keyword
MENU ▼
Read by QxMD icon Read
search

Peripheral blood gene expression and atherosclerosis

keyword
https://www.readbyqxmd.com/read/29739101/stat1-and-stat6-act-as-antagonistic-regulators-of-ppar%C3%AE-in-diabetic-patients-with-and-without-cardiovascular-diseases
#1
Imen Bendaya, Aouatef Riahi, Maher Kharat, Saloua Kahla, Wissem Sdiri, Ridha Oueslati
BACKGROUND: The processes that mediate an inflammatory environment and increase atherosclerosis in diabetes are not well understood. Peroxisome proliferator-activated receptors (PPARs) are a subgroup of the nuclear hormone receptor superfamily of ligand-activated transcription factors which play an important role in the pathogenesis of type 2 diabetes mellitus (T2DM) and atherosclerosis. PPARγ promotes changes in lipid metabolism, especially in fatty acid (FA) trafficking, and the activity of PPARγ could be modulated by diabetes phenotype patients...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29739089/mir-342-5p-expression-levels-in-coronary-artery-disease-patients-and-its-association-with-inflammatory-cytokines
#2
Reza Ahmadi, Esfandiar Heidarian, Reza Fadaei, Nariman Moradi, Mojtaba Malek, Soudabeh Fallah
BACKGROUND: Atherosclerosis is a progressive inflammatory disease and is the main underlying mechanism of coronary artery disease (CAD). Immune system cells and cytokines play pivotal roles in the development of atherosclerosis. Several studies have shown the role of microRNA in the inflammatory processes of atherosclerosis, and miR-342-5p has been shown to be involved in macrophage activation during atherosclerosis and cytokine secretion. But until now, there has been no data regarding the association of miR-342-5p with CAD and inflammatory cytokines...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29739060/lower-expression-of-mir-10a-in-coronary-artery-disease-and-its-association-with-pro-anti-inflammatory-cytokines
#3
Nariman Moradi, Reza Fadaei, Reza Ahmadi, Elham Kazemian, Soudabeh Fallah
BACKGROUND: Coronary artery disease (CAD) is the leading cause of death worldwide. Atherosclerosis, the main underlying cause of CAD, is a progressive inflammatory disease. microRNAs play a substantial role in the inflammatory process and pathogenesis of atherosclerosis. miR-155, a widely studied microRNA, is associated with inflammation but there are conflicting data regarding expression of miR-155 in CAD. miR-10a is also one of the key regulators of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway which have not been evaluated in peripheral blood mononuclear cells (PBMCs) of CAD patients...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29737876/microrna-221-222-expression-in-atherosclerotic-coronary-artery-plaque-and-peripheral-blood
#4
Aslıhan Esra Bildirici, Serdal Arslan, Nil Özbilüm Şahin, Öcal Berkan, Osman Beton, Mehmet Birhan Yılmaz
BACKGROUND: Atherosclerosis is a disease of the arterial wall with predilection to some sites on others. MicroRNAs (miRNAs) are a class of the non-coding RNAs regulating the target gene expression at post-transcriptional level. Different miRNAs were found at distinct stages of plaque development and expression of miRNAs' might play an important role in the local behaviour of atherosclerotic plaques. OBJECTIVE: We aimed to investigate and compare mirR-221/222 expression levels in tissues and in circulation in patients with and without overt atherosclerosis...
May 8, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29673593/augmented-neutrophil-extracellular-traps-formation-promotes-atherosclerosis-development-in-socially-defeated-apoe-mice
#5
Keita Yamamoto, Hiroyuki Yamada, Noriyuki Wakana, Masakazu Kikai, Kensuke Terada, Naotoshi Wada, Shinichiro Motoyama, Makoto Saburi, Takeshi Sugimoto, Daisuke Kami, Takehiro Ogata, Masakazu Ibi, Chihiro Yabe-Nishimura, Satoaki Matoba
Depression is an independent risk factor of cardiovascular disease (CVD); however, the causal association remains undefined. We exposed mice to repeated social defeat (RSD) to precipitate depressive-like behaviors, and investigated the effects on atherosclerosis. Eight-week-old male apoE-/- mice were exposed to RSD by housing with a larger CD-1 mouse in a shared home cage. They were subjected to vigorous physical contact daily for 10 consecutive days and fed a high-cholesterol diet (HCD) for 6 weeks. The social interaction ratio and immobility time showed dramatic social avoidance before and after HCD feeding...
