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https://www.readbyqxmd.com/read/29089020/transcriptomic-study-of-salmonella-enterica-subspecies-enterica-serovar-typhi-biofilm
#1
Khee Chian Jason Chin, Todd Duane Taylor, Maxime Hebrard, Kogaan Anbalagan, Marjan Ganjali Dashti, Kia Kien Phua
BACKGROUND: Typhoid fever is an acute systemic infection of humans caused by Salmonella enterica subspecies enterica serovar Typhi (S. Typhi). In chronic carriers, the bacteria survive the harsh environment of the gallbladder by producing biofilm. The phenotype of S. Typhi biofilm cells is significantly different from the free-swimming planktonic cells, and studies have shown that they are associated with antibiotic resistance, immune system evasion, and bacterial persistence. However, the mechanism of this transition and the events leading to biofilm formation are unknown...
October 31, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29064048/patient-physician-relationship-in-specific-cultural-settings
#2
Redouane Abouqal, Jason Phua, Yaseen M Arabi
No abstract text is available yet for this article.
October 24, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28957364/age-related-inverse-dose-relation-of-sedatives-and-analgesics-in-the-intensive-care-unit
#3
Amartya Mukhopadhyay, Bee Choo Tai, Deepa Remani, Jason Phua, Matthew Edward Cove, Yanika Kowitlawakul
Sedative and analgesic practices in intensive care units (ICUs) are frequently based on anesthesia regimes but do not take account of the important patient related factors. Pharmacologic properties of sedatives and analgesics change when used as continuous infusions in ICU compared to bolus or short-term infusions during anesthesia. In a prospective observational cohort study, we investigated the association between patient related factors and sedatives/analgesics doses in patients on mechanical ventilation (MV) and their association with cessation of sedation/analgesia...
2017: PloS One
https://www.readbyqxmd.com/read/28622342/national-survey-of-outcomes-and-practices-in-acute-respiratory-distress-syndrome-in-singapore
#4
Shahla Siddiqui, Zudin Puthucheary, Jason Phua, Benjamin Ho, Jonathan Tan, Siau Chuin, Noelle Louise Lim, Chai Rick Soh, Chian Min Loo, Addy Y H Tan, Amartya Mukhopadhyay, Faheem Ahmed Khan, Azman Johan, Aik Hau Tan, Graeme MacLaren, Juvel Taculod, Blesilda Ramos, Tun Aung Han, Matthew E Cove
INTRODUCTION: In the past 20 years, our understanding of acute respiratory distress syndrome (ARDS) management has improved, but the worldwide incidence and current outcomes are unclear. The reported incidence is highly variable, and no studies specifically characterise ARDS epidemiology in Asia. This observation study aims to determine the incidence, mortality and management practices of ARDS in a high income South East Asian country. METHODS: We conducted a prospective, population based observational study in 6 public hospitals...
