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https://www.readbyqxmd.com/read/29311162/differential-expression-and-remodeling-of-transient-outward-potassium-currents-in-human-left-ventricles
#1
Eric K Johnson, Steven J Springer, Wei Wang, Edward J Dranoff, Yan Zhang, Evelyn M Kanter, Kathryn A Yamada, Jeanne M Nerbonne
BACKGROUND: Myocardial, transient, outward currents, Ito, have been shown to play pivotal roles in action potential (AP) repolarization and remodeling in animal models. The properties and contribution of Ito to left ventricular (LV) repolarization in the human heart, however, are poorly defined. METHODS AND RESULTS: Whole-cell, voltage-clamp recordings, acquired at physiological (35°C to 37°C) temperatures, from myocytes isolated from the LV of nonfailing human hearts identified 2 distinct transient currents, Ito,fast (Ito,f) and Ito,slow (Ito,s), with significantly (P<0...
January 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29194939/management-of-drug-interactions-with-direct-acting-antivirals-in-dutch-hiv-hepatitis-c-virus-coinfected-patients-adequate-but-not-perfect
#2
E J Smolders, C Smit, Ctmm de Kanter, Asm Dofferhoff, J E Arends, K Brinkman, B Rijnders, M van der Valk, P Reiss, D M Burger
OBJECTIVES: Direct-acting antivirals (DAAs) for treatment of chronic hepatitis C virus (HCV) infection can cause drug-drug interactions (DDIs) with combination antiretroviral therapy (cART) and non-cART co-medication. We mapped how physicians manage DDIs between DAAs and co-medication and analysed treatment outcomes. METHODS: Data were prospectively collected as part of the ATHENA HIV observational cohort and retrospectively analysed. Dutch patients with HIV/HCV coinfection who initiated treatment with DAAs between January 2015 and May 2016 were included...
December 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29191102/impact-of-case-type-length-of-stay-institution-type-and-comorbidities-on-medicare-diagnosis-related-group-reimbursement-for-adult-spinal-deformity-surgery
#3
Pierce D Nunley, Gregory M Mundis, Richard G Fessler, Paul Park, Joseph M Zavatsky, Juan S Uribe, Robert K Eastlack, Dean Chou, Michael Y Wang, Neel Anand, Kelly A Frank, Marcus B Stone, Adam S Kanter, Christopher I Shaffrey, Praveen V Mummaneni
OBJECTIVE The aim of this study was to educate medical professionals about potential financial impacts of improper diagnosis-related group (DRG) coding in adult spinal deformity (ASD) surgery. METHODS Medicare's Inpatient Prospective Payment System PC Pricer database was used to collect 2015 reimbursement data for ASD procedures from 12 hospitals. Case type, hospital type/location, number of operative levels, proper coding, length of stay, and complications/comorbidities (CCs) were analyzed for effects on reimbursement...
December 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29191098/complication-rates-associated-with-open-versus-percutaneous-pedicle-screw-instrumentation-among-patients-undergoing-minimally-invasive-interbody-fusion-for-adult-spinal-deformity
#4
Khoi D Than, Praveen V Mummaneni, Kelly J Bridges, Stacie Tran, Paul Park, Dean Chou, Frank La Marca, Juan S Uribe, Todd D Vogel, Pierce D Nunley, Robert K Eastlack, Neel Anand, David O Okonkwo, Adam S Kanter, Gregory M Mundis
OBJECTIVE High-quality studies that compare outcomes of open and minimally invasively placed pedicle screws for adult spinal deformity are needed. Therefore, the authors compared differences in complications from a circumferential minimally invasive spine (MIS) surgery and those from a hybrid surgery. METHODS A retrospective review of a multicenter database of patients with spinal deformity who were treated with an MIS surgery was performed. Database inclusion criteria included an age of ≥ 18 years and at least 1 of the following: a coronal Cobb angle of > 20°, a sagittal vertical axis of > 5 cm, a pelvic incidence-lumbar lordosis angle of > 10°, and/or a pelvic tilt of > 20°...
December 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29182356/improving-antibiotic-stewardship-a-stepped-wedge-cluster-randomized-trial
#5
Adam L Sharp, Yi R Hu, Ernest Shen, Richard Chen, Ryan P Radecki, Michael H Kanter, Michael K Gould
OBJECTIVES: Antibiotic stewardship is key to optimizing patient outcomes and affordable care. The study objective was to examine the effect of provider education and clinical decision support (CDS) on antibiotic prescribing for acute sinusitis among providers of varying experience. STUDY DESIGN: A stepped-wedge cluster randomized intervention to evaluate antibiotic use for acute sinusitis encounters at 126 Kaiser Permanente Southern California clinics between September 2014 and April 2015...
