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https://www.readbyqxmd.com/read/27906149/ciprofloxacin-fluocinolone-otovel-for-otitis-media-with-tympanostomy-tubes
#1
(no author information available yet)
No abstract text is available yet for this article.
December 5, 2016: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/27902429/plasmid-mediated-quinolone-resistance-determinants-among-gram-negative-bacteraemia-isolates-a-hidden-threat
#2
Athanasios Margaritis, Irene Galani, Marianthi Chatzikonstantinou, George Petrikkos, Maria Souli
The aim of the study was to investigate the prevalence of PMQR genes in an unselected collection of bloodstream isolates recovered over an 18-month period in a laboratory affiliated to a University Hospital in Athens, Greece and to assess their impact on the in vitro activity of ciprofloxacin and levofloxacin. Eight PMQR genes were screened by PCR and sequencing. All PMQR-positive isolates were submitted to isoelectric focusing for β-lactamase detection, conjugation or transformation, time-kill assays, MPC and inoculum effect evaluation...
November 28, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902427/phenotypic-and-genetic-characterization-of-multi-drug-resistant-staphylococcus-aureus-in-the-tropics-of-southeast-asia
#3
Siti Norayuni Mohd Zulkeflle, Yus Amira Yusaimi, Norio Sugiura, Koji Iwamoto, Masafumi Goto, Motoo Utsumi, Nor'azizi Bin Othman, Zuriati Zakaria, Hirofumi Hara
Antibiotic resistance has become a major public health problem throughout the world. The presence of antibiotic resistant bacteria such as Staphylococcus aureus (S. aureus) and antibiotic resistance genes (ARGs) in hospital wastewater is cause for great concern today. In this study, 276 S. aureus isolates were recovered from hospital wastewater samples in Malaysia. All of the isolates were screened for susceptibility to nine different classes of antibiotics: ampicillin (AMP), ciprofloxacin (CFX), gentamicin (GMN), kanamycin (KMN), erythromycin (ERM), vancomycin (VAN), trimetoprim and sulfamethaxazole (TM-SMZ), chloramphenicol (CMP), tetracycline (TET), and nalidixic acid (NAL)...
November 3, 2016: Microbiology
https://www.readbyqxmd.com/read/27902389/antimicrobial-susceptibility-to-azithromycin-among-salmonella-enterica-typhi-and-paratyphi-a-isolates-from-india
#4
Richa Misra, Kashi N Prasad
Decreased ciprofloxacin susceptibility (DCS) and multi-drug resistance (MDR) in typhoidal Salmonella isolates in areas of endemicity is a significant therapeutic problem. Guidelines for azithromycin disk diffusion and minimal inhibitory concentration (MIC) interpretive criteria for Salmonella enterica serovar Typhi were published recently by CLSI in 2015.We investigated the antimicrobial susceptibility pattern of azithromycin in 100 isolates of Salmonella Typhi (n=80), Paratyphi A (n=18) and B (n=2) recovered from blood stream infections from January 2013 to December 2015...
November 10, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902380/antimicrobial-resistance-profiling-and-molecular-typing-of-methicillin-resistant-staphylococcus-aureus-mrsa-isolated-from-a-malaysian-teaching-hospital
#5
Ainihayati Noordin, Hassriana Fazzila Sapri, Nurul Azirah Mohamad Sani, Shih Kei Leong, Xin-Ee Tan, Toh Leong Tan, Noraziah Mohamad Zin, Hui-Min Neoh, Salasawati Hussin
The annual prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Malaysia has been estimated to be at 30-40% of all S. aureus infections. Nevertheless, data on the antimicrobial resistance and genetic diversity of Malaysian MRSAs remain few. In 2009, we collected 318 MRSA strains from various wards of our teaching hospital located in Kuala Lumpur, the capital city of Malaysia, and performed antimicrobial susceptibility testing on the strains. The strains were then molecularly characterized via SCCmec and virulence gene (cna, sea, seb, sec, sed, see, seg, seh, sei, eta, etb, PVL and TSST-1) typing; a subset of 49 strains isolated from the Intensive Care Unit (ICU) were also typed using Pulsed-Field Gel Electrophoresis (PFGE)...
