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https://www.readbyqxmd.com/read/28881031/ribavirin-steady-state-plasma-level-is-a-predictor-of-sustained-virological-response-in-hepatitis-c-infected-patients-treated-with-direct-acting-antivirals
#1
M van Tilborg, F I Lieveld, E J Smolders, K J van Erpecum, C T M M de Kanter, R Maan, M van der Valk, J E Arends, A S M Dofferhoff, H Blokzijl, M Bijmolen, J P H Drenth, R J de Knegt, D M Burger
BACKGROUND: In the era of highly effective direct-acting antivirals (DAAs) for treatment of patients with chronic hepatitis C virus (HCV) infection, ribavirin (RBV) is still considered beneficial in certain patients. AIM: To assess the association between RBV steady-state plasma levels and sustained virological response (SVR). METHODS: Consecutive HCV-infected patients treated with DAAs plus RBV from four Dutch academic medical centres were enrolled...
September 7, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28874164/radiation-free-cmr-diagnostic-heart-catheterization-in-children
#2
Kanishka Ratnayaka, Joshua P Kanter, Anthony Z Faranesh, Elena K Grant, Laura J Olivieri, Russell R Cross, Ileen F Cronin, Karin S Hamann, Adrienne E Campbell-Washburn, Kendall J O'Brien, Toby Rogers, Michael S Hansen, Robert J Lederman
BACKGROUND: Children with heart disease may require repeated X-Ray cardiac catheterization procedures, are more radiosensitive, and more likely to survive to experience oncologic risks of medical radiation. Cardiovascular magnetic resonance (CMR) is radiation-free and offers information about structure, function, and perfusion but not hemodynamics. We intend to perform complete radiation-free diagnostic right heart catheterization entirely using CMR fluoroscopy guidance in an unselected cohort of pediatric patients; we report the feasibility and safety...
September 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28739290/implementation-of-the-canadian-ct-head-rule-and-its-association-with-use-of-computed-tomography-among-patients-with-head-injury
#3
Adam L Sharp, Brian Z Huang, Tania Tang, Ernest Shen, Edward R Melnick, Arjun K Venkatesh, Michael H Kanter, Michael K Gould
STUDY OBJECTIVE: Approximately 1 in 3 computed tomography (CT) scans performed for head injury may be avoidable. We evaluate the association of implementation of the Canadian CT Head Rule on head CT imaging in community emergency departments (EDs). METHODS: We conducted an interrupted time-series analysis of encounters from January 2014 to December 2015 in 13 Southern California EDs. Adult health plan members with a trauma diagnosis and Glasgow Coma Scale score at ED triage were included...
July 21, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28667743/hidradenitis-suppurativa-and-electrocardiographic-changes-a-cross-sectional-population-study
#4
C R Juhl, I M Miller, G B Jemec, J K Kanters, C Ellervik
BACKGROUND: Hidradenitis Suppurativa (HS) is a chronic, inflammatory skin disease, recently associated with metabolic syndrome, subclinical atherosclerosis and increased risk of cardiovascular disease. OBJECTIVES: The aim of the study was to investigate the hitherto unknown electrocardiographic changes associated with HS, which recently have been associated with significant cardiovascular burden. METHODS: Data were derived from the cross-sectional population study, The Danish General Population Study (GESUS)...
July 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28589536/distinguishing-pathogenic-mutations-from-background-genetic-noise-in-cardiology-the-use-of-large-genome-databases-for-genetic-interpretation
#5
REVIEW
Jonas Ghouse, Morten W Skov, Robert S Bigseth, Gustav Ahlberg, Jørgen K Kanters, Morten S Olesen
Advances in clinical genetic testing has led to increased insight into the human genome, including how challenging it is to interpret rare genetic variation. In some cases, the ability to detect genetic mutations exceeds the ability to understand their clinical impact, limiting the advantage of these technologies. Obstacles in genomic medicine are many and include: understanding the level of certainty/uncertainty behind pathogenicity determination, the numerous different variant interpretation-guidelines used by clinical laboratories, delivering the certain or uncertain result to the patient, helping patients evaluate medical decisions in light of uncertainty regarding the consequence of the findings...
