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https://www.readbyqxmd.com/read/29334150/a-general-method-for-the-chemical-synthesis-of-large-scale-seamless-transition-metal-dichalcogenide-electronics
#1
Li Li, Yichuan Guo, Yuping Sun, Long Yang, Liang Qin, Shouliang Guan, Jinfen Wang, Xiaohui Qiu, Hongbian Li, Yuanyuan Shang, Ying Fang
The capability to directly build atomically thin transition metal dichalcogenide (TMD) devices by chemical synthesis offers important opportunities to achieve large-scale electronics and optoelectronics with seamless interfaces. Here, a general approach for the chemical synthesis of a variety of TMD (e.g., MoS2 , WS2 , and MoSe2 ) device arrays over large areas is reported. During chemical vapor deposition, semiconducting TMD channels and metallic TMD/carbon nanotube (CNT) hybrid electrodes are simultaneously formed on CNT-patterned substrate, and then coalesce into seamless devices...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29334016/case-report-to-demonstrate-the-need-for-selection-criteria-for-optimal-adjustable-velcro-wrap-prescription
#2
Suzie Ehmann, Karen Bock
Compression, in the form of either a compression bandage or a compression stocking, has been touted as the gold standard for treatment of swelling and venous leg ulcers (VLUs). Adjustable Velcro wraps have been marketed as compression alternative. Although there is a growing body of evidence to support use of these products, there has not been a critical evaluation of the functionality of the devices to best matching product to patient presentation and ability to use the device effectively. Unlike compression garments, which are classified by compression category (class I/II or flat knit/circular), there is not an algorithm to direct health professionals to best match a specific adjustable Velcro wrap to an individual patient presentation...
January 1, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29333478/a-general-method-for-intracellular-protein-delivery-through-e-tag-protein-engineering-and-arginine-functionalized-gold-nanoparticles
#3
Rubul Mout, Vincent M Rotello
In this protocol, we describe a method for direct cytosolic protein delivery that avoids endosomal entrapment of the delivered proteins. We achieved this by tagging the desired protein with an oligo glutamic acid tag (E-tag), and subsequently using carrier gold nanoparticles to deliver these E-tagged proteins. When E-tagged proteins and nanoparticles were mixed, they formed nanoassemblies, which got fused to cell membrane upon incubation and directly released the E-tagged protein into cell cytosol. We used this method to deliver a wide variety of proteins with different sizes, charges, and functions in various cell lines (Mout et al...
December 20, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29332792/silver-ions-enhanced-auncs-fluorescence-as-a-turn-off-nanoprobe-for-ultrasensitive-detection-of-iodide
#4
Wenli Hou, Yuan Chen, Qiujun Lu, Meiling Liu, Youyu Zhang, Shouzhuo Yao
Fluorescence nanoprobes are frequently employed to construct sensitive biosensors via turn-on and turn-off strategy. In this paper, a novel strategy for ultrasensitive detection of iodide was firstly constructed based on Ag+ regulated photoluminescence enhancement of gold nanoclusters (AuNCs) as a turn-off nanoplatform. In the presence of Ag+, the fluorescence (FL) intensity of AuNCs can be enhanced obviously. When adding iodide ions (I-) in the Ag+-AuNCs, Ag+ can be pulled down from AuNCs and results in quenching of the fluorescent effectively owing to the combination between Ag+ and I-...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29332089/gene-therapy-for-parkinson-s-disease
#5
Vivek Sudhakar, R Mark Richardson
Gene therapy is a clinical tool that may eventually provide therapeutic benefit to patients suffering from movement disorders through a few potential mechanisms: direct correction of the pathogenic mechanism, neuroprotection, neurorestoration or symptom control. The therapeutic mechanism is therefore dependent on knowledge of disease pathogenesis and the required temporal and spatial specificities of gene expression. An additional critical challenge is achieving the most complete transduction of the target structure while avoiding leakage into neighboring regions or perivascular spaces...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29331449/quantifying-axonal-responses-in-patient-specific-models-of-subthalamic-deep-brain-stimulation
#6
Kabilar Gunalan, Bryan Howell, Cameron C McIntyre
Medical imaging has played a major role in defining the general anatomical targets for deep brain stimulation (DBS) therapies. However, specifics on the underlying brain circuitry that is directly modulated by DBS electric fields remain relatively undefined. Detailed biophysical modeling of DBS provides an approach to quantify the theoretical responses to stimulation at the cellular level, and has established a key role for axonal activation in the therapeutic mechanisms of DBS. Estimates of DBS-induced axonal activation can then be coupled with advances in defining the structural connectome of the human brain to provide insight into the modulated brain circuitry and possible correlations with clinical outcomes...
