keyword
MENU ▼
Read by QxMD icon Read
search

Ferret

keyword
https://www.readbyqxmd.com/read/29155788/use-of-synaptic-zinc-histochemistry-to-reveal-different-regions-and-laminae-in-the-developing-and-adult-brain
#1
Reem Khalil, Jonathan B Levitt
Characterization of anatomical and functional brain organization and development requires accurate identification of distinct neural circuits and regions in the immature and adult brain. Here we describe a zinc histochemical staining procedure that reveals differences in staining patterns among different layers and brain regions. Others have utilized this procedure not only to reveal the distribution of zinc-containing neurons and circuits in the brain, but also to successfully delineate areal and laminar boundaries in the developing and adult brain in several species...
October 29, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29153109/non-invasive-blood-pressure-measurement-in-ferrets-mustela-putorius-furo-using-high-definition-oscillometry
#2
Y R A van Zeeland, A Wilde, I H Bosman, J J Uilenreef, B Egner, N J Schoemaker
This study was conducted to validate the use of high definition oscillometry (HDO) for non-invasive blood pressure (NIBP) measurements in ferrets and to establish reference ranges for NIBP in minimally sedated, healthy, young adult ferrets (<4years of age). The bias, limits of agreement and correlation for HDO compared to direct arterial blood pressure (DABP) measurement were established in 14 anaesthetised ferrets. Measurements were performed at the forelimb, hind limb and tail under hypo- (<110mmHg), normo- (110-170mmHg) and hypertensive (>170mmHg) conditions...
October 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29151586/h7n9-virulent-mutants-detected-in-chickens-in-china-pose-an-increased-threat-to-humans
#3
Jianzhong Shi, Guohua Deng, Huihui Kong, Chunyang Gu, Shujie Ma, Xin Yin, Xianying Zeng, Pengfei Cui, Yan Chen, Huanliang Yang, Xiaopeng Wan, Xiurong Wang, Liling Liu, Pucheng Chen, Yongping Jiang, Jinxiong Liu, Yuntao Guan, Yasuo Suzuki, Mei Li, Zhiyuan Qu, Lizheng Guan, Jinkai Zang, Wenli Gu, Shuyu Han, Yangming Song, Yuzhen Hu, Zeng Wang, Linlin Gu, Wenyu Yang, Libin Liang, Hongmei Bao, Guobin Tian, Yanbing Li, Chuanling Qiao, Li Jiang, Chengjun Li, Zhigao Bu, Hualan Chen
Certain low pathogenic avian influenza viruses can mutate to highly pathogenic viruses when they circulate in domestic poultry, at which point they can cause devastating poultry diseases and severe economic damage. The H7N9 influenza viruses that emerged in 2013 in China had caused severe human infections and deaths. However, these viruses were nonlethal in poultry. It is unknown whether the H7N9 viruses can acquire additional mutations during their circulation in nature and become lethal to poultry and more dangerous for humans...
October 24, 2017: Cell Research
https://www.readbyqxmd.com/read/29147963/inappropriate-anticholinergic-drugs-prescriptions-in-older-patients-analysing-a-hospital-database
#4
Laurie Ferret, Gregoire Ficheur, Emeline Delaviez, Michel Luyckx, Sophie Quenton, Regis Beuscart, Emmanuel Chazard, Jean-Baptiste Beuscart
Background Although many anticholinergics are inappropriate in older patients, the prescription of these drugs in a hospital setting has not been extensively studied. Objective To describe prescriptions of anticholinergic drugs in terms of frequency, at risk situations and constipation in hospitalized, older adults. Setting Using a database from a French general hospital (period 2009-2013), we extracted information on 14,090 hospital stays by patients aged 75 and over. Methods Anticholinergic drug prescriptions were automatically detected, with a focus on prescriptions in three well-known at-risk situations: falls, dementia, and benign prostatic hyperplasia...
November 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29146026/vaccination-of-ferrets-for-rabies-and-distemper
#5
REVIEW
Laura L Wade
Companion ferrets need to be vaccinated against 2 viral diseases that cause neurologic illness: canine distemper and rabies. Although not common in ferrets, both viruses are fatal in ferrets and rabies virus is also fatal in humans. In this article, we provide a basic review of the 2 diseases, highlighting key neurologic concerns. We also review and update current vaccine concerns from a practitioner's perspective, including available vaccines, vaccine schedule recommendations, vaccine reactions, and risk assessment...
