keyword
MENU ▼
Read by QxMD icon Read
search

Insl3

keyword
https://www.readbyqxmd.com/read/27888281/the-actions-of-relaxin-family-peptides-on-signal-transduction-pathways-activated-by-the-relaxin-family-peptide-receptor-rxfp4
#1
Sheng Y Ang, Dana S Hutchinson, Bronwyn A Evans, Mohammed A Hossain, Nitin Patil, Ross A D Bathgate, Martina Kocan, Roger J Summers
The relaxin family peptide receptor 4 (RXFP4) is a G protein-coupled receptor (GPCR) expressed in the colorectum with emerging roles in metabolism and appetite regulation. It is activated by its cognate ligand insulin-like peptide 5 (INSL5) that is expressed in enteroendocrine L cells in the gut. Whether other evolutionarily related peptides such as relaxin-2, relaxin-3, or INSL3 activate RXFP4 signal transduction mechanisms with a pattern similar to or distinct from INSL5 is still unclear. In this study, we compare the signaling pathways activated by various relaxin family peptides to INSL5...
November 26, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27882303/ovarian-like-differentiation-in-eutopic-and-ectopic-endometrioses-with-aberrant-fsh-receptor-insl3-and-gata4-6-expression
#2
Baptiste Fouquet, Pietro Santulli, Jean-Christophe Noel, Micheline Misrahi
Endometriosis, the hormone-dependent extrauterine dissemination of endometrial tissue outside the uterus, affects 5-15% of women of reproductive age. Pathogenesis remains poorly understood as well as the estrogen production by endometriotic tissue yielding autocrine growth. Estrogens (E2) are normally produced by the ovaries. We investigated whether aberrant "ovarian-like" differentiation occurred in endometriosis. 69 women, with (n = 38) and without (n = 31) histologically proven endometriosis were recruited...
December 2016: BBA Clinical
https://www.readbyqxmd.com/read/27793455/effects-of-long-acting-gnrh-antagonist-degarelix-acetate-on-plasma-insulin-like-peptide-3-testosterone-and-luteinizing-hormone-concentrations-and-scrotal-circumference-in-male-goats
#3
M A Hannan, N Kawate, Y Fukami, W W P N Weerakoon, E E Büllesbach, T Inaba, H Tamada
We recently reported that plasma insulin-like peptide 3 (INSL3) concentrations increased soon after endogenous and exogenous stimulations of LH in male goats and bulls. However, the effects of LH suppression on INSL3 secretion are unknown in domestic animals. Here, we examined the effects of a long-acting GnRH antagonist (degarelix acetate; 4 mg/kg) on the secretions of plasma INSL3 and testosterone in two phases, an immediate and a long-term phase in male goats (n = 6; aged, 13-16 months). During the immediate phase, blood was taken at 15-minute intervals for 8 hours on Days -5, 0, and 3...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27592693/functional-insulin-like-factor-3-insl3-hormone-receptor-system-in-the-testes-and-spermatozoa-of-domestic-ruminants-and-its-potential-as-a-predictor-of-sire-fertility
#4
Ali M Pitia, Kyoko Uchiyama, Hiroaki Sano, Masashi Kinukawa, Yoshiaki Minato, Hiroshi Sasada, Tetsuya Kohsaka
Insulin-like factor 3 (INSL3) is essential for fetal testis descent, and has been implicated in the testicular and sperm functions in adult males; however, similar functions in domestic ruminants remain largely unknown. This study investigated the functional INSL3 hormone-receptor system in adult ruminant testes and spermatozoa, and explored its potential to diagnose the fertility of sires. Testes and spermatozoa were obtained from fertile bulls, rams and he-goats, whereas subfertile testes and spermatozoa were obtained only from bulls...
September 4, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27566230/expression-profiling-identifies-sertoli-and-leydig-cell-genes-as-fsh-targets-in-adult-zebrafish-testis
#5
Diego Crespo, Luiz H C Assis, Tomasz Furmanek, Jan Bogerd, Rüdiger W Schulz
Spermatogonial stem cells are quiescent, undergo self-renewal or differentiating divisions, thereby forming the cellular basis of spermatogenesis. This cellular development is orchestrated by follicle-stimulating hormone (FSH), through the production of Sertoli cell-derived factors, and by Leydig cell-released androgens. Here, we investigate the transcriptional events induced by Fsh in a steroid-independent manner on the restart of zebrafish (Danio rerio) spermatogenesis ex vivo, using testis from adult males where type A spermatogonia were enriched by estrogen treatment in vivo...