November 7, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902368/coagulase-negative-staphylococci-pathogenesis-occurrence-of-antibiotic-resistance-genes-and-in-vitro-effects-of-antimicrobial-agents-on-biofilm-growing-bacteria
#6
Ewa Szczuka, Lucyna Jabłońska, Adam Kaznowski
Coagulase-negative staphylococci (CoNS) are opportunistic pathogens that particularly cause infections in patients with implanted medical devices. The present research was performed to study the virulence potential of 53 clinical isolates of Staphylococcus capitis, Staphylococcus auricularis, Staphylococcus lugdunensis, Staphylococcus simulans, Staphylococcus cohnii, and Staphylococcus caprae. All clinical strains were clonally unrelated. Isolates carried genes encoding resistance to β-lactam (mecA) (15%), aminoglycosides aac(6')/aph(2'') (11%), aph (3')-IIIa (15%), ant(4')-Ia (19%) and MLSB erm(A) (4%), erm(B) (13%), erm(C) (41%), msr(A) (11%) antibiotics...
October 19, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27900889/campylobacter-jejuni-strains-coresistant-to-tetracycline-and-ciprofloxacin-in-patients-with-gastroenteritis-in-croatia
#7
Merica Carev, Ana Kovačić, Anita Novak, Marija Tonkić, Ana Jerončić
BACKGROUND: Antibiotic-resistant Campylobacter jejuni strains are rapidly emerging worldwide. Here, we aimed to determine the antibiotic-resistance patterns and genetic structure of C. jejuni from stool samples of symptomatic patients in Dalmatia, the largest Croatian county. METHODS: In a population-based laboratory surveillance programme for campylobacteriosis in Dalmatia from May 2012 to May 2013, C. jejuni (n = 76) were collected from stool samples of all the patients hospitalized with gastroenteritis and matched positive outpatients (n = 77)...
November 30, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27899093/microbiological-profile-of-corneal-ulcer-cases-diagnosed-in-a-tertiary-care-ophthalmological-institute-in-nepal
#8
Sharmila Suwal, Dinesh Bhandari, Pratigya Thapa, Mohan Krishna Shrestha, Jyoti Amatya
BACKGROUND: Corneal ulcer, a major cause of monocular blindness in developing countries has consistently been listed as the major cause of blindness and visual disability in many of the developing nations in Asia, Africa and the Middle East, ranking second only to cataract. This study was carried out to determine the microbiological profile of corneal ulcer cases diagnosed among patients visiting Tilganga Institute of Ophthalmology (TIO), Nepal. METHODS: A total of 101 corneal scrapping samples were tested for routine culture and antibiotic susceptibility at the pathology department of TIO Nepal from April to October 2014...
November 29, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27898796/sorption-of-pharmaceuticals-heavy-metals-and-herbicides-to-biochar-in-the-presence-of-biosolids
#9
Daniel A Bair, Fungai N D Mukome, Inna E Popova, Temitope A Ogunyoku, Allie Jefferson, Daoyuan Wang, Sarah C Hafner, Thomas M Young, Sanjai J Parikh
Agricultural practices are increasingly incorporating recycled waste materials, such as biosolids, to provide plant nutrients and enhance soil functions. Although biosolids provide benefits to soil, municipal wastewater treatment plants receive pharmaceuticals and heavy metals that can accumulate in biosolids, and land application of biosolids can transfer these contaminants to the soil. Environmental exposure of these contaminants may adversely affect wildlife, disrupt microbial communities, detrimentally affect human health through long-term exposure, and cause the proliferation of antibiotic-resistant bacteria...
November 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27898235/postexposure-prophylaxis-after-possible-anthrax-exposure-adherence-and-adverse-events
#10
Leisha D Nolen, Rita M Traxler, Grishma A Kharod, Pallavi A Kache, Stefan Katharios-Lanwermeyer, Katherine A Hendricks, Sean V Shadomy, William A Bower, Dana Meaney-Delman, Henry T Walke
Anthrax postexposure prophylaxis (PEP) was recommended to 42 people after a laboratory incident that involved potential aerosolization of Bacillus anthracis spores in 2 laboratories at the Centers for Disease Control and Prevention in 2014. At least 31 (74%) individuals who initiated PEP did not complete either the recommended 60 days of antimicrobial therapy or the 3-dose vaccine regimen. Among the 29 that discontinued the antimicrobial component of PEP, most (38%) individuals discontinued PEP because of their low perceived risk of infection; 9 (31%) individuals discontinued prophylaxis due to PEP-related minor adverse events, and 10% cited both low risk and adverse events as their reason for discontinuation...