November 1, 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29128143/influence-of-type-of-sport-on-cardiac-repolarization-assessed-by-electrocardiographic-t-wave-morphology-combination-score
#6
Susanne Glasius Tischer, Claus Graff, Christina Ellervik, Eva Prescott, Jørgen K Kanters, Hanne Kruuse Rasmusen
INTRODUCTION: Interpreting repolarization changes in the electrocardiograms of athletes present a clinical challenge. AIM: Assessment of cardiac repolarization by T-wave morphology using the Morphology Combination Score (MCS), and evaluate how this quantitative description of T-wave morphology was influenced by the sport performed. MATERIALS AND METHODS: Digital electrocardiograms of 469 young elite athletes were analyzed for T-wave asymmetry, flatness and notching, and combined in the MCS...
September 29, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29097701/two-missense-mutations-in-kcnq1-cause-pituitary-hormone-deficiency-and-maternally-inherited-gingival-fibromatosis
#7
Johanna Tommiska, Johanna Känsäkoski, Lasse Skibsbye, Kirsi Vaaralahti, Xiaonan Liu, Emily J Lodge, Chuyi Tang, Lei Yuan, Rainer Fagerholm, Jørgen K Kanters, Päivi Lahermo, Mari Kaunisto, Riikka Keski-Filppula, Sanna Vuoristo, Kristiina Pulli, Tapani Ebeling, Leena Valanne, Eeva-Marja Sankila, Sirpa Kivirikko, Mitja Lääperi, Filippo Casoni, Paolo Giacobini, Franziska Phan-Hug, Tal Buki, Manuel Tena-Sempere, Nelly Pitteloud, Riitta Veijola, Marita Lipsanen-Nyman, Kari Kaunisto, Patrice Mollard, Cynthia L Andoniadou, Joel A Hirsch, Markku Varjosalo, Thomas Jespersen, Taneli Raivio
Familial growth hormone deficiency provides an opportunity to identify new genetic causes of short stature. Here we combine linkage analysis with whole-genome resequencing in patients with growth hormone deficiency and maternally inherited gingival fibromatosis. We report that patients from three unrelated families harbor either of two missense mutations, c.347G>T p.(Arg116Leu) or c.1106C>T p.(Pro369Leu), in KCNQ1, a gene previously implicated in the long QT interval syndrome. Kcnq1 is expressed in hypothalamic GHRH neurons and pituitary somatotropes...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29081908/utility-and-correlation-of-known-anticoagulation-parameters-in-the-management-of-pediatric-ventricular-assist-devices
#8
Ajay K Bhatia, Mouhammad Yabrodi, Mallory Carroll, Silvia Bunting, Kirk Kanter, Kevin O Maher, Shriprasad R Deshpande
AIM: To assess utility and correlation of known anticoagulation parameters in the management of pediatric ventricular assist device (VAD). METHODS: Retrospective study of pediatric patients supported with a Berlin EXCOR VAD at a single pediatric tertiary care center during a single year. RESULTS: We demonstrated associations between activated thromboplastin time (aPTT) and R-thromboelastography (R-TEG) values (rs = 0.65, P < 0.001) and between anti-Xa assay and R-TEG values (rs = 0...
September 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/29068807/antiarrhythmic-effects-of-combining-dofetilide-and-ranolazine-in-a-model-of-acutely-induced-atrial-fibrillation-in-horses
#9
Helena Carstensen, Line Kjær, Maria Mathilde Haugaard, Mette Flethøj, Eva Zander Hesselkilde, Jørgen K Kanters, Steen Pehrson, Rikke Buhl, Thomas Jespersen
BACKGROUND: Antiarrhythmic compounds against atrial fibrillation (AF) often have reduced efficacy and may display cardiac and/or non-cardiac toxicity. Efficacy can be improved by combining two compounds with distinct mechanisms, and it may be possible to use lower doses of each compound, thereby reducing the likelihood of adverse side-effects. The purpose of this study was to investigate whether the effective doses of dofetilide and ranolazine can be reduced if the drugs are combined...
October 25, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28989851/is-there-a-patient-profile-that-characterizes-a-patient-with-adult-spinal-deformity-as-a-candidate-for-minimally-invasive-surgery
#10
Robert K Eastlack, Gregory M Mundis, Michael Wang, Praveen V Mummaneni, Juan Uribe, David Okonkwo, Behrooz A Akbarnia, Neel Anand, Adam Kanter, Paul Park, Virginie Lafage, Christopher Shaffrey, Richard Fessler, Vedat Deviren
STUDY DESIGN: Retrospective review. OBJECTIVES: The goal of this study was to evaluate the baseline characteristics of patients chosen to undergo traditional open versus minimally invasive surgery (MIS) for adult spinal deformity (ASD). METHODS: A multicenter review of 2 databases including ASD patients treated with surgery. Inclusion criteria were age >45 years, Cobb angle minimum of 20°, and minimum 2-year follow-up. Preoperative radiographic parameters and disability outcome measures were reviewed...
