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https://www.readbyqxmd.com/read/28324860/direct-detection-of-two-different-tumor-derived-extracellular-vesicles-by-sam-aunis-lspr-biosensor
#1
Abhimanyu Thakur, Guangyu Qiu, Siu-Pang Ng, Jintao Guan, Jianbo Yue, Youngjin Lee, Chi-Man Lawrence Wu
Extracellular vesicles (EVs) are abundant in various biological fluids including blood, saliva, urine, as well as extracellular milieu. Accumulating evidence has indicated that EVs, which contain functional proteins and small RNAs, facilitate intercellular communication between neighbouring cells, and are critical to maintain various physiological processes. In contrast, EV-derived toxic signals can spread out over the tissues adjacent to the injured area in certain diseases, including brain tumors and neurodegenerative disorders...
March 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28323413/designing-morphology-in-epitaxial-silicon-nanowires-the-role-of-gold-surface-chemistry-and-phosphorus-doping
#2
Seokhyoung Kim, David J Hill, Christopher W Pinion, Joseph D Christesen, James R McBride, James F Cahoon
Vertically-aligned semiconductor nanowires (NWs) have many potential applications for NW-based technologies, ranging from solar cells to intracellular sensors. Aligned NWs can be fabricated by top-down etching of planar wafers or synthesized from the bottom-up using the vapor-liquid-solid (VLS) mechanism to induce epitaxial growth on lattice-matched substrates. The VLS process permits the modulation of dopants along the NW growth axis, which, if combined with dopant-dependent wet-chemical etching, can be used to encode precise morphology...
March 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28318588/comparative-composition-diversity-and-abundance-of-oligosaccharides-in-early-lactation-milk-from-commercial-dairy-and-beef-cows
#3
William M Sischo, Diana M Short, Mareen Geissler, Apichaya Bunyatratchata, Daniela Barile
Prebiotics are nondigestible dietary ingredients, usually oligosaccharides (OS), that provide a health benefit to the host by directly modulating the gut microbiota. Although there is some information describing OS content in dairy-source milk, no information is available to describe the OS content of beef-source milk. Given the different trait emphasis between dairy and beef for milk production and calf survivability, it is plausible that OS composition, diversity, and abundance differ between production types...
March 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28317888/direct-evidence-of-lack-of-colocalisation-of-fluorescently-labelled-gold-labels-used-in-correlative-light-electron-microscopy
#4
Benjamin T Miles, Alexander B Greenwood, David Benito-Alifonso, Hugh Tanner, M Carmen Galan, Paul Verkade, Henkjan Gersen
Fluorescently labelled nanoparticles are routinely used in Correlative Light Electron Microscopy (CLEM) to combine the capabilities of two separate microscope platforms: fluorescent light microscopy (LM) and electron microscopy (EM). The inherent assumption is that the fluorescent label observed under LM colocalises well with the electron dense nanoparticle observed in EM. Herein we show, by combining single molecule fluorescent imaging with optical detection of the scattering from single gold nanoparticles, that for a commercially produced sample of 10 nm gold nanoparticles tagged to Alexa-633 there is in fact no colocalisation between the fluorescent signatures of Alexa-633 and the scattering associated with the gold nanoparticle...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28306682/training-future-anesthesiologists-in-obstetric-care
#5
Mauricio Vasco Ramírez
PURPOSE OF REVIEW: In order for the obstetric anesthesiologist to become a true perioperative / peripartum physician, a change in formative programs and certification process in anesthesia are needed. RECENT FINDINGS: Anesthesia training programs are migrating to competency based medical education (CBME) worldwide. The traditional model of attending lectures, grand rounds, reading textbooks and journal papers should be complemented by virtual modalities such as massive open online courses or online teaching tools...
March 16, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28302973/a-highly-sensitive-colorimetric-method-for-copper-ions-detection-based-on-controlling-the-peroxidase-like-activity-of-au-pt-nanocatalysts
#6
Yuan-Feng Wang, Na Pan, Chi-Fang Peng
In this study, a sensitive colorimetric method for the detection of copper ion (Cu(2+)) was developed based on controlling the peroxidase-like activity of (gold core)@(ultrathin platinum shell) nanocatalysts (Au@Pt-NCs). It was found that D-penicillamine can effectively inhibit the activity of Au@Pt-NCs. After being incubated with Cu(2+), D-penicillamine lost inhibition toward the catalytic ability of Au@Pt-NCs. Based on the above interaction, a colorimetric detection of Cu(2+) was develop by measuring the colorimetric signal variation of the H2O2-3,3',5,5'-tetramethylbenzidine (TMB) reaction...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28301327/high-resolution-respiratory-inductive-plethysmography-in-rats-validation-in-anesthetized-conditions
#7
Timothe Flenet, Julie Fontecave-Jallon, Pierre-Yves Gumery, Charles Eynard, Francois Boucher, Pierre Baconnier, Stephane Tanguy
Respiratory monitoring is often required in experimental physiological and pharmacological studies in rodents. Currently, the mostly used techniques are direct measurement of airflow on intubated animals and whole body plethysmography. Although the reliability of these methods has been broadly demonstrated, they also have several drawbacks such as invasiveness, high cost of use or confinement of the animals. Respiratory Inductive Plethysmography (RIP) is a non-invasive technique already used in medium-sized mammals that has not yet been evaluated in small rodents...
