keyword
MENU ▼
Read by QxMD icon Read
search

ciprofloxacin

keyword
https://www.readbyqxmd.com/read/28822559/antibiotic-therapy-for-prevention-of-fistula-in-ano-after-incision-and-drainage-of-simple-perianal-abscess-a-randomized-single-blind-clinical-trial
#1
Leila Ghahramani, Mohammad Reza Minaie, Peyman Arasteh, Seyed Vahid Hosseini, Ahmad Izadpanah, Ali Mohammad Bananzadeh, Mahboobe Ahmadbeigi, Zahra Hooshanginejad
BACKGROUND: Much controversy exists regarding the role of antibiotics in the development of fistula in-ano after incision and drainage. We evaluated the role of postoperative antibiotics in the prevention of fistula in-ano after incision and drainage of perianal abscess. METHODS: In a randomized single blind clinical trial study, 307 patients were randomly selected from those referring for incision and drainage of perianal abscess at Shahid Faghihi Hospital, Shiraz, Iran, during September 2013 to September 2014...
August 16, 2017: Surgery
https://www.readbyqxmd.com/read/28820375/epidemiology-of-neisseria-gonorrhoeae-gyrase-a-genotype-los-angeles-california-usa
#2
Ashima A Bhatti, Lao-Tzu Allan-Blitz, Mariana Castrejon, Romney M Humphries, Peera Hemarajata, Jeffrey D Klausner
We investigated the epidemiology of the mutant gyrase A gene, a reliable predictor of ciprofloxacin resistance, in Neisseria gonorrhoeae infections at UCLA Health in Los Angeles, California, USA, during November 1, 2015-August 31, 2016. Among 110 patients with N. gonorrhoeae infections, 48 (44%) had the mutant gyrase A gene.
September 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28820128/molecular-antimicrobial-resistance-surveillance-for-neisseria-gonorrhoeae-northern-territory-australia
#3
David M Whiley, Ella Trembizki, Cameron Buckley, Kevin Freeman, Robert W Baird, Miles Beaman, Marcus Chen, Basil Donovan, Ratan L Kundu, Christopher K Fairley, Rebecca Guy, Tiffany Hogan, John M Kaldor, Mahdad Karimi, Athena Limnios, David G Regan, Nathan Ryder, Jiunn-Yih Su, James Ward, Monica M Lahra
Neisseria gonorrhoeae antimicrobial resistance (AMR) is a globally recognized health threat; new strategies are needed to enhance AMR surveillance. The Northern Territory of Australia is unique in that 2 different first-line therapies, based primarily on geographic location, are used for gonorrhea treatment. We tested 1,629 N. gonorrhoeae nucleic acid amplification test-positive clinical samples, collected from regions where ceftriaxone plus azithromycin or amoxicillin plus azithromycin are recommended first-line treatments, by using 8 N...
September 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28818544/trends-in-antimicrobial-resistance-in-bloodstream-infection-isolates-at-a-large-urban-hospital-in-malawi-1998-2016-a-surveillance-study
#4
Patrick Musicha, Jennifer E Cornick, Naor Bar-Zeev, Neil French, Clemens Masesa, Brigitte Denis, Neil Kennedy, Jane Mallewa, Melita A Gordon, Chisomo L Msefula, Robert S Heyderman, Dean B Everett, Nicholas A Feasey
BACKGROUND: Bacterial bloodstream infection is a common cause of morbidity and mortality in sub-Saharan Africa, yet few facilities are able to maintain long-term surveillance. The Malawi-Liverpool-Wellcome Trust Clinical Research Programme has done sentinel surveillance of bacteraemia since 1998. We report long-term trends in bloodstream infection and antimicrobial resistance from this surveillance. METHODS: In this surveillance study, we analysed blood cultures that were routinely taken from adult and paediatric patients with fever or suspicion of sepsis admitted to Queen Elizabeth Central Hospital, Blantyre, Malawi from 1998 to 2016...
August 14, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28817787/evaluation-of-the-electron-transfer-flavoprotein-etf-as-an-antibacterial-target-in-burkholderia-cenocepacia
#5
Maria S Stietz, Christina Lopez, Osasumwen Osifo, Marcelo Tolmasky, Silvia T Cardona
There are hundreds of essential genes in multidrug resistant bacterial genomes, but only a few of their products are exploited as antibacterial targets. An example is the electron flavoprotein (ETF) which is required for growth and viability in <i>Burkholderia cenocepacia</i>. Here, we evaluated ETF as an antibiotic target for <i>Burkholderia cepacia</i> complex (Bcc). Depletion of the bacterial ETF during infection of <i>Caenorhabditis elegans</i> significantly extended survival of the nematodes, proving that ETF is essential for survival of <i>B...
