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https://www.readbyqxmd.com/read/28449478/protective-effect-of-propofol-preconditioning-on-ischemia-reperfusion-injury-in-human-hepatocyte
#1
Yuzhu Zhang, Zhenzhen Chen, Nianhai Feng, Junxia Tang, Xingbo Zhao, Chengxiao Liu, Hongyu Xu, Mengyuan Zhang
BACKGROUND: Blood reperfusion after ischemia is the main measure to restore cell function. This study was aimed to explore the effect of propofol on rat and cell models of liver ischemia-reperfusion (I/R) injury, and to investigate its possible mechanism. METHODS: Wistar rats were divided into four groups: control group, sham group, I/R group, and propofol group. Human hepatocyte HL7702 was divided into six groups: control group, I/R group and propofol (5, 10, 20 and 40 µmol/L) groups...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449386/influence-of-a-two-to-six-year-physical-education-intervention-on-scholastic-performance-the-champs-study-dk
#2
Anna Bugge, Sören Möller, Jakob Tarp, Charles H Hillman, Rodrigo Antunes Lima, Anne Kaer Gejl, Heidi Klakk, Niels Wedderkopp
AIM: To investigate the influence of a school-based intervention with a tripling of physical education (PE) lessons from two (90 min) to six lessons per week (270 min) on scholastic performance. METHODS: This study is part of the CHAMPS study-DK, a quasi-experimental study that began in 2008. The intervention group consisted of six schools and the control group consisted of four matched schools (mean age at baseline = 8.4 years, kindergarten class-4(th) grade). Academic performance was extracted from the national test system from 2010- 2014 (Math and Danish were measured at 3(rd) and 6(th) , and 2(nd) , 4(th) and 6(th) grades, respectively)...
April 27, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28449374/genetic-variability-in-adenosine-deaminase-like-contributes-to-variation-in-alcohol-preference-in-mice
#3
Heidi M B Lesscher, Alexis Bailey, Louk J M J Vanderschuren
BACKGROUND: A substantial part of the risk for alcohol use disorder (AUD) is determined by genetic factors. We previously used chromosome substitution (CSS) mice, to identify a QTL for alcohol preference on mouse chromosome 2. The aim of this study was to identify candidate genes within this QTL that confer the risk for alcohol preference. METHODS: In order to delineate the neurobiological underpinnings of alcohol consumption, we expanded on the QTL approach to identify candidate genes for high alcohol preference in mice...
April 27, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28449332/behavioural-disinhibition-in-the-general-population-during-the-antiretroviral-therapy-roll-out-in-sub-saharan-africa-systematic-review-and-meta-analysis
#4
REVIEW
Eva M Legemate, Jan A C Hontelez, Caspar W N Looman, Sake J De Vlas
OBJECTIVES: Improved life expectancy and reduced transmission probabilities due to ART may result in behavioural disinhibition - i.e. an increase in sexual risk behaviour in response to a perceived lower risk of HIV. We examined trends in sexual risk behaviour in the general population of sub-Saharan African countries 1999 - 2015. METHODS: We systematically reviewed scientific literature of sexual behaviour, and reviewed trends in Demographic and Health Surveys...
April 27, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28449313/neurovascular-unit-alteration-in-somatosensory-cortex-and-enhancement-of-thermal-nociception-induced-by-amphetamine-involves-central-at1-receptor-activation
#5
Victoria Belén Occhieppo, Natalia Andrea Marchese, Iara Diamela Rodríguez, Osvaldo Martín Basmadjian, Gustavo Baiardi, Claudia Bregonzio
The use of psychostimulants, such as amphetamine (Amph), is associated with inflammatory processes, involving glia and vasculature alterations. Brain Angiotensin II (Ang II), through AT1 -receptors (AT1 -R), modulates neurotransmission and plays a crucial role in inflammatory responses in brain vasculature and glia. Our aim for the present work was to evaluate the role of AT1 -R in long-term alterations induced by repeated exposure to Amph. Astrocyte reactivity, neuronal survival and brain microvascular network were analyzed at the somatosensory cortex...
