documented case of primary CS of the spermatic cord which occurred in a 40 year old with no reported medical history. A 76-year-old male with a history of biopsy proven Gleason score 7 (3 + 4) prostatic adenocarcinoma underwent external beam radiation therapy (7920 cGy) in 44 fractions in 2004. He presented with a 3 year history of an asymptomatic right hydrocele...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28566201/racial-variation-in-the-outcome-of-subsequent-prostate-biopsies-in-men-with-an-initial-diagnosis-of-atypical-small-acinar-proliferation
#16
Robert Scott Libby, Jordan J Kramer, Hoang Minh Tue Nguyen, Allison Feibus, Raju Thomas, Jonathan L Silberstein
BACKGROUND: African American (AA) men are known to have more aggressive prostate cancer (PCa) compared with Caucasian American men. We sought to determine predictors of subsequent detection and risk stratification of PCa in a racially diverse group of men with atypical small acinar proliferation (ASAP) on initial prostate biopsy. MATERIALS AND METHODS: A retrospective analysis was conducted on data from men with ASAP on initial prostate biopsy who subsequently received confirmatory biopsies between September 2000 and July 2015...
April 26, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28562371/the-role-of-the-multiparametric-mri-in-the-diagnosis-of-prostate-cancer-in-biopsy-na%C3%A3-ve-men
#17
Adrian Rhudd, Jean McDonald, Mark Emberton, Veeru Kasivisvanathan
PURPOSE OF REVIEW: To review the role of prebiopsy multiparametric MRI in biopsy-naïve men for the detection of clinically significant prostate cancer. RECENT FINDINGS: Recent level 1 evidence shows that multiparametric MRI has high sensitivity and negative predictive value for the detection of clinically significant prostate cancer in biopsy-naïve men. Concurrent developments include important work in the standardization of MRI reporting. The low specificity and positive predictive value of MRI means that biopsy is still necessary following MRI...
May 29, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28552089/magnetic-resonance-imaging-guided-biopsies-may-improve-diagnosis-in-biopsy-naive-men-with-suspicion-of-prostate-cancer
#18
Mads Dochedahl Winther, Ingegerd Balslev, Lars Boesen, Vibeke Logager, Nis Noergaard, Karen-Cecilie Duus Thestrup, Henrik S Thomsen
INTRODUCTION: The purpose of this pilot study was to investigate whether a short prostate biparametric magnetic resonance imaging (bp-MRI) protocol provides a valuable diagnostic addition for biopsy guidance in biopsy-naive men with a suspicion of prostate cancer (PCa). METHODS: A total of 62 biopsy-naive patients referred to a systematic transrectal ultrasound biopsy (TRUS-bx) due to suspicion of PCa were prospectively enrolled. Bp-MRI was performed before biopsy...
May 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28551679/multiparametric-mri-trus-fusion-prostate-biopsy-advantages-of-a-transperineal-approach
#19
Pietro Pepe, Antonio Garufi, Gian Domenico Priolo, Michele Pennisi
BACKGROUND/AIM: To evaluate the detection rate for clinically-significant prostate cancer (PCa) of transperineal (TP) vs. transrectal (TR) multiparametric MRI/TRUS (magnetic resonance imaging/transrectal ultrasound) fusion targeted-biopsy. PATIENTS AND METHODS: From January 2016 to December 2016, 150 men underwent repeat saturation transperineal prostate biopsy (SPBx; median 30 cores) combined with targeted mpMRI/TRUS TR and TP fusion biopsies (4 cores for each procedure) of suspicious MRI lesions (PI-RADS 3/5)...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28546032/application-of-prostate-imaging-reporting-and-data-system-version-2-pi-rads-v2-interobserver-agreement-and-positive-predictive-value-for-localization-of-intermediate-and-high-grade-prostate-cancers-on-multiparametric-magnetic-resonance-imaging
#20
Frank Chen, Steven Cen, Suzanne Palmer
RATIONALE AND OBJECTIVES: To evaluate interobserver agreement with the use of and the positive predictive value (PPV) of Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) for the localization of intermediate- and high-grade prostate cancers on multiparametric magnetic resonance imaging (mpMRI). MATERIALS AND METHODS: In this retrospective, institutional review board-approved study, 131 consecutive patients who had mpMRI followed by transrectal ultrasound-MR imaging fusion-guided biopsy of the prostate were included...
May 22, 2017: Academic Radiology
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