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JOURNAL ARTICLE
Veera Kankainen, Anu Katainen, Lotta Hautamäki, Katariina Warpenius
BACKGROUND: A growing body of research has analysed the representations of alcohol and other drugs (AOD) in policy-making, but few studies have focused on the representations reproduced in law-making processes, especially in the context of the regulation of the rights of social and health care service users. This study examined what kind of representations of AOD use are reproduced in the legislative reform of social and health care service users' rights in Finland. The purpose of the reform is to strengthen social and health care service users' rights to self-determination and to reduce the use of restrictive measures...
May 3, 2024: International Journal on Drug Policy
#22
JOURNAL ARTICLE
Karnchanok Kaimuangpak, Reny Rosalina, Kanjana Thumanu, Natthida Weerapreeyakul
Plant-derived bioactive macromolecules (i.e., proteins, lipids, and nucleic acids) were prepared as extracellular vesicles (EVs). Plant-derived EVs are gaining pharmaceutical research interest because of their bioactive components and delivery properties. The spherical nanosized EVs derived from Raphanus sativus L. var. caudatus Alef microgreens previously showed antiproliferative activity in HCT116 colon cancer cells from macromolecular compositions (predominantly proteins). To understand the mechanism of action, the biological activity studies, i...
May 1, 2024: International Journal of Biological Macromolecules
#23
JOURNAL ARTICLE
Jie Zhang, Zeqing Long, Qiuwen Wang, Yilin Dong, Guangming Zhang
Both ultrasound and sludge retention time (SRT) enable the in-situ sludge reduction during wastewater treatment, but the influence of SRT on ultrasonic lysis - cryptic growth is unclear. This paper researched the influence of different SRTs on sludge lysis - cryptic growth using a sequential bio-reactor (SBR), then explained in details the changes of microorganisms in the SBR. The best SRT for sludge reduction was 30 d, and 47.29% reduction in sludge was achieved. The different SRTs changed the organic matter removal in the wastewater, and the removal rate decreased when SRT exceeded 60 d...
May 1, 2024: Environmental Research
#24
JOURNAL ARTICLE
Francisco Matos, Fernando Castanheira, Mário Barroso, Mónica Antunes, João Franco, Suzana Fonseca
Pesticides play an important role in forensic toxicology and are usually classified as a single class of chemicals. Despite their commonly perceived unity, pesticides encompass a spectrum of compounds, including organophosphates, carbamates, pyrethroids or organochlorines, among others, each with varying degrees of toxicity. Pesticide analysis in post-mortem samples can be difficult due to the complexity of the samples and to the high toxicity of these compounds. The aim of this study was to develop and validate an easy to use, sensitive, and robust method, using ultra-performance liquid chromatography-tandem mass spectrometry to be incorporated in the routine flow for pesticide analysis in post-mortem blood samples...
April 23, 2024: Journal of Pharmaceutical and Biomedical Analysis
#25
JOURNAL ARTICLE
Guilherme Vilela-Alves, Rita Rebelo Manuel, Neide Pedrosa, Inês A Cardoso Pereira, Maria João Romão, Cristiano Mota
Molybdenum- or tungsten-dependent formate dehydrogenases have emerged as significant catalysts for the chemical reduction of CO2 to formate, with biotechnological applications envisaged in climate-change mitigation. The role of Met405 in the active site of Desulfovibrio vulgaris formate dehydrogenase AB (DvFdhAB) has remained elusive. However, its proximity to the metal site and the conformational change that it undergoes between the resting and active forms suggests a functional role. In this work, the M405S variant was engineered, which allowed the active-site geometry in the absence of methionine Sδ interactions with the metal site to be revealed and the role of Met405 in catalysis to be probed...