April 27, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28449312/the-effect-of-sclerotherapy-and-prolotherapy-on-chronic-painful-achilles-tendinopathy-a-systematic-review-including-meta-analysis
#6
REVIEW
Oliver Morath, Eva Johanna Kubosch, Jan Taeymans, Jörn Zwingmann, Lukas Konstantinidis, Norbert P Südkamp, Anja Hirschmüller
Chronic painful AT is a common disorder among athletes. Sclerotherapy (ST) and prolotherapy (AT) are two promising options among the numerous other conservative therapies. Since their efficacy and potential adverse effects (AE) are still unclear, we systematically searched, analysed, and synthesised the available literature on ST and PT for treatingAT. Electronic databases, GoogleScholar and articles' reference lists were searched according to PRISMA guidelines. Eligibility criteria were set up according to the PICOS-scheme including human and animal studies...
April 27, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28449298/all-silicon-switchable-magnetoelectric-effect-via-interlayer-exchange-coupling
#7
Hang Liu, Jia Tao Sun, Huixia Fu, Peijie Sun, Yuanping Feng, Sheng Meng
The magnetoelectric (ME) effect originating from the effective coupling between electric field and magnetism is an exciting frontier in nanoscale science such as magnetic tunneling junction (MTJ), ferroelectric/piezoelectric heterojunctions etc. The realization of switchable ME effect under external electric field in d^0 semiconducting materials of single composition is needed especially for all-silicon spintronics applications because of its natural compatibility with current industry. We employ the density functional theory (DFT) to reveal that the pristine Si(111)-√3×√3R30º (Si√3 hereafter) reconstructed surfaces of thin films with thickness smaller than eleven bilayers support sizeable linear ME effect with switchable direction of magnetic moment under external electric field...
April 27, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28449229/exposure-to-texture-of-foods-for-8-month-old-infants-does-the-size-of-the-pieces-matter
#8
Saakje P da Costa, Lianne Remijn, Hugo Weenen, Carel Vereijken, Cees van der Schans
The present study examined the effect of meals varying in amount, size, and hardness of food pieces on the development of the chewing capabilities of 8-month-old infants. The study also examined changes in shivering, gagging, coughing, choking, and their ability to eat from a spoon. In an in-home setting two groups were given commercially available infant meals and fruits, purees with either less, smaller and softer or more, larger and harder pieces. Both groups were given these foods for 4 weeks and were monitored several times during this period...
April 27, 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28449209/the-frequency-of-qtc-prolongation-among-pediatric-and-young-adult-patients-receiving-methadone-for-cancer-pain
#9
Kevin Madden, Minjeong Park, Diane Liu, Eduardo Bruera
INTRODUCTION: A prolonged corrected QT (QTc) interval in pediatric patients is defined as ≥470 msec. Methadone can cause a prolonged QTc interval that can lead to ventricular arrhythmias. The risk of methadone-induced prolongation of the QTc interval in children and young adults is unknown. The purpose of the study was to determine the frequency of QTc prolongation among pediatric and young adult patients with cancer pain on methadone treatment. METHODS: We retrospectively reviewed data for all patients on methadone during the study period...
April 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28448979/combination-of-correctors-rescues-cftr-transmembrane-domain-mutants-by-mitigating-their-interactions-with-proteostasis
#10
Miquéias Lopes-Pacheco, Clément Boinot, Inna Sabirzhanova, Daniele Rapino, Liudmila Cebotaru
BACKGROUND/AIMS: Premature degradation of mutated cystic fibrosis transmembrane conductance regulator (CFTR) protein causes cystic fibrosis (CF), the commonest Mendelian disease in Caucasians. Despite recent advances in precision medicines for CF patients, many CFTR mutants have not been characterized and the effects of these new therapeutic approaches are still unclear for those mutants. METHODS: Cells transfected or stably expressing four CFTR transmembrane-domain mutants (G85E, E92K, L1077P, and M1101K) were used to: 1) characterize the mutants according to their protein expression, thermal sensitivity, and degradation pathways; 2) evaluate the effects of correctors in rescuing them; and 3) explore the effects of correctors on CFTR interactions with proteostasis components...