June 6, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28498655/discovery-of-an-orally-bioavailable-benzimidazole-diacylglycerol-acyltransferase-1-dgat1-inhibitor-that-suppresses-body-weight-gain-in-diet-induced-obese-dogs-and-postprandial-triglycerides-in-humans
#6
RANDOMIZED CONTROLLED TRIAL
Katsumasa Nakajima, Ricardo Chatelain, Kevin B Clairmont, Renee Commerford, Gary M Coppola, Thomas Daniels, Cornelia J Forster, Thomas A Gilmore, Yongjin Gong, Monish Jain, Aaron Kanter, Youngshin Kwak, Jingzhou Li, Charles D Meyers, Alan D Neubert, Paul Szklennik, Vivienne Tedesco, James Thompson, David Truong, Qing Yang, Brian K Hubbard, Michael H Serrano-Wu
Modification of a gut restricted class of benzimidazole DGAT1 inhibitor 1 led to 9 with good oral bioavailability. The key structural changes to 1 include bioisosteric replacement of the amide with oxadiazole and α,α-dimethylation of the carboxylic acid, improving DGAT1 potency and gut permeability. Since DGAT1 is expressed in the small intestine, both 1 and 9 can suppress postprandial triglycerides during acute oral lipid challenges in rats and dogs. Interestingly, only 9 was found to be effective in suppressing body weight gain relative to control in a diet-induced obese dog model, suggesting the importance of systemic inhibition of DGAT1 for body weight control...
June 8, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28472486/re-operation-after-long-segment-fusions-for-adult-spinal-deformity-the-impact-of-extending-the-construct-below-the-lumbar-spine
#7
Christopher D Witiw, Richard G Fessler, Stacie Nguyen, Praveen Mummaneni, Neel Anand, Donald Blaskiewicz, Juan Uribe, Michael Y Wang, Adam S Kanter, David Okonkwo, Paul Park, Vedat Deviren, Behrooz A Akbarnia, Robert K Eastlack, Christopher Shaffrey, Gregory M Mundis
BACKGROUND: Deciding where to end a long-segment fusion for adult spinal deformity (ASD) may be a challenge, particularly in the absence of an abnormality at L5/S1. Some suggest prophylactic extension of the construct to the sacrum and/or ilium (S/I) to protect against distal junctional failure, while others support terminating in the lower lumbar spine to preserve motion. OBJECTIVE: To compare the risk of re-operation after long-segment fusions for ASD that ends at L4 or L5 (L4/5) vs S/I...
May 3, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28451498/a-multicenter-review-of-superior-laryngeal-nerve-injury-following-anterior-cervical-spine-surgery
#8
Zachary J Tempel, Justin S Smith, Christopher Shaffrey, Paul M Arnold, Michael G Fehlings, Thomas E Mroz, K Daniel Riew, Adam S Kanter
STUDY DESIGN: A retrospective multicenter case-series study; case report and review of the literature. OBJECTIVE: The anatomy and function of the superior laryngeal nerve (SLN) are well described; however, the consequences of SLN injury remain variable and poorly defined. The prevalence of SLN injury as a consequence of cervical spine surgery is difficult to discern as its clinical manifestations are often inconstant and frequently of a subclinical degree. A multicenter study was performed to better delineate the risk factors, prevalence, and outcomes of SLN injury...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28451493/a-multicenter-study-of-the-presentation-treatment-and-outcomes-of-cervical-dural-tears
#9
Kevin R O'Neill, Michael G Fehlings, Thomas E Mroz, Zachary A Smith, Wellington K Hsu, Adam S Kanter, Michael P Steinmetz, Paul M Arnold, Praveen V Mummaneni, Dean Chou, Ahmad Nassr, Sheeraz A Qureshi, Samuel K Cho, Evan O Baird, Justin S Smith, Christopher Shaffrey, Chadi A Tannoury, Tony Tannoury, Ziya L Gokaslan, Jeffrey L Gum, Robert A Hart, Robert E Isaacs, Rick C Sasso, David B Bumpass, Mohamad Bydon, Mark Corriveau, Anthony F De Giacomo, Adeeb Derakhshan, Bruce C Jobse, Daniel Lubelski, Sungho Lee, Eric M Massicotte, Jonathan R Pace, Gabriel A Smith, Khoi D Than, K Daniel Riew
STUDY DESIGN: Retrospective multicenter case series study. OBJECTIVE: Because cervical dural tears are rare, most surgeons have limited experience with this complication. A multicenter study was performed to better understand the presentation, treatment, and outcomes following cervical dural tears. METHODS: Multiple surgeons from 23 institutions retrospectively identified 21 rare complications that occurred between 2005 and 2011, including unintentional cervical dural tears...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28451489/hypoglossal-nerve-palsy-after-cervical-spine-surgery
