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JOURNAL ARTICLE
Melle Säve-Söderbergh, Irina Gyllenhammar, Tessa Schillemans, Emelie Lindfeldt, Carolina Vogs, Carolina Donat-Vargas, Emma Halldin Ankarberg, Anders Glynn, Lutz Ahrens, Emilie Helte, Agneta Åkesson
BACKGROUND: There is inconclusive evidence for an association between per- and polyfluoroalkyl substances (PFAS) and fetal growth. OBJECTIVES: We conducted a nation-wide register-based cohort study to assess the associations of the estimated maternal exposure to the sum (PFAS4) of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorohexane sulfonic acid (PFHxS) with birthweight as well as risk of small- (SGA) and large-for-gestational-age (LGA)...
May 8, 2024: Environment International
#2
JOURNAL ARTICLE
Zulfaqar Sa'adi, Mohammad Saleh Al-Suwaiyan, Zaher Mundher Yaseen, Mou Leong Tan, Leonardo Goliatt, Salim Heddam, Bijay Halder, Iman Ahmadianfar, Raad Z Homod, Shafik S Shafik
Climate change has significantly altered the characteristics of climate zones, posing considerable challenges to ecosystems and biodiversity, particularly in Borneo, known for its high species density per unit area. This study aimed to classify the region into homogeneous climate groups based on long-term average behavior. The most effective parameters from the high-resolution daily gridded Princeton climate datasets spanning 65 years (1950-2014) were utilized, including rainfall, relative humidity (RH), temperatures (Tavg, Tmin, Tmax, and diurnal temperature range (DTR)), along with elevation data at 0...
May 11, 2024: Journal of Environmental Management
#3
JOURNAL ARTICLE
Yeşim Aslan Kanmaz, Saime Betül Baygeldi, Barış Can Güzel, Yücehan Yılmaz, Meryem Karan, Betül Dağoğlu Hark, Sadık Yılmaz
This study aimed to determine the morphometric measurements anatomically and CT images of skulls of healthy male and female rabbits during postnatal development, to analyse the data statistically and to demonstrate the structural changes in bone. A total of 40 rabbits (20 females and 20 males) were divided into four groups including prepubertal period (group I (0-1 month)), period between adolescence and adulthood (group II (3-5 month)) and later (young adult period as group III (1-3 years) and old adult period as group IV (3-5 years)), with five animals in each group...
May 2024: Anatomia, Histologia, Embryologia
#4
JOURNAL ARTICLE
Jishnu Malgie, Mariëlle I Wilde, Pascal R D Clephas, Mireille E Emans, Stefan Koudstaal, Jeroen Schaap, Arend Mosterd, Jan van Ramshorst, Alexander J Wardeh, Sandra van Wijk, Mieke van den Heuvel, Eric Wierda, C Jan Willem Borleffs, Colette Saraber, Saskia L M A Beeres, Roland van Kimmenade, Wouter Jansen Klomp, Robert Denham, Carlos A da Fonseca, IJsbrand T Klip, Olivier C Manintveld, Robert M A van der Boon, Clara E E van Ofwegen, Ayten Yilmaz, Ron Pisters, Gerard C M Linssen, Nikola Faber, Loek van Heerebeek, Julio E C van de Swaluw, Lex J Bouhuijzen, Marco C Post, Aaf F M Kuijper, Ka Wai Wu, Eugène A van Beek, Tim Hesselink, Lennaert Kleijn, Maurice J M Kurvers, René A Tio, Jorina Langerveld, Bas M van Dalen, J W Martijn van Eck, M Louis Handoko, Walter R M Hermans, Hetty J J Koornstra-Wortel, Mariusz K Szymanski, Dennis Rooker, Kenneth Tandjung, Sabine C M Eijsbouts, Folkert W Asselbergs, Peter van der Meer, Hans-Peter Brunner-La Rocca, Rudolf A de Boer, Jasper J Brugts
AIMS: Despite clear guideline recommendations for initiating four drug classes in all patients with heart failure (HF) with reduced ejection fraction (HFrEF) and the availability of rapid titration schemes, information on real-world implementation lags behind. Closely following the 2021 ESC HF guidelines and 2023 focused update, the TITRATE-HF study started to prospectively investigate the use, sequencing, and titration of guideline-directed medical therapy (GDMT) in HF patients, including the identification of implementation barriers...
