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https://www.readbyqxmd.com/read/27908544/inhibition-of-cartilage-degradation-and-suppression-of-pge2-and-mmps-expression-by-pomegranate-fruit-extract-in-a-model-of-posttraumatic-osteoarthritis
#1
Nahid Akhtar, Nazir M Khan, Omer S Ashruf, Tariq M Haqqi
OBJECTIVE: Osteoarthritis (OA) is characterized by cartilage degradation in the affected joints. Pomegranate fruit extract (PFE) inhibits cartilage degradation in vitro. The aim of this study was to determine whether oral consumption of PFE inhibits disease progression in rabbits with surgically induced OA. METHODS: OA was surgically induced in the tibiofemoral joints of adult New Zealand White rabbits. In one group, animals were fed PFE in water for 8 wk postsurgery...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27870967/osthole-inhibits-the-expressions-of-collagen-i-and-iii-through-smad-signaling-pathway-after-treatment-with-tgf-%C3%AE-1-in-mouse-cardiac-fibroblasts
#2
Jin-Cheng Liu, Feng Wang, Mei-Lin Xie, Zong-Qi Cheng, Qiong Qin, Lin Chen, Rong Chen
BACKGROUND: Osthole, a natural coumarin and bioactive compound isolated from the fruit of Cnidium monnieri (L.) Cusson, was reported to prevent isoprenaline-induced myocardial fibrosis in mice by inhibiting the transforming growth factor-β1 (TGF-β1) expression, but the underlying mechanism is still unclear. The aim of this study is to illuminate whether the mechanism of osthole inhibiting collagen I and III expressions is associated with Smad signaling pathway in mouse cardiac fibroblasts (CFs) treated with TGF-β1...
November 10, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27832180/cordyceps-militaris-treatment-preserves-renal-function-in-type-2-diabetic-nephropathy-mice
#3
Sung-Hsun Yu, Navneet Kumar Dubey, Wei-Shan Li, Ming-Che Liu, Han-Sun Chiang, Sy-Jye Leu, Ying-Hua Shieh, Feng-Chou Tsai, Win-Ping Deng
Diabetic nephropathy is derived from long-term effects of high blood glucose on kidney function in type 2 diabetic patients. Several antidiabetic drugs and herbal medications have failed to prevent episodes of DN. Hence, this study aimed to further investigate the renal injury-reducing effect of antidiabetic CmNo1, a novel combination of powders of fruiting bodies and mycelia of Cordyceps militaris. After being administered with streptozotocin-nicotinamide and high-fat-diet, the diabetic nephropathy mouse model displayed elevated blood glucose and renal dysfunction markers including serum creatinine and kidney-to-body weight ratio...
2016: PloS One
https://www.readbyqxmd.com/read/27776513/the-antifibrotic-and-fibrolytic-properties-of-date-fruit-extract-via-modulation-of-genotoxicity-tissue-inhibitor-of-metalloproteinases-and-nuclear-factor-kappa-b-pathway-in-a-rat-model-of-hepatotoxicity
#4
Hala Attia, Nouf Al-Rasheed, Raeesa Mohamad, Nawal Al-Rasheed, Maha Al-Amin
BACKGROUND: Hepatic fibrosis and its end point; cirrhosis, are the major cause of liver failure and death in patients with chronic liver disease. Therefore, the need for an effective treatment is evident. This study was designed to assess the potential effects of aqueous extract of date fruits, either flesh (DFE) or pits (DPE), on oxidative DNA damage and liver inflammation induced by carbon tetrachloride (CCl4) and whether they are related to inhibition of nuclear factor-κB pathway...
October 24, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27771138/hesperidin-interaction-to-collagen-detected-by-physico-chemical-techniques
#5
Noriko Hiraishi, Takahiro Maruno, Naoya Tochio, Ryohei Sono, Masayuki Otsuki, Tsutomu Takatsuka, Junji Tagami, Yuji Kobayashi
OBJECTIVE: Dentin collagen can be modified by some plant-derived flavonoids to improve properties of dentin organic matrix. Hesperidin (HPN), a hesperetin-7-O-rutinoside flavonoid, has a potential of dentin modification for being based on evidence that a treatment with HPN may resist collagenase degradation and arrest demineralization of human dentin. In this study, biophysical and molecular-level information on the interaction of HPN and collagen was investigated. METHODS: HPN is extracted from citrus fruits...
