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https://www.readbyqxmd.com/read/29776456/pancreatitis-and-systemic-coronavirus-infection-in-a-ferret-mustela-putorius-furo
#1
Sarah E Wills, Hugues H Beaufrère, Brigitte A Brisson, Russell S Fraser, Dale A Smith
A 1-y-old spayed female ferret (Mustela putorius furo) was referred for additional diagnostic evaluation after physicalexamination by the referring veterinarian revealed a cranial abdominal mass. The ferret had a 2-wk history of inappetence,weight loss, and lethargy. On presentation, the ferret was thin, and an approximately 3-cm mass was palpable in the cranialabdomen. No other abnormalities were noted. Abdominal ultrasonography confirmed the presence of a soft-tissue structure, with a moderate blood supply and mesenteric lymphadenopathy...
May 18, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29774862/ferrets-as-models-for-influenza-virus-transmission-studies-and-pandemic-risk-assessments
#2
Jessica A Belser, Wendy Barclay, Ian Barr, Ron A M Fouchier, Ryota Matsuyama, Hiroshi Nishiura, Malik Peiris, Charles J Russell, Kanta Subbarao, Huachen Zhu, Hui-Ling Yen
The ferret transmission model is extensively used to assess the pandemic potential of emerging influenza viruses, yet experimental conditions and reported results vary among laboratories. Such variation can be a critical consideration when contextualizing results from independent risk-assessment studies of novel and emerging influenza viruses. To streamline interpretation of data generated in different laboratories, we provide a consensus on experimental parameters that define risk-assessment experiments of influenza virus transmissibility, including disclosure of variables known or suspected to contribute to experimental variability in this model, and advocate adoption of more standardized practices...
June 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29772966/variability-of-serum-aldosterone-concentrations-in-pet-ferrets-mustela-putorius-furo
#3
Nicola Di Girolamo, Kellie Fecteau, Alessandra Carnimeo, Laura Bongiovanni, Federico Fracassi, Gloria Isani, Paolo Selleri
OBJECTIVE To explore sources of serum aldosterone concentration variability in a population of healthy and diseased ferrets, determine a preliminary 1 -sided reference interval for serum aldosterone concentration in healthy ferrets, and identify a decision limit to differentiate healthy from diseased ferrets on the basis of serum aldosterone concentration. DESIGN Prospective threshold definition and diagnostic accuracy study. ANIMALS 78 healthy (n = 56) and diseased (22) ferrets. PROCEDURES Serum aldosterone concentrations were measured on consecutively admitted ferrets, and an upper reference limit for aldosterone concentrations was established...
June 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29769705/possible-role-of-the-nipah-virus-v-protein-in-the-regulation-of-the-interferon-beta-induction-by-interacting-with-ubx-domain-containing-protein1
#4
Shotaro Uchida, Ryo Horie, Hiroki Sato, Chieko Kai, Misako Yoneda
Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes lethal encephalitis in humans. We previously reported that the V protein, one of the three accessory proteins encoded by the P gene, is one of the key determinants of the pathogenesis of NiV in a hamster infection model. Satterfield B.A. et al. have also revealed that V protein is required for the pathogenicity of henipavirus in a ferret infection model. However, the complete functions of NiV V have not been clarified. In this study, we identified UBX domain-containing protein 1 (UBXN1), a negative regulator of RIG-I-like receptor signaling, as a host protein that interacts with NiV V...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29746640/investigating-viral-interference-between-influenza-a-virus-and-human-respiratory-syncytial-virus-in-a-ferret-model-of-infection
#5
Kok Fei Chan, Louise A Carolan, Daniil Korenkov, Julian Druce, James McCaw, Patrick C Reading, Ian G Barr, Karen L Laurie
Epidemiological studies have observed that the seasonal peak incidence of influenza virus infection is sometimes separate from the peak incidence of human respiratory syncytial virus (hRSV) infection, with the peak incidence of hRSV infection delayed. This is proposed to be due to viral interference, whereby infection with one virus prevents or delays infection with a different virus. We investigated viral interference between hRSV and 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09) in the ferret model...
