keyword
MENU ▼
Read by QxMD icon Read
search

NLRP

keyword
https://www.readbyqxmd.com/read/29706799/recent-advances-in-the-molecular-mechanisms-underlying-pyroptosis-in-sepsis
#1
REVIEW
Yu-Lei Gao, Jian-Hua Zhai, Yan-Fen Chai
Sepsis is recognized as a life-threatening organ dysfunctional disease that is caused by dysregulated host responses to infection. Up to now, sepsis still remains a dominant cause of multiple organ dysfunction syndrome (MODS) and death among severe condition patients. Pyroptosis, originally named after the Greek words " pyro " and " ptosis " in 2001, has been defined as a specific programmed cell death characterized by release of inflammatory cytokines. During sepsis, pyroptosis is required for defense against bacterial infection because appropriate pyroptosis can minimize tissue damage...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29683722/recursive-partitioning-with-nonlinear-models-of-change
#2
Gabriela Stegmann, Ross Jacobucci, Sarfaraz Serang, Kevin J Grimm
In this article, we introduce nonlinear longitudinal recursive partitioning (nLRP) and the R package longRpart2 to carry out the analysis. This method implements recursive partitioning (also known as decision trees) in order to split data based on individual- (i.e., cluster) level covariates with the goal of predicting differences in nonlinear longitudinal trajectories. At each node, a user-specified linear or nonlinear mixed-effects model is estimated. This method is an extension of Abdolell et al.'s (2002) longitudinal recursive partitioning while permitting a nonlinear mixed-effects model in addition to a linear mixed-effects model in each node...
April 23, 2018: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/29683202/placental-inflammation-in-pre-eclampsia-by-nod-like-receptor-protein-nlrp-3-inflammasome-activation-in-trophoblasts
#3
G S Stødle, G B Silva, L H Tangerås, L M Gierman, I Nervik, U E Dahlberg, C Sun, M H Aune, L C V Thomsen, L Bjørge, A-C Iversen
Pre-eclampsia is associated with increased levels of cholesterol and uric acid and an inflamed placenta expressing danger-sensing pattern recognition receptors (PRRs). Crystalline cholesterol and uric acid activate the PRR Nod-like receptor protein (NLRP)3 inflammasome to release interleukin (IL)-1β and result in vigorous inflammation. We aimed to characterize crystal-induced NLRP3 activation in placental inflammation and examine its role in pre-eclampsia. We confirmed that serum total cholesterol and uric acid were elevated in pre-eclamptic compared to healthy pregnancies and correlated positively to high sensitivity C-reactive protein (hsCRP) and the pre-eclampsia marker soluble fms-like tyrosine kinase-1 (sFlt-1)...
April 23, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29605095/activated-renal-tubular-wnt-%C3%AE-catenin-signaling-triggers-renal-inflammation-during-overload-proteinuria
#4
Dickson W L Wong, Wai Han Yiu, Kam Wa Chan, Ye Li, Bin Li, Sarah W Y Lok, Makoto M Taketo, Peter Igarashi, Loretta Y Y Chan, Joseph C K Leung, Kar Neng Lai, Sydney C W Tang
Imbalance of Wnt/β-catenin signaling in renal cells is associated with renal dysfunction, yet the precise mechanism is poorly understood. Previously we observed activated Wnt/β-catenin signaling in renal tubules during proteinuric nephropathy with an unknown net effect. Therefore, to identify the definitive role of tubular Wnt/β-catenin, we generated a novel transgenic "Tubcat" mouse conditionally expressing stabilized β-catenin specifically in renal tubules following tamoxifen administration...
March 28, 2018: Kidney International
https://www.readbyqxmd.com/read/29574422/maternal-variants-in-nlrp-and-other-maternal-effect-proteins-are-associated-with-multilocus-imprinting-disturbance-in-offspring
#5
Matthias Begemann, Faisal I Rezwan, Jasmin Beygo, Louise E Docherty, Julia Kolarova, Christopher Schroeder, Karin Buiting, Kamal Chokkalingam, Franziska Degenhardt, Emma L Wakeling, Stephanie Kleinle, Daniela González Fassrainer, Barbara Oehl-Jaschkowitz, Claire L S Turner, Michal Patalan, Maria Gizewska, Gerhard Binder, Can Thi Bich Ngoc, Vu Chi Dung, Sarju G Mehta, Gareth Baynam, Julian P Hamilton-Shield, Sara Aljareh, Oluwakemi Lokulo-Sodipe, Rachel Horton, Reiner Siebert, Miriam Elbracht, Isabel Karen Temple, Thomas Eggermann, Deborah J G Mackay
BACKGROUND: Genomic imprinting results from the resistance of germline epigenetic marks to reprogramming in the early embryo for a small number of mammalian genes. Genetic, epigenetic or environmental insults that prevent imprints from evading reprogramming may result in imprinting disorders, which impact growth, development, behaviour and metabolism. We aimed to identify genetic defects causing imprinting disorders by whole-exome sequencing in families with one or more members affected by multilocus imprinting disturbance...
