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JOURNAL ARTICLE
Jean-Philippe Kanter, Lars Milke, Judith K Metz, Ali Biabani, Hartmut Schlüter, Martin Gand, Jakob P Ley, Holger Zorn
Due to the increasing demand for natural food ingredients, including taste-active compounds, enzyme-catalyzed conversions of natural substrates, such as flavonoids, are promising tools to align with the principles of Green Chemistry. In this study, a novel O -methyltransferase activity was identified in the mycelium of Lentinula edodes , which was successfully applied to generate the taste-active flavonoids hesperetin, hesperetin dihydrochalcone, homoeriodictyol, and homoeriodictyol dihydrochalcone. Furthermore, the mycelium-mediated OMT activity allowed for the conversion of various catecholic substrates, yielding their respective (iso-)vanilloids, while monohydroxylated compounds were not converted...
May 3, 2024: Journal of Agricultural and Food Chemistry
#2
JOURNAL ARTICLE
Jonas L Isaksen, Christian B Sivertsen, Christian Zinck Jensen, Claus Graff, Dominik Linz, Christina Ellervik, Magnus T Jensen, Peter G Jørgensen, Jørgen K Kanters
BACKGROUND: The association between type 2 diabetes and electrocardiographic (ECG) markers are incompletely explored and the dependence on diabetes duration is largely unknown. We aimed to investigate the electrocardiographic (ECG) changes associated with type 2 diabetes over time. METHODS: In this cross-sectional study, we matched people with type 2 diabetes 1:1 on sex, age, and body mass index with people without diabetes from the general population. We regressed ECG markers with the presence of diabetes and the duration of clinical diabetes, respectively, adjusted for sex, age, body mass index, smoking, heart rate, diabetes medication, renal function, hypertension, and myocardial infarction...
April 20, 2024: Journal of Electrocardiology
#3
JOURNAL ARTICLE
Sibeal McCourt, David Kanter, Graham K MacDonald
Addressing the 'wicked problem' of nutrient pollution requires coordinated policies spanning across diverse sectors and environmental systems. Using a case study of Canadian legislation, we apply semantic network analysis to identify thematic links across an inventory of 245 nutrient-related policies. Our analysis identifies twelve topics with unique types of connections across multiple facets of Canadian society. 'Hub' policies include broad environmental protection, land use planning, and climate-related legislation with close ties to multiple other topics...
April 5, 2024: Ambio
#4
JOURNAL ARTICLE
Daryl P Fields, Gregory Varga, Ali Alattar, Regan Shanahan, Ashtah Das, David K Hamilton, David O Okonkwo, Adam S Kanter, Raquel M Forsythe, Debra K Weiner
BACKGROUND AND OBJECTIVES: Nearly 30% of older adults presenting with isolated spine fractures will die within 1 year. Attempts to ameliorate this alarming statistic are hindered by our inability to identify relevant risk factors. The primary objective of this study was to develop a prediction model that identifies feasible targets to limit 1-year mortality. METHODS: This retrospective cohort study included 703 older adults (65 years or older) admitted to a level I trauma center with isolated spine fractures, without neural deficit, from January 2013 to January 2018...
March 29, 2024: Neurosurgery
#5
JOURNAL ARTICLE
John K Yue, Young M Lee, Xiaoying Sun, Thomas A van Essen, Mahmoud M Elguindy, Patrick J Belton, Dana Pisică, Ana Mikolic, Hansen Deng, John H Kanter, Michael A McCrea, Yelena G Bodien, Gabriela G Satris, Justin C Wong, Vardhaan S Ambati, Ramesh Grandhi, Ava M Puccio, Pratik Mukherjee, Alex B Valadka, Phiroz E Tarapore, Michael C Huang, Anthony M DiGiorgio, Amy J Markowitz, Esther L Yuh, David O Okonkwo, Ewout W Steyerberg, Hester F Lingsma, David K Menon, Andrew I R Maas, Sonia Jain, Geoffrey T Manley
OBJECTIVE: The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticosteroid Randomization After Significant Head Injury (CRASH) prognostic models for mortality and outcome after traumatic brain injury (TBI) were developed using data from 1984 to 2004. This study examined IMPACT and CRASH model performances in a contemporary cohort of US patients. METHODS: The prospective 18-center Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study (enrollment years 2014-2018) enrolled subjects aged ≥ 17 years who presented to level I trauma centers and received head CT within 24 hours of TBI...
