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Stephen P J Macdonald, Frances B Kinnear, Glenn Arendts, Kwok M Ho, Daniel M Fatovich
OBJECTIVES: Sepsis is acute organ dysfunction in the setting of infection. An accurate diagnosis is important to guide treatment and disposition. Tissue oxygen saturation (StO2) can be estimated noninvasively by near-infrared spectroscopy (NIRS), and may be an indicator of microcirculatory dysfunction in early sepsis. We aimed to determine the utility of StO2 for sepsis recognition and outcome prediction among patients presenting to the emergency department (ED) with infection. PATIENTS AND METHODS: A multicentre, prospective, observational cohort study recruited patients who were being admitted to hospital with infection...
January 17, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
Burcu Ceylan, Ulku Yapucu Gunes, Mehmet Uyar
AIMS AND OBJECTIVES: This research was conducted to explore the effect of immobility on sacral tissue oxygen saturation in patients lying on a supporting surface in supine position. BACKGROUND: Guidelines in regard to preventing pressure ulcers recommend that patients lying on a standard bed should change their positions every two hours and that patients on a supporting surface should change their positions every four hours. But there is no strong evidence that justifies this practice...
December 8, 2017: Journal of Clinical Nursing
Omar Tujjar, Angelo Raffaele De Gaudio, Lorenzo Tofani, Alessandro Di Filippo
Near-infrared spectroscopy (NIRS) has been used to detect in vivo microvascular alterations by means of a vascular occlusion test. We sought to analyse by NIRS the microcirculatory profile of patients undergoing prolonged tourniquet-induced bloodless condition for extremity surgery, and compare the results with time of ischemia and comorbidities. We conducted a prospective observational study on 42 patients undergoing upper limb surgery. Regional anaesthesia was achieved and ischemia was induced by a tourniquet cuffed at 250 mmHg...
June 2017: Journal of Clinical Monitoring and Computing
Sarah Engbers, Søren R Boysen, Jordan Engbers, Serge Chalhoub
OBJECTIVE: To determine whether a difference exists in tissue oxygen saturation (StO2 ) measurements between 2 near-infrared spectroscopy monitors on the sartorius muscle in healthy dogs. DESIGN: Prospective experimental study. SETTING: University veterinary teaching facility. ANIMALS: Seventeen healthy student volunteered dogs and 4 healthy veterinary medicine teaching dogs. INTERVENTIONS: An Inspectra 650 and INVOS 5100C StO2 probe were simultaneously placed on the medial right and left sartorius muscles of each dog for 2 minutes of real-time recording while standing and in left lateral recumbency...
September 2014: Journal of Veterinary Emergency and Critical Care
Ji-Hyun Lee, Yong-Hee Park, Hee-Soo Kim, Jin-Tae Kim
The aim of this study was to compare tissue oxygen saturation as measured by INVOS® and InSpectra™ during a vascular occlusion test (VOT) in the same subject. Twenty healthy adults were investigated. The INVOS® and InSpectra™ probes were placed randomly on the right and left thenar eminence in the same participant and monitoring of tissue oxygen saturation (SrO2 from INVOS® and StO2 from InSpectra™) were begun. Pneumatic cuffs placed around each upper arm were inflated simultaneously to 30 mmHg above the initial systolic blood pressure and maintained until the tissue oxygen saturation had decreased to 40% or below...
April 2015: Journal of Clinical Monitoring and Computing
Andreas Nygren, Kajsa Rennerfelt, Qiuxia Zhang
The purpose of this study was first to evaluate the near infrared spectroscopy (NIRS) device, INVOS 4100 as a method of measuring exercise and arterial occlusion induced muscle ischemia in human leg, by comparison with InSpectra tissue spectrometer Model 325, and secondly to determine the influence of skin and subcutaneous thickness on the NIRS measurements. Twenty healthy subjects (43 ± 8 years) volunteered for the study. Tissue oxygen saturation (StO2) in the anterior tibial muscle was measured simultaneously with InSpectra Model 325 in one leg and INVOS 4100 in the contralateral leg during an exercise test until muscle exhaustion and arterial occlusion with and without exercise...
February 2014: Journal of Clinical Monitoring and Computing
B B Abdelmalak, J P Cata, A Bonilla, J You, T Kopyeva, J D Vogel, S Campbell, D I Sessler
BACKGROUND: The relationship between tissue oxygen saturation (StO(2)) and serious postoperative complications remains unclear. We tested the hypothesis that perioperative in patients undergoing major non-cardiac surgery is inversely related to serious surgical outcomes. METHODS: We enrolled 124 patients, ASA physical status ≤IV, having elective major non-cardiac surgeries with general anaesthesia. An InSpectra Model 650 StO(2) monitor (Hutchinson Technology, Hutchinson, MN, USA) was used to measure at the thenar eminence throughout surgery and for two postoperative hours...
