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https://www.readbyqxmd.com/read/29454207/repeated-treatments-of-ciprofloxacin-and-kresoxim-methyl-alter-their-dissipation-rates-biological-function-and-increase-antibiotic-resistance-in-manured-soil
#1
Hua Fang, Lingxi Han, Houpu Zhang, Yanfei Deng, Qiqing Ge, Jiajia Mei, Zhengnan Long, Yunlong Yu
The dissipation of ciprofloxacin (CIP, 1.0 and 10.0mg/kg) and kresoxim-methyl (KM, 1.0 and 2.0mg/kg) in manure-amended soil, the variations in soil enzyme activities and microbial functional diversities, and CIP-induced bacterial community tolerances were studied using a chromatographic analysis, enzyme colorimetric and titration analyses, and the BIOLOG EcoPlate method. Three successive treatments of individual and combined samples of CIP and KM at low and high concentrations were performed at 60d intervals...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29453863/aeromonas-hydrophila-from-marketed-mullet-mugil-cephalus-in-egypt-pcr-characterization-of-%C3%AE-lactam-resistance-and-virulence-genes
#2
Hazem Ramadan, Nermin Ibrahim, Mohamed Samir, Amany Abd El-Moaty, Tamer Gad
AIMS: Aeromonas hydrophila (A. hydrophila) has been isolated from various fish species in Egypt and is known to carry virulence and antimicrobial resistance genes, which pose risk for public health. The aim of the present study is to report, for the first time, the infection of mullet (Mugil cephalus) with A. hydrophila and to clarify the potential association between antimicrobial resistance and virulence traits encoded in A. hydrophila. METHODS AND RESULTS: In this study, the occurrence of A...
February 17, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29452847/primary-antibiotic-resistance-and-its-relationship-with-caga-and-vaca-genes-in-helicobacter-pylori-isolates-from-algerian-patients
#3
Meryem Bachir, Rachida Allem, Abedelkarim Tifrit, Meriem Medjekane, Amine El-Mokhtar Drici, Mustafa Diaf, Kara Turki Douidi
The epidemiology of Helicobacter pylori resistance to antibiotics is poorly documented in Africa and especially in Algeria. The aim of our study was to determine the antibiotic resistance rates, as well as its possible relationship with VacA and CagA virulence markers of isolates from Algerian patients. One hundred and fifty one H. pylori isolate were obtained between 2012 and 2015 from 200 patients with upper abdominal pain. Antimicrobial susceptibility testing was performed for amoxicillin, clarithromycin, metronidazole, ciprofloxacin, rifampicin and tetracycline...
February 13, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29452500/preparation-of-an-optimized-ciprofloxacin-loaded-chitosan-nanomicelle-with-enhanced-antibacterial-activity
#4
Mahdieh Farhangi, Farzad Kobarfard, Arash Mahboubi, Alireza Vatanara, Seyed Alireza Mortazavi
OBJECTIVE: The objective of present study was to evaluate the effect of lipid structure on physicochemical properties of chitosan-fatty acid nanomicelles and prepare an optimum ciprofloxacin loaded formulation from these conjugates which could enhance the antibacterial effects of drug against some important pathogens like P. aeroginosa. SIGNIFICANCE: Nowadays, resistance in infectious diseases is a growing worldwide concern. Nanocarriers can increase the therapeutic index and consequently reduce the antibiotic resistance...
February 16, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29450997/2-aminoquinazolin-4-3h-one-as-an-organocatalyst-for-the-synthesis-of-tertiary-amines
#5
Maheshwar S Thakur, Onkar S Nayal, Rahul Upadhyay, Neeraj Kumar, Sushil K Maurya
The potential of 2-aminoquinazolin-4(3H)-one as an organocatalyst for the activation of aldehydes via noncovalent interaction for the synthesis of tertiary amines using formic acid as a reducing agent is reported for the first time. The developed protocol demonstrated a dilated substrate scope for aromatic and aliphatic amines with aromatic and aliphatic aldehydes. Furthermore, the current method was also fruitful for the derivatization of ciprofloxacin and its derivative in good to excellent yields.