March 16, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28301133/chemical-interface-damping-depends-on-electrons-reaching-the-surface
#8
Benjamin Foerster, Anneli Joplin, Katharina Kaefer, Sirin Celiksoy, Stephan Link, Carsten Sönnichsen
Metallic nanoparticles show extraordinary strong light absorption near their plasmon resonance, orders of magnitude larger compared to nonmetallic nanoparticles. This "antenna" effect has recently been exploited to transfer electrons into empty states of an attached material, for example to create electric currents in photovoltaic devices or to induce chemical reactions. It is generally assumed that plasmons decay into hot electrons, which then transfer to the attached material. Ultrafast electron-electron scattering reduces the lifetime of hot electrons drastically in metals and therefore strongly limits the efficiency of plasmon induced hot electron transfer...
March 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/28300769/aptamers-biomedical-interest-and-applications
#9
EDITORIAL
Cristina Romero-López, Alfredo Berzal-Herranz
Aptamers are short DNA or RNA oligonucleotides specialized in the specific and efficient binding to a target molecule. They are obtained by in vitro selection or evolution processes. It was in 1990 that two independent research groups described the bases of a new in vitro technology for the identification of RNA molecules able to specifically bind to a target [1,2]. Tuerk and Gold established the principals of the in vitro selection process that was named SELEX (Systematic Evolution of Ligands by Exponential enrichment), which is based on iterative cycles of binding, partitioning, and amplification of oligonucleotides from a pool of variant sequences [2]...
March 16, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28300707/psychiatric-and-psychological-impact-of-surgery-while-awake-in-children-for-resection-of-brain-tumors
#10
Elise Riquin, Mickael Dinomais, Jean Malka, Thierry Lehousse, Philippe Duverger, Philippe Menei, Matthieu Delion
Intraoperative direct stimulation during surgery while awake is considered to be the gold standard for identifying eloquent cortical sites. Only a few studies have referenced the psychological impact of this event in the pediatric population. OBJECTIVE: The aim of this clinical study is to present the psychological aspects of surgery while awake in children. We question the psychiatric contraindications and age limits, and the impact on children, with particular attention to the psychological conditioning and experience of these patients...
March 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28299717/physical-activity-and-maximal-oxygen-uptake-in-adults-with-prader-willi-syndrome
#11
Itai Gross, Harry J Hirsch, Naama Constantini, Shachar Nice, Yehuda Pollak, Larry Genstil, Talia Eldar-Geva, Varda Gross Tsur
BACKGROUND: Prader-Willi Syndrome (PWS) is the most common genetic syndrome causing life-threatening obesity. Strict adherence to a low-calorie diet and regular physical activity are needed to prevent weight gain. Direct measurement of maximal oxygen uptake (VO2 max), the "gold standard" for assessing aerobic exercise capacity, has not been previously described in PWS. OBJECTIVES: Assess aerobic capacity by direct measurement of VO2 max in adults with PWS, and in age and BMI-matched controls (OC), and compare the results with values obtained by indirect prediction methods...
March 16, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28299680/application-of-a-nanostructured-enzymatic-biosensor-based-on-fullerene-and-gold-nanoparticles-to-polyphenol-detection
#12
Cristina Tortolini, Gabriella Sanzò, Riccarda Antiochia, Franco Mazzei, Gabriele Favero
Electrochemical biosensors provide an attractive means of analyzing the content of a biological sample due to the direct conversion of a biological event to an electronic signal. The signal transduction and the general performance of electrochemical biosensors are often determined by the surface architectures that connect the sensing element to the biological sample at the nanometer scale. The most common surface modification techniques, the various electrochemical transduction mechanisms, and the choice of the recognition receptor molecules all influence the ultimate sensitivity of the sensor...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28295988/measurement-of-plasma-cell-free-dna-concentrations-in-dogs-with-sepsis-trauma-and-neoplasia
#13
Jo-Annie Letendre, Robert Goggs
OBJECTIVES: To determine if cell-free DNA (cfDNA) was identifiable in canine plasma, to evaluate 3 techniques for the measurement of plasma cfDNA concentrations in dogs presented to an emergency service, and to compare the plasma cfDNA concentrations of healthy dogs to those with sepsis, trauma, and neoplasia. DESIGN: Retrospective study of banked canine plasma samples collected between May 2014 and December 2014. SETTING: Dogs presented to the emergency service of a university veterinary teaching hospital...
March 10, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28295508/pharmacological-treatment-for-copd-gold-2017-changes-direction
#14
EDITORIAL
Dave Singh
No abstract text is available yet for this article.