February 2013: British Journal of Anaesthesia
T-P Simon, T Schuerholz, S P Haugvik, C Forberger, M-A Burmeister, G Marx
BACKGROUND: There is evidence that suggests that early fluid resuscitation is beneficial in the treatment of sepsis. We previously demonstrated that hydroxyethyl starch (HES) 130/0.42 attenuated capillary leakage better than HES 200/0.5. Using a similar porcine fecal sepsis model, we tested the effects of two new synthetic high molecular weight (700 kDa) hydroxyethyl starches with the same molar substitution of 0.42 but with a different C2/C6 ratio compared to 6% HES 130/0.42 on plasma volume (PV), systemic and tissue oxygenation...
January 2013: Minerva Anestesiologica
Cecilia Luengo, Matthieu Resche-Rigon, Charles Damoisel, Sébastien Kerever, Jacques Creteur, Didier Payen
The purpose of this study is to compare Near Infrared Spectroscopy (NIRS) thenar eminence parameters obtained with 2 different devices from the same manufacturer (InSpectra Models 325 and 650, Hutchinson Tech, Min USA), and 2 different probes (15 vs. 25 mm spacing), in healthy volunteers (HV) and ICU patients. Prospective, observational study in ICU setting. Simultaneous, cross over NIRS inter-device comparison and comparison between different probes (25 vs. 15 mm spacing) were done at baseline and during vascular occlusion tests (VOTs)...
February 2013: Journal of Clinical Monitoring and Computing
B Kyle, E Litton, K M Ho
Standard cardiorespiratory monitoring may fail to detect occult tissue ischaemia. This study assessed whether a near infra-red spectroscopy tissue oxygen saturation monitor (InSpectra™) could detect progressive peripheral tissue ischaemia and whether hyperoxia may confound tissue oxygen saturation measurement. Tissue oxygen and arterial oxygen saturations were measured continuously in 30 healthy volunteers, first during a period of progressive increase in inspired oxygen concentration and subsequently during two periods of low- and high-pressure limb ischaemia...
November 2012: Anaesthesia
Alexandre Lima, Michel Egide van Genderen, Eva Klijn, Jan Bakker, Jasper van Bommel
PURPOSE: Near-infrared spectroscopy has been used as a noninvasive monitoring tool for tissue oxygen saturation (StO(2)) in acutely ill patients. This study aimed to investigate whether local vasoconstriction induced by body surface cooling significantly influences thenar StO(2) as measured by InSpectra model 650. METHODS: Eight healthy individuals (age 26 ± 6 years) participated in the study. Using a cooling blanket, we aimed to cool the entire body surface to induce vasoconstriction in the skin without any changes in central temperature...
April 2012: Intensive Care Medicine
Celine Bernet, Olivier Desebbe, Sebastien Bordon, Charlotte Lacroix, Pascal Rosamel, Fadi Farhat, Jean-Jacques Lehot, Maxime Cannesson
OBJECTIVES: Tissue oxygen saturation (StO(2)) assessed using Near Infrared Spectroscopy and its derived parameters during a vascular occlusion test (VOT) can detect microvascular changes in septic shock patients. General anesthesia (GA) impacts microcirculation. Our aim was to study the effects of general anesthesia on StO(2) and StO(2) derived parameters obtained during VOT in patients referred for cardiac surgery. METHODS: We studied 15 patients referred for cardiac surgery before and after induction of GA...
August 2011: Journal of Clinical Monitoring and Computing
Gina Berg, Sue Nyberg, Paul Harrison, Jessica Baumchen, Erin Gurss, Emily Hennes
INTRODUCTION: Immobilization of patients utilizing rigid spine boards (RSBs) is standard practice in the management of trauma patients. Pressure ulcers have been associated with prolonged immobilization, and the possibility exists that formation may begin when the patient is initially immobilized on the RSB. The effects may not be fully recognized because of limited research on the direct tissue effects of prolonged immobilization. Near-infrared spectroscopy is an emerging tool to measure peripheral tissue oxygen saturation (StO(2))...
