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JOURNAL ARTICLE
Donald Tan, Rance J T Fujiwara, Kenneth H Lee
Cochlear implants (CIs) have demonstrated a clear functional benefit in children with severe-to-profound sensorineural hearing loss (SNHL) and thus have gained wide acceptance for treating deafness in the pediatric population. When evaluating young children for cochlear implantation, there are unique considerations beyond the standard issues addressed during surgery in adults. Because of advances in genetic testing, imaging resolution, CI technology, post-implant rehabilitation, and other factors, issues related to CI surgery in children continue to evolve...
April 2024: Journal of Audiology & Otology
#22
JOURNAL ARTICLE
Jun Ho Lee
No abstract text is available yet for this article.
April 2024: Journal of Audiology & Otology
#23
JOURNAL ARTICLE
Norashikin Chahed, Ahmad Aidil Arafat Dzulkarnain, Saiful Adli Jamaluddin
BACKGROUND: Auditory brainstem response (ABR) to the level-specific (LS) CE-Chirp has been reported to provide optimum neural synchrony along cochlear partitions, theoretically improving ABR waveform resolution. Despite this promising finding, limited studies have been conducted to contrast the results between LS CE-Chirp and Click stimuli. The current study aimed to compare the results of ABR between the two stimuli (Click and LS CE-Chirp). METHOD: Sixty-seven normal-hearing infants, both with and without risk factors, aged less than 7 months old, participated in this study...
April 2024: Malaysian Journal of Medical Sciences: MJMS
#24
JOURNAL ARTICLE
Sriram Hemachandran, Ning Hu, Catherine J Kane, Steven H Green
INTRODUCTION: Cochlear afferent synapses connecting inner hair cells to spiral ganglion neurons are susceptible to excitotoxic trauma on exposure to loud sound, resulting in a noise-induced cochlear synaptopathy (NICS). Here we assessed the ability of cyclic AMP-dependent protein kinase (PKA) signaling to promote cochlear synapse regeneration, inferred from its ability to promote axon regeneration in axotomized CNS neurons, another system refractory to regeneration. METHODS: We mimicked NICS in vitro by applying a glutamate receptor agonist, kainic acid (KA) to organotypic cochlear explant cultures and experimentally manipulated cAMP signaling to determine whether PKA could promote synapse regeneration...
2024: Frontiers in Cellular Neuroscience
#25
JOURNAL ARTICLE
Sarah S Connell, Richard N Chang, Kathryn E Royse, Nicholas J Benson, LenhAnh P Tran, Brian H Fasig, Liz W Paxton, Ben J Balough
OBJECTIVE: We assessed three cochlear implant (CI) suppliers: Advanced Bionics, Cochlear Limited, and MED-EL, for implant revision requiring reoperation after CI placement. STUDY DESIGN: Retrospective cohort study of integrated-health-system database between 2010 and 2021. Separate models were created for pediatric (age <18) and adult (age ≥18) cohorts. PATIENTS: Pediatric (age <18) and adult (age ≥18) patients undergoing cochlear implantation within our integrated healthcare system...
May 1, 2024: Otology & Neurotology
#26
JOURNAL ARTICLE
Jacob de Nobel, Savine S M Martens, Jeroen J Briaire, Thomas H W Bäck, Anna V Kononova, Johan H M Frijns
This study introduces and evaluates the PHAST+ model, part of a computational framework designed to simulate the behavior of auditory nerve fibers in response to the electrical stimulation from a cochlear implant. PHAST+ incorporates a highly efficient method for calculating accommodation and adaptation, making it particularly suited for simulations over extended stimulus durations. The proposed method uses a leaky integrator inspired by classic biophysical nerve models. Through evaluation against single-fiber animal data, our findings demonstrate the model's effectiveness across various stimuli, including short pulse trains with variable amplitudes and rates...
April 24, 2024: Hearing Research
#27
JOURNAL ARTICLE
Brett M Colbert, Cris Lanting, Molly Smeal, Susan Blanton, Derek M Dykxhoorn, Pei-Ciao Tang, Richard L Getchell, Hedwig Velde, Mirthe Fehrmann, Ryan Thorpe, Prem Chapagain, Heidy Elkhaligy, Hannie Kremer, Helger Yntema, Lonneke Haer-Wigman, Shelby Redfield, Tieqi Sun, Saskia Bruijn, Astrid Plomp, Thadé Goderie, Jiddeke van de Kamp, Rolien H Free, Jolien Klein Wassink-Ruiter, Josine Widdershoven, Els Vanhoutte, Liselotte Rotteveel, Marjolein Kriek, Marieke van Dooren, Lies Hoefsloot, Heriette H W de Gier, Amanda Schaefer, Diana Kolbe, Hela Azaiez, Grace Rabie, Armal Aburayyan, Mariana Kawas, Moien Kanaan, Jourdan Holder, Shin-Ichi Usami, Zhengyi Chen, Pu Dai, Jeffrey Holt, Rick Nelson, Byung Yoon Choi, Eliot Shearer, Richard J H Smith, Ronald Pennings, Xue Zhong Liu
TMPRSS3-related hearing loss presents challenges in correlating genotypic variants with clinical phenotypes due to the small sample sizes of previous studies. We conducted a cross-sectional genomics study coupled with retrospective clinical phenotype analysis on 127 individuals. These individuals were from 16 academic medical centers across 6 countries. Key findings revealed 47 unique TMPRSS3 variants with significant differences in hearing thresholds between those with missense variants versus those with loss-of-function genotypes...
