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https://www.readbyqxmd.com/read/28330312/isolation-and-screening-of-l-asparaginase-free-of-glutaminase-and-urease-from-fungal-sp
#1
Kruthi Doriya, Devarai Santhosh Kumar
L-Asparaginase is a chemotherapeutic drug used in the treatment of acute lymphoblastic leukaemia (ALL), a malignant disorder in children. L-Asparaginase helps in removing acrylamide found in fried and baked foods that is carcinogenic in nature. L-Asparaginase is present in plants, animals and microbes. Various microorganisms such as bacteria, yeast and fungi are generally used for the production of L-asparaginase as it is difficult to obtain the same from plants and animals. L-Asparaginase from bacteria causes anaphylaxis and other abnormal sensitive reactions due to low specificity to asparagine...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330165/genetic-characterization-and-population-structure-of-indian-rice-cultivars-and-wild-genotypes-using-core-set-markers
#2
Malathi Surapaneni, Divya Balakrishnan, Sukumar Mesapogu, Addanki Krishnam Raju, Yadavalli Venkateswara Rao, Sarla Neelamraju
Genetic diversity among 23 rice genotypes including wild species and cultivars of indica, japonica, aus and aromatic type was investigated using 165 genomewide core set microsatellite (SSR) markers. This genotypic characterization was undertaken to know the genetic similarity among the parental lines to be used in developing a set of chromosome segment substitution lines. In all, 253 alleles were identified using 77 polymorphic SSRs, and polymorphism information content ranged from 0.31 to 0.97 with a mean of 0...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329441/a-framework-for-the-etiology-of-running-related-injuries
#3
REVIEW
M L Bertelsen, A Hulme, J Petersen, R Korsgaard Brund, H Sørensen, C F Finch, E T Parner, R O Nielsen
The etiology of running-related injury is important to consider as the effectiveness of a given running-related injury prevention intervention is dependent on whether etiologic factors are readily modifiable and consistent with a biologically plausible causal mechanism. Therefore, the purpose of the present article was to present an evidence-informed conceptual framework outlining the multifactorial nature of running-related injury etiology. In the framework, four mutually exclusive parts are presented: (A) Structure-specific capacity when entering a running session; (B) Structure-specific cumulative load per running session; (C) Reduction in the structure-specific capacity during a running session; and, (D) Exceeding the structure-specific capacity...
March 22, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28329416/influence-of-continuous-rotation-or-reciprocation-of-optimum-torque-reverse-motion-on-cyclic-fatigue-resistance-of-nickel-titanium-rotary-instruments
#4
E Pedullà, G Corsentino, E Ambu, F Rovai, F Campedelli, S Rapisarda, G R La Rosa, E Rapisarda, S Grandini
AIM: To evaluate the resistance to cyclic fatigue of ProTaper Next (PTN; Dentsply Sirona, Ballaigues, Switzerland), Revo-S (Micro-Mega, Besançon, France), Mtwo (Sweden & Martina, Padova, Italy), Twisted Files (TF, SybronEndo, Orange, CA, USA) and EndoWave (J Morita Corporation, Osaka, Japan) used in continuous rotation or in reciprocation of Optimum Torque Reverse motion (OTR). METHODOLOGY: A total of 120 nickel-titanium files were tested. Twenty-four instruments for each brand were divided into 2 groups (n = 12) on the basis of the motion tested: continuous rotation (Group 1) or reciprocation of OTR motion (Group 2)...
March 22, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28329227/incident-cardiovascular-events-and-death-in-individuals-with-restless-legs-syndrome-or-periodic-limb-movements-in-sleep-a-systematic-review
#5
Tetyana Kendzerska, Maneesha Kamra, Brian J Murray, Mark I Boulos
Study Objectives: To systematically review the current evidence examining restless legs syndrome (RLS) and periodic limb movements (PLMS) as prognostic factors for all-cause mortality and incident cardiovascular events (CVE) in longitudinal studies published in the adult population. Methods: All English language studies (from 1947 to 2016) found through Medline and Embase, as well as bibliographies of identified articles, were considered eligible. Quality was evaluated using published guidelines...
