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Proteus Biomedical

Manikandan Dhayalan, Michael Immanuel Jesse Denison, Manikandan Ayyar, N N Gandhi, Kathiravan Krishnan, Baykal Abdulhadi
In modern era, the great interest and demand among chemists and researchers for metal nanoparticles is increasing in the application of biomedical fields, textiles, cosmetics and various sectors. Consequently, the present study reports an eco-friendly, cost-effective, rapid and easy method to produce environment-friendly metal nanoparticles to prevent exhaustion of metal resources. In this context, gold and silver metal nanoparticles were green synthesized using the Root Extract of Coleous forskohlii (RECo) as capping and reducing agent...
May 1, 2018: Journal of Photochemistry and Photobiology. B, Biology
Muthukumar Abinaya, Baskaralingam Vaseeharan, Mani Divya, Sekar Vijayakumar, Marimuthu Govindarajan, Naiyf S Alharbi, Jamal M Khaled, Mohammed N Al-Anbr, Giovanni Benelli
Microbial polysaccharides produced by marine species play a key role in food and cosmetic industry, as they are nontoxic and biodegradable polymers. This investigation reports the isolation of exopolysaccharide from Bacillus licheniformis Dahb1 and its biomedical applications. Bacillus licheniformis Dahb1 exopolysaccharide (Bl-EPS) was extracted using the ethanol precipitation method and structurally characterized. FTIR and 1 H-NMR pointed out the presence of various functional groups and primary aromatic compounds, respectively...
April 27, 2018: Environmental Science and Pollution Research International
Gowri S, Gopinath K, Arumugam A
The present study reports the biogenic synthesis of Cadmium Oxide Nanoparticles (CdO NPs) using plant pathogenic fungus Nigrospora oryzae culture filtrate. Further, the effect of the NPs on the cancer cell line (HeLa) is explored. The sample was characterized using Thermogravimetric/Differential Thermal (TG/DTA), Powder X-ray Diffraction (XRD), X-ray Photoelectron spectroscopy (XPS), UV-Visible Diffuse Reflectance Spectroscopy (UV-DRS), Field Emission Transmission Electron Microscopy (FE-SEM) with Energy Dispersive X-ray Spectroscopy (EDX), High Resolution Transmission Electron Microscopy (HR-TEM) and Selected Area Electron Diffraction (SAED) analysis...
March 2018: Journal of Photochemistry and Photobiology. B, Biology
Rajagopalan Thaya, Baskaralingam Vaseeharan, Jeyachandran Sivakamavalli, Arokiadhas Iswarya, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Mohammed N Al-Anbr, Jamal M Khaled, Giovanni Benelli
The successful treatment of multi-drug resistant microbial pathogens represents a major challenge for public health management. Here, chitosan-alginate (CS/ALG) microspheres with narrow size distribution were fabricated by ionically cross linking method using Ca2+ ions as agents for polymer solidification. The physicochemical properties of CS/ALG microspheres, such as surface morphology and size, were studied by SEM. The functional group interactions were confirmed by Fourier transform infrared (FTIR) spectroscopy...
January 2018: Microbial Pathogenesis
Yaqi Wo, Zi Li, Alessandro Colletta, Jianfeng Wu, Chuanwu Xi, Adam J Matzger, Elizabeth J Brisbois, Robert H Bartlett, Mark E Meyerhoff
Stable and long-term nitric oxide (NO) releasing polymeric materials have many potential biomedical applications. Herein, we report the real-time observation of the crystallization process of the NO donor, S-nitroso-N-acetylpenicillamine (SNAP), within a thermoplastic silicone-polycarbonate-urethane biomedical polymer, CarboSil 20 80A. It is demonstrated that the NO release rate from this composite material is directly correlated with the surface area that the CarboSil polymer film is exposed to when in contact with aqueous solution...
July 15, 2017: Composites. Part B, Engineering
Karthika Prasad, G S Lekshmi, Kola Ostrikov, Vanessa Lussini, James Blinco, Mandhakini Mohandas, Krasimir Vasilev, Steven Bottle, Kateryna Bazaka, Kostya Ostrikov
Reduced graphene oxide (rGO) is a promising antibacterial material, the efficacy of which can be further enhanced by the addition of silver nanoparticles (nAg). In this study, the mechanisms of antibacterial activity of rGO-nAg nanocomposite against several important human pathogenic multi-drug resistant bacteria, namely Gram-positive coccal Staphylococcus aureus and Gram-negative rod-shaped Escherichia coli and Proteus mirabilis are investigated. At the same concentration (100 µg/ml), rGO-nAg nanocomposite was significantly more effective against all three pathogens than either rGO or nAg...