#10
Christopher P Ames, Aaron J Clark, Adam S Kanter, Paul M Arnold, Michael G Fehlings, Thomas E Mroz, K Daniel Riew
STUDY DESIGN: Multi-institutional retrospective study. OBJECTIVE: The goal of the current study is to quantify the incidence of 2 extremely rare complications of cervical spine surgery; hypoglossal and glossopharyngeal nerve palsies. METHODS: A total of 8887 patients who underwent cervical spine surgery from 2005 to 2011 were included in the study from 21 institutions. RESULTS: No glossopharyngeal nerve injuries were reported...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28451483/epidural-hematoma-following-cervical-spine-surgery
#11
Gregory D Schroeder, Alan S Hilibrand, Paul M Arnold, David E Fish, Jeffrey C Wang, Jeffrey L Gum, Zachary A Smith, Wellington K Hsu, Ziya L Gokaslan, Robert E Isaacs, Adam S Kanter, Thomas E Mroz, Ahmad Nassr, Rick C Sasso, Michael G Fehlings, Zorica Buser, Mohamad Bydon, Peter I Cha, Dhananjay Chatterjee, Erica L Gee, Elizabeth L Lord, Erik N Mayer, Owen J McBride, Emily C Nguyen, Allison K Roe, P Justin Tortolani, D Alex Stroh, Marisa Y Yanez, K Daniel Riew
STUDY DESIGN: A multicentered retrospective case series. OBJECTIVE: To determine the incidence and circumstances surrounding the development of a symptomatic postoperative epidural hematoma in the cervical spine. METHODS: Patients who underwent cervical spine surgery between January 1, 2005, and December 31, 2011, at 23 institutions were reviewed, and all patients who developed an epidural hematoma were identified. RESULTS: A total of 16 582 cervical spine surgeries were identified, and 15 patients developed a postoperative epidural hematoma, for a total incidence of 0...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28451480/rare-complications-of-cervical-spine-surgery-horner-s-syndrome
#12
Vincent C Traynelis, Hani R Malone, Zachary A Smith, Wellington K Hsu, Adam S Kanter, Sheeraz A Qureshi, Samuel K Cho, Evan O Baird, Robert E Isaacs, Ra'Kerry K Rahman, Galina Polevaya, Justin S Smith, Christopher Shaffrey, P Justin Tortolani, D Alex Stroh, Paul M Arnold, Michael G Fehlings, Thomas E Mroz, K Daniel Riew
STUDY DESIGN: A multicenter retrospective case series. OBJECTIVE: Horner's syndrome is a known complication of anterior cervical spinal surgery, but it is rarely encountered in clinical practice. To better understand the incidence, risks, and neurologic outcomes associated with Horner's syndrome, a multicenter study was performed to review a large collective experience with this rare complication. METHODS: We conducted a retrospective multicenter case series study involving 21 high-volume surgical centers from the AOSpine North America Clinical Research Network...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28437339/a-multicenter-evaluation-of-clinical-and-radiographic-outcomes-following-high-grade-spondylolisthesis-reduction-and-fusion
#13
Gurpreet S Gandhoke, Manish K Kasliwal, Justin S Smith, JoAnne Nieto, David Ibrahimi, Paul Park, Frank Lamarca, Christopher Shaffrey, David O Okonkwo, Adam S Kanter
OBJECTIVE: A retrospective review of the clinical and radiographic outcomes from a multicenter study of surgical treatment for high-grade spondylolisthesis (HGS) in adults. The objective was to assess the safety of surgical reduction, its ability to correct regional deformity, and its clinical effectiveness. METHODS: Retrospective, multicenter review of adults (age above 18 y) with lumbosacral HGS (Meyerding grade 3-5) treated surgically with open decompression, attempted reduction, posterior instrumentation, and interbody fusion...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28402485/evolution-of-sagittal-imbalance-following-corrective-surgery-for-sagittal-plane-deformity
#14
Michael M McDowell, Zachary J Tempel, Gurpreet S Gandhoke, Nicholas K Khattar, D Kojo Hamilton, Adam S Kanter, David O Okonkwo
BACKGROUND: Sagittal balance in adult spinal deformity is a major predictor of quality of life. A temporary loss of paraspinal muscle force and somatic pain following spine surgery may limit a patient's ability to maintain posture. OBJECTIVE: To assess the evolution of sagittal balance and clinical outcomes during recovery from adult spinal deformity surgery. METHODS: Retrospective review of a prospective observational database identified a consecutive series of patients with sagittal vertical axis (SVA) > 40 mm undergoing adult deformity surgery...