May 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29744628/impact-of-sylvatic-plague-vaccine-on-non-target-small-rodents-in-grassland-ecosystems
#6
Gebbiena M Bron, Katherine L D Richgels, Michael D Samuel, Julia E Poje, Faye Lorenzsonn, Jonathan P Matteson, Jesse T Boulerice, Jorge E Osorio, Tonie E Rocke
Oral vaccination is an emerging management strategy to reduce the prevalence of high impact infectious diseases within wild animal populations. Plague is a flea-borne zoonosis of rodents that often decimates prairie dog (Cynomys spp.) colonies in the western USA. Recently, an oral sylvatic plague vaccine (SPV) was developed to protect prairie dogs from plague and aid recovery of the endangered black-footed ferret (Mustela nigripes). Although oral vaccination programs are targeted toward specific species, field distribution of vaccine-laden baits can result in vaccine uptake by non-target animals and unintended indirect effects...
May 9, 2018: EcoHealth
https://www.readbyqxmd.com/read/29740451/therapeutic-administration-of-broadly-neutralizing-fi6-antibody-reveals-lack-of-interaction-between-human-igg1-and-pig-fc-receptors
#7
Sophie B Morgan, Barbara Holzer, Johanneke D Hemmink, Francisco J Salguero, John C Schwartz, Gloria Agatic, Elisabetta Cameroni, Barbara Guarino, Emily Porter, Pramila Rijal, Alain Townsend, Bryan Charleston, Davide Corti, Elma Tchilian
Influenza virus infection is a significant global health threat. Because of the lack of cross-protective universal vaccines, short time window during which antivirals are effective and drug resistance, new therapeutic anti-influenza strategies are required. Broadly, cross-protective antibodies that target conserved sites in the hemagglutinin (HA) stem region have been proposed as therapeutic agents. FI6 is the first proven such monoclonal antibody to bind to H1-H16 and is protective in mice and ferrets. Multiple studies have shown that Fc-dependent mechanisms are essential for FI6 in vivo efficacy...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29725291/neural-progenitors-in-the-developing-neocortex-of-the-northern-tree-shrew-tupaia-belangeri-show-a-closer-relationship-to-gyrencephalic-primates-than-to-lissencephalic-rodents
#8
Sebastian Römer, Hannah Bender, Wolfgang Knabe, Elke Zimmermann, Rudolf Rübsamen, Johannes Seeger, Simone A Fietz
The neocortex is the most complex part of the mammalian brain and as such it has undergone tremendous expansion during evolution, especially in primates. The majority of neocortical neurons originate from distinct neural stem and progenitor cells (NPCs) located in the ventricular and subventricular zone (SVZ). Previous studies revealed that the SVZ thickness as well as the abundance and distribution of NPCs, especially that of basal radial glia (bRG), differ markedly between the lissencephalic rodent and gyrencephalic primate neocortex...
2018: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29723586/consumption-and-exposure-assessment-to-toothpaste-in-french-families
#9
Marie-Pierre Gomez-Berrada, Anne-Sophie Ficheux, Inès Boudières, Myriam Chiter, Aurélie Rielland, Dominique De Javel, Alain-Claude Roudot, Pierre-Jacques Ferret
The aim of the study was to assess the consumption and the exposure to toothpaste in French families leaving the consumers free to use their own product at home according to their habits. Consumption data were collected on 104 families. 206 adults (103 women and 103 men) and 195 children aged 2-17 participated in the study. Differences in toothpaste consumption depending on gender and on age were highlighted. As an example, frequency data were higher in adult women (2.0 day-1 on average) than in adult men (1...
April 30, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29723100/resistance-to-deltamethrin-in-prairie-dog-cynomys-ludovicianus-fleas-in-the-field-and-in-the-laboratory
#10
David A Eads, Dean E Biggins, Jonathan Bowser, Janet C McAllister, Randall L Griebel, Eddie Childers, Travis M Livieri, Cristi Painter, Lindsey Sterling Krank, Kristy Bly
Sylvatic plague poses a substantial risk to black-tailed prairie dogs ( Cynomys ludovicianus) and their obligate predator, the black-footed ferret ( Mustela nigripes). The effects of plague on prairie dogs and ferrets are mitigated using a deltamethrin pulicide dust that reduces the spread of plague by killing fleas, the vector for the plague bacterium. In portions of Conata Basin, Buffalo Gap National Grasslands, and Badlands National Park, South Dakota, 0.05% deltamethrin has been infused into prairie dog burrows on an annual basis since 2005...