March 9, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28294582/pioneering-medical-advances-through-nanofluidic-implantable-technologies
#15
REVIEW
R Lyle Hood, Gold Darr Hood, Mauro Ferrari, Alessandro Grattoni
Nanofluidic implantables represent a recent advance in a broad effort for developing personalized, point-of-care medical technologies. Such systems have unprecedented potential when matched with the newest developments in robotics, microprocessing, and tissue engineering. In this review, we present their emergence in medicine within the fields of diagnostics, biosensing, therapeutics, and theranostics. Discussion includes current limitations and future directions for these systems, as commensurate advances in power density and electronic processing are continually redefining the possible...
March 10, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28294235/steam-reforming-of-methanol-over-oxide-decorated-nanoporous-gold-catalysts-a-combined-in-situ-ftir-and-flow-reactor-study
#16
J Shi, C Mahr, M M Murshed, T M Gesing, A Rosenauer, M Bäumer, A Wittstock
Methanol as a green and renewable resource can be used to generate hydrogen by reforming, i.e., its catalytic oxidation with water. In combination with a fuel cell this hydrogen can be converted into electrical energy, a favorable concept, in particular for mobile applications. Its realization requires the development of novel types of structured catalysts, applicable in small scale reactor designs. Here, three different types of such catalysts were investigated for the steam reforming of methanol (SRM). Oxides such as TiO2 and CeO2 and mixtures thereof (Ce1Ti2Ox) were deposited inside a bulk nanoporous gold (npAu) material using wet chemical impregnation procedures...
March 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28294202/navigation-in-implantology
#17
Insa Herklotz, Florian Beuer, Andreas Kunz, Detlef Hildebrand
The primary objective of implant insertion is optimal prosthetic implant positioning while simultaneously protecting sensitive anatomical structures. In this context, navigated implants show significantly better results than freehand-inserted implants. Computer-assisted navigation, in combination with three-dimensional (3D) imaging by cone beam computed tomography (CBCT), is an ideal way to achieve higher predictability for successful implant therapy. Basically, one can distinguish between static navigation using templates, and direct dynamic navigation using optical transmission systems...
2017: International Journal of Computerized Dentistry
https://www.readbyqxmd.com/read/28293834/synthesis-and-evaluation-of-novel-hcv-replication-inhibitors
#18
David C McGowan, Mourad D Khamlichi, Alex De Groot, Frederik Pauwels, Frédéric Delouvroy, Kristof Van Emelen, Kenneth Simmen, Pierre Raboisson
Direct acting antiviral agents to cure hepatitis C virus (HCV) infection has emerged as the gold standard therapy. Along with protease inhibitors, nucleoside polymerase inhibitors and non-nucleoside polymerase inhibitors, the inhibition of NS5a has proved to be an effective way to treat HCV patients. Here we report on novel HCV NS5a inhibitors which were synthesized and evaluated in the HCV replicon assay. A series of inhibitors were formed by a cycloaddition reaction in parallel to establish new leads and explore the effects of unsymmetrical cap substitution...
March 14, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28293725/a-nano-au-c-mwcnt-based-label-free-amperometric-immunosensor-for-the-detection-of-capsicum-chlorosis-virus-in-bell-pepper
#19
Anshul Sharma, Ankur Kaushal, Saurabh Kulshrestha
Accurate and on time diagnosis of plant viruses is an essential prerequisite for efficient control in field conditions. A number of diagnostic methods have been reported with the required level of sensitivity. Here, we propose a label free immunosensor for efficient and sensitive detection of capsicum chlorosis virus (CaCV) in bell pepper. Antigen was immobilized over the surface of gold nanoparticle/multi-walled carbon nanotube (Nano-Au/C-MWCNT) screen printed electrodes using 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC)/N-hydroxysuccinimide (NHS) cross linking chemistry followed by interaction with groundnut bud necrosis virus (GBNV)/CaCV specific polyclonal antibody...
March 14, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28292018/vitis-vinifera-peel-and-seed-gold-nanoparticles-exhibit-chemopreventive-potential-antioxidant-activity-and-induce-apoptosis-through-mutant-p53-bcl-2-and-pan-cytokeratin-down-regulation-in-experimental-animals
#20
J Grace Nirmala, R T Narendhirakannan
Several studies suggest surface modifications of gold nanoparticles (AuNPs) by capping agents or surface coatings could play an important role in biological systems, and site directed delivery. The present study was carried out to assess the antioxidant and apoptotic activities of the Vitis vinifera peel and seed gold nanoparticles in experimentally induced cancer in Swiss albino mice. 12-dimethylbenz [a] anthracene (DMBA) (single application) and 12-O-tetradecanoylphorbol 13-acetate (TPA) (thrice a week) were applied on the dorsal area of the skin to induce skin papillomagenesis in Swiss albino mice for 16 weeks...
March 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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