2017: PloS One
https://www.readbyqxmd.com/read/28372501/hyperlactatemia-predicts-citrate-intolerance-with-regional-citrate-anticoagulation-during-continuous-renal-replacement-therapy
#5
Jia-Neng Tan, Sabrina Wong Peixin Haroon, Amartya Mukhopadhyay, Titus Lau, Tanusya M Murali, Jason Phua, Zong-Yao Tan, Nicholas Lee, Horng-Ruey Chua
PURPOSE: We aim to determine whether hyperlactatemia, which suggests multi-organ dysfunction and impaired organic substrate metabolism, may predict intolerance to regional citrate anticoagulation (RCA) during continuous venovenous hemofiltration (CVVH). METHODS: We performed a single-center, retrospective observational study in critically ill patients with acute kidney injury or end-stage renal disease and evaluated the association of peak serum lactate levels with citrate intolerance (CI) during the initial 72 hours of RCA-CVVH, defined by serum total-to-ionized calcium >2...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28349179/current-challenges-in-the-management-of-sepsis-in-icus-in-resource-poor-settings-and-suggestions-for-the-future
#6
REVIEW
Marcus J Schultz, Martin W Dunser, Arjen M Dondorp, Neill K J Adhikari, Shivakumar Iyer, Arthur Kwizera, Yoel Lubell, Alfred Papali, Luigi Pisani, Beth D Riviello, Derek C Angus, Luciano C Azevedo, Tim Baker, Janet V Diaz, Emir Festic, Rashan Haniffa, Randeep Jawa, Shevin T Jacob, Niranjan Kissoon, Rakesh Lodha, Ignacio Martin-Loeches, Ganbold Lundeg, David Misango, Mervyn Mer, Sanjib Mohanty, Srinivas Murthy, Ndidiamaka Musa, Jane Nakibuuka, Ary Serpa Neto, Mai Nguyen Thi Hoang, Binh Nguyen Thien, Rajyabardhan Pattnaik, Jason Phua, Jacobus Preller, Pedro Povoa, Suchitra Ranjit, Daniel Talmor, Jonarthan Thevanayagam, C Louise Thwaites
BACKGROUND: Sepsis is a major reason for intensive care unit (ICU) admission, also in resource-poor settings. ICUs in low- and middle-income countries (LMICs) face many challenges that could affect patient outcome. AIM: To describe differences between resource-poor and resource-rich settings regarding the epidemiology, pathophysiology, economics and research aspects of sepsis. We restricted this manuscript to the ICU setting even knowing that many sepsis patients in LMICs are treated outside an ICU...
May 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/27832222/stress-and-burnout-among-physicians-prevalence-and-risk-factors-in-a-singaporean-internal-medicine-programme
#7
LETTER
Kay Choong See, Tow Keang Lim, Ee Heok Kua, Jason Phua, Gerald Sw Chua, Khek Yu Ho
No abstract text is available yet for this article.
October 2016: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/27733188/nurse-performed-screening-for-postextubation-dysphagia-a-retrospective-cohort-study-in-critically-ill-medical-patients
#8
Kay Choong See, Si Yu Peng, Jason Phua, Chew Lai Sum, Johncy Concepcion
BACKGROUND: Swallowing difficulties are common, and dysphagia occurs frequently in intensive care unit (ICU) patients after extubation. Yet, no guidelines on postextubation swallowing assessment exist. We aimed to investigate the safety and effectiveness of nurse-performed screening (NPS) for postextubation dysphagia in the medical ICU. METHODS: We conducted a retrospective cohort study of mechanically ventilated patients who were extubated in a 20-bed medical ICU...
October 12, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27649510/the-use-of-polymerase-chain-reaction-amplification-for-the-detection-of-viruses-and-bacteria-in-severe-community-acquired-pneumonia
#9
Wen Ting Siow, Evelyn Siew-Chuan Koay, Chun Kiat Lee, Hong Kai Lee, Venetia Ong, Wang Jee Ngerng, Hui Fang Lim, Adeline Tan, Julian Wei-Tze Tang, Jason Phua
BACKGROUND: Pathogens are often not identified in severe community-acquired pneumonia (CAP), and the few studies using polymerase chain reaction (PCR) techniques for virus detection are from temperate countries. OBJECTIVE: This study assesses if PCR amplification improves virus and bacteria detection, and if viral infection contributes to mortality in severe CAP in a tropical setting, where respiratory pathogens have less well-defined seasonality. METHODS: In this cohort study of patients with severe CAP in an intensive care unit, endotracheal aspirates for intubated patients and nasopharyngeal swabs for non-intubated patients were sent for PCR amplification for respiratory viruses...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27581386/role-of-bmi-airflow-obstruction-st-george-s-respiratory-questionnaire-and-age-index-in-prognostication-of-asian-copd
#10
Hiang Ping Chan, Amartya Mukhopadhyay, Pauline Lee Poh Chong, Sally Chin, Xue Yun Wong, Venetia Ong, Yiong Huak Chan, Tow Keang Lim, Jason Phua
BACKGROUND AND OBJECTIVE: COPD is a complex condition with a heavy burden of disease. Many multidimensional tools have been studied for their prognostic utility but none has been universally adopted as each has its own limitations. We hypothesize that a multidimensional tool examining four domains, health-related quality of life, disease severity, systemic effects of disease and patient factors, would better categorize and prognosticate these patients. METHODS: We first evaluated 300 patients and found four factors that predicted mortality: BMI, airflow obstruction, St George's Respiratory Questionnaire and age (BOSA)...
