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https://www.readbyqxmd.com/read/28550286/ultrasensitive-multiplexed-immunoassay-of-autophagic-biomarkers-based-on-au-rgo-and-au-nanocages-amplifying-electrochemcial-signal
#1
Guannan Wang, Yankun Li, Jinlei Liu, Yajing Yuan, Zhaoliang Shen, Xifan Mei
A novel sandwich-assay electrochemical immunosensor for simultaneous determination of autophagic biomarkers was introduced for the first time, the gold-reduced grapheme oxide nanocomposite (Au/r-GO) set as a good conductive platform with super high specific area, and provided more binding sites for the both antibodies of Beclin-1 and LC3B-II. While Au nanocages (AuNCs) served as good conductive platform to encapsulate a large amount of redox probe and secondary antibodies for signal amplification, due to the abundant reactive oxygen functional groups on its surface...
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28549421/comparison-of-vividtrac%C3%A2-airtraq%C3%A2-king-vision%C3%A2-macintosh-laryngoscope-and-a-custom-made-videolaryngoscope-for-difficult-and-normal-airways-in-mannequins-by-novices
#2
Szilárd Rendeki, Dóra Keresztes, Gábor Woth, Ákos Mérei, Martin Rozanovic, Mátyás Rendeki, József Farkas, Diána Mühl, Bálint Nagy
BACKGROUND: Direct laryngoscopy remains the gold standard for endotracheal intubation and is preferred by experienced operators. However, an increasing number of reports currently support videolaryngoscopy, particularly for novice users. The widespread use of videolaryngoscopy may be limited due to financial limitations, especially in low-income countries. Therefore, affordable single-use scopes are now becoming increasingly popular. We sought to compare these new scopes with direct laryngoscopes and the previously tested videolaryngoscopes in mannequins by novices...
May 26, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28548103/an-aavp-based-solid-phase-transducing-matrix-for-transgene-delivery-potential-for-translational-applications
#3
T L Smith, G R Souza, R L Sidman, W Arap, R Pasqualini
A hybrid vector of adeno-associated virus and phage (termed AAVP) has been introduced as a platform for systemic ligand-directed delivery of transgenes to tumors over the past decade. A series of studies have evaluated the AAVP platform for potential theranostic or purely therapeutic applications in several tumor models. Sufficient ligand-directed tumor targeting consistently resulted in specific molecular-genetic imaging and/or anti-tumor responses to 'suicide' transgene delivery. However, efforts to optimize transduction efficiency are still ongoing...
May 26, 2017: Cancer Gene Therapy
https://www.readbyqxmd.com/read/28546538/droplet-digital-pcr-versus-qpcr-for-gene-expression-analysis-with-low-abundant-targets-from-variable-nonsense-to-publication-quality-data
#4
Sean C Taylor, Genevieve Laperriere, Hugo Germain
Quantitative PCR (qPCR) has become the gold standard technique to measure cDNA and gDNA levels but the resulting data can be highly variable, artifactual and non-reproducible without appropriate verification and validation of both samples and primers. The root cause of poor quality data is typically associated with inadequate dilution of residual protein and chemical contaminants that variably inhibit Taq polymerase and primer annealing. The most susceptible, frustrating and often most interesting samples are those containing low abundant targets with small expression differences of 2-fold or lower...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28545366/role-of-positron-emission-tomography-for-central-nervous-system-involvement-in-systemic-autoimmune-diseases-status-and-perspectives
#5
Daniele Mauro, Gaetano Barbagallo, Salvatore D'Angelo, Sannino Pasqualina, Saverio Naty, Caterina Bruno, Ignazio Olivieri, Rosa Daniela Grembiale, Francesco Ursini
In the last years, an increasing interest in molecular imaging has been raised by the extending potential of positron emission tomography (PET). The role of PET imaging, originally confined to the oncology setting, is continuously extending thanks to the development of novel radiopharmaceutical and to the implementation of hybrid imaging techniques, where PET scans are combined with computed tomography (CT) or magnetic resonance imaging(MRI) in order to improve spatial resolution. Early preclinical studies suggested that 18F-FDG PET can detect neuroinflammation; new developing radiopharmaceuticals targeting more specifically inflammation-related molecules are moving in this direction...
