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https://www.readbyqxmd.com/read/29748316/common-and-rare-coding-genetic-variation-underlying-the-electrocardiographic-pr-interval
#1
Honghuang Lin, Jessica van Setten, Albert V Smith, Nathan A Bihlmeyer, Helen R Warren, Jennifer A Brody, Farid Radmanesh, Leanne Hall, Niels Grarup, Martina Müller-Nurasyid, Thibaud Boutin, Niek Verweij, Henry J Lin, Ruifang Li-Gao, Marten E van den Berg, Jonathan Marten, Stefan Weiss, Bram P Prins, Jeffrey Haessler, Leo-Pekka Lyytikäinen, Hao Mei, Tamara B Harris, Lenore J Launer, Man Li, Alvaro Alonso, Elsayed Z Soliman, John M Connell, Paul L Huang, Lu-Chen Weng, Heather S Jameson, William Hucker, Alan Hanley, Nathan R Tucker, Yii-Der Ida Chen, Joshua C Bis, Kenneth M Rice, Colleen M Sitlani, Jan A Kors, Zhijun Xie, Chengping Wen, Jared W Magnani, Christopher P Nelson, Jørgen K Kanters, Moritz F Sinner, Konstantin Strauch, Annette Peters, Melanie Waldenberger, Thomas Meitinger, Jette Bork-Jensen, Oluf Pedersen, Allan Linneberg, Igor Rudan, Rudolf A de Boer, Peter van der Meer, Jie Yao, Xiuqing Guo, Kent D Taylor, Nona Sotoodehnia, Jerome I Rotter, Dennis O Mook-Kanamori, Stella Trompet, Fernando Rivadeneira, André Uitterlinden, Mark Eijgelsheim, Sandosh Padmanabhan, Blair H Smith, Henry Völzke, Stephan B Felix, Georg Homuth, Uwe Völker, Massimo Mangino, Timothy D Spector, Michiel L Bots, Marco Perez, Mika Kähönen, Olli T Raitakari, Vilmundur Gudnason, Dan E Arking, Patricia B Munroe, Bruce M Psaty, Cornelia M van Duijn, Emelia J Benjamin, Jonathan Rosand, Nilesh J Samani, Torben Hansen, Stefan Kääb, Ozren Polasek, Pim van der Harst, Susan R Heckbert, J Wouter Jukema, Bruno H Stricker, Caroline Hayward, Marcus Dörr, Yalda Jamshidi, Folkert W Asselbergs, Charles Kooperberg, Terho Lehtimäki, James G Wilson, Patrick T Ellinor, Steven A Lubitz, Aaron Isaacs
BACKGROUND: Electrical conduction from the cardiac sinoatrial node to the ventricles is critical for normal heart function. Genome-wide association studies have identified more than a dozen common genetic loci that are associated with PR interval. However, it is unclear whether rare and low-frequency variants also contribute to PR interval heritability. METHODS: We performed large-scale meta-analyses of the PR interval that included 83 367 participants of European ancestry and 9436 of African ancestry...
May 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29745804/protection-against-severe-hypokalemia-but-impaired-cardiac-repolarization-after-intense-rowing-exercise-in-healthy-humans-receiving-salbutamol
#2
Tania Atanasovska, Robert Smith, Claus Graff, Cao Thach Tran, Jacob Melgaard, Jørgen K Kanters, Aaron C Petersen, Antony Tobin, Keld P Kjeldsen, Michael John McKenna
Intense exercise induces pronounced hyperkalemia, followed by transient hypokalemia in recovery. We investigated whether the β2 -agonist salbutamol attenuated the exercise-hyperkalemia, and exacerbated the post-exercise hypokalemia, and whether hypokalemia was associated with impaired cardiac repolarization (QT hysteresis). Eleven healthy adults participated in a randomized, counterbalanced, double-blind trial receiving either 1000 µg salbutamol (SAL) or placebo (PLAC) by inhalation. Arterial plasma potassium concentration ([K+ ]a ) was measured at rest, during 3 min intense rowing exercise and 60 min recovery...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29656917/the-short-term-impacts-of-the-philadelphia-beverage-tax-on-beverage-consumption
#3
Yichen Zhong, Amy H Auchincloss, Brian K Lee, Genevieve P Kanter
INTRODUCTION: On January 1, 2017, Philadelphia implemented a beverage tax of $0.015/ounce on sugar ("regular") and sugar-substitute ("diet") beverages. The purpose of this study was to evaluate the immediate impact of the tax on residents' consumption of soda, fruit drinks, energy drinks, and bottled water. METHODS: A repeat cross-sectional study design used data from a random-digit-dialing phone survey during a no-tax period (December 6-31, 2016) and a tax period (January 15-February 31, 2017) among 899 respondents in Philadelphia, Pennsylvania, and 878 respondents in three nearby comparison cities...