March 15, 2024: Journal of Neurosurgery
#6
JOURNAL ARTICLE
Nitin Agarwal, Vijay Letchuman, Raj Swaroop Lavadi, Vivian P Le, Alexander A Aabedi, Saman Shabani, Andrew K Chan, Paul Park, Juan S Uribe, Jay D Turner, Robert K Eastlack, Richard G Fessler, Kai-Ming Fu, Michael Y Wang, Adam S Kanter, David O Okonkwo, Pierce D Nunley, Neel Anand, Gregory M Mundis, Peter G Passias, Shay Bess, Christopher I Shaffrey, Dean Chou, Praveen V Mummaneni
OBJECTIVE: Depression has been implicated with worse immediate postoperative outcomes in adult spinal deformity (ASD) correction, yet the specific impact of depression on those patients undergoing minimally invasive surgery (MIS) requires further clarity. This study aimed to evaluate the role of depression in the recovery of patients with ASD after undergoing MIS. METHODS: Patients who underwent MIS for ASD with a minimum postoperative follow-up of 1 year were included from a prospectively collected, multicenter registry...
February 16, 2024: Journal of Neurosurgery. Spine
#7
F Daniëls, A Adiyaman, K M Aarnink, F J Oosterwerff, J R A Verbakel, A Ghani, J J J Smit, M A Kanters, P P H M Delnoy, A Elvan
No abstract text is available yet for this article.
February 12, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#8
JOURNAL ARTICLE
Rosalie B T M Sterenborg, Inga Steinbrenner, Yong Li, Melissa N Bujnis, Tatsuhiko Naito, Eirini Marouli, Tessel E Galesloot, Oladapo Babajide, Laura Andreasen, Arne Astrup, Bjørn Olav Åsvold, Stefania Bandinelli, Marian Beekman, John P Beilby, Jette Bork-Jensen, Thibaud Boutin, Jennifer A Brody, Suzanne J Brown, Ben Brumpton, Purdey J Campbell, Anne R Cappola, Graziano Ceresini, Layal Chaker, Daniel I Chasman, Maria Pina Concas, Rodrigo Coutinho de Almeida, Simone M Cross, Francesco Cucca, Ian J Deary, Alisa Devedzic Kjaergaard, Justin B Echouffo Tcheugui, Christina Ellervik, Johan G Eriksson, Luigi Ferrucci, Jan Freudenberg, Christian Fuchsberger, Christian Gieger, Franco Giulianini, Martin Gögele, Sarah E Graham, Niels Grarup, Ivana Gunjača, Torben Hansen, Barbara N Harding, Sarah E Harris, Stig Haunsø, Caroline Hayward, Jennie Hui, Till Ittermann, J Wouter Jukema, Eero Kajantie, Jørgen K Kanters, Line L Kårhus, Lambertus A L M Kiemeney, Margreet Kloppenburg, Brigitte Kühnel, Jari Lahti, Claudia Langenberg, Bruno Lapauw, Graham Leese, Shuo Li, David C M Liewald, Allan Linneberg, Jesus V T Lominchar, Jian'an Luan, Nicholas G Martin, Antonela Matana, Marcel E Meima, Thomas Meitinger, Ingrid Meulenbelt, Braxton D Mitchell, Line T Møllehave, Samia Mora, Silvia Naitza, Matthias Nauck, Romana T Netea-Maier, Raymond Noordam, Casia Nursyifa, Yukinori Okada, Stefano Onano, Areti Papadopoulou, Colin N A Palmer, Cristian Pattaro, Oluf Pedersen, Annette Peters, Maik Pietzner, Ozren Polašek, Peter P Pramstaller, Bruce M Psaty, Ante Punda, Debashree Ray, Paul Redmond, J Brent Richards, Paul M Ridker, Tom C Russ, Kathleen A Ryan, Morten Salling Olesen, Ulla T Schultheiss, Elizabeth Selvin, Moneeza K Siddiqui, Carlo Sidore, P Eline Slagboom, Thorkild I A Sørensen, Enrique Soto-Pedre, Tim D Spector, Beatrice Spedicati, Sundararajan Srinivasan, John M Starr, David J Stott, Toshiko Tanaka, Vesela Torlak, Stella Trompet, Johanna Tuhkanen, André G Uitterlinden, Erik B van den Akker, Tibbert van den Eynde, Melanie M van der Klauw, Diana van Heemst, Charlotte Verroken, W Edward Visser, Dina Vojinovic, Henry Völzke, Melanie Waldenberger, John P Walsh, Nicholas J Wareham, Stefan Weiss, Cristen J Willer, Scott G Wilson, Bruce H R Wolffenbuttel, Hanneke J C M Wouters, Margaret J Wright, Qiong Yang, Tatijana Zemunik, Wei Zhou, Gu Zhu, Sebastian Zöllner, Johannes W A Smit, Robin P Peeters, Anna Köttgen, Alexander Teumer, Marco Medici
To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism (T3/FT4 ratio) as well as dichotomized high and low TSH levels. We revealed 259 independent significant associations for TSH (61% novel), 85 for FT4 (67% novel), and 62 novel signals for the T3 related traits...