May 1, 2024: Acta Crystallographica. Section F, Structural Biology Communications
#26
JOURNAL ARTICLE
Sabitha Venkateswaran, Ranganathan Thirumalai
BACKGROUND: Alcohol Dependence Syndrome is a chronic illness that is relapsing in nature. Past research has shown that coping strategies that are specific to alcohol dependence are useful in preventing long-term relapse. This follow-up study is, therefore, an attempt to understand the coping styles and strategies that are associated with relapse among individuals dependent on alcohol. METHODS: We aimed to cross-sectionally assess the severity of alcohol dependence and coping styles of Alcohol dependent individuals...
May 2024: Indian Journal of Psychological Medicine
#27
JOURNAL ARTICLE
Cornel Sava, Dana-Adriana Iluţiu-Varvara, Roxana Mare, Marius Daniel Roman, Simona Rada, Elena Maria Pică, Lorentz Jäntschi
Nowadays, the challenge is to transform dehydrated sewage sludge resulting from wastewater treatment plants from waste into resource. Following this objective, the sludge was further dried and submitted to X-ray diffraction (XRD) and FTIR analysis. The sludge was first dried in ventilated and unventilated spaces at 50 ∘ C and 100 ∘ C, for 60 and 100 minutes (min) in each case. The final mass and evaporation degree of the sludge depends on the initial mass, ventilation type, drying time, and temperature...
April 30, 2024: Heliyon
#28
JOURNAL ARTICLE
Junko Okano, Takahiko Nakagawa, Hideto Kojima
Bone marrow-derived cells (BMDCs) are heterogeneous populations in which not only pluripotent stem cells, namely, hematopoietic stem cells (HSCs), mesenchymal stem cells (MSC) but also endothelial progenitor cells (EPC) are involved. BMDCs contribute to the maintenance of homeostasis and recovery from disrupted homeostasis as the immune, endocrine, and nervous systems. The skin is the largest organ in which various tissues, such as the epidermis, dermis, skin appendages (i.e., hair follicles), fats, muscles, and vessels, are tightly and systematically packed...
2024: Frontiers in Physiology
#29
Alex Yartsev, Amelia Scott
We present the extraordinary circumstance of a female patient in her sixties who suffered a massive lignocaine overdose while undergoing treatment with Veno-Arterial Extracorporeal Membrane Oxygenation (VA ECMO) following an emergency coronary artery bypass graft (CABG). The patient was initially admitted to the Intensive Care Unit (ICU) due to unstable angina and a history of insulin-dependent type two diabetes mellitus, hypertension, hypercholesterolemia, carotid artery stenosis, and an extensive smoking history...
June 2024: Toxicology Reports
#30
JOURNAL ARTICLE
Jing Wang, Chenlin Lu, Xuemei Shen, Taibo He, Diannan Lu, Xiaoyan Wang, Yuan Zhang, Zhanglin Lin, Xiaofeng Yang
D-allulose, a highly desirable sugar substitute, is primarily produced using the D-allulose 3-epimerase (DAE). However, the availability of usable DAE enzymes is limited. In this study, we discovered and engineered a novel DAE Rum55, derived from a human gut bacterium Ruminococcus sp. CAG55. The activity of Rum55 was strictly dependent on the presence of Co2+ , and it exhibited an equilibrium conversion rate of 30.6 % and a half-life of 4.5 h at 50 °C. To enhance its performance, we engineered the interface interaction of Rum55 to stabilize its tetramer structure, and the best variant E268R was then attached with a self-assembling peptide to form active enzyme aggregates as carrier-free immobilization...
April 30, 2024: International Journal of Biological Macromolecules
#31
JOURNAL ARTICLE
Hui Liu, Yubing Zhou, Mangaladoss Fredimoses, Peijia Niu, Yunxiao Ge, Rui Wu, Tingting Liu, Pan Li, Yang Shi, Yaqian Shi, Kangdong Liu, Zigang Dong
JAK2/STAT3/MYC axis is dysregulated in nearly 70 % of human cancers, but targeting this pathway therapeutically remains a big challenge in cancer therapy. In this study, genes associated with JAK2, STAT3, and MYC were analyzed, and potential target genes were selected. Leucine-rich PPR motif-containing protein (LRPPRC) whose function and regulation are not fully understood, emerged as one of top 3 genes in terms of RNA epigenetic modification. Here, we demonstrate LRPPRC may be an independent prognostic indicator besides JAK2, STAT3, and MYC...