June 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29651704/hdac9-polymorphism-alters-blood-gene-expression-in-patients-with-large-vessel-atherosclerotic-stroke
#6
Natasha Shroff, Bradley P Ander, Xinhua Zhan, Boryana Stamova, DaZhi Liu, Heather Hull, Farah R Hamade, Cheryl Dykstra-Aiello, Kwan Ng, Frank R Sharp, Glen C Jickling
The histone deacetylase 9 (HDAC9) polymorphism rs2107595 is associated with an increased risk for large vessel atherosclerotic stroke (LVAS). In humans, there remains a need to better understand this HDAC9 polymorphism's contribution to large vessel stroke. In this pilot study, we evaluated whether the HDAC9 polymorphism rs2107595 is associated with differences in leukocyte gene expression in patients with LVAS. HDAC9 SNP rs2107595 was genotyped in 155 patients (43 LVAS and 112 vascular risk factor controls)...
April 13, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29596498/analyses-of-genome-wide-association-data-cytokines-and-gene-expression-in-african-americans-with-benign-ethnic-neutropenia
#7
Bashira A Charles, Matthew M Hsieh, Adebowale A Adeyemo, Daniel Shriner, Edward Ramos, Kyung Chin, Kshitij Srivastava, Neil A Zakai, Mary Cushman, Leslie A McClure, Virginia Howard, Willy A Flegel, Charles N Rotimi, Griffin P Rodgers
BACKGROUND: Benign ethnic neutropenia (BEN) is a hematologic condition associated with people of African ancestry and specific Middle Eastern ethnic groups. Prior genetic association studies in large population showed that rs2814778 in Duffy Antigen Receptor for Chemokines (DARC) gene, specifically DARC null red cell phenotype, was associated with BEN. However, the mechanism of this red cell phenotype leading to low white cell count remained elusive. METHODS: We conducted an extreme phenotype design genome-wide association study (GWAS), analyzed ~16 million single nucleotide polymorphisms (SNP) in 1,178 African-Americans individuals from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study and replicated from 819 African-American participants in the Atherosclerosis Risk in Communities (ARIC) study...
2018: PloS One
https://www.readbyqxmd.com/read/29584810/identification-of-mir-9-5p-as-direct-regulator-of-abca1-and-hdl-driven-reverse-cholesterol-transport-in-circulating-cd14-cells-of-patients-with-metabolic-syndrome
#8
Simona D'Amore, Jennifer Härdfeldt, Marica Cariello, Giusi Graziano, Massimiliano Copetti, Giuseppe Di Tullio, Marilidia Piglionica, Natasha Scialpi, Carlo Sabbà, Giuseppe Palasciano, Michele Vacca, Antonio Moschetta
Aims & Methods: metabolic syndrome is a cluster of cardio-metabolic risk factors associated to atherosclerosis and low-grade inflammation. Using unbiased expression screenings in peripheral blood mononuclear cells, we depict here a novel expression chart of 678 genes and 84 miRNAs controlling inflammatory, immune and metabolic responses. In order to further elucidate the link between inflammation and the HDL cholesterol pathway in metabolic syndrome (MS), we focused on the regulation of the ATP-binding cassette transporter A1 (ABCA1), a key player in cholesterol efflux...
March 23, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29499204/alteration-in-microrna-25-expression-regulate-cardiac-function-via-renin-secretion
#9
Hongzhi Li, Yeming Xie, Yunshuang Liu, Yali Qi, Chong Tang, Xuefeng Li, Kuiyang Zuo, Dingce Sun, Yongchao Shen, Daxin Pang, Yanhui Chu, Binghai Zhao
Heart failure arises from diverse cardiovascular diseases, including hypertension, ischemic disease and atherosclerosis, valvular insufficiency, myocarditis, and contractile protein mutations. MicroRNAs are dysregulated in heart failure, but identification of the specific microRNAs involved remains incomplete. Here, we evaluate miR-25 expression in the peripheral blood from healthy, dilated cardiomyopathy (DCM), remote infarct (OMI), hypertensive heart disease (HHD), and HHD resulting in heart failure (HHDF) using q-PCR...
April 1, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29479887/niemann-pick-disease-type-c1-gene-expression-in-pbmcs-is-associated-with-interleukin-10-serum-concentration-a-case-control-study
#10
Fatemeh Zali, Maryam Teimouri, Parisa Shabani, Akram Vatannejad, Mahdi Najafi, Hossein Shateri, Mostafa Asadnia, Mahmood Doosti
BACKGROUND: Recent studies showed that atherosclerosis is a lysosomal storage disease (LSD) and Niemann-Pick disease type C1 (NPC1) is the most important protein of the lysosomal membrane that is involved in the removal of FC from lysosomes. Whereas several in vitro and in vivo studies have described the crosstalk between lysosomal cholesterol accumulation and increased inflammation, there is no study addressing the correlation between NPC1 gene expression and an anti-inflammatory cytokine, interleukin 10 (IL-10) serum concentration in atherosclerotic patients...