April 11, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29566261/effects-of-trimethoprim-sulfadiazine-and-detomidine-on-the-function-of-equine-k-v-11-1-channels-in-a-two-electrode-voltage-clamp-tevc-oocyte-model
#4
D S Trachsel, M A Tejada, V Groesfjeld Christensen, P J Pedersen, J K Kanters, R Buhl, K Calloe, D A Klaerke
The long QT syndrome (LQTS) is a channelopathy that can lead to severe arrhythmia and sudden cardiac death. Pharmacologically induced LQTS is caused by interaction between drugs and potassium channels, especially the Kv 11.1 channel. Due to such interactions, numerous drugs have been withdrawn from the market or are administered with precautions in human medicine. However, some compounds, such as trimethoprim-sulfonamide combinations are still widely used in veterinarian medicine. Therefore, we investigate the effect of trimethoprim-sulfadiazine (TMS), trimethoprim, sulfadiazine, and detomidine on equine-specific Kv 11...
March 22, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29548277/common-variants-in-the-herg-kcnh2-voltage-gated-potassium-channel-are-associated-with-altered-fasting-and-glucose-stimulated-plasma-incretin-and-glucagon-responses
#5
Line Engelbrechtsen, Yuvaraj Mahendran, Anna Jonsson, Anette Prior Gjesing, Peter E Weeke, Marit E Jørgensen, Kristine Færch, Daniel R Witte, Jens J Holst, Torben Jørgensen, Niels Grarup, Oluf Pedersen, Henrik Vestergaard, Signe Torekov, Jørgen K Kanters, Torben Hansen
BACKGROUND: Patients with long QT syndrome due to rare loss-of-function mutations in the human ether-á-go-go-related gene (hERG) have prolonged QT interval, risk of arrhythmias, increased secretion of insulin and incretins and impaired glucagon response to hypoglycemia. This is caused by a dysfunctional Kv11.1 voltage-gated potassium channel. Based on these findings in patients with rare variants in hERG, we hypothesized that common variants in hERG may also lead to alterations in glucose homeostasis...
March 16, 2018: BMC Genetics
https://www.readbyqxmd.com/read/29395351/end-stage-renal-disease-and-mortality-outcomes-across-different-glomerulonephropathies-in-a-large-diverse-us-population
#6
John J Sim, Simran K Bhandari, Michael Batech, Aviv Hever, Teresa N Harrison, Yu-Hsiang Shu, Dean A Kujubu, Tracy Y Jonelis, Michael H Kanter, Steven J Jacobsen
OBJECTIVE: To compare renal function decline, incident end-stage renal disease (ESRD), and mortality among patients with 5 common glomerular diseases in a large diverse population. PATIENTS AND METHODS: A retrospective cohort study (between January 1, 2000, and December 31, 2011) of patients with glomerulonephropathy using the electronic health record of an integrated health system was performed. Estimated glomerular filtration rate (eGFR) change, incident ESRD, and mortality were compared among patients with biopsy-proven focal segmental glomerulosclerosis (FSGS), membranous glomerulonephritis (MN), minimal change disease (MCD), immunoglobulin A nephropathy (IgAN), and lupus nephritis (LN)...
February 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29311162/differential-expression-and-remodeling-of-transient-outward-potassium-currents-in-human-left-ventricles
#7
Eric K Johnson, Steven J Springer, Wei Wang, Edward J Dranoff, Yan Zhang, Evelyn M Kanter, Kathryn A Yamada, Jeanne M Nerbonne
BACKGROUND: Myocardial, transient, outward currents, I to , have been shown to play pivotal roles in action potential (AP) repolarization and remodeling in animal models. The properties and contribution of I to to left ventricular (LV) repolarization in the human heart, however, are poorly defined. METHODS AND RESULTS: Whole-cell, voltage-clamp recordings, acquired at physiological (35°C to 37°C) temperatures, from myocytes isolated from the LV of nonfailing human hearts identified 2 distinct transient currents, I to,fast ( I to,f ) and I to,slow ( I to,s ), with significantly ( P <0...