May 23, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28545060/signet-a-signaling-network-data-simulator-to-enable-signaling-network-inference
#6
Elizabeth A Coker, Costas Mitsopoulos, Paul Workman, Bissan Al-Lazikani
Network models are widely used to describe complex signaling systems. Cellular wiring varies in different cellular contexts and numerous inference techniques have been developed to infer the structure of a network from experimental data of the network's behavior. To objectively identify which inference strategy is best suited to a specific network, a gold standard network and dataset are required. However, suitable datasets for benchmarking are difficult to find. Numerous tools exist that can simulate data for transcriptional networks, but these are of limited use for the study of signaling networks...
2017: PloS One
https://www.readbyqxmd.com/read/28545034/characterization-of-sudan-ebolavirus-infection-in-ferrets
#7
Andrea Kroeker, Shihua He, Marc-Antoine de La Vega, Gary Wong, Carissa Embury-Hyatt, Xiangguo Qiu
Sudan virus (SUDV) outbreaks in Africa are highly lethal; however, the development and testing of novel antivirals and vaccines for this virus has been limited by a lack of suitable animal models. Non-human primates (NHP) remain the gold standard for modeling filovirus disease, but they are not conducive to screening large numbers of experimental compounds and should only be used to test the most promising candidates. Therefore, other smaller animal models are a valuable asset. We have recently developed a guinea-pig adapted SUDV virus that is lethal in guinea pigs...
May 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28544622/an-investigation-into-the-two-stage-meta-analytic-copula-modelling-approach-for-evaluating-time-to-event-surrogate-endpoints-which-comprise-of-one-or-more-events-of-interest
#8
Natalie Dimier, Susan Todd
Clinical trials of experimental treatments must be designed with primary endpoints that directly measure clinical benefit for patients. In many disease areas, the recognised gold standard primary endpoint can take many years to mature, leading to challenges in the conduct and quality of clinical studies. There is increasing interest in using shorter-term surrogate endpoints as substitutes for costly long-term clinical trial endpoints; such surrogates need to be selected according to biological plausibility, as well as the ability to reliably predict the unobserved treatment effect on the long-term endpoint...
May 19, 2017: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/28544447/modulation-of-wetting-gradients-by-tuning-the-interplay-between-surface-structuration-and-anisotropic-molecular-layers-with-bipolar-electrochemistry
#9
Laurent Bouffier, Stéphane Reculusa, Valérie Ravaine, Alexander Kuhn
A new simple and versatile method for the preparation of surface wetting gradients is proposed. It is based on the combination of electrode surface structuration introduced by a sacrificial template approach and the formation of a tuneable molecular gradient by bipolar electrochemistry. The gradient involves the formation of a self-assembled monolayer on gold surface by selecting an appropriate thiol molecule and the subsequent reductive desorption by means of bipolar electrochemistry. Under these conditions, the completion of the reductive desorption process evolves along the bipolar surface with a maximum strength localized at the cathodic edge and a decreasing driving force toward the middle of the surface...
May 22, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28544420/gold-i-hydrides-as-proton-acceptors-in-dihydrogen-bond-formation
#10
Ignacy Cukrowski, Jurgens Hendrik de Lange, Ferdinand Groenewald, Helgard G Raubenheimer
Wavefunction and DFT calculations indicate that anionic dihydride complexes of AuI form strong to moderate directed Au-H···H bonds with one or two HF, H₂O and NH₃ prototype proton donor molecules. The largely electrostatic interaction is influenced by relativistic effects which, however, do not increase the binding energy. Very weak Au···H associations - exhibiting a corresponding bond path - occur between neutral AuH and HF units, although ultimately F becomes the preferred donor atom in the most stable structure...
May 25, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28542103/predictive-accuracy-of-surgimaptm-surgical-planning-for-sagittal-imbalance-a-cohort-study
#11
Francesco Langella, Jorge Hugo Villafañe, Marco Damilano, Riccardo Cecchinato, Matteo Pejrona, Maryem Ismael, Pedro Berjano
STUDY DESIGN: A cohort study. OBJECTIVE: To evaluate the predictive value of surgical planning using Surgimap™ regarding postoperative sagittal alignment. SUMMARY OF BACKGROUND DATA: Surgical planning in sagittal imbalance is recognized as a key step of treatment to ensure results. METHODS: The study involved 40 non-consecutive patients who underwent surgery for sagittal misalignment. Postoperative alignment measured by sagittal vertical axis (SVA) and pelvic tilt (PT) was considered the gold standard...