August 17, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28816710/establishment-of-primary-cell-culture-from-ascitic-fluid-and-solid-tumor-obtained-from-epithelial-ovarian-carcinoma-patients
#6
Rajarshi Kar, Diwesh Chawla, Bindiya Gupta, Mohit Mehndiratta, Neelam Wadhwa, Rachna Agarwal
OBJECTIVE: Ovarian cancer is the seventh leading cause of cancer death worldwide. This is mainly due to late diagnosis and high rate of relapse and resistance following chemotherapy. In the present study, we describe simple and cost-effective method to establish primary culture from ascitic fluid and solid tumor obtained from epithelial ovarian carcinoma patient, which may provide a better tool for in vitro testing of drug sensitivity and designing individualized treatment protocol. METHODS: Complete Dulbecco modified Eagle medium (DMEM) was prepared by supplementing DMEM with 10% fetal bovine serum and antibiotics (ciprofloxacin and amphotericin B)...
August 16, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28816443/characterization-of-ciprofloxacin-permeation-pathways-across-the-porin-ompc-using-metadynamics-and-a-string-method
#7
Jigneshkumar Dahyabhai Prajapati, Carlos José Fernández Solano, Mathias Winterhalter, Ulrich Kleinekathöfer
The rapid spreading of antimicrobial resistance in Gram-negative bacteria has become a major threat for humans as well as animals. As one of the main factors involved, the permeability of the outer membrane has attracted quite some attention recently. However, the knowledge regarding the translocation mechanisms for most available antibiotics is so far rather limited. Here, a theoretical study concerning the diffusion route of ciprofloxacin across the outer membrane porin OmpC from E. coli is presented. To this end, we establish a protocol to characterize meaningful permeation pathways by combining metadynamics with the zero-temperature string method...
August 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28815023/antibiotic-resistance-ability-to-form-biofilm-and-susceptibility-to-copper-alloys-of-selected-staphylococcal-strains-isolated-from-touch-surfaces-in-polish-hospital-wards
#8
Anna Różańska, Agnieszka Chmielarczyk, Dorota Romaniszyn, Małgorzata Bulanda, Monika Walkowicz, Piotr Osuch, Tadeusz Knych
BACKGROUND: Despite the employment of sanitary regimes, contact transmission of the aetiological agents of hospital infections is still exceedingly common. The issue of microbe transmission becomes particularly important when facing multidrug-resistant microorganisms such as methicillin-resistant staphylococci. In the case of deficiencies in cleaning and disinfection procedures, hospital equipment made of copper alloys can play an important role, complementing traditional hospital hygiene procedures...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28814585/a-multiplex-rt-pcr-assay-for-the-simultaneous-identification-of-neisseria-gonorrhoeae-and-its-ciprofloxacin-susceptibility-status
#9
Sumudu R Perera, Nurul H Khan, Irene Martin, Ali Taheri, Rajinder P Parti, Paul N Levett, Greg B Horsman, Anthony Kusalik, Jo-Anne R Dillon
A real time PCR (RT-PCR) assay was designed for the simultaneous identification of N. gonorrhoeae and its ciprofloxacin susceptibility status. A SYBR-Green based multiplex RT-PCR format was used and comprised two different forward primers and a common reverse primer to detect single nucleotide polymorphisms (SNPs) in gyrA of N. gonorrhoeae The primer pairs were evaluated for their sensitivity and specificity with genomic DNA from 254 N. gonorrhoeae isolates (82 were ciprofloxacin susceptible and 172 were ciprofloxacin resistant) and 23 non-N...
August 16, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28813617/environmental-stress-affects-the-formation-of-staphylococcus-aureus-persisters-tolerant-to-antibiotics
#10
Lucie Kubistova, Lukas Dvoracek, Jan Tkadlec, Oto Melter, Irena Licha
The ability to form persisters has been observed in many microorganisms, including Staphylococcus aureus, mainly in the context of chronic infections and the pathogenicity of these microbes. In our research, we have demonstrated that salt or oxidative stress could play a role in the formation of S. aureus persisters outside the host's intracellular interface. We pre-exposed planktonic growing bacterial culture to an oxidative or salt stress and monitored the dynamics of persister formation after ciprofloxacin and gentamicin treatment...