February 16, 2018: Organic Letters
https://www.readbyqxmd.com/read/29450767/epididymo-orchitis-caused-by-enteric-organisms-in-men-35-years-old-beyond-fluoroquinolones
#6
REVIEW
Laura Ryan, Padraig Daly, Ivor Cullen, Maeve Doyle
Epididymo-orchitis is a common urological condition in men of all ages, causing a unilateral or bilateral swelling of the epididymis and/or testis. It is frequently caused by sexually transmitted infections, Chlamydia trachomatis and Neisseria gonorrheae, as well as common enteric organisms implicated in urinary tract infections. Men over 35 years old may develop epididymo-orchitis associated with enteric organisms, often associated with functional bladder outlet problems such as benign prostatic hyperplasia or urethral stricture disease...
February 15, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29450214/-mycobacterium-abscessus-complex-infections-a-retrospective-cohort-study
#7
Maroun Sfeir, Marissa Walsh, Rossana Rosa, Laura Aragon, Sze Yan Liu, Timothy Cleary, Marylee Worley, Corey Frederick, Lilian M Abbo
Background: Infections caused by Mycobacterium abscessus group strains are usually resistant to multiple antimicrobials and challenging to treat worldwide. We describe the risk factors, treatment, and clinical outcomes of patients in 2 large academic medical centers in the United States. Methods: A retrospective cohort study of hospitalized adults with a positive culture for M. abscessus in Miami, Florida (January 1, 2011, to December 31, 2014). Demographics, comorbidities, the source of infection, antimicrobial susceptibilities, and clinical outcomes were analyzed...
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29445637/virulence-determinants-and-antimicrobial-resistance-patterns-of-vancomycin-resistant-enterococcus-faecium-isolated-from-different-sources-in-southwest-iran
#8
Maniya Arshadi, Mahmood Mahmoudi, Moloud Sadat Motahar, Saber Soltani, Mohammad Reza Pourmand
Background: This study aimed to investigate the incidence of antibiotic-resistance and virulence genes in vancomycin-resistant Enterococcus faecium isolated from different sources in southwest Iran from Mar to Sep 2015. Methods: Overall, 120 E. faecium isolates (80 VRE and 40 vancomycin-susceptible enterococci [VSE] isolates) were obtained from four hospitals. The resistance of the VRE isolates was determined by disk diffusion method. Multiplex PCR was performed to detect the virulence genes carried by the E...
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29442334/utilization-spending-and-price-trends-for-quinolones-in-the-us-medicaid-programs-25-years-experience-1991-2015
#9
Ziyad S Almalki, Xiaomeng Yue, Ying Xia, Patricia R Wigle, Jeff Jianfei Guo
BACKGROUND: Given that the quinolones is one of the antibacterial classes most frequently used to treat patients with bacterial infections in the United States, any change in prescribing patterns of quinolones will impact Medicaid medical expenditures. OBJECTIVES: This study was undertaken to examine trends in utilization, reimbursement, and prices of quinolone antibacterials for the US Medicaid population. METHODS: The publicly available Medicaid State Drug Utilization outpatient pharmacy files were used for this study...
June 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29438980/trimethoprim-use-for-urinary-tract-infection-and-risk-of-adverse-outcomes-in-older-patients-cohort-study
#10
Elizabeth Crellin, Kathryn E Mansfield, Clémence Leyrat, Dorothea Nitsch, Ian J Douglas, Adrian Root, Elizabeth Williamson, Liam Smeeth, Laurie A Tomlinson
OBJECTIVE: To determine if trimethoprim use for urinary tract infection (UTI) is associated with an increased risk of acute kidney injury, hyperkalaemia, or sudden death in the general population. DESIGN: Cohort study. SETTING: UK electronic primary care records from practices contributing to the Clinical Practice Research Datalink linked to the Hospital Episode Statistics database. PARTICIPANTS: Adults aged 65 and over with a prescription for trimethoprim, amoxicillin, cefalexin, ciprofloxacin, or nitrofurantoin prescribed up to three days after a primary care diagnosis of UTI between April 1997 and September 2015...