January 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29420090/lxr%C3%AE-is-expressed-at-higher-levels-in-healthy-people-compared-to-atherosclerosis-patients-and-its-over-expression-polarizes-macrophages-towards-an-anti-inflammatory-m%C3%AE-2-phenotype
#11
Mengyuan Liu, Weijian Yang, Shuling Liu, Duncan Hock, Bohao Zhang, Ruth Ya Huo, Xiaoguang Tong, Hua Yan
OBJECTIVES: (1) To investigate the expression patterns of MΦ1 and MΦ2 phenotype markers of peripheral blood monocyte (PBMC)-derived macrophages in atherosclerosis patients and healthy controls, as well as the expression correlation among these genes. (2) To elucidate whether a high level of liver X receptor α (LXRα) expression is associated with anti-inflammatory MΦ2-type polarization. DESIGN: Peripheral blood monocytes (PBMCs) were obtained from 28 patients with carotid artery plaques and 10 normal persons, who did not have carotid artery plaques...
2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29366786/smad7-methylation-as-a-novel-marker-in-atherosclerosis
#12
Lihua Wei, Shimei Zhao, Gaoxing Wang, Shiming Zhang, Weibo Luo, Zhengxue Qin, Xiongjie Bi, Yimei Tan, Moke Meng, Jun'an Qin, Huiping Qin, Dan Tian, An'wen Zhang
Atherosclerosis is a complicated process comprising inflammation, accumulation of collagen matrix and aberrant DNA methylation. SMAD7 is known to play an important role in fibrosis and inflammation. In recent years, increasing research has concentrated on the connection between DNA methylation and atherosclerosis. The current study was designed to investigate methylation status of some specific gene with a focus on SMAD7 in atherosclerosis and elucidate their relationship. We found that SMAD7 expression was decreased and its promoter region was markedly methylated in atherosclerotic plaques when compared with normal artery walls...
February 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29250154/microrna-24-inhibits-the-proliferation-and-migration-of-endothelial-cells-in-patients-with-atherosclerosis-by-targeting-importin-%C3%AE-3-and-regulating-inflammatory-responses
#13
Ye Zheng, Yongxing Li, Gang Liu, Xiangqian Qi, Xufen Cao
The aim of the present study was to measure the level of microRNA (miRNA or miR)-24 in the serum of patients with atherosclerosis and to investigate the effect of miR-24 on the expression of importin-α3 and tumor necrosis factor (TNF)-α, as well as the proliferation and migration of vascular endothelial cells. A total of 30 patients with atherosclerosis admitted to hospital between January and June 2016 were enrolled in the present study; 30 healthy subjects with a similar age range were enrolled as controls...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29234849/urbanization-in-sub-saharan-africa-declining-rates-of-chronic-and-recurrent-infection-and-their-possible-role-in-the-origins-of-non-communicable-diseases
#14
REVIEW
Stephen W Bickler, Andrew Wang, Said Amin, Jonathan Halbach, Radhames Lizardo, David M Cauvi, Antonio De Maio
BACKGROUND: Non-communicable diseases (NCDs), such as atherosclerosis and cancers, are a leading cause of death worldwide. An important, yet poorly explained epidemiological feature of NCDs is their low incidence in under developed areas of low-income countries and rising rates in urban areas. METHODS: With the goal of better understanding how urbanization increases the incidence of NCDs, we provide an overview of the urbanization process in sub-Saharan Africa, discuss gene expression differences between rural and urban populations, and review the current NCD determinant model...
December 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29207167/prazosin-protects-myocardial-cells-against-anoxia-reoxygenation-injury-via-the-extracellular-signal%C3%A2-regulated-kinase-signaling-pathway
#15
Lixin Wang, Yan Xue, Hao Ma, Haiyan Shi, Ling Wang, Xiaozheng Cui
Ischemic heart disease (including coronary arterial atherosclerosis, or vascular cavity stenosis or occlusion) remains the leading cause of disease‑associated mortality worldwide. Prazosin, a receptor blocker of postsynaptic adrenaline, is essential in expanding peripheral arteries, which decreases peripheral vascular resistance, and regulates anti‑hypertensive action. However, the mechanisms underlying the effects of prazosin have not been fully elucidated. The aim of the present study was to investigate the protective effects of prazosin on myocardial cells against anoxia‑reoxygenation injury in a mouse model...