November 29, 2016: Health Security
https://www.readbyqxmd.com/read/27897206/the-incidence-and-drug-resistance-of-clostridium-difficile-infection-in-mainland-china-a-systematic-review-and-meta-analysis
#11
Chenjie Tang, Lunbiao Cui, Yuqiao Xu, Le Xie, Pengfei Sun, Chengcheng Liu, Wenying Xia, Genyan Liu
It has been widely reported that the incidence and severity of Clostridium difficile infection (CDI) have increased dramatically in North America and Europe. However, little is known about CDI in Mainland China. In this study, we aimed to investigate the incidence of CDI and the main epidemic and drug-resistant strains of C. difficile in Mainland China through meta-analysis of related studies published after the year 2010. A total of 51 eligible studies were included. The pooled incidence of toxigenic C. difficile among patients with diarrhoea was 14% (95% CI = 12-16%)...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27894963/longitudinal-surveillance-on-antibiogram-of-important-gram-positive-pathogens-in-southern-china-2001-to-2015
#12
Zhenbo Xu, Jinhong Xie, Brian M Peters, Bing Li, Lin Li, Guangchao Yu, Mark E Shirtliff
OBJECTIVES: A longitudinal surveillance aimed to investigate the antibiogram of three genus of important Gram-positive pathogens in Southern China during 2001-2015. METHODS: A total of 3849 Staphylococcus, Enterococcus and Streptococcus strains were isolated from Southern China during 2001-2015. Bacteria identification was performed by colony morphology, Gram staining, the API commercial kit and the Vitek 2 automated system. Antimicrobial susceptibility testing was determined by disk diffusion method and MIC method...
November 25, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27894961/low-dose-norfloxacin-and-ciprofloxacin-therapy-worsen-leptospirosis-in-hamster
#13
Dianjun Wu, Wenlong Zhang, Tingting Wang, Tao Lin, Xuemin Jin, Xufeng Xie, Jian Guo, Yongguo Cao, Rui Wu
Antibiotics play an important role in the treatment of leptospirosis. Many antibiotics at appropriate concentrations improved the survival rate and alleviated tissue injury, while, when dosing strategies fall below subtherapeutic levels, worse therapeutic effects are seen. In the present study, we investigated the efficacy of low-dose norfloxacin (10, 20 and 30 mg/kg) and ciprofloxacin (1, 2 and 5 mg/kg) against leptospirosis in a hamster model using Leptospira interrogans serovar Icterohaemorrhagiae. The histopathology and bacterial loads of target organs (liver, kidney and lung) were also studied by treatment with norfloxacin at the dose of 10 mg/kg in this model...
November 25, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27894872/synthesis-screening-and-docking-analysis-of-hispolon-analogs-as-potential-antitubercular-agents
#14
Neduri V Balaji, Bollikolla Hari Babu, Gottumukkala V Subbaraju, Kurre Purna Nagasree, Muthyala Murali Krishna Kumar
A series of 20 hispolons/dihydrohispolons were synthesized and characterized by spectral data. These compounds were subjected to in vitro antitubercular activity screening against Mycobacterium tuberculosis (H37Rv) strain. The synthesized compounds showed varied antitubercular activity ranging from 100 to 1.6μg/mL. Among the screened compounds, four compounds (H1, H2, H3 and H15) have shown moderate activity with MIC 25μg/mL. Potent activities were observed for the dihydrohispolon derivative H14 (MIC 1.6μg/mL) followed by H13 (6...
November 18, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27894232/-myoclonus-associated-with-ciprofloxacin-therapy
#15
Esperanza Bueno Juana, Carmen Vicente de Vera Floristán, Anyuli Gracia Gutiérrez, Juan Ignacio Pérez Calvo, Carlos Tejero Juste
No abstract text is available yet for this article.