July 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28402458/the-influence-of-pelvic-incidence-and-lumbar-lordosis-mismatch-on-development-of-symptomatic-adjacent-level-disease-following-single-level-transforaminal-lumbar-interbody-fusion
#15
Zachary J Tempel, Gurpreet S Gandhoke, Bryan D Bolinger, Nicolas K Khattar, Philip V Parry, Yue-Fang Chang, David O Okonkwo, Adam S Kanter
BACKGROUND: Annual incidence of symptomatic adjacent level disease (ALD) following lumbar fusion surgery ranges from 0.6% to 3.9% per year. Sagittal malalignment may contribute to the development of ALD. OBJECTIVE: To describe the relationship between pelvic incidence-lumbar lordosis (PI-LL) mismatch and the development of symptomatic ALD requiring revision surgery following single-level transforaminal lumbar interbody fusion for degenerative lumbar spondylosis and/or low-grade spondylolisthesis...
June 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28400316/glucose-ingestion-causes-cardiac-repolarization-disturbances-in-type-1-long-qt-syndrome-patients-and-healthy-subjects
#16
Louise Hyltén-Cavallius, Eva W Iepsen, Michael Christiansen, Claus Graff, Allan Linneberg, Oluf Pedersen, Jens J Holst, Torben Hansen, Signe S Torekov, Jørgen K Kanters
BACKGROUND: Both hypoglycemia and severe hyperglycemia constitute known risk factors for cardiac repolarization changes potentially leading to malignant arrhythmias. Patients with loss of function mutations in KCNQ1 are characterized by long QT syndrome (LQTS) and may be at increased risk for glucose-induced repolarization disturbances. OBJECTIVE: The purpose of this study was to test the hypothesis that KCNQ1 LQTS patients are at particular risk for cardiac repolarization changes during the relative hyperglycemia that occurs after an oral glucose load...
April 9, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28379579/discovery-of-novel-heart-rate-associated-loci-using-the-exome-chip
#17
Marten E van den Berg, Helen R Warren, Claudia P Cabrera, Niek Verweij, Borbala Mifsud, Jeffrey Haessler, Nathan A Bihlmeyer, Yi-Ping Fu, Stefan Weiss, Henry J Lin, Niels Grarup, Ruifang Li-Gao, Giorgio Pistis, Nabi Shah, Jennifer A Brody, Martina Müller-Nurasyid, Honghuang Lin, Hao Mei, Albert V Smith, Leo-Pekka Lyytikäinen, Leanne M Hall, Jessica van Setten, Stella Trompet, Bram P Prins, Aaron Isaacs, Farid Radmanesh, Jonathan Marten, Aiman Entwistle, Jan A Kors, Claudia T Silva, Alvaro Alonso, Joshua C Bis, Rudolf de Boer, Hugoline G de Haan, Renée de Mutsert, George Dedoussis, Anna F Dominiczak, Alex S F Doney, Patrick T Ellinor, Ruben N Eppinga, Stephan B Felix, Xiuqing Guo, Yanick Hagemeijer, Torben Hansen, Tamara B Harris, Susan R Heckbert, Paul L Huang, Shih-Jen Hwang, Mika Kähönen, Jørgen K Kanters, Ivana Kolcic, Lenore J Launer, Man Li, Jie Yao, Allan Linneberg, Simin Liu, Peter W Macfarlane, Massimo Mangino, Andrew D Morris, Antonella Mulas, Alison D Murray, Christopher P Nelson, Marco Orrú, Sandosh Padmanabhan, Annette Peters, David J Porteous, Neil Poulter, Bruce M Psaty, Lihong Qi, Olli T Raitakari, Fernando Rivadeneira, Carolina Roselli, Igor Rudan, Naveed Sattar, Peter Sever, Moritz F Sinner, Elsayed Z Soliman, Timothy D Spector, Alice V Stanton, Kathleen E Stirrups, Kent D Taylor, Martin D Tobin, André Uitterlinden, Ilonca Vaartjes, Arno W Hoes, Peter van der Meer, Uwe Völker, Melanie Waldenberger, Zhijun Xie, Magdalena Zoledziewska, Andrew Tinker, Ozren Polasek, Jonathan Rosand, Yalda Jamshidi, Cornelia M van Duijn, Eleftheria Zeggini, J Wouter Jukema, Folkert W Asselbergs, Nilesh J Samani, Terho Lehtimäki, Vilmundur Gudnason, James Wilson, Steven A Lubitz, Stefan Kääb, Nona Sotoodehnia, Mark J Caulfield, Colin N A Palmer, Serena Sanna, Dennis O Mook-Kanamori, Panos Deloukas, Oluf Pedersen, Jerome I Rotter, Marcus Dörr, Chris J O'Donnell, Caroline Hayward, Dan E Arking, Charles Kooperberg, Pim van der Harst, Mark Eijgelsheim, Bruno H Stricker, Patricia B Munroe