January 30, 2024: Nature Communications
#9
EDITORIAL
Jørgen K Kanters, Morten S Nielsen
No abstract text is available yet for this article.
December 2023: JACC. Clinical Electrophysiology
#10
JOURNAL ARTICLE
Priya A Prasad, Jonas L Isaksen, Yumiko Abe-Jones, Jessica K Zègre-Hemsey, Claire E Sommargren, Salah S Al-Zaiti, Mary G Carey, Fabio Badilini, David Mortara, Jørgen K Kanters, Michele M Pelter
BACKGROUND: Continuous electrocardiographic (ECG) monitoring is used to identify ventricular tachycardia (VT), but false alarms occur frequently. OBJECTIVE: The purpose of this study was to assess the rate of 30-day in-hospital mortality associated with VT alerts generated from bedside ECG monitors to those from a new algorithm among intensive care unit (ICU) patients. METHODS: We conducted a retrospective cohort study in consecutive adult ICU patients at an urban academic medical center and compared current bedside monitor VT alerts, VT alerts from a new-unannotated algorithm, and true-annotated VT...
November 2023: Heart rhythm O2
#11
JOURNAL ARTICLE
Andrea M Storås, Ole Emil Andersen, Sam Lockhart, Roman Thielemann, Filip Gnesin, Vajira Thambawita, Steven A Hicks, Jørgen K Kanters, Inga Strümke, Pål Halvorsen, Michael A Riegler
Deep neural networks are complex machine learning models that have shown promising results in analyzing high-dimensional data such as those collected from medical examinations. Such models have the potential to provide fast and accurate medical diagnoses. However, the high complexity makes deep neural networks and their predictions difficult to understand. Providing model explanations can be a way of increasing the understanding of "black box" models and building trust. In this work, we applied transfer learning to develop a deep neural network to predict sex from electrocardiograms...
July 11, 2023: Diagnostics
#12
JOURNAL ARTICLE
Ashima Singh, Marci K Sontag, Mei Zhou, Mahua Dasgupta, Tessa Crume, Morgan McLemore, Najibah Galadanci, Eldrida Randall, Nicole Steiner, Amanda M Brandow, Kathryn Koch, Joshua J Field, Kathryn Hassell, Angela B Snyder, Julie Kanter
BACKGROUND: Sickle cell disease (SCD) was first recognized in 1910 and identified as a genetic condition in 1949. However, there is not a universal clinical registry that can be used currently to estimate its prevalence. The Sickle Cell Data Collection (SCDC) program, funded by the Centers for Disease Control and Prevention, funds state-level grantees to compile data within their states from various sources including administrative claims to identify individuals with SCD. The performance of the SCDC administrative claims case definition has been validated in a pediatric population with SCD, but it has not been tested in adults...