April 30, 2024: International Journal of Biological Macromolecules
#32
JOURNAL ARTICLE
Mohamed Elsheref, Xian Cao, Matthew A Tarr
Aldehyde and ketone oxocarboxylic acid photoproducts were semi-quantitated in the aqueous phase after subjecting Macondo (MC252) crude oil-seawater systems to simulated solar irradiation. Electrospray ionization tandem mass spectrometry (ESI-MS/MS) was applied after derivatizing the samples with 2,4-dinitrophenylhydrazine (DNPH). Oil-seawater was irradiated at 27.0 °C using a solar simulator for 1 to 18 h. Following irradiation, the aqueous phase was treated with DNPH to generate aldehyde-DNPH and ketone-DNPH derivatives...
April 26, 2024: Journal of Hazardous Materials
#33
JOURNAL ARTICLE
Lina Lantz, Zheng Chang, Suvi Virtanen
BACKGROUND: Substance use disorders are highly prevalent in people within the criminal justice system. Psychological programs are the most common type of treatment available and have been shown to decrease recidivism, but dropping out of treatment is common. Risk factors associated with treatment dropout remain unclear in this setting, and whether the risk factors differ by treatment form (group-based vs. individual). METHODS: Outcome (treatment dropout) was defined as not finishing the program due to client's own wish, misbehavior, no-shows, or because program leader found client to be unsuitable...
April 26, 2024: Drug and Alcohol Dependence
#34
JOURNAL ARTICLE
Pratik S Gotad, Calum Bochenek, Chrys Wesdemiotis, Sadhan C Jana
Per- and polyfluoroalkyl substances are an emerging class of contaminants that are environmentally persistent, bioaccumulative, and noxious to human health. Among these, perfluorooctanoic acid (PFOA) molecules are widely found in ground and surface water sources. A novel high surface area, meso- and macroporous syndiotactic polystyrene (sPS) wet gel is used in this work as the adsorbent of PFOA molecules from water at environmentally relevant PFOA concentrations (≤1 μg/L) and cleanse water to below the U...
May 2, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
#35
JOURNAL ARTICLE
Katherine E Burdick, Caitlin E Millett, Anastasia K Yocum, Cara M Altimus, Ole A Andreassen, Valerie Aubin, Raoul Belzeaux, Michael Berk, Joanna M Biernacka, Hilary P Blumberg, Anthony J Cleare, Claudia Diaz-Byrd, Caroline Dubertret, Bruno Etain, Lisa T Eyler, Brent P Forester, Janice M Fullerton, Mark A Frye, Sébastien Gard, Ophelia Godin, Emmanuel Haffen, Federica Klaus, Trine Vik Lagerberg, Marion Leboyer, Anabel Martinez-Aran, Susan McElroy, Philip B Mitchell, Emilie Olie, Phebe Olorunfemi, Christine Passerieux, Amy T Peters, Daniel L Pham, Mircea Polosan, Julia R Potter, Martha Sajatovic, Ludovic Samalin, Raymund Schwan, Megan Shanahan, Brisa Solé, Rebecca Strawbridge, Amanda L Stuart, Ivan Torres, Torrill Ueland, Eduard Vieta, Lana J Williams, Anna L Wrobel, Lakshmi N Yatham, Allan H Young, Andrew A Nierenberg, Melvin G McInnis
OBJECTIVES: Persistent functional impairment is common in bipolar disorder (BD) and is influenced by a number of demographic, clinical, and cognitive features. The goal of this project was to estimate and compare the influence of key factors on community function in multiple cohorts of well-characterized samples of individuals with BD. METHODS: Thirteen cohorts from 7 countries included n = 5882 individuals with BD across multiple sites. The statistical approach consisted of a systematic uniform application of analyses across sites...