January 10, 2018: NeuroImage
https://www.readbyqxmd.com/read/29331424/ultra-narrow-surface-lattice-resonances-in-plasmonic-metamaterial-arrays-for-biosensing-applications
#7
Artem Danilov, Gleb Tselikov, Fan Wu, Vasyl G Kravets, Igor Ozerov, Frederic Bedu, Alexander N Grigorenko, Andrei V Kabashin
When excited over a periodic metamaterial lattice of gold nanoparticles (~ 100nm), localized plasmon resonances (LPR) can be coupled by a diffraction wave propagating along the array plane, which leads to a drastic narrowing of plasmon resonance lineshapes (down to a few nm full-width-at-half-maximum) and the generation of singularities of phase of reflected light. These phenomena look very promising for the improvement of performance of plasmonic biosensors, but conditions of implementation of such diffractively coupled plasmonic resonances, also referred to as plasmonic surface lattice resonances (PSLR), are not always compatible with biosensing arrangement implying the placement of the nanoparticles between a glass substrate and a sample medium (air, water)...
December 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29329710/hydride-generation-coupled-with-thioglycolic-acid-coated-gold-nanoparticles-as-simple-and-sensitive-headspace-colorimetric-assay-for-visual-detection-of-sb-iii
#8
Tesfaye Tolessa, Zhi-Qiang Tan, Jing-Fu Liu
Antimony (Sb) is a toxic element which causes different health problems including cardiac problems and lung cancer in humans, and its levels in surface water can be noticeably increased to 100 μg/L typically in the proximity of anthropogenic sources. Thus, besides instrumental techniques, it is of great significance to develop a simple, sensitive and selective analytical method for direct analysis of Sb(III) at trace level without the need of any expensive and/or complicated instrumentations and sample preparation processes...
April 3, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29329680/correlation-of-severity-of-chronic-obstructive-pulmonary-disease-with-potential-biomarkers
#9
Seema Singh, S K Verma, Santosh Kumar, M K Ahmad, Anuradha Nischal, S K Singh, R K Dixit
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a non-specific inflammation, which involves the airways, lung parenchyma and pulmonary vessels. The inflammation causes the activation of inflammatory cells and the release of various inflammatory mediators such as interleukin-1 beta, interleukin-6 and tumor necrosis factor alpha (TNF-a). The present study was designed to assess the serum cytokines [Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α)] levels in chronic obstructive pulmonary disease (COPD) patients and they were correlated with severity of disease by spirometric measurements...
January 9, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29329199/pressure-induced-densification-and-compression-in-a-reprocessed-borosilicate-glass
#10
Kathryn J Ham, Yoshio Kono, Parimal J Patel, Steven M Kilczewski, Yogesh K Vohra
Pressure induced densification and compression of a reprocessed sample of borosilicate glass has been studied by X-ray radiography and energy dispersive X-ray diffraction using a Paris-Edinburgh (PE) press at a synchrotron X-ray source. The reprocessing of a commercial borosilicate glass was carried out by cyclical melting and cooling. Gold foil pressure markers were used to obtain the sample pressure by X-ray diffraction using its known equation of state, while X-ray radiography provided a direct measure of the sample volume at high pressure...