August 16, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28813520/the-frequency-of-class1-and-2-integrons-in-pseudomonas-aeruginosa-strains-isolated-from-burn-patients-in-a-burn-center-of-ahvaz-iran
#11
Azar Dokht Khosravi, Moloudsadat Motahar, Effat Abbasi Montazeri
BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen with the ability to cause severe nosocomial infections and remains a major problem in burn patients. This organism shows a remarkable antimicrobial resistance and is often resistant to multiple antibiotics. Integron genes as mobile genetic elements are playing an important role in the spread of P. aeruginosa antibiotic resistance. This study was aimed to investigate the occurrence of class 1, and 2 integron genes (int1, int2), among P...
2017: PloS One
https://www.readbyqxmd.com/read/28813027/sulfonamide-linked-ciprofloxacin-sulfadiazine-and-amantadine-derivatives-as-a-novel-class-of-inhibitors-of-jack-bean-urease-synthesis-kinetic-mechanism-and-molecular-docking
#12
Pervaiz Ali Channar, Aamer Saeed, Fernando Albericio, Fayaz Ali Larik, Qamar Abbas, Mubashir Hassan, Hussain Raza, Sung-Yum Seo
Sulfonamide derivatives serve as an important building blocks in the drug design discovery and development (4D) process. Ciprofloxacin-, sulfadiazine- and amantadine-based sulfonamides were synthesized as potent inhibitors of jack bean urease and free radical scavengers. Molecular diversity was explored and electronic factors were also examined. All 24 synthesized compounds exhibited excellent potential against urease enzyme. Compound 3e (IC50 = 0.081 ± 0.003 µM), 6a (IC50 = 0.0022 ± 0.0002 µM), 9e (IC50 = 0...
August 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28812009/the-bacteriological-quality-safety-and-antibiogram-of-salmonella-isolates-from-fresh-meat-in-retail-shops-of-bahir-dar-city-ethiopia
#13
Melkamnesh Azage, Mulugeta Kibret
The habit of raw meat consumption in addition to the poor hygienic standards and lack of knowledge contribute to food-borne diseases outbreaks. The objective of this research was to assess the bacterial quality and safety of fresh meat from retail Bahir Dar City, Ethiopia. A total of 30 fresh meat samples were collected from butcher shops. Standard bacteriological methods were used to isolate and enumerate bacteria. Kirby-Bauer disk diffusion method was used for antimicrobial susceptibility testing of Salmonella isolates...
2017: International journal of food science
https://www.readbyqxmd.com/read/28811610/antibiotic-induced-release-of-small-extracellular-vesicles-exosomes-with-surface-associated-dna
#14
Andrea Németh, Norbert Orgovan, Barbara W Sódar, Xabier Osteikoetxea, Krisztina Pálóczi, Katalin É Szabó-Taylor, Krisztina V Vukman, Ágnes Kittel, Lilla Turiák, Zoltán Wiener, Sára Tóth, László Drahos, Károly Vékey, Robert Horvath, Edit I Buzás
Recently, biological roles of extracellular vesicles (which include among others exosomes, microvesicles and apoptotic bodies) have attracted substantial attention in various fields of biomedicine. Here we investigated the impact of sustained exposure of cells to the fluoroquinolone antibiotic ciprofloxacin on the released extracellular vesicles. Ciprofloxacin is widely used in humans against bacterial infections as well as in cell cultures against Mycoplasma contamination. However, ciprofloxacin is an inducer of oxidative stress and mitochondrial dysfunction of mammalian cells...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810312/-analysis-of-infection-and-drug-resistance-in-6-107-cases-of-extrapulmonary-tuberculosis-in-chengdu-area
#15
D M Wang, Q F Li, M Zhu, Y H Xu, J Luo, Y J Li, J Zhong, Z J Wu
Objective: To analyze the infection and drug resistance of extrapulmonary tuberculosis, in order to provide useful references for prevention and treatment of tuberculosis (TB). Methods: A total of 6 107 suspected cases of extrapulmonary tuberculosis, including lymph node, pleural, peritoneal, meningeal, urinary tract, and bone tuberculosis, were collected retrospectively from January 2013 to December 2015 in Public Health Clinical Center of Chengdu. There were 4 033 male and 2 074 female patients, and the average age was 37 years...