February 9, 2017: Sleep
https://www.readbyqxmd.com/read/28329183/remote-traumatic-brain-injury-is-associated-with-motor-dysfunction-in-older-military-veterans
#6
Raquel C Gardner, Carrie B Peltz, Kimbra Kenney, Kenneth E Covinsky, Ramon Diaz-Arrastia, Kristine Yaffe
Background: Traumatic brain injury (TBI) has been identified as a risk factor for Parkinson's disease (PD). Motor dysfunction among TBI-exposed elders without PD has not been well characterized. We sought to determine whether remote TBI is a risk factor for motor dysfunction on exam and functionally relevant motor dysfunction in day-to-day life among independently living elders without PD. Methods: This is a cross-sectional cohort study of independently living retired military veterans aged 50 or older with (n = 78) and without (n = 85) prior TBI-all without diagnosed PD...
January 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28329181/treatment-response-in-enteric-fever-in-an-era-of-increasing-antimicrobial-resistance-an-individual-patient-data-analysis-of-2-092-participants-enrolled-into-four-randomised-controlled-trials-in-nepal
#7
Corinne N Thompsom, Abhilasha Karkey, Sabina Dongol, Amit Ariyal, Marcel Wolbers, Thomas Darton, Jeremey J Farrar, Guy E Thwaites, Christiane Dolecek, Buddha Basnyat, Stephen Baker
Background: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading cause of bacterial febrile disease in South Asia. Methods: Individual patient data from 2,092 subjects with enteric fever randomised into four trials in Kathmandu, Nepal was pooled. All trials compared gatifloxacin with a comparator drug: cefixime, chloramphenicol, ofloxacin, or ceftriaxone. Treatment outcomes were evaluated according to antimicrobial if S. Typhi/Paratyphi were isolated from blood...
February 28, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28329096/diffuse-white-matter-signal-abnormalities-on-magnetic-resonance-imaging-are-associated-with-human-immunodeficiency-virus-type-1-viral-escape-in-the-central-nervous-system-among-patients-with-neurological-symptoms
#8
Ruthiran Kugathasan, Dami A Collier, Lewis J Haddow, Kate El Bouzidi, Simon G Edwards, Jonathan D Cartledge, Robert F Miller, Ravindra K Gupta
Background.: Human immunodeficiency virus type 1 (HIV-1) can replicate independently in extravascular compartments such as the central nervous system, resulting in either cerebrospinal fluid (CSF) discordance (viral load [VL] in CSF 0.5 log10 copies HIV-1 RNA greater than plasma VL) or escape (detection of HIV VL >50 copies/mL in CSF in patients with suppressed plasma VL <50 copies/mL). Both discordance and escape may be associated with neurological symptoms. We explored risk factors for CSF discordance and escape in patients presenting with diverse neurological problems...
March 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28328979/to-boost-or-to-crunch-effect-of-effortful-encoding-on-episodic-memory-in-older-adults-is-dependent-on-executive-functioning
#9
Li Fu, Joseph H R Maes, Roy P C Kessels, Sander M Daselaar
It is essential to develop effective interventions aimed at ameliorating age-related cognitive decline. Previous studies found that effortful encoding benefits episodic memory in older adults. However, to date it is unclear whether this benefit is different for individuals with strong versus weak executive functioning (EF). Fifty-one older adults were recruited and divided into low (N = 26) and high (N = 25) functioning groups, based on their EF capacity. All participants performed a semantic and a perceptual incidental encoding task...
2017: PloS One
https://www.readbyqxmd.com/read/28328960/norms-and-stigma-regarding-pregnancy-decisions-during-an-unintended-pregnancy-development-and-predictors-of-scales-among-young-women-in-the-u-s-south
#10
Whitney S Rice, Bulent Turan, Kristi L Stringer, Anna Helova, Kari White, Kate Cockrill, Janet M Turan
BACKGROUND: Norms and stigma regarding pregnancy decisions (parenting, adoption, and abortion) are salient to maternal well-being, particularly for groups disproportionately affected by unintended pregnancy. However, there are few validated measures of individual-level perceptions of norms and stigma around pregnancy decisions. Additionally, little is known about variation in the content of norms regarding pregnancy decisions, and in stigma related to violations of these norms, across socio-demographic groups...