January 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29194939/management-of-drug-interactions-with-direct-acting-antivirals-in-dutch-hiv-hepatitis-c-virus-coinfected-patients-adequate-but-not-perfect
#8
E J Smolders, C Smit, Ctmm de Kanter, Asm Dofferhoff, J E Arends, K Brinkman, B Rijnders, M van der Valk, P Reiss, D M Burger
OBJECTIVES: Direct-acting antivirals (DAAs) for treatment of chronic hepatitis C virus (HCV) infection can cause drug-drug interactions (DDIs) with combination antiretroviral therapy (cART) and non-cART co-medication. We mapped how physicians manage DDIs between DAAs and co-medication and analysed treatment outcomes. METHODS: Data were prospectively collected as part of the ATHENA HIV observational cohort and retrospectively analysed. Dutch patients with HIV/HCV coinfection who initiated treatment with DAAs between January 2015 and May 2016 were included...
March 2018: HIV Medicine
https://www.readbyqxmd.com/read/29191102/impact-of-case-type-length-of-stay-institution-type-and-comorbidities-on-medicare-diagnosis-related-group-reimbursement-for-adult-spinal-deformity-surgery
#9
Pierce D Nunley, Gregory M Mundis, Richard G Fessler, Paul Park, Joseph M Zavatsky, Juan S Uribe, Robert K Eastlack, Dean Chou, Michael Y Wang, Neel Anand, Kelly A Frank, Marcus B Stone, Adam S Kanter, Christopher I Shaffrey, Praveen V Mummaneni
OBJECTIVE The aim of this study was to educate medical professionals about potential financial impacts of improper diagnosis-related group (DRG) coding in adult spinal deformity (ASD) surgery. METHODS Medicare's Inpatient Prospective Payment System PC Pricer database was used to collect 2015 reimbursement data for ASD procedures from 12 hospitals. Case type, hospital type/location, number of operative levels, proper coding, length of stay, and complications/comorbidities (CCs) were analyzed for effects on reimbursement...
December 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29191098/complication-rates-associated-with-open-versus-percutaneous-pedicle-screw-instrumentation-among-patients-undergoing-minimally-invasive-interbody-fusion-for-adult-spinal-deformity
#10
Khoi D Than, Praveen V Mummaneni, Kelly J Bridges, Stacie Tran, Paul Park, Dean Chou, Frank La Marca, Juan S Uribe, Todd D Vogel, Pierce D Nunley, Robert K Eastlack, Neel Anand, David O Okonkwo, Adam S Kanter, Gregory M Mundis
OBJECTIVE High-quality studies that compare outcomes of open and minimally invasively placed pedicle screws for adult spinal deformity are needed. Therefore, the authors compared differences in complications from a circumferential minimally invasive spine (MIS) surgery and those from a hybrid surgery. METHODS A retrospective review of a multicenter database of patients with spinal deformity who were treated with an MIS surgery was performed. Database inclusion criteria included an age of ≥ 18 years and at least 1 of the following: a coronal Cobb angle of > 20°, a sagittal vertical axis of > 5 cm, a pelvic incidence-lumbar lordosis angle of > 10°, and/or a pelvic tilt of > 20°...
December 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29182356/improving-antibiotic-stewardship-a-stepped-wedge-cluster-randomized-trial
#11
Adam L Sharp, Yi R Hu, Ernest Shen, Richard Chen, Ryan P Radecki, Michael H Kanter, Michael K Gould
OBJECTIVES: Antibiotic stewardship is key to optimizing patient outcomes and affordable care. The study objective was to examine the effect of provider education and clinical decision support (CDS) on antibiotic prescribing for acute sinusitis among providers of varying experience. STUDY DESIGN: A stepped-wedge cluster randomized intervention to evaluate antibiotic use for acute sinusitis encounters at 126 Kaiser Permanente Southern California clinics between September 2014 and April 2015...
