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https://www.readbyqxmd.com/read/28226723/improving-assessment-of-congenital-heart-disease-through-rapid-patient-specific-modeling
#1
Kathleen Gilbert, Genevieve Farrar, Brett Cowan, Avan Suinesiaputra, Christopher Occleshaw, Beau Pontre, James Perry, Sanjeet Hegde, Jeffrey Omens, Andrew McCulloch, Alistair Young, Kathleen Gilbert, Genevieve Farrar, Brett Cowan, Avan Suinesiaputra, Christopher Occleshaw, Beau Pontre, James Perry, Sanjeet Hegde, Jeffrey Omens, Andrew McCulloch, Alistair Young, James Perry, Genevieve Farrar, Avan Suinesiaputra, Brett Cowan, Kathleen Gilbert, Jeffrey Omens, Christopher Occleshaw, Sanjeet Hegde, Beau Pontre, Andrew McCulloch, Alistair Young
Congenital heart disease is the most common birth defect, with an incidence of 75 in every 1000 births. As a result of improved interventions, 90% of people with congenital heart disease now survive to adulthood. They must undergo regular imaging to assess their biventricular (left and right ventricular) function. Analysis of the images is problematic due to the large variety of shapes and complex geometry. In this paper we extend a biventricular modeling method to improve the analysis of MR images from congenital heart disease patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226227/protective-and-harmful-immunity-to-rsv-infection
#2
Peter J M Openshaw, Chris Chiu, Fiona J Culley, Cecilia Johansson
Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in infection of the ciliated respiratory epithelium, causing disease of variable severity with little or no direct systemic effects. It infects virtually all children by the age of three years and then repeatedly infects throughout life; this it does despite relatively slight variations in antigenicity, apparently by inducing selective immunological amnesia. Inappropriate or dysregulated responses to RSV can be pathogenic, causing disease-enhancing inflammation that contributes to short- and long-term effects...
February 6, 2017: Annual Review of Immunology
https://www.readbyqxmd.com/read/28226183/development-of-an-acceptable-and-feasible-self-management-group-for-children-young-people-and-families-living-with-type-1-diabetes
#3
R A Cai, R I G Holt, L Casdagli, R M Viner, R Thompson, K Barnard, D Christie
AIMS: This study developed an acceptable and feasible self-management intervention that addresses the self-identified needs of children and young people with Type 1 diabetes and their parents. METHODS: Phase 1 reviewed previous interventions and interviewed the clinical team, young people and families. Phase 2 ran three age-matched focus groups with 11 families of children aged 8-16 years. Feedback was used to modify the workshop. Phase 3 evaluated feasibility of delivery, as well as the effects on metabolic control, quality of life and fear of hypoglycaemia, measured at baseline and 1-3 months post intervention...
February 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28225877/synthetic-cannabinoids-in-the-kidneys
#4
Alper Alp, Hakan Akdam, Banu Yılmaz Avcıoğlu, Sibel Ersan
Acute kidney injury is an important cause of mortality and morbidity today and can occur due to several reasons. As time, geographic regions, and living conditions change, various etiological agents arise with nephrotoxic effects. Awareness of such nephrotoxic effects has been raised with the increasing frequency of addictive substance use, especially among young people in society.
January 1, 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28222759/development-and-assessment-of-a-hand-assist-device-gripit
#5
Byungchul Kim, Hyunki In, Dae-Young Lee, Kyu-Jin Cho
BACKGROUND: Although various hand assist devices have been commercialized for people with paralysis, they are somewhat limited in terms of tool fixation and device attachment method. Hand exoskeleton robots allow users to grasp a wider range of tools but are heavy, complicated, and bulky owing to the presence of numerous actuators and controllers. The GRIPIT hand assist device overcomes the limitations of both conventional devices and exoskeleton robots by providing improved tool fixation and device attachment in a lightweight and compact device...
February 21, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28222533/type-1-diabetes-mellitus-and-cognitive-impairments-a-systematic-review
#6
Wei Li, Edgar Huang, Sujuan Gao
Type 1 diabetes mellitus (T1DM) is a major subtype of diabetes and is usually diagnosed at a young age with insulin deficiency. The life expectancy of T1DM patients has increased substantially in comparison with that three decades ago due to the availability of exogenous insulin, though it is still shorter than that of healthy people. However, the relation remains unclear between T1DM and dementia as an aging-related disease. We conducted a systematic review of existing literature on T1DM and cognition impairments by carrying out searches in electronic databases Medline, EMBASE, and Google Scholar...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222522/intranasal-insulin-transport-is-preserved-in%C3%A2-aged-samp8-mice-and-is-altered-by-albumin-and-insulin-receptor-inhibition
#7
Elizabeth M Rhea, Samantha R Humann, Surabhi Nirkhe, Susan A Farr, John E Morley, William A Banks
Insulin delivered to the level of the cribriform plate (intranasal insulin) is being investigated for its ability to enhance memory in people with Alzheimer's disease (AD). Recent work has shown intranasal insulin can be detected in young CD-1 mice within 5 min and is still present 60 min after injection. The current study determined whether intranasal insulin transport and the subsequent brain distribution of insulin varies in young, healthy mice (CD-1) compared to those with an AD-like phenotype (aged SAMP8) or those pre-disposed to develop such a phenotype (young SAMP8)...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222451/what-family-physicians-can-do-to-combat-bullying
#8
REVIEW
Robert J McClowry, Marshal N Miller, Geoffrey D Mills
Bullying has significant health implications for young people and society at large. These screening tools, tips for responding to bullies, and Web resources can help.