May 12, 2024: European Journal of Heart Failure
#5
JOURNAL ARTICLE
Lydia M Theodoropoulou, Niamh A Cullen
BACKGROUND: Diet restrictions and fear of adverse reactions put a significant burden on the nutrition, growth and life style of children and adults with food allergies. While various disease-modifying options are pursued, there are so far no published clinical data on immunotherapy for crustaceans. The efficacy and safety of desensitization to crustaceans by means of sublingual immunotherapy is assessed for the first time in this study with a view of validating it as a clinical-practice modality...
May 11, 2024: Allergy, Asthma, and Clinical Immunology
#6
REVIEW
Wenxia Li, Jun Meng, Jing Lei, Cheng Li, Wei Yue
BACKGROUND: Carbon monoxide (CO) poisoning is now one of the leading causes of poisoning-related mortality worldwide. The central nervous system is the most vulnerable structure in acute CO poisoning. MRI is of great significance in the diagnosis and prognosis of CO toxic encephalopathy. The imaging features of CO poisoning are diverse. We report atypical hippocampal lesions observed on MRI in four patients after acute CO exposure. CASE PRESENTATIONS: We report four patients who presented to the emergency department with loss of consciousness...
May 11, 2024: BMC Neurology
#7
JOURNAL ARTICLE
Jie Lai, Bianca Pilla, Matthew Stephenson, Alison Brettle, Chunlan Zhou, Wenji Li, Chaixiu Li, Jiaqi Fu, Shisi Deng, Yujie Zhang, Zihan Guo, Yanni Wu
BACKGROUND: Chemotherapy, whilst treating tumours, can also lead to numerous adverse reactions such as nausea and vomiting, fatigue and kidney toxicity, threatening the physical and mental health of patients. Simultaneously, misuse of chemotherapeutic drugs can seriously endanger patients' lives. Therefore, to maintain the safety of chemotherapy for cancer patients and to reduce the incidence of adverse reactions to chemotherapy, many guidelines state that a comprehensive assessment of the cancer patient should be conducted and documented before chemotherapy...
May 11, 2024: BMC Nursing
#8
JOURNAL ARTICLE
K Escobedo-Quevedo, M J Lankheet, I Pen, M Trienens, H H M Helsen, B Wertheim
BACKGROUND: Foraging behavior in insects is optimised for locating scattered resources in a complex environment. This behavior can be exploited for use in pest control. Inhibition of feeding can protect crops whereas stimulation can increase the uptake of insecticides. For example, the success of a bait spray, depends on either contact or ingestion, and thus on the insect finding it. METHODS: To develop an effective bait spray against the invasive pest, Drosophila suzukii, we investigated aspects of foraging behavior that influence the likelihood that the pest interacts with the baits, in summer and winter morphotypes...
May 11, 2024: BMC ecology and evolution
#9
JOURNAL ARTICLE
B E Meyerson, J Agley, R A Crosby, K G Bentele, N Vadiei, L B Linde-Krieger, D R Russell, K Fine, L A Eldridge
BACKGROUND: Pharmacy syringe sales are effective structural interventions to reduce bloodborne illnesses in populations, and are legal in all but two states. Yet evidence indicates reduced syringe sales in recent years. This study was designed as a feasibility test of an intervention to promote syringe sales by pharmacies in Arizona. METHODS: A four-month pilot among three Arizona pharmacies measured feasibility and acceptability through monthly surveys to 18 enrolled pharmacy staff members...
May 7, 2024: Research in Social & Administrative Pharmacy: RSAP
#10
JOURNAL ARTICLE
Ayon Chakraborty, Rajesh Ghosh, Saswati Soumya Mohapatra, Subhashree Barik, Ashis Biswas, Snehasis Chowdhuri
The global mortality rate has been significantly impacted by the COVID-19 pandemic, caused by the SARS CoV-2 virus. Although the pursuit for a potent antiviral is still in progress, experimental therapies based on repurposing of existing drugs is being attempted. One important therapeutic target for COVID-19 is the main protease (Mpro) that cleaves the viral polyprotein in its replication process. Recently minocycline, an antimycobacterium drug, has been successfully implemented for the treatment of COVID-19 patients...
