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K Kanter

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https://www.readbyqxmd.com/read/27894294/appropriate-threshold-levels-of-cardiac-beat-to-beat-variation-in-semi-automatic-analysis-of-equine-ecg-recordings
#1
Mette Flethøj, Jørgen K Kanters, Philip J Pedersen, Maria M Haugaard, Helena Carstensen, Lisbeth H Olsen, Rikke Buhl
BACKGROUND: Although premature beats are a matter of concern in horses, the interpretation of equine ECG recordings is complicated by a lack of standardized analysis criteria and a limited knowledge of the normal beat-to-beat variation of equine cardiac rhythm. The purpose of this study was to determine the appropriate threshold levels of maximum acceptable deviation of RR intervals in equine ECG analysis, and to evaluate a novel two-step timing algorithm by quantifying the frequency of arrhythmias in a cohort of healthy adult endurance horses...
November 28, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27798211/daclatasvir-30-mg-day-is-the-correct-dose-for-patients-taking-atazanavir-cobicistat
#2
E J Smolders, E P H Colbers, C T M M de Kanter, K Velthoven-Graafland, J P H Drenth, D M Burger
BACKGROUND: Atazanavir is boosted with the cytochrome P450 (CYP) 3A4 inhibitor ritonavir. When combined with the CYP3A4 substrate daclatasvir, the daclatasvir dosage should be reduced from 60 to 30 mg once daily. Recently, cobicistat was licensed as a CYP3A booster and used with atazanavir. OBJECTIVES: To determine whether the fixed-dose combination of atazanavir/cobicistat has an influence on daclatasvir pharmacokinetics comparable to that of the separate agents atazanavir and ritonavir...
October 20, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27785856/minimal-t-wave-representation-and-its-use-in-the-assessment-of-drug-arrhythmogenicity
#3
Saeed Shakibfar, Claus Graff, Jørgen K Kanters, Jimmi Nielsen, Samuel Schmidt, Johannes J Struijk
BACKGROUND: Recently, numerous models and techniques have been developed for analyzing and extracting features from the T wave which could be used as biomarkers for drug-induced abnormalities. The majority of these techniques and algorithms use features that determine readily apparent characteristics of the T wave, such as duration, area, amplitude, and slopes. METHODS: In the present work the T wave was down-sampled to a minimal rate, such that a good reconstruction was still possible...
October 27, 2016: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/27744414/nursing-clinical-instructor-experiences-of-empowerment-in-rwanda-applying-kanter-s-and-spreitzer-s-theories
#4
Mary Thuss, Yolanda Babenko-Mould, Mary-Anne Andrusyszyn, Heather K S Laschinger
The purpose of this study was to explore Rwandan nursing clinical instructors' (CIs) experiences of structural and psychological empowerment. CIs play a vital role in students' development by facilitating learning in health care practice environments. Quality nursing education hinges on the CI's ability to enact a professional role. A descriptive qualitative method was used to obtain an understanding of CIs empowerment experiences in practice settings. Kanter's Theory of Structural Power in Organizations and Spreitzer's Psychological Empowerment Theory were used as theoretical frameworks to interpret experiences...
October 15, 2016: International Journal of Nursing Education Scholarship
https://www.readbyqxmd.com/read/27726857/completeness-and-accuracy-of-local-clinical-registry-data-for-children-undergoing-heart-surgery
#5
Meena Nathan, Marshall L Jacobs, J William Gaynor, Jane W Newburger, Carolyn Dunbar Masterson, Linda M Lambert, Danielle Hollenbeck-Pringle, Felicia L Trachtenberg, Owen White, Brett R Anderson, Margaret C Bell, Phillip T Burch, Eric M Graham, Jonathan R Kaltman, Kirk R Kanter, Carlos M Mery, Christian Pizarro, Marcus S Schamberger, Michael D Taylor, Jeffrey P Jacobs, Sara K Pasquali
BACKGROUND: Data routinely captured in clinical registries may be leveraged to enhance efficiency of prospective research. The quality of registry data for this purpose has not been studied, however. We evaluated the completeness and accuracy of perioperative data within congenital heart centers' local surgical registries. METHODS: Within 12 Pediatric Heart Network (PHN) sites, we evaluated 31 perioperative variables (and their subcategories, totaling 113 unique fields) collected via sites' local clinical registries for submission to The Society of Thoracic Surgeons Database, compared with chart review by PHN research coordinators...