February 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28222115/do-family-and-neighbourhood-matter-in-secondary-school-completion-a-multilevel-study-of-determinants-and-their-interactions-in-a-life-course-perspective
#9
Arnhild Myhr, Monica Lillefjell, Geir Arild Espnes, Thomas Halvorsen
BACKGROUND: Completion of secondary education is important for individuals' future health and health behaviour. The fundamental purpose of this study is to investigate the variation and clustering of school completion in families and neighbourhoods. Secondly, we aim to examine the impact of individuals' family structure and neighbourhood of residence and examine to what extent parental education level moderates these associations. METHODS: Longitudinal register data for 30% of the entire Norwegian population aged 21-27 years in 2010 (N = 107,003) was extracted from Statistic Norway´s event database...
2017: PloS One
https://www.readbyqxmd.com/read/28221091/journal-of-personality-and-social-psychology-attitudes-and-social-cognition
#10
Shinobu Kitayama
In this editorial, the new incoming editor for the Journal of Personality and Social Psychology (JPSP)addresses the upcoming challenges and the issue of replicability. Although people vary (often dramatically) in their views on the nature and extent of this issue, that we have an issue to address is something that the new editor thinks most scholars would agree on. It is her hope that engaging in these efforts will return our community to a place that young talent willingly and safely bets their futures on...
March 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28221050/young-children-s-understanding-of-the-limits-and-benefits-of-group-ownership
#11
Michelle Huh, Ori Friedman
Group ownership is ubiquitous-property is owned by countries, corporations, families, and clubs. However, people cannot understand group ownership by simply relying on their conceptions of ownership by individuals, as group ownership is subject to complexities that do not arise when property is individually owned. We report 6 experiments investigating whether children ages 3 to 6 (N = 540) understand group ownership. In Experiments 1 and 2 children were asked who different objects belong to, and they appropriately judged that certain objects are more likely to belong to a group than to individual people...
February 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28219960/comparison-of-substance-use-subjective-well-being-and-interpersonal-relationships-among-young-people-in-foster-care-and-private-households-a-cross-sectional-analysis-of-the-school-health-research-network-survey-in-wales
#12
Sara Jayne Long, Rhiannon E Evans, Adam Fletcher, Gillian Hewitt, Simon Murphy, Honor Young, Graham F Moore
OBJECTIVE: To investigate the association of living in foster care (FC) with substance use and subjective well-being in a sample of secondary school students (11-16 years) in Wales in 2015/16, and to examine whether these associations are attenuated by the perceived quality of interpersonal relationships. DESIGN: Cross-sectional, population-based health behaviour and lifestyle questionnaire. SETTING AND PARTICIPANTS: Wales, UK; young people who took part in the 2015/16 School Health Research Network (SHRN) questionnaire (n=32 479)...
February 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28219388/willingness-to-use-a-supervised-injection-facility-among-young-adults-who-use-prescription-opioids-non-medically-a-cross-sectional-study
#13
Benjamin A Bouvier, Beth Elston, Scott E Hadland, Traci C Green, Brandon D L Marshall
BACKGROUND: Supervised injection facilities (SIFs) are legally sanctioned environments for people to inject drugs under medical supervision. SIFs currently operate in ten countries, but to date, no SIF has been opened in the USA. In light of increasing overdose mortality in the USA, this study evaluated willingness to use a SIF among youth who report non-medical prescription opioid (NMPO) use. METHODS: Between January 2015 and February 2016, youth with recent NMPO use were recruited to participate in the Rhode Island Young Adult Prescription Drug Study (RAPiDS)...
February 20, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28218433/activation-in-the-angular-gyrus-and-in-the-psts-is-modulated-by-face-primes-during-voice-recognition
#14
Cordula Hölig, Julia Föcker, Anna Best, Brigitte Röder, Christian Büchel
The aim of the present study was to better understand the interaction of face and voice processing when identifying people. In a S1-S2 crossmodal priming fMRI experiment, the target (S2) was a disyllabic voice stimulus, whereas the modality of the prime (S1) was manipulated blockwise and consisted of the silent video of a speaking face in the crossmodal condition or of a voice stimulus in the unimodal condition. Primes and targets were from the same speaker (person-congruent) or from two different speakers (person-incongruent)...
