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Kidney reflux

Birong Li, Babitha Haridas, Ashley R Jackson, Hanna Cortado, Nicholas Mayne, Rebecca Kohnken, Brad Bolon, Kirk M McHugh, Andrew L Schwaderer, John D Spencer, Christina B Ching, David S Hains, Sheryl S Justice, Santiago Partida-Sanchez, Brian Becknell
Acquired renal scarring occurs in a subset of patients following febrile urinary tract infections and is associated with hypertension, proteinuria, and chronic kidney disease. Limited knowledge of histopathology, immune cell recruitment and gene expression changes during pyelonephritis restricts the development of therapies to limit renal scarring. Here, we address this knowledge gap using immunocompetent mice with vesicoureteral reflux. Transurethral inoculation of uropathogenic Escherichia coli in C3H/HeOuJ mice leads to renal mucosal injury, tubulointerstitial nephritis, and cortical fibrosis...
October 19, 2016: American Journal of Physiology. Renal Physiology
Neslihan Karakurt, Nesrin Beşbaş, Ali Cansu Bozacı, Yelda Bilginer, Hasan Serkan Doğan, Serdar Tekgül
This study was performed to evaluate the role of postnatal ultrasonography (US) in predicting the final diagnosis and need of surgery of antenatal hydronephrosis patients. One hundred and twenty six renal units (RUs) of 76 patients with diagnosis of antenatal hydronephrosis (ANH) were studied. An early postnatal US no later than the first week of life was requested. Voiding cystourethrography (VCUG) and/or diuretic renogram (MAG3) was performed in children who had persistent or worsening hydronephrosis to make a certain diagnose of etiology...
November 2015: Turkish Journal of Pediatrics
Wojciech Krajewski, Janusz Dembowski, Anna Kołodziej, Bartosz Małkiewicz, Krzysztof Tupikowski, Michał Matuszewski, Paweł Chudoba, Maria Boratyńska, Marian Klinger, Romuald Zdrojowy
INTRODUCTION: Urological complications after renal transplantation occur in between 2.5% and 30% of all graft recipients. The aim of the study was to present 7 years of experience in urological treatment of patients with a transplanted kidney. We aimed to identify retrospectively late urological complications in renal transplant recipients at a single center and analyze the treatment modalities and their outcome. MATERIAL AND METHODS: Between January 2008 and December 2014, a total of 58 patients after KTX were treated in the Department of Urology because of post-transplant urological complications that occurred during follow-up at the Transplant Outpatient Department...
2016: Central European Journal of Urology
František Liška, Renata Peterková, Miroslav Peterka, Vladimír Landa, Václav Zídek, Petr Mlejnek, Jan Šilhavý, Miroslava Šimáková, Vladimír Křen, Colby G Starker, Daniel F Voytas, Zsuzsanna Izsvák, Michal Pravenec
Recently, it has been found that spontaneous mutation Lx (polydactyly-luxate syndrome) in the rat is determined by deletion of a conserved intronic sequence of the Plzf (Promyelocytic leukemia zinc finger protein) gene. In addition, Plzf is a prominent candidate gene for quantitative trait loci (QTLs) associated with cardiac hypertrophy and fibrosis in the spontaneously hypertensive rat (SHR). In the current study, we tested the effects of Plzf gene targeting in the SHR using TALENs (transcription activator-like effector nucleases)...
2016: PloS One
Linda C Lee, Armando J Lorenzo, Martin A Koyle
Urinary tract infections (UTIs) represent a common bacterial cause of febrile illness in children. Of children presenting with a febrile UTI, 25-40% are found to have vesicoureteral reflux (VUR). Historically, the concern regarding VUR was that it could lead to recurrent pyelonephritis, renal scarring, hypertension, and chronic kidney disease. As a result, many children underwent invasive surgical procedures to correct VUR. We now know that many cases of VUR are low-grade and have a high rate of spontaneous resolution...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Farouk M Nasser, Ahmed M Shouman, Mohammed S ElSheemy, Mohammed A Lotfi, Waseem Aboulela, Mohamed El Ghoneimy, Mohammed Abdelwahab, Ahmed I Shoukry, Waleed Ghoneima, Hany Morsi, Hesham Badawy
OBJECTIVES: To compare outcome of dismembered-pyeloplasty in infants with and without external nephro-ureteric stent (ENUS) for treatment of congenital ureteropelvic junction obstruction (UPJ-O). METHODS: This is a parallel, randomized comparative study between October 2013 and September 2014. 30 infants ≤6 months old with UPJ-O indicated for dismembered-pyeloplasty were randomly assigned (block randomization, closed envelope method) into two groups; group-A (stentless) and group-B (ENUS)...
September 28, 2016: Urology
Mitra Naseri
Crossed renal ectopia is a rare urinary system anomaly which mostly is asymptomatic and is diagnosed incidentally. Urinary obstruction, infection, and neoplasia of the urinary system and nephrolithiasis are main complications of this anomaly. A 6-year-old boy admitted to the hospital with colicky abdominal pain and nausea. Abdominal examination revealed tenderness in right lower quadrant. Urine analysis and culture were normal. Kidney ultrasonography showed right kidney in pelvis cavity with no kidney tissue in left side...