October 2023: Focus: Journal of Life Long Learning in Psychiatry
#36
JOURNAL ARTICLE
J Fuchshuber, H Schöber, M Wohlmuth, H Senra, C Rominger, A Schwerdtfeger, H F Unterrainer
BACKGROUND: Although there is a very high comorbidity between tobacco dependence and other addictive disorders, there are only few studies examining the implementation and outcomes of a tobacco cessation program in patients with addictive diseases. Therefore, the aim of this study is to investigate to what extent a standardized tobacco cessation program leads to improvements regarding psychological/physical parameters in patients with addiction undergoing therapy and whether there is a reduction in tobacco consumption...
May 1, 2024: BMC Medicine
#37
JOURNAL ARTICLE
Ming-Yue Bao, Chen-Yu Feng, Xiu-Qing Li, Yan He, Bing Han, Ya-Na Yang, Yuan Zhang, Xing Li
This study aims to identify FDA-approved drugs that can target the kappa-opioid receptor (KOR) for the treatment of demyelinating diseases. Demyelinating diseases are characterized by myelin sheath destruction or formation that results in severe neurological dysfunction. Remission of this disease is largely dependent on the differentiation of oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes (OLGs) in demyelinating lesions. KOR is an important regulatory protein and drug target for the treatment of demyelinating diseases...
April 29, 2024: International Journal of Biological Macromolecules
#38
JOURNAL ARTICLE
Ben Tscharke, Michael Livingston, Jake W O'Brien, Richard Bade, Kevin V Thomas, Jochen F Mueller, Wayne Hall, Bradley S Simpson, Emma Jaunay, Cobus Gerber, Jason M White, Phong K Thai
BACKGROUND: Wastewater analysis provides a complementary measure of alcohol use in whole communities. We assessed absolute differences and temporal trends in alcohol consumption by degree of remoteness and socioeconomics indicators in Australia from 2016 to 2023. METHODS: Alcohol consumption estimates from 50 wastewater treatment plants (WWTP) in the Australian National Wastewater Drug Monitoring Program were used. Trends were analysed based on 1) site remoteness: Major Cities, Inner Regional and a combined remoteness category of Outer Regional and Remote, and 2) using two socioeconomic indexes from the Australian Bureau of Statistics (ABS) relating to advantage and disadvantage for Income, education, occupation, and housing...
April 26, 2024: Drug and Alcohol Dependence
#39
JOURNAL ARTICLE
William H Eger, Daniela Abramovitz, Angela R Bazzi, Annick Bórquez, Carlos F Vera, Alicia Harvey-Vera, Joseph R Friedman, Steffanie A Strathdee
BACKGROUND: Amidst an increasingly toxic drug supply in North America, people who inject drugs may be transitioning to smoking them. We aimed to assess changes in injecting and smoking opioids and methamphetamine among a cohort of people who inject drugs from San Diego, California. METHODS: Over five six-month periods spanning October 2020-April 2023, we assessed prevalence of injecting and smoking opioids or methamphetamine and whether participants used these drugs more frequently by smoking than injecting...
April 26, 2024: Drug and Alcohol Dependence
#40
JOURNAL ARTICLE
Simon D'Aquino, Akaash Kumar, Benjamin Riordan, Sarah Callinan
OBJECTIVE: Despite the high prevalence and comorbidity of alcohol consumption and anxiety, it is unclear whether alcohol consumption influences long-term anxiety. This study aimed to systematically review the literature on the long-term longitudinal effects of alcohol consumption on anxiety in adults. METHODS: EMBASE, PsychInfo, Medline, and Web of Science databases were systematically searched from inception to April 12th, 2024. Articles analysing the relationship between alcohol consumption and anxiety symptoms or anxiety disorder diagnosis at least three-months later in adults were eligible...
April 28, 2024: Addictive Behaviors
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