February 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29176764/interleukin-27-is-increased-in-carotid-atherosclerosis-and-promotes-nlrp3-inflammasome-activation
#16
Ida Gregersen, Øystein Sandanger, Erik T Askevold, Ellen Lund Sagen, Kuan Yang, Sverre Holm, Turid M Pedersen, Mona Skjelland, Kirsten Krohg-Sørensen, Trond Vidar Hansen, Tuva Børresdatter Dahl, Kari Otterdal, Terje Espevik, Pål Aukrust, Arne Yndestad, Bente Halvorsen
AIM: Interleukin-27 (IL-27) is involved in different inflammatory diseases; however, its role in atherosclerosis is unclear. In this study we investigated the expression of IL-27 and its receptor in patients with carotid atherosclerosis and if IL-27 could modulate the inflammatory effects of the NLRP3 inflammasome in vitro. METHODS: Plasma IL-27 was measured by enzyme immunoassay in patients with carotid stenosis (n = 140) and in healthy controls (n = 19). Expression of IL-27 and IL-27R was analyzed by quantitative PCR and immunohistochemistry in plaques from patients and in non-atherosclerotic vessels...
2017: PloS One
https://www.readbyqxmd.com/read/29153655/clinical-evidence-supports-a-protective-role-for-cxcl5-in-coronary-artery-disease
#17
Saranya Ravi, Robert N Schuck, Eleanor Hilliard, Craig R Lee, Xuming Dai, Kaitlin Lenhart, Monte S Willis, Brian C Jensen, George A Stouffer, Cam Patterson, Jonathan C Schisler
Our goal was to measure the association of CXCL5 and molecular phenotypes associated with coronary atherosclerosis severity in patients at least 65 years old. CXCL5 is classically defined as a proinflammatory chemokine, but its role in chronic inflammatory diseases, such as coronary atherosclerosis, is not well defined. We enrolled individuals who were at least 65 years old and undergoing diagnostic cardiac catheterization. Coronary artery disease (CAD) severity was quantified in each subject via coronary angiography by calculating a CAD score...
December 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29151033/induction-of-dendritic-cell-mediated-activation-of-t-cells-from-atherosclerotic-plaques-by-human-heat-shock-protein-60
#18
Mizanur Rahman, Johnny Steuer, Peter Gillgren, Assim Hayderi, Anquan Liu, Johan Frostegård
BACKGROUND: Atherosclerosis is characterized by the presence of activated immune-competent cells including dendritic cells (DCs) and T cells, dead cells, and oxidized low-density lipoprotein. HSP60 (Heat shock protein 60) has been implicated in atherosclerosis. A plasma protein, Annexin A5, has atheroprotective properties. METHODS AND RESULTS: Human DCs differentiated from peripheral blood monocytes were treated with human HSP60 or HSP90 and autologous T cells were cocultured with these pretreated DCs (mDCs)...
November 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29096828/analysis-of-circulating-mirnas-in-patients-with-familial-hypercholesterolaemia-treated-by-ldl-lp-a-apheresis
#19
Dana Dlouha, Milan Blaha, Vladimir Blaha, Ilona Fatorova, Jaroslav A Hubacek, Petr Stavek, Vera Lanska, Alena Parikova, Jan Pitha
BACKGROUND: LDL/Lp(a) apheresis therapy is a well-established method of aggressively lowering LDL and Lp(a). Recently, miRNAs have been discussed as markers of vascular status including atherosclerosis. MiRNAs inhibit post-transcriptional processes through RNA duplex formation resulting in gene silencing or regulation of gene expression. MATERIALS AND METHODS: We measured a profile of 175 plasma-circulating miRNAs using pre-defined Serum/Plasma Focus Human microRNA PCR Panels in pooled samples of 11 subjects with familial hypercholesterolaemia under long-term apheresis treatment...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29017439/the-expression-of-pdcd4-in-patients-with-missed-abortion-and-its-clinical-significance
#20
Yue Li, Xihong Liu, Yingshun Sun, Yanping Liu, Lu Wan, Lining Zhang, Zhenghui Fang, Zengtao Wei, Xiaoyan Wang
Missed abortion is a special form of spontaneous abortion and its incidence shows a rising trend. Immunological factor is one of the most common reasons. Tumor suppressor gene programmed cell death 4 ( PDCD4) also participates in some immune-mediated inflammation, such as atherosclerosis, and so on, but the role of PDCD4 in missed abortion remains unclear. Here, the expression of PDCD4 was detected in decidual and chorionic tissues, as well as peripheral blood mononuclear cells from patients with missed abortion and healthy controls using quantitative real-time polymerase chain reaction (qRT-PCR), Western blot, and immunohistochemistry...
November 2017: Reproductive Sciences
keyword
keyword
63597
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"