October 7, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27711072/numerous-brugada-syndrome-associated-genetic-variants-have-no-effect-on-j-point-elevation-syncope-susceptibility-malignant-cardiac-arrhythmia-and-all-cause-mortality
#6
Jonas Ghouse, Christian T Have, Morten W Skov, Laura Andreasen, Gustav Ahlberg, Jonas B Nielsen, Tea Skaaby, Søren-Peter Olesen, Niels Grarup, Allan Linneberg, Oluf Pedersen, Henrik Vestergaard, Stig Haunsø, Jesper H Svendsen, Torben Hansen, Jørgen K Kanters, Morten S Olesen
PURPOSE: We investigated whether Brugada syndrome (BrS)-associated variants identified in the general population have an effect on J-point elevation as well as whether carriers of BrS variants were more prone to experience syncope and malignant ventricular arrhythmia and had increased mortality compared with noncarriers. METHODS: All BrS-associated variants were identified using the Human Gene Mutation Database (HGMD). Individuals were randomly selected from a general population study using whole-exome sequencing data (n = 870) and genotype array data (n = 6,161) and screened for BrS-associated variants...
October 6, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/27566755/clinical-aspects-of-type-3-long-qt-syndrome-an-international-multicenter-study
#7
Arthur A M Wilde, Arthur J Moss, Elizabeth S Kaufman, Wataru Shimizu, Derick R Peterson, Jesaia Benhorin, Coeli Lopes, Jeffrey A Towbin, Carla Spazzolini, Lia Crotti, Wojciech Zareba, Ilan Goldenberg, Jørgen K Kanters, Jennifer L Robinson, Ming Qi, Nynke Hofman, David J Tester, Connie R Bezzina, Marielle Alders, Takeshi Aiba, Shiro Kamakura, Yoshihiro Miyamoto, Mark L Andrews, Scott McNitt, Bronislava Polonsky, Peter J Schwartz, Michael J Ackerman
BACKGROUND: Risk stratification in patients with type 3 long-QT syndrome (LQT3) by clinical and genetic characteristics and effectiveness of β-blocker therapy has not been studied previously in a large LQT3 population. METHODS: The study population included 406 LQT3 patients with 51 sodium channel mutations; 391 patients were known to be event free during the first year of life and were the focus of our study. Clinical, electrocardiographic, and genetic parameters were acquired for patients from 7 participating LQT3 registries...
September 20, 2016: Circulation
https://www.readbyqxmd.com/read/27527079/integrating-qualitative-research-methods-into-care-improvement-efforts-within-a-learning-health-system-addressing-antibiotic-overuse
#8
Corrine E Munoz-Plaza, Carla Parry, Erin E Hahn, Tania Tang, Huong Q Nguyen, Michael K Gould, Michael H Kanter, Adam L Sharp
BACKGROUND: Despite reports advocating for integration of research into healthcare delivery, scant literature exists describing how this can be accomplished. Examples highlighting application of qualitative research methods embedded into a healthcare system are particularly needed. This article describes the process and value of embedding qualitative research as the second phase of an explanatory, sequential, mixed methods study to improve antibiotic stewardship for acute sinusitis. METHODS: Purposive sampling of providers for in-depth interviews improved understanding of unwarranted antibiotic prescribing and elicited stakeholder recommendations for improvement...
2016: Health Research Policy and Systems
https://www.readbyqxmd.com/read/27326972/a-multi-center-evaluation-of-clinical-and-radiographic-outcomes-following-high-grade-spondylolisthesis-reduction-and-fusion
#9
Gurpreet S Gandhoke, Manish K Kasliwal, Justin S Smith, JoAnne Nieto, David Ibrahimi, Paul Park, Frank Lamarca, Christopher Shaffrey, David O Okonkwo, Adam S Kanter
OBJECTIVE: A retrospective review of the clinical and radiographic outcomes from a multi-center study of surgical treatment for high-grade spondylolisthesis (HGS) in adults. The objective was to assess the safety of surgical reduction, its ability to correct regional deformity, and its clinical effectiveness. METHODS: Retrospective, multi-center review of adults (age >18 y) with lumbo-sacral HGS (Meyerding grade 3-5) treated surgically with open decompression, attempted reduction, posterior instrumentation and interbody fusion...
June 20, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27305095/left-ventricular-function-after-prolonged-exercise-in-equine-endurance-athletes
#10
M Flethøj, C C Schwarzwald, M M Haugaard, H Carstensen, J K Kanters, L H Olsen, R Buhl
BACKGROUND: Prolonged exercise in human athletes is associated with transient impairment of left ventricular (LV) function, known as cardiac fatigue. Cardiac effects of prolonged exercise in horses remain unknown. OBJECTIVES: To investigate the effects of prolonged exercise on LV systolic and diastolic function in horses. ANIMALS: Twenty-six horses competing in 120-160 km endurance rides. METHODS: Cross-sectional field study...
