Shabnam Jeibouei, Ali Hojat, Ebrahim Mostafavi, Amir Reza Aref, Alireza Kalbasi, Vahid Niazi, Mohammad Ajoudanian, Farzaneh Mohammadi, Fariba Saadati, Seyed Mohammadreza Javadi, Forough Shams, Maryam Moghaddam, Farshid Karami, Kazem Sharifi, Farid Moradian, Mohammad Esmaeil Akbari, Hakimeh Zali
Intraoperative radiotherapy (IORT) could abrogate cancer recurrences, but the underlying mechanisms are unclear. To clarify the effects of IORT-induced wound fluid on tumor progression, we treated breast cancer cell lines and human-derived tumor spheroids in 2D and microfluidic cell culture systems, respectively. The viability, migration, and invasion of the cells under treatment of IORT-induced wound fluid (WF-RT) and the cells under surgery-induced wound fluid (WF) were compared. Our findings showed that cell viability was increased in spheroids under both WF treatments, whereas viability of the cell lines depended on the type of cells and incubation times...
May 10, 2022: Scientific Reports