May 9, 2024: Gene
#11
JOURNAL ARTICLE
Baochen Li, Chunli Zhu, Da Ouyang, Ting Guo, Xiaodong Wu, Yimin Cai, Haibo Zhang
Due to the similar sources of swage irrigation, organic fertilizer, and sludge application, microplastics (MPs) and antibiotics coexist inevitably in the agriculture soils. However, the impacts of MPs with different polymer types and aging status on the bio-accessibility of co-existing antibiotics in soils remained unclear. Therefore, we using the diffusive gradients films for organic compounds devices (o-DGT) to evaluated the distribution of sulfadiazine (SDZ) in both paddy soil and saline soil amended with 0...
May 9, 2024: Science of the Total Environment
#12
JOURNAL ARTICLE
Xiaozhen Chen, Feidi Wang, Haikun Guo, Xinju Liu, Shenggan Wu, Lu Lv, Tao Tang
Studying the toxic effects of pesticides on bees has consistently been a prominent area of interest for researchers. Nonetheless, existing research has predominantly concentrated on individual toxicity assessments, leaving a gap in our understanding of mixed toxicity. This study delves into the individual and combined toxic effects of abamectin (ABA) and lambda-cyhalothrin (LCY) on honey bees (Apis mellifera) in laboratory settings. We discovered that ABA (96 h-LC50 value of 0.079 mg/L) exhibited greater acute toxicity to honey bees compared to LCY (96 h-LC50 value of 9...
May 9, 2024: Science of the Total Environment
#13
JOURNAL ARTICLE
Anthony M Mills, Giuliano Rizzardini, Moti N Ramgopal, Olayemi O Osiyemi, Johannes R Bogner, Debbie P Hagins, Roger Paredes, Jacques Reynes, Jürgen K Rockstroh, Andrew Carr, Feng-Hsiu Su, Stephanie O Klopfer, Karen Eves, Rebeca M Plank, Todd Correll, Michelle C Fox
BACKGROUND: Doravirine and islatravir is an investigational, once-daily regimen with high antiviral potency, favourable safety and tolerability, and a low propensity for resistance. We investigated a switch from bictegravir, emtricitabine, and tenofovir alafenamide to doravirine (100 mg) and islatravir (0·75 mg) in virologically suppressed adults with HIV-1. METHODS: We conducted a phase 3, multicentre, randomised, active-controlled, double-blind, double-dummy, non-inferiority trial at 89 research, community, and hospital-based clinics in 11 countries...
May 8, 2024: Lancet HIV
#14
JOURNAL ARTICLE
Jean-Michel Molina, Giuliano Rizzardini, Catherine Orrell, Alejandro Afani, Alexandra Calmy, Shinichi Oka, Federico Hinestrosa, Princy Kumar, Pablo Tebas, Sharon Walmsley, Anjana Grandhi, Stephanie Klopfer, Isaias Gendrano, Karen Eves, Todd A Correll, Michelle C Fox, Jason Kim
BACKGROUND: Doravirine and islatravir is an investigational, once-daily, single-tablet regimen with high antiviral potency, favourable safety and tolerability, and low propensity for resistance. We report week 48 results from a phase 3 trial evaluating switch from stable, oral antiretroviral therapy (ART) to the fixed combination of doravirine (100 mg) and islatravir (0·75 mg). METHODS: This phase 3, multicentre, randomised, active-controlled, open-label, non-inferiority trial was conducted at 77 research, community, and hospital-based clinics in 15 countries...
May 8, 2024: Lancet HIV
#15
JOURNAL ARTICLE
Borgohain Anima, Guruswami Gurusubramanian, Vikas Kumar Roy
AIMS: Polycystic ovarian syndrome (PCOS) is one of the most common (about 5-20%) reproductive disorders in women of reproductive age; it is characterized by polycystic ovaries, hyperandrogenism, and oligo/ anovulation. The levels and expression of ovarian adipokines are deregulated in the PCOS. Apelin is an adipokine that acts through its receptor (APJ) and is known to express in the various tissues including the ovary. It has also been suggested that apelin and APJ could be targeted as therapeutic adjuncts for the management of PCOS...