February 9, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29436416/persistent-pandemic-lineages-of-uropathogenic-escherichia-coli-in-a-college-community-1999-2017
#11
Reina Yamaji, Julia Rubin, Erika Thys, Cindy R Friedman, Lee W Riley
BACKGROUND: Incidence of drug-resistant community-acquired urinary tract infections (CA-UTI) continues to increase worldwide. In 1999-2000, a single lineage of uropathogenic Escherichia coli (UPEC) ST69 caused 51% of trimethoprim-sulfamethoxazole-resistant UTI in a Northern California university community. We compared the clonal distribution of UPEC and its impact on antimicrobial resistance prevalence in the same community during two periods separated by 17 years. METHODS: We analyzed E...
February 7, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29435265/prevalence-and-molecular-characterization-of-oqxab-in-clinical-escherichia-coli-isolates-from-companion-animals-and-humans-in-henan-province-china
#12
Baoguang Liu, Hua Wu, Yajun Zhai, Zhipei He, Huarun Sun, Tian Cai, Dandan He, Jianhua Liu, Shanmei Wang, Yushan Pan, Li Yuan, Gongzheng Hu
Background: The plasmid-encoded multidrug efflux pump oqxAB confers bacterial resistance primarily to olaquindox, quinolones, and chloramphenicol. The aims of this study were to investigate the prevalence of oqxAB among Escherichia coli isolates from dogs, cats, and humans in Henan, China and the susceptibilities of E. coli isolates to common antibiotics. Methods: From 2012 to 2014, a total of 600 samples which included 400 rectal samples and 200 clinical human specimens were tested for the presence of E...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29434938/genetic-characterization-and-in-vitro-activity-of-antimicrobial-combinations-of-multidrug-resistant-acinetobacter-baumannii-from-a-general-hospital-in-china
#13
Fang Chen, Ling Wang, Min Wang, Yixin Xie, Xiaomeng Xia, Xianping Li, Yanhua Liu, Wei Cao, Tingting Zhang, Pengling Li, Min Yang
The present study aimed to develop a rational therapy based on the genetic epidemiology, molecular mechanism evaluation and in vitro antibiotic combinations activity in multidrug-resistant Acinetobacter baumannii (MDRAB). MDRAB was screened by the Kirby-Bauer method. The random amplified polymorphic DNA technique was used to establish genetic fingerprinting, and a series of resistance genes were detected by polymerase chain reaction. Antimicrobial agents including amikacin (AK), cefoperazone/sulbactam (SCF I/II), meropenem (MEM), minocycline (MINO) and ciprofloxacin (CIP) were used to determine the minimum inhibitory concentrations (MICs) and interactions between antibiotics by the broth microdilution method and chequerboard assays...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434822/the-role-of-dexamethasone-in-clinical-pharmaceutical-treatment-for-patients-with-cataract-surgery
#14
Gaokun Zhang, Shuang Liu, Lieying Yang, Yanqing Li
The aim of the present study is to determine the efficacy of dexamethasone (DEX) vs. indomethacin (IND) and ciprofloxacin (CIP) in modulating immediate inflammation following cataract surgery. A total of 644 patients with cataract were recruited and inflammation was investigated during the perioperative period. The management protocol was similar in both groups. Each drug was given four times a day for 30 days starting 7 days prior to surgery. The primary efficacy criteria for evaluation were the reduction in anterior chamber (AC) flare and AC inflammation score, in addition, a different secondary efficacy and safety evaluation criteria were maintained...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29433688/synergism-of-prenylflavonoids-from-morus-alba-root-bark-against-clinical-mrsa-isolates
#15
Guo-Ying Zuo, Cui-Xian Yang, Jun Han, Yu-Qing Li, Gen-Chun Wang
BACKGROUND: Clinical methicillin-resistant Staphylococcus aureus (MRSA) is a thorny problem in current anti-infective therapeutics and a challenge of new drug development. Plant prenylflavonoids possess anti-MRSA activity, but few of the prenylflavonoids have been reported the synergistic anti-MRSA effect when they are used in combination with conventional antibacterial agents. PURPOSE: This study deals with anti-MRSA activity of four prenylflavonoids from the root bark of Morus alba and their synergism with 11 conventional antibacterial agents...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29433110/intraspecific-variability-of-ciprofloxacin-accumulation-tolerance-and-metabolism-in-chinese-flowering-cabbage-brassica-parachinensis
#16
Hai-Ming Zhao, He-Biao Huang, Huan Du, Jing Lin, Lei Xiang, Yan-Wen Li, Quan-Ying Cai, Hui Li, Ce-Hui Mo, Jie-Sheng Liu, Ming-Hung Wong, Dong-Mei Zhou
To investigate the mechanism of genotype differences in ciprofloxacin (CIP) accumulation, this study was designed to compare the tolerance and metabolic responses to CIP exposure between low (Cutai) and high (Sijiu) CIP-accumulation cultivars of Brassica parachinensis. Decreases in biomass and chlorophyll content were significantly greater (p < 0.05) and toxicities were more severe within cell ultrastructures of Cutai compared to Sijiu. A sequential growth test also revealed that Sijiu was more tolerant to CIP stress compared to Cutai...