May 3, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29720231/nimodipine-treatment-does-not-benefit-juvenile-ferrets-with-kaolin-induced-hydrocephalus
#11
Domenico L Di Curzio, Xiaoyan Mao, Aidan Baker, Marc R Del Bigio
Prior research on 3-week hydrocephalic rats showed that behavioral deficits and white matter damage could be reduced by treatment with Ca2+ channel blocker nimodipine. We hypothesized that treatment with nimodipine would be also beneficial to young ferrets with kaolin-induced hydrocephalus. Hydrocephalus was induced at 14 days of age and animals were treated either with vehicle, low dose nimodipine (3.2 mg/kg/day), or high dose nimodipine (16 mg/kg/day) for 2 weeks from 38 to 52 days age. Hydrocephalic ferrets developed progressive ventriculomegaly, behavioral changes, and in some cases cortical blindness...
May 3, 2018: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29717637/validation-of-a-radioimmunoassay-of-serum-trypsin-like-immunoreactivity-in-ferrets
#12
Cory S Bridges, Pamela S Miller, Jonathan A Lidbury, Jan S Suchodolski, Yaling Yi, John F Engelhardt, Jörg M Steiner
Measurement of serum trypsin-like immunoreactivity (TLI) is used to assess exocrine pancreatic function in dogs and cats. Ferrets ( Mustela putorius furo) serve as valuable animal models for human diseases such as cystic fibrosis and other pulmonary diseases, and may be a useful model of other diseases including pancreatitis. We developed and analytically validated a competitive radioimmunoassay (RIA) for measurement of TLI in ferret serum by determination of analytical sensitivity, assay linearity, accuracy of spiking recovery, precision, and reproducibility...
April 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29709902/development-of-a-quantitative-real-time-rt-pcr-assay-for-detecting-taiwan-ferret-badger-rabies-virus-in-ear-tissue-of-ferret-badgers-and-mice
#13
Ai-Ping Hsu, Chun-Hsien Tseng, Yi-Ta Lu, Yu-Hua Shih, Chung-Hsi Chou, Re-Shang Chen, Kuo-Jung Tsai, Wen-Jane Tu, Florence Cliquet, Hsiang-Jung Tsai
In 2013, the first case of Taiwan ferret badger rabies virus (RABV-TWFB) infection was reported in Formosan ferret badgers, and two genetic groups of the virus were distinguished through phylogenetic analysis. To detect RABV-TWFB using a sensitive nucleic acid-based method, a quantitative real-time reverse transcription polymerase chain reaction targeting the conserved region of both genetic groups of RABV-TWFB was developed. This method had a limit of detection (LOD) of 40 RNA copies/reaction and detected viral RNA in brain and ear tissue specimens of infected and dead Formosan ferret badgers and mice with 100% sensitivity and specificity...
April 30, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29703861/comparison-of-heterosubtypic-protection-in-ferrets-and-pigs-induced-by-a-single-cycle-influenza-vaccine
#14
Barbara Holzer, Sophie B Morgan, Yumi Matsuoka, Matthew Edmans, Francisco J Salguero, Helen Everett, Sharon M Brookes, Emily Porter, Ronan MacLoughlin, Bryan Charleston, Kanta Subbarao, Alain Townsend, Elma Tchilian
Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a minimal Ab response to hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs and ferrets from heterosubtypic H1N1 influenza challenge. Aerosol administration of S-FLU to pigs induced lung tissue-resident memory T cells and reduced lung pathology but not the viral load...