June 28, 2023: JMIR Public Health and Surveillance
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JOURNAL ARTICLE
Matthew P Smeltzer, Sarah L Reeves, William O Cooper, Brandon K Attell, John J Strouse, Clifford M Takemoto, Julie Kanter, Krista Latta, Allison P Plaxco, Robert L Davis, Daniel Hatch, Camila Reyes, Kevin Dombkowski, Angela Snyder, Susan Paulukonis, Ashima Singh, Mariam Kayle
OBJECTIVE: Population-level data on sickle cell disease (SCD) are sparse in the United States. The Centers for Disease Control and Prevention (CDC) is addressing the need for SCD surveillance through state-level Sickle Cell Data Collection Programs (SCDC). The SCDC developed a pilot common informatics infrastructure to standardize processes across states. MATERIALS AND METHODS: We describe the process for establishing and maintaining the proposed common informatics infrastructure for a rare disease, starting with a common data model and identify key data elements for public health SCD reporting...
July 2023: JAMIA Open
#14
JOURNAL ARTICLE
Nils Strodthoff, Temesgen Mehari, Claudia Nagel, Philip J Aston, Ashish Sundar, Claus Graff, Jørgen K Kanters, Wilhelm Haverkamp, Olaf Dössel, Axel Loewe, Markus Bär, Tobias Schaeffter
Machine learning (ML) methods for the analysis of electrocardiography (ECG) data are gaining importance, substantially supported by the release of large public datasets. However, these current datasets miss important derived descriptors such as ECG features that have been devised in the past hundred years and still form the basis of most automatic ECG analysis algorithms and are critical for cardiologists' decision processes. ECG features are available from sophisticated commercial software but are not accessible to the general public...
May 13, 2023: Scientific Data
#15
JOURNAL ARTICLE
Peter G Passias, Peter S Tretiakov, Pierce D Nunley, Michael Y Wang, Paul Park, Adam S Kanter, David O Okonkwo, Robert K Eastlack, Gregory M Mundis, Dean Chou, Nitin Agarwal, Richard G Fessler, Juan S Uribe, Neel Anand, Khoi D Than, Gregory Brusko, Kai-Ming Fu, Jay D Turner, Vivian P Le, Breton G Line, Christopher P Ames, Justin S Smith, Christopher I Shaffrey, Robert A Hart, Douglas Burton, Renaud Lafage, Virginie Lafage, Frank Schwab, Shay Bess, Praveen V Mummaneni
OBJECTIVE: Circumferential minimally invasive surgery (cMIS) may provide incremental benefits compared with open surgery for patients with increasing frailty status by decreasing peri- and postoperative complications. METHODS: Operative patients with adult spinal deformity (ASD) ≥ 18 years old with baseline and 2-year postoperative data were assessed. With propensity score matching, patients who underwent cMIS (cMIS group) were matched with similar patients who underwent open surgery (open group) based on baseline BMI, C7-S1 sagittal vertical axis, pelvic incidence to lumbar lordosis mismatch, and S1 pelvic tilt...
April 21, 2023: Journal of Neurosurgery. Spine
#16
JOURNAL ARTICLE
J Kanter, S M Gordon, S Mani, A Sokalska, J Y Park, S Senapati, D D Huh, M Mainigi
STUDY QUESTION: How does an altered maternal hormonal environment, such as that seen during superovulation with gonadotropins in ART, impact human uterine immune cell distribution and function during the window of implantation? SUMMARY ANSWER: Hormonal stimulation with gonadotropins alters abundance of maternal immune cells including uterine natural killer (uNK) cells and reduces uNK cell ability to promote extravillous trophoblast (EVT) invasion. WHAT IS KNOWN ALREADY: An altered maternal hormonal environment, seen following ART, can lead to increased risk for adverse perinatal outcomes associated with disordered placentation...
June 1, 2023: Human Reproduction
#17
JOURNAL ARTICLE
Phay J Ho, Dipanwita Ray, C Stefan Lehmann, Adam E A Fouda, Robert W Dunford, Elliot P Kanter, Gilles Doumy, Linda Young, Donald A Walko, Xuechen Zheng, Lan Cheng, Stephen H Southworth
Characterization of the inner-shell decay processes in molecules containing heavy elements is key to understanding x-ray damage of molecules and materials and for medical applications with Auger-electron-emitting radionuclides. The 1s hole states of heavy atoms can be produced by absorption of tunable x rays and the resulting vacancy decays characterized by recording emitted photons, electrons, and ions. The 1s hole states in heavy elements have large x-ray fluorescence yields that transfer the hole to intermediate electron shells that then decay by sequential Auger-electron transitions that increase the ion's charge state until the final state is reached...