Resting heart rate is a heritable trait, and an increase in heart rate is associated with increased mortality risk. Genome-wide association study analyses have found loci associated with resting heart rate, at the time of our study these loci explained 0.9% of the variation. This study aims to discover new genetic loci associated with heart rate from Exome Chip meta-analyses.Heart rate was measured from either elecrtrocardiograms or pulse recordings. We meta-analysed heart rate association results from 104 452 European-ancestry individuals from 30 cohorts, genotyped using the Exome Chip...
June 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28260410/the-effects-of-organizational-commitment-and-structural-empowerment-on-patient-safety-culture
#18
Sujin K Horwitz, Irwin B Horwitz
Purpose The purpose of this paper is to investigate the relationship between patient safety culture and two attitudinal constructs: affective organizational commitment and structural empowerment. In doing so, the main and interaction effects of the two constructs on the perception of patient safety culture were assessed using a cohort of physicians. Design/methodology/approach Affective commitment was measured with the Organizational Commitment Questionnaire, whereas structural empowerment was assessed with the Conditions of Work Effectiveness Questionnaire-II...
March 20, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/28235848/patients-with-long-qt-syndrome-caused-by-impaired-herg-encoded-kv11-1-potassium-channel-have-exaggerated-endocrine-pancreatic-and-incretin-function-associated-with-reactive-hypoglycemia
#19
Louise Hyltén-Cavallius, Eva W Iepsen, Nicolai J Wewer Albrechtsen, Mathilde Svendstrup, Anniek F Lubberding, Bolette Hartmann, Thomas Jespersen, Allan Linneberg, Michael Christiansen, Henrik Vestergaard, Oluf Pedersen, Jens J Holst, Jørgen K Kanters, Torben Hansen, Signe S Torekov
BACKGROUND: Loss-of-function mutations in hERG (encoding the Kv11.1 voltage-gated potassium channel) cause long-QT syndrome type 2 (LQT2) because of prolonged cardiac repolarization. However, Kv11.1 is also present in pancreatic α and β cells and intestinal L and K cells, secreting glucagon, insulin, and the incretins glucagon-like peptide-1 (GLP-1) and GIP (glucose-dependent insulinotropic polypeptide), respectively. These hormones are crucial for glucose regulation, and long-QT syndrome may cause disturbed glucose regulation...
May 2, 2017: Circulation
https://www.readbyqxmd.com/read/28158428/the-clinical-and-genetic-spectrum-of-catecholaminergic-polymorphic-ventricular-tachycardia-findings-from-an-international-multicentre-registry
#20
Thomas M Roston, Zhiguang Yuchi, Prince J Kannankeril, Julie Hathaway, Jeffrey M Vinocur, Susan P Etheridge, James E Potts, Kathleen R Maginot, Jack C Salerno, Mitchell I Cohen, Robert M Hamilton, Andreas Pflaumer, Saira Mohammed, Lynn Kimlicka, Ronald J Kanter, Martin J LaPage, Kathryn K Collins, Roman A Gebauer, Joel D Temple, Anjan S Batra, Christopher Erickson, Maria Miszczak-Knecht, Peter Kubuš, Yaniv Bar-Cohen, Michal Kantoch, Vincent C Thomas, Gabriele Hessling, Chris Anderson, Ming-Lon Young, Sally H J Choi, Michel Cabrera Ortega, Yung R Lau, Christopher L Johnsrude, Anne Fournier, Filip Van Petegem, Shubhayan Sanatani
No abstract text is available yet for this article.
January 31, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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