October 2010: Prehospital Emergency Care
Raghavendra Govinda, Yusuke Kasuya, Endrit Bala, Ramatia Mahboobi, Jagan Devarajan, Daniel I Sessler, Ozan Akça
BACKGROUND: Subcutaneous oxygen partial pressure is one of several determinants of surgical site infections (SSIs). However, tissue partial pressure is difficult to measure and requires invasive techniques. We tested the hypothesis that early postoperative tissue oxygen saturation (Sto(2)) measured with near-infrared spectroscopy predicts SSI. METHODS: We evaluated Sto(2) in 116 patients undergoing elective colon resection. Saturation was measured near the surgical incision, at the upper arm, and at the thenar muscle with an InSpectra™ tissue spectrometer model 650 (Hutchinson Technology Inc...
October 2010: Anesthesia and Analgesia
Rick Bezemer, Alexandre Lima, Dean Myers, Eva Klijn, Michal Heger, Peter T Goedhart, Jan Bakker, Can Ince
INTRODUCTION: To assess potential metabolic and microcirculatory alterations in critically ill patients, near-infrared spectroscopy (NIRS) has been used, in combination with a vascular occlusion test (VOT), for the non-invasive measurement of tissue oxygen saturation (StO2), oxygen consumption, and microvascular reperfusion and reactivity. The methodologies for assessing StO2 during a VOT, however, are very inconsistent in the literature and, consequently, results vary from study to study, making data comparison difficult and potentially inadequate...
2009: Critical Care: the Official Journal of the Critical Care Forum
Hernando Gómez, Jaume Mesquida, Peter Simon, Hyung Kook Kim, Juan C Puyana, Can Ince, Michael R Pinsky
INTRODUCTION: Tissue oxygen saturation (StO2) and the vascular occlusion test (VOT) can identify tissue hypoperfusion in trauma and sepsis. However, the technique is neither standardized nor uses the same monitoring site. We hypothesized that baseline and VOT StO2 would be different in the forearm (F) and thenar eminence (TH) and that different minimal StO2 values during the VOT would result in different reoxygenation rates (ReO2). METHODS: StO2 and its change during the VOT were simultaneously measured in the F and TH, with 15 mm and 25 mm probes, using the 325 InSpectra monitor in 18 healthy, adult volunteers...
2009: Critical Care: the Official Journal of the Critical Care Forum
Dean Myers, Michelle McGraw, Mark George, Kristine Mulier, Greg Beilman
INTRODUCTION: The tissue hemoglobin index (THI) is a hemoglobin signal strength metric provided on the InSpectra StO2 Tissue Oxygenation Monitor, Model 650. There is growing interest regarding the physiologic meaning of THI and whether a clinically useful correlation between THI and blood hemoglobin concentration exists. A series of in vitro and in vivo experiments was performed to evaluate whether THI has potential utility beyond its primary purpose of helping InSpectra device users optimally position a StO2 sensor over muscle tissue...
2009: Critical Care: the Official Journal of the Critical Care Forum
Jacques Creteur, Ana Paula Neves, Jean-Louis Vincent
INTRODUCTION: The aim of this study was to evaluate the effects of red blood cell (RBC) transfusions on muscle tissue oxygenation, oxygen metabolism and microvascular reactivity in critically ill patients using near-infrared spectroscopy (NIRS) technology. METHODS: This prospective, observational study included 44 consecutive patients hospitalized in the 31-bed, medical-surgical intensive care unit of a university hospital with anemia requiring red blood cell transfusion...
2009: Critical Care: the Official Journal of the Critical Care Forum
Ran D Goldman, Aly Shah Aziz, Linda Marques, Alex L Rogovik
BACKGROUND: : Near-infrared spectroscopy is a new noninvasive method of monitoring oxygen saturation at a tissue level. The purpose of this study was to evaluate new near-infrared tissue spectrometer InSpectra (Hutchinson Technology Inc.) in children and to determine preferable areas of the body to measure tissue oxygen saturation (StO2). METHODS: : Prospective study at a pediatric emergency department. Children aged 0 years to 17 years with no respiratory distress participated in this study...
March 2010: Journal of Trauma
Sam J Thomson, Matthew L Cowan, Daniel M Forton, Sarah J Clark, Saif Musa, Michael Grounds, Tony M Rahman
BACKGROUND: The circulatory dysfunction associated with cirrhosis is well described. Reduced systemic vascular resistance and high cardiac output are the main features of the hyperdynamic state, but involvement of the peripheral microcirculation in this process is poorly understood. Near infrared spectroscopy (NIRS) has been used to assess muscle tissue oxygenation (StO(2)) in haemorrhagic and septic shock. Vascular occlusion testing (VOT) can produce dynamic changes in StO(2) which represent tissue oxygen extraction, delivery, and hence, surrogate markers of microvascular function...
March 2010: Liver International: Official Journal of the International Association for the Study of the Liver
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