January 2018: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/29145498/antigenicity-of-the-2015-2016-seasonal-h1n1-human-influenza-virus-ha-and-na-proteins
#6
Amelia M Clark, Marta L DeDiego, Christopher S Anderson, Jiong Wang, Hongmei Yang, Aitor Nogales, Luis Martinez-Sobrido, Martin S Zand, Mark Y Sangster, David J Topham
Antigenic drift of the hemagglutinin (HA) and neuraminidase (NA) influenza virus proteins contributes to reduced vaccine efficacy. To analyze antigenic drift in human seasonal H1N1 viruses derived from the 2009 pandemic H1N1 virus (pH1N1-like viruses) accounts for the limited effectiveness (around 40%) of vaccination against pH1N1-like viruses during the 2015-2016 season, nasal washes/swabs collected from adult subjects in the Rochester, NY area, were used to sequence and isolate the circulating viruses. The HA and NA proteins from viruses circulating during the 2015-2016 season encoded eighteen and fourteen amino acid differences, respectively, when compared to A/California/04/2009, a strain circulating at the origin of the 2009 pandemic...
2017: PloS One
https://www.readbyqxmd.com/read/29143465/migratory-birds-in-southern-brazil-are-a-source-of-multiple-avian-influenza-virus-subtypes
#7
Jansen de Araujo, Maria Virgínia Petry, Thomas Fabrizio, David Walker, Tatiana Ometto, Luciano M Thomazelli, Angelo L Scherer, Patricia P Serafini, Isaac S Neto, Scott Krauss, Robert G Webster, Richard J Webby, Edison L Durigon
BACKGROUND: There is insufficient knowledge about the relation of avian influenza virus (AIV) to migratory birds in South America. Accordingly, we studied samples obtained over a 4-year period (2009-2012) from wild birds at a major wintering site in Southern Brazil. METHODS: We obtained 1212 oropharyngeal/cloacal samples from wild birds at Lagoa do Peixe National Park and screened them for influenza A virus by RT-PCR amplification of the matrix gene. Virus isolates were subjected to genomic sequencing and antigenic characterization...
November 15, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29136104/focal-suppression-of-distractor-sounds-by-selective-attention-in-auditory-cortex
#8
Zachary P Schwartz, Stephen V David
Auditory selective attention is required for parsing crowded acoustic environments, but cortical systems mediating the influence of behavioral state on auditory perception are not well characterized. Previous neurophysiological studies suggest that attention produces a general enhancement of neural responses to important target sounds versus irrelevant distractors. However, behavioral studies suggest that in the presence of masking noise, attention provides a focal suppression of distractors that compete with targets...
November 9, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29132503/gyrification-of-the-cerebral-cortex-requires-fgf-signaling-in-the-mammalian-brain
#9
Naoyuki Matsumoto, Yohei Shinmyo, Yoshie Ichikawa, Hiroshi Kawasaki
Although it has been believed that the evolution of cortical folds was a milestone, allowing for an increase in the number of neurons in the cerebral cortex, the mechanisms underlying the formation of cortical folds are largely unknown. Here we show regional differences in the expression of fibroblast growth factor receptors (FGFRs) in the developing cerebral cortex of ferrets even before cortical folds are formed. By taking the advantage of our in utero electroporation technique for ferrets, we found that cortical folding was impaired in the ferret cerebral cortex when FGF signaling was inhibited...
November 14, 2017: ELife
https://www.readbyqxmd.com/read/29131858/the-composition-and-initial-evaluation-of-a-grimace-scale-in-ferrets-after-surgical-implantation-of-a-telemetry-probe
#10
Marsinah L Reijgwart, Nico J Schoemaker, Riccardo Pascuzzo, Matthew C Leach, Melanie Stodel, Loes de Nies, Coenraad F M Hendriksen, Miriam van der Meer, Claudia M Vinke, Yvonne R A van Zeeland
Reliable recognition of pain is difficult in ferrets as many currently available parameters are non-specific, inconsistent and/or impractical. Grimace scales have successfully been applied to assess pain in different animal species and might also be applicable to ferrets. To compose a Ferret Grimace Scale (FGS), we studied the facial musculature of ferrets and compared lateral photographs of 19 ferret faces at six time points before and after intraperitoneal telemetry probe implantation. We identified the Action Units (AUs) orbital tightening, nose bulging, cheek bulging, ear changes and whisker retraction as potential indicators of pain in ferrets...