October 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28945896/patients-with-high-pelvic-tilt-achieve-the-same-clinical-success-as-those-with-low-pelvic-tilt-after-minimally-invasive-adult-deformity-surgery
#11
Juan S Uribe, Jacob Januszewski, Michael Wang, Neel Anand, David O Okonkwo, Praveen V Mummaneni, Stacie Nguyen, Joseph Zavatsky, Khoi Than, Pierce Nunley, Paul Park, Adam S Kanter, Frank La Marca, Richard Fessler, Gregory M Mundis, Robert K Eastlack
BACKGROUND: Pelvic tilt (PT) is a compensatory mechanism for adult spinal deformity patients to mitigate sagittal imbalance. The association between preop PT and postop clinical and radiographic outcomes has not been well studied in patients undergoing minimally invasive adult deformity surgery. OBJECTIVE: To evaluate clinical and radiographic outcomes in adult spinal deformity patients with high and low preoperative PT treated surgically using less invasive techniques...
August 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28940299/a-history-of-drug-induced-torsades-de-pointes-is-associated-with-t-wave-morphological-abnormalities
#12
Tanveer A Bhuiyan, Claus Graff, Jørgen K Kanters, Jacob Melgaard, Egon Toft, Stefan Kääb, Johannes J Struijk
The hypothesis of the study is that TdP history can be better identified using T-wave morphology compared to QTcF at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The Fridericia-corrected QT interval (QTcF) and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446±9 ms; -TdP: QTcF = 431±9 ms, p = 0...
September 22, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28939174/ventricular-repolarization-alterations-in-women-with-angina-pectoris-and-suspected-coronary-microvascular-dysfunction
#13
Nynne Dose, Marie Mide Michelsen, Naja Dam Mygind, Adam Pena, Christina Ellervik, Peter R Hansen, Jørgen K Kanters, Eva Prescott, Jens Kastrup, Ida Gustafsson, Henrik Steen Hansen
OBJECTIVES: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD. METHODS: Women with angina pectoris and no obstructive coronary artery disease (n=138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch...
August 17, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28938967/increasing-propensity-to-pursue-operative-closure-of-atrial-septal-defects-following-changes-in-the-instructions-for-use-of-the-amplatzer-septal-occluder-device-an-observational-study-using-data-from-the-pediatric-health-information-systems-database
#14
MULTICENTER STUDY
Michael L O'Byrne, Russell T Shinohara, Elena K Grant, Joshua P Kanter, Matthew J Gillespie, Yoav Dori, Jonathan J Rome, Andrew C Glatz
Concern for device erosion following transcatheter treatment of atrial septal defects (TC-ASD) led in 2012 to a United States Food and Drug Administration panel review and changes in the instructions for use of the Amplatzer Septal Occluder (ASO) device. No studies have assessed the effect of these changes on real-world practice. To this end a multicenter observational study was performed to evaluate trends in the treatment of ASD. METHODS: A retrospective observational study was performed using data from the Pediatric Health Information Systems database of all patients with isolated ASD undergoing either TC-ASD or operative ASD closure (O-ASD) from January 1, 2007, to September 30, 2015, hypothesizing that the propensity to pursue O-ASD increased beginning in 2013...
October 2017: American Heart Journal
https://www.readbyqxmd.com/read/28881031/ribavirin-steady-state-plasma-level-is-a-predictor-of-sustained-virological-response-in-hepatitis-c-infected-patients-treated-with-direct-acting-antivirals
#15
M van Tilborg, F I Lieveld, E J Smolders, K J van Erpecum, C T M M de Kanter, R Maan, M van der Valk, J E Arends, A S M Dofferhoff, H Blokzijl, M Bijmolen, J P H Drenth, R J de Knegt, D M Burger
BACKGROUND: In the era of highly effective direct-acting antivirals (DAAs) for treatment of patients with chronic hepatitis C virus (HCV) infection, ribavirin (RBV) is still considered beneficial in certain patients. AIM: To assess the association between RBV steady-state plasma levels and sustained virological response (SVR). METHODS: Consecutive HCV-infected patients treated with DAAs plus RBV from four Dutch academic medical centres were enrolled...