April 25, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28448904/support-for-marijuana-legalization-in-the-us-state-of-washington-has-continued-to-increase-through-2016
#11
Meenakshi Sabina Subbaraman, William C Kerr
BACKGROUND: Support for the legalization of recreational marijuana continues to increase across the United States and globally. In 2016, recreational marijuana was legalized in the most populous US state of California, as well as three other states. The primary aim of this study was to examine trends in support for recreational marijuana legalization in Washington, a state which has had legal recreational marijuana for almost four years, using data collected over the four years post-legalization...
April 19, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28448771/geosmithia-associated-with-bark-beetles-and-woodborers-in-the-western-usa-taxonomic-diversity-and-vector-specificity
#12
Miroslav Kolařík, Jiri Hulcr, Ned Tisserat, Wilhelm De Beer, Martin Kostovčík, Zuzana Kolaříková, Steven J Seybold, David M Rizzo
Fungi in the genus Geosmithia (Ascomycota: Hypocreales) are frequent associates of bark beetles and woodborers that colonize hardwood and coniferous trees. One species, Geosmithia morbida, is an economically damaging invasive species. The authors surveyed the Geosmithia species of California and Colorado, USA, to (i) provide baseline data on taxonomy of Geosmithia and beetle vector specificity across the western USA; (ii) investigate the subcortical beetle fauna for alternative vectors of the invasive G. morbida; and (iii) interpret the community composition of this region within the emerging global biogeography of Geosmithia...
April 24, 2017: Mycologia
https://www.readbyqxmd.com/read/28448763/analysis-of-postoperative-ultrasonography-surveillance-after-hemithyroidectomy-in-patients-with-papillary-thyroid-microcarcinoma-a-multicenter-study
#13
Hye Jin Baek, Dong Wook Kim, Chang Yoon Lee, Jung Yin Huh, Jin Yong Sung, Yoon Jung Choi
OBJECTIVE: The optimal follow-up interval for postoperative ultrasonography (US) surveillance after hemithyroidectomy in patients with papillary thyroid microcarcinoma (PTMC) is unclear. The purpose of this study was to evaluate the prevalence of tumor recurrence/persistence and to investigate the appropriateness of postoperative US surveillance in PTMC patients who underwent hemithyroidectomy. METHODS: Our institutional review board approved this retrospective study...
April 27, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28448690/evaluation-of-column-length-and-particle-size-effect-on-the-untargeted-profiling-of-a-phytochemical-mixture-by-using-uhplc-coupled-to-high-resolution-mass-spectrometry
#14
Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Chiara Cavaliere, Francesca Ferraris, Giorgia La Barbera, Susy Piovesana, Aldo Laganà
Liquid chromatography coupled to high-resolution mass spectrometry is the technique of choice for the untargeted profiling of food matrices. Despite the high potential of high-resolution mass spectrometry, when dealing with complex mixtures, an efficient separation technique is also needed. The novel core-shell chromatographic columns packed with sub-2 μm sized particles are claimed to show very good resolution. However, the analytes retention can be significantly altered when working under ultra-high performance chromatographic conditions...
April 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28448682/validation-of-the-behavioural-observation-scale-3-for-the-evaluation-of-pain-in-adults
#15
M Frasca, B Burucoa, S Domecq, N Robinson, V Dousset, M Cadenne, F Sztark, M Floccia
BACKGROUND: Many behavioural scales are available to assess pain but none are suitable for a quick evaluation of non-sedated and non-geriatric adults. The Behavioural Observation Scale 3 (BOS-3) is short, composed of five items. This study examined its feasibility and diagnostic performances. METHODS: Adult patients were included from medical and surgical departments of the University Hospital of Bordeaux. In a cross-sectional study, BOS-3 was compared to Numerical Rate Scale (NRS) with communicating patients (CP) and Behavioural Scale for the Elderly Person (ECPA2) with non-communicating patients (NCP)...