November 1, 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29128143/influence-of-type-of-sport-on-cardiac-repolarization-assessed-by-electrocardiographic-t-wave-morphology-combination-score
#12
Susanne Glasius Tischer, Claus Graff, Christina Ellervik, Eva Prescott, Jørgen K Kanters, Hanne Kruuse Rasmusen
INTRODUCTION: Interpreting repolarization changes in the electrocardiograms of athletes present a clinical challenge. AIM: Assessment of cardiac repolarization by T-wave morphology using the Morphology Combination Score (MCS), and evaluate how this quantitative description of T-wave morphology was influenced by the sport performed. MATERIALS AND METHODS: Digital electrocardiograms of 469 young elite athletes were analyzed for T-wave asymmetry, flatness and notching, and combined in the MCS...
March 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29097701/two-missense-mutations-in-kcnq1-cause-pituitary-hormone-deficiency-and-maternally-inherited-gingival-fibromatosis
#13
Johanna Tommiska, Johanna Känsäkoski, Lasse Skibsbye, Kirsi Vaaralahti, Xiaonan Liu, Emily J Lodge, Chuyi Tang, Lei Yuan, Rainer Fagerholm, Jørgen K Kanters, Päivi Lahermo, Mari Kaunisto, Riikka Keski-Filppula, Sanna Vuoristo, Kristiina Pulli, Tapani Ebeling, Leena Valanne, Eeva-Marja Sankila, Sirpa Kivirikko, Mitja Lääperi, Filippo Casoni, Paolo Giacobini, Franziska Phan-Hug, Tal Buki, Manuel Tena-Sempere, Nelly Pitteloud, Riitta Veijola, Marita Lipsanen-Nyman, Kari Kaunisto, Patrice Mollard, Cynthia L Andoniadou, Joel A Hirsch, Markku Varjosalo, Thomas Jespersen, Taneli Raivio
Familial growth hormone deficiency provides an opportunity to identify new genetic causes of short stature. Here we combine linkage analysis with whole-genome resequencing in patients with growth hormone deficiency and maternally inherited gingival fibromatosis. We report that patients from three unrelated families harbor either of two missense mutations, c.347G>T p.(Arg116Leu) or c.1106C>T p.(Pro369Leu), in KCNQ1, a gene previously implicated in the long QT interval syndrome. Kcnq1 is expressed in hypothalamic GHRH neurons and pituitary somatotropes...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29081908/utility-and-correlation-of-known-anticoagulation-parameters-in-the-management-of-pediatric-ventricular-assist-devices
#14
Ajay K Bhatia, Mouhammad Yabrodi, Mallory Carroll, Silvia Bunting, Kirk Kanter, Kevin O Maher, Shriprasad R Deshpande
AIM: To assess utility and correlation of known anticoagulation parameters in the management of pediatric ventricular assist device (VAD). METHODS: Retrospective study of pediatric patients supported with a Berlin EXCOR VAD at a single pediatric tertiary care center during a single year. RESULTS: We demonstrated associations between activated thromboplastin time (aPTT) and R-thromboelastography (R-TEG) values (rs = 0.65, P < 0.001) and between anti-Xa assay and R-TEG values (rs = 0...
September 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/29068807/antiarrhythmic-effects-of-combining-dofetilide-and-ranolazine-in-a-model-of-acutely-induced-atrial-fibrillation-in-horses
#15
Helena Carstensen, Line Kjær, Maria Mathilde Haugaard, Mette Flethøj, Eva Zander Hesselkilde, Jørgen K Kanters, Steen Pehrson, Rikke Buhl, Thomas Jespersen
BACKGROUND: Antiarrhythmic compounds against atrial fibrillation (AF) often have reduced efficacy and may display cardiac and/or noncardiac toxicity. Efficacy can be improved by combining 2 compounds with distinct mechanisms, and it may be possible to use lower doses of each compound, thereby reducing the likelihood of adverse side effects. The purpose of this study was to investigate whether the effective doses of dofetilide and ranolazine can be reduced if the drugs are combined. METHODS: Dofetilide, ranolazine, and a combination of these were administered in 4 incremental dosing regimens to horses with acutely pacing-induced AF...