March 24, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29558930/downregulation-of-the-nlrp3-inflammasome-by-adiponectin-rescues-duchenne-muscular-dystrophy
#6
Raphaël Boursereau, Michel Abou-Samra, Sophie Lecompte, Laurence Noel, Sonia M Brichard
BACKGROUND: The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant activation leads to several inflammatory or immune diseases. Here we investigated the expression of the NLRP inflammasome in skeletal muscle and its contribution to DMD...
March 20, 2018: BMC Biology
https://www.readbyqxmd.com/read/29512688/in-vivo-effects-of-the-nlrp1-nlrp3-inflammasome-pathway-on-latent-respiratory-virus-infection
#7
Yong-Huai Li, Xiang Wei, Shuang Ji, Shu-Yu Gui, Su-Mei Zhang
The present study aimed to investigate the effects of nucleotide-binding domain leucine-rich repeat protein (NLRP)1/NLRP3 inflammasome pathways on latent viral infection of the respiratory tract. A total of 55 BALB/c mice were assigned to the control, bleomycin (BLM)‑treated, murine cytomegalovirus (MCMV), MCMV+BLM and MCMV+BLM+CD4+ T‑cell groups. The viral loads were detected in the salivary glands, kidney, liver and lung tissues via polymerase chain reaction (PCR). The weight, lung coefficient and hydroxyproline (HYP) were detected...
June 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29393464/nlrp1-and-nlrp3-inflammasomes-mediate-lps-atp%C3%A2-induced-pyroptosis-in-knee-osteoarthritis
#8
Ling-Rui Zhao, Run-Lin Xing, Pei-Min Wang, Nong-Shan Zhang, Song-Jiang Yin, Xiao-Chen Li, Li Zhang
Pyroptosis is triggered by inflammasomes after its activation by various inflammatory stimulations, including lipopolysaccharide (LPS) and improper pH. This may result in programmed death of the affected cell. It is well known that NLRP1 and NLRP3 inflammasomes mediate the production of various cytokines in inflammatory disorders; however, it is still unknown whether NLRP1 and NLRP3 inflammasomes can influence the LPS‑induced pyroptosis in the progression of knee osteoarthritis (KOA). In the present study, the correlation between the NLRP inflammasomes and fibroblast‑like synoviocytes (FLSs) pyroptosis was investigated in vivo and in vitro...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29359786/uric-acid-upregulates-the-adiponectin%C3%A2-adiponectin-receptor-1-pathway-in-renal-proximal-tubule-epithelial-cells
#9
Qingmei Yang, Chensheng Fu, Jing Xiao, Zhibin Ye
Adiponectin (APN) is a protein hormone that is primarily derived from adipocytes. It can also be secreted by renal cells. Hypoadiponectinemia has been documented in patients with hyperuricemia, however, whether soluble uric acid (SUA) regulates the expression of APN and APN receptor 1 (AdipoR1) in renal proximal tubule epithelial cells (PTECs) remains to be elucidated. The present study investigated the expression of APN and AdipoR1 in cultured PTECs that were exposed to SUA through immunofluorescence and western blot analysis...
March 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29235163/ultraviolet-b-eye-irradiation-aggravates-atopic-dermatitis-via-adrenocorticotropic-hormone-and-nlrp3-inflammasome-in-nc-nga-mice
#10
Keiichi Hiramoto, Yurika Yamate, Satoshi Yokoyama
BACKGROUND: Ultraviolet (UV) B irradiation has been shown to improve atopic dermatitis (AD). However, the relationship between UVB eye irradiation and AD is not known. This issue was addressed using a mouse model of AD. METHODS: The eyes of NC/Nga mice were irradiated with UVB at a dose of 1.0 kJ/m2 using a 20SE sunlamp for the duration of the experimental period. RESULTS: AD symptoms deteriorated upon UVB eye irradiation. The levels of adrenocorticotropic hormone (ACTH) in the plasma and nucleotide-binding domain and leucine-rich-containing family, pyrin domain-containing (NLRP)3 and neutrophil markers in the skin were increased in UVB-irradiated mice...