January 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27567896/severe-community-acquired-pneumonia-timely-management-measures-in-the-first-24-hours
#11
REVIEW
Jason Phua, Nathan C Dean, Qi Guo, Win Sen Kuan, Hui Fang Lim, Tow Keang Lim
Mortality rates for severe community-acquired pneumonia (CAP) range from 17 to 48 % in published studies.In this review, we searched PubMed for relevant papers published between 1981 and June 2016 and relevant files. We explored how early and aggressive management measures, implemented within 24 hours of recognition of severe CAP and carried out both in the emergency department and in the ICU, decrease mortality in severe CAP.These measures begin with the use of severity assessment tools and the application of care bundles via clinical decision support tools...
August 28, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27415975/confirming-nasogastric-tube-placement-is-the-colorimeter-as-sensitive-and-specific-as-x-ray-a-diagnostic-accuracy-study
#12
Siti Zubaidah Mordiffi, Mien Li Goh, Jason Phua, Yiong-Huak Chan
BACKGROUND: The effect of delivering enteral nutrition or medications via a nasogastric tube that is inadvertently located in the tracheobronchial tract can cause respiratory complications. Although radiographic examination is accepted as the gold standard for confirming the position of patients' enteral tubes, it is costly, involves risks of radiation, and is not failsafe. Studies using carbon dioxide sensors to detect inadvertent nasogastric tube placements have been conducted in intensive care settings...
September 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/27347762/structure-organization-and-delivery-of-critical-care-in-asian-icus
#13
Yaseen M Arabi, Jason Phua, Younsuck Koh, Bin Du, Mohammad Omar Faruq, Masaji Nishimura, Wen-Feng Fang, Charles Gomersall, Hussain N Al Rahma, Hani Tamim, Hasan M Al-Dorzi, Fahad M Al-Hameed, Neill K J Adhikari, Musharaf Sadat
OBJECTIVES: Despite being the epicenter of recent pandemics, little is known about critical care in Asia. Our objective was to describe the structure, organization, and delivery in Asian ICUs. DESIGN: A web-based survey with the following domains: hospital organizational characteristics, ICU organizational characteristics, staffing, procedures and therapies available in the ICU and written protocols and policies. SETTING: ICUs from 20 Asian countries from April 2013 to January 2014...
October 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27217739/prognostic-utility-of-the-2011-gold-classification-and-other-multidimensional-tools-in-asian-copd-patients-a-prospective-cohort-study
#14
COMPARATIVE STUDY
Hiang Ping Chan, Amartya Mukhopadhyay, Pauline Lee Poh Chong, Sally Chin, Xue Yun Wong, Venetia Ong, Yiong Huak Chan, Tow Keang Lim, Jason Phua
BACKGROUND: How well the 2011 Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification prognosticates for Asian patients with COPD is unknown. OBJECTIVE: The authors aimed to study the predictive utility of the GOLD 2011 classification for exacerbations and mortality as compared with other multidimensional tools in an Asian population. METHODS: In all, 1,110 COPD patients were prospectively followed between March 2008 and March 2013...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27161082/erratum-to-withholding-and-withdrawal-of-life-sustaining-treatments-in-low-middle-income-versus-high-income-asian-countries-and-regions
#15
Jason Phua, Gavin M Joynt, Masaji Nishimura, Yiyun Deng, Sheila Nainan Myatra, Yiong Huak Chan, Nguyen Gia Binh, Cheng Cheng Tan, Mohammad Omar Faruq, Yaseen M Arabi, Bambang Wahjuprajitno, Shih-Feng Liu, Seyed Mohammad Reza Hashemian, Waqar Kashif, Dusit Staworn, Jose Emmanuel Palo, Younsuck Koh
No abstract text is available yet for this article.