August 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28810226/rapid-removal-of-organic-pollutants-by-activation-sulfite-with-ferrate
#16
Jing Zhang, Liang Zhu, Zhenyu Shi, Ying Gao
With the addition of sulfite, almost complete removal of seven out of eight tested contaminants, i.e. benzotriazole, phenol, ciprofloxacin, methyl blue, rhodamine B, methyl orange and sulfamethoxazole, was observed in 30 s except for sulfamethoxazole at pH 9.0, while Fe(VI) alone only resulted in less than 6% removal. In this study, the mechanism of sulfite/Fe(VI) process was explored for the first time. Firstly, sulfite attacks Fe(VI) via a 1-e(-) transfer forming the primary sulfite radical (SO3(-)), then SO3(-) reacts rapidly with oxygen in a diffusion controlled rate to form a much more reactive peroxyl radical SO5(-), which further reacts with HSO3(-) and produces SO4(-)...
July 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28803866/pericarditis-caused-by-campylobacter-fetus-subspecies-fetus-associated-with-ingestion-of-raw-beef-liver
#17
Yoshihiko Kiyasu, Daiki Akiyama, Yoko Kurihara, Hiroshi Koganemaru, Shigemi Hitomi
Campylobacter fetus is an organism residing primarily in the gastrointestinal tracts of cattle and sheep and transmitting to humans through ingestion of contaminated food products or surface water. The organism has caused various extraintestinal infections but, to date, purulent pericarditis due to the organism has rarely been described. We report a case of purulent pericarditis due to C. fetus subsp. fetus, occurring in a patient having several predisposing conditions, including receiving hemodialysis therapy, recent surgery for cecal cancer, and administration of esomeprazole...
August 10, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28803018/short-communication-molecular-characteristics-antimicrobial-susceptibility-and-pathogenicity-of-clinical-nocardia-cyriacigeorgica-isolates-from-an-outbreak-of-bovine-mastitis
#18
Wei Chen, Yongxia Liu, Herman W Barkema, Jian Gao, Jeroen De Buck, John P Kastelic, Gang Liu, Tariq Ali, Muhammad Shahid, Bo Han
The occurrence of nocardial mastitis, mostly in the context of outbreaks, has been reported in many countries. However, there is a paucity of reports regarding detailed characterization of Nocardia cyriacigeorgica from bovine mastitis. Thus, herein we report characteristics, antimicrobial susceptibility patterns, molecular identification, and pathogenicity of N. cyriacigeorgica isolated from an outbreak of clinical mastitis in a dairy herd in northern China. A total of 182 (80.2%) lactating cows had clinical mastitis with severe inflammation and firmness of the udder, reduced milk production, and anorexia, with no apparent clinical response to common antibiotics...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28802854/use-of-axenic-media-to-determine-antibiotic-efficacy-against-coxiella-burnetii
#19
K A Clay, M G Hartley, P Russell, I H Norville
The traditional methods of measuring minimum inhibitory concentration (MIC) of antibiotics against Coxiella burnetii are time consuming and technically difficult. The discovery of axenic media for C. burnetii culture provided an opportunity to determine the feasibility of using both broth dilution and an antimicrobial gradient method (E-test) as a convenient method of measuring MICs. The MIC for a range of antibiotics that have proven or potential use in the treatment of Q-fever, namely doxycycline, ciprofloxacin, levofloxacin, moxifloxacin, co-trimoxazole, were measured...
August 9, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28801381/fluoroquinolone-resistance-mechanisms-by-molecular-epidemiologic-study-of-ciprofloxacin-nonsusceptible-escherichia-coli-sequence-types-isolated-from-clinical-specimens-in-a-tertiary-care-university-hospital-in-korea-emergence-of-clone-st131-2006-2008
#20
Hyung-Seok Yang, Youngjin Kim, Sun Young Cho, You Sun Nam, Tae Sang Oh, Kyung-Sun Park, Hyun-Chul Kim, Hee Joo Lee
To investigate the sequence types (STs) and fluoroquinolone resistance related mutations among ciprofloxacin (CIP)-non-susceptible extended-spectrum β-lactamase (ESBL)-producing E. coli isolated from Korean patients from 2006-2008. The prevalence of fluoroquinolone resistance-determining region (QRDR) mutations in gyrA, gyrB, parC, and parE and plasmid-mediated quinolone resistance (PMQR) genes were also studied. Multilocus sequence typing (MLST) was performed to identify STs. The most common ST was ST131 (33/51, 64...
August 2017: Annals of Clinical and Laboratory Science
keyword
keyword
56162
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"