2016: Journal of Renal Injury Prevention
Parsa Yousefichaijan, Fatemeh Dorreh, Someyeh Shahsavari, Abdolghader Pakniyat
INTRODUCTION: Urinary tract infection is the most common genitourinary disease in children so about 40% of the children with urinary tract infection suffering from reflux that caused some consequences such as pyelonephritis and kidney parenchymal injury. OBJECTIVES: This research was conducted to compare the timing of voiding cystourethrogram (VCUG) in children with urinary tract infection in first week and after the first week of urinary tract infection. PATIENTS AND METHODS: This research is a case-control study that both case and control groups include 208 children from 1 month to 12 years old with the complain of urinary tract infection...
2016: Journal of Renal Injury Prevention
M E Carazo-Palacios, M Couselo-Jerez, A Serrano-Durbá, B Pemartín-Comella, C Sangüesa-Nebot, F Estornell-Moragues, C Domínguez-Hinarejos
OBJECTIVES: To assess the need for implementing renal scintigraphy in the diagnosis of the multicystic dysplastic kidney (MCDK) and the safety of its conservative treatment. MATERIAL AND METHODS: A retrospective study of patients with unilateral MCDK was conducted at our centre from January 2005 to August 2015. We calculated the positive predictive value (PPV) of ultrasonography, taking renal scintigraphy and pathology as the gold standard. We calculated a survival curve according to the Kaplan-Meier method to assess the annual probability of spontaneous resolution of the multicystic kidney...
September 22, 2016: Actas Urologicas Españolas
Selçuk Yüksel, Havva Evrengül, Z Birsin Özçakar, Tülay Becerir, Nagihan Yalçın, Emine Korkmaz, Fatih Ozaltin
INTRODUCTION: Studies relating to first-line, early, and long-term eculizumab treatment and outcomes in children with atypical hemolytic uremic syndrome (aHUS) are scarce and unclear. The aim of this case-series study was to evaluate the outcomes of first-line, early, and long-term eculizumab treatment in our aHUS patients. MATERIALS AND METHODS: We reviewed the data from four pediatric patients with aHUS who were treated with eculizumab. In three of them, eculizumab was used as a first-line therapy, and the follow-up period was ≥2 years in three patients...
September 19, 2016: Paediatric Drugs
Jun Li, Jing Xiao, Tiandong Han, Ye Tian, Wenying Wang, Yuan Du
We evaluated the clinical value of flexible ureteroscopic lithotripsy for the treatment of upper urinary tract calculi in infants. Fifty-five infants with upper urinary tract calculi were included in this study: 41 males and 14 females. Retrograde intrarenal surgery was performed by an 8 Fr/30 cm flexible ureterorenoscope (POLY®) combined with a holmium laser. CT scanning or radiography of the kidneys, ureters, and bladder region was performed one month after the operation to confirm the clearance of calculi...
September 15, 2016: Experimental Biology and Medicine
Erkin Serdaroglu, Mahfuz Aydogan, Kadriye Ozdemir, Mustafa Bak
BACKGROUND: Urolithiasis (UL) is a common problem in pediatric nephrology practice. About 9-23% of all pediatric UL cases consist of patients under 1 years old. The aim of the present study was to determine etiologic causes, clinical features and short term prognosis of urolithiasis in the first two years of life. METHODS: Two-hundred children between 0-2 years of age (mean age 10.3±6.1 months) with urolithiasis were included to the study. All children were completely evaluated for urolithiasis etiology...
September 13, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Aisan Nozad, Mohsen Naseri, Mir Bahram Safari, Azam Abd Al Ahadi, Farzaneh Ghaffari
CONTEXT: Traditional Iranian medicine (TIM) is a rich and valuable school of thought that believes medications are not the only effective approach for the treatment of diseases but that nutrition is also important. EVIDENCE ACQUISITION: Our study includes two parts; the first is a book review of the Canon of Medicine by Avicenna (10th and 11th centuries), in which we focus on finding and understanding Avicenna's point of view. In the second part, we searched for "food reduction" as a key word from 2000 to 2015 in databases such as Google Scholar, PubMed, Copernicus, DOAJ, EBSCO-CINAHL, and the Iranian search database Iranmedex for principles of food reduction in classical medicine...
June 2016: Iranian Red Crescent Medical Journal
Luis Furuya-Kanamori, Archie C A Clements, Niki F Foster, Charlotte A Huber, Stacey Hong, Tiffany Harris-Brown, Laith Yakob, David L Paterson, Thomas V Riley
OBJECTIVES: To investigate the prevalence and risk factors for asymptomatic toxigenic (TCD) and non-toxigenic C. difficile (NTCD)-colonisation in a broad cross-section of the general hospital population over a 3-year period. METHODS: Patients without diarrhoea admitted to two Australian tertiary hospitals were randomly selected through six repeated cross-sectional surveys conducted between 2012 and 2014. Stool specimens were cultured under anaerobic conditions and C...