January 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28989851/is-there-a-patient-profile-that-characterizes-a-patient-with-adult-spinal-deformity-as-a-candidate-for-minimally-invasive-surgery
#16
Robert K Eastlack, Gregory M Mundis, Michael Wang, Praveen V Mummaneni, Juan Uribe, David Okonkwo, Behrooz A Akbarnia, Neel Anand, Adam Kanter, Paul Park, Virginie Lafage, Christopher Shaffrey, Richard Fessler, Vedat Deviren
STUDY DESIGN: Retrospective review. OBJECTIVES: The goal of this study was to evaluate the baseline characteristics of patients chosen to undergo traditional open versus minimally invasive surgery (MIS) for adult spinal deformity (ASD). METHODS: A multicenter review of 2 databases including ASD patients treated with surgery. Inclusion criteria were age >45 years, Cobb angle minimum of 20°, and minimum 2-year follow-up. Preoperative radiographic parameters and disability outcome measures were reviewed...
October 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28945896/patients-with-high-pelvic-tilt-achieve-the-same-clinical-success-as-those-with-low-pelvic-tilt-after-minimally-invasive-adult-deformity-surgery
#17
Juan S Uribe, Jacob Januszewski, Michael Wang, Neel Anand, David O Okonkwo, Praveen V Mummaneni, Stacie Nguyen, Joseph Zavatsky, Khoi Than, Pierce Nunley, Paul Park, Adam S Kanter, Frank La Marca, Richard Fessler, Gregory M Mundis, Robert K Eastlack
BACKGROUND: Pelvic tilt (PT) is a compensatory mechanism for adult spinal deformity patients to mitigate sagittal imbalance. The association between preop PT and postop clinical and radiographic outcomes has not been well studied in patients undergoing minimally invasive adult deformity surgery. OBJECTIVE: To evaluate clinical and radiographic outcomes in adult spinal deformity patients with high and low preoperative PT treated surgically using less invasive techniques...
August 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28940299/a-history-of-drug-induced-torsades-de-pointes-is-associated-with-t-wave-morphological-abnormalities
#18
Tanveer A Bhuiyan, Claus Graff, Jørgen K Kanters, Jacob Melgaard, Egon Toft, Stefan Kääb, Johannes J Struijk
The hypothesis of the study is that TdP history can be better identified using T-wave morphology compared to QTcF at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The Fridericia-corrected QT interval (QTcF) and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446±9 ms; -TdP: QTcF = 431±9 ms, p = 0...
September 22, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28939174/ventricular-repolarization-alterations-in-women-with-angina-pectoris-and-suspected-coronary-microvascular-dysfunction
#19
Nynne Dose, Marie Mide Michelsen, Naja Dam Mygind, Adam Pena, Christina Ellervik, Peter R Hansen, Jørgen K Kanters, Eva Prescott, Jens Kastrup, Ida Gustafsson, Henrik Steen Hansen
OBJECTIVES: CMD could be the explanation of angina pectoris with no obstructive CAD and may cause ventricular repolarization changes. We compared T-wave morphology and QTc interval in women with angina pectoris with a control group as well as the associations with CMD. METHODS: Women with angina pectoris and no obstructive coronary artery disease (n=138) and age-matched controls were compared in regard to QTc interval and morphology combination score (MCS) based on T-wave asymmetry, flatness and presence of T-wave notch...
January 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28938967/increasing-propensity-to-pursue-operative-closure-of-atrial-septal-defects-following-changes-in-the-instructions-for-use-of-the-amplatzer-septal-occluder-device-an-observational-study-using-data-from-the-pediatric-health-information-systems-database
#20
MULTICENTER STUDY
Michael L O'Byrne, Russell T Shinohara, Elena K Grant, Joshua P Kanter, Matthew J Gillespie, Yoav Dori, Jonathan J Rome, Andrew C Glatz
Concern for device erosion following transcatheter treatment of atrial septal defects (TC-ASD) led in 2012 to a United States Food and Drug Administration panel review and changes in the instructions for use of the Amplatzer Septal Occluder (ASO) device. No studies have assessed the effect of these changes on real-world practice. To this end a multicenter observational study was performed to evaluate trends in the treatment of ASD. METHODS: A retrospective observational study was performed using data from the Pediatric Health Information Systems database of all patients with isolated ASD undergoing either TC-ASD or operative ASD closure (O-ASD) from January 1, 2007, to September 30, 2015, hypothesizing that the propensity to pursue O-ASD increased beginning in 2013...
October 2017: American Heart Journal
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