October 19, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27744523/autophagy-induced-by-purple-pitanga-eugenia-uniflora-l-extract-triggered-a-cooperative-effect-on-inducing-the-hepatic-stellate-cell-death
#6
Cristiane C Denardin, Leo A M Martins, Mariana M Parisi, Moema Queiroz Vieira, Silvia R Terra, Florencia M Barbé-Tuana, Radovan Borojevic, Márcia Vizzotto, Tatiana Emanuelli, Fátima Costa Rodrigues Guma
Activated hepatic stellate cells (HSC) are the major source of collagen I in liver fibrosis. Eugenia uniflora L. is a tree species that is widely distributed in South America. E. uniflora L. fruit-popularly known as pitanga-has been shown to exert beneficial properties. Autophagy contributes to the maintenance of cellular homeostasis and survival under stress situation, but it has also been suggested to be an alternative cell death pathway. Mitochondria play a pivotal role on signaling cell death. Mitophagy of damaged mitochondria is an important cell defense mechanism against organelle-mediated cell death signaling...
October 15, 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/27659955/the-healing-effect-of-pistacia-lentiscus-fruit-oil-on-laser-burn
#7
Sameh Ben Khedir, Sana Bardaa, Naourez Chabchoub, Dorsaf Moalla, Zouheir Sahnoun, Tarek Rebai
CONTEXT: Since antiquity, Pistacia lentiscus L. (Anacardiaceae) fruit oil (PLFO) has been used as a remedy for primary health care such as burn treatment. OBJECTIVE: This study assesses the healing effect of PLFO on CO2 laser fractional burn in a rat model. MATERIALS AND METHODS: The study was carried out on 18 adult male Wistar rats. A second-degree laser burn (wound area = 2.2 cm(2)) was inflicted in the dorsal region by the application of CO2 fractional laser within the following parameters; Energy level: 25 MJ and Depth level: 4...
September 23, 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27579922/morinda-citrifolia-linn-reduces-parasite-load-and-modulates-cytokines-and-extracellular-matrix-proteins-in-c57bl-6-mice-infected-with-leishmania-leishmania-amazonensis
#8
Fernando Almeida-Souza, Flávia de Oliveira Cardoso, Bruno Vinicius da Conceição Souza, Tânia Zaverucha do Valle, Joicy Cortez de Sá, Iara Dos Santos da Silva Oliveira, Celeste da Silva Freitas de Souza, Carla Junqueira Moragas Tellis, Maria do Socorro Dos Santos Chagas, Maria Dutra Behrens, Ana Lúcia Abreu-Silva, Kátia da Silva Calabrese
The absence of an effective vaccine and the debilitating chemotherapy for Leishmaniasis demonstrate the need for developing alternative treatments. Several studies conducted with Morinda citrifolia have shown various biological activities, including antileishmanial activity, however its mechanisms of action are unknown. This study aimed to analyze the in vivo activity of M. citrifolia fruit juice (Noni) against Leishmania (Leishmania) amazonensis in C57BL/6 mice. M. citrifolia fruit juice from the Brazilian Amazon has shown the same constitution of other juices produced around the world and liquid chromatography-mass spectrometry analysis identified five compounds: deacetylasperulosidic acid, asperulosidic acid, rutin, nonioside B and nonioside C...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27551767/protective-effects-of-a-blueberry-extract-in-acute-inflammation-and-collagen-induced-arthritis-in-the-rat
#9
Maria-Eduardo Figueira, Mónica Oliveira, Rosa Direito, João Rocha, Paula Alves, Ana-Teresa Serra, Catarina Duarte, Rosário Bronze, Adelaide Fernandes, Dora Brites, Marisa Freitas, Eduarda Fernandes, Bruno Sepodes
Here we investigated the anti-inflammatory effect of a blueberry extract in the carrageenan-induced paw edema model and collagen-induced arthritis model, both in rats. Along with the chemical characterization of the phenolic content of the fruits and extract, the antioxidant potential of the extract, the cellular antioxidant activity and the effects over neutrophils' oxidative burst, were studied in order to provide a mechanistic insight for the anti-inflammatory effects observed. The extract significantly inhibited paw edema formation in an acute model the rat...