December 13, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29228654/lack-of-chemopreventive-effects-of-p2x7r-inhibitors-against-pancreatic-cancer
#11
Altaf Mohammed, Naveena B Janakiram, Venkateshwar Madka, Gopal Pathuri, Qian Li, Rebekah Ritchie, Laura Biddick, Hannah Kutche, Yuting Zhang, Anil Singh, Hariprasad Gali, Stan Lightfoot, Vernon E Steele, Chen S Suen, Chinthalapally V Rao
Pancreatic cancer (PC) is an almost uniformly lethal disease with inflammation playing an important role in its progression. Sustained stimulation of purinergic receptor P2X7 drives induction of NLRP inflammasome activation. To understand the role of P2X7 receptor and inflammasome, we performed transcriptomic analysis of p48Cre/+ -LSL-KrasG12D/+ mice pancreatic tumors by next generation sequencing. Results showed that P2X7R's key inflammasome components, IL-1β and caspase-1 are highly expressed ( p < 0...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207123/nacht-lrr-and-pyd-domains-containing-protein-3-inflammasome-is-activated-and-inhibited-by-berberine-via-toll-like-receptor-4-myeloid-differentiation-primary-response-gene-88-nuclear-factor-%C3%AE%C2%BAb-pathway-in-phorbol-12-myristate-13-acetate-induced-macrophages
#12
Zhouqing Huang, Bozhi Ye, Jibo Han, Fanqi Kong, Peiren Shan, Zhongqiu Lu, Zhouqing Huang, Weijian Huang
The nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP-3) inflammasome has recently emerged as a pivotal regulator of chronic inflammation. The present study investigated the expression of NLRP3 inflammasome in phorbol 12-myristate 13-acetate (PMA)-induced macrophages, and aimed to identify the effects of berberine on the inflammasome. Human monocytic THP-1 cells were pretreated with berberine for 1 h and then induced with PMA for 48 h. Total RNA and protein were collected for reverse transcription-quantitative polymerase chain reaction and western blot analysis, respectively...
February 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29146733/effects-of-chronically-increased-vegf-a-on-the-aging-heart
#13
Alexander G Marneros
Whether approaches to chronically increase VEGF-A in the heart may have beneficial effects and prevent the development of heart failure, in part by improving cardiac perfusion, or whether this increase could have detrimental effects on cardiac performance in the aging heart, has not been tested yet. In this study, a genetic mouse model with a chronic increase in VEGF-A in the heart is shown to have increased cardiac angiogenesis and develop cardiac hypertrophy with enhanced basal cardiac performance with age progression...
March 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29103703/anti-inflammatory-capacity-of-lactobacillus-rhamnosus-gg-in-monophasic-variant-salmonella-infected-piglets-is-correlated-with-impeding-nlrp6-mediated-host-inflammatory-responses
#14
Jiao Yu, Yao-Hong Zhu, Gui-Yan Yang, Wei Zhang, Dong Zhou, Jin-Hui Su, Jiu-Feng Wang
In this study, we investigated the effect of Lactobacillus rhamnosus GG strain (LGG) in ameliorating enteritis in newly weaned pigs following challenge with a monophasic variant of Salmonella enterica serovar Typhimurium (serotyped as 4,[5],12:i:-), which has been linked to disease in humans and livestocks over the past 10 years. In weaned pigs, S. enterica serovar 4,[5],12:i:- induced the mRNA expression of toll like receptor (TLR) 5 and TLR4, while increasing interleukin (IL)-8 and IL-6 mRNA expression in the jejunum...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29097227/the-role-of-the-nlrp3-inflammasome-in-regulation-of-antiviral-responses-to-influenza-a-virus-infection
#15
REVIEW
Soroush T Sarvestani, Julie L McAuley
The innate immune system provides the host with both a dynamic barrier to prevent infection and a means to which rapid anti-microbial responses can be mounted. The inflammasome pathway is a critical host early response mechanism that enables detection of pathogens and initiates production of inflammatory cytokines, inducing recruitment of effector cells to the site of infection. The complete mechanism of inflammasome activation requires two signals: an initial priming step upon detection of pathogen, followed by activation of intracellular pattern recognition receptors critical to the formation of the inflammasome complex...