2017: PloS One
https://www.readbyqxmd.com/read/28328954/long-term-efficacy-of-oral-calcium-polystyrene-sulfonate-for-hyperkalemia-in-ckd-patients
#11
Mi-Yeon Yu, Jee Hyun Yeo, Joon-Sung Park, Chang Hwa Lee, Gheun-Ho Kim
BACKGROUND: Calcium polystyrene sulfonate (CPS) has long been used to treat hyperkalemia in patients with chronic kidney disease (CKD). However, its efficacy and safety profile have not been systematically explored. We investigated the long-term efficacy of oral CPS for treating mild hyperkalemia on an outpatient basis. METHODS: We performed a retrospective analysis of ambulatory CKD patients who were prescribed CPS for > 1 week because of elevated serum potassium levels > 5...
2017: PloS One
https://www.readbyqxmd.com/read/28328930/validation-of-qpcr-reference-genes-in-lymphocytes-from-patients-with-amyotrophic-lateral-sclerosis
#12
Ewa Usarek, Anna Barańczyk-Kuźma, Beata Kaźmierczak, Beata Gajewska, Magdalena Kuźma-Kozakiewicz
Quantitative polymerase chain reaction (qPCR) is the most specific and reliable method for determination of mRNA gene expression. Crucial point for its accurate normalization is the choice of appropriate internal control genes (ICGs). In the present work we determined and compare the expression of eight commonly used ICGs in lymphocytes from 26 patients with amyotrophic lateral sclerosis (ALS) and 30 control subjects. Peripheral blood mononuclear cells (PBMCs) before and after immortalization by EBV transfection (lymphoblast cell lines-LCLs) were used for qPCR analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28328788/early-presence-of-sleep-spindles-on-electroencephalography-is-associated-with-good-outcome-after-pediatric-cardiac-arrest
#13
Laurence Ducharme-Crevier, Craig A Press, Jonathan E Kurz, Michele G Mills, Joshua L Goldstein, Mark S Wainwright
OBJECTIVES: The role of sleep architecture as a biomarker for prognostication after resuscitation from cardiac arrest in children hospitalized in an ICU remains poorly defined. We sought to investigate the association between features of normal sleep architecture in children after cardiac arrest and a favorable neurologic outcome at 6 months. DESIGN: Retrospective review of medical records and continuous electroencephalography monitoring. SETTING: Cardiac and PICU of a tertiary children's hospital...
March 21, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28328524/paramagnetic-micro-particles-as-a-tool-for-rapid-quantification-of-apixaban-dabigatran-edoxaban-and-rivaroxaban-in-human-plasma-by-uhplc-ms-ms
#14
Martin H J Wiesen, Cornelia Blaich, Thomas Streichert, Guido Michels, Carsten Müller
BACKGROUND: Assessment of the anticoagulant activity of direct oral anticoagulants (DOACs) is justified in special clinical situations. Here, we evaluated two independent extraction methods and developed a multi-analyte ultra-high performance liquid chromatography tandem mass (UHPLC-MS/MS) method for the quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma. METHODS: Routine extraction based on protein precipitation with acetonitrile and subsequent centrifugation was compared to sample clean-up using commercial paramagnetic micro-particles and subsequent magnetic depletion...
March 22, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28328506/a-stimulus-independent-hybrid-bci-based-on-motor-imagery-and-somatosensory-attentional-orientation
#15
Lin Yao, Xinjun Sheng, Dingguo Zhang, Ning Jiang, Natalie Mrachacz-Kersting, Xiangyang Zhu, Dario Farina
Distinctive EEG signals from the motor and somatosensory cortex are generated during mental tasks of motor imagery (MI) and somatosensory attentional orientation (SAO). In this study, we hypothesize that a combination of these two signal modalities provides improvements in BCI performance with respect to using the two methods separately, and generate novel types of multi-class BCI systems. Thirty-two subjects were randomly divided into a Control-Group and a Hybrid-Group. In the Control-Group, the subjects performed left and right hand motor imagery (i...