April 30, 2024: Human Genetics
#28
JOURNAL ARTICLE
Edward W Fisher, Jonathan Fishman
No abstract text is available yet for this article.
May 2024: Journal of Laryngology and Otology
#29
JOURNAL ARTICLE
Zhenghong Bi, Minhui Ren, Yu Zhang, Shunji He, Lei Song, Xiang Li, Zhiyong Liu
The mouse auditory organ cochlea contains two types of sound receptors: inner hair cells (IHCs) and outer hair cells (OHCs). Tbx2 is expressed in IHCs but repressed in OHCs, and neonatal OHCs that misexpress Tbx2 transdifferentiate into IHC-like cells. However, the extent of this switch from OHCs to IHC-like cells and the underlying molecular mechanism remain poorly understood. Furthermore, whether Tbx2 can transform fully mature adult OHCs into IHC-like cells is unknown. Here, our single-cell transcriptomic analysis revealed that in neonatal OHCs misexpressing Tbx2, 85...
April 30, 2024: Journal of Neuroscience
#30
JOURNAL ARTICLE
Armita Adily, Vivienne Marnane, Raaya Tiko, Vijayalakshmi Easwar
OBJECTIVE: Stress levels among caregivers of children with hearing loss could influence caregiver-child interactions and ultimately, children's developmental outcomes. Given the limited understanding of stress levels among caregivers of Australian children with hearing loss, the present study aimed to examine stress in caregivers of 5-year-old children with hearing loss wearing hearing aids or cochlear implants and to identify factors associated with greater stress levels. METHODS: A total of 99 caregivers of 70 hearing aid users and 29 cochlear implant users participated in the study...
March 5, 2024: International Journal of Pediatric Otorhinolaryngology
#31
JOURNAL ARTICLE
Betty S Tsai Do, Matthew L Bush, Heather M Weinreich, Seth R Schwartz, Samantha Anne, Oliver F Adunka, Kaye Bender, Kristen M Bold, Michael J Brenner, Ardeshir Z Hashmi, Teresa A Keenan, Ana H Kim, Denée J Moore, Carrie L Nieman, Catherine V Palmer, Erin J Ross, Kristen K Steenerson, Kevin Y Zhan, Joe Reyes, Nui Dhepyasuwan
OBJECTIVE: Age-related hearing loss (ARHL) is a prevalent but often underdiagnosed and undertreated condition among individuals aged 50 and above. It is associated with various sociodemographic factors and health risks including dementia, depression, cardiovascular disease, and falls. While the causes of ARHL and its downstream effects are well defined, there is a lack of priority placed by clinicians as well as guidance regarding the identification, education, and management of this condition...
May 2024: Otolaryngology—Head and Neck Surgery
#32
JOURNAL ARTICLE
Benjamin D Lovin, Daniel Gorelik, Kenny F Lin, Jeffrey T Vrabec
OBJECTIVE: Vestibular loss is associated with increasing age and hearing loss. Cochlear implantation (CI) may be performed in these patients; however, CI can induce vestibular hypofunction (VH) postoperatively. If CI is performed in the "better balancing ear," patients may experience vestibulopathy from new bilateral VH. The objective of this study was to evaluate the rates of VH in older CI candidates, thereby helping to identify patients at increased risk for bilateral VH after CI. STUDY DESIGN: Retrospective cohort study from 2019 to 2022 of patients age 60 to 80 years old who underwent videonystagmography (VNG)...
April 30, 2024: Otolaryngology—Head and Neck Surgery
#33
JOURNAL ARTICLE
Xuemei Wang, Jiahui Chen, Rui Zhang, Qiong Wu, Mengyun Fan, Wendi Shi, Gaozhong Lou, Qing Zhang
<b/>Unilateral deafness will lead to the decline of children's speech recognition rate, language development retardation and spatial positioning ability, which will have many adverse effects on children's life and study. Cochlear implantation can help children rebuild binaural hearing, and systematic audiological evaluation after operation is particularly important for clinicians to evaluate the hearing recovery of children. In this study, a variety of commonly used audiological evaluation, testing processes and methods after cochlear implantation in children with unilateral deafness are described in detail, and the related research status and results are summarized...