July 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27212390/hetero-site-specific-x-ray-pump-probe-spectroscopy-for-femtosecond-intramolecular-dynamics
#11
A Picón, C S Lehmann, C Bostedt, A Rudenko, A Marinelli, T Osipov, D Rolles, N Berrah, C Bomme, M Bucher, G Doumy, B Erk, K R Ferguson, T Gorkhover, P J Ho, E P Kanter, B Krässig, J Krzywinski, A A Lutman, A M March, D Moonshiram, D Ray, L Young, S T Pratt, S H Southworth
New capabilities at X-ray free-electron laser facilities allow the generation of two-colour femtosecond X-ray pulses, opening the possibility of performing ultrafast studies of X-ray-induced phenomena. Particularly, the experimental realization of hetero-site-specific X-ray-pump/X-ray-probe spectroscopy is of special interest, in which an X-ray pump pulse is absorbed at one site within a molecule and an X-ray probe pulse follows the X-ray-induced dynamics at another site within the same molecule. Here we show experimental evidence of a hetero-site pump-probe signal...
2016: Nature Communications
https://www.readbyqxmd.com/read/27173073/early-extubation-after-repair-of-tetralogy-of-fallot-and-the-fontan-procedure-an-analysis-of-the-society-of-thoracic-surgeons-congenital-heart-surgery-database
#12
William T Mahle, Jeffrey P Jacobs, Marshall L Jacobs, Sunghee Kim, Paul M Kirshbom, Sara K Pasquali, Erle H Austin, Kirk R Kanter, Susan C Nicolson, Kevin D Hill
BACKGROUND: There is increasing interest in reducing the duration of mechanical ventilation after pediatric cardiac operations. However, the contemporary use of an early extubation strategy and its effect on clinical outcomes is poorly understood. METHODS: Data from The Society of Thoracic Surgeons Congenital Heart Surgery Database (2010 to 2013) were analyzed to determine the association of early extubation with postoperative length of stay (PLOS). Two operations were analyzed: complete repair of tetralogy of Fallot (TOF) in patients older than 45 days and the Fontan procedure...
September 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27102978/clinical-and-neuropsychiatric-correlates-of-lumbar-spinal-surgery-in-older-adults-results-of-a-pilot-study
#13
Jordan F Karp, Jonathan McGovern, Megan M Marron, Peter Gerszten, Debra K Weiner, David Okonkwo, Adam S Kanter
AIM: To improve selection of older lumbar surgical candidates, we surveyed correlates of functioning and satisfaction with surgery. MATERIALS & METHODS: Prospective sample at lumbar spine surgery clinic. Patients (n = 48) were evaluated before surgery and after 3 months. Dependent variables were functioning and surgical satisfaction. RESULTS: Baseline variables associated with disability at 3 months included cognitive status and widespread pain...
November 2016: Pain Management
https://www.readbyqxmd.com/read/27074612/changes-in-heart-rate-arrhythmia-frequency-and-cardiac-biomarker-values-in-horses-during-recovery-after-a-long-distance-endurance-ride
#14
Mette Flethøj, Jørgen K Kanters, Maria M Haugaard, Philip J Pedersen, Helena Carstensen, Johanne D Balling, Lisbeth H Olsen, Rikke Buhl
OBJECTIVE To evaluate heart rate, heart rate variability, and arrhythmia frequency as well as changes in cardiac biomarker values and their association with heart rate in horses before and after an endurance ride. DESIGN Cross-sectional study. ANIMALS 28 Arabian horses competing in a 120- or 160-km endurance ride. PROCEDURES ECG recordings were obtained from each horse before (preride) and after (recovery) an endurance ride to evaluate changes in heart rate and the SD of normal R-R intervals (SDNN) during the initial 12 hours of recovery...
May 1, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27071069/pediatric-triage-in-a-severe-pandemic-maximizing-survival-by-establishing-triage-thresholds
#15
Christine Gall, Randall Wetzel, Alexander Kolker, Robert K Kanter, Philip Toltzis
OBJECTIVES: To develop and validate an algorithm to guide selection of patients for pediatric critical care admission during a severe pandemic when Crisis Standards of Care are implemented. DESIGN: Retrospective observational study using secondary data. PATIENTS: Children admitted to VPS-participating PICUs between 2009-2012. INTERVENTIONS: A total of 111,174 randomly selected nonelective cases from the Virtual PICU Systems database were used to estimate each patient's probability of death and duration of ventilation employing previously derived predictive equations...
