Mengliang Hu, Tingting Han, Qiyu Pan, Dongsheng Ni, Fengyi Gao, Liying Wang, Hangjiang Ren, Xiaoyi Zhang, Haoyun Jiao, Yuefeng Wang, Dapeng Dai, Yong Man, Weiqing Tang, Yue Sun, Wei Li, Jian Li, Guoping Li
Glucocorticoids are essential participants in the regulation of lipid metabolism. On a tissue-specific level, glucocorticoid signal is controlled by 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1). Up-regulation of 11β-HSD1 expression during non-alcoholic fatty liver disease (NAFLD) has been previously shown, while 11β-HSD1 inhibition has been shown to reduce hepatic lipids in NAFLD, but the underlying mechanisms remain unclear. Here, in this study, we created in vitro cell culture and in vivo transgenic hepatocyte-specific 11β-HSD1 mouse models of NAFLD to determine the regulatory mechanisms of 11β-HSD1 during lipid metabolism dysfunction...
2022: International Journal of Biological Sciences