November 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28874164/radiation-free-cmr-diagnostic-heart-catheterization-in-children
#16
Kanishka Ratnayaka, Joshua P Kanter, Anthony Z Faranesh, Elena K Grant, Laura J Olivieri, Russell R Cross, Ileen F Cronin, Karin S Hamann, Adrienne E Campbell-Washburn, Kendall J O'Brien, Toby Rogers, Michael S Hansen, Robert J Lederman
BACKGROUND: Children with heart disease may require repeated X-Ray cardiac catheterization procedures, are more radiosensitive, and more likely to survive to experience oncologic risks of medical radiation. Cardiovascular magnetic resonance (CMR) is radiation-free and offers information about structure, function, and perfusion but not hemodynamics. We intend to perform complete radiation-free diagnostic right heart catheterization entirely using CMR fluoroscopy guidance in an unselected cohort of pediatric patients; we report the feasibility and safety...
September 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28739290/implementation-of-the-canadian-ct-head-rule-and-its-association-with-use-of-computed-tomography-among-patients-with-head-injury
#17
Adam L Sharp, Brian Z Huang, Tania Tang, Ernest Shen, Edward R Melnick, Arjun K Venkatesh, Michael H Kanter, Michael K Gould
STUDY OBJECTIVE: Approximately 1 in 3 computed tomography (CT) scans performed for head injury may be avoidable. We evaluate the association of implementation of the Canadian CT Head Rule on head CT imaging in community emergency departments (EDs). METHODS: We conducted an interrupted time-series analysis of encounters from January 2014 to December 2015 in 13 Southern California EDs. Adult health plan members with a trauma diagnosis and Glasgow Coma Scale score at ED triage were included...
July 21, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28667743/hidradenitis-suppurativa-and-electrocardiographic-changes-a-cross-sectional-population-study
#18
C R Juhl, I M Miller, G B Jemec, J K Kanters, C Ellervik
BACKGROUND: Hidradenitis Suppurativa (HS) is a chronic, inflammatory skin disease, recently associated with metabolic syndrome, subclinical atherosclerosis and increased risk of cardiovascular disease. OBJECTIVES: The aim of the study was to investigate the hitherto unknown electrocardiographic changes associated with HS, which recently have been associated with significant cardiovascular burden. METHODS: Data were derived from the cross-sectional population study, The Danish General Population Study (GESUS)...
July 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28589536/distinguishing-pathogenic-mutations-from-background-genetic-noise-in-cardiology-the-use-of-large-genome-databases-for-genetic-interpretation
#19
REVIEW
Jonas Ghouse, Morten W Skov, Robert S Bigseth, Gustav Ahlberg, Jørgen K Kanters, Morten S Olesen
Advances in clinical genetic testing has led to increased insight into the human genome, including how challenging it is to interpret rare genetic variation. In some cases, the ability to detect genetic mutations exceeds the ability to understand their clinical impact, limiting the advantage of these technologies. Obstacles in genomic medicine are many and include: understanding the level of certainty/uncertainty behind pathogenicity determination, the numerous different variant interpretation-guidelines used by clinical laboratories, delivering the certain or uncertain result to the patient, helping patients evaluate medical decisions in light of uncertainty regarding the consequence of the findings...
June 6, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28498655/discovery-of-an-orally-bioavailable-benzimidazole-diacylglycerol-acyltransferase-1-dgat1-inhibitor-that-suppresses-body-weight-gain-in-diet-induced-obese-dogs-and-postprandial-triglycerides-in-humans
#20
RANDOMIZED CONTROLLED TRIAL
Katsumasa Nakajima, Ricardo Chatelain, Kevin B Clairmont, Renee Commerford, Gary M Coppola, Thomas Daniels, Cornelia J Forster, Thomas A Gilmore, Yongjin Gong, Monish Jain, Aaron Kanter, Youngshin Kwak, Jingzhou Li, Charles D Meyers, Alan D Neubert, Paul Szklennik, Vivienne Tedesco, James Thompson, David Truong, Qing Yang, Brian K Hubbard, Michael H Serrano-Wu
Modification of a gut restricted class of benzimidazole DGAT1 inhibitor 1 led to 9 with good oral bioavailability. The key structural changes to 1 include bioisosteric replacement of the amide with oxadiazole and α,α-dimethylation of the carboxylic acid, improving DGAT1 potency and gut permeability. Since DGAT1 is expressed in the small intestine, both 1 and 9 can suppress postprandial triglycerides during acute oral lipid challenges in rats and dogs. Interestingly, only 9 was found to be effective in suppressing body weight gain relative to control in a diet-induced obese dog model, suggesting the importance of systemic inhibition of DGAT1 for body weight control...
June 8, 2017: Journal of Medicinal Chemistry
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