January 12, 2018: Materials
https://www.readbyqxmd.com/read/29327963/antemortem-diagnosis-of-coxiellosis-in-a-blue-and-gold-macaw-ara-ararauna
#11
Alison J Flanders, Justin F Rosenberg, Marjorie Bercier, Mary K Leissinger, Laura J Black, Robson F Giglio, Serena L M Craft, Whitney M Zoll, April L Childress, James F X Wellehan
A 15-year-old female blue and gold macaw ( Ara ararauna) was presented for evaluation after being found laterally recumbent, reluctant to move, and lethargic. Results of a complete blood count showed an increased number of immature heterophils with increased cytoplasmic basophilia and degranulation and the presence of a left shift. Radiographs and a computed tomography scan were performed and revealed a markedly enlarged spleen. An ultrasound-guided fine-needle aspirate of the spleen was submitted for cytologic examination and aerobic bacterial culture...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29327429/in-vivo-migration-of-endogenous-brain-progenitor-cells-guided-by-an-injectable-peptide-amphiphile-biomaterial
#12
Reza Motalleb, Eric J Berns, Piyush Patel, Julie Gold, Samuel I Stupp, H Georg Kuhn
Biomaterials hold great promise in helping the adult brain regenerate and rebuild after trauma. Peptide amphiphiles (PA) are highly versatile biomaterials, gelling and forming macromolecular structures when exposed to physiological levels of electrolytes. We are here reporting on the first ever in vivo use of self-assembling peptide amphiphile carrying a Tenascin-C signal (E2 Ten-C PA) for the re-direction of endogenous neuroblasts in the rodent brain. The PA forms highly aligned nanofibers, displaying the migratory sequence of Tenascin-C glycoprotein as epitope...
January 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29325287/-the-diagnostic-value-and-limits-of-diagnostic-parameters-for-wilson-s-disease
#13
X Yang
Wilson disease (WD) is a rare and treatable genetic disorder. This paper describes the new advances and author's long-term experiences in the diagnosis of WD. The characteristics in clinical and routine tests are: the age of presentation can be quite broad, the WD could not be excluded based on age only; the patients usually have mild digestive symptoms but obvious chronic liver disease signs; liver function tests may reveal normal or a mild elevation in bilirubin, ALT and AST, but quite abnormal in serum albumin and prothrombin time in most patients; Coombs-negative hemolytic anemia, normal or markedly subnormal serum alkaline phosphatase (typically < 40 IU/L) are useful for the diagnosis of fulminant WD...
December 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29324776/effect-of-a-lifestyle-intervention-in-obese-infertile-women-on-cardiometabolic-health-and-quality-of-life-a-randomized-controlled-trial
#14
Lotte van Dammen, Vincent Wekker, Anne M van Oers, Meike A Q Mutsaerts, Rebecca C Painter, Aeilko H Zwinderman, Henk Groen, Cornelieke van de Beek, Anneke C Muller Kobold, Walter K H Kuchenbecker, Ron van Golde, Gerrit J E Oosterhuis, Niels E A Vogel, Ben Willem J Mol, Tessa J Roseboom, Annemieke Hoek
BACKGROUND: The prevalence of obesity, an important cardiometabolic risk factor, is rising in women. Lifestyle improvements are the first step in treatment of obesity, but the success depends on factors like timing and motivation. Women are especially receptive to advice about lifestyle before and during pregnancy. Therefore, we hypothesize that the pre-pregnancy period provides the perfect window of opportunity to improve cardiometabolic health and quality of life of obese infertile women, by means of a lifestyle intervention...
2018: PloS One
https://www.readbyqxmd.com/read/29323433/electrically-driven-microengineered-bioinspired-soft-robots
#15
Su Ryon Shin, Bianca Migliori, Beatrice Miccoli, Yi-Chen Li, Pooria Mostafalu, Jungmok Seo, Serena Mandla, Alessandro Enrico, Silvia Antona, Ram Sabarish, Ting Zheng, Lorenzo Pirrami, Kaizhen Zhang, Yu Shrike Zhang, Kai-Tak Wan, Danilo Demarchi, Mehmet R Dokmeci, Ali Khademhosseini
To create life-like movements, living muscle actuator technologies have borrowed inspiration from biomimetic concepts in developing bioinspired robots. Here, the development of a bioinspired soft robotics system, with integrated self-actuating cardiac muscles on a hierarchically structured scaffold with flexible gold microelectrodes is reported. Inspired by the movement of living organisms, a batoid-fish-shaped substrate is designed and reported, which is composed of two micropatterned hydrogel layers. The first layer is a poly(ethylene glycol) hydrogel substrate, which provides a mechanically stable structure for the robot, followed by a layer of gelatin methacryloyl embedded with carbon nanotubes, which serves as a cell culture substrate, to create the actuation component for the soft body robot...