July 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27071388/withholding-and-withdrawal-of-life-sustaining-treatments-in-low-middle-income-versus-high-income-asian-countries-and-regions
#16
COMPARATIVE STUDY
Jason Phua, Gavin M Joynt, Masaji Nishimura, Yiyun Deng, Sheila Nainan Myatra, Yiong Huak Chan, Nguyen Gia Binh, Cheng Cheng Tan, Mohammad Omar Faruq, Yaseen M Arabi, Bambang Wahjuprajitno, Shih-Feng Liu, Seyed Mohammad Reza Hashemian, Waqar Kashif, Dusit Staworn, Jose Emmanuel Palo, Younsuck Koh
PURPOSE: To compare the attitudes of physicians towards withholding and withdrawing life-sustaining treatments in intensive care units (ICUs) in low-middle-income Asian countries and regions with those in high-income ones, and to explore differences in the role of families and surrogates, legal risks, and financial considerations between these countries and regions. METHODS: Questionnaire study conducted in May-December 2012 on 847 physicians from 255 ICUs in 10 low-middle-income countries and regions according to the World Bank's classification, and 618 physicians from 211 ICUs in six high-income countries and regions...
July 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/26976220/resident-research-why-some-do-and-others-don-t
#17
Jason Yongsheng Chan, Kaavya Narasimhalu, Orlanda Goh, Xiaohui Xin, Tien Yin Wong, Julian Thumboo, Ghee Chee Phua
INTRODUCTION: Although research is widely considered to be a relevant and essential skill to resident development, the actual participation rate of residents in research remains low, and the factors associated with participation are unclear. METHODS: We examined the participation rate of junior residents in research, and their attitudes and perceived barriers toward research, via an anonymised survey carried out from October to November 2013. The residents were from an established Accreditation Council for Graduate Medical Education-accredited internal medicine residency training programme in Singapore...
April 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/26274367/shock-in-the-first-24-h-of-intensive-care-unit-stay-observational-study-of-protocol-based-fluid-management-reply
#18
LETTER
Kay Choong See, Amartya Mukhopadhyay, Tow Keang Lim, Jason Phua
No abstract text is available yet for this article.
September 2015: Shock
https://www.readbyqxmd.com/read/25644706/observation-of-handover-process-in-an-intensive-care-unit-icu-barriers-and-quality-improvement-strategy
#19
Yanika Kowitlawakul, Benjamin S H Leong, Adela Lua, Rana Aroos, Jie Jun Wong, Nicola Koh, Nicholette Goh, Kay Choong See, Jason Phua, Amartya Mukhopadhyay
OBJECTIVE: To describe the characteristics and barriers in the handover process in a medical intensive care unit. DESIGN: A cross-sectional descriptive study using a checklist to observe nurses and doctors during handover of patients in and out of the intensive care unit. SETTING: The study was conducted at a 1000-bed tertiary hospital in Singapore. The unit admits all patients under university medicine clusters, except those needing cardiology services...
April 2015: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/25608139/shock-in-the-first-24-h-of-intensive-care-unit-stay-observational-study-of-protocol-based-fluid-management
#20
Kay Choong See, Amartya Mukhopadhyay, Samuel Chuan-Xian Lau, Sandra Ming-Yien Tan, Tow Keang Lim, Jason Phua
Precision in fluid management for shock could lead to better clinical outcomes. We evaluated the association of protocol-based fluid management with intensive care unit (ICU) and hospital mortality. We performed an observational study of mechanically ventilated patients admitted directly from our emergency department to the ICU from August 2011 to December 2013, who had circulatory shock in the first 24 h of ICU stay (systolic blood pressure <90 mmHg at ICU admission or lactate >4 mmol/L). Patients with onset of shock beyond 24 h of ICU stay were excluded...
May 2015: Shock
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