September 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27068842/differences-in-the-electrocardiographic-qt-interval-of-various-breeds-of-athletic-horses-during-rest-and-exercise
#16
P J Pedersen, M Karlsson, M Flethøj, D S Trachsel, J K Kanters, D A Klaerke, R Buhl
OBJECTIVES: Quantitative measurements of cardiac repolarization, defined as the electrocardiographic QT interval, have important diagnostic implications in humans, as irregularities can trigger potentially fatal ventricular tachyarrhythmia. In both humans and horses, cardiac repolarization is influenced to some extent by heart rate, age, body weight (BW), sex, autonomic tone, and environment. In horses, there is substantial inter-breed variation in size and training, and the aims of this study were therefore to determine the best model describing the QT to RR relationship in breeds of various athletic horses and to test for differences in the QT interval...
September 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/27057819/physician-professional-satisfaction-and-area-of-clinical-practice-evidence-from-an-integrated-health-care-delivery-system
#17
John P Caloyeras, Michael Kanter, Nicole Ives, Chong Y Kim, Hemal K Kanzaria, Sandra H Berry, Robert H Brook
CONTEXT: For health care reform to succeed, health care systems need a professionally satisfied primary care workforce. Evidence suggests that primary care physicians are less satisfied than those in other medical specialties. OBJECTIVE: To assess three domains of physician satisfaction by area of clinical practice among physicians practicing in an established integrated health system. DESIGN: Cross-sectional online survey of all Southern California Permanente Medical Group (SCPMG) partner and associate physicians (N = 1034) who were primarily providing clinic-based care in 1 of 4 geographically and operationally distinct Kaiser Permanente Southern California Medical Centers...
2016: Permanente Journal
https://www.readbyqxmd.com/read/26937118/tilt-table-testing-of-patients-with-pacemaker-and-recurrent-syncope
#18
Christian Haarmark, Jørgen K Kanters, Jesper Mehlsen
The diagnosis of recurrent syncope in patients with pacemakers (PM) is quite challenging and the etiology of syncope is often multifactorial. To portray the mechanism of syncope in PM patients, we report the results of head-up tilt table testing (HUT) in a series of patients with PM, originally implanted for reasons other than neurally mediated syncope, referred due to syncope or pre-syncope (aborted syncope, vertigo, suspected orthostatic hypotension). Forty-one patients with PM undergoing a HUT in our syncope unit between January 1st, 2007 and December 31st 2011 were included...
July 2015: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/26925492/major-rapid-weight-loss-induces-changes-in-cardiac-repolarization
#19
Esben Vedel-Larsen, Eva Winning Iepsen, Julie Lundgren, Claus Graff, Johannes J Struijk, Torben Hansen, Jens Juul Holst, Sten Madsbad, Signe Torekov, Jørgen K Kanters
INTRODUCTION: Obesity is associated with increased all-cause mortality, but weight loss may not decrease cardiovascular events. In fact, very low calorie diets have been linked to arrhythmias and sudden death. The QT interval is the standard marker for cardiac repolarization, but T-wave morphology analysis has been suggested as a more sensitive method to identify changes in cardiac repolarization. We examined the effect of a major and rapid weight loss on T-wave morphology. METHODS AND RESULTS: Twenty-six individuals had electrocardiograms (ECG) taken before and after eight weeks of weight loss intervention along with plasma measurements of fasting glucose, HbA1c, and potassium...
May 2016: Journal of Electrocardiology
https://www.readbyqxmd.com/read/26826751/the-online-personal-action-plan-a-tool-to-transform-patient-enabled-preventive-and-chronic-care
#20
Shayna L Henry, Ernest Shen, Andre Ahuja, Michael K Gould, Michael H Kanter
INTRODUCTION: Patient-facing online tools for managing preventive and chronic care can be a resource-effective way to increase patient agency in health promotion. Recently, Kaiser Permanente Southern California added the Online Personal Action Plan (oPAP) to the member web portal to better enable members to access information about prevention, health promotion, and care gaps. This study described Kaiser Permanente Southern California members who use oPAP, as well as how members use oPAP to close five different care gaps: hemoglobin A1c testing, pneumonia vaccination, and three cancer screenings...
July 2016: American Journal of Preventive Medicine
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