May 25, 2017: Spine
https://www.readbyqxmd.com/read/28541913/virtual-spirometry-and-activity-monitoring-using-multichannel-electrical-impedance-plethysmographs-in-ambulatory-settings
#12
Hassan Aqeel Khan, Amit Gore, Jeffrey Ashe, Shantanu Chakrabartty
Continuous monitoring of respiratory patterns and physical activity levels can be useful for remote health management of patients with conditions such as heart disease and chronic obstructive pulmonary disease. In a clinical setting, spirometers serve as the gold standard for monitoring respiratory patterns such as breathing rate and changes in lung volume. However, direct measurements using a spirometer requires placement of a sensor in the patient's airway and is thus infeasible for continuous monitoring in nonclinical, ambulatory settings...
May 23, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28541693/shuttlecock-shaped-molecular-rectifier-asymmetric-electron-transport-coupled-with-controlled-molecular-motion
#13
Taekhee Ryu, Yves Lansac, Yun Hee Jang
A fullerene derivative with five hydroxyphenyl groups attached around a pentagon, (4-HOC6H4)5HC60 (1), has shown an asymmetric current-voltage (I-V) curve in a conducting atomic force microscopy experiment on gold. Such molecular rectification has been ascribed to the asymmetric distribution of frontier molecular orbitals over its shuttlecock-shaped structure. Our non-equilibrium Green's function (NEGF) calculations based on density functional theory (DFT) indeed exhibit an asymmetric I-V curve for 1 standing up between two Au (111) electrodes, but the resulted rectification ratio (RR ~ 3) is insufficient to explain the wide range of RR observed in experiments performed under a high bias voltage...
May 25, 2017: Nano Letters
https://www.readbyqxmd.com/read/28541036/non-invasive-diagnosis-of-high-grade-urothelial-carcinoma-in-urine-by-raman-spectral-imaging
#14
Hesham K Yosef, Sascha D Krauß, Tatjana Lechtonen, Hendrik Jütte, Andrea Tannapfel, Heiko Udo Käfferlein, Thomas Brüning, Florian Roghmann, Joachim Noldus, Axel Mosig, Samir F El-Mashtoly, Klaus Gerwert
The current gold standard for diagnosis of bladder cancer is cystoscopy, which is an invasive and painful for patients. Therefore, the non-invasive urine cytology is usually used in clinics as an adjunct to cystoscopy. However, it suffers from low sensitivity. Here, a novel non-invasive, label-free approach on urine is presented with high sensitivity. CARS imaging of urine sediments was used in the first step for fast preselection of urothelial cells, where, the high-grade urothelial cancer cells are characterized by a large nucleus to cytoplasm ratio...
May 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28539479/%C3%AE-secretase-inhibitors-in-cancer-clinical-trials-are-pharmacologically-and-functionally-distinct
#15
Yong Ran, Fokhrul Hossain, Antonio Pannuti, Christian B Lessard, Gabriela Z Ladd, Joo In Jung, Lisa M Minter, Barbara A Osborne, Lucio Miele, Todd E Golde
γ-Secretase inhibitors (GSIs) are being actively repurposed as cancer therapeutics based on the premise that inhibition of NOTCH1 signaling in select cancers is therapeutic. Using novel assays to probe effects of GSIs against a broader panel of substrates, we demonstrate that clinical GSIs are pharmacologically distinct. GSIs show differential profiles of inhibition of the various NOTCH substrates, with some enhancing cleavage of other NOTCH substrates at concentrations where NOTCH1 cleavage is inhibited. Several GSIs are also potent inhibitors of select signal peptide peptidase (SPP/SPPL) family members...