November 1, 2016: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27893949/phenotypic-and-genotypic-resistance-of-salmonella-isolates-from-healthy-and-diseased-pigs-in-china-during-2008-2015
#16
Yueguang Jiu, Shun Zhu, Sher Bahadar Khan, Mengzhen Sun, Geng Zou, Xianrong Meng, Bin Wu, Rui Zhou, Shaowen Li
The antimicrobial resistance of Salmonella strains is rapidly increasing worldwide, which poses significant threats to animal and public health. In this study, a total of 249 porcine Salmonella isolates collected in China during 2008-2015 were examined, including 155 clinical isolates from diseased pigs and 94 nonclinical isolates from healthy pigs. Based on the minimum inhibitory concentration of seven antimicrobial agents, 96.4% of the isolates were resistant to at least one of the tested antibiotics and 81...
November 28, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27891184/effect-of-antibiotic-pre-treatment-and-pathogen-challenge-on-the-intestinal-microbiota-in-mice
#17
Tadasu Iizumi, Takako Taniguchi, Wataru Yamazaki, Geraldine Vilmen, Alexander V Alekseyenko, Zhan Gao, Guillermo I Perez Perez, Martin J Blaser
BACKGROUND: More than 50 years after the discovery of antibiotics, bacterial infections have decreased substantially; however, antibiotics also may have negative effects such as increasing susceptibility to pathogens. An intact microbiome is an important line of defense against pathogens. We sought to determine the effect of orally administered antibiotics both on susceptibility to pathogens and on impact to the microbiome. We studied Campylobacter jejuni, one of the most common causes of human diarrhea, and Acinetobacter baumannii, which causes wound infections...
2016: Gut Pathogens
https://www.readbyqxmd.com/read/27891157/the-in-vitro-antimicrobial-effects-of-lavandula-angustifolia-essential-oil-in-combination-with-conventional-antimicrobial-agents
#18
Stephanie de Rapper, Alvaro Viljoen, Sandy van Vuuren
The paper focuses on the in vitro antimicrobial activity of Lavandula angustifolia Mill. (lavender) essential oil in combination with four commercial antimicrobial agents. Stock solutions of chloramphenicol, ciprofloxacin, nystatin, and fusidic acid were tested in combination with L. angustifolia essential oil. The antimicrobial activities of the combinations were investigated against the Gram-positive bacterial strain Staphylococcus aureus (ATCC 6538) and Gram-negative Pseudomonas aeruginosa (ATCC 27858) and Candida albicans (ATCC 10231) was selected to represent the yeasts...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27889501/endophthalmitis-after-clear-corneal-cataract-surgery-outcomes-over-two-decades
#19
Nicolas A Yannuzzi, Nancy Si, Nidhi Relhan, Ajay E Kuriyan, Thomas A Albini, Audina M Berrocal, Janet L Davis, William E Smiddy, Justin Townsend, Darlene Miller, Harry W Flynn
PURPOSE: To report the clinical features, causative organisms, and visual acuity (VA) outcomes associated with acute-onset endophthalmitis after clear corneal cataract surgery over the past two decades. DESIGN: Retrospective case series. METHODS: Clinical and microbiology records were reviewed for 63 eyes of 63 patients who presented to a tertiary referral center between 2006 and 2015 with culture-positive endophthalmitis occurring within 6 weeks of clear corneal cataract surgery...
November 23, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27889456/synthesis-of-new-morpholine-connected-pyrazolidine-derivatives-and-their-antimicrobial-antioxidant-and-cytotoxic-activities
#20
Radhakrishnan Surendra Kumar, Meera Moydeen, Salem S Al-Deyab, Aseer Manilal, Akbar Idhayadhulla
A simple and convenient one-pot four-component synthesis of morpholine-connected pyrazolidine derivatives 2a-f and 4a-f was developed using direct metal-free catalysis, with the identities of the synthesized compounds confirmed by IR, NMR ((1)H and (13)C), mass spectrometry, and elemental analysis. The prepared compounds were inspected for antimicrobial, antioxidant, and cytotoxic activities. Antimicrobial and antifungal activities against five bacterial and four fungal pathogens, respectively, were investigated using the disc diffusion technique...
November 14, 2016: Bioorganic & Medicinal Chemistry Letters
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