February 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28217829/vitamin-d-and-autism-what-s-new
#15
REVIEW
John Jacob Cannell
An increasing amount of evidence points to the possibility that gestational and early childhood vitamin D deficiency [25(OH)D < 40 ng/ml] cause some cases of autism. Vitamin D is metabolized into a seco-steroid hormone that regulates about 3% of the 26,000 genes in the coding human genome. It is also a neurosteroid that is active in brain development, having effects on cellular proliferation, differentiation, calcium signaling, neurotrophic and neuroprotective actions; it also appears to have an effect on neurotransmission and synaptic plasticity...
February 20, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28217548/polygonum-multiflorum-root-extract-as-a-potential-candidate-for-treatment-of-early-graying-hair
#16
Nguyen Dinh Thang, Pham Ngoc Diep, Pham Thi Huong Lien, Le Thi Lien
Despite Polygonum multiflorum (PM) has been experiencely used as a drug to treat early graying hair phenomenon in Asian countries for a long time, there is limited study examined the real biological effects of PM on hair graying in vitro and in vivo. In this study, we investigated the effects of PM root extract (PM-RE) on melanin synthesis in human melanoma SKMEL-28 cells and embryos/larvae of wild-type strain AB zebrafish. We also preliminary revealed the molecular mechanism of early hair graying phenomenon in both in vitro and in vivo models...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28217218/high-prevalence-of-hepatitis-b-virus-infection-in-the-age-range-of-20-39-years-old-individuals-in-lome
#17
Malewe Kolou, Gnatoulma Katawa, Mounerou Salou, Komlan Selom Gozo-Akakpo, Sika Dossim, Alexander Kwarteng, Mireille Prince-David
BACKGROUND: Hepatitis B is a liver infection caused by the hepatitis B virus (HBV). It affects all women and men irrespective of age. Although sub-Saharan Africa is an area of high prevalence of this disease, data on the prevalence of acute and chronic HBV infections in this region remain to be widely documented. OBJECTIVE: This study aimed to investigate the prevalence of HBV in relation to age in Centre Hospitalier Universitaire Campus (CHU-C), one of the two teaching hospitals of Lome, Togo...
2017: Open Virology Journal
https://www.readbyqxmd.com/read/28215752/sex-after-60-you-ve-got-to-be-joking-senior-sexuality-in-comedy-film
#18
Margaret Gatling, Jane Mills, David Lindsay
Representations of the sexuality of older people have been largely absent in mainstream films until recent times. Cinema as an art form has historically denied or ignored the fact that humans are sexual beings their whole lives. In this paper critical discourse analysis is used to examine four comedy films released between 1993 and 2012 that tackle the subject of 'senior sexuality'. All four films are explicit in representing older people as sexual beings but, unlike films about young people's sexual activity, the details of sexual encounters are left to viewers' imaginations...
January 2017: Journal of Aging Studies
https://www.readbyqxmd.com/read/28214912/-the-active-offering-of-measles-rubella-and-mumps-vaccine-in-new-mothers-the-experience-of-health-facilities-in-one-of-the-local-health-unit-of-rome-lazio-italy
#19
Viviana Santoro, Valentina Pettinicchio, Andreina Lancia, Cristiana Vazzoler, Francesca De Luca, Elisabetta Franco
Rubella is a contagious disease that can be very serious, especially in unvaccinated pregnant women. The best way to be protected is getting vaccinated: MMR vaccine is very effective at protecting people against measles, mumps, and rubella, and preventing the complications caused by these diseases. According to PASSI 2012-2015 (the Italian behavioral risk factor surveillance system) in the territory of ex ASL Roma C only 56% of women between 18 and 49 years were immunized against rubella, thanks to vaccination (34%) or past infection detected by rubeotest (22%); 2% was susceptible and 42% of respondents did not know their immune status against rubella...
November 2016: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28213595/qualitative-study-of-the-breather-trial-short-cycle-antiretroviral-therapy-is-it-acceptable-to-young-people-living-with-hiv
#20
Sarah Bernays, Sara Paparini, Janet Seeley, Stella Namukwaya Kihika, Diana Gibb, Tim Rhodes
OBJECTIVES: A qualitative study of the BREATHER (PENTA 16) randomised clinical trial, which compared virological control of Short Cycle Therapy (SCT) (5 days on: 2 days off) with continuous efavirenz (EFV)-based antiretroviral therapy (CT) in children and young people (aged 8-24) living with HIV with viral load <50 c/mL to examine adaptation, acceptability and experience of SCT to inform intervention development. SETTING: Paediatric HIV clinics in the UK (2), Ireland (1), the USA (1) and Uganda (1)...
February 17, 2017: BMJ Open
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