April 27, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29701519/chylous-ascites-associated-with-abdominal-trauma-and-intestinal-resection-anastomosis-in-a-pet-ferret-mustela-putorius-furo
#15
Lucile Chassang, Isabelle Langlois, Pauline Loos, Mila Freire, Elizabeth O'Toole
CASE DESCRIPTION A 10-week-old 0.73-kg (1.6-lb) castrated male domestic ferret (Mustela putorius furo) was referred for exploratory laparotomy because of pneumoperitoneum and possible septic peritonitis after being bitten by the owner's dog. CLINICAL FINDINGS Abdominal exploration revealed a large laceration of the duodenum, tears of the jejunal mesentery, and 2 small tears in the abdominal wall. Chylous abdominal effusion developed 48 hours after surgery. TREATMENT AND OUTCOME Postoperative care included supportive treatment, analgesia, and antimicrobials...
May 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29673075/limited-pathogenicity-and-transmissibility-of-korean-highly-pathogenic-avian-influenza-h5n6-clade-2-3-4-4-in-ferrets
#16
J-Y Noh, D-H Lee, S-S Yuk, J-H Kwon, E-O Tseren-Ochir, W-T Hong, J-H Jeong, S Jeong, C-S Song
The pathogenicity and transmissibility of a reassortant clade 2.3.4.4 avian influenza A (H5N6) virus were evaluated in ferrets. Virus excretion was detected in the upper respiratory tract, but the ferrets did not show any clinical signs of infection. Transmission did not occur between cohoused or respiratory droplet-contact ferrets.
April 19, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29672912/discerning-bias-in-forensic-psychological-reports-in-insanity-cases
#17
Tess M S Neal
This project began as an attempt to develop systematic, measurable indicators of bias in written forensic mental health evaluations focused on the issue of insanity. Although forensic clinicians observed in this study did vary systematically in their report-writing behaviors on several of the indicators of interest, the data are most useful in demonstrating how and why bias is hard to ferret out. Naturalistic data were used in this project (i.e., 122 real forensic insanity reports), which in some ways is a strength...
April 19, 2018: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/29672713/imprinting-of-repeated-influenza-a-h3-exposures-on-antibody-quantity-and-antibody-quality-implications-on-seasonal-vaccine-strain-selection-and-vaccine-performance
#18
Martina Kosikova, Lei Li, Peter Radvak, Zhiping Ye, Xiu-Feng Wan, Hang Xie
Background: Reduced seasonal influenza vaccine effectiveness (VE) was observed in individuals who received repeated annual vaccinations. Pre-existing influenza antibody levels were also found inversely correlated with post-vaccination titers. These reports suggest that pre-existing immunity may affect contemporary seasonal vaccine performance. Methods: Influenza A/H3 specific cross-reactivity of post-vaccination sera from humans with or without pre-existing immunity was assessed by hemagglutination inhibition (HAI) assay...
April 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29666412/extensive-t-cell-cross-reactivity-between-diverse-seasonal-influenza-strains-in-the-ferret-model
#19
Adrian J Reber, Nedzad Music, Jin Hyang Kim, Shane Gansebom, Jufu Chen, Ian York
Influenza virus causes widespread, yearly epidemics by accumulating surface protein mutations to escape neutralizing antibodies established from prior exposure. In contrast to antibody epitopes, T cell mediated immunity targets influenza epitopes that are more highly conserved and have potential for cross-protection. The extent of T cell cross-reactivity between a diverse array of contemporary and historical influenza strains was investigated in ferrets challenged with 2009 pandemic H1N1 influenza or the seasonal H3N2 strain, A/Perth/16/2009...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29664120/morphological-heterogeneity-among-corticogeniculate-neurons-in-ferrets-quantification-and-comparison-with-a-previous-report-in-macaque-monkeys
#20
J Michael Hasse, Elise M Bragg, Allison J Murphy, Farran Briggs
The corticogeniculate (CG) pathway links the visual cortex with the lateral geniculate nucleus (LGN) of the thalamus and is the first feedback connection in the mammalian visual system. Whether functional connections between CG neurons and LGN relay neurons obey or ignore the separation of feedforward visual signals into parallel processing streams is not known. Accordingly, there is some debate about whether CG neurons are morphologically heterogeneous or homogenous. Here we characterized the morphology of CG neurons in the ferret, a visual carnivore with distinct feedforward parallel processing streams, and compared the morphology of ferret CG neurons with CG neuronal morphology previously described in macaque monkeys (Briggs et al, 2016)...
April 17, 2018: Journal of Comparative Neurology
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