May 24, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28537324/validation-of-the-photography-method-for-nutritional-intake-assessment-in-hospitalized-elderly-subjects
#16
F Monacelli, M Sartini, V Bassoli, D Becchetti, A L Biagini, A Nencioni, M Cea, R Borghi, F Torre, P Odetti
OBJECTIVE: The aim of the present study was to validate the photographic indirect method as an accurate and specific tool to assess nutritional intake in a cohort of elderly hospitalized patients. DESIGN: this is a prospective observational study. SETTING: hospital (geriatric acute ward and transitional care of IRCCSS AUO San Martino Hospital, Genoa, Italy). PARTICIPANTS: 255 consecutive elderly hospitalized patients...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28537276/magnetic-field-induced-multiple-topological-phases-in-pyrochlore-iridates-with-mott-criticality
#17
Kentaro Ueda, Taekoo Oh, Bohm-Jung Yang, Ryoma Kaneko, Jun Fujioka, Naoto Nagaosa, Yoshinori Tokura
The interplay between electron correlation and spin-orbit coupling in solids has been proven to be an abundant gold mine for emergent topological phases. Here we report the results of systematic magnetotransport study on bandwidth-controlled pyrochlore iridates R2Ir2O7 near quantum metal-insulator transition (MIT). The application of a magnetic field along [001] crystallographic direction (H//[001]) significantly decreases resistivity while producing a unique Hall response, which indicates the emergence of the novel semi-metallic state in the course of the magnetic transformation from all-in all-out (AIAO, 4/0) to 2-in 2-out (2/2) spin configuration...
May 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28535303/a-novel-goldnano-carb-test-for-rapid-phenotypic-detection-of-carbapenemases-particularly-oxa-type-in-enterobacteriaceae-pseudomonas-aeruginosa-and-acinetobacter-spp
#18
Arpasiri Srisrattakarn, Aroonlug Lulitanond, Chotechana Wilailuckana, Nicha Charoensri, Jureerut Daduang, Aroonwadee Chanawong
Objectives: To develop a simple gold nanoparticle (AuNP)-based colorimetric test, GoldNano Carb (GoldC), for detecting carbapenemase production in Gram-negative bacteria, compared with updated Carba NP (CNP) and CarbAcineto NP (CAcNP) tests by using PCR methods as gold standard. Methods: Ninety-nine carbapenemase-producing Enterobacteriaceae (CPE), Pseudomonas spp. and Acinetobacter spp. isolates and 89 non-CPE isolates were tested by the GoldC and CNP. Additionally, the CAcNP was performed in the Acinetobacter spp...
May 23, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28535039/deposition-of-gold-nanotriangles-in-large-scale-close-packed-monolayers-for-x-ray-based-temperature-calibration-and-sers-monitoring-of-plasmon-driven-catalytic-reactions
#19
Ferenc Liebig, Radwan M Sarhan, Mathias Sander, Wouter A Koopman, Roman Schuetz, Matias Bargheer, Joachim Koetz
Anisotropic plasmonic particles such as gold nanotriangles have extraordinary structural, optical and physico-chemical properties. For many applications in different fields it is essential to prepare them in a chemically and physically stable, structurally well-defined manner, e.g., as large and uniform coverage on a substrate. We present a direct method for the large scale close-packed monolayer formation of edge-to-edge ordered, ultrathin crystalline gold nanotriangles on Si-wafers or quartz glass via the transfer of these asymmetric particles to the air-liquid interface after adding ethanol-toluene mixtures without any subsequent surface functionalization...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28534621/spectral-response-of-plasmonic-gold-nanoparticles-to-capacitive-charging-morphology-effects
#20
Benjamin S Hoener, Hui Zhang, Thomas S Heiderscheit, Silke R Kirchner, Agampodi Swarnapali De Silva Indrasekara, Rashad Baiyasi, Yi-Yu Cai, Peter Nordlander, Stephan Link, Christy F Landes, Wei-Shun Chang
We report a study of the shape-dependent spectral response of the gold nanoparticle surface plasmon resonance at various electron densities to provide mechanistic insight into the role of capacitive charging, a topic of some debate. We demonstrate a morphology dependent spectral response for gold nanoparticles due to capacitive charging using single-particle spectroscopy in an inert electrochemical environment. A decrease in plasmon energy and increase in spectral width for gold nanospheres and nanorods was observed as the electron density was tuned through a potential window of -0...
May 23, 2017: Journal of Physical Chemistry Letters
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