September 8, 2016: Clinical Microbiology and Infection
Monika Miklaszewska, Przemysław Korohoda, Katarzyna Zachwieja, Michał Wolnicki, Małgorzata Mizerska-Wasiak, Dorota Drożdż, Jacek A Pietrzyk
Myelomeningocele (MMC) results from a failure of normal neural tube fusion in early fetal development. Retrospective, observational study of medical data of 54 children treated in Pediatric Nephrology and Urology Clinics for five years was performed. The following data were analyzed: serum creatinine, eGFR, urine analysis, renal scintigraphy (RS), renal ultrasound, and urodynamics. Mean age of studied population: 12.3 years, median of eGFR at the beginning and at the end of survey was 110.25 and 116.5 mL/min/1...
2016: International Journal of Environmental Research and Public Health
Yusuf Saifee, Pranjal Modi
A 24-year-old male presented with voiding lower urinary tract symptoms. On evaluation, the patient was found to have midbulbar urethral stricture and right dysplastic pelvic kidney with right vesicoureteral reflux. A micturating cystourethrogram (MCUG) shows opacification of the right vas deferens along the entire course till the testis. The patient underwent end-to-end urethroplasty. But soon the patient presented with urinary tract infection (UTI) and epididymorchitis in the follow-up period. The patient was explored laparoscopically to remove dysplastic kidney and ectopic vas deferens...
2016: J Endourol Case Rep
E Kara, T Sakaci, E Ahbap, T Sahutoglu, Y Koc, T Basturk, M Sevinc, C Akgol, A O Kayalar, Z A Ucar, A Unsal, N Seyahi
BACKGROUND: The goal of this study was to evaluate posttransplant urinary tract infection (UTI) rates and graft outcome in kidney transplantation for end-stage renal disease (ESRD) due to vesicoureteral reflux (VUR)-related reflux nephropathy (RN) versus chronic glomerulonephritis (CGN). METHODS: A total of 62 patients with ESRD who underwent kidney transplantation for VUR-related RN (VUR-RN group, n = 31; mean ± standard deviation age, 34.1 ± 6.0 years; 58.1% female) or CGN (CGN group, n = 31; mean age, 34...
July 2016: Transplantation Proceedings
Ravindra B Sabnis, Abhishek G Singh, Arvind P Ganpule, Jaspreet S Chhabra, Gopal R Tak, Jaimin H Shah
INTRODUCTION: In the past, urological complications after renal transplantation were associated with significant morbidity. With the development and application of endourological procedures, it is now possible to manage these cases with minimally invasive techniques. MATERIALS AND METHODS: A MEDLINE search for articles published in English using key words for the management of urological complications after renal transplantation was undertaken. Forty articles were selected and reviewed...
July 2016: Indian Journal of Urology: IJU: Journal of the Urological Society of India
Meryem Benzer, Sebnem Tekin Neijmann, Nazlı Dilay Gültekin, Aslı Uluturk Tekin
PURPOSE: Liver-type fatty acid-binding protein is a small cytoplasmic protein which is expressed in the human renal proximal tubular epithelium and synthesized in response to renal tubular injury. The aim of the present study was to investigate the importance of urinary liver-type fatty acid-binding protein levels in children who diagnosed with vesicoureteral reflux. METHODS: Fifty-six patients with vesicoureteral reflux and 51 healthy controls were enrolled to the study...
August 22, 2016: International Urology and Nephrology
Dominique P Germain, Derralynn A Hughes, Kathleen Nicholls, Daniel G Bichet, Roberto Giugliani, William R Wilcox, Claudio Feliciani, Suma P Shankar, Fatih Ezgu, Hernan Amartino, Drago Bratkovic, Ulla Feldt-Rasmussen, Khan Nedd, Usama Sharaf El Din, Charles M Lourenco, Maryam Banikazemi, Joel Charrow, Majed Dasouki, David Finegold, Pilar Giraldo, Ozlem Goker-Alpan, Nicola Longo, C Ronald Scott, Roser Torra, Ahmad Tuffaha, Ana Jovanovic, Stephen Waldek, Seymour Packman, Elizabeth Ludington, Christopher Viereck, John Kirk, Julie Yu, Elfrida R Benjamin, Franklin Johnson, David J Lockhart, Nina Skuban, Jeff Castelli, Jay Barth, Carrolee Barlow, Raphael Schiffmann
BACKGROUND: Fabry's disease, an X-linked disorder of lysosomal α-galactosidase deficiency, leads to substrate accumulation in multiple organs. Migalastat, an oral pharmacologic chaperone, stabilizes specific mutant forms of α-galactosidase, increasing enzyme trafficking to lysosomes. METHODS: The initial assay of mutant α-galactosidase forms that we used to categorize 67 patients with Fabry's disease for randomization to 6 months of double-blind migalastat or placebo (stage 1), followed by open-label migalastat from 6 to 12 months (stage 2) plus an additional year, had certain limitations...
August 11, 2016: New England Journal of Medicine
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