April 7, 2023: Journal of Chemical Physics
#18
JOURNAL ARTICLE
T Tim Bognàr, J S Jurjen Kingma, E H Erin Smeijsters, K C M Kim van der Elst, C T M Klaartje de Kanter, C A Caroline Lindemans, A C G Toine Egberts, I H Imke Bartelink, A Arief Lalmohamed
Busulfan exposure has previously been linked to clinical outcomes, hence the need for therapeutic drug monitoring (TDM). Study objective was to evaluate the effect of day 1 TDM-guided dosing (regimen d1) versus days 1 + 2 TDM-guided dosing (regimen d1 + 2) on attaining adequate busulfan exposure. In this observational study, we included all children receiving busulfan-based allogeneic hematopoietic cell transplantation. Primary outcome was the percentage of patients achieving busulfan target attainment in both TDM regimens...
March 31, 2023: Bone Marrow Transplantation
#19
JOURNAL ARTICLE
Christian Z Jensen, Birte Nygaard, Jens Faber, Palle L Pedersen, Morten K Larsen, Jørgen K Kanters, Henrik E Poulsen, Mark Kellogg, Christina Ellervik
OBJECTIVES: We evaluated the long-term stability of thyroid peroxidase antibody (anti-TPO). METHODS: In the Danish General Suburban Population Study (GESUS), serum samples were biobanked at -80 °C during 2010-2013. In a paired design with 70 subjects, we compared anti-TPO (30-198 U/mL) measured on fresh serum on Kryptor Classic in 2010-2011 (anti-TPOfresh ) with anti-TPO remeasured on frozen serum (anti-TPOfrozen ) on Kryptor Compact Plus in 2022...
August 28, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
#20
JOURNAL ARTICLE
William J Young, Jeffrey Haessler, Jan-Walter Benjamins, Linda Repetto, Jie Yao, Aaron Isaacs, Andrew R Harper, Julia Ramirez, Sophie Garnier, Stefan van Duijvenboden, Antoine R Baldassari, Maria Pina Concas, ThuyVy Duong, Luisa Foco, Jonas L Isaksen, Hao Mei, Raymond Noordam, Casia Nursyifa, Anne Richmond, Meddly L Santolalla, Colleen M Sitlani, Negin Soroush, Sébastien Thériault, Stella Trompet, Stefanie Aeschbacher, Fariba Ahmadizar, Alvaro Alonso, Jennifer A Brody, Archie Campbell, Adolfo Correa, Dawood Darbar, Antonio De Luca, Jean-François Deleuze, Christina Ellervik, Christian Fuchsberger, Anuj Goel, Christopher Grace, Xiuqing Guo, Torben Hansen, Susan R Heckbert, Rebecca D Jackson, Jan A Kors, Maria Fernanda Lima-Costa, Allan Linneberg, Peter W Macfarlane, Alanna C Morrison, Pau Navarro, David J Porteous, Peter P Pramstaller, Alexander P Reiner, Lorenz Risch, Ulrich Schotten, Xia Shen, Gianfranco Sinagra, Elsayed Z Soliman, Monika Stoll, Eduardo Tarazona-Santos, Andrew Tinker, Katerina Trajanoska, Eric Villard, Helen R Warren, Eric A Whitsel, Kerri L Wiggins, Dan E Arking, Christy L Avery, David Conen, Giorgia Girotto, Niels Grarup, Caroline Hayward, J Wouter Jukema, Dennis O Mook-Kanamori, Morten Salling Olesen, Sandosh Padmanabhan, Bruce M Psaty, Cristian Pattaro, Antonio Luiz P Ribeiro, Jerome I Rotter, Bruno H Stricker, Pim van der Harst, Cornelia M van Duijn, Niek Verweij, James G Wilson, Michele Orini, Philippe Charron, Hugh Watkins, Charles Kooperberg, Henry J Lin, James F Wilson, Jørgen K Kanters, Nona Sotoodehnia, Borbala Mifsud, Pier D Lambiase, Larisa G Tereshchenko, Patricia B Munroe
The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (N = 118,780) and 11 for the frontal QRS-T angle (N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures...
March 14, 2023: Nature Communications
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