May 2024: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
#34
JOURNAL ARTICLE
Zhifeng Liu, Xiaode Lin, Hongming Huang, Guangyuan Dong, Peina Wu
Objective: To investigate the predictive value of temporal bone high-resolution CT（HRCT） multiplanar reconstruction（MPR） for cerebrospinal fluid（CSF） gusher during cochlear implantation in patients with inner ear malformation. Methods: The clinical data of 33 patients（36 ears） with inner ear malformation who underwent cochlear implantation were retrospectively analyzed. The predictive value of HRCT for cerebrospinal fluid gusher during cochlear implantation was evaluated...
May 2024: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
#35
JOURNAL ARTICLE
Xinyue Zou, Shujin Xue, Xingmei Wei, Biao Chen, Yongxin Li
<b/>The difficulty of cochlear implantation in patients with congenital microtia is usually increased due to the vague anatomical marks and facial nerve malformation. The common types of facial nerve malformation include facial nerve bony cover loss, aberrant position, and bifurcation malformation. Bifurcation malformation may obscure the oval window, press against stapes, and bifurcate in the vestibular window while obscuring the round window. It is important to correctly identify the facial nerve and choose a reasonable surgical approach to avoid postoperative complications...
May 2024: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
#36
JOURNAL ARTICLE
Fawen Zhang, Kelli McGuire, Madeline Skeeters, Matthew Barbara, Pamara F Chang, Nanhua Zhang, Jing Xiang, Bin Huang
BACKGROUND AND OBJECTIVES: : A cochlear implant (CI) is an effective prosthetic device used to treat severe-to-profound hearing loss. The present study examined cognitive function in CI users by employing a web-based cognitive testing platform, i.e., BrainCheck, and explored the correlation between cognitive function and subjective evaluation of hearing. SUBJECTS AND METHODS: : Forty-two CI users (mean age: 58.90 years) were surveyed in the subjective evaluation of hearing, and 20/42 participated in the BrainCheck cognitive tests (immediate recognition, Trail Making A, Trail Making B, Stroop, digit symbol substitution, and delayed recognition)...
April 30, 2024: Journal of Audiology & Otology
#37
JOURNAL ARTICLE
Chi Yhun Lo, Robyn Clay-Williams, Beth Elks, Chris Warren, Frances Rapport
INTRODUCTION: The disclosure of deafness is complex, given the historic and on-going stigma associated with being deaf. The aim of this study was to explore how identity, stigma, and quality of life may be impacted when using cochlear implants (CIs) and totally implantable cochlear implants (TICIs). The physical difference between these two assistive listening devices is significant, given many CI users opt to hide their sound processor behind hair or headwear, in contrast to TICIs (an emerging technology) whereby all components are implanted internally and thus invisible...
June 2024: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
#38
JOURNAL ARTICLE
Betty S Tsai Do, Matthew L Bush, Heather M Weinreich, Seth R Schwartz, Samantha Anne, Oliver F Adunka, Kaye Bender, Kristen M Bold, Michael J Brenner, Ardeshir Z Hashmi, Ana H Kim, Teresa A Keenan, Denée J Moore, Carrie L Nieman, Catherine V Palmer, Erin J Ross, Kristen K Steenerson, Kevin Y Zhan, Joe Reyes, Nui Dhepyasuwan
OBJECTIVE: Age-related hearing loss (ARHL) is a prevalent but often underdiagnosed and undertreated condition among individuals aged 50 and above. It is associated with various sociodemographic factors and health risks including dementia, depression, cardiovascular disease, and falls. While the causes of ARHL and its downstream effects are well defined, there is a lack of priority placed by clinicians as well as guidance regarding the identification, education, and management of this condition...
May 2024: Otolaryngology—Head and Neck Surgery
#39
JOURNAL ARTICLE
Betty S Tsai Do, Kaye Bender, Teresa A Keenan, Catherine V Palmer, Erin J Ross, Joe Reyes, Nui Dhepyasuwan
The plain language summary explains age-related hearing loss to patients, families, and care partners. The summary is for any patient aged 50 years and older, families, and care partners. It is based on the 2024 "Clinical Practice Guideline: Age-Related Hearing Loss." This plain language summary is a companion publication to the full guideline, which provides greater detail for clinicians. Guidelines and their recommendations may not apply to every patient, but they can be used to find best practices and quality improvement opportunities...
May 2024: Otolaryngology—Head and Neck Surgery
#40
JOURNAL ARTICLE
Ellison J Goodrich, Michael R Deans
The planar polarized organization of hair cells in the vestibular maculae is unique because these sensory organs contain two groups of cells with oppositely oriented stereociliary bundles that meet at a Line of Polarity Reversal (LPR). EMX2 is a transcription factor expressed by one hair cell group that reverses the orientation of their bundles, thereby forming the LPR. We generated Emx2-CreERt2 transgenic mice for genetic lineage tracing and demonstrate Emx2 expression before hair cell specification when the nascent utricle and saccule constitute a continuous prosensory domain...
April 29, 2024: Development
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