2017: PloS One
https://www.readbyqxmd.com/read/29114043/subplate-neurons-are-the-first-cortical-neurons-to-respond-to-sensory-stimuli
#11
Jessica M Wess, Amal Isaiah, Paul V Watkins, Patrick O Kanold
In utero experience, such as maternal speech in humans, can shape later perception, although the underlying cortical substrate is unknown. In adult mammals, ascending thalamocortical projections target layer 4, and the onset of sensory responses in the cortex is thought to be dependent on the onset of thalamocortical transmission to layer 4 as well as the ear and eye opening. In developing animals, thalamic fibers do not target layer 4 but instead target subplate neurons deep in the developing white matter...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29109430/the-first-draft-reference-genome-of-the-american-mink-neovison-vison
#12
Zexi Cai, Bent Petersen, Goutam Sahana, Lone B Madsen, Knud Larsen, Bo Thomsen, Christian Bendixen, Mogens Sandø Lund, Bernt Guldbrandtsen, Frank Panitz
The American mink (Neovison vison) is a semiaquatic species of mustelid native to North America. It's an important animal for the fur industry. Many efforts have been made to locate genes influencing fur quality and color, but this search has been impeded by the lack of a reference genome. Here we present the first draft genome of mink. In our study, two mink individuals were sequenced by Illumina sequencing with 797 Gb sequence generated. Assembly yielded 7,175 scaffolds with an N50 of 6.3 Mb and length of 2...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29109276/contemporary-h3n2-influenza-viruses-have-a-glycosylation-site-that-alters-binding-of-antibodies-elicited-by-egg-adapted-vaccine-strains
#13
Seth J Zost, Kaela Parkhouse, Megan E Gumina, Kangchon Kim, Sebastian Diaz Perez, Patrick C Wilson, John J Treanor, Andrea J Sant, Sarah Cobey, Scott E Hensley
H3N2 viruses continuously acquire mutations in the hemagglutinin (HA) glycoprotein that abrogate binding of human antibodies. During the 2014-2015 influenza season, clade 3C.2a H3N2 viruses possessing a new predicted glycosylation site in antigenic site B of HA emerged, and these viruses remain prevalent today. The 2016-2017 seasonal influenza vaccine was updated to include a clade 3C.2a H3N2 strain; however, the egg-adapted version of this viral strain lacks the new putative glycosylation site. Here, we biochemically demonstrate that the HA antigenic site B of circulating clade 3C...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29100705/broad-cross-protective-anti-hemagglutination-responses-elicited-by-influenza-microconsensus-dna-vaccine
#14
Jian Yan, Matthew P Morrow, Jaemi S Chu, Trina Racine, Charles C Reed, Amir S Khan, Kate E Broderick, J Joseph Kim, Gary P Kobinger, Niranjan Y Sardesai, David B Weiner
Despite the routine development and distribution of seasonal influenza vaccines, influenza remains an important pathogen contributing to significant human morbidity as well as mortality each year. The seasonal variability of influenza creates a significant issue for vaccine development of seasonal strains that can afford protection from infection or disease based on serotype matching. It is appreciated that the globular head of the HA antigen contained in the vaccines generates antibodies that result in HAI activity that are a major correlates of the protection against a particular strain...
October 31, 2017: Vaccine
https://www.readbyqxmd.com/read/29100346/inhibition-of-hiv-1-infection-in-humanized-mice-and-metabolic-stability-of-protein-phosphatase-1-targeting-small-molecule-1e7-03
#15
Xionghao Lin, Namita Kumari, Catherine DeMarino, Yasemin Saygideğer Kont, Tatiana Ammosova, Amol Kulkarni, Marina Jerebtsova, Guelaguetza Vazquez-Meves, Andrey Ivanov, Kovalskyy Dmytro, Aykut Üren, Fatah Kashanchi, Sergei Nekhai
We recently identified the protein phosphatase-1 - targeting compound, 1E7-03 which inhibited HIV-1 in vitro. Here, we investigated the effect of 1E7-03 on HIV-1 infection in vivo by analyzing its metabolic stability and antiviral activity of 1E7-03 and its metabolites in HIV-1 infected NSG-humanized mice. 1E7-03 was degraded in serum and formed two major degradation products, DP1 and DP3, which bound protein phosphatase-1 in vitro. However, their anti-viral activities were significantly reduced due to inefficient cell permeability...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29080770/atypical-fatal-sarcocystosis-associated-with-sarcocystis-neurona-in-a-white-nosed-coati-nasua-narica-molaris
#16
Jitender P Dubey, John G Trupkiewicz, Shiv K Verma, Joseph D Mowery, Gloria Adedoyin, Tim Georoff, Michael E Grigg
The protozoan parasite Sarcocystis neurona is an important cause of disease in horses (equine protozoal myeloencephalitis, EPM) and marine mammals. Isolated reports of clinical EPM-like disease have been documented in a zebra, raccoon, domestic cat, domestic dog, ferret, skunk, mink, lynx, red panda and fisher. The predominant disease is encephalomyelitis associated with schizonts in neural tissues. Here, we report highly disseminated sarcocystosis, in many tissues of a captive White-nosed coati (Nasua narica molaris)...