December 5, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27470300/the-testicular-hormones-amh-inhb-insl3-and-testosterone-can-be-independently-deficient-in-older-men
#6
Yih Harng Chong, Michael W Pankhurst, Ian S McLennan
BACKGROUND: Late-onset hypogonadism is symptomatically diverse and not fully explained by circulating testosterone level. The adult testes secrete four distinct hormones (testosterone, AMH, INSL3, and InhB) into the circulation. Testosterone and InhB have proven dynamic regulation, with limited information available for AMH and INSL3. During aging, there is cellular senescence, which may underlie the diversity of hypogonadism. This leads to the postulate that the relative levels (profile) of the four testicular hormones in older men are variable and cannot be evaluated by the measurement of one hormone...
July 28, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27465829/endogenous-inhibins-regulate-steroidogenesis-in-mouse-tm3-leydig-cells-by-altering-smad2-signalling
#7
Yao Wang, Maree Bilandzic, Guck T Ooi, Jock K Findlay, Kaye L Stenvers
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3, as a model of immature Leydig cells. The expression of Inha, Inhba, and Inhbb in TM3 cells was determined by RT-PCR and the production of the inhibin-alpha subunit was confirmed by western blot. Knockdown of Inha expression resulted in significant decreases in the expression of Leydig cell markers Cyp17a1, Cyp11a1, Nr5a1, and Insl3. Western blot showed that activin A, TGFβ1 and TGFβ2 activated SMAD2, and that knockdown of Inha expression in TM3 cells enhanced both activin A- and TGFβ-induced SMAD2 activation...
November 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27354341/fetal-gender-prediction-based-on-maternal-plasma-testosterone-and-insulin-like-peptide-3-concentrations-at-midgestation-and-late-gestation-in-cattle
#8
M Kibushi, N Kawate, Y Kaminogo, M A Hannan, W W P N Weerakoon, M Sakase, M Fukushima, T Seyama, T Inaba, H Tamada
We compared maternal plasma testosterone and insulin-like peptide 3 (INSL3) concentrations between dams carrying a male versus female fetus from early to late gestation and examined the application of maternal hormonal concentrations to fetal gender prediction in dairy and beef cattle. Blood samples were collected from Holstein cows or heifers (N = 31) and Japanese Black beef cows (N = 33) at 1-month intervals at 2 to 8 months of gestation. Fetal gender was confirmed by visual observation of external genitalia of calves just after birth...
October 15, 2016: Theriogenology
https://www.readbyqxmd.com/read/27304064/correction-the-male-fetal-biomarker-insl3-reveals-substantial-hormone-exchange-between-fetuses-in-early-pig-gestation
#9
Andreas Vernunft, Richard Ivell, Kee Heng, Ravinder Anand-Ivell
[This corrects the article DOI: 10.1371/journal.pone.0152689.].
2016: PloS One
https://www.readbyqxmd.com/read/27181934/stimulatory-effects-of-combined-endocrine-disruptors-on-ma-10-leydig-cell-steroid-production-and-lipid-homeostasis
#10
Steven Jones, Annie Boisvert, Andrada Naghi, Françoise Hullin-Matsuda, Peter Greimel, Toshihide Kobayashi, Vassilios Papadopoulos, Martine Culty
Previous work in our laboratory demonstrated that in-utero exposure to a mixture of the phytoestrogen Genistein (GEN), and plasticizer DEHP, induces short- and long-term alterations in testicular gene and protein expression different from individual exposures. These studies identified fetal and adult Leydig cells as sensitive targets for low dose endocrine disruptor (ED) mixtures. To further investigate the direct effects and mechanisms of toxicity of GEN and DEHP, MA-10 mouse tumor Leydig cells were exposed in-vitro to varying concentrations of GEN and MEHP, the principal bioactive metabolite of DEHP...
