Aparna Shinde, Shana D Hardy, Dongwook Kim, Saeed Salehin Akhand, Mohit Kumar Jolly, Wen-Hung Wang, Joshua C Anderson, Ryan B Khodadadi, Wells S Brown, Jason T George, Sheng Liu, Jun Wan, Herbert Levine, Christopher D Willey, Casey J Krusemark, Robert L Geahlen, Michael K Wendt
The ability of breast cancer cells to transiently transition between epithelial and mesenchymal states contributes to their metastatic potential. Therefore, driving tumor cells into a stable mesenchymal state, as opposed to complete tumor cell eradication, presents an opportunity to pharmacologically limit disease progression by promoting an asymptomatic state of dormancy. Here, we compare a reversible model of epithelial-mesenchymal transition (EMT) induced by TGFβ to a stable mesenchymal phenotype induced by chronic exposure to the ErbB kinase inhibitor lapatinib...
April 15, 2019: Cancer Research