March 17, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28328281/educational-role-for-an-advanced-suturing-task-in-the-pediatric-laparoscopic-surgery-simulator
#16
Maeve O'Neill Trudeau, Brian Carrillo, Ahmed Nasr, Justin T Gerstle, Georges Azzie
BACKGROUND: Laparoscopic models are recognized as important training tools. Lower fidelity systems are used mainly for simpler tasks; an advanced suturing task may allow for additional training of experts. The purpose of this study was to explore the educational role of an advanced suturing task using motion analysis and establish the task's construct validity. METHODS: The pediatric laparoscopic surgery (PLS) simulator was customized with motion-tracking hardware and software...
March 22, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28328265/student-nurses-perceptions-of-dignity-in-the-care-of-older-people
#17
Leah Macaden, Richard G Kyle, Wayne Medford, Julie Blundell, Sarah-Anne Munoz, Elaine Webster
AIM: The aim of this research was to investigate student nurses' perceptions of the concept of dignity in the care of older people. Student nurses regularly move between the classroom and the clinical setting and are thus ideally placed to cast light on the barriers that exist to providing dignity in care and the way in which their theoretical understanding of dignity is shaped by exposure to the practice setting. METHOD: All student nurses on a three-year undergraduate nursing programme at one university were invited to participate in an online questionnaire survey and focus groups...
March 9, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28328257/differentiating-renal-neoplasms-from-simple-cysts-on-contrast-enhanced-ct-on-the-basis-of-attenuation-and-homogeneity
#18
Nnenaya Agochukwu, Steffen Huber, Michael Spektor, Alexander Goehler, Gary M Israel
OBJECTIVE: The purpose of this study is to compare the attenuation and homogeneity of renal neoplasms with those of cysts on contrast-enhanced CT. MATERIALS AND METHODS: A total of 129 renal neoplasms and 24 simple cysts were evaluated. Two readers determined whether each mass was qualitatively heterogeneous or homogeneous. Mean, minimum, and maximum attenuation values were measured. Statistical analysis was performed. RESULTS: A total of 116 heterogeneous renal cell carcinomas (RCCs) (99 clear cell, four papillary, four oncocytic, seven chromophobe, and two unclassified RCCs), 13 homogeneous RCCs (10 papillary, two oncocytic, and one chromophobe RCC), and 24 cysts (all of which were homogeneous) were evaluated...
April 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28328165/variation-in-growth-rate-carbon-assimilation-and-photosynthetic-efficiency-in-response-to-nitrogen-source-and-concentration-in-phytoplankton-isolated-from-upper-san-francisco-bay
#19
Gry Mine Berg, Sara Driscoll, Kendra Hayashi, Melissa Ross, Raphael Kudela
Six species of phytoplankton recently isolated from upper San Francisco Bay were tested for their sensitivity to growth inhibition by ammonium (NH4(+) ), and for differences in growth rates according to inorganic nitrogen (N) growth source. The quantum yield of photosystem II (Fv /Fm ) was a sensitive indicator of NH4(+) toxicity, manifested by a suppression of Fv /Fm in a dose-dependent manner. Two chlorophytes were the least sensitive to NH4(+) inhibition, at concentrations of >3000 μmoles NH4(+) · L(-1) , followed by two estuarine diatoms which were sensitive at concentrations >1000 μmoles NH4(+) · L(-1) , followed lastly by two freshwater diatoms that were sensitive at concentrations between 200-500 μmoles NH4(+) · L(-1) ...
March 22, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28328159/improved-disease-activity-with-fosdagrocorat-pf-04171327-a-partial-agonist-of-the-glucocorticoid-receptor-in-patients-with-rheumatoid-arthritis-a-phase-2-randomized-study
#20
Thomas Stock, Dona Fleishaker, Xin Wang, Arnab Mukherjee, Charles Mebus
AIM: To assess efficacy and safety of fosdagrocorat (PF-04171327), a potential dissociated agonist of the glucocorticoid receptor, in rheumatoid arthritis (RA) patients. METHODS: This multicenter, double-blind, parallel-group, active- and placebo-controlled Phase 2 study (NCT00938587) randomized 86 patients (1 : 1 : 1 : 1) to receive fosdagrocorat 10 mg, fosdagrocorat 25 mg, prednisone 5 mg or placebo, all with stable background methotrexate therapy. The primary outcome was change from baseline in Disease Activity Score of 28 joints (DAS28-4[C-reactive protein (CRP)]) after 2 weeks of treatment...
March 22, 2017: International Journal of Rheumatic Diseases
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