April 29, 2016: Toxicology
https://www.readbyqxmd.com/read/27162065/are-anti-m%C3%A3-llerian-hormone-and-its-receptor-polymorphism-associated-with-the-hormonal-condition-of-undescended-testes
#11
Marta Diana Komarowska, Robert Milewski, Radosław Charkiewicz, Ewa Matuszczak, Anetta Sulewska, Beata Zelazowska-Rutkowska, Justyna Hermanowicz, Jacek Niklinski, Wojciech Debek, Adam Hermanowicz
PURPOSE: Numerous genetic and endocrine factors are involved in the process of testicular descent, but only a few genetic causes have been reported in human. The aim of this study was to investigate the density and distribution of single nucleotide polymorphisms (SNPs) anti-Müllerian hormone (AMH) and AMHRII receptors in cryptorchid patients and determine potential hormone imbalance connected with undescended testes by assessing the levels of AMH, Insulin-like factor 3 (INSL3) and inhibin B...
March 26, 2016: Advances in Medical Sciences
https://www.readbyqxmd.com/read/27147497/relative-levels-of-the-proprotein-and-cleavage-activated-form-of-circulating-human-anti-m%C3%A3-llerian-hormone-are-sexually-dimorphic-and-variable-during-the-life-cycle
#12
Michael W Pankhurst, Yih Harng Chong, Ian S McLennan
Anti-Müllerian hormone (AMH) is a gonadal hormone, which induces aspects of the male phenotype, and influences ovarian follicular recruitment. AMH is synthesized as a proprotein (proAMH), which is incompletely cleaved to the receptor-competent AMHN ,C AMH ELISAs have not distinguished between proAMH and AMHN ,C; consequently, the physiological ranges of circulating proAMH and AMHN ,C are unknown. A novel proAMH ELISA has been used to assay serum proAMH in humans. Total AMH was also measured, enabling the AMHN ,C concentration to be calculated...
May 2016: Physiological Reports
https://www.readbyqxmd.com/read/27125339/anti-m%C3%A3-llerian-hormone-and-inhibin-a-but-not-inhibin-b-or-insulin-like-peptide-3-may-be-used-as-surrogates-in-the-diagnosis-of-polycystic-ovary-syndrome-in-adolescents-preliminary-results
#13
Aylin Yetim, Çağcıl Yetim, Firdevs Baş, Oğuz Bülent Erol, Gülnaz Çığ, Ahmet Uçar, Feyza Darendeliler
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a common endocrine problem in adolescents with an increasing prevalence of 30%. Pursuing new biomarkers with high specificity and sensitivity in the diagnosis of PCOS in adolescents is currently an active area of research. We aimed to investigate the diagnostic value of anti-Müllerian hormone (AMH), insulin-like peptide-3 (INSL3), inhibin-A (INH-A), and inhibin-B (INH-B) in adolescents with PCOS and also to determine the association, if any, between these hormones and clinical/laboratory findings related with hyperandrogenism...
September 1, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27059798/relaxin-and-insl3-in-the-muscolo-skeletal-system-from-bench-to-bedside
#14
Alberto Ferlin, Luca De Toni, Marco Sandri, Carlo Foresta
Skeletal muscles and bones form a joined functional unit sharing a complex mechanical, biochemical and hormonal crosstalk. A number of factors, including sex hormones, physiologically regulates the musculoskeletal system. Striking gender differences in muscle and bone mass and function are mainly caused by distinct actions exerted by estrogens and androgens. However, relaxin and relaxin-related peptides, such as Insulin-like peptide 3 (INSL3), might contribute to these sex-differences in physiological and pathological conditions (such as osteoporosis and sarcopenia)...
April 5, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27058814/prepubertal-di-n-butyl-phthalate-exposure-alters-sertoli-and-leydig-cell-function-and-lowers-bone-density-in-adult-male-mice
#15
Amanda Bielanowicz, Rachelle W Johnson, Hoey Goh, Sarah C Moody, Ingrid J Poulton, Nic Croce, Kate L Loveland, Mark P Hedger, Natalie A Sims, Catherine Itman
Phthalate exposure impairs testis development and function; however, whether phthalates affect nonreproductive functions is not well understood. To investigate this, C57BL/6J mice were fed 1-500 mg di-n-butyl phthalate (DBP) in corn oil, or vehicle only, daily from 4 to 14 days, after which tissues were collected (prepubertal study). Another group was fed 1-500 mg/kg·d DBP from 4 to 21 days and then maintained untreated until 8 weeks for determination of adult consequences of prepubertal exposure. Bones were assessed by microcomputed tomography and dual-energy X-ray absorptiometry and T by RIA...