August 20, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27488183/platelet-inhibitory-effects-of-juices-from-pachyrhizus-erosus-l-root-and-psidium-guajava-l-fruit-a-randomized-controlled-trial-in-healthy-volunteers
#10
Thitiporn Thaptimthong, Thitima Kasemsuk, Nathawut Sibmooh, Supeenun Unchern
BACKGROUND: The purpose of this study is to investigate cardiovascular benefits of juices obtained from two commonly consumed fruits in Thailand, Pachyrhizus erosus, L. (yam bean) and Psidium guajava, L. (guava), by examining their acute cardiovascular effects in healthy volunteers. Possible involvements of the dietary nitrate on their effects were investigated as well. METHOD: Thirty healthy volunteers were randomly divided into three groups of 10 subjects per group and each group was allocated to drink 500 ml of freshly prepared yam bean root juice, guava fruit juice, or water...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27371734/boysenberry-ingestion-supports-fibrolytic-macrophages-with-the-capacity-to-ameliorate-chronic-lung-remodeling
#11
Odette M Shaw, Roger D Hurst, Jacquie L Harper
Lung fibrosis negatively impacts on lung function in chronic asthma and is linked to the development of profibrotic macrophage phenotypes. Epidemiological studies have found that lung function benefits from increased consumption of fruit high in polyphenols. We investigated the effect of boysenberry consumption, in both therapeutic and prophylactic treatment strategies in a mouse model of chronic antigen-induced airway inflammation. Boysenberry consumption reduced collagen deposition and ameliorated tissue remodeling alongside an increase in the presence of CD68+CD206+arginase+ alternatively activated macrophages in the lung tissue...
September 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27328727/inhibitory-effects-of-schisandra-chinensis-extract-on-acne-related-inflammation-and-uvb-induced-photoageing
#12
Miaomiao Guo, Yue Lu, Junpeng Yang, Xin Zhao, Yanhua Lu
CONTEXT: Schisandra chinensis (Turcz.) Baill. (Schisandraceae) fruit extract (SFE) has been reported to induce non-specific tissue protection against inflammation in vivo. However, the effects of SFE on Propionibacterium acnes-stimulated acne and UVB-irradiated photoageing have yet to be investigated. OBJECTIVE: To systematically investigate the effects of SFE against P. acnes and photoageing in vitro. MATERIALS AND METHODS: Qualitative and quantitative analyses of SFE were performed by HPLC...
June 22, 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27261610/protective-effect-of-berberis-vulgaris-fruit-extract-against-paraquat-induced-pulmonary-fibrosis-in-rats
#13
Seyed Ali Javad-Mousavi, Ali Asghar Hemmati, Saeed Mehrzadi, Azam Hosseinzadeh, Gholamreza Houshmand, Mohammad Reza Rashidi Nooshabadi, Mehrnaz Mehrabani, Mehdi Goudarzi
BACKGROUND: Pulmonary fibrosis induced by paraquat (PQ) has caused a large number of human fatalities all over the world, especially in Asian region. The main potential mechanism of PQ toxicity has been thought to be mediated by ROS. The present study was designed to evaluate the efficacy of the Berberis vulgaris fruit extract (BVFE) against PQ-induced pulmonary fibrosis in rats. METHODS: Forty male rats were randomly divided into five experimental groups each containing eight rats...
July 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27240831/ellagic-acid-reduces-murine-schistosomiasis-mansoni-immunopathology-via-up-regulation-of-il-10-and-down-modulation-of-pro-inflammatory-cytokines-production
#14
Gamal Allam, Abdelaziz S A Abuelsaad, Mohammed A Alblihed, Adnan A Alsulaimani
CONTEXT: The main immunopathology in schistosomiasis mansoni consists of a granulomatous inflammatory and fibrosing reaction in the liver and intestine against tissue trapped parasite eggs, which is mediated by CD4(+ )T cells. Ellagic acid (EA), a natural phenolic compound found in fruits and nuts, has potent anti-oxidant and anti-inflammatory properties. OBJECTIVE: The aim of the present study was to evaluate the potential effect of EA in the treatment of murine schistosomiasis mansoni and its induced immunopathology...
August 2016: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/27222341/ethanol-extract-of-terminalia-chebula-fruit-protects-against-uvb-induced-skin-damage
#15
Swanya Yakaew, Khwunjit Itsarasook, Jatuporn Ngoenkam, Arum Jessadayannamaetha, Jarupa Viyoch, Malyn Ungsurungsie
CONTEXT: The fruit of Terminalia chebula Retz. (Combretaceae) has been used for several therapeutic purposes in Thai folk medicines. Currently, the ethanol extracts containing antioxidant compounds have shown the ability to promote collagen synthesis. OBJECTIVE: This purpose of this work was to study the effects of the ethanol extract from T. chebula fruit on the inhibition of cutaneous photodamage. MATERIALS AND METHODS: The viability of human skin fibroblasts after incubation with T...
