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Stressors in vitro parkinsons disease model

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https://www.readbyqxmd.com/read/27073388/neuroprotective-role-of-val-8-glp-1-glu-pal-in-an-in-vitro-model-of-parkinson-s-disease
#1
Lin Li, Ke Liu, Juan Zhao, Christian Holscher, Guang-Lai Li, Yue-Ze Liu
The growth factor glucagon-like peptide-1 (GLP-1) is neuroprotective in several animal models of neurodegeneration. Here, we analyzed the neuroprotective effects of a novel protease-resistant GLP-1 analogue, (Val(8))GLP-1-Glu-PAL, which has advantages over older analogues, such as improvement of hippocampal neurogenesis, glucose homeostasis, and insulin secretion. We established an in vitro model of Parkinson's disease using the mitochondrial stressor rotenone in primary cultured mouse neurons pretreated with (Val(8))GLP-1-Glu-PAL...
February 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/21067438/bifunctional-phenolic-choline-conjugates-as-anti-oxidants-and-acetylcholinesterase-inhibitors
#2
Jaroslav Sebestík, Sérgio M Marques, Pedro L Falé, Susana Santos, Daniela M Arduíno, Sandra M Cardoso, Catarina R Oliveira, M Luísa M Serralheiro, M Amélia Santos
Because of the complex cascade of molecular events that can occur in the brain of an Alzheimer's disease (AD) patient, the therapy of this neurodegenerative disease seems more likely to be achieved by multifunctional drugs. Herein, a new series of dual-targeting ligands have been developed and in vitro bioevaluated. Their architecture is based on conjugating the acetylcholinesterase inhibition and anti-oxidant properties in one molecular entity. Specifically, a series of naturally occurring phenolic acids with recognized anti-oxidant properties (derivatives of caffeic acid, rosmarinic acid, and trolox) have been conjugated with choline to account for the recognition by acetylcholinesterase (AChE)...
August 2011: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/20007772/functional-enhancement-and-protection-of-dopaminergic-terminals-by-rab3b-overexpression
#3
Chee Yeun Chung, James B Koprich, Penelope J Hallett, Ole Isacson
In Parkinson's disease (PD), dopaminergic (DA) neurons in the substantia nigra (SN, A9) are particularly vulnerable, compared to adjacent DA neurons within the ventral tegmental area (VTA, A10). Here, we show that in rat and human, one RAB3 isoform, RAB3B, has higher expression levels in A10 compared to A9 neurons. RAB3 is a monomeric GTPase protein that is highly enriched in synaptic vesicles and is involved in synaptic vesicle trafficking and synaptic transmission, disturbances of which have been implicated in several neurodegenerative diseases, including PD...
December 29, 2009: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/18355641/differences-between-normal-and-alpha-synuclein-overexpressing-sh-sy5y-neuroblastoma-cells-after-abeta-1-42-and-nac-treatment
#4
COMPARATIVE STUDY
Akos Hunya, István Földi, Viktor Szegedi, Katalin Soós, Márta Zarándi, Antal Szabó, Dénes Zádori, Botond Penke, Zsolt L Datki
Alpha-synuclein (alphaSN) plays a major role in numerous neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. Intracellular inclusions containing aggregated alphaSN have been reported in Alzheimer's and Parkinson's affected brains. Moreover, a proteolytic fragment of alphaSN, the so-called non-amyloid component of Alzheimer's disease amyloid (NAC) was found to be an integral part of Alzheimer's dementia related plaques. Despite the extensive research on this topic, the exact toxic mechanism of alphaSN remains elusive...
March 28, 2008: Brain Research Bulletin
https://www.readbyqxmd.com/read/17558391/-rejuvenation-protects-neurons-in-mouse-models-of-parkinson-s-disease
#5
C Savio Chan, Jaime N Guzman, Ema Ilijic, Jeff N Mercer, Caroline Rick, Tatiana Tkatch, Gloria E Meredith, D James Surmeier
Why dopamine-containing neurons of the brain's substantia nigra pars compacta die in Parkinson's disease has been an enduring mystery. Our studies suggest that the unusual reliance of these neurons on L-type Ca(v)1.3 Ca2+ channels to drive their maintained, rhythmic pacemaking renders them vulnerable to stressors thought to contribute to disease progression. The reliance on these channels increases with age, as juvenile dopamine-containing neurons in the substantia nigra pars compacta use pacemaking mechanisms common to neurons not affected in Parkinson's disease...
June 28, 2007: Nature
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