January 11, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29323386/highly-robust-uniform-and-ultra-sensitive-surface-enhanced-raman-scattering-substrates-for-microrna-detection-fabricated-by-using-silver-nanostructures-grown-in-gold-nanobowls
#16
Taeksu Lee, Jung-Sub Wi, Aram Oh, Hee-Kyung Na, JaeJong Lee, Kwangyeol Lee, Tae Geol Lee, Seungjoo Haam
Highly sensitive and reproducible surface enhanced Raman spectroscopy (SERS) requires not only a nanometer-level structural control, but also superb uniformity across the SERS substrate for practical imaging and sensing applications. However, in the past, increased reproducibility of the SERS signal was incompatible with increased SERS sensitivity. This work presents multiple silver nanocrystals inside periodically arrayed gold nanobowls (SGBs) via an electrochemical reaction at an overpotential of -3.0 V (vs...
January 11, 2018: Nanoscale
https://www.readbyqxmd.com/read/29323364/graphene-template-induced-growth-of-single-crystalline-gold-nanobelts-with-high-structural-tunability
#17
Wenbo Xin, Igor M De Rosa, Peiyi Ye, Joseph Severino, Chao Li, Xunqian Yin, Mark S Goorsky, Larry Carlson, Jenn-Ming Yang
Assembling Au nanocrystals with tunable dimensions and shapes on graphene templates has attracted increasing attention recently. However, directly growing anisotropic Au nanobelts on a graphene support has been rarely reported. Here, a facile, one-pot, and surfactant-free route is demonstrated to synthesize well-defined Au nanobelts with the induction of a multilayer graphene (mlG) template. The obtained Au nanobelts are single-crystalline with a preferable (111) orientation. More importantly, their structural evolution starting from Au clusters is systematically investigated using scanning electron microscopy (SEM) and transmission electron microscopy (TEM)...
January 11, 2018: Nanoscale
https://www.readbyqxmd.com/read/29323118/effects-of-crystallographic-and-geometric-orientation-on-ion-beam-sputtering-of-gold-nanorods
#18
J A Hinks, F Hibberd, K Hattar, A Ilinov, D C Bufford, F Djurabekova, G Greaves, A Kuronen, S E Donnelly, K Nordlund
Nanostructures may be exposed to irradiation during their manufacture, their engineering and whilst in-service. The consequences of such bombardment can be vastly different from those seen in the bulk. In this paper, we combine transmission electron microscopy with in situ ion irradiation with complementary computer modelling techniques to explore the physics governing the effects of 1.7 MeV Au ions on gold nanorods. Phenomena surrounding the sputtering and associated morphological changes caused by the ion irradiation have been explored...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322528/mr-and-ct-data-with-multi-observer-delineations-of-organs-in-the-pelvic-area-part-of-the-gold-atlas-project
#19
Tufve Nyholm, Stina Svensson, Sebastian Andersson, Joakim Jonsson, Maja Sohlin, Christian Gustafsson, Elisabeth Kjellén, Karin Söderström, Per Albertsson, Lennart Blomqvist, Björn Zackrisson, Lars E Olsson, Adalsteinn Gunnlaugsson
PURPOSE: We describe a public dataset with MR and CT images of patients performed in the same position with both multi observer and expert consensus delineations of relevant organs in the male pelvic region. The purpose is to provide means for training and validation of segmentation algorithms and methods to convert MR to CT like data, i.e., so called synthetic CT (sCT). ACQUISITION AND VALIDATION METHODS: T1 and T2 weighted MR images as well as CT data was collected for 19 patients at three different departments...
January 11, 2018: Medical Physics
https://www.readbyqxmd.com/read/29319082/%C3%AF-holes-and-%C3%AF-lumps-direct-the-lewis-basic-and-acidic-interactions-of-noble-metal-nanoparticles-introducing-regium-bonds
#20
Joakim Halldin Stenlid, Adam Johannes Johansson, Tore Brinck
Using local DFT-based probes for electrostatic as well as charge transfer/polarization interactions, we are able to characterize Lewis basic and acidic sites on copper, silver and gold nanoparticles. The predictions obtained using the DFT-probes are compared to the interaction energies of the electron donating (CO, H2O, NH3 and H2S) and the electron accepting (BH3, BF3, HCl [H-down] and Na+) compounds. The probes include the local electron attachment energy [E(r)], the average local ionization energy [Ī(r)], and the electrostatic potential [V(r)] and are evaluated on isodensity surfaces located at distances corresponding to typical interaction distances...
January 10, 2018: Physical Chemistry Chemical Physics: PCCP
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