May 8, 2017: Scientific Reports
Nicole Canales, Iván Montenegro, Mario Párraga, Yusser Olguín, Patricio Godoy, Enrique Werner, Alejandro Madrid
Embothrium coccineum J.R. Forst. & G. Forst is an evergreen tree that has been used as a folk remedy for the treatment of neuralgia, tooth pains, wound healing, and glandular conditions, as well as an antiseptic agent against bacterial infection. The antibacterial activities of sequential extracts (hexane, dichloromethane, ethyl acetate, and ethanol) from the leaves of E. coccineum were evaluated by means of the micro-dilution assay against six (Escherichia coli; Klebsiella pneumoniae; Proteus mirabilis; Pseudomonas aeruginosa; Staphylococcus aureus and Streptococcus pyogenes) multiresistant bacteria strains...
October 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
M S Kumar, S Ghosh, S Nayak, A P Das
Urinary tract infections (UTIs) are potentially life threatening infections that are associated with high rates of incidence, recurrence and mortality. UTIs are characterized by several chronic infections which may lead to lethal consequences if left undiagnosed and untreated. The uropathogens are consistent across the globe. The most prevalent uropathogenic gram negative bacteria are Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumonia. Early detection and precise diagnosis of these infections will play a pivotal role in health care, pharmacological and biomedical sectors...
June 15, 2016: Biosensors & Bioelectronics
Feng Tang, Dai-Wen Pang, Zhi Chen, Jian-Bo Shao, Ling-Hong Xiong, Yan-Ping Xiang, Yan Xiong, Kai Wu, Hong-Wu Ai, Hui Zhang, Xiao-Li Zheng, Jing-Rui Lv, Wei-Yong Liu, Hong-Bing Hu, Hong Mei, Zhen Zhang, Hong Sun, Yun Xiang, Zi-Yong Sun
It is a great challenge in nanotechnology for fluorescent nanobioprobes to be applied to visually detect and directly isolate pathogens in situ. A novel and visual immunosensor technique for efficient detection and isolation of Salmonella was established here by applying fluorescent nanobioprobes on a specially-designed cellulose-based swab (a solid-phase enrichment system). The selective and chromogenic medium used on this swab can achieve the ultrasensitive amplification of target bacteria and form chromogenic colonies in situ based on a simple biochemical reaction...
February 28, 2016: Nanoscale
Alessandro Colletta, Jianfeng Wu, Yaqi Wo, Michael Kappler, Hao Chen, Chuanwu Xi, Mark E Meyerhoff
Urinary Foley catheters are utilized for management of hospitalized patients and are associated with high rates of urinary tract infections (UTIs). Nitric oxide (NO) potently inhibits microbial biofilm formation, which is the primary cause of catheter associated UTIs (CAUTIs). Herein, commercial silicone Foley catheters are impregnated via a solvent swelling method with S-nitroso-N-acetyl-D-penicillamine (SNAP), a synthetic NO donor that exhibits long-term NO release and stability when incorporated into low water-uptake polymers...
June 8, 2015: ACS Biomaterials Science & Engineering
Sukhwinder K Bhullar, Burcak Kaya Özsel, Ramesh Yadav, Ginpreet Kaur, Meena Chintamaneni, Harpal S Buttar
BACKGROUND: Fibrous structures and synthetic polymer blends offer potential usages in making biomedical devices, textiles used in medical practices, food packaging, tissue engineering, environmental applications and biomedical arena. These products are also excellent candidates for building scaffolds to grow stem cells for implantation, to make tissue engineering grafts, to make stents to open up blood vessels caused by atherosclerosis or narrowed by blood clots, for drug delivery systems for micro- to nano-medicines, for transdermal patches, and for healing of wounds and burn care...
December 2015: Journal of Complementary & Integrative Medicine
Yuri Savelyev, Vitali Veselov, Ludmila Markovskaya, Olga Savelyeva, Elena Akhranovich, Natalya Galatenko, Ludmila Robota, Tamara Travinskaya
Biologically active polyurethane foams are the fast-developed alternative to many applications of biomedical materials. Due to the polyurethane structure features and foam technology it is possible to incorporate into their structure the biologically active compounds of target purpose via structural-chemical modification of macromolecule. A series of new biologically active polyurethane foams (PUFs) was synthesized with polyethers (MM 2500-5000), polyesters MM (500-2200), 2,4(2,6) toluene diisocyanate, water as a foaming agent, catalysts, foam stabilizers and functional compounds...
December 2014: Materials Science & Engineering. C, Materials for Biological Applications
Hemant Shah, Raymond D Allard, Robert Enberg, Ganesh Krishnan, Patricia Williams, Prakash M Nadkarni
BACKGROUND: A large body of work in the clinical guidelines field has identified requirements for guideline systems, but there are formidable challenges in translating such requirements into production-quality systems that can be used in routine patient care. Detailed analysis of requirements from an implementation perspective can be useful in helping define sub-requirements to the point where they are implementable. Further, additional requirements emerge as a result of such analysis...