May 24, 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27160937/nobiletin-attenuates-cardiac-dysfunction-oxidative-stress-and-inflammatory-in-streptozotocin-induced-diabetic-cardiomyopathy
#16
Ning Zhang, Zheng Yang, Shi-Zhao Xiang, Ya-Ge Jin, Wen-Ying Wei, Zhou-Yan Bian, Wei Deng, Qi-Zhu Tang
Diabetic cardiomyopathy, characterized by the presence of diastolic and/or systolic myocardial dysfunction, is one of the major causes of heart failure. Nobiletin, which is extracted from the fruit peel of citrus, is reported to possess anti-inflammatory, anti-oxidative, and hypolipidemic properties. The purpose of this study was to investigate whether nobiletin exerts the therapeutic effect on streptozotocin-induced diabetic cardiomyopathy (DCM) in mice. 80 experimental male C57BL mice were randomly assigned into four groups: sham + vehicle (VEH/SH), sham + nobiletin (NOB/SH), DCM + vehicle (VEH/DM), and DCM + nobiletin (NOB/DM)...
June 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27136080/purification-and-partial-characterization-of-a-fibrinolytic-enzyme-from-the-fruiting-body-of-the-medicinal-and-edible-mushroom-pleurotus-ferulae
#17
Jun-Hui Choi, Dae-Won Kim, Seung Kim, Sung-Jun Kim
A fibrinolytic metalloprotease with in vitro fibrinolytic effects was purified from the edible mushroom, Pleurotus ferulae using several chromatography steps including anion- and ion-exchange, gel filtration, and fast protein liquid chromatography (FPLC) columns. The molecular mass of the enzyme was estimated to be 20.0 kDa, as determined using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and fibrin zymography. The protease was active at 50 °C, and pH 4.0, 5.0, and 8.0. The fibrinolytic activity of the enzyme was inhibited by EGTA, and strongly inhibited by two metal ions, Cu and Mg...
May 2, 2016: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/27090262/tendon-collagen-crosslinking-offers-potential-to-improve-suture-pullout-in-rotator-cuff-repair-an-ex-vivo-sheep-study
#18
Roland S Camenzind, Karl Wieser, Gion Fessel, Dominik C Meyer, Jess G Snedeker
BACKGROUND: The suture-tendon interface is often the weakest link in tendon to bone repair of massive rotator cuff tears. Genipin is a low-toxicity collagen crosslinker derived from the gardenia fruit that has been shown to augment collagen tissue strength and mechanically arrest tendon-tear progression. QUESTION/PURPOSE: The purpose of the current study was to evaluate whether genipin crosslinking can sufficiently augment the suture-tendon interface to improve suture pullout strength using simple single-loop sutures and the modified Mason-Allen technique...
August 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27077087/altered-stress-fibers-and-integrin-expression-in-the-malpighian-epithelium-of-drosophila-type-iv-collagen-mutants
#19
András A Kiss, Nikoletta Popovics, Gábor Szabó, Katalin Csiszár, Mátyás Mink
Basement membranes (BMs) are highly specialized extracellular matrices (ECMs) that provide support and polarization cues for epithelial cells. Proper adhesion to the BM is pivotal in epithelial cell function and survival. Type IV collagens are the predominant components of all types of BMs, that form an irregular, polygonal lattice and serve as a scaffold for numerous other BM components and BM-associated cells. Mutations in the ubiquitous human BM components COL4A1 and COL4A2 cause a multisystem disorder involving nephropathy...
June 2016: Data in Brief
https://www.readbyqxmd.com/read/26914455/a-study-of-facial-wrinkles-improvement-effect-of-veratric-acid-from-cauliflower-mushroom-through-photo-protective-mechanisms-against-uvb-irradiation
#20
Kyung-Eun Lee, Ji-Eun Park, Eunsun Jung, Jahyun Ryu, Youn Joon Kim, Jong-Kyung Youm, Seunghyun Kang
Solar ultraviolet (UV) irradiation is a primary cause of premature skin aging that is closely associated with the degradation of collagens caused by up-regulation of matrix metalloproteinases (MMPs) or a decrease in collagen synthesis. The phenolic veratric acid (VA, 3,4-dimethoxybenzoic acid) is one of the major benzoic acid derivatives from fruits, vegetables and medicinal mushrooms. VA has been reported to have anti-inflammatory, anti-oxidant and photo-protective effects. In this study, anti-photoaging effects were investigated through the photo-protective mechanisms of VA against UV irradiation in human dermal fibroblasts and the reconstructed human epidermal model...
April 2016: Archives of Dermatological Research
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