October 31, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29079203/inflammasomes-and-type-2-diabetes-an-updated-systematic-review
#16
REVIEW
Zahra Sepehri, Zohre Kiani, Mahdi Afshari, Farhad Kohan, Azadeh Dalvand, Saeid Ghavami
Type 2 diabetes (T2D) is a metabolic disorder that is accompanied by chronic inflammation. The main mechanisms and molecular signaling of the induction of inflammation in T2D are still unknown. It seems that intracellular sensors that participate in recognition of endogenous damage associated molecular patterns (DAMPs) play key roles in the induction/stimulation of chronic inflammation in T2D. The Nucleotide-binding oligomerization domain, Leucine-rich Repeat and Pyrin domain containing (NLRP) family and accompanying Inflammasomes are important intracellular receptors of inflammatory pathogens and stress signals that elevate caspase-1-mediated release of IL-1β and IL-18...
October 24, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29067455/hyperbaric-oxygen-alleviates-the-activation-of-nlrp%C3%A2-3%C3%A2-inflammasomes-in-traumatic-brain-injury
#17
Huihui Qian, Qinghe Li, Woda Shi
Growing evidence has demonstrated that the nucleotide‑binding oligomerization domain‑like receptor family pyrin domain containing 3 (NLRP‑3) inflammasome‑mediated inflammatory pathways have been involved in the secondary injury of traumatic brain injury (TBI). In the present study, the authors investigated the effects of hyperbaric oxygen (HBO) therapy on the NLRP‑3 inflammasome pathway following TBI. Following the evaluation of motor deficits and brain edema, the therapeutic effects of HBO on interleukin (IL)‑1β and IL‑18 expression were assessed, as well as NLRP‑3 inflammasome activation following TBI...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28950870/per-os-colchicine-administration-in-cholesterol-fed-rabbits-triglycerides-lowering-effects-without-affecting-atherosclerosis-progress
#18
Vaios Vasileios Kaminiotis, George Agrogiannis, Panagiotis Konstantopoulos, Vasiliki Androutsopoulou, Laskarina Maria Korou, Ioannis S Vlachos, Ismene A Dontas, Despina Perrea, Dimitrios C Iliopoulos
BACKGROUND: Atherosclerosis is a chronic inflammatory disease that is promoted, among others, by pro-inflammatory cytokines such as IL-1β and IL-18 produced by NLRP 3 inflammasome. Development of atherosclerotic lesions is also affected by leptin. Furthermore, inflammasome's action is interfered with other inflammatory diseases, like diabetes. On the other hand, colchicine is reported to act as anti-inflammatory agent inhibiting inflammasome's action and stabilizing atherosclerotic lesions...
September 26, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28916717/nlrps-the-subcortical-maternal-complex-and-genomic-imprinting
#19
David Monk, Marta Sanchez-Delgado, Rosemary Fisher
Before activation of the embryonic genome, the oocyte provides many of the RNAs and proteins required for the epigenetic reprogramming and the transition to a totipotent state. Targeted disruption of a subset of oocyte-derived transcripts in mice results in early embryonic lethality and cleavage stage embryonic arrest as highlighted by the members of the Subcortical Maternal Complex (SCMC). Maternal-effect recessive mutations of NLRP7, KHDC3L and NLRP5 in humans are associated with variable reproductive outcomes, biparental hydatidiform moles (BiHM) and widespread multi-locus imprinting disturbances...
September 15, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28878231/dietary-iron-restriction-alleviates-renal-tubulointerstitial-injury-induced-by-protein-overload-in-mice
#20
Yasumasa Ikeda, Yuya Horinouchi, Hirofumi Hamano, Tasuku Hirayama, Seiji Kishi, Yuki Izawa-Ishizawa, Masaki Imanishi, Yoshito Zamami, Kenshi Takechi, Licht Miyamoto, Keisuke Ishizawa, Ken-Ichi Aihara, Hideko Nagasawa, Koichiro Tsuchiya, Toshiaki Tamaki
Increased proteinuria causes tubulointerstitial injury due to inflammation in chronic kidney disease (CKD). Iron restriction exhibits protective effects against renal dysfunction; however, its effects against protein overload-induced tubulointerstitial damage remain unclear. Here, we investigated dietary iron restriction effect on tubulointerstitial damage in mice with protein-overload tubulointerstitial injury. Renal tubulointerstitial injury in animal model was induced by intraperitoneal injection of an overdose of bovine serum albumin (BSA)...
September 6, 2017: Scientific Reports
keyword
keyword
66557
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"