2012: BMC Medical Informatics and Decision Making
Elizabeth F McInnes, Lorna Rasmussen, Peony Fung, Amanda M Auld, Luisana Alvarez, David A Lawrence, Morgan E Quinn, Tammy D Utteridge, Gloria M del Fierro, Bianca A Vassallo, Robert Stevenson
Viral, bacterial and parasitological infections in rats and mice used in biomedical research continue to occur despite improved housing and biosurveillance. The presence of disease in laboratory animals can lead to spurious results for research undertaken in universities, research institutes and the pharmaceutical industry. Here the authors report the results of serological, microbiological, parasitological and molecular tests done on mice and rats from Australasia submitted to a rodent health monitoring laboratory (Cerberus Sciences) from 2004 to 2009...
2011: Lab Animal
Rong Wang, Koon Gee Neoh, Zhilong Shi, En-Tang Kang, Paul Anantharajah Tambyah, Edmund Chiong
Silicone has been utilized extensively for biomedical devices due to its excellent biocompatibility and biodurability properties. However, its surface is easily colonized by bacteria which will increase the probability of nosocomial infection. In the present work, a hydrophilic antimicrobial carboxymethyl chitosan (CMCS) layer has been grafted on medical grade silicone surface pre-treated with polydopamine (PDA). The increase in hydrophilicity was confirmed from contact angle measurement. Bacterial adhesion tests showed that the PDA-CMCS coating reduced the adhesion of Escherichia coli and Proteus mirabilis by ≥ 90%...
February 2012: Biotechnology and Bioengineering
Zongshun Lu, Tianhong Dai, Liyi Huang, Divya B Kurup, George P Tegos, Ashlee Jahnke, Tim Wharton, Michael R Hamblin
AIMS: Fullerenes are under intensive study for potential biomedical applications. We have previously reported that a C60 fullerene functionalized with three dimethylpyrrolidinium groups (BF6) is a highly active broad-spectrum antimicrobial photosensitizer in vitro when combined with white-light illumination. We asked whether this high degree of in vitro activity would translate into an in vivo therapeutic effect in two potentially lethal mouse models of infected wounds. MATERIALS & METHODS: We used stable bioluminescent bacteria and a low light imaging system to follow the progress of the infection noninvasively in real time...
December 2010: Nanomedicine
Jesus L Naldo, Nelson L Libanan, Jaime H Samour
A study was conducted to determine the health status of the free-living spiny-tailed lizard (Uromastyx spp.) population at Wrsan, Al Ajban, Abu Dhabi, United Arab Emirates. A total of 90 spiny-tailed lizards, 61 males and 29 females, were examined from June to August 2006. Mean body weights were 1,564.4 g and 809.4 g for males and females, respectively. Mean body lengths were 62.1 cm and 49.4 cm for males and females, respectively. Fourteen lizards were found with abnormalities including abscesses, bite wounds, and deformed or missing tail ends, digits, or claws...
September 2009: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
John P A Ioannidis
The credibility and replication of research findings evolve over time, as data accumulate. However, translation of postulated research promises to real-life biomedical applications is uncommon. In some fields of research, we may observe diminishing effects for the strength of research findings and rapid alternations of exaggerated claims and extreme contradictions--the "Proteus Phenomenon." While these phenomena are probably more prominent in the basic sciences, similar manifestations have been documented even in clinical trials and they may undermine the credibility of clinical research...
2006: PLoS Clinical Trials
M Cannataro, G Cuda, P Veltri
OBJECTIVES: Biomedical applications, such as analysis and management of mass spectrometry proteomics experiments, involve heterogeneous platforms and knowledge, massive data sets, and complex algorithms. Main requirements of such applications are semantic modeling of the experiments and data analysis, as well as high performance computational platforms. In this paper we propose a software platform allowing to model and execute biomedical applications on the Grid. METHODS: Computational Grids offer the required computational power, whereas ontologies and workflow help to face the heterogeneity of biomedical applications...
2005: Methods of Information in Medicine
Vikas Prabhakar, Ishan Capila, Carlos J Bosques, Kevin Pojasek, Ram Sasisekharan
GalAGs (galactosaminoglycans) are one subset of the GAG (glycosaminoglycan) family of chemically heterogeneous polysaccharides that are involved in a wide range of biological processes. These complex biomacromolecules are believed to be responsible for the inhibition of nerve regeneration following injury to the central nervous system. The enzymic degradation of GAG chains in damaged nervous tissue by cABC I (chondroitinase ABC I), a broad-specificity lyase that degrades GalAGs, promotes neural recovery. In the present paper, we report the subcloning of cABC I from Proteus vulgaris, and discuss a simple methodology for the recombinant expression and purification of this enzyme...
February 15, 2005: Biochemical Journal
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