January 9, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29432938/first-report-on-antimicrobial-resistance-and-molecular-characterization-of-salmonella-enterica-serotype-typhi-isolated-from-human-specimens-in-luanda-angola
#17
Moisés Francisco, Sofia Santos Costa, Adriana Belas, Jorge Ramos, Isabel Couto, Constança Pomba, Miguel Viveiros
OBJECTIVES: Typhoid fever is a common infection in Africa and in spite of scarce surveillance reports, its incidence is commonly considered high by the Angolan Health system. Drug-resistant Salmonella enterica serotype Typhi has emerged, turning antimicrobial susceptibility testing essential to provide clinical guidance. This is the first report analyzing antimicrobial resistance patterns and population structure of the few S. enterica ser. Typhi isolated from patients with Typhoid fever in Luanda, Angola...
February 9, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29432657/clinical-profile-antibiotic-susceptibility-pattern-of-bacterial-isolates-and-factors-associated-with-complications-in-culture-proven-typhoid-patients-admitted-to-an-urban-hospital-in-bangladesh
#18
Halima Khatun, Shoeb Bin Islam, Nurun Nahar Naila, Syed Aminul Islam, Baitun Nahar, Md Nur Haque Alam, Tahmeed Ahmed
OBJECTIVES: Typhoid fever is one of the major causes of morbidity and mortality in typhoid endemic countries like Bangladesh. However, data on the clinical and microbiological profile as well as factors associated with complications of typhoid in Bangladesh are scarce. We intended to characterize the clinical and microbiological profile of culture-proven typhoid fever and to identify factors associated with complications. METHODOLOGY: Retrospective analysis of clinical data from 431 patients with culture-confirmed typhoid fever admitted to Dhaka hospital of International Centre for Diarrhoeal Disease Research, Bangladesh, between January 2010 and December 2014...
February 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29432492/molecular-epidemiology-of-fluoroquinolone-resistant-salmonella-in-africa-a-systematic-review-and-meta-analysis
#19
Getachew Tadesse, Tesfaye S Tessema, Getenet Beyene, Abraham Aseffa
BACKGROUND: Wide-ranging evidence on the occurrence of fluoroquinolone (FQ) resistance genetic determinants in African Salmonella strains is not available. The main objectives of this study were to assess the heterogeneity, estimate pooled proportions and describe the preponderance of FQ-resistance determinants in typhoidal and non-typhoidal Salmonella (NTS) isolates of Africa. METHODS: Genetic and phenotypic data on 6103 Salmonella isolates were considered. Meta- and frequency analyses were performed depending on the number of studies by category, number of isolates and risks of bias...
2018: PloS One
https://www.readbyqxmd.com/read/29432367/the-possible-relationship-between-campylobacter-spp-arcobacter-spp-and-patients-with-ulcerative-colitis
#20
Mustafa Akar, Fuat Aydin, Mustafa A Yurci, Seçil Abay, İhsan Ateş, Kemal Deniz
BACKGROUND AND AIMS: The role of bacterial infection in the pathogenesis of ulcerative colitis (UC) is under investigation. This study aims to (i) determine the prevalence of Campylobacter spp. and Arcobacter spp. in patients with UC, (ii) identify the antibiotic susceptibility of isolated agents, and (iii) investigate the role of these microorganisms in the pathogenesis and/or activation of UC. PATIENTS AND METHODS: Eighty patients with UC and 40 healthy individuals were included in the study...
February 9, 2018: European Journal of Gastroenterology & Hepatology
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