May 10, 2024: Cytokine
#16
JOURNAL ARTICLE
Jürgen Krücken, Paula Ehnert, Stefan Fiedler, Fabian Horn, Christina S Helm, Sabrina Ramünke, Tanja Bartmann, Alexandra Kahl, Ann Neubert, Wiebke Weiher, Ricarda Daher, Werner Terhalle, Alexandra Klabunde-Negatsch, Stephan Steuber, Georg von Samson-Himmelstjerna
Anthelmintic resistance in sheep parasitic gastrointestinal nematodes is widespread and a severe health and economic issue but prevalence of resistance and involved parasite species are unknown in Germany. Here, the faecal egg count reduction test (FECRT) was performed on eight farms using fenbendazole, ivermectin and moxidectin and on four farms using only moxidectin. A questionnaire was used to obtain data on management practices to potentially identify risk factors for presence of resistance. All requirements of the recently revised WAAVP guideline for diagnosing anthelmintic resistance using the FECRT were applied...
May 5, 2024: International Journal for Parasitology, Drugs and Drug Resistance
#17
JOURNAL ARTICLE
Jignesh Tandel, Vivek Shetty, Yash Wagh, Sajeev Shekhar, Aniket Wagh, J M Parvathy, Vikas Karade, Amit Maurya
PURPOSE: The standard principle of total knee arthroplasty (TKA) targeted by most orthopaedicians is the alignment of the lower limb in a neutral mechanical axis. However, for several patients the neutral mechanical alignment is not normal. Aligning these patients to a neutral mechanical axis may not result in desirable outcomes as it may feel unnatural. This study aimed to discover what percentage of the young healthy Indian population have a neutral hip-knee-ankle angle (HKA = 180°) and what percentage of this population have a deviation from the neutral HKA...
May 10, 2024: Knee
#18
JOURNAL ARTICLE
Shijie Zhao, Shenshen Gu
As a special type of multi-objective combinatorial optimization problems (MOCOPs), the multi-objective traveling salesman problem (MOTSP) plays an important role in practical fields such as transportation and robot control. However, due to the complexity of its solution space and the conflicts between different objectives, it is difficult to obtain satisfactory solutions in a short time. This paper proposes an end-to-end algorithm framework for solving MOTSP based on deep reinforcement learning (DRL). By decomposing strategies, solving MOTSP is transformed into solving multiple single-objective optimization subproblems...
May 3, 2024: Neural Networks: the Official Journal of the International Neural Network Society
#19
JOURNAL ARTICLE
Griet Verboven, Imke Lodewijkx, Laura Van den Bosch, Manon Huizing, Mireille Van Goethem, Glenn Broeckx, Wiebren A Tjalma
Historically, it has been believed that invasive lobular carcinomas (ILC) occur more frequently bilaterally compared to other invasive subtypes, with estimates ranging between 20% and 29%. This study aims to determine if this historical perspective still holds true. A comprehensive literature review was conducted to examine the bilateral occurrence of lobular carcinoma using various imaging methods. Additionally, the role of magnetic resonance imaging (MRI) in detecting contralateral carcinomas was also investigated...
May 1, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
#20
JOURNAL ARTICLE
Fangfang Duan, Xin Hua, Xiwen Bi, Shusen Wang, Yanxia Shi, Fei Xu, Li Wang, Jiajia Huang, Zhongyu Yuan, Yuanyuan Huang
BACKGROUND: To explore whether specific clinicopathological covariates are predictive for a benefit from capecitabine maintenance in early-stage triple-negative breast cancer (TNBC) in the SYSUCC-001 phase III clinical trial. METHODS: Candidate covariates included age, menstrual status, type of surgery, postoperative chemotherapy regimen, Ki-67 percentage, histologic grade, primary tumor size, lymphovascular invasion, node status, and capecitabine medication...
May 6, 2024: Breast: Official Journal of the European Society of Mastology
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