July 2016: Endocrinology
https://www.readbyqxmd.com/read/27056416/acute-regulation-of-plasma-insulin-like-peptide-3-concentrations-by-luteinizing-hormone-in-male-goats
#16
M A Hannan, N Kawate, Y Fukami, I N Pathirana, E E Büllesbach, T Inaba, H Tamada
Recently, it was reported that in bulls secretion of insulin-like peptide 3 (INSL3) in blood occurred in a pulsatile manner and was acutely regulated by LH. In the present study, the acute regulation of plasma INSL3 and its temporal relationships with LH and testosterone were examined in six sexually matured male goats using the following experimental design. (1) After stimulating LH release by administering a GnRH analogue, blood levels of LH, INSL3, and testosterone were monitored at 15-minute intervals for 2 hours followed by hourly intervals up to 8 hours...
August 2016: Theriogenology
https://www.readbyqxmd.com/read/27031644/the-male-fetal-biomarker-insl3-reveals-substantial-hormone-exchange-between-fetuses-in-early-pig-gestation
#17
Andreas Vernunft, Richard Ivell, Kee Heng, Ravinder Anand-Ivell
The peptide hormone INSL3 is uniquely produced by the fetal testis to promote the transabdominal phase of testicular descent. Because it is fetal sex specific, and is present in only very low amounts in the maternal circulation, INSL3 acts as an ideal biomarker with which to monitor the movement of fetal hormones within the pregnant uterus of a polytocous species, the pig. INSL3 production by the fetal testis begins at around GD30. At GD45 of the ca. 114 day gestation, a time at which testicular descent is promoted, INSL3 evidently moves from male to female allantoic compartments, presumably impacting also on the female fetal circulation...
2016: PloS One
https://www.readbyqxmd.com/read/26991593/leydig-cells-contribute-to-the-inhibition-of-spermatogonial-differentiation-after-irradiation-of-the-rat
#18
G Shetty, W Zhou, C C Y Weng, S H Shao, M L Meistrich
Irradiation with 6 Gy produces a complete block of spermatogonial differentiation in LBNF1 rats that would be permanent without treatment. Subsequent suppression of gonadotropins and testosterone (T) restores differentiation to the spermatocyte stage; however, this process requires 6 weeks. We evaluated the role of Leydig cells (LCs) in maintenance of the block in spermatogonial differentiation after exposure to radiation by specifically eliminating functional LCs with ethane dimethane sulfonate (EDS). EDS (but not another alkylating agent), given at 10 weeks after irradiation, induced spermatogonial differentiation in 24% of seminiferous tubules 2 weeks later...
May 2016: Andrology
https://www.readbyqxmd.com/read/26940356/combined-steroidogenic-characters-of-fetal-adrenal-and-leydig-cells-in-childhood-adrenocortical-carcinoma
#19
Yasuko Fujisawa, Kimiyoshi Sakaguchi, Hiroyuki Ono, Rie Yamaguchi, Fumiko Kato, Masayo Kagami, Maki Fukami, Tsutomu Ogata
Although childhood adrenocortical carcinomas (c-ACCs) with a TP53 mutation are known to produce androgens, detailed steroidogenic characters have not been clarified. Here, we examined steroid metabolite profiles and expression patterns of steroidogenic genes in a c-ACC removed from the left adrenal position of a 2-year-old Brazilian boy with precocious puberty, using an atrophic left adrenal gland removed at the time of tumorectomy as a control. The c-ACC produced not only abundant dehydroepiandrosterone-sulfate but also a large amount of testosterone via the Δ5 pathway with Δ5-androstenediol rather than Δ4-androstenedione as the primary intermediate metabolite...
May 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/26907321/effects-of-in-utero-exposure-to-dicyclohexyl-phthalate-on-rat-fetal-leydig-cells
#20
Xiaoheng Li, Xiaomin Chen, Guoxin Hu, Linxi Li, Huina Su, Yiyan Wang, Dongxin Chen, Qiqi Zhu, Chao Li, Junwei Li, Mingcang Wang, Qingquan Lian, Ren-Shan Ge
Dicyclohexyl phthalate (DCHP) is one of the phthalate plasticizers. The objective of the present study was to investigate the effects of DCHP on fetal Leydig cell distribution and function as well as testis development. Female pregnant Sprague Dawley dams orally received vehicle (corn oil, control) or DCHP (10, 100, and 500 mg/kg/day) from gestational day (GD) 12 to GD 21. At GD 21.5, testicular testosterone production, fetal Leydig cell number and distribution, testicular gene and protein expression levels were examined...
March 2016: International Journal of Environmental Research and Public Health
keyword
keyword
67077
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"