Carmen Lage, Antonio Sánchez-Rodríguez, María Rivera-Sánchez, María Sierra, Isabel González-Aramburu, Jorge Madera, Manuel Delgado-Alvarado, Sara López-García, Francisco Martínez-Dubarbie, Marta Fernández-Matarrubia, Néstor Martínez-Amador, Isabel Martínez-Rodríguez, Alberto Calvo-Córdoba, Eloy Rodríguez-Rodríguez, Cecilia García-Cena, Pascual Sánchez-Juan, Jon Infante
BACKGROUND: Video-oculography constitutes a highly-sensitive method of characterizing ocular movements, which could detect subtle premotor changes and contribute to the early diagnosis of Parkinson's disease (PD). OBJECTIVE: To investigate potential oculomotor differences between idiopathic PD (iPD) and PD associated with the G2019S variant of LRRK2 (L2PD), as well as to evaluate oculomotor function in asymptomatic carriers of the G2019S variant of LRRK2. METHODS: The study enrolled 129 subjects: 30 PD (16 iPD, 14 L2PD), 23 asymptomatic carriers, 13 non-carrier relatives of L2PD patients, and 63 unrelated HCs...
May 2, 2024: Journal of Parkinson's Disease