November 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/29079697/infection-of-ferrets-with-influenza-virus-elicits-a-light-chain-biased-antibody-response-against-hemagglutinin
#17
Greg A Kirchenbaum, James D Allen, Thomas S Layman, Giuseppe A Sautto, Ted M Ross
The domestic ferret (Mustela putorius furo) is a commonly used animal model for the study of influenza virus infection and vaccination. Recently, our group has developed murine mAbs with specificity for the κ (Igκ) and λ (Igλ) L chains of ferret Ig. These mAbs were used to quantify the abundance of Igκ and Igλ in serum and to evaluate L chain usage of the Ab response against the hemagglutinin (HA) protein elicited by influenza infection. After influenza A infection of immunologically naive ferrets with various H1N1 or H3N2 strains, the acute Ab response against HA exhibited an inherent bias toward λ L chain usage...
October 27, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29077751/use-of-ferrets-for-electrophysiologic-monitoring-of-ion-transport
#18
Niroop Kaza, S Vamsee Raju, Joan M Cadillac, John A Trombley, Lawrence Rasmussen, Liping Tang, Erik Dohm, Kevin S Harrod, Steven M Rowe
Limited success achieved in translating basic science discoveries into clinical applications for chronic airway diseases is attributed to differences in respiratory anatomy and physiology, poor approximation of pathologic processes, and lack of correlative clinical endpoints between humans and laboratory animal models. Here, we discuss advantages of using ferrets (Mustela putorus furo) as a model for improved understanding of human airway physiology and demonstrate assays for quantifying airway epithelial ion transport in vivo and ex vivo, and establish air-liquid interface cultures of ferret airway epithelial cells as a complementary in vitro model for mechanistic studies...
2017: PloS One
https://www.readbyqxmd.com/read/29077710/the-influence-of-astrocytes-on-the-width-of-orientation-hypercolumns-in-visual-cortex-a-computational-perspective
#19
Ryan T Philips, Mriganka Sur, V Srinivasa Chakravarthy
Orientation preference maps (OPMs) are present in carnivores (such as cats and ferrets) and primates but are absent in rodents. In this study we investigate the possible link between astrocyte arbors and presence of OPMs. We simulate the development of orientation maps with varying hypercolumn widths using a variant of the Laterally Interconnected Synergetically Self-Organizing Map (LISSOM) model, the Gain Control Adaptive Laterally connected (GCAL) model, with an additional layer simulating astrocytic activation...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29064728/preparation-and-evaluation-of-a-novel-live-attenuated-influenza-h1n1-vaccine-strain-produced-by-a-modified-classical-reassortment-method
#20
Yunfeng Long, Lei Ma, Ze Liu, Shaohui Song, Xingliang Geng, Fan Yang, Qi Guo, Zhuofan Li, Weidong Li, Guoyang Liao
Live attenuated influenza vaccine (LAIV)-based Vero cells could provide a better choice to control and prevent influenza virus infections. This study used the human influenza virus A/Yunnan/1/2005Vca(H3N2) (YN/05Vca) as a donor strain. YN/05Vca has a double phenotype of cold adaption (ca) and Vero cell adaption (va). The parental virus strain used was the wild-type A/Solomon Islands/3/2006 (H1N1) (SI/06wt). The study employed the modified classical reassortment method to generate a new virus strain. After co-infection of Vero cells, some different sub-types of the reassorted viruses were generated randomly...
October 24, 2017: Human Vaccines & Immunotherapeutics
keyword
keyword
50278
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"