April 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28448621/biochar-from-kon-tiki-flame-curtain-and-other-kilns-effects-of-nutrient-enrichment-and-kiln-type-on-crop-yield-and-soil-chemistry
#16
Naba Raj Pandit, Jan Mulder, Sarah Elisabeth Hale, Hans Peter Schmidt, Gerard Cornelissen
Biochar application to soils has been investigated as a means of improving soil fertility and mitigating climate change through soil carbon sequestration. In the present work, the invasive shrub "Eupatorium adenophorum" was utilized as a sustainable feedstock for making biochar under different pyrolysis conditions in Nepal. Biochar was produced using several different types of kilns; four sub types of flame curtain kilns (deep-cone metal kiln, steel shielded soil pit, conical soil pit and steel small cone), brick-made traditional kiln, traditional earth-mound kiln and top lift up draft (TLUD)...
2017: PloS One
https://www.readbyqxmd.com/read/28448592/blood-type-abo-genetic-variants-and-ovarian-cancer-survival
#17
Gabriella D Cozzi, Rebecca T Levinson, Hilary Toole, Malcolm-Robert Snyder, Angie Deng, Marta A Crispens, Dineo Khabele, Alicia Beeghly-Fadiel
OBJECTIVE: Blood type A and the A1 allele have been associated with increased ovarian cancer risk. With only two small studies published to date, evidence for an association between ABO blood type and ovarian cancer survival is limited. METHODS: We conducted a retrospective cohort study of Tumor Registry confirmed ovarian cancer cases from the Vanderbilt University Medical Center with blood type from linked laboratory reports and ABO variants from linked Illumina Exome BeadChip data...
2017: PloS One
https://www.readbyqxmd.com/read/28448581/the-performance-of-bd-facspresto%C3%A2-for-cd4-t-cell-count-cd4-and-hemoglobin-concentration-test-in-ethiopia
#18
Gebremedhin Gebremicael, Yohanes Belay, Fitsum Girma, Yemane Abreha, Atsbeha Gebreegziabxier, Simret Tesfaye, Zelalem Messele, Yibeltal Assefa, Bahrie Bellete, Desta Kassa, Lara Vojnov
INTRODUCTION: In Ethiopia, CD4+ T-cell counting is still required for all patients at baseline before antiretroviral therapy (ART) and to determine eligibility and follow-up of opportunistic infection prophylaxis. However, access to CD4+ T cell count in rural health facilities remains a major challenge in Ethiopia like other resource-limited settings. METHODOLOGY: Both capillary and venous blood was drawn from each of 325 study participant recruited in Addis Ababa and surroundings...
2017: PloS One
https://www.readbyqxmd.com/read/28448536/lateral-flow-immunoassay-for-on-site-detection-of-xanthomonas-arboricola-pv-pruni-in-symptomatic-field-samples
#19
Pablo López-Soriano, Patricia Noguera, María Teresa Gorris, Rosa Puchades, Ángel Maquieira, Ester Marco-Noales, María M López
Xanthomonas arboricola pv. pruni is a quarantine pathogen and the causal agent of the bacterial spot disease of stone fruits and almond, a major threat to Prunus species. Rapid and specific detection methods are essential to improve disease management, and therefore a prototype of a lateral flow immunoassay (LFIA) was designed for the detection of X. arboricola pv. pruni in symptomatic field samples. It was developed by producing polyclonal antibodies which were then combined with carbon nanoparticles and assembled on nitrocellulose strips...
2017: PloS One
https://www.readbyqxmd.com/read/28448373/effects-of-parental-stress-optimism-and-health-promoting-behaviors-on-the-quality-of-life-of-primiparous-and-multiparous-mothers
#20
Jennifer Loh, Craig Harms, Bronwyn Harman
BACKGROUND: Parental stress, optimism, and health-promoting behaviors (HPBs) are important predictors of the quality of life (QoL) of mothers. However, it is unclear how strongly these predictors affect the QoL of mothers. It is also unclear if the impact of these predictors on QoL differs between primiparous and multiparous mothers. In this study, we defined primiparous as "bearing young for the first time" and multiparous as "having experienced one or more previous childbirths." OBJECTIVES: The first objective of this study was to examine the relative effect of parental stress, optimism, and HPBs on the QoL of mothers...
May 2017: Nursing Research
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